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Опыт применения препаратов аморолфина в терапии онихомикоза
Опыт применения препаратов аморолфина в терапии онихомикоза
Сонин Д.Б., Тарасова М.А., Борискина Л.А., Буданцева М.В. Опыт применения препаратов аморолфина в терапии онихомикоза. Consilium Medicum. Дерматология (Прил.). 2015; 1: 42–46.
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Аннотация
Представлены результаты клинического сравнительного исследования в 4 центрах по оценке эффективности, безопасности и переносимости препаратов Офломил Лак и Лоцерил у пациентов с онихомикозом пальцев ног легкой и средней степени. В исследовании участвовали 233 пациента, равномерно распределенные на 2 сопоставимые группы. 100% пациентов достигли микологического выздоровления. Полное восстановление ногтевых пластинок достигнуто у 77,5% больных в основной группе и 76% пациентов – в контрольной. Частичное восстановление ногтевых пластинок отмечено у 22,5% лиц в основной группе и 24% – в контрольной. Продолжительность терапии составила от 12 до 36 нед.
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Полный текст
Список литературы
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2. Kubanova A.A., Potekaev N.S., Potekaev N.N. Rukovodstvo po prakticheskoi mikologii. M.: Delovoi ekspress, 2001; s. 24–5; 71–84. [in Russian]
3. Reich A, Szepietowski JC. Quality of Life in Toenail Onychomycosis. Handbook of Disease Burdens and Quality of Life Measures 2010; 3 (3.8): 3837–50.
4. Roberts DT, Taylor WD, Boyle J. Guidelines for treatment of onychomycosis. Br J Dermatol 2003; 148: 402–10.
5. Welsh O, Vera-Cabrera L, Welsh E. Onychomycosis. Clinics in Dermatology. Mycology 2010; 28 (2): 151–9.
6. Gupta AK, Scher RK, De Doncker P. Current management of onychomycosis: An overview. Dermatol Clin 1997; 15 (1): 121–35.
7. Sergeev A.Iu. Gribkovye infektsii. Rukovodstvo dlia vrachei. 2-e izd. M.: BINOM-Press, 2008. [in Russian]
8. Mestnaia i kombinirovannaia terapiia onikhomikozov. Pod red. Iu.V.Sergeeva. Izdano v Rossiiskoi Federatsii v ramkakh programmy i po rekomendatsii Uchenogo Soveta Natsional'noi akademii mikologii. M.: Natsional'naia akademiia mikologii, 2003. [in Russian]
9. Summary of Product Characteristics of Loceryl 5% w/v Medicated Nail Lacquer. Last updated on the eMC: 22/06/2010.
10. Favre B et al. Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay. J Clin Microbiol 2003; 41 (10): 4817–9.
11. Neubert RH, Gensbügel C, Jäckel A, Wartewig S. Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails. Pharmazie 2006; 61 (7): 604–7.
12. Polak A. Kinetics of amorolfine in human nails. Mycoses 1993; 36 (3–4): 101–3.
13. Сергеев Ю.В., Сергеев А.Ю. Онихомикозы – грибковые заболевания ногтей. М.: ГЭОТАР-Медицина, 1998.
14. Baran R, Sigurgeirsson B, De Berker D et al. A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement. Br J Dermatol 2007; 157:149–57.
15. Rigopoulos D, Katoulis AC, Ioannides D et al. A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis. Br J Dermatol 2003; 149 (1): 151–6.
16. Sigurgeirsson B, Olafsson JH, Steinsson JT et al. Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years. J Eur Acad Dermatol Venereol 2010; 24 (8): 910–5. Epub 2009 Dec 17.
17. Lauharanta J. Comparative efficacy and safety of amorolfine nail lacquer 2% versus 5% once weekly. Clin Exp Dermatol 1992; 17 (1): 41–3.
18. Reinel D. Topical treatment of onychomycosis with amorolfine 5% nails lacquer: comparative efficacy and tolerability of once and twice weekly use. Dermatology 1992; 184 (1): 21–4.
2. Кубанова А.А., Потекаев Н.С., Потекаев Н.Н. Руководство по практической микологии. М.: Деловой экспресс, 2001; с. 24–5; 71–84. / Kubanova A.A., Potekaev N.S., Potekaev N.N. Rukovodstvo po prakticheskoi mikologii. M.: Delovoi ekspress, 2001; s. 24–5; 71–84. [in Russian]
3. Reich A, Szepietowski JC. Quality of Life in Toenail Onychomycosis. Handbook of Disease Burdens and Quality of Life Measures 2010; 3 (3.8): 3837–50.
4. Roberts DT, Taylor WD, Boyle J. Guidelines for treatment of onychomycosis. Br J Dermatol 2003; 148: 402–10.
5. Welsh O, Vera-Cabrera L, Welsh E. Onychomycosis. Clinics in Dermatology. Mycology 2010; 28 (2): 151–9.
6. Gupta AK, Scher RK, De Doncker P. Current management of onychomycosis: An overview. Dermatol Clin 1997; 15 (1): 121–35.
7. Сергеев А.Ю. Грибковые инфекции. Руководство для врачей. 2-е изд.
