1. Трухан Д.И., Тарасова Л.В. Рациональная фармакотерапия и лекарственная безопасность в кардиологии. Справ. поликлин. врача. 2013; 5: 21–6. / Trukhan D.I., Tarasova L.V. Ratsional'naia farmakoterapiia i lekarstvennaia bezopasnost' v kardiologii. Sprav. poliklin. vracha. 2013; 5: 21–6. [in Russian]
2. Трухан Д.И., Тарасова Л.В. Оптимизация лекарственной терапии ишемической болезни сердца и артериальной гипертензии: выбор ингибитора ангиотензинпревращающего фермента. Системные гипертензии. 2014; 1: 73–7. / Trukhan D.I., Tarasova L.V. Optimization of drug therapy of coronary heart disease and arterial hypertension: choice angiotensin-converting enzyme inhibitors. System Hypertension. 2014; 1: 73–7. [in Russian]
3. Демографический ежегодник России. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm / Demograficheskii ezhegodnik Rossii. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm [in Russian]
4. Трухан Л.Ю., Трухан Д.И. Стоматологические проблемы гастроэнтерологических пациентов. Dental Tribune Russia. 2015; 2: 12. / Trukhan L.Iu., Trukhan D.I. Stomatologicheskie problemy gastroenterologicheskikh patsientov. Dental Tribune Russia. 2015; 2: 12. [in Russian]
5. Клинические рекомендации (протоколы лечения) при диагнозе пародонтит. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/ / Klinicheskie rekomendatsii (protokoly lecheniia) pri diagnoze parodontit. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/ [in Russian]
6. Van Dyke TE, Starr JR. Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc 2013; 2 (6): e000657.
7. Carramolino-Cuéllar E, Tomás I, Jiménez-Soriano Y. Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome. Med Oral Patol Oral Cir Bucal 2014; 19 (3): 289–94.
8. Rettori E, De Laurentiis A, Dees WL et al. Host neuro-immuno-endocrine responses in periodontal disease. Curr Pharm Des 2014; 20 (29): 4749–59.
9. Gurav AN. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014; 11 (1): 1–10.
10. Hatipoglu H, Yaylak F, Gungor Y. A brief review on the periodontal health in metabolic syndrome patients. Diabetes Metab Syndr 2015. pii: S1871-4021(15)00020-X.
11. Watanabe K, Cho YD. Periodontal disease and metabolic syndrome: a qualitative critical review of their association. Arch Oral Biol 2014; 59 (8): 855–70.
12. Benguigui C, Bongard V, Ruidavets JB et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population. J Clin Periodontol 2010; 37 (7): 601–8.
13. Timonen P, Niskanen M, Suominen-Taipale L et al. Metabolic syndrome, periodontal infection, and dental caries. J Dent Res 2010; 89 (10): 1068–73.
14. Andriankaja OM, Sreenivasa S, Dunford R, DeNardin E. Association between metabolic syndrome and periodontal disease. Aust Dent J 2010; 55 (3): 252–9.
15. Patel SP, Kalra N, Pradeep AR et al. Association of metabolic syndrome and periodontal disease in an Indian population. J Int Acad Periodontol 2014; 16 (4): 98–102.
16. Pires JR, Dos Santos IP, de Camargo LF et al. Framingham cardiovascular risk in patients with obesity and periodontitis. J Indian Soc Periodontol 2014; 18 (1): 14–8.
17. Zeigler CC, Wondimu B, Marcus C, Modeer T. Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents. BMC Oral Health. 2015; 15 (1): 41.
