Бронхообструктивный синдром у больных с гастроэзофагеальной рефлюксной болезнью: внепищеводное проявление заболевания или бронхиальная астма?

1. Барламов П.Н. Гастроэзофагеальный рефлюкс при бронхиальной астме. Пульмонология. 2003; 2: 90–3. / Barlamov P.N. Gastroezofageal'nyi refliuks pri bronkhial'noi astme. Pul'monologiia. 2003; 2: 90–3. [in Russian]
2. Бейтуганова И.М., Чучалин А.Г. Рефлюкс-индуцированная бронхиальная астма. Рус. мед. журн. 1998; 17 (6): 1102–8. / Beituganova I.M., Chuchalin A.G. Refliuks-indutsirovannaia bronkhial'naia astma. Rus. med. zhurn. 1998; 17 (6): 1102–8. [in Russian]
3. Ивашкин В.Т., Трухманов А.С. Современный подход к терапии гастроэзофагеальной рефлюксной болезни во врачебной практике. Рус. мед. журн. Болезни органов пищеварения. 2003; 5: 2. / Ivashkin V.T., Trukhmanov A.S. Sovremennyi podkhod k terapii gastroezofageal'noi refliuksnoi bolezni vo vrachebnoi praktike. Rus. med. zhurn. Bolezni organov pishchevareniia. 2003; 5: 2. [in Russian]
4. Корабельников Д.И., Чучалин А.Г. Бронхиальная астма и сопутствующие заболевания органов пищеварения. Пульмонология. 2002; 5: 87–92. / Korabel'nikov D.I., Chuchalin A.G. Bronkhial'naia astma i soputstvuiushchie zabolevaniia organov pishchevareniia. Pul'monologiia. 2002; 5: 87–92. [in Russian]
5. Маев И.В., Юренев Г.Л., Бурков С.Г. и др. Внепищеводные проявления гастроэзофагеальной рефлюксной болезни. Тер. архив. 2007; 3: 57–66. / Maev I.V., Iurenev G.L., Burkov S.G. i dr. Vnepishchevodnye proiavleniia gastroezofageal'noi refliuksnoi bolezni. Ter. arkhiv. 2007; 3: 57–66. [in Russian]
6. Маев И.В., Юренев Г.Л., Бурков С.Г., Сергеева Т.А. Бронхолегочные и орофарингеальные проявления гастроэзофагеальной рефлюксной болезни. Consilium Medicum. Гастроэнтерология. (Прил.). 2006; 2: 22–7. / Maev I.V., Iurenev G.L., Burkov S.G., Sergeeva T.A. Bronkholegochnye i orofaringeal'nye proiavleniia gastroezofageal'noi refliuksnoi bolezni. Consilum Medicum. Gastroenterology. (Suppl.). 2006; 2: 22–7. [in Russian]
7. Плешко Р.И., Суходоло И.В., Огородова Л.М. и др. Морфофункциональные аспекты сопряженности бронхиальной астмы и гастроэзофагеального рефлюкса. Бюл. сиб. медицины. 2005; 4: 54–9. / Pleshko R.I., Sukhodolo I.V., Ogorodova L.M. i dr. Morfofunktsional'nye aspekty sopriazhennosti bronkhial'noi astmy i gastroezofageal'nogo refliuksa. Biul. sib. meditsiny. 2005; 4: 54–9. [in Russian]
8. Шмелев Е.И., Медведев А.В. Клиника и лечение бронхиальной астмы, сочетающейся с гастроэзофагеальным рефлюксом. Пульмонология. 1999; 1: 96–9. / Shmelev E.I., Medvedev A.V. Klinika i lechenie bronkhial'noi astmy, sochetaiushcheisia s gastroezofageal'nym refliuksom. Pul'monologiia. 1999; 1: 96–9. [in Russian]
9. Эрдес С.И., Новикова А.В. Принципы лечения гастродуоденальных заболеваний пищеварительного тракта у детей с бронхиальной астмой. Педиатр. фармакология. 2003; 4 (1): 8–13. / Erdes S.I., Novikova A.V. Printsipy lecheniia gastroduodenal'nykh zabolevanii pishchevaritel'nogo trakta u detei s bronkhial'noi astmoi. Pediatr. farmakologiia. 2003; 4 (1): 8–13. [in Russian]
10. Carmona-Sanchez R, Valdovinos-Diaz MA, Facha MT et al. Hiatal hernia in asthmatic patients: prevalence and its association with gastroesophageal reflux. Rev Invest Clin 1999; 51 (4): 215–20.
