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Болевой синдром при воспалительных заболеваниях глотки и его симптоматическое лечение
Болевой синдром при воспалительных заболеваниях глотки и его симптоматическое лечение
Дербенева М.Л., Гусева А.Л. Болевой синдром при воспалительных заболеваниях глотки и его симптоматическое лечение. Consilium Medicum. Болезни органов дыхания (Прил.). 2015; с. 31–35.
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Аннотация
Боль в горле является симптомом огромного количества заболеваний. В статье обсуждаются особенности диагностики и лечения наиболее распространенных заболеваний, сопровождающихся болью в горле, а также показания и эффективность применения системной и местной обезболивающей терапии. Рассматривается возможность использования для терапии препарата Стрепсилс Интенсив (таблетки для рассасывания).
Ключевые слова: боль в горле, фарингит, симптоматическая терапия, Стрепсилс Интенсив.
Key words: sorethroat, pharyngitis, symptomatic therapy, Strepsils Intensive.
Ключевые слова: боль в горле, фарингит, симптоматическая терапия, Стрепсилс Интенсив.
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Key words: sorethroat, pharyngitis, symptomatic therapy, Strepsils Intensive.
Полный текст
Список литературы
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2. Schachtel BP. Sore throat pain. In: M.M.Portenoy, E.Laska, editors. Advances in pain research and therapy. New York: Raven Press Ltd 1991; 18: 393–407.
3. Chan TV. The patient with sore throat. Med Clin North Am 2010; 94 (5): 923–43. Doi: 10.1016/j.mcna.2010.06.001.
4. Bisno AL. Acute pharyngitis. N Engl J Med 2001; 344 (3): 205–11.
5. Пальчун В.Т., Лучихин Л.А., Крюков А.И. Воспалительные заболевания глотки. М.: ГЭОТАР-Медиа, 2007. / Pal'chun V.T., Luchikhin L.A., Kriukov A.I. Vospalitel'nye zabolevaniia glotki. M.: GEOTAR-Media, 2007. [in Russian]
6. Stock I. Infectious mononucleosis – a "childhood disease" of great medical concern. Med Monatsschr Pharm 2013; 36 (10): 364–8.
7. Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Physician 2004; 70 (7): 1279–87.
8. Ebell MH, White LL, Casault T. A systematic review of the history and physical examination to diagnose influenza. J Am Board Fam Pract 2004; 17: 1–5.
9. Glezen WP. Herd protection against influenza. J Clin Virol 2006; 37 (4): 237–43.
10. Ahmed F, Singleton JA, Franks AL. Clinical practice. Influenza vaccination for healthy young adults. N Engl J Med 2001; 345 (21): 1543–7.
11. Bridges CB, Fukuda K, Cox NJ, Singleton JA. Advisory Committee on Immunization Practices. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2001; 50 (RR-4): 1–44.
12. Jefferson T, Jones M, Doshi P, Del Mar C. Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis. BMJ 2009; 339: b5106. Doi: 10.1136/bmj.b5106.
13. Hayden FG, Belshe R, Villanueva C et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis. J Infect Dis 2004; 189 (3): 440–9.
14. Komaroff AL, Pass TM, Aronson MD et al. The prediction of streptococcal pharyngitis in adults. J Gen Intern Med 1986; 1 (1): 1–7.
15. Regoli M, Chiappini E, Bonsignori F et al. Update on the management of acute pharyngitis in children. Ital J Pediatr 2011; 37: 10. Doi: 10.1186/1824-7288-37-10.
16. Walsh BT, Bookheim WW, Johnson RC, Tompkins RK. Recognition of streptococcal pharyngitis in adults. Arch Intern Med 1975; 135 (11): 1493–7.
17. Van Driel ML, De Sutter A, Deveugele M et al. Are sore throat patients who hope for antibiotics actually asking for pain relief? Ann Fam Med 2006; 4 (6): 494–9.
18. Burnett I, Schachtel B, Sanner K et al. Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. Clin Ther 2006; 28 (9): 1273–8.
19. Насонов Е.Л. Противовоспалительная терапия ревматических болезней. М.: М-СИТИ, 1996. / Nasonov E.L. Protivovospalitel'naia terapiia revmaticheskikh boleznei. M.: M-SITI, 1996. [in Russian]
20. Korb K, Scherer M, Chenot JF. Steroids as adjuvant therapy for acute pharyngitis in ambulatory patients: a systematic review. Ann Fam Med 2010; 8 (1): 58–63. Doi: 10.1370/afm.1038.