18. Bascones-Martinez A, Munoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc) 2014. pii: S0025-7753(14)00571-5.
19. Трухан Д.И., Викторова И.А., Трухан Л.Ю. Изменение органов и тканей полости рта при заболеваниях внутренних органов. М.: Практическая медицина, 2012. / Trukhan D.I., Viktorova I.A., Trukhan L.Iu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. M.: Prakticheskaia meditsina, 2012. [in Russian]
20. Трухан Л.Ю. Клинико-лабораторная характеристика состояния полости рта и уровни резистентности зубов к кариесу у больных инсулинзависимым сахарным диабетом. Автореф. дис. … канд. мед. наук. Омск, 1994. / Trukhan L.Iu. Kliniko-laboratornaia kharakteristika sostoianiia polosti rta i urovni rezistentnosti zubov k kariesu u bol'nykh insulinzavisimym sakharnym diabetom. Avtoref. dis. … kand. med. nauk. Omsk, 1994. [in Russian]
21. Гришечкина И.А., Трухан Л.Ю., Трухан Д.И., Коншу Н.В. Оценка состояния гигиены полости рта и тканей пародонта у больных сахарным диабетом II типа. Dental Forum. 2014; 3: 45–50. / Grishechkina I.A., Trukhan L.Iu., Trukhan D.I., Konshu N.V. Otsenka sostoianiia gigieny polosti rta i tkanei parodonta u bol'nykh sakharnym diabetom II tipa. Dental Forum. 2014; 3: 45–50. [in Russian]
22. Трухан Л.Ю., Тарасова Л.В., Трухан Д.И. Изменения со стороны органов и тканей полости рта при эндокринных заболеваниях. Dental Tribune Russia. 2013; 6: 19. / Trukhan L.Iu., Tarasova L.V., Trukhan D.I. Izmeneniia so storony organov i tkanei polosti rta pri endokrinnykh zabolevaniiakh. Dental Tribune Russia. 2013; 6: 19. [in Russian]
23. Трухан Д.И., Тарасова Л.В., Трухан Л.Ю. Гастроэнтерологические нарушения у пациентов с сахарным диабетом. Справ. врача общей практики. 2013; 8: 51–9. / Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Gastroenterologicheskie narusheniia u patsientov s sakharnym diabetom. Sprav. vracha obshchei praktiki. 2013; 8: 51–9. [in Russian]
24. Трухан Д.И., Голошубина В.В., Трухан Л.Ю. Изменение верхних отделов желудочно-кишечного тракта у пациентов с сахарным диабетом: актуальные вопросы диагностики, лечения и контроля. Справ. поликлин. врача. 2014; 11: 40–3. / Trukhan D.I., Goloshubina V.V., Trukhan L.Iu. Izmenenie verkhnikh otdelov zheludochno-kishechnogo trakta u patsientov s sakharnym diabetom: aktual'nye voprosy diagnostiki, lecheniia i kontrolia. Sprav. poliklin. vracha. 2014; 11: 40–3. [in Russian]
25. Трухан Л.Ю., Трухан Д.И., Викторова И.А. Изменение органов и тканей полости рта при сахарном диабете и других эндокринных заболеваниях. Материалы ХХ международной научно-практической конференции «Актуальные вопросы стоматологии». Сб. статей. Омск: Изд-во ОмГМА, 2014; с. 199–202. / Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri sakharnom diabete i drugikh endokrinnykh zabolevaniiakh. Materialy KhKh mezhdunarodnoi nauchno-prakticheskoi konferentsii «Aktual'nye voprosy stomatologii». Sb. statei. Omsk: Izd-vo OmGMA, 2014; s. 199–202. [in Russian]
26. Franek E, Napora M, Blach A et al. Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis. J Clin Periodontol 2010; 37 (10): 875–80.
27. Franek E, Januszkiewicz-Caulier J, Blach A et al. Intima-media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol 2012; 70 (1): 7–13.
28. Boillot A, Bouchard P, Moss K et al. Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study. J Clin Periodontol 2015; 42 (4): 342–9.
29. Bascones-Martinez A, Gonzalez-Febles J, Sanz-Esporrin J. Diabetes and periodontal disease. Review of the literature. Am J Dent 2014; 27 (2): 63–7.
30. Zhang DH, Yuan QN, Zabala PM et al. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J 2014. doi: 10.1111/adj.12253.
31. Трухан Д.И., Викторова И.А. Внутренние болезни. Кардиология. Ревматология. М.: Медицинское информационное агентство, 2013. / Trukhan D.I., Viktorova I.A. Vnutrennie bolezni. Kardiologiia. Revmatologiia. M.: Meditsinskoe informatsionnoe agentstvo, 2013. [in Russian]
32. Salvi GE, Carollo-Bittel E, Lang NP. Effects the diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol 2008; 35 (8); Suppl.: 398–409.
33. Vieira CL, Cury PR, Miname MH et al. Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study. J Periodontol 2011; 82 (5): 683–8.
34. Golpasand Hagh L, Zakavi F, Hajizadeh F, Saleki M. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J 2014; 16 (12): e6577.
35. Sandi RM, Pol KG, Basavaraj P et al. Association of Serum Cholesterol, Triglyceride, High and Low Density Lipoprotein (HDL and LDL) Levels in Chronic Periodontitis Subjects with Risk for Cardiovascular Disease (CVD): A Cross Sectional Study. J Clin Diagn Res 2014; 8 (1): 214–6.
36. Vieira RW. Cardiovascular and periodontal diseases. Rev Bras Cir Cardiovasc 2014; 29 (1): VII–IX.
37. Leite AC, Carneiro VM, Guimaraes Mdo C. Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Rev Bras Cir Cardiovasc 2014; 29 (1): 69–77.
38. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
39. Tsioufis C, Kasiakogias A, Thomopoulos C, Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219 (1): 1–9.
40. Leong XF, Ng CY, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal 2014; 2014: 768237.
41. Vidal F, Figueredo CM, Cordovil I, Fischer RG. Higher prevalence of periodontitis in patients with refractory arterial hypertension: a case-control study. Oral Dis 2011; 17 (6): 560–3.
