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Современные возможности лечения артериальной гипертензии у пациентов пожилого возраста
Современные возможности лечения артериальной гипертензии у пациентов пожилого возраста
Чукаева И.И., Спирякина Я.Г., Литвинова С.Н. и др. Современные возможности лечения артериальной гипертензии у пациентов пожилого возраста. Consilium Medicum. 2017; 19 (10): 19–24. DOI: 10.26442/2075-1753_19.10.19-24
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Аннотация
Пациенты пожилого возраста с артериальной гипертензией практически всегда относятся к категории высокого и очень высокого риска сердечно-сосудистых осложнений. В статье рассматриваются вопросы выбора оптимальной комбинированной терапии пожилых, возможности повышения приверженности лечению, обсуждаются преимущества тройной фиксированной комбинации периндоприла/индапамида/амлодипина с позиций доказательной медицины.
Ключевые слова: пожилые пациенты, артериальная гипертензия, комбинированная антигипертензивная терапия, фиксированные комбинации, периндоприл, индапамид, амлодипин.
Key words: elderly patients, arterial hypertension, combined antihypertensive therapy, fixed combinations, perindopril, indapamide, amlodipine.
Ключевые слова: пожилые пациенты, артериальная гипертензия, комбинированная антигипертензивная терапия, фиксированные комбинации, периндоприл, индапамид, амлодипин.
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Key words: elderly patients, arterial hypertension, combined antihypertensive therapy, fixed combinations, perindopril, indapamide, amlodipine.
Полный текст
Список литературы
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7. Adams HP, del Zoppo G, Alberts MJ et al. Guidelines for the early management of adults with ischemic stroke. A guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 2007; 38: 1655–711.
8. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension. Blood Press 2014; 23 (1): 3–16. DOI: 10.3109/08037051.2014.868629.HYVET
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10. The SPRINT Research Group. Randomized trial of intensive versusstandard blood-pressure control. N Engl J Med 2015; 373: 2103–16.
11. Dong C, Della-Morte D, Rundek T et al. Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention The Northern Manhattan Study. Hypertension 2016; 67: 520–6.
12. Micha R, Peñalvo JL, Cudhea F et al. Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States. JAMA 2017; 317 (9): 912–24. DOI: 10.1001/jama.2017.0947
13. Hess G. Medication utilization patterns and hypertension-related expenditures among patients who were switched from fixed-dose to free-combination antihypertensive therapy. PT 2008; 33: 652–66.
14. Zanchetti A, Liu L, Mancia G et al. Stroke in Hypertension Optimal Treatment (SHOT) trial: protocol and organization. J Hypertens 2013; 31 (e-Suppl. A).
15. Jürgens G, Graudal NA. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride. Cochrane Database Syst Rev 2003; 1: CD004022.
16. Cohen HW, Hailpern SM, Fang J, Alderman MH. Sodium intake and mortality in the NHANES II follow-up study. Am J Med 2006; 119 (3): 275.e7–14.
17. Taylor RS, Ashton KE, Moxham T et al. Reduced dietary salt for the prevention of cardiovascular disease: a meta-analysis of randomized controlled trials (Cochrane review). Am J Hypertens 2011; 24 (8): 843–53. DOI: 10.1038/ajh.2011.115
18. Garg R, Williams GH, Hurwitz S et al. Low-salt diet increases insulin resistance in healthy subjects. Metabolism 2011; 60 (7): 965–8. DOI: 10.1016/j.metabol.2010.09.005
19. National Clinical Guideline Centre UK. Hypertension – the clinical management of primary hypertension in adults. August 2011. http://guidance.nice.org.uk/CG127
20. Thoenes M, Neuberger H, Volpe M. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24 (5): 336–44.
21. Beckett NS et al. Treatment of Hypertension in Patients 80 Years of Age or Older. N Engl J Med 2008; 358: 1887–29.
22. Dahlöf B, Sever PS, Poulter NR et al. ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366 (9489): 895–906.
23. Chalmers J, Arima H, Woodward M et al. Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial. Hypertension 2013; 63: 259–64.
24. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dos combinations of antihypertensive agents: a meta-analysis. Hypertension 2010; 55 (2): 399–407.
25. Makani H, Bangalore S, Romero J et al. Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema. Am J Med 2011; 124: 128–35.
