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Омега-3-жирные кислоты в кардиологической практике
Васильев А.П., Стрельцова Н.Н. Омега-3-жирные кислоты в кардиологической практике. Consilium Medicum. 2017; 19 (10): 96–104. DOI: 10.26442/2075-1753_19.10.96-104
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Vasilev A.P., Streltsova N.N. Omega-3 fatty acids in cardiology practice. Consilium Medicum. 2017; 19 (10): 96–104. DOI: 10.26442/2075-1753_19.10.96-104
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Аннотация
Эссенциальные жирные кислоты семейства омега-3 определяют жизненно важные процессы в организме. В многочисленных исследованиях продемонстрировано, что восполнение дефицита этих нутриентов, обусловленного особенностями современного питания, увеличением в пищевом рационе рыбы, ведет к уменьшению сердечно-сосудистой заболеваемости. Включение в терапию омега-3-полиненасыщенных жирных кислот в капсулах значительно снижает риск внезапной смерти у больных после инфаркта миокарда, увеличивает выживаемость при сердечной недостаточности, оказывает антиаритмический эффект. Цель настоящего обзора – еще раз привлечь внимание врачей к этому важному разделу медицины, напомнить о целесообразности использования омега-3-жирных кислот в качестве эффективных средств первичной и вторичной профилактики сердечно-сосудистой патологии, необходимости более широкого их применения у больных с инфарктом миокарда, при сердечной недостаточности, включении в комплексное лечение аритмии.
Ключевые слова: омега-3-жирные кислоты, сердечно-сосудистые заболевания.
Ключевые слова: омега-3-жирные кислоты, сердечно-сосудистые заболевания.
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Omega-3 essential fatty acids have major roles in all sorts of bodily processes. Numerous observational studies demonstrate that increase consumption of fishmeal as a replacement of the nutrient deficiency caused by modern dietary habits tends to reduce risk of cardiovascular diseases. Taking omega 3 fatty acids capsules during therapy may significantly reduce sudden cardiac death in patients with a history of myocardial infarction; improve survival in congestive heart failure patients; possess antiarrhythmic effect. The main purpose of this review is to draw attention of doctors to this important therapeutic area and to remind that the use of omega-3 fatty acids is appropriate and effective for primary and secondary prevention of cardiovascular diseases, as well as to emphasize the necessity of its wide-ranging use in patients with myocardial infarction, heart failure, and adding in the combination therapy of arrhythmia.
Key words: omega-3 fatty acids, cardiovascular diseases.
Полный текст
Список литературы
1. Albert CM, Campos H, Stampler MJ et al. Blood PUFAs and the risk of sudden death. N Engl J Med 2002; 346: 1113–8.
2. Mozaffarian D, Lemaitre RN, Kuller LH et al. Cardiac Benefits of Fish Consumption May Depend onthe Type of Fish Meal Consumed. Circulation 2003; 107: 1372–7.
3. Chrysohoou C, Panagiotakos DB, Pitsavos C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol 2004; 44: 152–8.
4. Iso H, Rexrode KM, Stampfer MJ. Intake of fish and omega-3 fatty acids and risk of stroke in women. J Am Med Assoc 2000; 285: 304–12.
5. Shekele RB, Missell LV, Paul O et al. Fish consumption and mortality from coronary heart disease. N Engl J Med 1985; 313: 820.
6. Hu FB, Bronner L, Willett WC et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287: 1815–21.
7. Daviglus ML Stamler J, Orencia AJ et al. Fish consumption and the 30 year risk of fatal myocardial infarction. N Engl J Med 1997; 336: 1046–53.
8. Kromhout D, Bosschieter EB, Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1990; 7: 173–6.
9. Kris-Etherton PM. Fish consumption, fish oil, omega-3 fatty acids and cardiovasculardisease. Circulation 2002; 106: 2747–57.
10. Siscovick DS, Raghunathan TE et al. Dietary intake and cell membrane levels of long chain o3 – polyunsaturated fatty acids and the risk of primary cardiac arrest. J Am Med Assoc 1995; 274: 1363–7.
11. Keli SO et al. Fish consumption and risk of stroke: the Zutphen Study. Stroke 1994; 25: 328–32.
12. Caro J, Klittich W, McGuire A. The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin. BMJ 1997; 315: 1577–82.
13. Myerburg RJ, Spooner PM. Opportunities for sudden death prevention: Directions for new clinical and basic research. Cardiovasc Res 2001; 50: 177–85.
14. Priori G, Aliot E, Blomstrom-Lundqvist C et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 2001; 22: 1374–450.
15. Burr ML, Fehily AM, Gilbert JF et al. Effects ofchanges in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 2 (8666): 757–61.