21. Limb M, Connor A, Pickford M et al. Scintigraphy can be used to compare delivery of sore throat formulations. Int J Clin Pract 2009; 63 (4): 606–12. Doi: 10.1111/j.1742-1241.2008.01984.x.
22. Карпищенко С.А., Колесникова О.М. Местное применение нестероидных противовоспалительных препаратов в лечении острого фарингита. Врач. 2012; 12: 34–8. / Karpishchenko S.A., Kolesnikova O.M. Mestnoe primenenie nesteroidnykh protivovospalitel'nykh preparatov v lechenii ostrogo faringita. Vrach. 2012; 12: 34–8. [in Russian]
23. Benrimoj SI, Langford JH, Christian J et al. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75 mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3): 183–93.
24. Blagden M, Christian J, Miller K. Charlesworth A. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres. Int J Clin Pract 2002; 56 (2): 95–100.
2. Schachtel BP. Sore throat pain. In: M.M.Portenoy, E.Laska, editors. Advances in pain research and therapy. New York: Raven Press Ltd 1991; 18: 393–407.
3. Chan TV. The patient with sore throat. Med Clin North Am 2010; 94 (5): 923–43. Doi: 10.1016/j.mcna.2010.06.001.
4. Bisno AL. Acute pharyngitis. N Engl J Med 2001; 344 (3): 205–11.
5. Pal'chun V.T., Luchikhin L.A., Kriukov A.I. Vospalitel'nye zabolevaniia glotki. M.: GEOTAR-Media, 2007. [in Russian]
6. Stock I. Infectious mononucleosis – a "childhood disease" of great medical concern. Med Monatsschr Pharm 2013; 36 (10): 364–8.
7. Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Physician 2004; 70 (7): 1279–87.
8. Ebell MH, White LL, Casault T. A systematic review of the history and physical examination to diagnose influenza. J Am Board Fam Pract 2004; 17: 1–5.
9. Glezen WP. Herd protection against influenza. J Clin Virol 2006; 37 (4): 237–43.
10. Ahmed F, Singleton JA, Franks AL. Clinical practice. Influenza vaccination for healthy young adults. N Engl J Med 2001; 345 (21): 1543–7.
11. Bridges CB, Fukuda K, Cox NJ, Singleton JA. Advisory Committee on Immunization Practices. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2001; 50 (RR-4): 1–44.
12. Jefferson T, Jones M, Doshi P, Del Mar C. Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis. BMJ 2009; 339: b5106. Doi: 10.1136/bmj.b5106.
13. Hayden FG, Belshe R, Villanueva C et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis. J Infect Dis 2004; 189 (3): 440–9.
14. Komaroff AL, Pass TM, Aronson MD et al. The prediction of streptococcal pharyngitis in adults. J Gen Intern Med 1986; 1 (1): 1–7.
15. Regoli M, Chiappini E, Bonsignori F et al. Update on the management of acute pharyngitis in children. Ital J Pediatr 2011; 37: 10. Doi: 10.1186/1824-7288-37-10.
16. Walsh BT, Bookheim WW, Johnson RC, Tompkins RK. Recognition of streptococcal pharyngitis in adults. Arch Intern Med 1975; 135 (11): 1493–7.
17. Van Driel ML, De Sutter A, Deveugele M et al. Are sore throat patients who hope for antibiotics actually asking for pain relief? Ann Fam Med 2006; 4 (6): 494–9.
18. Burnett I, Schachtel B, Sanner K et al. Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. Clin Ther 2006; 28 (9): 1273–8.
19. Nasonov E.L. Protivovospalitel'naia terapiia revmaticheskikh boleznei. M.: M-SITI, 1996. [in Russian]
20. Korb K, Scherer M, Chenot JF. Steroids as adjuvant therapy for acute pharyngitis in ambulatory patients: a systematic review. Ann Fam Med 2010; 8 (1): 58–63. Doi: 10.1370/afm.1038.
21. Limb M, Connor A, Pickford M et al. Scintigraphy can be used to compare delivery of sore throat formulations. Int J Clin Pract 2009; 63 (4): 606–12. Doi: 10.1111/j.1742-1241.2008.01984.x.
22. Karpishchenko S.A., Kolesnikova O.M. Mestnoe primenenie nesteroidnykh protivovospalitel'nykh preparatov v lechenii ostrogo faringita. Vrach. 2012; 12: 34–8. [in Russian]
23. Benrimoj SI, Langford JH, Christian J et al. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75 mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3): 183–93.
24. Blagden M, Christian J, Miller K. Charlesworth A. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres. Int J Clin Pract 2002; 56 (2): 95–100.
