Терапия послеоперационной боли у взрослых (по материалам заседания Совета экспертов)

1. Chou R, Gordon DB, de Leon-Casasola OA et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016; 17 (2): 131–57. DOI: http://dx.doi.org/10.1016/j.jpain.2015.12.008
2. Овечкин А.М., Свиридов С.В. Послеоперационная боль и обезболивание: современное состояние проблемы. Медицина неотложных состояний. 2011; 6 (37): 23. / Ovechkin A.M., Sviridov S.V. Posleoperatsionnaya bol' i obezbolivanie: sovremennoe sostoyanie problemy. Meditsina neotlozhnykh sostoyaniy. 2011; 6 (37): 23. [in Russian]
3. Dolin S, Cashman J, Bland J. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth 2002; 89: 409–23.
4. Gan TJ, Habib AS, Miller TE et al. Incidence, patient satisfaction, and perceptions of postsurgical pain: Results from a US national survey. Curr Med Res Opin 2014; 30: 149–60.
5. Rodgers A, Walker N, Schug S. Reduction of postoperative mortality and morbidity with epidural or spinal anesthesia: results from overview of randomized trials. BMJ 2000; 321: 1–12.
6. Koneti КК, Jones М. Management of acute pain. Surgery February 2016; 34 (2): 84–90. DOI: http://dx.doi.org/10.1016/j.mpsur.2015.11.008
7. Chapman JLR, Lalkhen AG. Postoperative analgesia. Anaesth Intensive Care Med 2016; 17 (3): 144–50. DOI: http://dx.doi.org/10.1016/j.mpaic.2016.01.001
8. Rawal N. Current issues in postoperative pain management. Eur J Anaesthesiol 2016; 33 (3): 160–71. DOI: 10.1097/EJA.0000000000000366
9. Benhamou D, Berti M, Brodner G et al. Postoperative Analgesic THerapy Observational Survey (PATHOS): a practice pattern study in 7 Central/Southern European countries. Pain 2008; 136 (1–2): 134–41. DOI: 10.1016/j.pain.2007.06.028
10. Федеральный закон от 21.11.2011 №323-ФЗ «Об основах охраны здоровья граждан в Российской Федерации». http://www.consultant.ru/document/ cons_doc_LAW_121895/ / Federal'nyy zakon ot 21.11.2011 №323-FZ "Ob osnovakh okhrany zdorov'ya grazhdan v Rossiyskoy Federatsii". http://www.consultant.ru/document/cons_doc_LAW_121895/ [in Russian]
11. Kehlet H, Dahl JB. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg 1993; 77 (5): 1048–56.
12. Ladha KS, Patorno E, Huybrechts KF et al. Variations in the Use of Perioperative Multimodal Analgesic Therapy. Anesthesiology 2016; 124 (4): 837–45. DOI: 10.1097/ALN.0000000000001034
13. Gordon DB, de Leon-Casasola OA, Wu CL et al. Research Gaps in Practice Guidelines for Acute Postoperative Pain Management in Adults: Findings From a Review of the Evidence for an American Pain Society Clinical Practice Guideline. J Pain 2016; 17 (2): 158–66. DOI: http://dx.doi.org/10.1016/j.jpain.2015.10.023
14. Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth 2001; 87: 62–72.
15. Park WY, Thompson JS, Lee KK. Effect of epidural anesthesia and analgesia on perioperative outcome: a randomized, controlled Veterans Affairs cooperative study. Ann Surg 2001; 234: 560–9.
16. Осипова Н.А. Послеоперационное обезболивание в России: клинические и организационные аспекты. Общая реаниматология. 2013; 9 (4): 5. / Osipova N.A. Posleoperatsionnoe obezbolivanie v Rossii: klinicheskie i organizatsionnye aspekty. Obshchaya reanimatologiya. 2013; 9 (4): 5. [in Russian]
17. Watkins EA, Phil D, Wollan PC et al. A Population in Pain: Report from the Olmsted County Health Study. J Pain Medicine 2008; 9.
18. Pruss TP et al. Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam. Postgrad Med J 1990; 66 (Suppl. 4): S18–21.
19. Radhofer-Welte S et al. Comparative bioavailability of lornoxicam as single doses of quick-release tablet, standard tablet and intramuscular injection: a randomized, open-label, crossover phase I study in healthy volunteers. Clin Drug Investig 2008; 28 (6): 345–51.
20. Hitzenberger G et al. Pharmacokinetics of lornoxicam in man. Postgrad Med J 1990; 66 (Suppl. 4): S22–7.
21. Skjodt NM, Davies NM. Clinical pharmacokinetics of lornoxicam. A short half-life oxicam. Clin Pharmacokinet 1998; 34 (6): 421–8.
22. Ankier SI et al. Chlortenoxicam pharmacokinetics in young and elderly human volunteers. Postgrad Med J 1988; 64 (756): 752–4.
23. Hillstrom С, Jan G, Jakobsson JG. Lornoxicam: pharmacology and usefulness to treat acute postoperative and musculoskeletal pain a narrative review. Expert Opin Pharmacother 2013; 14 (11): 1–16.