42. Zhang L, Li YF, Liang ZZ et al. The association between chronic periodontitis and hypertension in rural adult Uygur residents. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39 (12): 1140–4.
43. Iwashima Y, Kokubo Y, Ono T et al. Additive interaction of oral health disorders on risk of hypertension in a Japanese urban population: the Suita Study. Am J Hypertens 2014; 27 (5): 710–9.
44. Pralhad S, Thomas B, Kushtagi P. Periodontal disease and pregnancy hypertension: a clinical correlation. J Periodontol 2013; 84 (8): 1118–25.
45. Jockel-Schneider Y, Harks I, Haubitz I et al. Arterial stiffness and pulse wave reflection are increased in patients suffering from severe periodontitis. PLoS One 2014; 9 (8): e103449.
46. Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40 (7): 681–7.
47. Choi HM, Han K, Park YG, Park JB. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008–2010 Korea National Health and Nutrition Examination Survey. J Periodontol 2015: 1–19.
48. Kim HD, Sim SJ, Moon JY et al. Association between periodontitis and hemorrhagic stroke among Koreans: a case-control study. J Periodontol 2010; 81 (5): 658–65.
49. Lafon A, Tala S, Ahossi V et al. Association between periodontal disease and non-fatal ischemic stroke: a case-control study. Acta Odontol Scand 2014; 72 (8): 687–93.
50. Diouf M, Basse A, Ndiaye M et al. Stroke and periodontal disease in Senegal: case-control study. Public Health 2015. pii: S0033-3506(15)00100-6.
51. DeStefano F, Anda RF, Kahn HS et al. Dental disease and risk of coronary heart disease and mortality. BMJ 1993; 306: 688–91.
52. Wu T, Trevisan M, Genco RJ et al. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow‐up study. Arch Intern Med 2000; 160: 2749–55.
53. Beck JD, Elter JR, Heiss G et al. Relationship of periodontal disease to carotid artery intima‐media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol 2001; 21: 1816–22.
54. Meurman JH, Sanz M, Janket S. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15 (6): 403–13.
55. Dietrich T, Jimenez M, Krall Kaye EA et al. Age‐dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 2008; 117: 1668–74.
56. Jimenez M, Krall EA, Garcia RI et al. Periodontitis and incidence of cerebrovascular disease in men. Ann Neurol 2009; 66: 505–12.
57. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
58. Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol 2013; 84 (4 Suppl.): 51–69.
59. Kholy KE, Genco RJ, van Dyke TE. Oral infections and cardiovascular disease. Trends Endocrinol Metab 2015. pii: S1043-2760(15)00045-4.
60. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
61. Kodovazenitis G, Pitsavos C, Papadimitriou L et al. Periodontal disease is associated with higher levels of C-reactive protein in non-diabetic, non-smoking acute myocardial infarction patients. J Dent 2011; 39 (12): 849–54.
62. Heaton B, Applebaum KM, Rothman KJ et al. The influence of prevalent cohort bias in the association between periodontal disease progression and incident coronary heart disease. Ann Epidemiol 2014; 24 (10): 741–6.
63. Marfil-Alvarez R, Mesa F, Arrebola-Moreno A et al. Acute myocardial infarct size is related to periodontitis extent and severity. J Dent Res 2014; 93 (10): 993–8.
64. Orlandi M, Suvan J, Petrie A et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis. Atherosclerosis 2014; 236 (1): 39–46.
65. Yu H, Qi LT, Liu LS et al. Association of Carotid Intima-media Thickness and Atherosclerotic Plaque with Periodontal Status. J Dent Res 2014; 93 (8): 744–51.
66. Desvarieux M, Demmer RT, Jacobs DR et al. Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study. J Am Heart Assoc 2013; 2 (6): e000254.
67. Desvarieux M, Demmer RT, Rundek T et al. Periodontal microbiota and carotid intima‐media thickness: the oral infections and vascular disease epidemiology study (INVEST). Circulation 2005; 111: 576–82.
68. Yakob M, Soder B, Meurman JH et al. Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. J Periodontal Res 2011; 46 (6): 749–55.
69. Tapashetti RP, Guvva S, Patil SR et al. C-reactive Protein as Predict of Increased Carotid Intima Media Thickness in Patients with Chronic Periodontitis. J Int Oral Health 2014; 6 (4): 47–52.
70. Liu R, Moroi M, Yamamoto M et al. Presence and severity of Chlamydia pneumoniae and Cytomegalovirus infection on coronary plaques are associated with acute coronary syndromes. Int Heart J 2006; 47 (4): 511–9.
