Москва 125252, ул. Алабяна 13, корпус 1
+7 (495) 098-03-59
Заказать звонок
  • О портале
  • Контакты
  • ...
    Omnidoctor
    Библиотека
    • Издания для врачей
      • Consilium Medicum
      • Педиатрия.Consilium Medicum
      • Современная Онкология
      • Гинекология
      • Терапевтический архив
      • Газета «Участковый терапевт»
      • Газета «Женская консультация»
      • Газета «Участковый педиатр»
      • Справочник поликлинического врача
      • Cardioсоматика
      • Системные гипертензии
    • Издания для провизоров и фармацевтов
      • Газета «Первостольник»
      • Справочник провизора
    • Online-издания
      • Женская консультация
      • Участковый педиатр
      • Участковый терапевт
    Медиатека
    Мероприятия
    Спецпроекты
    • ИммуноГалактика (NEW!)
    • Гормональный оркестр
    • CardioSPACE
    • NeuroFusion (NEW!)
    • Современная Онкология
    • Урологика
    Пресс-центр
    Практикум
      Библиотека
      Медиатека
      Мероприятия
      Спецпроекты
      ИммуноГалактика (NEW!)
      Гормональный оркестр
      CardioSPACE
      NeuroFusion (NEW!)
      Современная Онкология
      Урологика
      Пресс-центр
      Практикум
      Omnidoctor
      Библиотека
      • Издания для врачей
        • Consilium Medicum
        • Педиатрия.Consilium Medicum
        • Современная Онкология
        • Гинекология
        • Терапевтический архив
        • Газета «Участковый терапевт»
        • Газета «Женская консультация»
        • Газета «Участковый педиатр»
        • Справочник поликлинического врача
        • Cardioсоматика
        • Системные гипертензии
      • Издания для провизоров и фармацевтов
        • Газета «Первостольник»
        • Справочник провизора
      • Online-издания
        • Женская консультация
        • Участковый педиатр
        • Участковый терапевт
      Медиатека
      Мероприятия
      Спецпроекты
      • ИммуноГалактика (NEW!)
      • Гормональный оркестр
      • CardioSPACE
      • NeuroFusion (NEW!)
      • Современная Онкология
      • Урологика
      Пресс-центр
      Практикум
        Omnidoctor
        • Библиотека
          • Назад
          • Библиотека
          • Издания для врачей
            • Назад
            • Издания для врачей
            • Consilium Medicum
            • Педиатрия.Consilium Medicum
            • Современная Онкология
            • Гинекология
            • Терапевтический архив
            • Газета «Участковый терапевт»
            • Газета «Женская консультация»
            • Газета «Участковый педиатр»
            • Справочник поликлинического врача
            • Cardioсоматика
            • Системные гипертензии
          • Издания для провизоров и фармацевтов
            • Назад
            • Издания для провизоров и фармацевтов
            • Газета «Первостольник»
            • Справочник провизора
          • Online-издания
            • Назад
            • Online-издания
            • Женская консультация
            • Участковый педиатр
            • Участковый терапевт
        • Медиатека
        • Мероприятия
        • Спецпроекты
          • Назад
          • Спецпроекты
          • ИммуноГалактика (NEW!)
          • Гормональный оркестр
          • CardioSPACE
          • NeuroFusion (NEW!)
          • Современная Онкология
          • Урологика
        • Пресс-центр
        • Практикум
        • Мой кабинет
        • +7 (495) 098-03-59
        Москва 125252, ул. Алабяна 13, корпус 1
        info@omnidoctor.ru
        • Вконтакте
        • Telegram
        • YouTube
        • Главная
        • Библиотека
        • Издания для врачей
        • Consilium Medicum
        • 2015
        • №5 Кардиология
        • Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке?

        Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке?

        Трухан Д.И., Трухан Л.Ю. Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке? Consilium Medicum. 2015; 17 (5): 73–79.

        ________________________________________________

        Trukhan D.I., Trukhan L.Yu. Periodontal and cardiovascular diseases: In parallel or in a bundle? Consilium Medicum. 2015; 17 (5): 73–79.

        Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке?

        Трухан Д.И., Трухан Л.Ю. Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке? Consilium Medicum. 2015; 17 (5): 73–79.

        ________________________________________________

        Trukhan D.I., Trukhan L.Yu. Periodontal and cardiovascular diseases: In parallel or in a bundle? Consilium Medicum. 2015; 17 (5): 73–79.

        • Читать PDF
          Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке?

        Материалы доступны только для специалистов сферы здравоохранения.
        Чтобы посмотреть материал полностью Авторизуйтесь или зарегистрируйтесь.

        • Аннотация
        • Полный текст
        • Список литературы
        • Авторы
        Аннотация
        Обзор посвящен многогранным взаимоотношениям между болезнями пародонта и сердечно-сосудистыми заболеваниями.

        Ключевые слова: болезни пародонта, сердечно-сосудистые заболевания, взаимоотношения.

        ________________________________________________

        The review deals with a multi-faceted relationship between periodontal disease and cardiovascular disease.

        Key words: periodontal disease, cardiovascular disease, relationship.

        Полный текст

        Материалы доступны только для специалистов сферы здравоохранения.
        Чтобы посмотреть материал полностью Авторизуйтесь или зарегистрируйтесь.

