Особенности применения кандесартана в клинической практике

1. Андрущишина Т.Б., Морозова Т.Е. Антагонисты рецепторов ангиотензина II при лечении кардиоваскулярных заболеваний. Consilium Medicum. 2009; 11 (5): 96–101. / Andrushchishina T.B., Morozova T.E. Antagonisty retseptorov angiotenzina II pri lechenii kardiovaskuliarnykh zabolevanii. Consilium Medicum. 2009; 11 (5): 96–101. [in Russian]
2. Jonston CI. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control. Am J Hypertens 1992; 10: S13–S26.
3. Гиляревский С.Р. Современные возможности блокады ренин-ангиотензиновой системы: остаются ли ингибиторы ангиотензинпревращающего фермента препаратами первого ряда? Consilium Medicum. 2010; 12 (5): 18–23. / Giliarevskii S.R. Sovremennye vozmozhnosti blokady renin-angiotenzinovoi sistemy: ostaiutsia li ingibitory angiotenzinprevrashchaiushchego fermenta preparatami pervogo riada? Consilium Medicum. 2010; 12 (5): 18–23. [in Russian]
4. Остроумова О.Д., Хорьков С.А., Копченов И.И. Возможности антагонистов рецепторов к ангиотензину II в органопротекции у больных с артериальной гипертонией: значение для клинической практики. Consilium Medicum. 2009; 11 (5): 29–37. / Ostroumova O.D., Khor'kov S.A., Kopchenov I.I. Vozmozhnosti antagonistov retseptorov k angiotenzinu II v organoprotektsii u bol'nykh s arterial'noi gipertoniei: znachenie dlia klinicheskoi praktiki. Consilium Medicum. 2009; 11 (5): 29–37. [in Russian]
5. Евдокимова А.Г., Ложкина М.В., Коваленко Е.В., Евдокимов В.В. Клиническая эффективность ирбесартана у пациентов с сердечно-сосудистыми заболеваниями. Сердце. 2012; 11 (6): 364–8. / Evdokimova A.G., Lozhkina M.V., Kovalenko E.V., Evdokimov V.V. Klinicheskaia effektivnost' irbesartana u patsientov s serdechno-sosudistymi zabolevaniiami. Serdtse. 2012; 11 (6): 364–8. [in Russian]
6. Гиляревский С.Р., Голшмид М.В., Кузьмина И.М. Доказательная история кандесартана: прошлое, будущее и настоящее. Сердечная недостаточность. 2015; 16 (5): 303–10. / Giliarevskii S.R., Golshmid M.V., Kuz'mina I.M. Dokazatel'naia istoriia kandesartana: proshloe, budushchee i nastoiashchee. Serdechnaia nedostatochnost'. 2015; 16 (5): 303–10. [in Russian]
7. Сиренко Ю.Н., Донченко Н.В. Место кандесартана в современной терапии сердечно-сосудистых заболеваний: обзор доказательств. Артериальная гипертензия. 2011; 4 (18): 114–26. / Сиренко Ю.Н., Донченко Н.В. Место кандесартана в современной терапии сердечно-сосудистых заболеваний: обзор доказательств. Артериальная гипертензия. 2011; 4 (18): 114–26. [in Russian]
8. Hubner R, Hogemann AM, Sunzel M, Riddell JC. Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexetil in young and elderly healthy volunteers. J Hum Hypertens 1997; 11 (Suppl. 2): S19–S25.
9. Trenkwalder P, Lehlovirta M, Dahl K. Long-term treatment with candesartan cilexetil does not affect glucose homeostasis or serum lipid profile in mild hypertensives with type 2 diabetes. J Hum Hypertens 1999; 13 (Suppl. 1): S81–S83.
10. Inada Y, Ojima M, Kanagawa R et al. Pharmacologic properties of candesartan cilexetil – possible mechanisms of long-term antihypertensive action. J Hum Hypertens 1999; 13 (Suppl. 1): S75–S80.
11. McClellan KJ, Goa KL. Candesartan cilexetil. A review of its use in essential hypertension. Drugs 1998; 56: 847–69.
12. Abrahamsson Т, Karp L, Brabdl-Eliasson II el al. Candesartan causes long-last antagonism of angiotensin II receptor-mediated contractile effects in isolated vascular preparations: a comparison with irbesartan, losartan and its active metabolite (EXP-3174). Blood Pressure 2000; 9 (Abstr. Suppl.): 1–52.
13. Linger T. Differences among angiotensin II type 1 receptor blockers: characterization of candesartan cilexetil. Blood Pressure 2000; 9 (Suppl. 1): 14–8.
14. Vanderheyden PML, Fierens FLP, De Backer JP, Vauquelin G. Reversible and syntopic interaction between angiotensin receptor antagonists on Chinese hamster ovary cells expressing human angiotensin II type I receptors. Biochem Pharmacol 2000; 59: 927–35.
15. Van Liefde I, Vauquelin G. Sartan-AT1 receptor interactions: In vitro evidence for insurmountable antagonism and inverse agonism. Mol Cell Endocrinol 2009; 302: 237–43.
16. Easthope SE, Jarvis B. Candesartan cilexetil: an update of its use in essential hypertension. Drugs 2002; 62: 1253–87.
17. Cuspidi C, Muiesan ML, Valagussa L еt al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. J Hypertens 2002; 20: 2293–300.
18. Ogihara T, Fujimoto A, Nakao K, Saruta T. CASE-J Trial Group. ARB candesartan and CCB amlodipine in hypertensive patients: the CASE-J trial. Exp Rev Cardiovasc Ther 2008; p. 1195–201.
