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Лечение когнитивных расстройств у больных хронической ишемией мозга
Лечение когнитивных расстройств у больных хронической ишемией мозга
Соловьева Э.Ю. Лечение когнитивных расстройств у больных хронической ишемией мозга. Consilium Medicum. 2017; 19 (2.2. Неврология и Ревматология): 7–12.
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Аннотация
В статье обсуждаются концепция хронической недостаточности церебрального кровообращения, проявляющейся прогрессирующим многоочаговым расстройством функций головного мозга разной степени выраженности, результаты экспериментальных и клинических исследований экстракта гинкго билоба, доказавших возможность препарата быстро и эффективно влиять на различные звенья патогенеза когнитивных нарушений.
Ключевые слова: хроническая ишемия мозга, когнитивные расстройства, память, высшие психические функции.
Key words: chronic cerebral ischemia, cognitive disorders, memory, higher mental functions.
Ключевые слова: хроническая ишемия мозга, когнитивные расстройства, память, высшие психические функции.
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Key words: chronic cerebral ischemia, cognitive disorders, memory, higher mental functions.
Полный текст
Список литературы
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5. Захаров В.В. Умеренные когнитивные расстройства. Диагностика и лечение. Рус. мед. журн. 2006; 14 (9): 685–8. / Zakharov V.V. Umerennye kognitivnye rasstroistva. Diagnostika i lechenie. Rus. med. zhurn. 2006; 14 (9): 685–8. [in Russian]
6. Маньковский Б.Н., Слонимская В.М. Гипертонические энцефалопатии. Врачебное дело. 1959; 7. / Man'kovskii B.N., Slonimskaia V.M. Gipertonicheskie entsefalopatii. Vrachebnoe delo. 1959; 7. [in Russian]
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8. Chui et al. Clinical Criteria for the Diagnosis of Vascular Dementia: A Multicenter Study of Comparability and Interrater Reliability. Arch Neurol 2000; 57: 191–6.
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11. Mairs I, Marocci L, Droy-Lefaix MT et al. Peroxyl radical scavenging activity of Ginkgo biloba extract Egb 761. Biochem Pharmacol 1995; 49: 1649–55.
12. Bridi R, Crossetti FP, Steffen VM et al. The antioxidant activity of standartized extract of Ginkgo biloba (Egb 761) in rats. Phytother Res 2001; 15: 449–51.
13. Pardon MC, Joubert C, Perz-Diaz F et al. In vivo regulation of cerebral monoamine oxidase activity in senescent controls and chronically stressed mice by long-term treatment with Ginkgo biloba extract (EGb 761). Mech Ageing Dev 2000; 13: 157–68.
14. Tchantchou F, Xu Y, Wu Y et al. EGb 761 enhances adult hippocampal neurogenesis and phosphorilation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 2007; 21: 2400–8.
15. Timiras PS. Physiological Basis of Aging and Geriatrics. N.Y.: CRC Press, 2003.
16. Kristofikova Z, Benesova O, Tejkalova H. Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba extract). Dementia 1992; 3: 304–7.
17. Huquet F, Drieu K, Piriou K. Decreased cerebral 5-HT 1a receptors during aging: reversal by Ginkgo biloba extract (Egb 761). J Pharm Pharmacol 1994; 46: 316–8.
18. Williams B, Watanabe C, Schultz P. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiol Aging 2004; 25 (7): 955–62.
19. Stoll S, Scheuer K, Pohl O et al. Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 1996; 29: 144–9.
20. Sun B, Hu Y, Yuan H et al. Extract of Ginkgo biloba promotes the expression of VEGF followed subarachnoid hemorrhage in rats. Int J Neurosci 2009; 119: 995–1005.
21. Yao ZX, Han Z, Drieu K, Papadopoulos VJ. Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels. Nutr Biochem 2004; 15 (12): 749–56.
22. Andrieu S, Ousset PJ, Coley N et al. GuidAge study GROUP. Curr Alzheimer Res 2008; 5 (4): 406–15.
23. Vellas B, Andrieu S, Ousset PJ. Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 2006; 67 (9): S6–S11.
24. DeKosky ST, Fitzpatrick A, Ives DG. The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extracts in prevention of dementia. Contemporary Clinicals Trials 2006; 27: 238–53.
