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3. Cherry DK, Hing E, Woodwell DA, Rechtsteiner EA. National Ambulatory Medical Care Survey: 2006 Summary. Hyattsville, MD: National Center for Health Statistics; 2008. National health statistics reports.
4. Fendrick AM, Monto AS, Nightengale B et al. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003; 163 (4): 487–94.
5. Козлов Р.С. Селекция резистентных микроорганизмов при использовании антимикробных препаратов: концепция «параллельного ущерба». Клин. микробиол. антимикроб. химиотер. 2010; 12: 284–94. / Kozlov R.S. Selektsiia rezistentnykh mikroorganizmov pri ispol'zovanii antimikrobnykh preparatov: kontseptsiia «parallel'nogo ushcherba». Klin. mikrobiol. antimikrob. khimioter. 2010; 12: 284–94. [in Russian]
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9. Каманин Е.И., Стецюк О.У. Инфекции верхних дыхательных путей и ЛОР-органов. Практическое руководство по антиинфекционной химиотерапии. Под ред. Л.С.Страчунского, Ю.Б.Белоусова, С.Н.Козлова. Смоленск: МАКМАХ, 2007; с. 248–58. / Kamanin E.I., Stetsiuk O.U. Infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii. Pod red. L.S.Strachunskogo, Iu.B.Belousova, S.N.Kozlova. Smolensk: MAKMAKh, 2007; s. 248–58. [in Russian]
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11. Голуб А.В. Пероральные цефалосорины III поколения в амбулаторной клинической практике: современные аспекты применения. Клин. микробиол. антимикроб. химиотер. 2015; 17 (1): 18–23. / Golub A.V. Peroral'nye tsefalosoriny III pokoleniia v ambulatornoi klinicheskoi praktike: sovremennye aspekty primeneniia. Klin. mikrobiol. antimikrob. khimioter. 2015; 17 (1): 18–23. [in Russian]
12. Гуров А.В. Супракс в лечении острой гнойной патологии ЛОР-органов. РМЖ. 2007; 15 (18): 1343–6. / Gurov A.V. Supraks v lechenii ostroi gnoinoi patologii LOR-organov. RMZh. 2007; 15 (18): 1343–6. [in Russian]
13. Носуля Е.В., Ким И.А. Острый риносинусит в амбулаторной практике Consilium Medicum. 2005; 4: 300–5. / Nosulia E.V., Kim I.A. Ostryi rinosinusit v ambulatornoi praktike Consilium Medicum. 2005; 4: 300–5. [in Russian]
14. Antunez C, Blanca Lopez M, Torres MJ. Immediate allergic reactions to cephalosporins evaluationof cros reactivity with a panel of penicillins and cephalosporins. J Allergy Clin Immunol 2006; 117 (2): 404–10.
15. Стратегия и тактика рационального применения антимикробных средств в амбулаторной практике: Евразийские клинические рекомендации. Под ред. С.В.Яковлева, С.В.Сидоренко, В.В.Рафальского, Т.В.Спичак. М.: ПРЕ100ПРИНТ, 2016. / Strategiia i taktika ratsional'nogo primeneniia antimikrobnykh sredstv v ambulatornoi praktike: Evraziiskie klinicheskie rekomendatsii. Pod red. S.V.Iakovleva, S.V.Sidorenko, V.V.Rafal'skogo, T.V.Spichak. M.: PRE100PRINT, 2016. [in Russian]
16. Козлов Р.С., Сивая О.В, Кречикова О.И. и др. Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999–2009 гг. Клин. микробиол. антимикроб. химиотер. 2010; 12: 329–41. / Kozlov R.S., Sivaia O.V, Krechikova O.I. i dr. Dinamika rezistentnosti Streptococcus pneumoniae k antibiotikam v Rossii za period 1999–2009 gg. Klin. mikrobiol. antimikrob. khimioter. 2010; 12: 329–41. [in Russian]