19. Escobar C, Barrios V, Calderon A et al. Electrocardiographic left ventricular hypertrophy regression induced by an angiotensin receptor blocker-based regimen in hypertensive patients with the metabolic syndrome: data from the SARA Study. J Clin Hypertens (Greenwich) 2008; 10: 208–14.
20. Penicka M, Gregor P, Kerekes R et al. Candesartan use in Hypertrophic And Non-obstructive Cardiomyopathy Estate (CHANCE) Study. The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study. J Mol Diagn 2009; 11: 35–41.
21. Lithell H, Hansson L, Skoog I et al. SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21: 875–86.
22. Kasanuki H, Hagiwara N, Hosoda S et al. HIJ-CREATE Investigators. Angiotensin II receptor blockerbased vs. nonangiotensin II receptor blockerbased therapy in patients with angiographically documented coronary artery disease and hypertension: the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease (HIJ-CREATE). Eur Heart J 2009; 30: 1203–12.
23. De Rosa MJ. Angiotensin II receptor blockers and cardioprotection. Vasc Health Risk Manag 2010; 6: 1047–63.
24. Burgess E, Muirhead N, Rene de Cotret P et al. SMART (Supra Maximal Atacand Renal Trial) Investigators. Supramaximal dose of candesartan in proteinuric renal disease. J Am Soc Nephrol 2009; 20: 893–900.
25. Mogensen CE, Neldam S, Tikkanen I et al. For the CALM study group. Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. BMJ 2000; 321: 1440–4.
26. Norris S, Weinstein J, Peterson K, Thakurta S. Drug Class Review. Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers. Drug Effectiveness Review Project. Oregon Health & Science University 2009.
27. Pfeffer MA, Swedberg K, Granger CB et al. For the CHARM Investigators and Committees. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003; 362: 759–66.
28. McMurray JJV, Ostergren J, Swedberg K et al. For the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function taking angiotensin converting enzyme inhibitors: the CHARM-Added trial. Lancet 2003; 362: 767–71.
29. Granger CB, McMurray JJV, Yusuf S et al. For the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function intolerant to angiotensin converting enzyme inhibitors: the CHARM-Alternative trial. Lancet 2003; 362: 772–6.
30. Yusuf S, Pfeffer MA, Swedberg K et al. for the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003; 362: 777–81.
31. Ducharme A, Swedberg K, Pfeffer MA et al. CHARM Investigators. Prevention of atrial fibrillation in patients with symptomatic chronic heart failure by candesartan in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. Am Heart J 2006; 152: 86–92.
32. Grassi G, Seravalle G, Dell’Oro R еt al. For CROSS Study. Comparative effects of candesartan and hydrochlortiazide on blood pressure, insulin sensitivity and sympathetic drive in obese hypertensive individuals: results of the CROSS study. J Hypertens 2003; 21: 1761–9.
33. Ogihara T, Fujimoto A, Nakao K, Saruta T. CASE-J Trial Group. ARB candesartan and CCB amlodipine in hypertensive patients: the CASE-J trial. Exp Rev Cardiovasc Ther 2008; 6 (9): 1195–201.
34. Kasanuki H, Hagiwara N, Hosoda S et al. Angiotensin II receptor blocker-based vs. non-angiotensin II receptor blocker-based therapy in patients with angiographically documented coronary artery disease and hypertension: the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease (HIJ-CREATE). Eur Heart J 2009; 30 (10): 1203–12.
35. Sjolie AK, Porta M, Parving HH et al. The Diabetic REtinopathy Candersantan Trials (DIRECT) Programme: baseline characteristics. JRAAS 2005; 6 (1): 25–32.
36. Suzuki T, Nozawa T, Fujii N et al. Combination therapy of candesartan with statin inhibits progression of atherosclerosis more than statin alone in patients with coronary artery disease. Coron Artery Dis 2011; 22: 352–35.
37. Schrader J, Lüders S, Kulschewski A et al. Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group. The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors. Stroke 2003; 34: 1699–703.
38. Эффективность приема блокатора рецепторов ангиотензина II кандесартана в острой фазе инсульта: результаты рандомизированного исследования SCAST (Scandinavian Candesartan Acute Stroke Trial). Доказательная кардиология. 2011; 2: 17–25. / Effektivnost' priema blokatora retseptorov angiotenzina II kandesartana v ostroi faze insul'ta: rezul'taty randomizirovannogo issledovaniia SCAST (Scandinavian Candesartan Acute Stroke Trial). Dokazatel'naia kardiologiia. 2011; 2: 17–25. [in Russian]

