1. Van Hecke O, Torrance N, Smith BH. Chronic pain epidemiology and its clinical relevance. Br J Anaesth 2013; 1: 13–8.
2. Oren O, Ablin J. Precision medicine: the emerging approach to the chronic pain patient. Int J Clin Rheumtol 2013; 4: 491–9.
3. Пилипович А.А. Боль в спине и суставах. Новая аптека. 2010; 11: 18. / Pilipovich A.A. Bol' v spine i sustavakh. Novaia apteka. 2010; 11: 18. [in Russian]
4. Dieppe P. Chronic musculoskeletal pain. BMJ 2013; 346 (6): f3146.
5. Пилипович А.А. Миофасциальный болевой синдром. Новая аптека. 2011; 9: 68. / Pilipovich A.A. Miofastsial'nyi bolevoi sindrom. Novaia apteka. 2011; 9: 68. [in Russian]
6. Хайне Х. Иммунологическая воспалительная реакция, вызванная антигомотоксической терапией воспалительных заболеваний суставов. Биологическая медицина. 1999; 1: 5–8. / Khaine Kh. Immunologicheskaia vospalitel'naia reaktsiia, vyzvannaia antigomotoksicheskoi terapiei vospalitel'nykh zabolevanii sustavov. Biologicheskaia meditsina. 1999; 1: 5–8. [in Russian]
7. Пилипович А.А. Хроническая боль при заболеваниях опорно-двигательного аппарата: применение антигомотоксических препаратов. Consilium Medicum. 2016; 18 (9): 128–32. / Pilipovich A.A. Chronic pain in diseases of the musculoskeletal system: the use of antihomotoxic medications. Consilium Medicum. 2016; 18 (9): 128–32. [in Russian]
8. Van Haselen R. An Integrative Review of the Evidence on the Antihomotoxic Medication Traumeel. 1–29.
9. Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. CEBM Web site. http://www.cebm.net/wp-content/uploads/2014/06/CEBM-Levels-of-Evidence-2.1.pdf.
10. Schneider C. Traumeel: an emerging option to nonsteroidal anti-inflammatory drugs in the management of acute musculoskeletal injuries. Int J Gen Med 2011; 4: 225–34.
11. Müller-Löbnitz C, Göthel D. Review of the clinical efficacy of the multicomponent combination medication Traumeel and its components. Altern Ther Health Med 2011; 17 (Suppl. 2): s18–s31.
12. Speed C, Wolfarth B. Challenges of pain masking in the management of soft tissue disorders: optimizing patient outcomes with a multi-targeted approach. Curr Med Res Opin 2014; 30 (5): 953–9.
13. Conforti A, Bertani S, Metelmann H et al. Experimental studies on the anti-inflammatory activity of a homeopathic preparation. Biomed Ther 1997; 15 (1): 28–31.
14. Conforti A, Bertani S, Lussignoli S, Bellavite P. Wirkungen Antihomotoxischer Präparate auf akute und chronische Entzündungen. Biol Medizin 1998; 27 (2): 63–6.
15. Enbergs H. The effect of selected potentiated suis organ preparations and Traumeel on phagocyte and lymphocyte activity. Biomed Ther 1998; 16 (2):178–85.
16. Lussignoli S, Bertani S, Metelmann H et al. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complement Ther Med 1999; 7 (4): 225–30.
17. Heine H, Andrä F. On the anti-inflammatory mechanism of action of an antihomotoxic compound remedy [in German]. Ärztezeitschriftfür Naturheilverfahren 2002; 43 (2): 96–104.
18. Porozov S, Cahalon L, Weiser M et al. Inhibition of IL-1b and TNF-a secretion from resting and activated human immunocytes by the homeopathic medication Traumeel® S. Clin Dev Immunol 2004; 11 (2): 143–9.
19. Seilheimer B, Wierzchacz C, Gebhardt R. Influence of Traumeel on cultured chondrocytes and recombinant human matrix metalloproteinases: implications for chronic joint diseases. Eur J Integr Med 2009; 1 (4): 252–3.