        Список литературы
        1. Трухан Д.И., Тарасова Л.В. Рациональная фармакотерапия и лекарственная безопасность в кардиологии. Справ. поликлин. врача. 2013; 5: 21–6. / Trukhan D.I., Tarasova L.V. Ratsional'naia farmakoterapiia i lekarstvennaia bezopasnost' v kardiologii. Sprav. poliklin. vracha. 2013; 5: 21–6. [in Russian]
        2. Трухан Д.И., Тарасова Л.В. Оптимизация лекарственной терапии ишемической болезни сердца и артериальной гипертензии: выбор ингибитора ангиотензинпревращающего фермента. Системные гипертензии. 2014; 1: 73–7. / Trukhan D.I., Tarasova L.V. Optimization of drug therapy of coronary heart disease and arterial hypertension: choice angiotensin-converting enzyme inhibitors. System Hypertension. 2014; 1: 73–7. [in Russian]
        3. Демографический ежегодник России. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm / Demograficheskii ezhegodnik Rossii. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm [in Russian]
        4. Трухан Л.Ю., Трухан Д.И. Стоматологические проблемы гастроэнтерологических пациентов. Dental Tribune Russia. 2015; 2: 12. / Trukhan L.Iu., Trukhan D.I. Stomatologicheskie problemy gastroenterologicheskikh patsientov. Dental Tribune Russia. 2015; 2: 12. [in Russian]
        5. Клинические рекомендации (протоколы лечения) при диагнозе пародонтит. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/ / Klinicheskie rekomendatsii (protokoly lecheniia) pri diagnoze parodontit. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/ [in Russian]
        6. Van Dyke TE, Starr JR. Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc 2013; 2 (6): e000657.
        7. Carramolino-Cuéllar E, Tomás I, Jiménez-Soriano Y. Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome. Med Oral Patol Oral Cir Bucal 2014; 19 (3): 289–94.
        8. Rettori E, De Laurentiis A, Dees WL et al. Host neuro-immuno-endocrine responses in periodontal disease. Curr Pharm Des 2014; 20 (29): 4749–59.
        9. Gurav AN. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014; 11 (1): 1–10.
        10. Hatipoglu H, Yaylak F, Gungor Y. A brief review on the periodontal health in metabolic syndrome patients. Diabetes Metab Syndr 2015. pii: S1871-4021(15)00020-X.
        11. Watanabe K, Cho YD. Periodontal disease and metabolic syndrome: a qualitative critical review of their association. Arch Oral Biol 2014; 59 (8): 855–70.
        12. Benguigui C, Bongard V, Ruidavets JB et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population. J Clin Periodontol 2010; 37 (7): 601–8.
        13. Timonen P, Niskanen M, Suominen-Taipale L et al. Metabolic syndrome, periodontal infection, and dental caries. J Dent Res 2010; 89 (10): 1068–73.
        14. Andriankaja OM, Sreenivasa S, Dunford R, DeNardin E. Association between metabolic syndrome and periodontal disease. Aust Dent J 2010; 55 (3): 252–9.
        15. Patel SP, Kalra N, Pradeep AR et al. Association of metabolic syndrome and periodontal disease in an Indian population. J Int Acad Periodontol 2014; 16 (4): 98–102.
        16. Pires JR, Dos Santos IP, de Camargo LF et al. Framingham cardiovascular risk in patients with obesity and periodontitis. J Indian Soc Periodontol 2014; 18 (1): 14–8.
        17. Zeigler CC, Wondimu B, Marcus C, Modeer T. Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents. BMC Oral Health. 2015; 15 (1): 41.
        18. Bascones-Martinez A, Munoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc) 2014. pii: S0025-7753(14)00571-5.
        19. Трухан Д.И., Викторова И.А., Трухан Л.Ю. Изменение органов и тканей полости рта при заболеваниях внутренних органов. М.: Практическая медицина, 2012. / Trukhan D.I., Viktorova I.A., Trukhan L.Iu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. M.: Prakticheskaia meditsina, 2012. [in Russian]
        20. Трухан Л.Ю. Клинико-лабораторная характеристика состояния полости рта и уровни резистентности зубов к кариесу у больных инсулинзависимым сахарным диабетом. Автореф. дис. … канд. мед. наук. Омск, 1994. / Trukhan L.Iu. Kliniko-laboratornaia kharakteristika sostoianiia polosti rta i urovni rezistentnosti zubov k kariesu u bol'nykh insulinzavisimym sakharnym diabetom. Avtoref. dis. … kand. med. nauk. Omsk, 1994. [in Russian]
        21. Гришечкина И.А., Трухан Л.Ю., Трухан Д.И., Коншу Н.В. Оценка состояния гигиены полости рта и тканей пародонта у больных сахарным диабетом II типа. Dental Forum. 2014; 3: 45–50. / Grishechkina I.A., Trukhan L.Iu., Trukhan D.I., Konshu N.V. Otsenka sostoianiia gigieny polosti rta i tkanei parodonta u bol'nykh sakharnym diabetom II tipa. Dental Forum. 2014; 3: 45–50. [in Russian]
        22. Трухан Л.Ю., Тарасова Л.В., Трухан Д.И. Изменения со стороны органов и тканей полости рта при эндокринных заболеваниях. Dental Tribune Russia. 2013; 6: 19. / Trukhan L.Iu., Tarasova L.V., Trukhan D.I. Izmeneniia so storony organov i tkanei polosti rta pri endokrinnykh zabolevaniiakh. Dental Tribune Russia. 2013; 6: 19. [in Russian]
        23. Трухан Д.И., Тарасова Л.В., Трухан Л.Ю. Гастроэнтерологические нарушения у пациентов с сахарным диабетом. Справ. врача общей практики. 2013; 8: 51–9. / Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Gastroenterologicheskie narusheniia u patsientov s sakharnym diabetom. Sprav. vracha obshchei praktiki. 2013; 8: 51–9. [in Russian]
        24. Трухан Д.И., Голошубина В.В., Трухан Л.Ю. Изменение верхних отделов желудочно-кишечного тракта у пациентов с сахарным диабетом: актуальные вопросы диагностики, лечения и контроля. Справ. поликлин. врача. 2014; 11: 40–3. / Trukhan D.I., Goloshubina V.V., Trukhan L.Iu. Izmenenie verkhnikh otdelov zheludochno-kishechnogo trakta u patsientov s sakharnym diabetom: aktual'nye voprosy diagnostiki, lecheniia i kontrolia. Sprav. poliklin. vracha. 2014; 11: 40–3. [in Russian]
        25. Трухан Л.Ю., Трухан Д.И., Викторова И.А. Изменение органов и тканей полости рта при сахарном диабете и других эндокринных заболеваниях. Материалы ХХ международной научно-практической конференции «Актуальные вопросы стоматологии». Сб. статей. Омск: Изд-во ОмГМА, 2014; с. 199–202. / Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri sakharnom diabete i drugikh endokrinnykh zabolevaniiakh. Materialy KhKh mezhdunarodnoi nauchno-prakticheskoi konferentsii «Aktual'nye voprosy stomatologii». Sb. statei. Omsk: Izd-vo OmGMA, 2014; s. 199–202. [in Russian]
        26. Franek E, Napora M, Blach A et al. Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis. J Clin Periodontol 2010; 37 (10): 875–80.
        27. Franek E, Januszkiewicz-Caulier J, Blach A et al. Intima-media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol 2012; 70 (1): 7–13.
