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Значимость местных противовоспалительных препаратов в стартовой терапии боли в горле
Значимость местных противовоспалительных препаратов в стартовой терапии боли в горле
Егорова О.А. Значимость местных противовоспалительных препаратов в стартовой терапии боли в горле. Consilium Medicum. 2016; 18 (11): 67–72. DOI: 10.26442/2075-1753_2016.11.67-72
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Аннотация
Частота назначения антибактериальных препаратов при лечении боли в горле в России неоправданно высока. Боль в горле – одна из наиболее распространенных причин обращения к врачам амбулаторного приема. Назначение системной антибактериальной терапии оправдано только в случае стрептококковой этиологии заболевания. Большое внимание уделяется раннему назначению местных противовоспалительных препаратов, способных предотвратить дальнейшее развитие инфекционного процесса. Основным требованиям отвечает препарат Стрепсилс Интенсив, который не только помогает облегчить боль в горле, но и действует на ее причину – воспаление. Стрепсилс Интенсив обладает двойным действием: противовоспалительным, аналгезирующим.
Ключевые слова: боль в горле, острый тонзиллофарингит, местная противовоспалительная терапия, Стрепсилс Интенсив.
Ключевые слова: боль в горле, острый тонзиллофарингит, местная противовоспалительная терапия, Стрепсилс Интенсив.
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Frequency assignment of antibacterial drugs in the treatment of sore throat in Russia is unreasonably high. Sore throat is one of the most common reasons for visits to doctors for outpatient reception. Purpose of systemic antibiotic therapy is justified only in the case of streptococcal disease etiology. Much attention is paid to the early appointment of the local anti-inflammatory drugs, can prevent further infection. The basic requirements are met by the drug Strepsils Intensive, which not only helps to relieve pain in the throat, but also acts on the cause – inflammation. Strepsils Intensive has a dual action: anti-inflammatory, analgesic.
Key words: sore throat, acute tonsillofaringitis, a local anti-inflammatory therapy, Strepsils Intensive.
Key words: sore throat, acute tonsillofaringitis, a local anti-inflammatory therapy, Strepsils Intensive.
Полный текст
Список литературы
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26. Warson N, Nimmo WS, Christian J et al. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 2000; 54 (8): 490–6.
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2. Kriukov A.I., Kunel'skaia N.L., Turovskii A.B., Izotova G.N. Tonzillofaringity: diagnostika i lechenie. Handbook for Practitioners Doctors. 2007; 1: 58–61. [in Russian]
3. Zakharova I.N., Korovina N.A., Ovsiannikova E.M. Bol' v gorle. Meditsinskii sovet. 2013; 2 (3). [in Russian]
4. Turovskii A.B., Kondrashina V.V. Simptomaticheskaia terapiia pri zabolevaniiakh glotki. Vestn. otorinolaringologii. 2013; 67–9. [in Russian]
5. Soldatskii Iu.L., Onufrieva E.K., Gasparian S.F. i dr. Vybor optimal'nogo sredstva dlia mestnogo lecheniia faringita u detei. Vopr. sovrem. pediatrii. 2012; 11 (2): 94–7. [in Russian]
6. Alcaide ML, Bisno AL. Pharyngitis and epiglottitis. Infect Dis Clin North Am 2007; 21: 449–69.
7. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–95.
8. Spurling GK, Del Mar CB, Dooley L, Foxlee R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev 2007; (3): CD004417.
9. Bisno AL. Pharyngitis. In: Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 6th ed. Philadelpia: Churhill Livingstone, 2005; p. 752–8.
10. Lopatin A.S. Mestnye antimikrobnye preparaty v lechenii infektsii verkhnikh dykhatel'nykh putei. RMZh. 2000; 2: 1–9. [in Russian]
11. Derbeneva M.L., Guseva A.L. Bolevoi sindrom vospalitel'nykh zabolevanii glotki i ego simptomaticheskoe lechenie. Consilium Medicum. Respiratory organs diseases (Suppl.). 2015; 1: 26–31. [in Russian]
12. Vasina A.A. Mestnoe lechenie faringita u detei. Consillium Medicum. Pediatrics (Suppl.). 2014; 4: 60–3. [in Russian]
13. Portier H, Grappin M, Chavanet P. New strategies for angina casemanagement in France. Bull Acad Natl Med 2003; 187 (6): 1107–16.
14. Moore N, Le Parc JM, van Ganse E et al. Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. Int J Clin Pract 2002; 56 (10): 732–4.