М.: БИНОМ-Пресс, 2008. / Sergeev A.Iu. Gribkovye infektsii. Rukovodstvo dlia vrachei. 2-e izd. M.: BINOM-Press, 2008. [in Russian]
8. Местная и комбинированная терапия онихомикозов. Под ред. Ю.В.Сергеева. Издано в Российской Федерации в рамках программы и по рекомендации Ученого Совета Национальной академии микологии. М.: Национальная академия микологии, 2003. / Mestnaia i kombinirovannaia terapiia onikhomikozov. Pod red. Iu.V.Sergeeva. Izdano v Rossiiskoi Federatsii v ramkakh programmy i po rekomendatsii Uchenogo Soveta Natsional'noi akademii mikologii. M.: Natsional'naia akademiia mikologii, 2003. [in Russian]
9. Summary of Product Characteristics of Loceryl 5% w/v Medicated Nail Lacquer. Last updated on the eMC: 22/06/2010.
10. Favre B et al. Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay. J Clin Microbiol 2003; 41 (10): 4817–9.
11. Neubert RH, Gensbügel C, Jäckel A, Wartewig S. Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails. Pharmazie 2006; 61 (7): 604–7.
12. Polak A. Kinetics of amorolfine in human nails. Mycoses 1993; 36 (3–4): 101–3.
13. Сергеев Ю.В., Сергеев А.Ю. Онихомикозы – грибковые заболевания ногтей. М.: ГЭОТАР-Медицина, 1998.
14. Baran R, Sigurgeirsson B, De Berker D et al. A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement. Br J Dermatol 2007; 157:149–57.
15. Rigopoulos D, Katoulis AC, Ioannides D et al. A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis. Br J Dermatol 2003; 149 (1): 151–6.
16. Sigurgeirsson B, Olafsson JH, Steinsson JT et al. Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years. J Eur Acad Dermatol Venereol 2010; 24 (8): 910–5. Epub 2009 Dec 17.
17. Lauharanta J. Comparative efficacy and safety of amorolfine nail lacquer 2% versus 5% once weekly. Clin Exp Dermatol 1992; 17 (1): 41–3.
18. Reinel D. Topical treatment of onychomycosis with amorolfine 5% nails lacquer: comparative efficacy and tolerability of once and twice weekly use. Dermatology 1992; 184 (1): 21–4.
________________________________________________
2. Kubanova A.A., Potekaev N.S., Potekaev N.N. Rukovodstvo po prakticheskoi mikologii. M.: Delovoi ekspress, 2001; s. 24–5; 71–84. [in Russian]
3. Reich A, Szepietowski JC. Quality of Life in Toenail Onychomycosis. Handbook of Disease Burdens and Quality of Life Measures 2010; 3 (3.8): 3837–50.
4. Roberts DT, Taylor WD, Boyle J. Guidelines for treatment of onychomycosis. Br J Dermatol 2003; 148: 402–10.
5. Welsh O, Vera-Cabrera L, Welsh E. Onychomycosis. Clinics in Dermatology. Mycology 2010; 28 (2): 151–9.
6. Gupta AK, Scher RK, De Doncker P. Current management of onychomycosis: An overview. Dermatol Clin 1997; 15 (1): 121–35.
7. Sergeev A.Iu. Gribkovye infektsii. Rukovodstvo dlia vrachei. 2-e izd. M.: BINOM-Press, 2008. [in Russian]
8. Mestnaia i kombinirovannaia terapiia onikhomikozov. Pod red. Iu.V.Sergeeva. Izdano v Rossiiskoi Federatsii v ramkakh programmy i po rekomendatsii Uchenogo Soveta Natsional'noi akademii mikologii. M.: Natsional'naia akademiia mikologii, 2003. [in Russian]
9. Summary of Product Characteristics of Loceryl 5% w/v Medicated Nail Lacquer. Last updated on the eMC: 22/06/2010.
10. Favre B et al. Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay. J Clin Microbiol 2003; 41 (10): 4817–9.
11. Neubert RH, Gensbügel C, Jäckel A, Wartewig S. Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails. Pharmazie 2006; 61 (7): 604–7.
12. Polak A. Kinetics of amorolfine in human nails. Mycoses 1993; 36 (3–4): 101–3.
13. Сергеев Ю.В., Сергеев А.Ю. Онихомикозы – грибковые заболевания ногтей. М.: ГЭОТАР-Медицина, 1998.
14. Baran R, Sigurgeirsson B, De Berker D et al. A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement. Br J Dermatol 2007; 157:149–57.
15. Rigopoulos D, Katoulis AC, Ioannides D et al. A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis. Br J Dermatol 2003; 149 (1): 151–6.
16. Sigurgeirsson B, Olafsson JH, Steinsson JT et al. Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years. J Eur Acad Dermatol Venereol 2010; 24 (8): 910–5. Epub 2009 Dec 17.
17. Lauharanta J. Comparative efficacy and safety of amorolfine nail lacquer 2% versus 5% once weekly. Clin Exp Dermatol 1992; 17 (1): 41–3.
18. Reinel D. Topical treatment of onychomycosis with amorolfine 5% nails lacquer: comparative efficacy and tolerability of once and twice weekly use. Dermatology 1992; 184 (1): 21–4.
Авторы
Д.Б.Сонин*, М.А.Тарасова, Л.А.Борискина, М.В.Буданцева
ГБУ РО Областной клинический кожно-венерологический диспансер. 390046, Россия, Рязань, ул. Спортивная, д. 9
*sonin63@mail.ru
Ryazan State Regional Dermato-Venerological Clinic. 390046, Russian Federation, Ryazan, ul. Sportivnaia, d. 9
*sonin63@mail.ru
ГБУ РО Областной клинический кожно-венерологический диспансер. 390046, Россия, Рязань, ул. Спортивная, д. 9
*sonin63@mail.ru
________________________________________________
Ryazan State Regional Dermato-Venerological Clinic. 390046, Russian Federation, Ryazan, ul. Sportivnaia, d. 9
*sonin63@mail.ru
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