71. Offenbacher S, Beck JD, Moss K et al. Results from Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol 2009; 80 (2): 190–201.
72. Oliveira FJ, Vieira RW, Coelho OR et al. Inflamacao sistemica causada pela periodontite cronica em pacientes vitimas de ataque cardiaco isquemico agudo. Rev Bras Cir Cardiovasc 2010; 25 (1): 51–8.
73. Leishman SJ, Do HL, Ford PJ. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol 2010; 2. doi: 10.3402/jom.v2i0.5781.
74. Soares GM, Teles F, Starr JR et al. Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model. Antimicrob Agents Chemother 2015; 59 (5): 2791–8.
75. Socranski S, Haffajee AD. Periodontal microbial ecology. Peridontol 2000. 2005; 38: 135–87.
76. Olsen I. From the acta prize lecture 2014: the periodontal-systemic connection seen from a microbiological standpoint. Acta Odontol Scand 2015: 1–6.
77. Pussinen PJ, Nyyssonen K, Alfthan G et al. Serum antibody levels to actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005; 25: 833–8.
78. Beck JD, Eke P, Lin D et al. Associations between IgG antibody to oral organisms and carotid intima‐medial thickness in community‐dwelling adults. Atherosclerosis 2005; 183: 342–8.
79. Beck JD, Eke P, Heiss G et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation 2005; 112: 19–24.
80. Pussinen PJ, Alfthan G, Jousilahti P et al. Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis 2007; 193: 222–8.
81. Pussinen PJ, Tuomisto K, Jousilahti P et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 2007; 27: 1433–9.
82. Serra e Silva Filho W, Casarin RC, Nicolela EL. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One 2014; 9 (10): e109761.
83. Kozarov E, Dorn B, Shelburne C et al. Human atherosclerotic plaque contains viable invasive Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Arterioscler Thromb Vasc Biol 2005; 25: 17–8.
84. Kozarov Е. Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol 2012; 8 (1): 123–38.
85. Humphrey LL, Fu R, Buckley DI et al. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med. 2008;23(12):2079–2086.
86. Gibson FC, Hong C, Chou HH et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E‐deficient mice. Circulation 2004; 109: 2801–6.
87. Reyes L, Herrera D, Kozarov E et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Periodontol 2013; 84: 30–50.
88. Jain A, Batista EL, Serhan C et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun 2003; 71: 6012–8.
89. Page RC. The pathobiology of periodontal disease may affect systemic diseases: inversion of a paradigm. Ann Periodontol 1998; 3 (1): 108–20.
90. Loos BG, Craandijk J, Hoek FJ et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71 (10): 1528–34.
91. Badran Z, Struillou X, Verner C et al. Periodontitis as a risk factor for systemic disease: Are microparticles the missing link? Med Hypotheses 2015. pii: S0306-9877(15)00090-0.
92. Kalburgi V, Sravya L, Warad S et al. Role of systemic markers in periodontal diseases: a possible inflammatory burden and risk factor for cardiovascular diseases? Ann Med Health Sci Res 2014; 4 (3): 388–92.
93. Sharma A, Astekar M, Metgud R et al. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotech Histochem 2014; 89 (8): 577–82.
94. Ramirez JH, Parra B, Gutierrez S et al. Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study. Aust Dent J 2014; 59 (1): 29–36.
95. Lira-Junior R, Figueredo CM, Bouskela E, Fischer RG. Severe chronic periodontitis is associated with endothelial and microvascular dysfunctions: a pilot study. J Periodontol 2014; 85 (12): 1648–57.
96. Cotti E, Zedda A, Deidda M et al. Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women. J Endod 2015; 41 (5): 594–600.
97. Saffi MA, Furtado MV, Polanczyk CA et al. Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article. World J Cardiol 2015; 7 (1): 26–30.
98. Kimura K, Takase B. Significant association between periodontitis and cardiovascular risk. Circ J 2014; 78 (4): 837–8.
99. Reichert S, Schlitt A, Beschow V et al. Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease. J Periodontal Res 2015; 50 (2): 180–8.
100. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
101. Lopez NJ, Quintero A, Casanova PA et al. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial. J Periodontol 2012; 83 (3): 267–78.
102. Cullinan MP, Palmer JE, Faddy MJ et al. The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): a Randomised Controlled Trial. J Periodontol 2015: 1–14.
103. Hasturk H, Abdallah R, Kantarci A et al. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol 2015; 35 (5): 1123–33.
104. Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Dis 2000; 13 (3): 227–32.