15. Zaitsev A.A., Karpov O.I. Flurbiprofen pri boliakh v gorle. Lechashchii vrach. 2003; 8. [in Russian]
16. Vane JR, Botting RM. Overview: the mechanism of action of antiinflammatory drugs. Clinical significance and potential of selective COX-2 inhibitors. Ed. Vane JR, Botting RM. William Harvey Press, 1998; р. 1–18.
17. Ferreira SH. Blockade of inflammatory hyperalgesia and cyclooxygenase-2. In.: New targets in inflammation. Inhibitors of COX-2 or adhesion molecules. Ed. Bazan N, Botting J, Vane J. Kluwer Acad Press, 1996: 39–45.
18. Karpov O.I., Zaitsev A.A. Nesteroidnye protivovospalitel'nye preparaty – aspekty bezopasnosti dlitel'nogo primeneniia. Novye Sankt-Peterburgskie vrachebnye vedomosti. 2001; 4: 79–82. [in Russian]
19. Arcimowicz M, Samolinski B, Gotlib T, Nyckowska J. Nimesulide - the selective COX-2 inhibitor in the treatment of ENT diseases. Otolaryngol Pol 2002; 56: 501–7.
20. Weckx LL, Ruiz JE, Duperly J. Efficacy of celecoxib in treating symptoms of viral pharyngitis: a double-blind, randomized study of celecoxib versus diclofenac. J Int Med Res 2002; 30 (2): 185–94.
21. Davies NM. Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet 1995; 28 (2): 100–14.
22. Droge MJ, van Sorge AA, van Haeringen NJ et al. Alternative splicing of cyclooxygenase-1 mRNA in the human iris. Ophthalmic Res 2003; 35 (3): 160–3.
23. Fang JY, Hwang TL, Fang CL, Chiu HC. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int J Pharm 2003; 255 (1–2): 153–66.
24. Balabanova R.M. Strepfen (flurbiprofen) – preparat dlia simptomaticheskoi terapii bolei v gorle. RMZh. 2003; 11 (22): 1220–3. [in Russian]
25. Benrimoj SI et al. Efficacy and tolerability of the anti-inflammatory throat lozenge flurbiprofen 8.75 mg in the treatment of sore throat – a randomized, double-blind, placebo-controlled study. Clin Drug Invest 2001; 21 (3): 183–93.
26. Warson N, Nimmo WS, Christian J et al. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 2000; 54 (8): 490–6.
27. Benrimoj SI, Langford JH. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3).
28. Russo M, Bloch M, de Looze F at al. Flurbiprofenmicrogranules for relief of sore throat: a randomised, double-blind trial. Br J Gen Pract 2013; 63 (607): e149–e155 (7).
29. Schacbtel BP, Homan HD, Gibb IA et al. Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model. Clin Pharmacol Ther 2002; 71 (5): 375–80.
30. Battist N. The evaluation of the analgesic and anti–inflammatory effects of flurbiprofen mouth wash and 100 mg tablets in oral medicine. Minerva Stomatol 1994; 43 (4): 141–4.
31. Heasman PA, Benn DK, Kelly PJ et al. The use of topical flurbiprofen as an adjunct to non–surgical management of periodontal disease. J Clin Periodontal 1993; 20 (6): 457–64.
