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Геморрагический цистит у женщин: эпидемиология, этиология, патогенез, диагностика
Геморрагический цистит у женщин: эпидемиология, этиология, патогенез, диагностика
Лоран О.Б., Синякова Л.А., Незовибатько Я.И. Геморрагический цистит у женщин: эпидемиология, этиология, патогенез, диагностика. Consilium Medicum. 2017; 19 (7): 50–55. DOI: 10.26442/2075-1753_19.7.50-55
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Аннотация
Геморрагический цистит (ГЦ) в структуре воспалительных заболеваний нижних мочевых путей составляет от 5 до 10%, в последнее время наметилась тенденция увеличения числа больных с указанным заболеванием. ГЦ может являться осложнением противоопухолевой химио- или лучевой терапии у пациентов со злокачественными опухолями органов малого таза. Однако наиболее часто ГЦ возникает у женщин, страдающих хронической герпес-вирусной инфекцией. Учитывая многообразие этиологических факторов, приводящих к возникновению ГЦ, имеют место различные патофизиологические механизмы развития заболевания, что требует индивидуального подхода, разработки алгоритмов обследования и ведения указанных пациентов. Статья включает обзор зарубежных и отечественных научных публикаций, посвященных эпидемиологии, этиологии, патогенезу и диагностике ГЦ.
Ключевые слова: геморрагический цистит, лучевая терапия, химиотерапия, циклофосфамид, полиомавирусы, вирус простого герпеса 1 и 2-го типа.
Key words: hemorrhagic cystitis, radiation therapy, chemotherapy, cyclophosphamide, polyomaviruses, herpes simplex virus type 1 and type 2.
Ключевые слова: геморрагический цистит, лучевая терапия, химиотерапия, циклофосфамид, полиомавирусы, вирус простого герпеса 1 и 2-го типа.
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Key words: hemorrhagic cystitis, radiation therapy, chemotherapy, cyclophosphamide, polyomaviruses, herpes simplex virus type 1 and type 2.
Полный текст
Список литературы
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12. Islam R, Issacson BJ, Zickerman PM et al. Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: Case report. Am J Clin Oncol 2002; 25: 513–4.
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14. Andriole GL, Brickman C, Lack EE et al. Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. J Urol 1986; 135 (1): 44–6.
15. Naber KG et al. Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur Urol 2008; 54 (5): 1164–75.
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23. Mylonakis E, Goes N, Rubin RH et al. BK virus in solid organ transplant recipients: an emerging syndrome. Transplantation 2001; 72 (10): 1587–92.
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25. Haines HL, Laskin BL, Goebel J et al. Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17 (10): 1512–9.
26. Hoffman JA, Shah AJ, Ross LA, Kapoor N. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7 (7): 388–94.
27. Hofland CA, Eron LJ, Washecka RM. Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc 2004; 36 (10): 3025–7.
28. Ison MG. Adenovirus infections in transplant recipients. Clin Infect Dis 2006; 43 (3): 331–9.
29. Spach DH, Bauwens JE, Myerson D et al. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993; 16 (1): 142–4.
30. Tutuncuoglu SO, Yanovich S, Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant 2005; 36 (3): 265–6.
31. Focosi D, Kast RE. Hyaluronate and risperidone for hemorrhagic cystitis. Bone Marrow Transplant 2007; 39 (1): 57.
32. McClanahan C, Grimes MM, Callaghan E, Stewart J. Hemorrhagic cystitis associated with herpes simplex virus. J Urol 1994; 151 (1): 152–3.
33. Nguyen ML, Borochovitz D, Thomas G et al. Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa. Clin Infect Dis 1992; 14 (3): 767–8.
34. Uhm J, Hamad N, Michelis FV et al. The risk of polyomavirus BK-associated hemorrhagic cystitis after allogeneic hematopoietic SCT is associated with myeloablative conditioning, CMV viremia and severe acute GVHD. Bone Marrow Transplant 2014; 49 (12).
35. Lunde LE, Dasaraju S, Cao Q et al. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant 2015; 13.
36. Gorczynska E, Turkiewicz D, Rybka K et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2005; 11 (10): 797–804.
37. Smit SG, Heyns CF. Management of radiation cystitis. Nat Rev Urol 2010; 7: 206–14.
38. Payne H, Adamson A, Bahl A et al. Chemical and radiation induced haemorrhagic cystitis: current treatments and challenges. BJU Int 2013; 112: 885–97.
39. Corman JM, McClure D, Pritchett R et al. Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen. J Urol 2003; 169 (6): 2200–2.
40. Zwaans BM, Chancellor MB, Lamb LE. Modeling and treatment of radiation cystitis. Urology 2015; DOI: 10.1016/j.urology.2015.11.001
41. Schoenike SE, Dana WJ. Ifosfamide and mesna. Clin Pharm 1990; 9: 179–91.
42. Ribeiro RA, Freitas HC, Campos MC et al. Tumor necrosis factor-alpha and interleukin-1 beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol 2002; 167: 2229–34.
43. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007; 23: 303–12.
44. Gomes TN, Santos CC, Souza-Filho MV et al. Participation of TNF-alpha and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Braz J Med Biol Res 1995; 28: 1103–8.
45. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996; 271: 1424–37.
46. Kimura M, Tomita Y, Morishita H, Takahashi K. Presence of mucosal change in the urinary bladder in non hematuria patients with long-term exposure and/or accumulating high-dose cyclophosohamide. Possible significance of follow-up cystoscopy on preventing development of cyclophosphamide-induced hemorrhagic cystitis. Urol Int 1998; 61: 8–11.