24. Ilias W, Jansen M. Pain control after hysterectomy: an observer-blind, randomized trial of lornoxicam versus tramadol. Br J Clin Pract 1996; 50: 197–202.
25. Mowafi HA, Elmakarim EA, Ismail S et al. Intravenous lornoxicam is more effective than paracetamol as a supplemental analgesic after lower abdominal surgery: a randomized controlled trial. World J Surg 2012; 36: 2039–44.
26. Karaman S, Gunusen I, Uyar M, Firat V. The effect of pre-operative lornoxicam and ketoprofen application on the morphine consumption of post-operative patient-controlled analgesia. J Int Med Res 2006; 34: 168–75.
27. Erdoğan I, Cakan T, Ozcan A et al. Effect of lornoxicam on postoperative analgesia after myomectomy. Agri 2008; 20: 26–31.
28. Zhao H, Ye TH, Gong ZY. Non-inferiority study of lornoxicam to patient-controlled analgesia in patients after hysterectomy]. Beijing Ds Xue Xue Bao 2013; 45: 119–22.
29. Papadima A, Lagoudianakis EE, Antonakis PT et al. Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial. Eur J Anaesthesiol 2007; 24: 154–8.
30. Mentes O, Bagci M. Postoperative pain management after inguinal hernia repair: lornoxicam versus tramadol. Hernia 2009; 13: 427–30.
31. Kouroukli I, Zompolas V, Tsekoura V et al. Comparison between lornoxicam quick-release and parecoxib for post-operative analgesia after laparoscopic cholecystectomy: A prospective randomized, placebo-controlled trial. J Anaesthesiol Clin Pharmacol 2013; 29: 485–90.
32. Staunstrup H, Ovesen J, Larsen UT et al. Efficacy and tolerability of lornoxicam versus tramadol in postoperative pain. J Clin Pharmacol 1999; 39: 834–41.
33. Rosenow DE, Albrechtsen M, Stolke D. A comparison of patient-controlled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery. Anesth Analg 1998; 86: 1045–50.
34. Arslan M, Ciçek R, Celep B et al. Comparison of the analgesic effects of intravenous paracetamol and lornoxicam in postoperative pain following thyroidectomies. Agri 2011; 23: 160–6.
35. Das SK, Banerjee M, Mondal S et al. A comparative study of efficacy and safety of lornoxicam versus tramadol as analgesics after surgery on head and neck. Indian J Otolaryngol Head Neck Surg 2013; 65 (Suppl. 1): 126–30.
36. Sener M, Yilmazer C, Yilmaz I et al. Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone. J Clin Anesth 2008; 20: 103–8.
37. Abdelhalim AA, Al Harethy S, Moustafa M. Lornoxicam versus tramadol for post-operative pain relief in patients undergoing ENT procedures. Saudi J Anaesth 2014; 8: 38–44.

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1. Chou R, Gordon DB, de Leon-Casasola OA et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016; 17 (2): 131–57. DOI: http://dx.doi.org/10.1016/j.jpain.2015.12.008
2. Ovechkin A.M., Sviridov S.V. Posleoperatsionnaya bol' i obezbolivanie: sovremennoe sostoyanie problemy. Meditsina neotlozhnykh sostoyaniy. 2011; 6 (37): 23. [in Russian]
3. Dolin S, Cashman J, Bland J. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth 2002; 89: 409–23.
4. Gan TJ, Habib AS, Miller TE et al. Incidence, patient satisfaction, and perceptions of postsurgical pain: Results from a US national survey. Curr Med Res Opin 2014; 30: 149–60.
5. Rodgers A, Walker N, Schug S. Reduction of postoperative mortality and morbidity with epidural or spinal anesthesia: results from overview of randomized trials. BMJ 2000; 321: 1–12.
6. Koneti КК, Jones М. Management of acute pain. Surgery February 2016; 34 (2): 84–90. DOI: http://dx.doi.org/10.1016/j.mpsur.2015.11.008
7. Chapman JLR, Lalkhen AG. Postoperative analgesia. Anaesth Intensive Care Med 2016; 17 (3): 144–50. DOI: http://dx.doi.org/10.1016/j.mpaic.2016.01.001
8. Rawal N. Current issues in postoperative pain management. Eur J Anaesthesiol 2016; 33 (3): 160–71. DOI: 10.1097/EJA.0000000000000366
9. Benhamou D, Berti M, Brodner G et al. Postoperative Analgesic THerapy Observational Survey (PATHOS): a practice pattern study in 7 Central/Southern European countries. Pain 2008; 136 (1–2): 134–41. DOI: 10.1016/j.pain.2007.06.028
10. Federal'nyy zakon ot 21.11.2011 №323-FZ "Ob osnovakh okhrany zdorov'ya grazhdan v Rossiyskoy Federatsii". http://www.consultant.ru/document/cons_doc_LAW_121895/ [in Russian]
11. Kehlet H, Dahl JB. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg 1993; 77 (5): 1048–56.
12. Ladha KS, Patorno E, Huybrechts KF et al. Variations in the Use of Perioperative Multimodal Analgesic Therapy. Anesthesiology 2016; 124 (4): 837–45. DOI: 10.1097/ALN.0000000000001034
13. Gordon DB, de Leon-Casasola OA, Wu CL et al. Research Gaps in Practice Guidelines for Acute Postoperative Pain Management in Adults: Findings From a Review of the Evidence for an American Pain Society Clinical Practice Guideline. J Pain 2016; 17 (2): 158–66. DOI: http://dx.doi.org/10.1016/j.jpain.2015.10.023
14. Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth 2001; 87: 62–72.