32. Vishniakov V.V. Sovremennye podkhody k diagnostike i lecheniiu ostrykh vospalitel'nykh zabolevanii glotki (rezul'taty klinicheskogo issledovaniia). Consillium Medicum. 2016; 18 (3): 80–5. [in Russian]
33. Kolesnikova O.M. Lechenie postintubatsionnoi boli v gorle. Consillium Medicum. 2015; 17 (3): 42–5. [in Russian]
34. Trubushkina E.M., Koshel' V.I. Bol' v gorle. Primenenie preparata Strepsils Intensiv (flurbiprofen). RMZh. 2015; 4: 202. [in Russian]
35. Bozhko A.V. Kompleksnoe lechenie bol'nykh s obostreniem khronicheskogo gipertroficheskogo faringita. Lechashchii vrach. 2007; 2. [in Russian]
36. Biriukova T.L. Vozmozhnosti simptomaticheskogo lecheniia boli v gorle. Consilium provisorum. 2005; 4 (4): 13–4. [in Russian]
37. Makhlinovskaia N.V., Salpagarova M.M. Opyt primeneniia preparatov Ctrepfen (Strepsils Intensiv) i Strepsils plius sprei pri ostrykh vospalitel'nykh protsessakh v glotke. Novosti meditsiny i farmatsii. 2011; 17: 386 [in Russian]
38. Mal'tseva G.S. Ostryi faringit: vozmozhnosti lokal'noi terapii. Consilium Medicum. 2012; 14 (11): 22–5. [in Russian]
39. http://www.provizor-online.ru/2013/08/strepsils_intensiv_Strepsils_intensiv
40. Instruktsiia po meditsinskomu primeneniiu preparata Strepsils Intensiv. [in Russian]
2. Крюков А.И., Кунельская Н.Л., Туровский А.Б., Изотова Г.Н. Тонзиллофарингиты: диагностика и лечение. Справочник поликлинического врача. 2007; 1: 58–61. / Kriukov A.I., Kunel'skaia N.L., Turovskii A.B., Izotova G.N. Tonzillofaringity: diagnostika i lechenie. Handbook for Practitioners Doctors. 2007; 1: 58–61. [in Russian]
3. Захарова И.Н., Коровина Н.А., Овсянникова Е.М. Боль в горле. Медицинский совет. 2013; 2 (3). / Zakharova I.N., Korovina N.A., Ovsiannikova E.M. Bol' v gorle. Meditsinskii sovet. 2013; 2 (3). [in Russian]
4. Туровский А.Б., Кондрашина В.В. Симптоматическая терапия при заболеваниях глотки. Вестн. оториноларингологии. 2013; 67–9. / Turovskii A.B., Kondrashina V.V. Simptomaticheskaia terapiia pri zabolevaniiakh glotki. Vestn. otorinolaringologii. 2013; 67–9. [in Russian]
5. Солдатский Ю.Л., Онуфриева Е.К., Гаспарян С.Ф. и др. Выбор оптимального средства для местного лечения фарингита у детей. Вопр. соврем. педиатрии. 2012; 11 (2): 94–7. / Soldatskii Iu.L., Onufrieva E.K., Gasparian S.F. i dr. Vybor optimal'nogo sredstva dlia mestnogo lecheniia faringita u detei. Vopr. sovrem. pediatrii. 2012; 11 (2): 94–7. [in Russian]
6. Alcaide ML, Bisno AL. Pharyngitis and epiglottitis. Infect Dis Clin North Am 2007; 21: 449–69.
7. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–95.
8. Spurling GK, Del Mar CB, Dooley L, Foxlee R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev 2007; (3): CD004417.
9. Bisno AL. Pharyngitis. In: Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 6th ed. Philadelpia: Churhill Livingstone, 2005; p. 752–8.
10. Лопатин А.С. Местные антимикробные препараты в лечении инфекций верхних дыхательных путей. РМЖ. 2000; 2: 1–9. / Lopatin A.S. Mestnye antimikrobnye preparaty v lechenii infektsii verkhnikh dykhatel'nykh putei. RMZh. 2000; 2: 1–9. [in Russian]
11. Дербенева М.Л., Гусева А.Л. Болевой синдром воспалительных заболеваний глотки и его симптоматическое лечение. Consillium Medicum. Болезни органов дыхания (Прил.). 2015; 1: 26–31. / Derbeneva M.L., Guseva A.L. Bolevoi sindrom vospalitel'nykh zabolevanii glotki i ego simptomaticheskoe lechenie. Consilium Medicum. Respiratory organs diseases (Suppl.). 2015; 1: 26–31. [in Russian]
12. Васина А.А. Местное лечение фарингита у детей. Consillium Medicum. Педиатрия (Прил.). 2014; 4: 60–3. / Vasina A.A. Mestnoe lechenie faringita u detei. Consillium Medicum. Pediatrics (Suppl.). 2014; 4: 60–3. [in Russian]
13. Portier H, Grappin M, Chavanet P. New strategies for angina casemanagement in France. Bull Acad Natl Med 2003; 187 (6): 1107–16.
14. Moore N, Le Parc JM, van Ganse E et al. Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. Int J Clin Pract 2002; 56 (10): 732–4.
15. Зайцев А.А., Карпов О.И. Флурбипрофен при болях в горле. Лечащий врач. 2003; 8. / Zaitsev A.A., Karpov O.I. Flurbiprofen pri boliakh v gorle. Lechashchii vrach. 2003; 8. [in Russian]
16. Vane JR, Botting RM. Overview: the mechanism of action of antiinflammatory drugs. Clinical significance and potential of selective COX-2 inhibitors. Ed. Vane JR, Botting RM. William Harvey Press, 1998; р. 1–18.