        28. Boillot A, Bouchard P, Moss K et al. Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study. J Clin Periodontol 2015; 42 (4): 342–9.
        29. Bascones-Martinez A, Gonzalez-Febles J, Sanz-Esporrin J. Diabetes and periodontal disease. Review of the literature. Am J Dent 2014; 27 (2): 63–7.
        30. Zhang DH, Yuan QN, Zabala PM et al. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J 2014. doi: 10.1111/adj.12253.
        31. Трухан Д.И., Викторова И.А. Внутренние болезни. Кардиология. Ревматология. М.: Медицинское информационное агентство, 2013. / Trukhan D.I., Viktorova I.A. Vnutrennie bolezni. Kardiologiia. Revmatologiia. M.: Meditsinskoe informatsionnoe agentstvo, 2013. [in Russian]
        32. Salvi GE, Carollo-Bittel E, Lang NP. Effects the diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol 2008; 35 (8); Suppl.: 398–409.
        33. Vieira CL, Cury PR, Miname MH et al. Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study. J Periodontol 2011; 82 (5): 683–8.
        34. Golpasand Hagh L, Zakavi F, Hajizadeh F, Saleki M. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J 2014; 16 (12): e6577.
        35. Sandi RM, Pol KG, Basavaraj P et al. Association of Serum Cholesterol, Triglyceride, High and Low Density Lipoprotein (HDL and LDL) Levels in Chronic Periodontitis Subjects with Risk for Cardiovascular Disease (CVD): A Cross Sectional Study. J Clin Diagn Res 2014; 8 (1): 214–6.
        36. Vieira RW. Cardiovascular and periodontal diseases. Rev Bras Cir Cardiovasc 2014; 29 (1): VII–IX.
        37. Leite AC, Carneiro VM, Guimaraes Mdo C. Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Rev Bras Cir Cardiovasc 2014; 29 (1): 69–77.
        38. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
        39. Tsioufis C, Kasiakogias A, Thomopoulos C, Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219 (1): 1–9.
        40. Leong XF, Ng CY, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal 2014; 2014: 768237.
        41. Vidal F, Figueredo CM, Cordovil I, Fischer RG. Higher prevalence of periodontitis in patients with refractory arterial hypertension: a case-control study. Oral Dis 2011; 17 (6): 560–3.
        42. Zhang L, Li YF, Liang ZZ et al. The association between chronic periodontitis and hypertension in rural adult Uygur residents. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39 (12): 1140–4.
        43. Iwashima Y, Kokubo Y, Ono T et al. Additive interaction of oral health disorders on risk of hypertension in a Japanese urban population: the Suita Study. Am J Hypertens 2014; 27 (5): 710–9.
        44. Pralhad S, Thomas B, Kushtagi P. Periodontal disease and pregnancy hypertension: a clinical correlation. J Periodontol 2013; 84 (8): 1118–25.
        45. Jockel-Schneider Y, Harks I, Haubitz I et al. Arterial stiffness and pulse wave reflection are increased in patients suffering from severe periodontitis. PLoS One 2014; 9 (8): e103449.
        46. Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40 (7): 681–7.
        47. Choi HM, Han K, Park YG, Park JB. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008–2010 Korea National Health and Nutrition Examination Survey. J Periodontol 2015: 1–19.
        48. Kim HD, Sim SJ, Moon JY et al. Association between periodontitis and hemorrhagic stroke among Koreans: a case-control study. J Periodontol 2010; 81 (5): 658–65.
        49. Lafon A, Tala S, Ahossi V et al. Association between periodontal disease and non-fatal ischemic stroke: a case-control study. Acta Odontol Scand 2014; 72 (8): 687–93.
        50. Diouf M, Basse A, Ndiaye M et al. Stroke and periodontal disease in Senegal: case-control study. Public Health 2015. pii: S0033-3506(15)00100-6.
        51. DeStefano F, Anda RF, Kahn HS et al. Dental disease and risk of coronary heart disease and mortality. BMJ 1993; 306: 688–91.
        52. Wu T, Trevisan M, Genco RJ et al. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow‐up study. Arch Intern Med 2000; 160: 2749–55.
        53. Beck JD, Elter JR, Heiss G et al. Relationship of periodontal disease to carotid artery intima‐media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol 2001; 21: 1816–22.
        54. Meurman JH, Sanz M, Janket S. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15 (6): 403–13.
        55. Dietrich T, Jimenez M, Krall Kaye EA et al. Age‐dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 2008; 117: 1668–74.
        56. Jimenez M, Krall EA, Garcia RI et al. Periodontitis and incidence of cerebrovascular disease in men. Ann Neurol 2009; 66: 505–12.
        57. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
        58. Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol 2013; 84 (4 Suppl.): 51–69.
        59. Kholy KE, Genco RJ, van Dyke TE. Oral infections and cardiovascular disease. Trends Endocrinol Metab 2015. pii: S1043-2760(15)00045-4.
        60. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
        61. Kodovazenitis G, Pitsavos C, Papadimitriou L et al. Periodontal disease is associated with higher levels of C-reactive protein in non-diabetic, non-smoking acute myocardial infarction patients. J Dent 2011; 39 (12): 849–54.
        62. Heaton B, Applebaum KM, Rothman KJ et al. The influence of prevalent cohort bias in the association between periodontal disease progression and incident coronary heart disease. Ann Epidemiol 2014; 24 (10): 741–6.
        63. Marfil-Alvarez R, Mesa F, Arrebola-Moreno A et al. Acute myocardial infarct size is related to periodontitis extent and severity. J Dent Res 2014; 93 (10): 993–8.
        64. Orlandi M, Suvan J, Petrie A et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis. Atherosclerosis 2014; 236 (1): 39–46.
        65. Yu H, Qi LT, Liu LS et al. Association of Carotid Intima-media Thickness and Atherosclerotic Plaque with Periodontal Status. J Dent Res 2014; 93 (8): 744–51.
        66. Desvarieux M, Demmer RT, Jacobs DR et al. Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study. J Am Heart Assoc 2013; 2 (6): e000254.
        67. Desvarieux M, Demmer RT, Rundek T et al. Periodontal microbiota and carotid intima‐media thickness: the oral infections and vascular disease epidemiology study (INVEST). Circulation 2005; 111: 576–82.
        68. Yakob M, Soder B, Meurman JH et al. Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. J Periodontal Res 2011; 46 (6): 749–55.
        69. Tapashetti RP, Guvva S, Patil SR et al. C-reactive Protein as Predict of Increased Carotid Intima Media Thickness in Patients with Chronic Periodontitis. J Int Oral Health 2014; 6 (4): 47–52.