15. Park WY, Thompson JS, Lee KK. Effect of epidural anesthesia and analgesia on perioperative outcome: a randomized, controlled Veterans Affairs cooperative study. Ann Surg 2001; 234: 560–9.
16. Osipova N.A. Posleoperatsionnoe obezbolivanie v Rossii: klinicheskie i organizatsionnye aspekty. Obshchaya reanimatologiya. 2013; 9 (4): 5. [in Russian]
17. Watkins EA, Phil D, Wollan PC et al. A Population in Pain: Report from the Olmsted County Health Study. J Pain Medicine 2008; 9.
18. Pruss TP et al. Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam. Postgrad Med J 1990; 66 (Suppl. 4): S18–21.
19. Radhofer-Welte S et al. Comparative bioavailability of lornoxicam as single doses of quick-release tablet, standard tablet and intramuscular injection: a randomized, open-label, crossover phase I study in healthy volunteers. Clin Drug Investig 2008; 28 (6): 345–51.
20. Hitzenberger G et al. Pharmacokinetics of lornoxicam in man. Postgrad Med J 1990; 66 (Suppl. 4): S22–7.
21. Skjodt NM, Davies NM. Clinical pharmacokinetics of lornoxicam. A short half-life oxicam. Clin Pharmacokinet 1998; 34 (6): 421–8.
22. Ankier SI et al. Chlortenoxicam pharmacokinetics in young and elderly human volunteers. Postgrad Med J 1988; 64 (756): 752–4.
23. Hillstrom С, Jan G, Jakobsson JG. Lornoxicam: pharmacology and usefulness to treat acute postoperative and musculoskeletal pain a narrative review. Expert Opin Pharmacother 2013; 14 (11): 1–16.
24. Ilias W, Jansen M. Pain control after hysterectomy: an observer-blind, randomized trial of lornoxicam versus tramadol. Br J Clin Pract 1996; 50: 197–202.
25. Mowafi HA, Elmakarim EA, Ismail S et al. Intravenous lornoxicam is more effective than paracetamol as a supplemental analgesic after lower abdominal surgery: a randomized controlled trial. World J Surg 2012; 36: 2039–44.
26. Karaman S, Gunusen I, Uyar M, Firat V. The effect of pre-operative lornoxicam and ketoprofen application on the morphine consumption of post-operative patient-controlled analgesia. J Int Med Res 2006; 34: 168–75.
27. Erdoğan I, Cakan T, Ozcan A et al. Effect of lornoxicam on postoperative analgesia after myomectomy. Agri 2008; 20: 26–31.
28. Zhao H, Ye TH, Gong ZY. Non-inferiority study of lornoxicam to patient-controlled analgesia in patients after hysterectomy]. Beijing Ds Xue Xue Bao 2013; 45: 119–22.
29. Papadima A, Lagoudianakis EE, Antonakis PT et al. Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial. Eur J Anaesthesiol 2007; 24: 154–8.
30. Mentes O, Bagci M. Postoperative pain management after inguinal hernia repair: lornoxicam versus tramadol. Hernia 2009; 13: 427–30.
31. Kouroukli I, Zompolas V, Tsekoura V et al. Comparison between lornoxicam quick-release and parecoxib for post-operative analgesia after laparoscopic cholecystectomy: A prospective randomized, placebo-controlled trial. J Anaesthesiol Clin Pharmacol 2013; 29: 485–90.
32. Staunstrup H, Ovesen J, Larsen UT et al. Efficacy and tolerability of lornoxicam versus tramadol in postoperative pain. J Clin Pharmacol 1999; 39: 834–41.
33. Rosenow DE, Albrechtsen M, Stolke D. A comparison of patient-controlled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery. Anesth Analg 1998; 86: 1045–50.
34. Arslan M, Ciçek R, Celep B et al. Comparison of the analgesic effects of intravenous paracetamol and lornoxicam in postoperative pain following thyroidectomies. Agri 2011; 23: 160–6.
35. Das SK, Banerjee M, Mondal S et al. A comparative study of efficacy and safety of lornoxicam versus tramadol as analgesics after surgery on head and neck. Indian J Otolaryngol Head Neck Surg 2013; 65 (Suppl. 1): 126–30.
36. Sener M, Yilmazer C, Yilmaz I et al. Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone. J Clin Anesth 2008; 20: 103–8.
37. Abdelhalim AA, Al Harethy S, Moustafa M. Lornoxicam versus tramadol for post-operative pain relief in patients undergoing ENT procedures. Saudi J Anaesth 2014; 8: 38–44.