17. Ferreira SH. Blockade of inflammatory hyperalgesia and cyclooxygenase-2. In.: New targets in inflammation. Inhibitors of COX-2 or adhesion molecules. Ed. Bazan N, Botting J, Vane J. Kluwer Acad Press, 1996: 39–45.
18. Карпов О.И., Зайцев А.А. Нестероидные противовоспалительные препараты – аспекты безопасности длительного применения. Новые Санкт-Петербургские врачебные ведомости. 2001; 4: 79–82. / Karpov O.I., Zaitsev A.A. Nesteroidnye protivovospalitel'nye preparaty – aspekty bezopasnosti dlitel'nogo primeneniia. Novye Sankt-Peterburgskie vrachebnye vedomosti. 2001; 4: 79–82. [in Russian]
19. Arcimowicz M, Samolinski B, Gotlib T, Nyckowska J. Nimesulide - the selective COX-2 inhibitor in the treatment of ENT diseases. Otolaryngol Pol 2002; 56: 501–7.
20. Weckx LL, Ruiz JE, Duperly J. Efficacy of celecoxib in treating symptoms of viral pharyngitis: a double-blind, randomized study of celecoxib versus diclofenac. J Int Med Res 2002; 30 (2): 185–94.
21. Davies NM. Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet 1995; 28 (2): 100–14.
22. Droge MJ, van Sorge AA, van Haeringen NJ et al. Alternative splicing of cyclooxygenase-1 mRNA in the human iris. Ophthalmic Res 2003; 35 (3): 160–3.
23. Fang JY, Hwang TL, Fang CL, Chiu HC. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int J Pharm 2003; 255 (1–2): 153–66.
24. Балабанова Р.М. Стрепфен (флурбипрофен) – препарат для симптоматической терапии болей в горле. РМЖ. 2003; 11 (22): 1220–3. / Balabanova R.M. Strepfen (flurbiprofen) – preparat dlia simptomaticheskoi terapii bolei v gorle. RMZh. 2003; 11 (22): 1220–3. [in Russian]
25. Benrimoj SI et al. Efficacy and tolerability of the anti-inflammatory throat lozenge flurbiprofen 8.75 mg in the treatment of sore throat – a randomized, double-blind, placebo-controlled study. Clin Drug Invest 2001; 21 (3): 183–93.
26. Warson N, Nimmo WS, Christian J et al. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 2000; 54 (8): 490–6.
27. Benrimoj SI, Langford JH. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3).
28. Russo M, Bloch M, de Looze F at al. Flurbiprofenmicrogranules for relief of sore throat: a randomised, double-blind trial. Br J Gen Pract 2013; 63 (607): e149–e155 (7).
29. Schacbtel BP, Homan HD, Gibb IA et al. Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model. Clin Pharmacol Ther 2002; 71 (5): 375–80.
30. Battist N. The evaluation of the analgesic and anti–inflammatory effects of flurbiprofen mouth wash and 100 mg tablets in oral medicine. Minerva Stomatol 1994; 43 (4): 141–4.
31. Heasman PA, Benn DK, Kelly PJ et al. The use of topical flurbiprofen as an adjunct to non–surgical management of periodontal disease. J Clin Periodontal 1993; 20 (6): 457–64.