25. LeBars PL, Katz MM, Berman N et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 1997; 278: 1327–32.
2. Vereshchagin N.V., Piradov M.A., Suslina Z.A. Insul't: printsipy diagnostiki, lecheniia i profilaktiki. M.: Intermedika, 2002. [in Russian]
3. Gusev E.I., Skvortsova V.I. Ishemiia golovnogo mozga. M., 2001; s. 45–98. [in Russian]
4. Damulin I.V. Sosudistye kognitivnye narusheniia: klinicheskie i terapevticheskie aspekty. Rus. med. zhurn. 2006; 14 (9): 658–64. [in Russian]
5. Zakharov V.V. Umerennye kognitivnye rasstroistva. Diagnostika i lechenie. Rus. med. zhurn. 2006; 14 (9): 685–8. [in Russian]
6. Man'kovskii B.N., Slonimskaia V.M. Gipertonicheskie entsefalopatii. Vrachebnoe delo. 1959; 7. [in Russian]
7. Skvortsova V.I. Neiroprotektivnaia strategiia ishemicheskogo insul'ta. Vrach. 2004; 6: 26–32. [in Russian]
8. Chui et al. Clinical Criteria for the Diagnosis of Vascular Dementia: A Multicenter Study of Comparability and Interrater Reliability. Arch Neurol 2000; 57: 191–6.
9. Roman GC, Tatemichi TK, Erkinjuntti T et al. Vascular dementia – diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. J Neurology 1993; 43: 250–60.
10. Gupta CM. Phospholipids in disease. In : Phospholipids Handbook, 1993; p. 895–905.
11. Mairs I, Marocci L, Droy-Lefaix MT et al. Peroxyl radical scavenging activity of Ginkgo biloba extract Egb 761. Biochem Pharmacol 1995; 49: 1649–55.
12. Bridi R, Crossetti FP, Steffen VM et al. The antioxidant activity of standartized extract of Ginkgo biloba (Egb 761) in rats. Phytother Res 2001; 15: 449–51.
13. Pardon MC, Joubert C, Perz-Diaz F et al. In vivo regulation of cerebral monoamine oxidase activity in senescent controls and chronically stressed mice by long-term treatment with Ginkgo biloba extract (EGb 761). Mech Ageing Dev 2000; 13: 157–68.
14. Tchantchou F, Xu Y, Wu Y et al. EGb 761 enhances adult hippocampal neurogenesis and phosphorilation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 2007; 21: 2400–8.
15. Timiras PS. Physiological Basis of Aging and Geriatrics. N.Y.: CRC Press, 2003.
16. Kristofikova Z, Benesova O, Tejkalova H. Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba extract). Dementia 1992; 3: 304–7.
17. Huquet F, Drieu K, Piriou K. Decreased cerebral 5-HT 1a receptors during aging: reversal by Ginkgo biloba extract (Egb 761). J Pharm Pharmacol 1994; 46: 316–8.
18. Williams B, Watanabe C, Schultz P. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiol Aging 2004; 25 (7): 955–62.
19. Stoll S, Scheuer K, Pohl O et al. Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 1996; 29: 144–9.
20. Sun B, Hu Y, Yuan H et al. Extract of Ginkgo biloba promotes the expression of VEGF followed subarachnoid hemorrhage in rats. Int J Neurosci 2009; 119: 995–1005.
21. Yao ZX, Han Z, Drieu K, Papadopoulos VJ. Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels. Nutr Biochem 2004; 15 (12): 749–56.
22. Andrieu S, Ousset PJ, Coley N et al. GuidAge study GROUP. Curr Alzheimer Res 2008; 5 (4): 406–15.
23. Vellas B, Andrieu S, Ousset PJ. Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 2006; 67 (9): S6–S11.
24. DeKosky ST, Fitzpatrick A, Ives DG. The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extracts in prevention of dementia. Contemporary Clinicals Trials 2006; 27: 238–53.