17. Сивая О.В., Козлов Р.С., Кречикова О.И. и др. и группа исследователей проекта ПеГАС. Антибиотикорезистентность Haemophilus influenzae в России: результаты многоцентрового проспективного исследования ПеГАС. Клин. микробиол. антимикроб. химиотер. 2010; 16 (1): 57–69. / Sivaia O.V., Kozlov R.S., Krechikova O.I. i dr. i gruppa issledovatelei proekta PeGAS. Antibiotikorezistentnost' Haemophilus influenzae v Rossii: rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS. Klin. mikrobiol. antimikrob. khimioter. 2010; 16 (1): 57–69. [in Russian]
18. Гучев И.А., Рафальский В.В., Мелехина Е.В. Роль цефиксима в терапии обострения хронической обструктивной болезни легких. Клин. микробиол. антимикроб. химиотер. 2008; 10 (3): 271–89. / Guchev I.A., Rafal'skii V.V., Melekhina E.V. Rol' tsefiksima v terapii obostreniia khronicheskoi obstruktivnoi bolezni legkikh. Klin. mikrobiol. antimikrob. khimioter. 2008; 10 (3): 271–89. [in Russian]
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20. Середа Е.В., Катосова Л.К., Волков И.К. Эффективность цефалоспорина III поколения цефиксима (супракса) при заболеваниях органов дыхания у детей. Лечащий врач. 2004; 1: 30–4. / Sereda E.V., Katosova L.K., Volkov I.K. Effektivnost' tsefalosporina III pokoleniia tsefiksima (supraksa) pri zabolevaniiakh organov dykhaniia u detei. Lechashchii vrach. 2004; 1: 30–4. [in Russian]
21. Карпищенко С.А., Колесникова О.М. Элиминационная терапия в лечении аллергического ринита у детей. Consilium Medicum. Педиатрия. (Прил.) 2014; 4: 28–31. / Karpishchenko S.A., Kolesnikova O.M. Eliminatsionnaia terapiia v lechenii allergicheskogo rinita u detei. Consilium Medicum. Pediatriia. (Pril.) 2014; 4: 28–31. [in Russian]
22. Геппе Н.А., Дронов И.А., Малявина У.С., Афонина Е.Ю. Применение цефиксима для эмпирической терапии внебольничных инфекций дыхательных путей у детей. Педиатрия. 2010; 89: 108–13. / Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 89: 108–13. [in Russian]
23. Harrison CJ, Chartrand SA, Pichichero ME. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 62–9.
24. Gooch WM, Philips A, Rhoades R et al. Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J 1997; 16 (Suppl. 2): 21–4.
25. Геппе Н.А., Дронов И.А., Яблокова Е.А. Цефиксим в лечении инфекций верхних дыхательных путей и ЛОР-органов. Участковый педиатр. 2016; 1: 13. / Geppe N.A., Dronov I.A., Iablokova E.A. Tsefiksim v lechenii infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Uchastkovyi pediatr. 2016; 1: 13. [in Russian]
26. Панякина М.А., Овчинников А.Ю., Мирошниченко Н.А. О целесообразности применения цефиксима для лечения больных острым бактериальным риносинуситом. Фарматека. 2013; 4. / Paniakina M.A., Ovchinnikov A.Iu., Miroshnichenko N.A. O tselesoobraznosti primeneniia tsefiksima dlia lecheniia bol'nykh ostrym bakterial'nym rinosinusitom. Farmateka. 2013; 4. [in Russian]
27. Фокин А.А. Роль цефалоспоринов в терапии внебольничных инфекций нижних и верхних отделов дыхательных путей (на основе данных по чувствительности возбудителей в России). Клин. микробиол. антимикроб. химиотер. 2010; 12 (2): 146–53. / Fokin A.A. Rol' tsefalosporinov v terapii vnebol'nichnykh infektsii nizhnikh i verkhnikh otdelov dykhatel'nykh putei (na osnove dannykh po chuvstvitel'nosti vozbuditelei v Rossii). Klin. mikrobiol. antimikrob. khimioter. 2010; 12 (2): 146–53. [in Russian]
28. Рязанцев С.В. Этиопатогенитическая терапия заболеваний верхних дыхательных путей и уха: методические рекомендации. СПб.: Полифорум Групп, 2015. / Riazantsev S.V. Etiopatogeniticheskaia terapiia zabolevanii verkhnikh dykhatel'nykh putei i ukha: metodicheskie rekomendatsii. SPb.: Poliforum Grupp, 2015. [in Russian]