105. Kinane DF, Lowe GD. How periodontal disease may contribute to cardiovascular disease. Periodontol 2000; 23: 121–6.
106. Трухан Л.Ю., Трухан Д.И., Викторова И.А. Изменение органов и тканей полости рта при заболеваниях внутренних органов. Справ. поликлин. врача. 2011; 7: 8–14. / Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Sprav. poliklin. vracha. 2011; 7: 8–14. [in Russian]
107. Трухан Д.И., Тарасова Л.В., Трухан Л.Ю. Изменения органов и тканей полости рта при заболеваниях сердечно-сосудистой системы и соединительной ткани, и их лекарственной терапии. Consilium Medicum. 2014; 1: 79–82. / Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Izmeneniia organov i tkanei polosti rta pri zabolevaniiakh serdechno-sosudistoi sistemy i soedinitel'noi tkani, i ikh lekarstvennoi terapii. Consilium Medicum. 2014; 1: 79–82. [in Russian]
108. Аронов Д.М. Плейотропные эффекты статинов. Кардиология. 2008; 8: 60–8. / Aronov D.M. Pleiotropnye effekty statinov. Kardiologiia. 2008; 8: 60–8. [in Russian]
109. Ray KK, Cannon CP. The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes. J Am Coll Cardiol 2005; 46: 1425–33.
110. Estanislau IM, Terceiro IR, Lisboa MR et al. Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review. Br J Clin Pharmacol 2014. doi: 10.1111/bcp.12564.
111. Subramanian S, Emami H, Vucic E. et al. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. J Am Coll Cardiol 2013; 62 (25): 2382–91.
________________________________________________
1. Trukhan D.I., Tarasova L.V. Ratsional'naia farmakoterapiia i lekarstvennaia bezopasnost' v kardiologii. Sprav. poliklin. vracha. 2013; 5: 21–6. [in Russian]
2. Trukhan D.I., Tarasova L.V. Optimization of drug therapy of coronary heart disease and arterial hypertension: choice angiotensin-converting enzyme inhibitors. System Hypertension. 2014; 1: 73–7. [in Russian]
3. Demograficheskii ezhegodnik Rossii. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm [in Russian]
4. Trukhan L.Iu., Trukhan D.I. Stomatologicheskie problemy gastroenterologicheskikh patsientov. Dental Tribune Russia. 2015; 2: 12. [in Russian]
5. Klinicheskie rekomendatsii (protokoly lecheniia) pri diagnoze parodontit. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/ [in Russian]
6. Van Dyke TE, Starr JR. Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc 2013; 2 (6): e000657.
7. Carramolino-Cuéllar E, Tomás I, Jiménez-Soriano Y. Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome. Med Oral Patol Oral Cir Bucal 2014; 19 (3): 289–94.
8. Rettori E, De Laurentiis A, Dees WL et al. Host neuro-immuno-endocrine responses in periodontal disease. Curr Pharm Des 2014; 20 (29): 4749–59.
9. Gurav AN. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014; 11 (1): 1–10.
10. Hatipoglu H, Yaylak F, Gungor Y. A brief review on the periodontal health in metabolic syndrome patients. Diabetes Metab Syndr 2015. pii: S1871-4021(15)00020-X.
11. Watanabe K, Cho YD. Periodontal disease and metabolic syndrome: a qualitative critical review of their association. Arch Oral Biol 2014; 59 (8): 855–70.
12. Benguigui C, Bongard V, Ruidavets JB et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population. J Clin Periodontol 2010; 37 (7): 601–8.
13. Timonen P, Niskanen M, Suominen-Taipale L et al. Metabolic syndrome, periodontal infection, and dental caries. J Dent Res 2010; 89 (10): 1068–73.
14. Andriankaja OM, Sreenivasa S, Dunford R, DeNardin E. Association between metabolic syndrome and periodontal disease. Aust Dent J 2010; 55 (3): 252–9.
15. Patel SP, Kalra N, Pradeep AR et al. Association of metabolic syndrome and periodontal disease in an Indian population. J Int Acad Periodontol 2014; 16 (4): 98–102.
16. Pires JR, Dos Santos IP, de Camargo LF et al. Framingham cardiovascular risk in patients with obesity and periodontitis. J Indian Soc Periodontol 2014; 18 (1): 14–8.
17. Zeigler CC, Wondimu B, Marcus C, Modeer T. Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents. BMC Oral Health. 2015; 15 (1): 41.