32. Вишняков В.В. Современные подходы к диагностике и лечению острых воспалительных заболеваний глотки (результаты клинического исследования). Consillium Medicum. 2016; 18 (3): 80–5. / Vishniakov V.V. Sovremennye podkhody k diagnostike i lecheniiu ostrykh vospalitel'nykh zabolevanii glotki (rezul'taty klinicheskogo issledovaniia). Consillium Medicum. 2016; 18 (3): 80–5. [in Russian]
33. Колесникова О.М. Лечение постинтубационной боли в горле. Consillium Medicum. 2015; 17 (3): 42–5. / Kolesnikova O.M. Lechenie postintubatsionnoi boli v gorle. Consillium Medicum. 2015; 17 (3): 42–5. [in Russian]
34. Трубушкина Е.М., Кошель В.И. Боль в горле. Применение препарата Стрепсилс Интенсив (флурбипрофен). РМЖ. 2015; 4: 202. / Trubushkina E.M., Koshel' V.I. Bol' v gorle. Primenenie preparata Strepsils Intensiv (flurbiprofen). RMZh. 2015; 4: 202. [in Russian]
35. Божко А.В. Комплексное лечение больных с обострением хронического гипертрофического фарингита. Лечащий врач. 2007; 2. / Bozhko A.V. Kompleksnoe lechenie bol'nykh s obostreniem khronicheskogo gipertroficheskogo faringita. Lechashchii vrach. 2007; 2. [in Russian]
36. Бирюкова Т.Л. Возможности симптоматического лечения боли в горле.Consilium provisorum. 2005; 4 (4): 13–4. / Biriukova T.L. Vozmozhnosti simptomaticheskogo lecheniia boli v gorle. Consilium provisorum. 2005; 4 (4): 13–4. [in Russian]
37. Махлиновская Н.В., Салпагарова М.М. Опыт применения препаратов Cтрепфен (Стрепсилс Интенсив) и Cтрепсилс плюс спрей при острых воспалительных процессах в глотке. Новости медицины и фармации. 2011; 17: 386. / Makhlinovskaia N.V., Salpagarova M.M. Opyt primeneniia preparatov Ctrepfen (Strepsils Intensiv) i Strepsils plius sprei pri ostrykh vospalitel'nykh protsessakh v glotke. Novosti meditsiny i farmatsii. 2011; 17: 386 [in Russian]
38. Мальцева Г.С. Острый фарингит: возможности локальной терапии. Consilium Medicum. 2012; 14 (11): 22–5. / Mal'tseva G.S. Ostryi faringit: vozmozhnosti lokal'noi terapii. Consilium Medicum. 2012; 14 (11): 22–5. [in Russian]
39. http://www.provizor-online.ru/2013/08/strepsils_intensiv_Strepsils_intensiv
40. Инструкция по медицинскому применению препарата Стрепсилс Интенсив. / Instruktsiia po meditsinskomu primeneniiu preparata Strepsils Intensiv. [in Russian]
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6. Alcaide ML, Bisno AL. Pharyngitis and epiglottitis. Infect Dis Clin North Am 2007; 21: 449–69.
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10. Lopatin A.S. Mestnye antimikrobnye preparaty v lechenii infektsii verkhnikh dykhatel'nykh putei. RMZh. 2000; 2: 1–9. [in Russian]
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12. Vasina A.A. Mestnoe lechenie faringita u detei. Consillium Medicum. Pediatrics (Suppl.). 2014; 4: 60–3. [in Russian]
13. Portier H, Grappin M, Chavanet P. New strategies for angina casemanagement in France. Bull Acad Natl Med 2003; 187 (6): 1107–16.
14. Moore N, Le Parc JM, van Ganse E et al. Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. Int J Clin Pract 2002; 56 (10): 732–4.
15. Zaitsev A.A., Karpov O.I. Flurbiprofen pri boliakh v gorle. Lechashchii vrach. 2003; 8. [in Russian]
16. Vane JR, Botting RM. Overview: the mechanism of action of antiinflammatory drugs. Clinical significance and potential of selective COX-2 inhibitors. Ed. Vane JR, Botting RM. William Harvey Press, 1998; р. 1–18.
17. Ferreira SH. Blockade of inflammatory hyperalgesia and cyclooxygenase-2. In.: New targets in inflammation. Inhibitors of COX-2 or adhesion molecules. Ed. Bazan N, Botting J, Vane J. Kluwer Acad Press, 1996: 39–45.
18. Karpov O.I., Zaitsev A.A. Nesteroidnye protivovospalitel'nye preparaty – aspekty bezopasnosti dlitel'nogo primeneniia. Novye Sankt-Peterburgskie vrachebnye vedomosti. 2001; 4: 79–82. [in Russian]
19. Arcimowicz M, Samolinski B, Gotlib T, Nyckowska J. Nimesulide - the selective COX-2 inhibitor in the treatment of ENT diseases. Otolaryngol Pol 2002; 56: 501–7.
20. Weckx LL, Ruiz JE, Duperly J. Efficacy of celecoxib in treating symptoms of viral pharyngitis: a double-blind, randomized study of celecoxib versus diclofenac. J Int Med Res 2002; 30 (2): 185–94.
21. Davies NM. Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet 1995; 28 (2): 100–14.
22. Droge MJ, van Sorge AA, van Haeringen NJ et al. Alternative splicing of cyclooxygenase-1 mRNA in the human iris. Ophthalmic Res 2003; 35 (3): 160–3.
23. Fang JY, Hwang TL, Fang CL, Chiu HC. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int J Pharm 2003; 255 (1–2): 153–66.