25. LeBars PL, Katz MM, Berman N et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 1997; 278: 1327–32.
2. Верещагин Н.В., Пирадов М.А., Суслина З.А. Инсульт: принципы диагностики, лечения и профилактики. М.: Интермедика, 2002. / Vereshchagin N.V., Piradov M.A., Suslina Z.A. Insul't: printsipy diagnostiki, lecheniia i profilaktiki. M.: Intermedika, 2002. [in Russian]
3. Гусев Е.И., Скворцова В.И. Ишемия головного мозга. М., 2001; с. 45–98. / Gusev E.I., Skvortsova V.I. Ishemiia golovnogo mozga. M., 2001; s. 45–98. [in Russian]
4. Дамулин И.В. Сосудистые когнитивные нарушения: клинические и терапевтические аспекты. Рус. мед. журн. 2006; 14 (9): 658–64. / Damulin I.V. Sosudistye kognitivnye narusheniia: klinicheskie i terapevticheskie aspekty. Rus. med. zhurn. 2006; 14 (9): 658–64. [in Russian]
5. Захаров В.В. Умеренные когнитивные расстройства. Диагностика и лечение. Рус. мед. журн. 2006; 14 (9): 685–8. / Zakharov V.V. Umerennye kognitivnye rasstroistva. Diagnostika i lechenie. Rus. med. zhurn. 2006; 14 (9): 685–8. [in Russian]
6. Маньковский Б.Н., Слонимская В.М. Гипертонические энцефалопатии. Врачебное дело. 1959; 7. / Man'kovskii B.N., Slonimskaia V.M. Gipertonicheskie entsefalopatii. Vrachebnoe delo. 1959; 7. [in Russian]
7. Скворцова В.И. Нейропротективная стратегия ишемического инсульта. Врач. 2004; 6: 26–32. / Skvortsova V.I. Neiroprotektivnaia strategiia ishemicheskogo insul'ta. Vrach. 2004; 6: 26–32. [in Russian]
8. Chui et al. Clinical Criteria for the Diagnosis of Vascular Dementia: A Multicenter Study of Comparability and Interrater Reliability. Arch Neurol 2000; 57: 191–6.
9. Roman GC, Tatemichi TK, Erkinjuntti T et al. Vascular dementia – diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. J Neurology 1993; 43: 250–60.
10. Gupta CM. Phospholipids in disease. In : Phospholipids Handbook, 1993; p. 895–905.
11. Mairs I, Marocci L, Droy-Lefaix MT et al. Peroxyl radical scavenging activity of Ginkgo biloba extract Egb 761. Biochem Pharmacol 1995; 49: 1649–55.
12. Bridi R, Crossetti FP, Steffen VM et al. The antioxidant activity of standartized extract of Ginkgo biloba (Egb 761) in rats. Phytother Res 2001; 15: 449–51.
13. Pardon MC, Joubert C, Perz-Diaz F et al. In vivo regulation of cerebral monoamine oxidase activity in senescent controls and chronically stressed mice by long-term treatment with Ginkgo biloba extract (EGb 761). Mech Ageing Dev 2000; 13: 157–68.
14. Tchantchou F, Xu Y, Wu Y et al. EGb 761 enhances adult hippocampal neurogenesis and phosphorilation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 2007; 21: 2400–8.
15. Timiras PS. Physiological Basis of Aging and Geriatrics. N.Y.: CRC Press, 2003.
16. Kristofikova Z, Benesova O, Tejkalova H. Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba extract). Dementia 1992; 3: 304–7.
17. Huquet F, Drieu K, Piriou K. Decreased cerebral 5-HT 1a receptors during aging: reversal by Ginkgo biloba extract (Egb 761). J Pharm Pharmacol 1994; 46: 316–8.
18. Williams B, Watanabe C, Schultz P. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiol Aging 2004; 25 (7): 955–62.
19. Stoll S, Scheuer K, Pohl O et al. Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 1996; 29: 144–9.
20. Sun B, Hu Y, Yuan H et al. Extract of Ginkgo biloba promotes the expression of VEGF followed subarachnoid hemorrhage in rats. Int J Neurosci 2009; 119: 995–1005.
21. Yao ZX, Han Z, Drieu K, Papadopoulos VJ. Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels. Nutr Biochem 2004; 15 (12): 749–56.
22. Andrieu S, Ousset PJ, Coley N et al. GuidAge study GROUP. Curr Alzheimer Res 2008; 5 (4): 406–15.
23. Vellas B, Andrieu S, Ousset PJ. Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 2006; 67 (9): S6–S11.
24. DeKosky ST, Fitzpatrick A, Ives DG. The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extracts in prevention of dementia. Contemporary Clinicals Trials 2006; 27: 238–53.