11. Cheung TK, Lam B, Lam KF et al. Gastroesophaggeal reflux disease is associated with poor asthma control, quality of life and psychological status in chinese asthma patients. Chest 2009; 135 (5): 1181–5.
12. Crowell MD, Zayat EN, Lacy BE et al. The effects of an inhaled b2-adrenergic agonist on lower esophageal function – a dose-response study. Chest 2001; 120 (4): 1184–9.
13. Di Marino AJJr, Cohen S. Effects of an oral b2-adrenergic agonist on lower esophageal sphincter pressure in normals and in patients with achalasia. Dig Dis Sci 1982; 27 (12): 1063–6.
14. Ekstrom T, Tibbling L. Gastroesophageal reflux and triggering of bronchial asthma: a negative report. Eur J Resp Dis 1987; 71 (3): 177–80.
15. Ekstrom T, Tibbling L. Influence of theophylline on gastroesophageal reflux and asthma. Eur J Clin Pharmacol 1988; 35 (4): 353–6.
16. El-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology 1997; 113: 755–60.
17. Field SK, Evans JA, Price LM. The effect of acid perfusion of the esophagus on ventilation and respiratory sensation. Am J Respir Crit Care Med 1998; 157 (4) [Pt. 1]: 1058–62.
18. Field SK, Underwood M. Prevalence of gastroesophageal reflux symptoms in asthma. Chest 1996; 109 (2): 316–22.
19. Gatto G, Peri V, Cuttitta G. Gastroesophageal reflux symptoms and asthma severity. 7th United European Gastroenterology Week, Roma, Italy. (Abstract P0028) 1999.
20. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma  2011.
21. Harding SM. GERD and airway disease. In: Stein MR. Gastroesophageal Reflux Disease. Lung Biology in Health Disease. New York: Marcel Dekker 1999; p. 139–71.
22. Harding SM, Guzzo MR, Richter JE. 24-h esophageal pH testing in asthmatics: respiratory symptom correlation with esophageal acid events. Chest 1999; 115 (3): 654–9.
23. Harding SM, Richter JE, Guzzo MR. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med 1996; 100 (4): 395–405.
24. Hisel TM, Bielefeldt K, Joss JD. Asthma and gastroesophageal reflux. J Am Osteopath Assooc 1999; 99 (10) [Suppl, Pt 1]: s9–s13.
25. Irwin RS, Curley FJ, French CL. Difficult-to-control asthma: contributing factors and outcome of a systematic management protocol. Chest 1993; 103 (6): 1662–9.
26. Jack CI, Calverley PM, Donnelly RJ et al. Simultaneous tracheal and esophageal pH measurements in asthmatics patients with gastroesophageal reflux. Thorax 1995; 50 (2): 201–4.
27. Kammer P, Dahlke J. Patient acceptability of prolonged pH testing. Gastroenter 2001; 120: A427.
28. Kjellen G, Tibbling L. Effect of conservative treatment of oesophageal dysfunction on bronchial asthma. Eur J Resp Dis 1981; 62 (3): 190–7.
29. Larrain A, Carrasco E. Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. Chest 1991; 99 (6): 1330–5.
30. Lodi U, Harding SM, Coghlan HC. Autonomic regulation in asthmatics with gastroesophageal reflux. Chest 1997; 111 (1): 65–70.
31. Mansfield LE, Stein MR. Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy 1978; 41 (4): 224–6.
32. Mays EE. Intrinsic asthma in adults, association with gastroesophageal reflux. JAMA 1976; 236: 2626–8.
33. Mendelsohn CL. The aspiration of stomach contents into the lungs during obstetric anesthesia. Am J Obstet Gynecol 1946; 52 (2): 191–5.