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1. Andrushchishina T.B., Morozova T.E. Antagonisty retseptorov angiotenzina II pri lechenii kardiovaskuliarnykh zabolevanii. Consilium Medicum. 2009; 11 (5): 96–101. [in Russian]
2. Jonston CI. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control. Am J Hypertens 1992; 10: S13–S26.
3. Giliarevskii S.R. Sovremennye vozmozhnosti blokady renin-angiotenzinovoi sistemy: ostaiutsia li ingibitory angiotenzinprevrashchaiushchego fermenta preparatami pervogo riada? Consilium Medicum. 2010; 12 (5): 18–23. [in Russian]
4. Ostroumova O.D., Khor'kov S.A., Kopchenov I.I. Vozmozhnosti antagonistov retseptorov k angiotenzinu II v organoprotektsii u bol'nykh s arterial'noi gipertoniei: znachenie dlia klinicheskoi praktiki. Consilium Medicum. 2009; 11 (5): 29–37. [in Russian]
5. Evdokimova A.G., Lozhkina M.V., Kovalenko E.V., Evdokimov V.V. Klinicheskaia effektivnost' irbesartana u patsientov s serdechno-sosudistymi zabolevaniiami. Serdtse. 2012; 11 (6): 364–8. [in Russian]
6. Giliarevskii S.R., Golshmid M.V., Kuz'mina I.M. Dokazatel'naia istoriia kandesartana: proshloe, budushchee i nastoiashchee. Serdechnaia nedostatochnost'. 2015; 16 (5): 303–10. [in Russian]
7. Сиренко Ю.Н., Донченко Н.В. Место кандесартана в современной терапии сердечно-сосудистых заболеваний: обзор доказательств. Артериальная гипертензия. 2011; 4 (18): 114–26. [in Russian]
8. Hubner R, Hogemann AM, Sunzel M, Riddell JC. Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexetil in young and elderly healthy volunteers. J Hum Hypertens 1997; 11 (Suppl. 2): S19–S25.
9. Trenkwalder P, Lehlovirta M, Dahl K. Long-term treatment with candesartan cilexetil does not affect glucose homeostasis or serum lipid profile in mild hypertensives with type 2 diabetes. J Hum Hypertens 1999; 13 (Suppl. 1): S81–S83.
10. Inada Y, Ojima M, Kanagawa R et al. Pharmacologic properties of candesartan cilexetil – possible mechanisms of long-term antihypertensive action. J Hum Hypertens 1999; 13 (Suppl. 1): S75–S80.
11. McClellan KJ, Goa KL. Candesartan cilexetil. A review of its use in essential hypertension. Drugs 1998; 56: 847–69.
12. Abrahamsson Т, Karp L, Brabdl-Eliasson II el al. Candesartan causes long-last antagonism of angiotensin II receptor-mediated contractile effects in isolated vascular preparations: a comparison with irbesartan, losartan and its active metabolite (EXP-3174). Blood Pressure 2000; 9 (Abstr. Suppl.): 1–52.
13. Linger T. Differences among angiotensin II type 1 receptor blockers: characterization of candesartan cilexetil. Blood Pressure 2000; 9 (Suppl. 1): 14–8.
14. Vanderheyden PML, Fierens FLP, De Backer JP, Vauquelin G. Reversible and syntopic interaction between angiotensin receptor antagonists on Chinese hamster ovary cells expressing human angiotensin II type I receptors. Biochem Pharmacol 2000; 59: 927–35.
15. Van Liefde I, Vauquelin G. Sartan-AT1 receptor interactions: In vitro evidence for insurmountable antagonism and inverse agonism. Mol Cell Endocrinol 2009; 302: 237–43.
16. Easthope SE, Jarvis B. Candesartan cilexetil: an update of its use in essential hypertension. Drugs 2002; 62: 1253–87.
17. Cuspidi C, Muiesan ML, Valagussa L еt al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. J Hypertens 2002; 20: 2293–300.
18. Ogihara T, Fujimoto A, Nakao K, Saruta T. CASE-J Trial Group. ARB candesartan and CCB amlodipine in hypertensive patients: the CASE-J trial. Exp Rev Cardiovasc Ther 2008; p. 1195–201.
19. Escobar C, Barrios V, Calderon A et al. Electrocardiographic left ventricular hypertrophy regression induced by an angiotensin receptor blocker-based regimen in hypertensive patients with the metabolic syndrome: data from the SARA Study. J Clin Hypertens (Greenwich) 2008; 10: 208–14.
20. Penicka M, Gregor P, Kerekes R et al. Candesartan use in Hypertrophic And Non-obstructive Cardiomyopathy Estate (CHANCE) Study. The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study. J Mol Diagn 2009; 11: 35–41.