16. Erkkila AT, Mattman NR, Herrington DM, Lichtenstein AH. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. J Lipid Res 2006; 47: 2814–9.
17. Результаты исследования OCEAN (Omacor Carotid Endarterectomy Intervention Trial). XIV Международный симпозиум по атеросклерозу. Рим, 18–22 июня 2006. / Rezul'taty issledovaniia OCEAN (Omacor Carotid Endarterectomy Intervention Trial). XIV Mezhdunarodnyi simpozium po aterosklerozu. Rim, 18–22 iiunia 2006. [in Russian]
18. Eritsland J, Arnesen H, Gronseth Ket al. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol 1996; 77: 31–6.
19. Hooper L, Thompson RL, Harrison RA et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. Br Med J 2006; 332: 752–60.
20. Harris WS, Ginsberg HN, Arunakul N et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 1997; 4 (5/6): 385–91.
21. Dietary supplementation with o-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447–55.
22. GISSI-HF investigators. Effekt of n-3 polyunsaturated acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 2008; 372: 1223.
23. Nodari S, Triggiani M, Campia U et al. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 2011; 57: 870–9.
24. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death. Eur Heart J 2006; 27: 2099–140.
25. Leaf A et al. Membrane Effects of the n_3 Fish Oil Fatty Acids, which Prevent Fatal Ventricular Arrhythmias. J Membr Biol 2005; 206 (2): 129–39.
26. Xiao YF et al. The Antiarrhythmic Effect of n_3 Polyunsaturated Fatty Acids: Modulation of Cardiac Ion Channelsas a Potential Mechanism. J Membr Biol 2005; 206 (2): 141–54.
27. Васильев А.П., Стрельцова Н.Н., Секисова М.А. и др. Клинико-профилактические аспекты применения омега-3 жирных кислот в медицине. Тюмень: Экспресс, 2010. / Vasil'ev A.P., Strel'tsova N.N., Sekisova M.A. i dr. Kliniko-profilakticheskie aspekty primeneniia omega-3 zhirnykh kislot v meditsine. Tiumen': Ekspress, 2010. [in Russian]
28. Calo L, Biabconi L, Colivicchi F et al. N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol 2005; 45: 1723–8.
29. Singer P, Wirth M. Can omega-3 polyunsaturated fatty acids reduce cardiac arrhythmias? Results of a clinical trial. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 153–9.
30. Нифонтов Е.М., Шихалиев Д.Р., Богачев М.И. и др. Антиаритмическая эффективность омега-3 полиненасыщенных жирных кислот у больных стабильной ишемической болезнью сердца с желудочковыми нарушениями ритма. Кардиология. 2010; 12: 41–6. / Nifontov E.M., Shikhaliev D.R., Bogachev M.I. i dr. Antiaritmicheskaia effektivnost' omega-3 polinenasyshchennykh zhirnykh kislot u bol'nykh stabil'noi ishemicheskoi bolezn'iu serdtsa s zheludochkovymi narusheniiami ritma. Kardiologiia. 2010; 12: 41–6. [in Russian]
31. Дженкинс Н.П., Дэвидсон Н.К., Беннет Д.Г. Успешное лечение желудочковой тахикардии, рефрактерной к медикаментозной терапии, при дополнительном назначении препарата омега-3 полиненасыщенных жирных кислот. Обзоры клин. кардиологии. 2009; 18: 10–4. / Dzhenkins N.P., Devidson N.K., Bennet D.G. Uspeshnoe lechenie zheludochkovoi takhikardii, refrakternoi k medikamentoznoi terapii, pri dopolnitel'nom naznachenii preparata omega-3 polinenasyshchennykh zhirnykh kislot. Obzory klin. kardiologii. 2009; 18: 10–4. [in Russian]
32. Biscione F, Totteri A, De Vita A et al. Effect of omega-3 fatty acids on the prevention of atrial arrhythmias [in Italian]. Ital Heart J (Suppl.) 2005; 6: 53–9.