34. Mittal RK, Balaban DH. The esophagogastric junction. N Engl J Med 1997; 336: 924–32.
35. Patterson RN, Johnston BT, MacMahon J. Oesophageal pH monitoring is of limited value in the diagnosis of «reflux-cough» Eur Respire J 2002; 24 (5): 724–7.
36. Richter JE. Asthma and gastroesophageal reflux disease. The truth is difficult to define. Chest. – 2002; 116: 1150–2.
37. Rodriguez SO, Suarez JR, Morales SO et al. Gastroesophageal reflux and allergic bronchial asthma. Controlled study. Rev Alerg Mex 1999; 46 (2): 38–40.
38. Ruhl CE, Everhart JE. Respiratory complications of gastroesophageal reflux disease (GERD) in a prospective population-based study. Gastroenterology 1999; 115: A92.
39. Singh K, Nain CK, Shrma BC. Silent gastroesophageal reflux in patients with bronchial asthma. J Assoc Physicians India 1998; 46 (2): 179–81.
40. Smith JA. Gastroenterology Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms. 2010; 139: 754–62.
41. Sontag SJ, Harding SM. Gastroesophageal reflux and asthma. In: Goyal and Shaker's GI Motility Online. New York: Nature Publishing Group, 2006; doi:10.1038/gimo47
42. Sontag SJ, O’Connell S, Khandelwal S. Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies. Am J Gastroenter 2003; 98 (5): 987–99.
43. Sontag SJ, O’Connell S, Khandelwal S, Miller T. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology 1990; 99 (3): 613–20.
44. Sontag SJ, O'Connell SA, Miller T et al. Asthmatics have more nocturnal gasping and reflux symptoms than non-asthmatics, and they are related to night-time eating. Am J Gastroenterol 2004; p. 789–96.
45. Sontag SJ, Schnell TG, Miller TQ et al. Prevalence of oesophagiatis in asthmatics. Gut 1992; 33 (7): 872–6.
46. The American Lung Association Asthma Clinical Research Centers. Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma. N Engl J Med 2009; 360: 1487–99.
47. Tuchman DN, Boyle JT, Pack AI et al. Comparison of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology 1984; 87 (4): 872–81.
48. Vakil N, van Zanten SV, Kahrilas P et al. The Montreal Definition and Classification of Gastroesophageal Reflux Disease (GERD): a Global Evidence-Based Consensus. Am J Gastroenterol 2006; 101 (8): 1900–20.
49. Vincent D, Cohen-Jonathan AM, Leront J et al. Gastro-esophageal reflux prevalence and relationship with bronchial reactivity in asthma. Eur Respir J 1997; 10 (10): 2255–9.
50. Zerbib F, Guisset O. Bronchial obstruction in asthma increases esophageal sphincter relax. Am J Respit Crit Care Med 2002; 166: 1206–11.

________________________________________________

1. Barlamov P.N. Gastroezofageal'nyi refliuks pri bronkhial'noi astme. Pul'monologiia. 2003; 2: 90–3. [in Russian]
2. Beituganova I.M., Chuchalin A.G. Refliuks-indutsirovannaia bronkhial'naia astma. Rus. med. zhurn. 1998; 17 (6): 1102–8. [in Russian]
3. Ivashkin V.T., Trukhmanov A.S. Sovremennyi podkhod k terapii gastroezofageal'noi refliuksnoi bolezni vo vrachebnoi praktike. Rus. med. zhurn. Bolezni organov pishchevareniia. 2003; 5: 2. [in Russian]
4. Korabel'nikov D.I., Chuchalin A.G. Bronkhial'naia astma i soputstvuiushchie zabolevaniia organov pishchevareniia. Pul'monologiia. 2002; 5: 87–92. [in Russian]
5. Maev I.V., Iurenev G.L., Burkov S.G. i dr. Vnepishchevodnye proiavleniia gastroezofageal'noi refliuksnoi bolezni. Ter. arkhiv. 2007; 3: 57–66. [in Russian]