18. Bascones-Martinez A, Munoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc) 2014. pii: S0025-7753(14)00571-5.
19. Trukhan D.I., Viktorova I.A., Trukhan L.Iu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. M.: Prakticheskaia meditsina, 2012. [in Russian]
20. Trukhan L.Iu. Kliniko-laboratornaia kharakteristika sostoianiia polosti rta i urovni rezistentnosti zubov k kariesu u bol'nykh insulinzavisimym sakharnym diabetom. Avtoref. dis. … kand. med. nauk. Omsk, 1994. [in Russian]
21. Grishechkina I.A., Trukhan L.Iu., Trukhan D.I., Konshu N.V. Otsenka sostoianiia gigieny polosti rta i tkanei parodonta u bol'nykh sakharnym diabetom II tipa. Dental Forum. 2014; 3: 45–50. [in Russian]
22. Trukhan L.Iu., Tarasova L.V., Trukhan D.I. Izmeneniia so storony organov i tkanei polosti rta pri endokrinnykh zabolevaniiakh. Dental Tribune Russia. 2013; 6: 19. [in Russian]
23. Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Gastroenterologicheskie narusheniia u patsientov s sakharnym diabetom. Sprav. vracha obshchei praktiki. 2013; 8: 51–9. [in Russian]
24. Trukhan D.I., Goloshubina V.V., Trukhan L.Iu. Izmenenie verkhnikh otdelov zheludochno-kishechnogo trakta u patsientov s sakharnym diabetom: aktual'nye voprosy diagnostiki, lecheniia i kontrolia. Sprav. poliklin. vracha. 2014; 11: 40–3. [in Russian]
25. Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri sakharnom diabete i drugikh endokrinnykh zabolevaniiakh. Materialy KhKh mezhdunarodnoi nauchno-prakticheskoi konferentsii «Aktual'nye voprosy stomatologii». Sb. statei. Omsk: Izd-vo OmGMA, 2014; s. 199–202. [in Russian]
26. Franek E, Napora M, Blach A et al. Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis. J Clin Periodontol 2010; 37 (10): 875–80.
27. Franek E, Januszkiewicz-Caulier J, Blach A et al. Intima-media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol 2012; 70 (1): 7–13.
28. Boillot A, Bouchard P, Moss K et al. Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study. J Clin Periodontol 2015; 42 (4): 342–9.
29. Bascones-Martinez A, Gonzalez-Febles J, Sanz-Esporrin J. Diabetes and periodontal disease. Review of the literature. Am J Dent 2014; 27 (2): 63–7.
30. Zhang DH, Yuan QN, Zabala PM et al. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J 2014. doi: 10.1111/adj.12253.
31. Trukhan D.I., Viktorova I.A. Vnutrennie bolezni. Kardiologiia. Revmatologiia. M.: Meditsinskoe informatsionnoe agentstvo, 2013. [in Russian]
32. Salvi GE, Carollo-Bittel E, Lang NP. Effects the diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol 2008; 35 (8); Suppl.: 398–409.
33. Vieira CL, Cury PR, Miname MH et al. Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study. J Periodontol 2011; 82 (5): 683–8.
34. Golpasand Hagh L, Zakavi F, Hajizadeh F, Saleki M. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J 2014; 16 (12): e6577.
35. Sandi RM, Pol KG, Basavaraj P et al. Association of Serum Cholesterol, Triglyceride, High and Low Density Lipoprotein (HDL and LDL) Levels in Chronic Periodontitis Subjects with Risk for Cardiovascular Disease (CVD): A Cross Sectional Study. J Clin Diagn Res 2014; 8 (1): 214–6.
36. Vieira RW. Cardiovascular and periodontal diseases. Rev Bras Cir Cardiovasc 2014; 29 (1): VII–IX.
37. Leite AC, Carneiro VM, Guimaraes Mdo C. Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Rev Bras Cir Cardiovasc 2014; 29 (1): 69–77.
38. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
39. Tsioufis C, Kasiakogias A, Thomopoulos C, Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219 (1): 1–9.
40. Leong XF, Ng CY, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal 2014; 2014: 768237.
41. Vidal F, Figueredo CM, Cordovil I, Fischer RG. Higher prevalence of periodontitis in patients with refractory arterial hypertension: a case-control study. Oral Dis 2011; 17 (6): 560–3.
42. Zhang L, Li YF, Liang ZZ et al. The association between chronic periodontitis and hypertension in rural adult Uygur residents. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39 (12): 1140–4.
43. Iwashima Y, Kokubo Y, Ono T et al. Additive interaction of oral health disorders on risk of hypertension in a Japanese urban population: the Suita Study. Am J Hypertens 2014; 27 (5): 710–9.
44. Pralhad S, Thomas B, Kushtagi P. Periodontal disease and pregnancy hypertension: a clinical correlation. J Periodontol 2013; 84 (8): 1118–25.
45. Jockel-Schneider Y, Harks I, Haubitz I et al. Arterial stiffness and pulse wave reflection are increased in patients suffering from severe periodontitis. PLoS One 2014; 9 (8): e103449.
46. Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40 (7): 681–7.
47. Choi HM, Han K, Park YG, Park JB. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008–2010 Korea National Health and Nutrition Examination Survey. J Periodontol 2015: 1–19.
48. Kim HD, Sim SJ, Moon JY et al. Association between periodontitis and hemorrhagic stroke among Koreans: a case-control study. J Periodontol 2010; 81 (5): 658–65.