26. Лутай М.И. Эффективность комбинированной терапии артериальной гипертензии в Украине: результаты многоцентрового исследования ТРИУМФ. Украинский кардиол. журн. 2016; 4: 17–28. / Lutai M.I. Effektivnost' kombinirovannoi terapii arterial'noi gipertenzii v Ukraine: rezul'taty mnogotsentrovogo issledovaniia TRIUMF. Ukrainskii kardiol. zhurn. 2016; 4: 17–28. [in Russian]
2. Australian Institute of Health and Welfare (AIHW): Chronic diseases and associated risk factors in Australia, 2006. Canberra: ACT, 2006.
3. Vertkin A.L., Rumiantsev M.A., Skotnikov A.S. Komorbidnost'. Klin. meditsina. 2012; 10: 4–11. [in Russian]
4. Chazova I.E. i dr. Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii. M., 2013. [in Russian]
5. Lazebnik L.B., Konev Iu.V., Drozdov V.N., Efremov L.I. Polipragmaziia: geriatricheskii aspekt problemy. Consilium Medicum. 2007; 9 (12): 29–34. [in Russian]
6. Tikhonoff V, Zhang H, Richart T et al. Blood pressure as a prognostic factor after acute stroke. Lancet Neurol 2009; 8: 938–48.
7. Adams HP, del Zoppo G, Alberts MJ et al. Guidelines for the early management of adults with ischemic stroke. A guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 2007; 38: 1655–711.
8. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension. Blood Press 2014; 23 (1): 3–16. DOI: 10.3109/08037051.2014.868629.HYVET
9. James PA, Oparil S, Carter BL et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth joint national committee (jnc 8). JAMA 2013.
10. The SPRINT Research Group. Randomized trial of intensive versusstandard blood-pressure control. N Engl J Med 2015; 373: 2103–16.
11. Dong C, Della-Morte D, Rundek T et al. Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention The Northern Manhattan Study. Hypertension 2016; 67: 520–6.
12. Micha R, Peñalvo JL, Cudhea F et al. Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States. JAMA 2017; 317 (9): 912–24. DOI: 10.1001/jama.2017.0947
13. Hess G. Medication utilization patterns and hypertension-related expenditures among patients who were switched from fixed-dose to free-combination antihypertensive therapy. PT 2008; 33: 652–66.
14. Zanchetti A, Liu L, Mancia G et al. Stroke in Hypertension Optimal Treatment (SHOT) trial: protocol and organization. J Hypertens 2013; 31 (e-Suppl. A).
15. Jürgens G, Graudal NA. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride. Cochrane Database Syst Rev 2003; 1: CD004022.
16. Cohen HW, Hailpern SM, Fang J, Alderman MH. Sodium intake and mortality in the NHANES II follow-up study. Am J Med 2006; 119 (3): 275.e7–14.
17. Taylor RS, Ashton KE, Moxham T et al. Reduced dietary salt for the prevention of cardiovascular disease: a meta-analysis of randomized controlled trials (Cochrane review). Am J Hypertens 2011; 24 (8): 843–53. DOI: 10.1038/ajh.2011.115
18. Garg R, Williams GH, Hurwitz S et al. Low-salt diet increases insulin resistance in healthy subjects. Metabolism 2011; 60 (7): 965–8. DOI: 10.1016/j.metabol.2010.09.005
19. National Clinical Guideline Centre UK. Hypertension – the clinical management of primary hypertension in adults. August 2011. http://guidance.nice.org.uk/CG127
20. Thoenes M, Neuberger H, Volpe M. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24 (5): 336–44.
21. Beckett NS et al. Treatment of Hypertension in Patients 80 Years of Age or Older. N Engl J Med 2008; 358: 1887–29.
22. Dahlöf B, Sever PS, Poulter NR et al. ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366 (9489): 895–906.
23. Chalmers J, Arima H, Woodward M et al. Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial. Hypertension 2013; 63: 259–64.
24. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dos combinations of antihypertensive agents: a meta-analysis. Hypertension 2010; 55 (2): 399–407.
25. Makani H, Bangalore S, Romero J et al. Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema. Am J Med 2011; 124: 128–35.
26. Lutai M.I. Effektivnost' kombinirovannoi terapii arterial'noi gipertenzii v Ukraine: rezul'taty mnogotsentrovogo issledovaniia TRIUMF. Ukrainskii kardiol. zhurn. 2016; 4: 17–28. [in Russian]
2. Australian Institute of Health and Welfare (AIHW): Chronic diseases and associated risk factors in Australia, 2006. Canberra: ACT, 2006.