2. Schachtel BP. Sore throat pain. In: M.M.Portenoy, E.Laska, editors. Advances in pain research and therapy. New York: Raven Press Ltd 1991; 18: 393–407.
3. Chan TV. The patient with sore throat. Med Clin North Am 2010; 94 (5): 923–43. Doi: 10.1016/j.mcna.2010.06.001.
4. Bisno AL. Acute pharyngitis. N Engl J Med 2001; 344 (3): 205–11.
5. Пальчун В.Т., Лучихин Л.А., Крюков А.И. Воспалительные заболевания глотки. М.: ГЭОТАР-Медиа, 2007. / Pal'chun V.T., Luchikhin L.A., Kriukov A.I. Vospalitel'nye zabolevaniia glotki. M.: GEOTAR-Media, 2007. [in Russian]
6. Stock I. Infectious mononucleosis – a "childhood disease" of great medical concern. Med Monatsschr Pharm 2013; 36 (10): 364–8.
7. Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Physician 2004; 70 (7): 1279–87.
8. Ebell MH, White LL, Casault T. A systematic review of the history and physical examination to diagnose influenza. J Am Board Fam Pract 2004; 17: 1–5.
9. Glezen WP. Herd protection against influenza. J Clin Virol 2006; 37 (4): 237–43.
10. Ahmed F, Singleton JA, Franks AL. Clinical practice. Influenza vaccination for healthy young adults. N Engl J Med 2001; 345 (21): 1543–7.
11. Bridges CB, Fukuda K, Cox NJ, Singleton JA. Advisory Committee on Immunization Practices. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2001; 50 (RR-4): 1–44.
12. Jefferson T, Jones M, Doshi P, Del Mar C. Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis. BMJ 2009; 339: b5106. Doi: 10.1136/bmj.b5106.
13. Hayden FG, Belshe R, Villanueva C et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis. J Infect Dis 2004; 189 (3): 440–9.
14. Komaroff AL, Pass TM, Aronson MD et al. The prediction of streptococcal pharyngitis in adults. J Gen Intern Med 1986; 1 (1): 1–7.
15. Regoli M, Chiappini E, Bonsignori F et al. Update on the management of acute pharyngitis in children. Ital J Pediatr 2011; 37: 10. Doi: 10.1186/1824-7288-37-10.
16. Walsh BT, Bookheim WW, Johnson RC, Tompkins RK. Recognition of streptococcal pharyngitis in adults. Arch Intern Med 1975; 135 (11): 1493–7.
17. Van Driel ML, De Sutter A, Deveugele M et al. Are sore throat patients who hope for antibiotics actually asking for pain relief? Ann Fam Med 2006; 4 (6): 494–9.
18. Burnett I, Schachtel B, Sanner K et al. Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. Clin Ther 2006; 28 (9): 1273–8.
19. Насонов Е.Л. Противовоспалительная терапия ревматических болезней. М.: М-СИТИ, 1996. / Nasonov E.L. Protivovospalitel'naia terapiia revmaticheskikh boleznei. M.: M-SITI, 1996. [in Russian]
20. Korb K, Scherer M, Chenot JF. Steroids as adjuvant therapy for acute pharyngitis in ambulatory patients: a systematic review. Ann Fam Med 2010; 8 (1): 58–63. Doi: 10.1370/afm.1038.
21. Limb M, Connor A, Pickford M et al. Scintigraphy can be used to compare delivery of sore throat formulations. Int J Clin Pract 2009; 63 (4): 606–12. Doi: 10.1111/j.1742-1241.2008.01984.x.
22. Карпищенко С.А., Колесникова О.М. Местное применение нестероидных противовоспалительных препаратов в лечении острого фарингита. Врач. 2012; 12: 34–8. / Karpishchenko S.A., Kolesnikova O.M. Mestnoe primenenie nesteroidnykh protivovospalitel'nykh preparatov v lechenii ostrogo faringita. Vrach. 2012; 12: 34–8. [in Russian]
23. Benrimoj SI, Langford JH, Christian J et al. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75 mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3): 183–93.
24. Blagden M, Christian J, Miller K. Charlesworth A. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres. Int J Clin Pract 2002; 56 (2): 95–100.
________________________________________________
2. Schachtel BP. Sore throat pain. In: M.M.Portenoy, E.Laska, editors. Advances in pain research and therapy. New York: Raven Press Ltd 1991; 18: 393–407.