49. Lafon A, Tala S, Ahossi V et al. Association between periodontal disease and non-fatal ischemic stroke: a case-control study. Acta Odontol Scand 2014; 72 (8): 687–93.
50. Diouf M, Basse A, Ndiaye M et al. Stroke and periodontal disease in Senegal: case-control study. Public Health 2015. pii: S0033-3506(15)00100-6.
51. DeStefano F, Anda RF, Kahn HS et al. Dental disease and risk of coronary heart disease and mortality. BMJ 1993; 306: 688–91.
52. Wu T, Trevisan M, Genco RJ et al. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow‐up study. Arch Intern Med 2000; 160: 2749–55.
53. Beck JD, Elter JR, Heiss G et al. Relationship of periodontal disease to carotid artery intima‐media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol 2001; 21: 1816–22.
54. Meurman JH, Sanz M, Janket S. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15 (6): 403–13.
55. Dietrich T, Jimenez M, Krall Kaye EA et al. Age‐dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 2008; 117: 1668–74.
56. Jimenez M, Krall EA, Garcia RI et al. Periodontitis and incidence of cerebrovascular disease in men. Ann Neurol 2009; 66: 505–12.
57. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
58. Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol 2013; 84 (4 Suppl.): 51–69.
59. Kholy KE, Genco RJ, van Dyke TE. Oral infections and cardiovascular disease. Trends Endocrinol Metab 2015. pii: S1043-2760(15)00045-4.
60. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
61. Kodovazenitis G, Pitsavos C, Papadimitriou L et al. Periodontal disease is associated with higher levels of C-reactive protein in non-diabetic, non-smoking acute myocardial infarction patients. J Dent 2011; 39 (12): 849–54.
62. Heaton B, Applebaum KM, Rothman KJ et al. The influence of prevalent cohort bias in the association between periodontal disease progression and incident coronary heart disease. Ann Epidemiol 2014; 24 (10): 741–6.
63. Marfil-Alvarez R, Mesa F, Arrebola-Moreno A et al. Acute myocardial infarct size is related to periodontitis extent and severity. J Dent Res 2014; 93 (10): 993–8.
64. Orlandi M, Suvan J, Petrie A et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis. Atherosclerosis 2014; 236 (1): 39–46.
65. Yu H, Qi LT, Liu LS et al. Association of Carotid Intima-media Thickness and Atherosclerotic Plaque with Periodontal Status. J Dent Res 2014; 93 (8): 744–51.
66. Desvarieux M, Demmer RT, Jacobs DR et al. Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study. J Am Heart Assoc 2013; 2 (6): e000254.
67. Desvarieux M, Demmer RT, Rundek T et al. Periodontal microbiota and carotid intima‐media thickness: the oral infections and vascular disease epidemiology study (INVEST). Circulation 2005; 111: 576–82.
68. Yakob M, Soder B, Meurman JH et al. Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. J Periodontal Res 2011; 46 (6): 749–55.
69. Tapashetti RP, Guvva S, Patil SR et al. C-reactive Protein as Predict of Increased Carotid Intima Media Thickness in Patients with Chronic Periodontitis. J Int Oral Health 2014; 6 (4): 47–52.
70. Liu R, Moroi M, Yamamoto M et al. Presence and severity of Chlamydia pneumoniae and Cytomegalovirus infection on coronary plaques are associated with acute coronary syndromes. Int Heart J 2006; 47 (4): 511–9.
71. Offenbacher S, Beck JD, Moss K et al. Results from Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol 2009; 80 (2): 190–201.
72. Oliveira FJ, Vieira RW, Coelho OR et al. Inflamacao sistemica causada pela periodontite cronica em pacientes vitimas de ataque cardiaco isquemico agudo. Rev Bras Cir Cardiovasc 2010; 25 (1): 51–8.
73. Leishman SJ, Do HL, Ford PJ. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol 2010; 2. doi: 10.3402/jom.v2i0.5781.
74. Soares GM, Teles F, Starr JR et al. Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model. Antimicrob Agents Chemother 2015; 59 (5): 2791–8.
75. Socranski S, Haffajee AD. Periodontal microbial ecology. Peridontol 2000. 2005; 38: 135–87.
76. Olsen I. From the acta prize lecture 2014: the periodontal-systemic connection seen from a microbiological standpoint. Acta Odontol Scand 2015: 1–6.
77. Pussinen PJ, Nyyssonen K, Alfthan G et al. Serum antibody levels to actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005; 25: 833–8.
78. Beck JD, Eke P, Lin D et al. Associations between IgG antibody to oral organisms and carotid intima‐medial thickness in community‐dwelling adults. Atherosclerosis 2005; 183: 342–8.