        70. Liu R, Moroi M, Yamamoto M et al. Presence and severity of Chlamydia pneumoniae and Cytomegalovirus infection on coronary plaques are associated with acute coronary syndromes. Int Heart J 2006; 47 (4): 511–9.
        71. Offenbacher S, Beck JD, Moss K et al. Results from Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol 2009; 80 (2): 190–201.
        72. Oliveira FJ, Vieira RW, Coelho OR et al. Inflamacao sistemica causada pela periodontite cronica em pacientes vitimas de ataque cardiaco isquemico agudo. Rev Bras Cir Cardiovasc 2010; 25 (1): 51–8.
        73. Leishman SJ, Do HL, Ford PJ. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol 2010; 2. doi: 10.3402/jom.v2i0.5781.
        74. Soares GM, Teles F, Starr JR et al. Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model. Antimicrob Agents Chemother 2015; 59 (5): 2791–8.
        75. Socranski S, Haffajee AD. Periodontal microbial ecology. Peridontol 2000. 2005; 38: 135–87.
        76. Olsen I. From the acta prize lecture 2014: the periodontal-systemic connection seen from a microbiological standpoint. Acta Odontol Scand 2015: 1–6.
        77. Pussinen PJ, Nyyssonen K, Alfthan G et al. Serum antibody levels to actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005; 25: 833–8.
        78. Beck JD, Eke P, Lin D et al. Associations between IgG antibody to oral organisms and carotid intima‐medial thickness in community‐dwelling adults. Atherosclerosis 2005; 183: 342–8.
        79. Beck JD, Eke P, Heiss G et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation 2005; 112: 19–24.
        80. Pussinen PJ, Alfthan G, Jousilahti P et al. Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis 2007; 193: 222–8.
        81. Pussinen PJ, Tuomisto K, Jousilahti P et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 2007; 27: 1433–9.
        82. Serra e Silva Filho W, Casarin RC, Nicolela EL. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One 2014; 9 (10): e109761.
        83. Kozarov E, Dorn B, Shelburne C et al. Human atherosclerotic plaque contains viable invasive Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Arterioscler Thromb Vasc Biol 2005; 25: 17–8.
        84. Kozarov Е. Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol 2012; 8 (1): 123–38.
        85. Humphrey LL, Fu R, Buckley DI et al. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med. 2008;23(12):2079–2086.
        86. Gibson FC, Hong C, Chou HH et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E‐deficient mice. Circulation 2004; 109: 2801–6.
        87. Reyes L, Herrera D, Kozarov E et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Periodontol 2013; 84: 30–50.
        88. Jain A, Batista EL, Serhan C et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun 2003; 71: 6012–8.
        89. Page RC. The pathobiology of periodontal disease may affect systemic diseases: inversion of a paradigm. Ann Periodontol 1998; 3 (1): 108–20.
        90. Loos BG, Craandijk J, Hoek FJ et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71 (10): 1528–34.
        91. Badran Z, Struillou X, Verner C et al. Periodontitis as a risk factor for systemic disease: Are microparticles the missing link? Med Hypotheses 2015. pii: S0306-9877(15)00090-0.
        92. Kalburgi V, Sravya L, Warad S et al. Role of systemic markers in periodontal diseases: a possible inflammatory burden and risk factor for cardiovascular diseases? Ann Med Health Sci Res 2014; 4 (3): 388–92.
        93. Sharma A, Astekar M, Metgud R et al. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotech Histochem 2014; 89 (8): 577–82.
        94. Ramirez JH, Parra B, Gutierrez S et al. Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study. Aust Dent J 2014; 59 (1): 29–36.
        95. Lira-Junior R, Figueredo CM, Bouskela E, Fischer RG. Severe chronic periodontitis is associated with endothelial and microvascular dysfunctions: a pilot study. J Periodontol 2014; 85 (12): 1648–57.
        96. Cotti E, Zedda A, Deidda M et al. Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women. J Endod 2015; 41 (5): 594–600.
        97. Saffi MA, Furtado MV, Polanczyk CA et al. Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article. World J Cardiol 2015; 7 (1): 26–30.
        98. Kimura K, Takase B. Significant association between periodontitis and cardiovascular risk. Circ J 2014; 78 (4): 837–8.
        99. Reichert S, Schlitt A, Beschow V et al. Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease. J Periodontal Res 2015; 50 (2): 180–8.
        100. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
        101. Lopez NJ, Quintero A, Casanova PA et al. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial. J Periodontol 2012; 83 (3): 267–78.
        102. Cullinan MP, Palmer JE, Faddy MJ et al. The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): a Randomised Controlled Trial. J Periodontol 2015: 1–14.
        103. Hasturk H, Abdallah R, Kantarci A et al. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol 2015; 35 (5): 1123–33.
        104. Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Dis 2000; 13 (3): 227–32.
        105. Kinane DF, Lowe GD. How periodontal disease may contribute to cardiovascular disease. Periodontol 2000; 23: 121–6.
        106. Трухан Л.Ю., Трухан Д.И., Викторова И.А. Изменение органов и тканей полости рта при заболеваниях внутренних органов. Справ. поликлин. врача. 2011; 7: 8–14. / Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Sprav. poliklin. vracha. 2011; 7: 8–14. [in Russian]
        107. Трухан Д.И., Тарасова Л.В., Трухан Л.Ю. Изменения органов и тканей полости рта при заболеваниях сердечно-сосудистой системы и соединительной ткани, и их лекарственной терапии. Consilium Medicum. 2014; 1: 79–82. / Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Izmeneniia organov i tkanei polosti rta pri zabolevaniiakh serdechno-sosudistoi sistemy i soedinitel'noi tkani, i ikh lekarstvennoi terapii. Consilium Medicum. 2014; 1: 79–82. [in Russian]
        108. Аронов Д.М. Плейотропные эффекты статинов. Кардиология. 2008; 8: 60–8. / Aronov D.M. Pleiotropnye effekty statinov. Kardiologiia. 2008; 8: 60–8. [in Russian]
        109. Ray KK, Cannon CP. The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes. J Am Coll Cardiol 2005; 46: 1425–33.
        110. Estanislau IM, Terceiro IR, Lisboa MR et al. Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review. Br J Clin Pharmacol 2014. doi: 10.1111/bcp.12564.
        111. Subramanian S, Emami H, Vucic E. et al. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. J Am Coll Cardiol 2013; 62 (25): 2382–91.