6. Maev I.V., Iurenev G.L., Burkov S.G., Sergeeva T.A. Bronkholegochnye i orofaringeal'nye proiavleniia gastroezofageal'noi refliuksnoi bolezni. Consilum Medicum. Gastroenterology. (Suppl.). 2006; 2: 22–7. [in Russian]
7. Pleshko R.I., Sukhodolo I.V., Ogorodova L.M. i dr. Morfofunktsional'nye aspekty sopriazhennosti bronkhial'noi astmy i gastroezofageal'nogo refliuksa. Biul. sib. meditsiny. 2005; 4: 54–9. [in Russian]
8. Shmelev E.I., Medvedev A.V. Klinika i lechenie bronkhial'noi astmy, sochetaiushcheisia s gastroezofageal'nym refliuksom. Pul'monologiia. 1999; 1: 96–9. [in Russian]
9. Erdes S.I., Novikova A.V. Printsipy lecheniia gastroduodenal'nykh zabolevanii pishchevaritel'nogo trakta u detei s bronkhial'noi astmoi. Pediatr. farmakologiia. 2003; 4 (1): 8–13. [in Russian]
10. Carmona-Sanchez R, Valdovinos-Diaz MA, Facha MT et al. Hiatal hernia in asthmatic patients: prevalence and its association with gastroesophageal reflux. Rev Invest Clin 1999; 51 (4): 215–20.
11. Cheung TK, Lam B, Lam KF et al. Gastroesophaggeal reflux disease is associated with poor asthma control, quality of life and psychological status in chinese asthma patients. Chest 2009; 135 (5): 1181–5.
12. Crowell MD, Zayat EN, Lacy BE et al. The effects of an inhaled b2-adrenergic agonist on lower esophageal function – a dose-response study. Chest 2001; 120 (4): 1184–9.
13. Di Marino AJJr, Cohen S. Effects of an oral b2-adrenergic agonist on lower esophageal sphincter pressure in normals and in patients with achalasia. Dig Dis Sci 1982; 27 (12): 1063–6.
14. Ekstrom T, Tibbling L. Gastroesophageal reflux and triggering of bronchial asthma: a negative report. Eur J Resp Dis 1987; 71 (3): 177–80.
15. Ekstrom T, Tibbling L. Influence of theophylline on gastroesophageal reflux and asthma. Eur J Clin Pharmacol 1988; 35 (4): 353–6.
16. El-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology 1997; 113: 755–60.
17. Field SK, Evans JA, Price LM. The effect of acid perfusion of the esophagus on ventilation and respiratory sensation. Am J Respir Crit Care Med 1998; 157 (4) [Pt. 1]: 1058–62.
18. Field SK, Underwood M. Prevalence of gastroesophageal reflux symptoms in asthma. Chest 1996; 109 (2): 316–22.
19. Gatto G, Peri V, Cuttitta G. Gastroesophageal reflux symptoms and asthma severity. 7th United European Gastroenterology Week, Roma, Italy. (Abstract P0028) 1999.
20. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma  2011.
21. Harding SM. GERD and airway disease. In: Stein MR. Gastroesophageal Reflux Disease. Lung Biology in Health Disease. New York: Marcel Dekker 1999; p. 139–71.
22. Harding SM, Guzzo MR, Richter JE. 24-h esophageal pH testing in asthmatics: respiratory symptom correlation with esophageal acid events. Chest 1999; 115 (3): 654–9.
23. Harding SM, Richter JE, Guzzo MR. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med 1996; 100 (4): 395–405.
24. Hisel TM, Bielefeldt K, Joss JD. Asthma and gastroesophageal reflux. J Am Osteopath Assooc 1999; 99 (10) [Suppl, Pt 1]: s9–s13.
25. Irwin RS, Curley FJ, French CL. Difficult-to-control asthma: contributing factors and outcome of a systematic management protocol. Chest 1993; 103 (6): 1662–9.
26. Jack CI, Calverley PM, Donnelly RJ et al. Simultaneous tracheal and esophageal pH measurements in asthmatics patients with gastroesophageal reflux. Thorax 1995; 50 (2): 201–4.