3. Верткин А.Л., Румянцев М.А., Скотников А.С. Коморбидность. Клин. медицина. 2012; 10: 4–11. / Vertkin A.L., Rumiantsev M.A., Skotnikov A.S. Komorbidnost'. Klin. meditsina. 2012; 10: 4–11. [in Russian]
4. Чазова И.Е. и др. Диагностика и лечение артериальной гипертонии. Клинические рекомендации. М., 2013. / Chazova I.E. i dr. Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii. M., 2013. [in Russian]
5. Лазебник Л.Б., Конев Ю.В., Дроздов В.Н., Ефремов Л.И. Полипрагмазия: гериатрический аспект проблемы. Consilium Medicum. 2007; 9 (12): 29–34. / Lazebnik L.B., Konev Iu.V., Drozdov V.N., Efremov L.I. Polipragmaziia: geriatricheskii aspekt problemy. Consilium Medicum. 2007; 9 (12): 29–34. [in Russian]
6. Tikhonoff V, Zhang H, Richart T et al. Blood pressure as a prognostic factor after acute stroke. Lancet Neurol 2009; 8: 938–48.
7. Adams HP, del Zoppo G, Alberts MJ et al. Guidelines for the early management of adults with ischemic stroke. A guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 2007; 38: 1655–711.
8. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension. Blood Press 2014; 23 (1): 3–16. DOI: 10.3109/08037051.2014.868629.HYVET
9. James PA, Oparil S, Carter BL et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth joint national committee (jnc 8). JAMA 2013.
10. The SPRINT Research Group. Randomized trial of intensive versusstandard blood-pressure control. N Engl J Med 2015; 373: 2103–16.
11. Dong C, Della-Morte D, Rundek T et al. Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention The Northern Manhattan Study. Hypertension 2016; 67: 520–6.
12. Micha R, Peñalvo JL, Cudhea F et al. Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States. JAMA 2017; 317 (9): 912–24. DOI: 10.1001/jama.2017.0947
13. Hess G. Medication utilization patterns and hypertension-related expenditures among patients who were switched from fixed-dose to free-combination antihypertensive therapy. PT 2008; 33: 652–66.
14. Zanchetti A, Liu L, Mancia G et al. Stroke in Hypertension Optimal Treatment (SHOT) trial: protocol and organization. J Hypertens 2013; 31 (e-Suppl. A).
15. Jürgens G, Graudal NA. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride. Cochrane Database Syst Rev 2003; 1: CD004022.
16. Cohen HW, Hailpern SM, Fang J, Alderman MH. Sodium intake and mortality in the NHANES II follow-up study. Am J Med 2006; 119 (3): 275.e7–14.
17. Taylor RS, Ashton KE, Moxham T et al. Reduced dietary salt for the prevention of cardiovascular disease: a meta-analysis of randomized controlled trials (Cochrane review). Am J Hypertens 2011; 24 (8): 843–53. DOI: 10.1038/ajh.2011.115
18. Garg R, Williams GH, Hurwitz S et al. Low-salt diet increases insulin resistance in healthy subjects. Metabolism 2011; 60 (7): 965–8. DOI: 10.1016/j.metabol.2010.09.005
19. National Clinical Guideline Centre UK. Hypertension – the clinical management of primary hypertension in adults. August 2011. http://guidance.nice.org.uk/CG127
20. Thoenes M, Neuberger H, Volpe M. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24 (5): 336–44.
21. Beckett NS et al. Treatment of Hypertension in Patients 80 Years of Age or Older. N Engl J Med 2008; 358: 1887–29.
22. Dahlöf B, Sever PS, Poulter NR et al. ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366 (9489): 895–906.
23. Chalmers J, Arima H, Woodward M et al. Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial. Hypertension 2013; 63: 259–64.
24. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dos combinations of antihypertensive agents: a meta-analysis. Hypertension 2010; 55 (2): 399–407.
25. Makani H, Bangalore S, Romero J et al. Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema. Am J Med 2011; 124: 128–35.
26. Лутай М.И. Эффективность комбинированной терапии артериальной гипертензии в Украине: результаты многоцентрового исследования ТРИУМФ. Украинский кардиол. журн. 2016; 4: 17–28. / Lutai M.I. Effektivnost' kombinirovannoi terapii arterial'noi gipertenzii v Ukraine: rezul'taty mnogotsentrovogo issledovaniia TRIUMF. Ukrainskii kardiol. zhurn. 2016; 4: 17–28. [in Russian]
________________________________________________
2. Australian Institute of Health and Welfare (AIHW): Chronic diseases and associated risk factors in Australia, 2006. Canberra: ACT, 2006.