29. Ludwig E. Cefixime in the Treatment of Respiratory and Urinary Tract Infections. Chemotherapy 1998; 44: 31–4.
30. Dongre N, Ghai H, Kulkarni S et al. Mumbai 400022 Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
31. Радциг Е.Ю., Пивнева Н.Д., Котова Е.Н. и др. Эффективность перорального цефалоспорина III поколения при ЛОР-патологии у детей. Лечащий врач. 2014; 10: 52. / Radtsig E.Iu., Pivneva N.D., Kotova E.N. i dr. Effektivnost' peroral'nogo tsefalosporina III pokoleniia pri LOR-patologii u detei. Lechashchii vrach. 2014; 10: 52. [in Russian]
32. Hausen Th, Weidlich G, Schmitt J. Safety and efficacy of cefixime in the treatment of respiratory tract infections in Germany. Infection 1995; 23 (Suppl. 2): 65–9.
33. Котлуков В.К., Кузьменко Л.Г. Рациональная антибиотикотерапия инфекций дыхательных путей и ЛОР-органов у детей в амбулаторной практике педиатра. Педиатрия. 2008; 87 (6): 110–5. / Kotlukov V.K., Kuz'menko L.G. Ratsional'naia antibiotikoterapiia infektsii dykhatel'nykh putei i LOR-organov u detei v ambulatornoi praktike pediatra. Pediatriia. 2008; 87 (6): 110–5. [in Russian]
34. Dabernat H, Geslin P, Megraud F et al. Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. Antimicrob Chemother J 1998; 41 (2): 253–8.
35. Богомильский М.Р., Балясинская Т.Л., Лазаревич А.А., Ланда Р.И. Значение пероральной антибактериальной терапии в лечении заболеваний ЛОР-органов у детей. Consilium Medicum. 2005; 7 (1): 3–5. / Bogomil'skii M.R., Baliasinskaia T.L., Lazarevich A.A., Landa R.I. Znachenie peroral'noi antibakterial'noi terapii v lechenii zabolevanii LOR-organov u detei. Consilium Medicum. 2005; 7 (1): 3–5. [in Russian]
36. Малявина У.С., Гончарова М.Г., Овчинников А.Ю. Антимикробная терапия острых гнойных средних отитов в педиатрической практике: целесообразность применения цефалоспоринов. Consilium Medicum. Педиатрия. (Прил.) 2007; 1: 30–2. / Maliavina U.S., Goncharova M.G., Ovchinnikov A.Iu. Antimikrobnaia terapiia ostrykh gnoinykh srednikh otitov v pediatricheskoi praktike: tselesoobraznost' primeneniia tsefalosporinov. Pediatrics (Suppl. Consilium Medicum). 2007; 1: 30–2. [in Russian]
37. Rodriguez WJ, Khan W, Sait T et al. Cefixime vs. cefaclor in the treatment of acute otitis media in children: a randomized, comparative study. Pediatr Infect Dis J 1993; 12 (1): 70–4.
38. Leibovitz E, Jacobs MR, Dagan R. Haemophilus influenzae: A significant Pathogen in Acute Otitis Media. Pediatr Infect Dis J 2004; 23 (12): 1142–52.
39. Group ESTG, Pelucchi C, Grigoryan L, Galeone C et al. Guideline for the management of acute sore throat. Clin Microbiol Infect 2012, 18 (Suppl. 1): 1–28.
40. Chiappini E, Regoli M, Bonsignori F et al. Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children. Clin Ther 2011; 33: 48–58.
41. Brook I, Foote PA. Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora. Antimicrob Agents Chemother 2005; 49 (11): 4787–8.
42. Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics 2004; 113 (4): 866–82.
43. Ludwig E, Thege MK, Arr M et al. Resistance of some selected pathogens to antimicrobials in Hungary. Int J Antimicrob Agents 1995; 6 (2): 99–102.
44. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; 23: 1296–310.
