Хроническая тромбоэмболическая легочная гипертензия (ХТЭЛГ) – прогрессирующее заболевание, развивающееся вследствие хронической обструкции легочных артерий, приводящей к устойчивому повышению легочного сосудистого сопротивления и правожелудочковой недостаточности. Метод выбора лечения ХТЭЛГ – эндартерэктомия – у целого ряда больных противопоказан вследствие высокого риска хирургического вмешательства и/или технической невозможности операции при дистальном типе поражения легочного сосудистого русла. Транслюминальная ангиопластика легочных артерий у неоперабельных больных ХТЭЛГ является эффективным методом лечения, имеющим большие перспективы.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease, developing as a result of chronic obstructive pulmonary disease leading to sustainable elevation in pulmonary vascular resistance and right ventricular failure. The selected method for CTEPH treatment is endarterectomy but in a number of patients this method is contraindicated because of high-risk surgery and/or technical impossibility of surgery in case of damage to the distal pulmonary arteries. Transluminal pulmonary angioplasty in patients with inoperable CTEPH is an effective method for the treatment, of great further prospects.
1. Lewczuk J, Piszko P, Jagas J et al. Prognostic factors in medically treated patients with chronic pulmonary embolism. Chest 2001; 119 (3): 818–23. doi: 10.1378/chest.119.3.818.
2. Kim NH, Delcroix M, Jenkins DP et al. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 2013; 62 (25 Suppl.): D92–9. doi: 10.1016/j.jacc.2013.10.024.
3. Madani MM, Auger WR, Pretorius V et al. Pulmonary endarterectomy: recent changes in a single institution’s experience of more than 2,700 patients. Ann Thorac Surg 2012; 94 (1): 97–103. doi: 10.1016/j.athoracsur.2012.04.004.
4. Pepke-Zaba J, Delcroix M, Lang I et al. Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry. Circulation 2011; 124 (18): 1973–81. doi:10.1161/ CIRCULATIONAHA.110.015008.
5. Ghofrani HA, D’Armini AM, Grimminger F et al. Riociguat for the treatment of chronic thromboembolic pulmonary hyperten- sion. N Engl J Med 2013; 369 (4): 319–29. doi: 10.1056/NEJMoa1209657.
6. Lock JE, Castaneda-Zuniga WR, Fuhrman BP, Bass JL. Balloon dilation angioplasty of hypoplastic and stenotic pulmonary arteries. Circulation 1983; 67 (5): 962–7. doi: 10.1161/01.CIR.67.5.962.
7. Voorburg JA, Cats VM, Buis B, Bruschke AV. Balloon angioplasty in the treatment of pulmonary hypertension caused by pulmonary embolism. Chest 1988; 94 (6): 1249–53. doi: 10.1378/chest.94.6.1249.
8. Feinstein JA, Goldhaber SZ, Lock JE et al. Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. Circulation 2001; 103 (1): 10–3. doi: 10.1161/01.CIR.103.1.10.
9. Mizoguchi H, Ogawa A, Munemasa M et al. Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv 2012; 5 (6): 748–55. doi: 10.1161/Circinterventions.112.971077.
10. Sugimura K, Fukumoto Y, Satoh K et al. Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboem- bolic pulmonary hypertension. Circ J 2012; 76 (2): 485–8. doi: 10.1253/circj.CJ-11-1217.
11. Kataoka M, Inami T, Hayashida K et al. Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv 2012; 5 (6): 756–62. doi: 10.1161/Circinterventions.112.971390.
12. Galiè N, Humbert M, Vachiery JL et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J 2016; 37 (1): 67–119. doi: 10.1093/eurheartj/ehv317. Epub 2015 Aug 29.
13. Inami T, Kataoka M, Ishiguro H et al. Per-cutaneous transluminal pulmonary angioplasty for chronic thromboembolic pulmonary hypertension with severe right heart failure. Am J Respir Crit Care Med 2014; 189 (11): 1437–9. doi: 10.1164/rccm.201312- 2254LE.
14. Sugiyama M, Fukuda T, Sanda Y et al. Organized thrombus in pulmonary & arteries in patients with chronic thromboembolic pulmonary hypertension; imaging with cone beam computed tomography. Jpn J Radiol 2014; 32: 375–82.
15. Vincent R et al. Antecubital vs Femoral Venous Access for Right Heart Catheterization: Benefits of a Flashback Roule. Can J Cardiol 2015; 31 (12): 1497.e1–1497.e6.
16. Osorio J, Russek M. Reflex changes on the pulmonary and systemic pressures elicited by stimulation of baroreceptors in the pulmonary artery. Circ Res 1962; 10: 664–7.
17. Inami T, Kataoka M, Ando M et al. A new era of therapeutic strategies for & chronic thromboembolic pulmonary hypertension by two different interven- tional therapies; pulmonary endarterectomy and percutaneous transluminal pulmonary angioplasty. PLoS One 2014; 9: e94587.