        ________________________________________________

        1. Trukhan D.I., Tarasova L.V. Ratsional'naia farmakoterapiia i lekarstvennaia bezopasnost' v kardiologii. Sprav. poliklin. vracha. 2013; 5: 21–6. [in Russian]
        2. Trukhan D.I., Tarasova L.V. Optimization of drug therapy of coronary heart disease and arterial hypertension: choice angiotensin-converting enzyme inhibitors. System Hypertension. 2014; 1: 73–7. [in Russian]
        3. Demograficheskii ezhegodnik Rossii. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm [in Russian]
        4. Trukhan L.Iu., Trukhan D.I. Stomatologicheskie problemy gastroenterologicheskikh patsientov. Dental Tribune Russia. 2015; 2: 12. [in Russian]
        5. Klinicheskie rekomendatsii (protokoly lecheniia) pri diagnoze parodontit. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/ [in Russian]
        6. Van Dyke TE, Starr JR. Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc 2013; 2 (6): e000657.
        7. Carramolino-Cuéllar E, Tomás I, Jiménez-Soriano Y. Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome. Med Oral Patol Oral Cir Bucal 2014; 19 (3): 289–94.
        8. Rettori E, De Laurentiis A, Dees WL et al. Host neuro-immuno-endocrine responses in periodontal disease. Curr Pharm Des 2014; 20 (29): 4749–59.
        9. Gurav AN. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014; 11 (1): 1–10.
        10. Hatipoglu H, Yaylak F, Gungor Y. A brief review on the periodontal health in metabolic syndrome patients. Diabetes Metab Syndr 2015. pii: S1871-4021(15)00020-X.
        11. Watanabe K, Cho YD. Periodontal disease and metabolic syndrome: a qualitative critical review of their association. Arch Oral Biol 2014; 59 (8): 855–70.
        12. Benguigui C, Bongard V, Ruidavets JB et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population. J Clin Periodontol 2010; 37 (7): 601–8.
        13. Timonen P, Niskanen M, Suominen-Taipale L et al. Metabolic syndrome, periodontal infection, and dental caries. J Dent Res 2010; 89 (10): 1068–73.
        14. Andriankaja OM, Sreenivasa S, Dunford R, DeNardin E. Association between metabolic syndrome and periodontal disease. Aust Dent J 2010; 55 (3): 252–9.
        15. Patel SP, Kalra N, Pradeep AR et al. Association of metabolic syndrome and periodontal disease in an Indian population. J Int Acad Periodontol 2014; 16 (4): 98–102.
        16. Pires JR, Dos Santos IP, de Camargo LF et al. Framingham cardiovascular risk in patients with obesity and periodontitis. J Indian Soc Periodontol 2014; 18 (1): 14–8.
        17. Zeigler CC, Wondimu B, Marcus C, Modeer T. Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents. BMC Oral Health. 2015; 15 (1): 41.
        18. Bascones-Martinez A, Munoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc) 2014. pii: S0025-7753(14)00571-5.
        19. Trukhan D.I., Viktorova I.A., Trukhan L.Iu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. M.: Prakticheskaia meditsina, 2012. [in Russian]
        20. Trukhan L.Iu. Kliniko-laboratornaia kharakteristika sostoianiia polosti rta i urovni rezistentnosti zubov k kariesu u bol'nykh insulinzavisimym sakharnym diabetom. Avtoref. dis. … kand. med. nauk. Omsk, 1994. [in Russian]
        21. Grishechkina I.A., Trukhan L.Iu., Trukhan D.I., Konshu N.V. Otsenka sostoianiia gigieny polosti rta i tkanei parodonta u bol'nykh sakharnym diabetom II tipa. Dental Forum. 2014; 3: 45–50. [in Russian]
        22. Trukhan L.Iu., Tarasova L.V., Trukhan D.I. Izmeneniia so storony organov i tkanei polosti rta pri endokrinnykh zabolevaniiakh. Dental Tribune Russia. 2013; 6: 19. [in Russian]
        23. Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Gastroenterologicheskie narusheniia u patsientov s sakharnym diabetom. Sprav. vracha obshchei praktiki. 2013; 8: 51–9. [in Russian]
        24. Trukhan D.I., Goloshubina V.V., Trukhan L.Iu. Izmenenie verkhnikh otdelov zheludochno-kishechnogo trakta u patsientov s sakharnym diabetom: aktual'nye voprosy diagnostiki, lecheniia i kontrolia. Sprav. poliklin. vracha. 2014; 11: 40–3. [in Russian]
        25. Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri sakharnom diabete i drugikh endokrinnykh zabolevaniiakh. Materialy KhKh mezhdunarodnoi nauchno-prakticheskoi konferentsii «Aktual'nye voprosy stomatologii». Sb. statei. Omsk: Izd-vo OmGMA, 2014; s. 199–202. [in Russian]
        26. Franek E, Napora M, Blach A et al. Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis. J Clin Periodontol 2010; 37 (10): 875–80.
        27. Franek E, Januszkiewicz-Caulier J, Blach A et al. Intima-media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol 2012; 70 (1): 7–13.
        28. Boillot A, Bouchard P, Moss K et al. Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study. J Clin Periodontol 2015; 42 (4): 342–9.
        29. Bascones-Martinez A, Gonzalez-Febles J, Sanz-Esporrin J. Diabetes and periodontal disease. Review of the literature. Am J Dent 2014; 27 (2): 63–7.
        30. Zhang DH, Yuan QN, Zabala PM et al. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J 2014. doi: 10.1111/adj.12253.
        31. Trukhan D.I., Viktorova I.A. Vnutrennie bolezni. Kardiologiia. Revmatologiia. M.: Meditsinskoe informatsionnoe agentstvo, 2013. [in Russian]
        32. Salvi GE, Carollo-Bittel E, Lang NP. Effects the diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol 2008; 35 (8); Suppl.: 398–409.
        33. Vieira CL, Cury PR, Miname MH et al. Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study. J Periodontol 2011; 82 (5): 683–8.
        34. Golpasand Hagh L, Zakavi F, Hajizadeh F, Saleki M. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J 2014; 16 (12): e6577.