45. Яковлев С.В. Современное значение цефалоспоринов при лечении инфекций в стационаре. РМЖ. 2005; 10: 720. / Iakovlev S.V. Sovremennoe znachenie tsefalosporinov pri lechenii infektsii v statsionare. RMZh. 2005; 10: 720. [in Russian]
46. Об изменениях в педиатрическом разделе Российских практических рекомендаций по выбору антибиотиков у детей при инфекциях верхних и нижних дыхательных путей в амбулаторной практике. Педиатрия. 2016; с. 6–9. / Ob izmeneniiakh v pediatricheskom razdele Rossiiskikh prakticheskikh rekomendatsii po vyboru antibiotikov u detei pri infektsiiakh verkhnikh i nizhnikh dykhatel'nykh putei v ambulatornoi praktike. Pediatriia. 2016; s. 6–9. [in Russian]

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1. The first global review and coodination meeting on integrated management of childhood illness (IMCI). http:www.who.int/chd/imcid/report/draft1.htm)
2. Polyakova A.S., Tatochenko V.K. The principles of treatment of acute respiratory viral infections. Consilum Medicum. Pediatrics (Suppl.). 2015; 3: 47–50. [in Russian]
3. Cherry DK, Hing E, Woodwell DA, Rechtsteiner EA. National Ambulatory Medical Care Survey: 2006 Summary. Hyattsville, MD: National Center for Health Statistics; 2008. National health statistics reports.
4. Fendrick AM, Monto AS, Nightengale B et al. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003; 163 (4): 487–94.
5. Kozlov R.S. Selektsiia rezistentnykh mikroorganizmov pri ispol'zovanii antimikrobnykh preparatov: kontseptsiia «parallel'nogo ushcherba». Klin. mikrobiol. antimikrob. khimioter. 2010; 12: 284–94. [in Russian]
6. NICE Short Clinical Guidelines Technical Team (2008). Respiratory tract infections – antibiotic prescribing. Prescribing of antibiotics for self-limiting respiratory tract infections in adults and children in primary care. London: National Institute for Health and Clinical Excellence.
7. Baranov A.A., Tatochenko V.K., Bakradze M.D. Likhoradiashchii rebenok. Protokoly diagnostiki i lecheniia. 2-e izd. M.: Pediatr, 2015. [in Russian]
8. Spurling GKP, Del Mar CB, Dooley L, Foxlee R. Delayed antibiotics for respiratory infections. Cochrane Database System Rev 2013. Art. No.: CD004417.
9. Kamanin E.I., Stetsiuk O.U. Infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii. Pod red. L.S.Strachunskogo, Iu.B.Belousova, S.N.Kozlova. Smolensk: MAKMAKh, 2007; s. 248–58. [in Russian]
10. Belov B.S. Tsefiksim v terapii bakterial'nykh infektsii. RMZh. 2013; 3: 147–53. [in Russian]
11. Golub A.V. Peroral'nye tsefalosoriny III pokoleniia v ambulatornoi klinicheskoi praktike: sovremennye aspekty primeneniia. Klin. mikrobiol. antimikrob. khimioter. 2015; 17 (1): 18–23. [in Russian]
12. Gurov A.V. Supraks v lechenii ostroi gnoinoi patologii LOR-organov. RMZh. 2007; 15 (18): 1343–6. [in Russian]
13. Nosulia E.V., Kim I.A. Ostryi rinosinusit v ambulatornoi praktike Consilium Medicum. 2005; 4: 300–5. [in Russian]
14. Antunez C, Blanca Lopez M, Torres MJ. Immediate allergic reactions to cephalosporins evaluationof cros reactivity with a panel of penicillins and cephalosporins. J Allergy Clin Immunol 2006; 117 (2): 404–10.
15. Strategiia i taktika ratsional'nogo primeneniia antimikrobnykh sredstv v ambulatornoi praktike: Evraziiskie klinicheskie rekomendatsii. Pod red. S.V.Iakovleva, S.V.Sidorenko, V.V.Rafal'skogo, T.V.Spichak. M.: PRE100PRINT, 2016. [in Russian]
16. Kozlov R.S., Sivaia O.V, Krechikova O.I. i dr. Dinamika rezistentnosti Streptococcus pneumoniae k antibiotikam v Rossii za period 1999–2009 gg. Klin. mikrobiol. antimikrob. khimioter. 2010; 12: 329–41. [in Russian]
17. Sivaia O.V., Kozlov R.S., Krechikova O.I. i dr. i gruppa issledovatelei proekta PeGAS. Antibiotikorezistentnost' Haemophilus influenzae v Rossii: rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS. Klin. mikrobiol. antimikrob. khimioter. 2010; 16 (1): 57–69. [in Russian]
18. Guchev I.A., Rafal'skii V.V., Melekhina E.V. Rol' tsefiksima v terapii obostreniia khronicheskoi obstruktivnoi bolezni legkikh. Klin. mikrobiol. antimikrob. khimioter. 2008; 10 (3): 271–89. [in Russian]
19. Hedrick JA. Community-acquired upper respiratory tract infections and the role of third-generation oral cephalosporins. Expert Rev Anti Infect Ther 2010; 8: 15–21.