25. LeBars PL, Katz MM, Berman N et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 1997; 278: 1327–32.
________________________________________________
2. Vereshchagin N.V., Piradov M.A., Suslina Z.A. Insul't: printsipy diagnostiki, lecheniia i profilaktiki. M.: Intermedika, 2002. [in Russian]
3. Gusev E.I., Skvortsova V.I. Ishemiia golovnogo mozga. M., 2001; s. 45–98. [in Russian]
4. Damulin I.V. Sosudistye kognitivnye narusheniia: klinicheskie i terapevticheskie aspekty. Rus. med. zhurn. 2006; 14 (9): 658–64. [in Russian]
5. Zakharov V.V. Umerennye kognitivnye rasstroistva. Diagnostika i lechenie. Rus. med. zhurn. 2006; 14 (9): 685–8. [in Russian]
6. Man'kovskii B.N., Slonimskaia V.M. Gipertonicheskie entsefalopatii. Vrachebnoe delo. 1959; 7. [in Russian]
7. Skvortsova V.I. Neiroprotektivnaia strategiia ishemicheskogo insul'ta. Vrach. 2004; 6: 26–32. [in Russian]
8. Chui et al. Clinical Criteria for the Diagnosis of Vascular Dementia: A Multicenter Study of Comparability and Interrater Reliability. Arch Neurol 2000; 57: 191–6.
9. Roman GC, Tatemichi TK, Erkinjuntti T et al. Vascular dementia – diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. J Neurology 1993; 43: 250–60.
10. Gupta CM. Phospholipids in disease. In : Phospholipids Handbook, 1993; p. 895–905.
11. Mairs I, Marocci L, Droy-Lefaix MT et al. Peroxyl radical scavenging activity of Ginkgo biloba extract Egb 761. Biochem Pharmacol 1995; 49: 1649–55.
12. Bridi R, Crossetti FP, Steffen VM et al. The antioxidant activity of standartized extract of Ginkgo biloba (Egb 761) in rats. Phytother Res 2001; 15: 449–51.
13. Pardon MC, Joubert C, Perz-Diaz F et al. In vivo regulation of cerebral monoamine oxidase activity in senescent controls and chronically stressed mice by long-term treatment with Ginkgo biloba extract (EGb 761). Mech Ageing Dev 2000; 13: 157–68.
14. Tchantchou F, Xu Y, Wu Y et al. EGb 761 enhances adult hippocampal neurogenesis and phosphorilation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 2007; 21: 2400–8.
15. Timiras PS. Physiological Basis of Aging and Geriatrics. N.Y.: CRC Press, 2003.
16. Kristofikova Z, Benesova O, Tejkalova H. Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba extract). Dementia 1992; 3: 304–7.
17. Huquet F, Drieu K, Piriou K. Decreased cerebral 5-HT 1a receptors during aging: reversal by Ginkgo biloba extract (Egb 761). J Pharm Pharmacol 1994; 46: 316–8.
18. Williams B, Watanabe C, Schultz P. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiol Aging 2004; 25 (7): 955–62.
19. Stoll S, Scheuer K, Pohl O et al. Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 1996; 29: 144–9.
20. Sun B, Hu Y, Yuan H et al. Extract of Ginkgo biloba promotes the expression of VEGF followed subarachnoid hemorrhage in rats. Int J Neurosci 2009; 119: 995–1005.
21. Yao ZX, Han Z, Drieu K, Papadopoulos VJ. Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels. Nutr Biochem 2004; 15 (12): 749–56.
22. Andrieu S, Ousset PJ, Coley N et al. GuidAge study GROUP. Curr Alzheimer Res 2008; 5 (4): 406–15.
23. Vellas B, Andrieu S, Ousset PJ. Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 2006; 67 (9): S6–S11.
24. DeKosky ST, Fitzpatrick A, Ives DG. The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extracts in prevention of dementia. Contemporary Clinicals Trials 2006; 27: 238–53.
25. LeBars PL, Katz MM, Berman N et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 1997; 278: 1327–32.
Авторы
Э.Ю.Соловьева
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
ellasolovieva@ya.ru
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
ellasolovieva@ya.ru
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
ellasolovieva@ya.ru
________________________________________________
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
ellasolovieva@ya.ru
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