Идиопатические интерстициальные пневмонии: фокус на классификацию, патологию и диагностику
Идиопатические интерстициальные пневмонии: фокус на классификацию, патологию и диагностику
Юдин А.А., Татаринова В.К. Идиопатические интерстициальные пневмонии: фокус на классификацию, патологию и диагностику. Consilium Medicum. Болезни органов дыхания (Прил.). 2016; с. 57–70.
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Yudin A.A., Tatarinova V.K. Idiopathic interstitial pneumonia: focus of classification, pathology and diagnosis. Consilium Medicum. Respiratory Organs Diseases (Suppl.). 2016; p. 57–70.
Идиопатические интерстициальные пневмонии: фокус на классификацию, патологию и диагностику
Юдин А.А., Татаринова В.К. Идиопатические интерстициальные пневмонии: фокус на классификацию, патологию и диагностику. Consilium Medicum. Болезни органов дыхания (Прил.). 2016; с. 57–70.
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Yudin A.A., Tatarinova V.K. Idiopathic interstitial pneumonia: focus of classification, pathology and diagnosis. Consilium Medicum. Respiratory Organs Diseases (Suppl.). 2016; p. 57–70.
Идиопатические интерстициальные пневмонии (ИИП) – группа заболеваний легких с неизвестной этиологией, которая входит в группу интерстициальных заболеваний легких. Они характеризуются увеличением интерстициального пространства – части паренхимы легких, расположенной между эпителиальной и эндотелиальной базальной мембраной и имеющей разной степени выраженности инфильтраты из клеток воспаления и фиброзных кластеров, в которых находятся пролиферирующие фибробласты и формируется патологический коллагеновый матрикс. В настоящий момент нет понимания механизмов, которые приводят к формированию отдельных клинических единиц ИИП. Фокус клинической диагностики этих заболеваний сводится к сопоставлению междисциплинарных данных: клинических, лабораторных, функциональных, рентгенологических и патоморфологических, умению провести динамическое сопоставление полученных данных. Не всегда точный диагноз заболевания может определить прогноз. В статье представлены различные диагностические особенности ИИП согласно принятой классификации ATS/ERS, 2002, с изменениями 2013 г.
Idiopathic interstitial pneumonia (IIP) is a group of diseases with unknown etiology which belongs to interstitial lung diseases. It is characterized by enlargement of interstitial space – the part of lung parenchyma between epithelial and endothelial basal membrane with different Infiltrates of varying dense, made of inflammatory cells and fibrous clusters. Clusters consist of proliferating fibroblasts which form pathological collagen matrix. Currently there is no understanding of mechanisms, which lead to single cases of IIP. The main idea of diagnosis is the analysis of interdisciplinary data: clinical, laboratory, functional, imaging and morphology. Accurate diagnosis does not always reflect prognosis. Article presents different main diagnostic features of IIP, according to 2002 ATS/ERS classification with updates in 2013.
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Авторы
А.А.Юдин*, В.К.Татаринова
ФГБОУ ВО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*youdine@gmail.com
________________________________________________
A.A.Yudin*, V.K.Tatarinova
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*youdine@gmail.com