3. Chan TV. The patient with sore throat. Med Clin North Am 2010; 94 (5): 923–43. Doi: 10.1016/j.mcna.2010.06.001.
4. Bisno AL. Acute pharyngitis. N Engl J Med 2001; 344 (3): 205–11.
5. Pal'chun V.T., Luchikhin L.A., Kriukov A.I. Vospalitel'nye zabolevaniia glotki. M.: GEOTAR-Media, 2007. [in Russian]
6. Stock I. Infectious mononucleosis – a "childhood disease" of great medical concern. Med Monatsschr Pharm 2013; 36 (10): 364–8.
7. Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Physician 2004; 70 (7): 1279–87.
8. Ebell MH, White LL, Casault T. A systematic review of the history and physical examination to diagnose influenza. J Am Board Fam Pract 2004; 17: 1–5.
9. Glezen WP. Herd protection against influenza. J Clin Virol 2006; 37 (4): 237–43.
10. Ahmed F, Singleton JA, Franks AL. Clinical practice. Influenza vaccination for healthy young adults. N Engl J Med 2001; 345 (21): 1543–7.
11. Bridges CB, Fukuda K, Cox NJ, Singleton JA. Advisory Committee on Immunization Practices. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2001; 50 (RR-4): 1–44.
12. Jefferson T, Jones M, Doshi P, Del Mar C. Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis. BMJ 2009; 339: b5106. Doi: 10.1136/bmj.b5106.
13. Hayden FG, Belshe R, Villanueva C et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis. J Infect Dis 2004; 189 (3): 440–9.
14. Komaroff AL, Pass TM, Aronson MD et al. The prediction of streptococcal pharyngitis in adults. J Gen Intern Med 1986; 1 (1): 1–7.
15. Regoli M, Chiappini E, Bonsignori F et al. Update on the management of acute pharyngitis in children. Ital J Pediatr 2011; 37: 10. Doi: 10.1186/1824-7288-37-10.
16. Walsh BT, Bookheim WW, Johnson RC, Tompkins RK. Recognition of streptococcal pharyngitis in adults. Arch Intern Med 1975; 135 (11): 1493–7.
17. Van Driel ML, De Sutter A, Deveugele M et al. Are sore throat patients who hope for antibiotics actually asking for pain relief? Ann Fam Med 2006; 4 (6): 494–9.
18. Burnett I, Schachtel B, Sanner K et al. Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. Clin Ther 2006; 28 (9): 1273–8.
19. Nasonov E.L. Protivovospalitel'naia terapiia revmaticheskikh boleznei. M.: M-SITI, 1996. [in Russian]
20. Korb K, Scherer M, Chenot JF. Steroids as adjuvant therapy for acute pharyngitis in ambulatory patients: a systematic review. Ann Fam Med 2010; 8 (1): 58–63. Doi: 10.1370/afm.1038.
21. Limb M, Connor A, Pickford M et al. Scintigraphy can be used to compare delivery of sore throat formulations. Int J Clin Pract 2009; 63 (4): 606–12. Doi: 10.1111/j.1742-1241.2008.01984.x.
22. Karpishchenko S.A., Kolesnikova O.M. Mestnoe primenenie nesteroidnykh protivovospalitel'nykh preparatov v lechenii ostrogo faringita. Vrach. 2012; 12: 34–8. [in Russian]
23. Benrimoj SI, Langford JH, Christian J et al. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75 mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3): 183–93.
24. Blagden M, Christian J, Miller K. Charlesworth A. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres. Int J Clin Pract 2002; 56 (2): 95–100.
Авторы
М.Л.Дербенева*1, А.Л.Гусева2
1 ГБУЗ Городская клиническая больница №1 им. Н.И.Пирогова Департамента здравоохранения г. Москвы. 119049, Россия, Москва, Ленинский пр-т., д. 10, корп. 5;
2 ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*mlderbeneva@mail.ru
1 N.I.Pirogov City clinical hospital №1 of the Department of Health of Moscow. 119049, Russian Federation, Moscow, Leninskii pr-t., d. 10, korp. 5;
2 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*mlderbeneva@mail.ru
1 ГБУЗ Городская клиническая больница №1 им. Н.И.Пирогова Департамента здравоохранения г. Москвы. 119049, Россия, Москва, Ленинский пр-т., д. 10, корп. 5;
2 ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*mlderbeneva@mail.ru
________________________________________________
1 N.I.Pirogov City clinical hospital №1 of the Department of Health of Moscow. 119049, Russian Federation, Moscow, Leninskii pr-t., d. 10, korp. 5;
2 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*mlderbeneva@mail.ru
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