33. Chee KM, Gong JX, Rees DMG et al. Fatty acid content of marine oil capsules. Lipids 1990; 25 (9): 523–8.
34. Есинов А.В. Омега-3 жирные кислоты в медицине: диагностика, подходы к лечению. Автореф. дис. … канд. биол. наук. 2012. / Esinov A.V. Omega-3 zhirnye kisloty v meditsine: diagnostika, podkhody k lecheniiu. Avtoref. dis. … kand. biol. nauk. 2012. [in Russian]
35. Громова О.А., Торшин И.Ю., Калачева А.Г., Грачева О.Н. Мировой опыт омега-3 ПНЖК. Крупномасштабные клинические исследования омега-3 ПНЖК: об эффективности, доказательности и перспективах. Сердце. 2011; 5: 263–72. / Gromova O.A., Torshin I.Iu., Kalacheva A.G., Gracheva O.N. Mirovoi opyt omega-3 PNZhK. Krupnomasshtabnye klinicheskie issledovaniia omega-3 PNZhK: ob effektivnosti, dokazatel'nosti i perspektivakh. Serdtse. 2011; 5: 263–72. [in Russian]
2. Mozaffarian D, Lemaitre RN, Kuller LH et al. Cardiac Benefits of Fish Consumption May Depend onthe Type of Fish Meal Consumed. Circulation 2003; 107: 1372–7.
3. Chrysohoou C, Panagiotakos DB, Pitsavos C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol 2004; 44: 152–8.
4. Iso H, Rexrode KM, Stampfer MJ. Intake of fish and omega-3 fatty acids and risk of stroke in women. J Am Med Assoc 2000; 285: 304–12.
5. Shekele RB, Missell LV, Paul O et al. Fish consumption and mortality from coronary heart disease. N Engl J Med 1985; 313: 820.
6. Hu FB, Bronner L, Willett WC et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287: 1815–21.
7. Daviglus ML Stamler J, Orencia AJ et al. Fish consumption and the 30 year risk of fatal myocardial infarction. N Engl J Med 1997; 336: 1046–53.
8. Kromhout D, Bosschieter EB, Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1990; 7: 173–6.
9. Kris-Etherton PM. Fish consumption, fish oil, omega-3 fatty acids and cardiovasculardisease. Circulation 2002; 106: 2747–57.
10. Siscovick DS, Raghunathan TE et al. Dietary intake and cell membrane levels of long chain o3 – polyunsaturated fatty acids and the risk of primary cardiac arrest. J Am Med Assoc 1995; 274: 1363–7.
11. Keli SO et al. Fish consumption and risk of stroke: the Zutphen Study. Stroke 1994; 25: 328–32.
12. Caro J, Klittich W, McGuire A. The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin. BMJ 1997; 315: 1577–82.
13. Myerburg RJ, Spooner PM. Opportunities for sudden death prevention: Directions for new clinical and basic research. Cardiovasc Res 2001; 50: 177–85.
14. Priori G, Aliot E, Blomstrom-Lundqvist C et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 2001; 22: 1374–450.
15. Burr ML, Fehily AM, Gilbert JF et al. Effects ofchanges in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 2 (8666): 757–61.
16. Erkkila AT, Mattman NR, Herrington DM, Lichtenstein AH. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. J Lipid Res 2006; 47: 2814–9.
17. Результаты исследования OCEAN (Omacor Carotid Endarterectomy Intervention Trial). XIV Международный симпозиум по атеросклерозу. Рим, 18–22 июня 2006. / Rezul'taty issledovaniia OCEAN (Omacor Carotid Endarterectomy Intervention Trial). XIV Mezhdunarodnyi simpozium po aterosklerozu. Rim, 18–22 iiunia 2006. [in Russian]
18. Eritsland J, Arnesen H, Gronseth Ket al. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol 1996; 77: 31–6.
19. Hooper L, Thompson RL, Harrison RA et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. Br Med J 2006; 332: 752–60.
20. Harris WS, Ginsberg HN, Arunakul N et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 1997; 4 (5/6): 385–91.
21. Dietary supplementation with o-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447–55.
22. GISSI-HF investigators. Effekt of n-3 polyunsaturated acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 2008; 372: 1223.
23. Nodari S, Triggiani M, Campia U et al. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 2011; 57: 870–9.
24. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death. Eur Heart J 2006; 27: 2099–140.
25. Leaf A et al. Membrane Effects of the n_3 Fish Oil Fatty Acids, which Prevent Fatal Ventricular Arrhythmias. J Membr Biol 2005; 206 (2): 129–39.
26. Xiao YF et al. The Antiarrhythmic Effect of n_3 Polyunsaturated Fatty Acids: Modulation of Cardiac Ion Channelsas a Potential Mechanism. J Membr Biol 2005; 206 (2): 141–54.
27. Васильев А.П., Стрельцова Н.Н., Секисова М.А. и др. Клинико-профилактические аспекты применения омега-3 жирных кислот в медицине. Тюмень: Экспресс, 2010. / Vasil'ev A.P., Strel'tsova N.N., Sekisova M.A. i dr. Kliniko-profilakticheskie aspekty primeneniia omega-3 zhirnykh kislot v meditsine. Tiumen': Ekspress, 2010. [in Russian]
28. Calo L, Biabconi L, Colivicchi F et al. N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol 2005; 45: 1723–8.
29. Singer P, Wirth M. Can omega-3 polyunsaturated fatty acids reduce cardiac arrhythmias? Results of a clinical trial. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 153–9.