3. Vertkin A.L., Rumiantsev M.A., Skotnikov A.S. Komorbidnost'. Klin. meditsina. 2012; 10: 4–11. [in Russian]
4. Chazova I.E. i dr. Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii. M., 2013. [in Russian]
5. Lazebnik L.B., Konev Iu.V., Drozdov V.N., Efremov L.I. Polipragmaziia: geriatricheskii aspekt problemy. Consilium Medicum. 2007; 9 (12): 29–34. [in Russian]
6. Tikhonoff V, Zhang H, Richart T et al. Blood pressure as a prognostic factor after acute stroke. Lancet Neurol 2009; 8: 938–48.
7. Adams HP, del Zoppo G, Alberts MJ et al. Guidelines for the early management of adults with ischemic stroke. A guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 2007; 38: 1655–711.
8. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension. Blood Press 2014; 23 (1): 3–16. DOI: 10.3109/08037051.2014.868629.HYVET
9. James PA, Oparil S, Carter BL et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth joint national committee (jnc 8). JAMA 2013.
10. The SPRINT Research Group. Randomized trial of intensive versusstandard blood-pressure control. N Engl J Med 2015; 373: 2103–16.
11. Dong C, Della-Morte D, Rundek T et al. Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention The Northern Manhattan Study. Hypertension 2016; 67: 520–6.
12. Micha R, Peñalvo JL, Cudhea F et al. Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States. JAMA 2017; 317 (9): 912–24. DOI: 10.1001/jama.2017.0947
13. Hess G. Medication utilization patterns and hypertension-related expenditures among patients who were switched from fixed-dose to free-combination antihypertensive therapy. PT 2008; 33: 652–66.
14. Zanchetti A, Liu L, Mancia G et al. Stroke in Hypertension Optimal Treatment (SHOT) trial: protocol and organization. J Hypertens 2013; 31 (e-Suppl. A).
15. Jürgens G, Graudal NA. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride. Cochrane Database Syst Rev 2003; 1: CD004022.
16. Cohen HW, Hailpern SM, Fang J, Alderman MH. Sodium intake and mortality in the NHANES II follow-up study. Am J Med 2006; 119 (3): 275.e7–14.
17. Taylor RS, Ashton KE, Moxham T et al. Reduced dietary salt for the prevention of cardiovascular disease: a meta-analysis of randomized controlled trials (Cochrane review). Am J Hypertens 2011; 24 (8): 843–53. DOI: 10.1038/ajh.2011.115
18. Garg R, Williams GH, Hurwitz S et al. Low-salt diet increases insulin resistance in healthy subjects. Metabolism 2011; 60 (7): 965–8. DOI: 10.1016/j.metabol.2010.09.005
19. National Clinical Guideline Centre UK. Hypertension – the clinical management of primary hypertension in adults. August 2011. http://guidance.nice.org.uk/CG127
20. Thoenes M, Neuberger H, Volpe M. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24 (5): 336–44.
21. Beckett NS et al. Treatment of Hypertension in Patients 80 Years of Age or Older. N Engl J Med 2008; 358: 1887–29.
22. Dahlöf B, Sever PS, Poulter NR et al. ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366 (9489): 895–906.
23. Chalmers J, Arima H, Woodward M et al. Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial. Hypertension 2013; 63: 259–64.
24. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dos combinations of antihypertensive agents: a meta-analysis. Hypertension 2010; 55 (2): 399–407.
25. Makani H, Bangalore S, Romero J et al. Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema. Am J Med 2011; 124: 128–35.
26. Lutai M.I. Effektivnost' kombinirovannoi terapii arterial'noi gipertenzii v Ukraine: rezul'taty mnogotsentrovogo issledovaniia TRIUMF. Ukrainskii kardiol. zhurn. 2016; 4: 17–28. [in Russian]
Авторы
И.И.Чукаева*1, Я.Г.Спирякина1, С.Н.Литвинова1, А.В.Штеренгас2, Н.Н.Денисова2
1 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
2 ГБУЗ «Городская клиническая больница №13» Департамента здравоохранения г. Москвы. 115432, Россия, Москва, ул. Трофимова, д. 26
*chukaeva@mail.ru
1 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1;
2 Clinical Hospital №13 of the Department of Health of Moscow. 115432, Russian Federation, Moscow, ul. Trofimova, d. 26
*chukaeva@mail.ru
1 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
2 ГБУЗ «Городская клиническая больница №13» Департамента здравоохранения г. Москвы. 115432, Россия, Москва, ул. Трофимова, д. 26
*chukaeva@mail.ru
________________________________________________
1 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1;
2 Clinical Hospital №13 of the Department of Health of Moscow. 115432, Russian Federation, Moscow, ul. Trofimova, d. 26
*chukaeva@mail.ru
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