24. Balabanova R.M. Strepfen (flurbiprofen) – preparat dlia simptomaticheskoi terapii bolei v gorle. RMZh. 2003; 11 (22): 1220–3. [in Russian]
25. Benrimoj SI et al. Efficacy and tolerability of the anti-inflammatory throat lozenge flurbiprofen 8.75 mg in the treatment of sore throat – a randomized, double-blind, placebo-controlled study. Clin Drug Invest 2001; 21 (3): 183–93.
26. Warson N, Nimmo WS, Christian J et al. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 2000; 54 (8): 490–6.
27. Benrimoj SI, Langford JH. Efficacy and Tolerability of the Anti-inflammatory Throat Lozenge Flurbiprofen 8.75mg in the Treatment of Sore Throat: A Randomised, Double-Blind, Placebo-Controlled Study. Clin Drug Invest 2001; 21 (3).
28. Russo M, Bloch M, de Looze F at al. Flurbiprofenmicrogranules for relief of sore throat: a randomised, double-blind trial. Br J Gen Pract 2013; 63 (607): e149–e155 (7).
29. Schacbtel BP, Homan HD, Gibb IA et al. Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model. Clin Pharmacol Ther 2002; 71 (5): 375–80.
30. Battist N. The evaluation of the analgesic and anti–inflammatory effects of flurbiprofen mouth wash and 100 mg tablets in oral medicine. Minerva Stomatol 1994; 43 (4): 141–4.
31. Heasman PA, Benn DK, Kelly PJ et al. The use of topical flurbiprofen as an adjunct to non–surgical management of periodontal disease. J Clin Periodontal 1993; 20 (6): 457–64.
32. Vishniakov V.V. Sovremennye podkhody k diagnostike i lecheniiu ostrykh vospalitel'nykh zabolevanii glotki (rezul'taty klinicheskogo issledovaniia). Consillium Medicum. 2016; 18 (3): 80–5. [in Russian]
33. Kolesnikova O.M. Lechenie postintubatsionnoi boli v gorle. Consillium Medicum. 2015; 17 (3): 42–5. [in Russian]
34. Trubushkina E.M., Koshel' V.I. Bol' v gorle. Primenenie preparata Strepsils Intensiv (flurbiprofen). RMZh. 2015; 4: 202. [in Russian]
35. Bozhko A.V. Kompleksnoe lechenie bol'nykh s obostreniem khronicheskogo gipertroficheskogo faringita. Lechashchii vrach. 2007; 2. [in Russian]
36. Biriukova T.L. Vozmozhnosti simptomaticheskogo lecheniia boli v gorle. Consilium provisorum. 2005; 4 (4): 13–4. [in Russian]
37. Makhlinovskaia N.V., Salpagarova M.M. Opyt primeneniia preparatov Ctrepfen (Strepsils Intensiv) i Strepsils plius sprei pri ostrykh vospalitel'nykh protsessakh v glotke. Novosti meditsiny i farmatsii. 2011; 17: 386 [in Russian]
38. Mal'tseva G.S. Ostryi faringit: vozmozhnosti lokal'noi terapii. Consilium Medicum. 2012; 14 (11): 22–5. [in Russian]
39. http://www.provizor-online.ru/2013/08/strepsils_intensiv_Strepsils_intensiv
40. Instruktsiia po meditsinskomu primeneniiu preparata Strepsils Intensiv. [in Russian]
Авторы
О.А.Егорова
ФГБОУ ВО Смоленский государственный медицинский университет Минздрава России. 214019, Россия, Смоленск, ул. Крупской, д. 28;
ОГБУЗ Смоленская областная клиническая больница. 214018, Россия, Смоленск, просп. Гагарина, д. 27
ola-egorova@yandex.ru
ФГБОУ ВО Смоленский государственный медицинский университет Минздрава России. 214019, Россия, Смоленск, ул. Крупской, д. 28;
ОГБУЗ Смоленская областная клиническая больница. 214018, Россия, Смоленск, просп. Гагарина, д. 27
ola-egorova@yandex.ru
________________________________________________
O.A.Egorova
Smolensk State Medical University of the Ministry of Health of the Russian Federation. 214019, Russian Federation, Smolensk, ul. Krupskoi, d. 28;
Smolensk Regional Clinical Hospital. 214018, Russian Federation, Smolensk, prosp. Gagarina, d. 27
ola-egorova@yandex.ru
Smolensk State Medical University of the Ministry of Health of the Russian Federation. 214019, Russian Federation, Smolensk, ul. Krupskoi, d. 28;
Smolensk Regional Clinical Hospital. 214018, Russian Federation, Smolensk, prosp. Gagarina, d. 27
ola-egorova@yandex.ru
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