30. Нифонтов Е.М., Шихалиев Д.Р., Богачев М.И. и др. Антиаритмическая эффективность омега-3 полиненасыщенных жирных кислот у больных стабильной ишемической болезнью сердца с желудочковыми нарушениями ритма. Кардиология. 2010; 12: 41–6. / Nifontov E.M., Shikhaliev D.R., Bogachev M.I. i dr. Antiaritmicheskaia effektivnost' omega-3 polinenasyshchennykh zhirnykh kislot u bol'nykh stabil'noi ishemicheskoi bolezn'iu serdtsa s zheludochkovymi narusheniiami ritma. Kardiologiia. 2010; 12: 41–6. [in Russian]
31. Дженкинс Н.П., Дэвидсон Н.К., Беннет Д.Г. Успешное лечение желудочковой тахикардии, рефрактерной к медикаментозной терапии, при дополнительном назначении препарата омега-3 полиненасыщенных жирных кислот. Обзоры клин. кардиологии. 2009; 18: 10–4. / Dzhenkins N.P., Devidson N.K., Bennet D.G. Uspeshnoe lechenie zheludochkovoi takhikardii, refrakternoi k medikamentoznoi terapii, pri dopolnitel'nom naznachenii preparata omega-3 polinenasyshchennykh zhirnykh kislot. Obzory klin. kardiologii. 2009; 18: 10–4. [in Russian]
32. Biscione F, Totteri A, De Vita A et al. Effect of omega-3 fatty acids on the prevention of atrial arrhythmias [in Italian]. Ital Heart J (Suppl.) 2005; 6: 53–9.
33. Chee KM, Gong JX, Rees DMG et al. Fatty acid content of marine oil capsules. Lipids 1990; 25 (9): 523–8.
34. Есинов А.В. Омега-3 жирные кислоты в медицине: диагностика, подходы к лечению. Автореф. дис. … канд. биол. наук. 2012. / Esinov A.V. Omega-3 zhirnye kisloty v meditsine: diagnostika, podkhody k lecheniiu. Avtoref. dis. … kand. biol. nauk. 2012. [in Russian]
35. Громова О.А., Торшин И.Ю., Калачева А.Г., Грачева О.Н. Мировой опыт омега-3 ПНЖК. Крупномасштабные клинические исследования омега-3 ПНЖК: об эффективности, доказательности и перспективах. Сердце. 2011; 5: 263–72. / Gromova O.A., Torshin I.Iu., Kalacheva A.G., Gracheva O.N. Mirovoi opyt omega-3 PNZhK. Krupnomasshtabnye klinicheskie issledovaniia omega-3 PNZhK: ob effektivnosti, dokazatel'nosti i perspektivakh. Serdtse. 2011; 5: 263–72. [in Russian]
________________________________________________
1. Albert CM, Campos H, Stampler MJ et al. Blood PUFAs and the risk of sudden death. N Engl J Med 2002; 346: 1113–8.
2. Mozaffarian D, Lemaitre RN, Kuller LH et al. Cardiac Benefits of Fish Consumption May Depend onthe Type of Fish Meal Consumed. Circulation 2003; 107: 1372–7.
3. Chrysohoou C, Panagiotakos DB, Pitsavos C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol 2004; 44: 152–8.
4. Iso H, Rexrode KM, Stampfer MJ. Intake of fish and omega-3 fatty acids and risk of stroke in women. J Am Med Assoc 2000; 285: 304–12.
5. Shekele RB, Missell LV, Paul O et al. Fish consumption and mortality from coronary heart disease. N Engl J Med 1985; 313: 820.
6. Hu FB, Bronner L, Willett WC et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287: 1815–21.
7. Daviglus ML Stamler J, Orencia AJ et al. Fish consumption and the 30 year risk of fatal myocardial infarction. N Engl J Med 1997; 336: 1046–53.
8. Kromhout D, Bosschieter EB, Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1990; 7: 173–6.
9. Kris-Etherton PM. Fish consumption, fish oil, omega-3 fatty acids and cardiovasculardisease. Circulation 2002; 106: 2747–57.
10. Siscovick DS, Raghunathan TE et al. Dietary intake and cell membrane levels of long chain o3 – polyunsaturated fatty acids and the risk of primary cardiac arrest. J Am Med Assoc 1995; 274: 1363–7.