18. Taniguchi Y, Miyagawa K, Nakayama K et al. Balloon pulmonary angioplasty: An additional treatment option to improve the prognosis of patients with chronic thromboembolic pulmonary hypertension. Eur Int 2014; 10: 518–25.
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1. Lewczuk J, Piszko P, Jagas J et al. Prognostic factors in medically treated patients with chronic pulmonary embolism. Chest 2001; 119 (3): 818–23. doi: 10.1378/chest.119.3.818.
2. Kim NH, Delcroix M, Jenkins DP et al. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 2013; 62 (25 Suppl.): D92–9. doi: 10.1016/j.jacc.2013.10.024.
3. Madani MM, Auger WR, Pretorius V et al. Pulmonary endarterectomy: recent changes in a single institution’s experience of more than 2,700 patients. Ann Thorac Surg 2012; 94 (1): 97–103. doi: 10.1016/j.athoracsur.2012.04.004.
4. Pepke-Zaba J, Delcroix M, Lang I et al. Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry. Circulation 2011; 124 (18): 1973–81. doi:10.1161/ CIRCULATIONAHA.110.015008.
5. Ghofrani HA, D’Armini AM, Grimminger F et al. Riociguat for the treatment of chronic thromboembolic pulmonary hyperten- sion. N Engl J Med 2013; 369 (4): 319–29. doi: 10.1056/NEJMoa1209657.
6. Lock JE, Castaneda-Zuniga WR, Fuhrman BP, Bass JL. Balloon dilation angioplasty of hypoplastic and stenotic pulmonary arteries. Circulation 1983; 67 (5): 962–7. doi: 10.1161/01.CIR.67.5.962.
7. Voorburg JA, Cats VM, Buis B, Bruschke AV. Balloon angioplasty in the treatment of pulmonary hypertension caused by pulmonary embolism. Chest 1988; 94 (6): 1249–53. doi: 10.1378/chest.94.6.1249.
8. Feinstein JA, Goldhaber SZ, Lock JE et al. Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. Circulation 2001; 103 (1): 10–3. doi: 10.1161/01.CIR.103.1.10.
9. Mizoguchi H, Ogawa A, Munemasa M et al. Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv 2012; 5 (6): 748–55. doi: 10.1161/Circinterventions.112.971077.
10. Sugimura K, Fukumoto Y, Satoh K et al. Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboem- bolic pulmonary hypertension. Circ J 2012; 76 (2): 485–8. doi: 10.1253/circj.CJ-11-1217.
11. Kataoka M, Inami T, Hayashida K et al. Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv 2012; 5 (6): 756–62. doi: 10.1161/Circinterventions.112.971390.
12. Galiè N, Humbert M, Vachiery JL et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J 2016; 37 (1): 67–119. doi: 10.1093/eurheartj/ehv317. Epub 2015 Aug 29.
13. Inami T, Kataoka M, Ishiguro H et al. Per-cutaneous transluminal pulmonary angioplasty for chronic thromboembolic pulmonary hypertension with severe right heart failure. Am J Respir Crit Care Med 2014; 189 (11): 1437–9. doi: 10.1164/rccm.201312- 2254LE.
14. Sugiyama M, Fukuda T, Sanda Y et al. Organized thrombus in pulmonary & arteries in patients with chronic thromboembolic pulmonary hypertension; imaging with cone beam computed tomography. Jpn J Radiol 2014; 32: 375–82.
15. Vincent R et al. Antecubital vs Femoral Venous Access for Right Heart Catheterization: Benefits of a Flashback Roule. Can J Cardiol 2015; 31 (12): 1497.e1–1497.e6.
16. Osorio J, Russek M. Reflex changes on the pulmonary and systemic pressures elicited by stimulation of baroreceptors in the pulmonary artery. Circ Res 1962; 10: 664–7.
17. Inami T, Kataoka M, Ando M et al. A new era of therapeutic strategies for & chronic thromboembolic pulmonary hypertension by two different interven- tional therapies; pulmonary endarterectomy and percutaneous transluminal pulmonary angioplasty. PLoS One 2014; 9: e94587.
18. Taniguchi Y, Miyagawa K, Nakayama K et al. Balloon pulmonary angioplasty: An additional treatment option to improve the prognosis of patients with chronic thromboembolic pulmonary hypertension. Eur Int 2014; 10: 518–25.
Авторы
Н.М.Данилов*, Ю.Г.Матчин, И.Е.Чазова
ФГБУ Российский кардиологический научно-производственный комплекс Минздрава России. 121552, Россия, Москва, ул. 3-я Черепковская, д. 15а
*ndanilov1@gmail.com
________________________________________________
N.M.Danilov*, Yu.G.Matchin, I.E.Chazova
Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation. 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15a
*ndanilov1@gmail.com