        35. Sandi RM, Pol KG, Basavaraj P et al. Association of Serum Cholesterol, Triglyceride, High and Low Density Lipoprotein (HDL and LDL) Levels in Chronic Periodontitis Subjects with Risk for Cardiovascular Disease (CVD): A Cross Sectional Study. J Clin Diagn Res 2014; 8 (1): 214–6.
        36. Vieira RW. Cardiovascular and periodontal diseases. Rev Bras Cir Cardiovasc 2014; 29 (1): VII–IX.
        37. Leite AC, Carneiro VM, Guimaraes Mdo C. Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Rev Bras Cir Cardiovasc 2014; 29 (1): 69–77.
        38. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
        39. Tsioufis C, Kasiakogias A, Thomopoulos C, Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219 (1): 1–9.
        40. Leong XF, Ng CY, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal 2014; 2014: 768237.
        41. Vidal F, Figueredo CM, Cordovil I, Fischer RG. Higher prevalence of periodontitis in patients with refractory arterial hypertension: a case-control study. Oral Dis 2011; 17 (6): 560–3.
        42. Zhang L, Li YF, Liang ZZ et al. The association between chronic periodontitis and hypertension in rural adult Uygur residents. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39 (12): 1140–4.
        43. Iwashima Y, Kokubo Y, Ono T et al. Additive interaction of oral health disorders on risk of hypertension in a Japanese urban population: the Suita Study. Am J Hypertens 2014; 27 (5): 710–9.
        44. Pralhad S, Thomas B, Kushtagi P. Periodontal disease and pregnancy hypertension: a clinical correlation. J Periodontol 2013; 84 (8): 1118–25.
        45. Jockel-Schneider Y, Harks I, Haubitz I et al. Arterial stiffness and pulse wave reflection are increased in patients suffering from severe periodontitis. PLoS One 2014; 9 (8): e103449.
        46. Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40 (7): 681–7.
        47. Choi HM, Han K, Park YG, Park JB. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008–2010 Korea National Health and Nutrition Examination Survey. J Periodontol 2015: 1–19.
        48. Kim HD, Sim SJ, Moon JY et al. Association between periodontitis and hemorrhagic stroke among Koreans: a case-control study. J Periodontol 2010; 81 (5): 658–65.
        49. Lafon A, Tala S, Ahossi V et al. Association between periodontal disease and non-fatal ischemic stroke: a case-control study. Acta Odontol Scand 2014; 72 (8): 687–93.
        50. Diouf M, Basse A, Ndiaye M et al. Stroke and periodontal disease in Senegal: case-control study. Public Health 2015. pii: S0033-3506(15)00100-6.
        51. DeStefano F, Anda RF, Kahn HS et al. Dental disease and risk of coronary heart disease and mortality. BMJ 1993; 306: 688–91.
        52. Wu T, Trevisan M, Genco RJ et al. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow‐up study. Arch Intern Med 2000; 160: 2749–55.
        53. Beck JD, Elter JR, Heiss G et al. Relationship of periodontal disease to carotid artery intima‐media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol 2001; 21: 1816–22.
        54. Meurman JH, Sanz M, Janket S. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15 (6): 403–13.
        55. Dietrich T, Jimenez M, Krall Kaye EA et al. Age‐dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 2008; 117: 1668–74.
        56. Jimenez M, Krall EA, Garcia RI et al. Periodontitis and incidence of cerebrovascular disease in men. Ann Neurol 2009; 66: 505–12.
        57. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
        58. Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol 2013; 84 (4 Suppl.): 51–69.
        59. Kholy KE, Genco RJ, van Dyke TE. Oral infections and cardiovascular disease. Trends Endocrinol Metab 2015. pii: S1043-2760(15)00045-4.
        60. Friedewald VE, Kornman KS, Beck JD et al. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021–32.
        61. Kodovazenitis G, Pitsavos C, Papadimitriou L et al. Periodontal disease is associated with higher levels of C-reactive protein in non-diabetic, non-smoking acute myocardial infarction patients. J Dent 2011; 39 (12): 849–54.
        62. Heaton B, Applebaum KM, Rothman KJ et al. The influence of prevalent cohort bias in the association between periodontal disease progression and incident coronary heart disease. Ann Epidemiol 2014; 24 (10): 741–6.
        63. Marfil-Alvarez R, Mesa F, Arrebola-Moreno A et al. Acute myocardial infarct size is related to periodontitis extent and severity. J Dent Res 2014; 93 (10): 993–8.
        64. Orlandi M, Suvan J, Petrie A et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis. Atherosclerosis 2014; 236 (1): 39–46.
        65. Yu H, Qi LT, Liu LS et al. Association of Carotid Intima-media Thickness and Atherosclerotic Plaque with Periodontal Status. J Dent Res 2014; 93 (8): 744–51.
        66. Desvarieux M, Demmer RT, Jacobs DR et al. Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study. J Am Heart Assoc 2013; 2 (6): e000254.
        67. Desvarieux M, Demmer RT, Rundek T et al. Periodontal microbiota and carotid intima‐media thickness: the oral infections and vascular disease epidemiology study (INVEST). Circulation 2005; 111: 576–82.
        68. Yakob M, Soder B, Meurman JH et al. Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. J Periodontal Res 2011; 46 (6): 749–55.
        69. Tapashetti RP, Guvva S, Patil SR et al. C-reactive Protein as Predict of Increased Carotid Intima Media Thickness in Patients with Chronic Periodontitis. J Int Oral Health 2014; 6 (4): 47–52.
        70. Liu R, Moroi M, Yamamoto M et al. Presence and severity of Chlamydia pneumoniae and Cytomegalovirus infection on coronary plaques are associated with acute coronary syndromes. Int Heart J 2006; 47 (4): 511–9.
        71. Offenbacher S, Beck JD, Moss K et al. Results from Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol 2009; 80 (2): 190–201.