27. Kammer P, Dahlke J. Patient acceptability of prolonged pH testing. Gastroenter 2001; 120: A427.
28. Kjellen G, Tibbling L. Effect of conservative treatment of oesophageal dysfunction on bronchial asthma. Eur J Resp Dis 1981; 62 (3): 190–7.
29. Larrain A, Carrasco E. Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. Chest 1991; 99 (6): 1330–5.
30. Lodi U, Harding SM, Coghlan HC. Autonomic regulation in asthmatics with gastroesophageal reflux. Chest 1997; 111 (1): 65–70.
31. Mansfield LE, Stein MR. Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy 1978; 41 (4): 224–6.
32. Mays EE. Intrinsic asthma in adults, association with gastroesophageal reflux. JAMA 1976; 236: 2626–8.
33. Mendelsohn CL. The aspiration of stomach contents into the lungs during obstetric anesthesia. Am J Obstet Gynecol 1946; 52 (2): 191–5.
34. Mittal RK, Balaban DH. The esophagogastric junction. N Engl J Med 1997; 336: 924–32.
35. Patterson RN, Johnston BT, MacMahon J. Oesophageal pH monitoring is of limited value in the diagnosis of «reflux-cough» Eur Respire J 2002; 24 (5): 724–7.
36. Richter JE. Asthma and gastroesophageal reflux disease. The truth is difficult to define. Chest. – 2002; 116: 1150–2.
37. Rodriguez SO, Suarez JR, Morales SO et al. Gastroesophageal reflux and allergic bronchial asthma. Controlled study. Rev Alerg Mex 1999; 46 (2): 38–40.
38. Ruhl CE, Everhart JE. Respiratory complications of gastroesophageal reflux disease (GERD) in a prospective population-based study. Gastroenterology 1999; 115: A92.
39. Singh K, Nain CK, Shrma BC. Silent gastroesophageal reflux in patients with bronchial asthma. J Assoc Physicians India 1998; 46 (2): 179–81.
40. Smith JA. Gastroenterology Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms. 2010; 139: 754–62.
41. Sontag SJ, Harding SM. Gastroesophageal reflux and asthma. In: Goyal and Shaker's GI Motility Online. New York: Nature Publishing Group, 2006; doi:10.1038/gimo47
42. Sontag SJ, O’Connell S, Khandelwal S. Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies. Am J Gastroenter 2003; 98 (5): 987–99.
43. Sontag SJ, O’Connell S, Khandelwal S, Miller T. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology 1990; 99 (3): 613–20.
44. Sontag SJ, O'Connell SA, Miller T et al. Asthmatics have more nocturnal gasping and reflux symptoms than non-asthmatics, and they are related to night-time eating. Am J Gastroenterol 2004; p. 789–96.
45. Sontag SJ, Schnell TG, Miller TQ et al. Prevalence of oesophagiatis in asthmatics. Gut 1992; 33 (7): 872–6.
46. The American Lung Association Asthma Clinical Research Centers. Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma. N Engl J Med 2009; 360: 1487–99.
47. Tuchman DN, Boyle JT, Pack AI et al. Comparison of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology 1984; 87 (4): 872–81.
48. Vakil N, van Zanten SV, Kahrilas P et al. The Montreal Definition and Classification of Gastroesophageal Reflux Disease (GERD): a Global Evidence-Based Consensus. Am J Gastroenterol 2006; 101 (8): 1900–20.
49. Vincent D, Cohen-Jonathan AM, Leront J et al. Gastro-esophageal reflux prevalence and relationship with bronchial reactivity in asthma. Eur Respir J 1997; 10 (10): 2255–9.
50. Zerbib F, Guisset O. Bronchial obstruction in asthma increases esophageal sphincter relax. Am J Respit Crit Care Med 2002; 166: 1206–11.

Г.Л.Юренев*, А.А.Самсонов, Т.В.Юренева-Тхоржевская, И.В.Маев

ФГБОУ ВО  Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1 
*yurenev@list.ru

________________________________________________

G.L.Yurenev*, A.A.Samsonov, T.V.Yureneva-Tkhorzhevskaya, I.V.Maev

A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*yurenev@list.ru