20. St Laurent G, Tackett M, McCaffrey T, Kapranov P. Deep sequencing transcriptome analysis of Traumeel therapeutic action in wound healing (THU0016). Ann Rheum Dis 2013; 72 (Suppl. 3).
21. Zell J, Connert WD, Mau J, Feuerstake G. Behandlung von Sprunggelenksdistorsionen: Doppelblindstudie zum Wirksamkeitsnachweis eines homöopathischen Salbenpräparats. Fortschr Med 1988; 106 (5): 96–100.
22. Zell J, Connert WD, Mau J, Feuerstake G. Treatment of acute sprains of the ankle: a controlled double-blind trial to test the effectiveness of a homeopathic ointment. Biol Ther 1989; 7 (1): 1–6.
23. Thiel W, Borho B. Posttraumatische Kniegelenksergüsse und intraartikuläre Traumeel-N-Injektion. Orthopädische Prax 1991; 27 (11): 721–5.
24. Thiel W, Borho B. The treatment of recent traumatic blood effusions of the knee joint. Biol Ther 1994; 12 (4): 242–8.
25. Böhmer D, Ambrus P. Treatment of sports injuries with Traumeel ointment: a controlled double-blind study. Biol Ther 1992; 10 (4): 290–300.
26. Arora S, Harris T, Scherer C. Clinical safety of a homeopathic preparation. Biomed Ther 2000; 18 (2): 222–5.
27. González de Vega C, Speed C, Wolfarth B, González J. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial. Int J Clin Pract 2013; 67 (10): 979–89.
28. González de Vega C, Gonzáles J. A randomized, controlled, multicenter study on the effectiveness of Traumeel (ointment and gel) in terms of pain reduction and function improvement compared with diclofenac gel in acute ankle sprain. Ann Rheum Dis 2012; 71 (Suppl. 3): SAT0423.
29. Lozada C, del Rio E, Reitberg D et al. A multi-center double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections versus IA placebo in patients with moderate-to-severe pain associated with OA of the knee. Arthritis Rheum 2014; 66 (Suppl): S1266.
30. Lozada C, del Rio E, Reitberg DP et al. Risk-benefit of co-administered Traumeel® (Tr14) and ZeelR (Ze14) intra-articular (IA) injections in patients with moderate-to-severe pain associated with OA of the knee (OAK) (THU0441). Ann Rheum Dis 2015; 74 (Suppl. 2): 4268.
31. Zenner S, Metelmann H. Application possibilities of Traumeel S injection solution: Results of a multicentric drug monitoring trial conducted on 3,241 patients. Biol Ther 1992; 10 (4): 301–10.
32. Zenner S, Metelmann H. Therapy experiences with a homeopathic ointment: Results of drug surveillance conducted on 3,422 patients. Biol Ther 1994; 12 (3): 204–11.
33. Weiser M, Zenner S. Orale Therapie traumatischer, entzündlicher und degenerativer Affektionen mit einem Homöopathikum. Biol Medizin 1996; 25 (5): 211–16.
34. Zenner S, Weiser M. Oral treatment of traumatic, inflammatory, and degenerative conditions with a homeopathic remedy. Biomed Ther 1997; 15 (1): 22–6.
35. Ludwig J, Weiser M. Treating pediatric trauma with a homeopathic ointment. J Biomed Ther 2001; 2: 8–11.
36. Birnesser H, Oberbaum M, Klein P, Weiser M. The homeopathic preparation Traumeel S compared with NSAIDs for symptomatic treatment of epicondylitis. J Musculoskelet Res 2004; 8 (2 & 3): 119–28.
37. Schneider C, Klein P, Stolt P, Oberbaum M. A homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathy. Explore (NY). 2005; 1 (6): 446–52.
38. Schneider C, Schneider B, Hanisch J, van Haselen R. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med 2008; 16 (1): 22–7.