        72. Oliveira FJ, Vieira RW, Coelho OR et al. Inflamacao sistemica causada pela periodontite cronica em pacientes vitimas de ataque cardiaco isquemico agudo. Rev Bras Cir Cardiovasc 2010; 25 (1): 51–8.
        73. Leishman SJ, Do HL, Ford PJ. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol 2010; 2. doi: 10.3402/jom.v2i0.5781.
        74. Soares GM, Teles F, Starr JR et al. Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model. Antimicrob Agents Chemother 2015; 59 (5): 2791–8.
        75. Socranski S, Haffajee AD. Periodontal microbial ecology. Peridontol 2000. 2005; 38: 135–87.
        76. Olsen I. From the acta prize lecture 2014: the periodontal-systemic connection seen from a microbiological standpoint. Acta Odontol Scand 2015: 1–6.
        77. Pussinen PJ, Nyyssonen K, Alfthan G et al. Serum antibody levels to actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005; 25: 833–8.
        78. Beck JD, Eke P, Lin D et al. Associations between IgG antibody to oral organisms and carotid intima‐medial thickness in community‐dwelling adults. Atherosclerosis 2005; 183: 342–8.
        79. Beck JD, Eke P, Heiss G et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation 2005; 112: 19–24.
        80. Pussinen PJ, Alfthan G, Jousilahti P et al. Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis 2007; 193: 222–8.
        81. Pussinen PJ, Tuomisto K, Jousilahti P et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 2007; 27: 1433–9.
        82. Serra e Silva Filho W, Casarin RC, Nicolela EL. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One 2014; 9 (10): e109761.
        83. Kozarov E, Dorn B, Shelburne C et al. Human atherosclerotic plaque contains viable invasive Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Arterioscler Thromb Vasc Biol 2005; 25: 17–8.
        84. Kozarov Е. Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol 2012; 8 (1): 123–38.
        85. Humphrey LL, Fu R, Buckley DI et al. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med. 2008;23(12):2079–2086.
        86. Gibson FC, Hong C, Chou HH et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E‐deficient mice. Circulation 2004; 109: 2801–6.
        87. Reyes L, Herrera D, Kozarov E et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Periodontol 2013; 84: 30–50.
        88. Jain A, Batista EL, Serhan C et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun 2003; 71: 6012–8.
        89. Page RC. The pathobiology of periodontal disease may affect systemic diseases: inversion of a paradigm. Ann Periodontol 1998; 3 (1): 108–20.
        90. Loos BG, Craandijk J, Hoek FJ et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71 (10): 1528–34.
        91. Badran Z, Struillou X, Verner C et al. Periodontitis as a risk factor for systemic disease: Are microparticles the missing link? Med Hypotheses 2015. pii: S0306-9877(15)00090-0.
        92. Kalburgi V, Sravya L, Warad S et al. Role of systemic markers in periodontal diseases: a possible inflammatory burden and risk factor for cardiovascular diseases? Ann Med Health Sci Res 2014; 4 (3): 388–92.
        93. Sharma A, Astekar M, Metgud R et al. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotech Histochem 2014; 89 (8): 577–82.
        94. Ramirez JH, Parra B, Gutierrez S et al. Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study. Aust Dent J 2014; 59 (1): 29–36.
        95. Lira-Junior R, Figueredo CM, Bouskela E, Fischer RG. Severe chronic periodontitis is associated with endothelial and microvascular dysfunctions: a pilot study. J Periodontol 2014; 85 (12): 1648–57.
        96. Cotti E, Zedda A, Deidda M et al. Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women. J Endod 2015; 41 (5): 594–600.
        97. Saffi MA, Furtado MV, Polanczyk CA et al. Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article. World J Cardiol 2015; 7 (1): 26–30.
        98. Kimura K, Takase B. Significant association between periodontitis and cardiovascular risk. Circ J 2014; 78 (4): 837–8.
        99. Reichert S, Schlitt A, Beschow V et al. Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease. J Periodontal Res 2015; 50 (2): 180–8.
        100. Caula AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875–82.
        101. Lopez NJ, Quintero A, Casanova PA et al. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial. J Periodontol 2012; 83 (3): 267–78.
        102. Cullinan MP, Palmer JE, Faddy MJ et al. The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): a Randomised Controlled Trial. J Periodontol 2015: 1–14.
        103. Hasturk H, Abdallah R, Kantarci A et al. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol 2015; 35 (5): 1123–33.
        104. Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Dis 2000; 13 (3): 227–32.
        105. Kinane DF, Lowe GD. How periodontal disease may contribute to cardiovascular disease. Periodontol 2000; 23: 121–6.
        106. Trukhan L.Iu., Trukhan D.I., Viktorova I.A. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Sprav. poliklin. vracha. 2011; 7: 8–14. [in Russian]
        107. Trukhan D.I., Tarasova L.V., Trukhan L.Iu. Izmeneniia organov i tkanei polosti rta pri zabolevaniiakh serdechno-sosudistoi sistemy i soedinitel'noi tkani, i ikh lekarstvennoi terapii. Consilium Medicum. 2014; 1: 79–82. [in Russian]
        108. Aronov D.M. Pleiotropnye effekty statinov. Kardiologiia. 2008; 8: 60–8. [in Russian]
        109. Ray KK, Cannon CP. The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes. J Am Coll Cardiol 2005; 46: 1425–33.
        110. Estanislau IM, Terceiro IR, Lisboa MR et al. Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review. Br J Clin Pharmacol 2014. doi: 10.1111/bcp.12564.
        111. Subramanian S, Emami H, Vucic E. et al. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. J Am Coll Cardiol 2013; 62 (25): 2382–91.