21. Lithell H, Hansson L, Skoog I et al. SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21: 875–86.
22. Kasanuki H, Hagiwara N, Hosoda S et al. HIJ-CREATE Investigators. Angiotensin II receptor blockerbased vs. nonangiotensin II receptor blockerbased therapy in patients with angiographically documented coronary artery disease and hypertension: the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease (HIJ-CREATE). Eur Heart J 2009; 30: 1203–12.
23. De Rosa MJ. Angiotensin II receptor blockers and cardioprotection. Vasc Health Risk Manag 2010; 6: 1047–63.
24. Burgess E, Muirhead N, Rene de Cotret P et al. SMART (Supra Maximal Atacand Renal Trial) Investigators. Supramaximal dose of candesartan in proteinuric renal disease. J Am Soc Nephrol 2009; 20: 893–900.
25. Mogensen CE, Neldam S, Tikkanen I et al. For the CALM study group. Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. BMJ 2000; 321: 1440–4.
26. Norris S, Weinstein J, Peterson K, Thakurta S. Drug Class Review. Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers. Drug Effectiveness Review Project. Oregon Health & Science University 2009.
27. Pfeffer MA, Swedberg K, Granger CB et al. For the CHARM Investigators and Committees. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003; 362: 759–66.
28. McMurray JJV, Ostergren J, Swedberg K et al. For the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function taking angiotensin converting enzyme inhibitors: the CHARM-Added trial. Lancet 2003; 362: 767–71.
29. Granger CB, McMurray JJV, Yusuf S et al. For the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function intolerant to angiotensin converting enzyme inhibitors: the CHARM-Alternative trial. Lancet 2003; 362: 772–6.
30. Yusuf S, Pfeffer MA, Swedberg K et al. for the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003; 362: 777–81.
31. Ducharme A, Swedberg K, Pfeffer MA et al. CHARM Investigators. Prevention of atrial fibrillation in patients with symptomatic chronic heart failure by candesartan in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. Am Heart J 2006; 152: 86–92.
32. Grassi G, Seravalle G, Dell’Oro R еt al. For CROSS Study. Comparative effects of candesartan and hydrochlortiazide on blood pressure, insulin sensitivity and sympathetic drive in obese hypertensive individuals: results of the CROSS study. J Hypertens 2003; 21: 1761–9.
33. Ogihara T, Fujimoto A, Nakao K, Saruta T. CASE-J Trial Group. ARB candesartan and CCB amlodipine in hypertensive patients: the CASE-J trial. Exp Rev Cardiovasc Ther 2008; 6 (9): 1195–201.
34. Kasanuki H, Hagiwara N, Hosoda S et al. Angiotensin II receptor blocker-based vs. non-angiotensin II receptor blocker-based therapy in patients with angiographically documented coronary artery disease and hypertension: the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease (HIJ-CREATE). Eur Heart J 2009; 30 (10): 1203–12.
35. Sjolie AK, Porta M, Parving HH et al. The Diabetic REtinopathy Candersantan Trials (DIRECT) Programme: baseline characteristics. JRAAS 2005; 6 (1): 25–32.
36. Suzuki T, Nozawa T, Fujii N et al. Combination therapy of candesartan with statin inhibits progression of atherosclerosis more than statin alone in patients with coronary artery disease. Coron Artery Dis 2011; 22: 352–35.
37. Schrader J, Lüders S, Kulschewski A et al. Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group. The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors. Stroke 2003; 34: 1699–703.
38. Effektivnost' priema blokatora retseptorov angiotenzina II kandesartana v ostroi faze insul'ta: rezul'taty randomizirovannogo issledovaniia SCAST (Scandinavian Candesartan Acute Stroke Trial). Dokazatel'naia kardiologiia. 2011; 2: 17–25. [in Russian]

А.Г.Евдокимова*, М.В.Ложкина, Е.В.Коваленко

ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1
*Aevdokimova@rambler.ru

________________________________________________

A.G.Evdokimova*, M.V.Lozhkina, E.V.Kovalenko

A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*Aevdokimova@rambler.ru