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Назальные деконгестанты: возможно ли повысить их безопасность?
Назальные деконгестанты: возможно ли повысить их безопасность?
Поляков Д.П. Назальные деконгестанты: возможно ли повысить их безопасность? Consilium Medicum. Болезни органов дыхания (Прил.). 2016; с. 5–10.
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Аннотация
Назальные деконгестанты – средства с высокой эффективностью в отношении отека слизистой оболочки полости носа любой этиологии. Однако их применение сопряжено с рядом побочных эффектов и нежелательных явлений (цито- и цилиотоксическое действие, системные симпатомиметические эффекты, эффект «рикошета», психологическая зависимость). С целью повышения профиля безопасности препаратов данной фармакологической группы обосновано применение комбинированных средств, включающих a2-адреномиметики и декспантенол. Приведен анализ экспериментальных и клинических исследований данной комбинации лекарственных веществ.
Ключевые слова: назальные деконгестанты, сосудосуживающие препараты, декспантенол, ксилометазолин.
Key words: nasal decongestants, vasoconstrictor drugs, dexpanthenol, xylometazoline.
Ключевые слова: назальные деконгестанты, сосудосуживающие препараты, декспантенол, ксилометазолин.
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Key words: nasal decongestants, vasoconstrictor drugs, dexpanthenol, xylometazoline.
Полный текст
Список литературы
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2. Bénard-Laribière A, Jové J, Lassalle R et al. Drug use in French children: a population-based study. Arch Dis Child 2015 May 14. pii: archdischild-2014-307224
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14. Knipping S, Holzhausen HJ, Riederer A, Bloching M. Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa. HNO 2006; 54 (10): 742–8.
15. Кунельская Н.Л., Царапкин Г.Ю., Артемьев М.Е. и др. Консервативное лечение химического повреждения. Мед. совет. 2013; 3: 63–4. / Kunel'skaia N.L., Tsarapkin G.Iu., Artem'ev M.E. i dr. Konservativnoe lechenie khimicheskogo povrezhdeniia. Med. sovet. 2013; 3: 63–4. [in Russian]
16. Proctor DW, Adams GK. Physiology and pharmacology of nasal function and mucous secretion. Pharmacol Ther Bull 1976; 2: 493–509.
17. Montalban J, Ibanez L, Rodriguez C et al. Cerebral infarction after excessive use of nasal decongestants. J Neurol Neurosurg Psychiatry 1989; 52: 541–43.
18. Wenzel S, Sagowski C, Laux G et al. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83.
19. Калашникова О.В., Челпаченко О.Е. Клинико-лабораторная характеристика отравлений топическими деконгестантами у детей. Вестник ОГУ. 2013; 9 (158): 96–9. / Kalashnikova O.V., Chelpachenko O.E. Kliniko-laboratornaia kharakteristika otravlenii topicheskimi dekongestantami u detei. Vestnik OGU. 2013; 9 (158): 96–9. [in Russian]
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21. Hosemann W, Wigand ME, Göde U et al. Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol 1991; 248 (7): 390–4.
22. Verse T, Klöcker N, Riedel F et al. Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance. HNO 2004; 52 (7): 611–5.
23. Klocker N, Verse T, Rudolph P. The protective effect of dexpanthenol in nasal sprays and ciliary-toxic studies in vitro. Laryngorhinootologie 2003; 82 (3): 177–82.
24. Klocker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effect of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol 2004; 18 (5): 315–20.
25. Kehrl W, Sonnemann U, Dethlefsen U. Advance in therapy of acute rhinitis – comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis. Laryngorhinootologie 2003; 82 (4): 266–71.
26. Jagade Mahan V, Langade Deepak G, Pophale Rupesh R, Prabhu Arun. Oxymetazolyn and dexpanthenol in nasal congestion. Indian J Otolaryngol Head Neck Surg 2008; 60: 393–7.
27. Kehrl W, Sonnemann U. Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior. Laryngorhinootologie 1998; 77 (9): 506–12.
28. Kehrl W, Sonnemann U. Improving wound healing after nose surgery by combined flvinistration of xylometazoline and dexpanthenol. Laryngorhinootologie 2000; 79 (3): 151–4.
29. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic Acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy Volume 2014, Article ID 635490, 10 pages http://dx.doi.org/10.1155/2014/635490
30. Данные компании КРКА. / Dannye kompanii KRKA. [in Russian]
2. Bénard-Laribière A, Jové J, Lassalle R et al. Drug use in French children: a population-based study. Arch Dis Child 2015 May 14. pii: archdischild-2014-307224
3. Lopatin A.S. Nazal'nye dekongestanty: starye preparaty i novye formy. Doktor.ru. 2011; 6 (65): 17–23. [in Russian]
4. Stewart M, Ferguson BJ, Fromer L. Epidemiology and burden of nasal congestion. Int J Gen Med 2010; 3: 37–45.
5. Naclerio RM, Bachert C, Baraniuk JN. Pathophysiology of nasal congestion. Int J Gen Med 2010; 3: 47–57
6. http://glav-otolar/documents
7. Lopatin A.S. Rinit. M.: Literra, 2010. [in Russian]
8. Shaikh N, Wald ER. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev 2014; 10: CD007909
9. Coleman C, Moore M. Decongestants and antihistamines for acute otitis media in children. Cochrane Database Syst Rev 2008; 3: CD001727
10. Griffin G, Flynn CA. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2011; 9: CD003423
11. Hofmann T, Wolf G, Koidl B. In vitro studies of the effect of vasoconstrictor nose drops on ciliary epithelium of human nasal mucosa. Laryngorhinootologie 1995; 74 (9): 564–7.
12. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8.
13. Graf P, Hallen H. Effect on the nasal mucosaof long-term treatment with oxymetasoline, bensalconium chloride, and placebo nasal sprays. Laryngoscope 1996; 106 (5; Pt. 1): 605–9.
14. Knipping S, Holzhausen HJ, Riederer A, Bloching M. Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa. HNO 2006; 54 (10): 742–8.
15. Kunel'skaia N.L., Tsarapkin G.Iu., Artem'ev M.E. i dr. Konservativnoe lechenie khimicheskogo povrezhdeniia. Med. sovet. 2013; 3: 63–4. [in Russian]
16. Proctor DW, Adams GK. Physiology and pharmacology of nasal function and mucous secretion. Pharmacol Ther Bull 1976; 2: 493–509.
17. Montalban J, Ibanez L, Rodriguez C et al. Cerebral infarction after excessive use of nasal decongestants. J Neurol Neurosurg Psychiatry 1989; 52: 541–43.
18. Wenzel S, Sagowski C, Laux G et al. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83.
19. Kalashnikova O.V., Chelpachenko O.E. Kliniko-laboratornaia kharakteristika otravlenii topicheskimi dekongestantami u detei. Vestnik OGU. 2013; 9 (158): 96–9. [in Russian]
20. Hosemann W, Göde U, Länger F, Wigand ME. Experimental studies of wound healing in the paranasal sinuses. II. Spontaneous wound healing and drug effects in a standardized wound model. HNO 1991; 39 (2): 48–54.
21. Hosemann W, Wigand ME, Göde U et al. Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol 1991; 248 (7): 390–4.
22. Verse T, Klöcker N, Riedel F et al. Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance. HNO 2004; 52 (7): 611–5.
23. Klocker N, Verse T, Rudolph P. The protective effect of dexpanthenol in nasal sprays and ciliary-toxic studies in vitro. Laryngorhinootologie 2003; 82 (3): 177–82.
24. Klocker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effect of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol 2004; 18 (5): 315–20.
25. Kehrl W, Sonnemann U, Dethlefsen U. Advance in therapy of acute rhinitis – comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis. Laryngorhinootologie 2003; 82 (4): 266–71.
26. Jagade Mahan V, Langade Deepak G, Pophale Rupesh R, Prabhu Arun. Oxymetazolyn and dexpanthenol in nasal congestion. Indian J Otolaryngol Head Neck Surg 2008; 60: 393–7.
27. Kehrl W, Sonnemann U. Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior. Laryngorhinootologie 1998; 77 (9): 506–12.
28. Kehrl W, Sonnemann U. Improving wound healing after nose surgery by combined flvinistration of xylometazoline and dexpanthenol. Laryngorhinootologie 2000; 79 (3): 151–4.
29. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic Acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy Volume 2014, Article ID 635490, 10 pages http://dx.doi.org/10.1155/2014/635490
30. Dannye kompanii KRKA. [in Russian]
2. Bénard-Laribière A, Jové J, Lassalle R et al. Drug use in French children: a population-based study. Arch Dis Child 2015 May 14. pii: archdischild-2014-307224
3. Лопатин А.С. Назальные деконгестанты: старые препараты и новые формы. Доктор.ру. 2011; 6 (65): 17–23. / Lopatin A.S. Nazal'nye dekongestanty: starye preparaty i novye formy. Doktor.ru. 2011; 6 (65): 17–23. [in Russian]