        Авторы
        Д.И.Трухан*, Л.Ю.Трухан

        ГБОУ ВПО Омская государственная медицинская академия Минздрава России. 644099, Россия, Омск, ул. Ленина, д. 12
        *dmitry_trukhan@mail.ru

        ________________________________________________

        D.I.Trukhan*, L.Yu.Trukhan

        Omsk State Medical Academy of the Ministry of Health of the Russian Federation. 644099, Russian Federation, Omsk, ul. Lenina, d. 12
        *dmitry_trukhan@mail.ru


        Поделиться
        Назад к списку
        Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.

        Ключевые слова

        артериальная гипертензия дети артериальная гипертония лечение сахарный диабет COVID-19 ишемическая болезнь сердца диагностика беременность ожирение сердечно-сосудистые заболевания хроническая сердечная недостаточность рак молочной железы факторы риска метаболический синдром хроническая болезнь почек хроническая обструктивная болезнь легких качество жизни профилактика сахарный диабет 2-го типа фибрилляция предсердий инфаркт миокарда антигипертензивная терапия бесплодие прогноз сердечная недостаточность химиотерапия атеросклероз бронхиальная астма таргетная терапия неалкогольная жировая болезнь печени эффективность амлодипин бактериальный вагиноз витамин D нестероидные противовоспалительные препараты гастроэзофагеальная рефлюксная болезнь ревматоидный артрит вирус папилломы человека коморбидность безопасность реабилитация пробиотики эндометриоз болезнь Крона атопический дерматит инсулинорезистентность эндотелиальная дисфункция язвенный колит инсульт
        Узнавайте первым
        Подпишитесь, чтобы получать информацию о самых интересных событиях, последних новостях.
        Рассылка
        Новости
        Мероприятия
        Актуальные вебинары, конференции, семинары и т.д.
        Медиатека
        Записи вебинаров, подкасты, статьи и интервью.
        Библиотека
        Материалы для врачей-клиницистов:
        — Электронная...
        Наши контакты
        +7 (495) 098-03-59
        Заказать звонок
        Москва 125252, ул. Алабяна 13, корпус 1
        info@omnidoctor.ru
        Портал
        О портале
        История
        Лицензии
        Партнеры
        Реквизиты
        Об издательстве "Консилиум Медикум"
        Политика обработки ПД
        Пресс-центр
        Медиатека
        Библиотека
        Издания для врачей
        Издания для провизоров и фармацевтов
        Online-издания
        Мероприятия
        © 2025 Все права защищены.
        Ближайшее мероприятие
        Ключевые аспекты поддерживающей терапии на пути онкологического пациента
        Ближайшее мероприятие
        x
        Ключевые аспекты поддерживающей терапии на пути онкологического пациента
        Круглый стол
        Онкологические заболевания
        18 декабря 2025 16:00

        Эксперты врачи-онкологи Сарманаева Р.Р. и Пак М.Б. подробно разберут, что может изменить подход к терапии — на всем пути онкологического пациента.

        Присоединяйтесь к прямому эфиру и получите полезные бонусы:
        + материалы для пациентов: кулинарные рецепты, кулинарное шоу,  полезные проекты для пациентов и их близких
        + калькулятор по расчёту риска нутритивной недостаточности
        + полезные статьи 

        Принять участие
        Подождите секунду, мы ищем Расширенный поиск
        Мы используем инструмент веб-аналитики Яндекс Метрика, который посредством обработки файлов «cookie» позволяет анализировать данные о посещаемости сайта, что помогает нам улучшить работу сайта, повысить его удобство и производительность. Соответственно, продолжая пользоваться сайтом, вы соглашаетесь на использование файлов «cookie» и их дальнейшую обработку сервисом Яндекс Метрика. Вы можете блокировать и (или) удалять файлы «cookie» в настройках своего веб-браузера.
        Я согласен(-на)