________________________________________________

1. Van Hecke O, Torrance N, Smith BH. Chronic pain epidemiology and its clinical relevance. Br J Anaesth 2013; 1: 13–8.
2. Oren O, Ablin J. Precision medicine: the emerging approach to the chronic pain patient. Int J Clin Rheumtol 2013; 4: 491–9.
3. Pilipovich A.A. Bol' v spine i sustavakh. Novaia apteka. 2010; 11: 18. [in Russian]
4. Dieppe P. Chronic musculoskeletal pain. BMJ 2013; 346 (6): f3146.
5. Pilipovich A.A. Miofastsial'nyi bolevoi sindrom. Novaia apteka. 2011; 9: 68. [in Russian]
6. Khaine Kh. Immunologicheskaia vospalitel'naia reaktsiia, vyzvannaia antigomotoksicheskoi terapiei vospalitel'nykh zabolevanii sustavov. Biologicheskaia meditsina. 1999; 1: 5–8. [in Russian]
7. Pilipovich A.A. Chronic pain in diseases of the musculoskeletal system: the use of antihomotoxic medications. Consilium Medicum. 2016; 18 (9): 128–32. [in Russian]
8. Van Haselen R. An Integrative Review of the Evidence on the Antihomotoxic Medication Traumeel. 1–29.
9. Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. CEBM Web site. http://www.cebm.net/wp-content/uploads/2014/06/CEBM-Levels-of-Evidence-2.1.pdf.
10. Schneider C. Traumeel: an emerging option to nonsteroidal anti-inflammatory drugs in the management of acute musculoskeletal injuries. Int J Gen Med 2011; 4: 225–34.
11. Müller-Löbnitz C, Göthel D. Review of the clinical efficacy of the multicomponent combination medication Traumeel and its components. Altern Ther Health Med 2011; 17 (Suppl. 2): s18–s31.
12. Speed C, Wolfarth B. Challenges of pain masking in the management of soft tissue disorders: optimizing patient outcomes with a multi-targeted approach. Curr Med Res Opin 2014; 30 (5): 953–9.
13. Conforti A, Bertani S, Metelmann H et al. Experimental studies on the anti-inflammatory activity of a homeopathic preparation. Biomed Ther 1997; 15 (1): 28–31.
14. Conforti A, Bertani S, Lussignoli S, Bellavite P. Wirkungen Antihomotoxischer Präparate auf akute und chronische Entzündungen. Biol Medizin 1998; 27 (2): 63–6.
15. Enbergs H. The effect of selected potentiated suis organ preparations and Traumeel on phagocyte and lymphocyte activity. Biomed Ther 1998; 16 (2):178–85.
16. Lussignoli S, Bertani S, Metelmann H et al. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complement Ther Med 1999; 7 (4): 225–30.
17. Heine H, Andrä F. On the anti-inflammatory mechanism of action of an antihomotoxic compound remedy [in German]. Ärztezeitschriftfür Naturheilverfahren 2002; 43 (2): 96–104.
18. Porozov S, Cahalon L, Weiser M et al. Inhibition of IL-1b and TNF-a secretion from resting and activated human immunocytes by the homeopathic medication Traumeel® S. Clin Dev Immunol 2004; 11 (2): 143–9.
19. Seilheimer B, Wierzchacz C, Gebhardt R. Influence of Traumeel on cultured chondrocytes and recombinant human matrix metalloproteinases: implications for chronic joint diseases. Eur J Integr Med 2009; 1 (4): 252–3.
20. St Laurent G, Tackett M, McCaffrey T, Kapranov P. Deep sequencing transcriptome analysis of Traumeel therapeutic action in wound healing (THU0016). Ann Rheum Dis 2013; 72 (Suppl. 3).
21. Zell J, Connert WD, Mau J, Feuerstake G. Behandlung von Sprunggelenksdistorsionen: Doppelblindstudie zum Wirksamkeitsnachweis eines homöopathischen Salbenpräparats. Fortschr Med 1988; 106 (5): 96–100.
22. Zell J, Connert WD, Mau J, Feuerstake G. Treatment of acute sprains of the ankle: a controlled double-blind trial to test the effectiveness of a homeopathic ointment. Biol Ther 1989; 7 (1): 1–6.
23. Thiel W, Borho B. Posttraumatische Kniegelenksergüsse und intraartikuläre Traumeel-N-Injektion. Orthopädische Prax 1991; 27 (11): 721–5.
24. Thiel W, Borho B. The treatment of recent traumatic blood effusions of the knee joint. Biol Ther 1994; 12 (4): 242–8.
25. Böhmer D, Ambrus P. Treatment of sports injuries with Traumeel ointment: a controlled double-blind study. Biol Ther 1992; 10 (4): 290–300.
26. Arora S, Harris T, Scherer C. Clinical safety of a homeopathic preparation. Biomed Ther 2000; 18 (2): 222–5.
27. González de Vega C, Speed C, Wolfarth B, González J. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial. Int J Clin Pract 2013; 67 (10): 979–89.
28. González de Vega C, Gonzáles J. A randomized, controlled, multicenter study on the effectiveness of Traumeel (ointment and gel) in terms of pain reduction and function improvement compared with diclofenac gel in acute ankle sprain. Ann Rheum Dis 2012; 71 (Suppl. 3): SAT0423.
29. Lozada C, del Rio E, Reitberg D et al. A multi-center double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections versus IA placebo in patients with moderate-to-severe pain associated with OA of the knee. Arthritis Rheum 2014; 66 (Suppl): S1266.
30. Lozada C, del Rio E, Reitberg DP et al. Risk-benefit of co-administered Traumeel® (Tr14) and ZeelR (Ze14) intra-articular (IA) injections in patients with moderate-to-severe pain associated with OA of the knee (OAK) (THU0441). Ann Rheum Dis 2015; 74 (Suppl. 2): 4268.
31. Zenner S, Metelmann H. Application possibilities of Traumeel S injection solution: Results of a multicentric drug monitoring trial conducted on 3,241 patients. Biol Ther 1992; 10 (4): 301–10.
32. Zenner S, Metelmann H. Therapy experiences with a homeopathic ointment: Results of drug surveillance conducted on 3,422 patients. Biol Ther 1994; 12 (3): 204–11.
33. Weiser M, Zenner S. Orale Therapie traumatischer, entzündlicher und degenerativer Affektionen mit einem Homöopathikum. Biol Medizin 1996; 25 (5): 211–16.
34. Zenner S, Weiser M. Oral treatment of traumatic, inflammatory, and degenerative conditions with a homeopathic remedy. Biomed Ther 1997; 15 (1): 22–6.
35. Ludwig J, Weiser M. Treating pediatric trauma with a homeopathic ointment. J Biomed Ther 2001; 2: 8–11.
36. Birnesser H, Oberbaum M, Klein P, Weiser M. The homeopathic preparation Traumeel S compared with NSAIDs for symptomatic treatment of epicondylitis. J Musculoskelet Res 2004; 8 (2 & 3): 119–28.
37. Schneider C, Klein P, Stolt P, Oberbaum M. A homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathy. Explore (NY). 2005; 1 (6): 446–52.
38. Schneider C, Schneider B, Hanisch J, van Haselen R. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med 2008; 16 (1): 22–7.

А.А.Пилипович

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
aapilipovich@mail.ru

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