20. Sereda E.V., Katosova L.K., Volkov I.K. Effektivnost' tsefalosporina III pokoleniia tsefiksima (supraksa) pri zabolevaniiakh organov dykhaniia u detei. Lechashchii vrach. 2004; 1: 30–4. [in Russian]
21. Karpishchenko S.A., Kolesnikova O.M. Eliminatsionnaia terapiia v lechenii allergicheskogo rinita u detei. Consilium Medicum. Pediatriia. (Pril.) 2014; 4: 28–31. [in Russian]
22. Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 89: 108–13. [in Russian]
23. Harrison CJ, Chartrand SA, Pichichero ME. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 62–9.
24. Gooch WM, Philips A, Rhoades R et al. Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J 1997; 16 (Suppl. 2): 21–4.
25. Geppe N.A., Dronov I.A., Iablokova E.A. Tsefiksim v lechenii infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Uchastkovyi pediatr. 2016; 1: 13. [in Russian]
26. Paniakina M.A., Ovchinnikov A.Iu., Miroshnichenko N.A. O tselesoobraznosti primeneniia tsefiksima dlia lecheniia bol'nykh ostrym bakterial'nym rinosinusitom. Farmateka. 2013; 4. [in Russian]
27. Fokin A.A. Rol' tsefalosporinov v terapii vnebol'nichnykh infektsii nizhnikh i verkhnikh otdelov dykhatel'nykh putei (na osnove dannykh po chuvstvitel'nosti vozbuditelei v Rossii). Klin. mikrobiol. antimikrob. khimioter. 2010; 12 (2): 146–53. [in Russian]
28. Riazantsev S.V. Etiopatogeniticheskaia terapiia zabolevanii verkhnikh dykhatel'nykh putei i ukha: metodicheskie rekomendatsii. SPb.: Poliforum Grupp, 2015. [in Russian]
29. Ludwig E. Cefixime in the Treatment of Respiratory and Urinary Tract Infections. Chemotherapy 1998; 44: 31–4.
30. Dongre N, Ghai H, Kulkarni S et al. Mumbai 400022 Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
31. Radtsig E.Iu., Pivneva N.D., Kotova E.N. i dr. Effektivnost' peroral'nogo tsefalosporina III pokoleniia pri LOR-patologii u detei. Lechashchii vrach. 2014; 10: 52. [in Russian]
32. Hausen Th, Weidlich G, Schmitt J. Safety and efficacy of cefixime in the treatment of respiratory tract infections in Germany. Infection 1995; 23 (Suppl. 2): 65–9.
33. Kotlukov V.K., Kuz'menko L.G. Ratsional'naia antibiotikoterapiia infektsii dykhatel'nykh putei i LOR-organov u detei v ambulatornoi praktike pediatra. Pediatriia. 2008; 87 (6): 110–5. [in Russian]
34. Dabernat H, Geslin P, Megraud F et al. Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. Antimicrob Chemother J 1998; 41 (2): 253–8.
35. Bogomil'skii M.R., Baliasinskaia T.L., Lazarevich A.A., Landa R.I. Znachenie peroral'noi antibakterial'noi terapii v lechenii zabolevanii LOR-organov u detei. Consilium Medicum. 2005; 7 (1): 3–5. [in Russian]
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О.А.Егорова*

1 ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России. 214019, Россия, Смоленск, ул. Крупской, д. 28;
2 ОГБУЗ «Смоленская областная клиническая больница». 214018, Россия, Смоленск, пр. Гагарина, д. 27
*ola-egorova@yandex.ru

________________________________________________

O.A.Egorova*

1 Smolensk State Medical University of the Ministry of Health of the Russian Federation. 214019, Russian Federation, Smolensk, ul. Krupskoi, d. 28;
2 Smolensk Regional Clinical Hospital. 214018, Russian Federation, Smolensk, pr. Gagarina, d. 27
*ola-egorova@yandex.ru