79. Beck JD, Eke P, Heiss G et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation 2005; 112: 19–24.
80. Pussinen PJ, Alfthan G, Jousilahti P et al. Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis 2007; 193: 222–8.
81. Pussinen PJ, Tuomisto K, Jousilahti P et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 2007; 27: 1433–9.
82. Serra e Silva Filho W, Casarin RC, Nicolela EL. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One 2014; 9 (10): e109761.
83. Kozarov E, Dorn B, Shelburne C et al. Human atherosclerotic plaque contains viable invasive Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Arterioscler Thromb Vasc Biol 2005; 25: 17–8.
84. Kozarov Е. Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol 2012; 8 (1): 123–38.
85. Humphrey LL, Fu R, Buckley DI et al. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med. 2008;23(12):2079–2086.
86. Gibson FC, Hong C, Chou HH et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E‐deficient mice. Circulation 2004; 109: 2801–6.
87. Reyes L, Herrera D, Kozarov E et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Periodontol 2013; 84: 30–50.
88. Jain A, Batista EL, Serhan C et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun 2003; 71: 6012–8.
89. Page RC. The pathobiology of periodontal disease may affect systemic diseases: inversion of a paradigm. Ann Periodontol 1998; 3 (1): 108–20.
90. Loos BG, Craandijk J, Hoek FJ et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71 (10): 1528–34.
91. Badran Z, Struillou X, Verner C et al. Periodontitis as a risk factor for systemic disease: Are microparticles the missing link? Med Hypotheses 2015. pii: S0306-9877(15)00090-0.
92. Kalburgi V, Sravya L, Warad S et al. Role of systemic markers in periodontal diseases: a possible inflammatory burden and risk factor for cardiovascular diseases? Ann Med Health Sci Res 2014; 4 (3): 388–92.
93. Sharma A, Astekar M, Metgud R et al. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotech Histochem 2014; 89 (8): 577–82.
94. Ramirez JH, Parra B, Gutierrez S et al. Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study. Aust Dent J 2014; 59 (1): 29–36.
95. Lira-Junior R, Figueredo CM, Bouskela E, Fischer RG. Severe chronic periodontitis is associated with endothelial and microvascular dysfunctions: a pilot study. J Periodontol 2014; 85 (12): 1648–57.
96. Cotti E, Zedda A, Deidda M et al. Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women. J Endod 2015; 41 (5): 594–600.
97. Saffi MA, Furtado MV, Polanczyk CA et al. Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article. World J Cardiol 2015; 7 (1): 26–30.
98. Kimura K, Takase B. Significant association between periodontitis and cardiovascular risk. Circ J 2014; 78 (4): 837–8.
99. Reichert S, Schlitt A, Beschow V et al. Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease. J Periodontal Res 2015; 50 (2): 180–8.
100. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
101. Lopez NJ, Quintero A, Casanova PA et al. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial. J Periodontol 2012; 83 (3): 267–78.
102. Cullinan MP, Palmer JE, Faddy MJ et al. The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): a Randomised Controlled Trial. J Periodontol 2015: 1–14.
103. Hasturk H, Abdallah R, Kantarci A et al. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol 2015; 35 (5): 1123–33.
104. Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Dis 2000; 13 (3): 227–32.
105. Kinane DF, Lowe GD. How periodontal disease may contribute to cardiovascular disease. Periodontol 2000; 23: 121–6.
106. Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Sprav. poliklin. vracha. 2011; 7: 8–14. [in Russian]
107. Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Izmeneniia organov i tkanei polosti rta pri zabolevaniiakh serdechno-sosudistoi sistemy i soedinitel'noi tkani, i ikh lekarstvennoi terapii. Consilium Medicum. 2014; 1: 79–82. [in Russian]
108. Aronov D.M. Pleiotropnye effekty statinov. Kardiologiia. 2008; 8: 60–8. [in Russian]
109. Ray KK, Cannon CP. The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes. J Am Coll Cardiol 2005; 46: 1425–33.
110. Estanislau IM, Terceiro IR, Lisboa MR et al. Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review. Br J Clin Pharmacol 2014. doi: 10.1111/bcp.12564.
111. Subramanian S, Emami H, Vucic E. et al. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. J Am Coll Cardiol 2013; 62 (25): 2382–91.
Авторы
Д.И.Трухан*, Л.Ю.Трухан
ГБОУ ВПО Омская государственная медицинская академия Минздрава России. 644099, Россия, Омск, ул. Ленина, д. 12
*dmitry_trukhan@mail.ru
________________________________________________
D.I.Trukhan*, L.Yu.Trukhan
Omsk State Medical Academy of the Ministry of Health of the Russian Federation. 644099, Russian Federation, Omsk, ul. Lenina, d. 12
*dmitry_trukhan@mail.ru