11. Keli SO et al. Fish consumption and risk of stroke: the Zutphen Study. Stroke 1994; 25: 328–32.
12. Caro J, Klittich W, McGuire A. The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin. BMJ 1997; 315: 1577–82.
13. Myerburg RJ, Spooner PM. Opportunities for sudden death prevention: Directions for new clinical and basic research. Cardiovasc Res 2001; 50: 177–85.
14. Priori G, Aliot E, Blomstrom-Lundqvist C et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 2001; 22: 1374–450.
15. Burr ML, Fehily AM, Gilbert JF et al. Effects ofchanges in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 2 (8666): 757–61.
16. Erkkila AT, Mattman NR, Herrington DM, Lichtenstein AH. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. J Lipid Res 2006; 47: 2814–9.
17. Rezul'taty issledovaniia OCEAN (Omacor Carotid Endarterectomy Intervention Trial). XIV Mezhdunarodnyi simpozium po aterosklerozu. Rim, 18–22 iiunia 2006. [in Russian]
18. Eritsland J, Arnesen H, Gronseth Ket al. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol 1996; 77: 31–6.
19. Hooper L, Thompson RL, Harrison RA et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. Br Med J 2006; 332: 752–60.
20. Harris WS, Ginsberg HN, Arunakul N et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 1997; 4 (5/6): 385–91.
21. Dietary supplementation with o-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447–55.
22. GISSI-HF investigators. Effekt of n-3 polyunsaturated acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 2008; 372: 1223.
23. Nodari S, Triggiani M, Campia U et al. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 2011; 57: 870–9.
24. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death. Eur Heart J 2006; 27: 2099–140.
25. Leaf A et al. Membrane Effects of the n_3 Fish Oil Fatty Acids, which Prevent Fatal Ventricular Arrhythmias. J Membr Biol 2005; 206 (2): 129–39.
26. Xiao YF et al. The Antiarrhythmic Effect of n_3 Polyunsaturated Fatty Acids: Modulation of Cardiac Ion Channelsas a Potential Mechanism. J Membr Biol 2005; 206 (2): 141–54.
27. Vasil'ev A.P., Strel'tsova N.N., Sekisova M.A. i dr. Kliniko-profilakticheskie aspekty primeneniia omega-3 zhirnykh kislot v meditsine. Tiumen': Ekspress, 2010. [in Russian]
28. Calo L, Biabconi L, Colivicchi F et al. N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol 2005; 45: 1723–8.
29. Singer P, Wirth M. Can omega-3 polyunsaturated fatty acids reduce cardiac arrhythmias? Results of a clinical trial. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 153–9.
30. Nifontov E.M., Shikhaliev D.R., Bogachev M.I. i dr. Antiaritmicheskaia effektivnost' omega-3 polinenasyshchennykh zhirnykh kislot u bol'nykh stabil'noi ishemicheskoi bolezn'iu serdtsa s zheludochkovymi narusheniiami ritma. Kardiologiia. 2010; 12: 41–6. [in Russian]
31. Dzhenkins N.P., Devidson N.K., Bennet D.G. Uspeshnoe lechenie zheludochkovoi takhikardii, refrakternoi k medikamentoznoi terapii, pri dopolnitel'nom naznachenii preparata omega-3 polinenasyshchennykh zhirnykh kislot. Obzory klin. kardiologii. 2009; 18: 10–4. [in Russian]
32. Biscione F, Totteri A, De Vita A et al. Effect of omega-3 fatty acids on the prevention of atrial arrhythmias [in Italian]. Ital Heart J (Suppl.) 2005; 6: 53–9.
33. Chee KM, Gong JX, Rees DMG et al. Fatty acid content of marine oil capsules. Lipids 1990; 25 (9): 523–8.
34. Esinov A.V. Omega-3 zhirnye kisloty v meditsine: diagnostika, podkhody k lecheniiu. Avtoref. dis. … kand. biol. nauk. 2012. [in Russian]
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Авторы
А.П.Васильев*, Н.Н.Стрельцова
Тюменский кардиологический научный центр – филиал ФГБНУ «Томский национальный исследовательский медицинский центр РАН». 625026, Россия, Тюмень, ул. Мельникайте, д. 111
*sss@cardio.tmn.ru
Тюменский кардиологический научный центр – филиал ФГБНУ «Томский национальный исследовательский медицинский центр РАН». 625026, Россия, Тюмень, ул. Мельникайте, д. 111
*sss@cardio.tmn.ru
________________________________________________
A.P.Vasilev*, N.N.Streltsova
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Science. 625026, Russian Federation, Tiumen', ul. Mel'nikaite, d. 111
*sss@cardio.tmn.ru
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