4. Stewart M, Ferguson BJ, Fromer L. Epidemiology and burden of nasal congestion. Int J Gen Med 2010; 3: 37–45.
5. Naclerio RM, Bachert C, Baraniuk JN. Pathophysiology of nasal congestion. Int J Gen Med 2010; 3: 47–57
6. http://glav-otolar/documents
7. Лопатин А.С. Ринит. М.: Литерра, 2010. / Lopatin A.S. Rinit. M.: Literra, 2010. [in Russian]
8. Shaikh N, Wald ER. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev 2014; 10: CD007909
9. Coleman C, Moore M. Decongestants and antihistamines for acute otitis media in children. Cochrane Database Syst Rev 2008; 3: CD001727
10. Griffin G, Flynn CA. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2011; 9: CD003423
11. Hofmann T, Wolf G, Koidl B. In vitro studies of the effect of vasoconstrictor nose drops on ciliary epithelium of human nasal mucosa. Laryngorhinootologie 1995; 74 (9): 564–7.
12. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8.
13. Graf P, Hallen H. Effect on the nasal mucosaof long-term treatment with oxymetasoline, bensalconium chloride, and placebo nasal sprays. Laryngoscope 1996; 106 (5; Pt. 1): 605–9.
14. Knipping S, Holzhausen HJ, Riederer A, Bloching M. Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa. HNO 2006; 54 (10): 742–8.
15. Кунельская Н.Л., Царапкин Г.Ю., Артемьев М.Е. и др. Консервативное лечение химического повреждения. Мед. совет. 2013; 3: 63–4. / Kunel'skaia N.L., Tsarapkin G.Iu., Artem'ev M.E. i dr. Konservativnoe lechenie khimicheskogo povrezhdeniia. Med. sovet. 2013; 3: 63–4. [in Russian]
16. Proctor DW, Adams GK. Physiology and pharmacology of nasal function and mucous secretion. Pharmacol Ther Bull 1976; 2: 493–509.
17. Montalban J, Ibanez L, Rodriguez C et al. Cerebral infarction after excessive use of nasal decongestants. J Neurol Neurosurg Psychiatry 1989; 52: 541–43.
18. Wenzel S, Sagowski C, Laux G et al. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83.
19. Калашникова О.В., Челпаченко О.Е. Клинико-лабораторная характеристика отравлений топическими деконгестантами у детей. Вестник ОГУ. 2013; 9 (158): 96–9. / Kalashnikova O.V., Chelpachenko O.E. Kliniko-laboratornaia kharakteristika otravlenii topicheskimi dekongestantami u detei. Vestnik OGU. 2013; 9 (158): 96–9. [in Russian]
20. Hosemann W, Göde U, Länger F, Wigand ME. Experimental studies of wound healing in the paranasal sinuses. II. Spontaneous wound healing and drug effects in a standardized wound model. HNO 1991; 39 (2): 48–54.
21. Hosemann W, Wigand ME, Göde U et al. Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol 1991; 248 (7): 390–4.
22. Verse T, Klöcker N, Riedel F et al. Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance. HNO 2004; 52 (7): 611–5.
23. Klocker N, Verse T, Rudolph P. The protective effect of dexpanthenol in nasal sprays and ciliary-toxic studies in vitro. Laryngorhinootologie 2003; 82 (3): 177–82.
24. Klocker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effect of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol 2004; 18 (5): 315–20.
25. Kehrl W, Sonnemann U, Dethlefsen U. Advance in therapy of acute rhinitis – comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis. Laryngorhinootologie 2003; 82 (4): 266–71.
26. Jagade Mahan V, Langade Deepak G, Pophale Rupesh R, Prabhu Arun. Oxymetazolyn and dexpanthenol in nasal congestion. Indian J Otolaryngol Head Neck Surg 2008; 60: 393–7.
27. Kehrl W, Sonnemann U. Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior. Laryngorhinootologie 1998; 77 (9): 506–12.
28. Kehrl W, Sonnemann U. Improving wound healing after nose surgery by combined flvinistration of xylometazoline and dexpanthenol. Laryngorhinootologie 2000; 79 (3): 151–4.
29. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic Acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy Volume 2014, Article ID 635490, 10 pages http://dx.doi.org/10.1155/2014/635490
30. Данные компании КРКА. / Dannye kompanii KRKA. [in Russian]
________________________________________________
2. Bénard-Laribière A, Jové J, Lassalle R et al. Drug use in French children: a population-based study. Arch Dis Child 2015 May 14. pii: archdischild-2014-307224
3. Lopatin A.S. Nazal'nye dekongestanty: starye preparaty i novye formy. Doktor.ru. 2011; 6 (65): 17–23. [in Russian]
4. Stewart M, Ferguson BJ, Fromer L. Epidemiology and burden of nasal congestion. Int J Gen Med 2010; 3: 37–45.
5. Naclerio RM, Bachert C, Baraniuk JN. Pathophysiology of nasal congestion. Int J Gen Med 2010; 3: 47–57
6. http://glav-otolar/documents
7. Lopatin A.S. Rinit. M.: Literra, 2010. [in Russian]
8. Shaikh N, Wald ER. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev 2014; 10: CD007909
9. Coleman C, Moore M. Decongestants and antihistamines for acute otitis media in children. Cochrane Database Syst Rev 2008; 3: CD001727
10. Griffin G, Flynn CA. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2011; 9: CD003423
11. Hofmann T, Wolf G, Koidl B. In vitro studies of the effect of vasoconstrictor nose drops on ciliary epithelium of human nasal mucosa. Laryngorhinootologie 1995; 74 (9): 564–7.
12. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8.
13. Graf P, Hallen H. Effect on the nasal mucosaof long-term treatment with oxymetasoline, bensalconium chloride, and placebo nasal sprays. Laryngoscope 1996; 106 (5; Pt. 1): 605–9.
14. Knipping S, Holzhausen HJ, Riederer A, Bloching M. Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa. HNO 2006; 54 (10): 742–8.
15. Kunel'skaia N.L., Tsarapkin G.Iu., Artem'ev M.E. i dr. Konservativnoe lechenie khimicheskogo povrezhdeniia. Med. sovet. 2013; 3: 63–4. [in Russian]
16. Proctor DW, Adams GK. Physiology and pharmacology of nasal function and mucous secretion. Pharmacol Ther Bull 1976; 2: 493–509.
17. Montalban J, Ibanez L, Rodriguez C et al. Cerebral infarction after excessive use of nasal decongestants. J Neurol Neurosurg Psychiatry 1989; 52: 541–43.
18. Wenzel S, Sagowski C, Laux G et al. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83.
19. Kalashnikova O.V., Chelpachenko O.E. Kliniko-laboratornaia kharakteristika otravlenii topicheskimi dekongestantami u detei. Vestnik OGU. 2013; 9 (158): 96–9. [in Russian]
20. Hosemann W, Göde U, Länger F, Wigand ME. Experimental studies of wound healing in the paranasal sinuses. II. Spontaneous wound healing and drug effects in a standardized wound model. HNO 1991; 39 (2): 48–54.
21. Hosemann W, Wigand ME, Göde U et al. Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol 1991; 248 (7): 390–4.
22. Verse T, Klöcker N, Riedel F et al. Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance. HNO 2004; 52 (7): 611–5.
23. Klocker N, Verse T, Rudolph P. The protective effect of dexpanthenol in nasal sprays and ciliary-toxic studies in vitro. Laryngorhinootologie 2003; 82 (3): 177–82.
24. Klocker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effect of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol 2004; 18 (5): 315–20.
25. Kehrl W, Sonnemann U, Dethlefsen U. Advance in therapy of acute rhinitis – comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis. Laryngorhinootologie 2003; 82 (4): 266–71.
26. Jagade Mahan V, Langade Deepak G, Pophale Rupesh R, Prabhu Arun. Oxymetazolyn and dexpanthenol in nasal congestion. Indian J Otolaryngol Head Neck Surg 2008; 60: 393–7.
27. Kehrl W, Sonnemann U. Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior. Laryngorhinootologie 1998; 77 (9): 506–12.
28. Kehrl W, Sonnemann U. Improving wound healing after nose surgery by combined flvinistration of xylometazoline and dexpanthenol. Laryngorhinootologie 2000; 79 (3): 151–4.
29. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic Acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy Volume 2014, Article ID 635490, 10 pages http://dx.doi.org/10.1155/2014/635490
30. Dannye kompanii KRKA. [in Russian]
Авторы
Д.П.Поляков*
ФГБУ Научно-клинический центр оториноларингологии ФМБА России. 123182, Россия, Москва, Волоколамское ш., д. 30, корп. 2
*child.lor@yandex.ru
Research and Clinical Center of Otorhinolaryngology. 123182, Russian Federation, Moscow, Volokolamskoe sh., d. 30, korp. 2
*child.lor@yandex.ru
ФГБУ Научно-клинический центр оториноларингологии ФМБА России. 123182, Россия, Москва, Волоколамское ш., д. 30, корп. 2
*child.lor@yandex.ru
________________________________________________
Research and Clinical Center of Otorhinolaryngology. 123182, Russian Federation, Moscow, Volokolamskoe sh., d. 30, korp. 2
*child.lor@yandex.ru
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