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51. Talar-Williams C, Hijazi YM, Walther MM et al. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener′s granulomatosis. Ann Intern Med 1996; 124: 477–84.
52. Droller MJ, Saral R, Santos G. Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 1982; 20: 256–8.
53. Radcliffe K, European STD Guidelines, 2004.
54. Paduch DA. Viral lower urinary tract infections. Curr Urol Rep 2007; 8: 324–35.
55. Zaleska-Dorobisz U, Biel A, Sokołowska-Dąbek D et al. Ultrasonography in the diagnosis of hemorrhagic cystitis – a complication of bone marrow transplantation in pediatric oncology patients. J Ultrason 2014; 14 (58): 258–72.
56. Epstein J, Reuter V, Amin M. Biopsy Interpretation of the Bladder. 2nd edition, 2011.
2. Manikandan R, Kumar S, Lalgudi N. Dorairajan, Hemorrhagic cystitis: A challenge to the urologist. Indian J Urol 2010; 26 (2): 159–66.
3. Basler J, Kim E. Hemorrhagic Cystitis. Medscape, 2016.
4. Crew JP, Jephcott CR, Reynard JM. Radiation-induced haemorrhagic cystitis. Eur Urol 2001; 40 (2): 111–23.
5. Chong KT, Hampson NB, Corman JM. Early hyperbaric therapy improves outcome for radiation-induced hemorrhagic cystitis. Urology 2005; 65: 649–53.
6. Liem X, Saad F, Delouya G. A Practical Approach to the Management of Radiation-Induced Hemorrhagic Cystitis. Drugs 2015; 75 (13): 1471–82.
7. Boyle P, Levin B. World cancer report. Lyon: IARC Press, 2008.
8. Denton AS, Clarke N, Maher J. Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis. Cochrane Database Syst Rev 2002; CD001773.
9. Levenback C, Eifel PJ, Burke TW et al. Hemorrhagic cystitis following radiotherapy for stage Ib cancer of the cervix. Gynecol Oncol 1994; 55 (2): 206–10.
10. Palou J, Pisano F, Esquena S et al. Natural history and predictive factors for hospitalization in patients with radiation cystitis. Results from a large retrospective study. J Urol 2016; 195 (Suppl. 4): e956–e957.
11. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007; 23: 303–12.
12. Islam R, Issacson BJ, Zickerman PM et al. Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: Case report. Am J Clin Oncol 2002; 25: 513–4.
13. Marx CM, Alpert SE. Ticarcillin-induced cystitis. Cross reactivity with related pencillin. Am J Dis Child 1984; 138: 670–2.
14. Andriole GL, Brickman C, Lack EE et al. Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. J Urol 1986; 135 (1): 44–6.
15. Naber KG et al. Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur Urol 2008; 54 (5): 1164–75.
16. Naber K, Scaeffer A, Heyns C et al. Urogenital Infections. 2010.
17. Erard V, Storer B, Corey L et al. BK virus infection in haematopoietic stem cell transplant receipents: Frequency, risk factors and association with post engraftment haemorrhagic cystitis. Clin Infect Dis 2004; 39: 1861–5.
18. Azzi A, Ciappi S, De Santis R et al. Hemorrhagic cystitis associated with BKV in patients with refractory acute lymphoblastic leukemia. Am J Hematol 1996; 52 (2): 121–2.
19. Azzi A, Fanci R, Bosi A et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorrhagic cystitis. Bone Marrow Transplant 1994; 14 (2): 235–40.
20. Bedi A, Miller CB, Hanson JL et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995; 13 (5): 1103–9.
21. Erard V, Kim HW, Corey L et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 2005; 106 (3): 1130–2.
22. Giraud G, Bogdanovic G, Priftakis P et al. The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen. Haematologica 2006; 91 (3): 401–4.
23. Mylonakis E, Goes N, Rubin RH et al. BK virus in solid organ transplant recipients: an emerging syndrome. Transplantation 2001; 72 (10): 1587–92.
24. Mori Y, Miyamoto T, Kato K et al. Different risk factors related to adenovirus or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2011; 31.
25. Haines HL, Laskin BL, Goebel J et al. Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17 (10): 1512–9.
26. Hoffman JA, Shah AJ, Ross LA, Kapoor N. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7 (7): 388–94.
27. Hofland CA, Eron LJ, Washecka RM. Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc 2004; 36 (10): 3025–7.
28. Ison MG. Adenovirus infections in transplant recipients. Clin Infect Dis 2006; 43 (3): 331–9.
29. Spach DH, Bauwens JE, Myerson D et al. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993; 16 (1): 142–4.
30. Tutuncuoglu SO, Yanovich S, Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant 2005; 36 (3): 265–6.
31. Focosi D, Kast RE. Hyaluronate and risperidone for hemorrhagic cystitis. Bone Marrow Transplant 2007; 39 (1): 57.
32. McClanahan C, Grimes MM, Callaghan E, Stewart J. Hemorrhagic cystitis associated with herpes simplex virus. J Urol 1994; 151 (1): 152–3.
33. Nguyen ML, Borochovitz D, Thomas G et al. Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa. Clin Infect Dis 1992; 14 (3): 767–8.
34. Uhm J, Hamad N, Michelis FV et al. The risk of polyomavirus BK-associated hemorrhagic cystitis after allogeneic hematopoietic SCT is associated with myeloablative conditioning, CMV viremia and severe acute GVHD. Bone Marrow Transplant 2014; 49 (12).
35. Lunde LE, Dasaraju S, Cao Q et al. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant 2015; 13.
36. Gorczynska E, Turkiewicz D, Rybka K et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2005; 11 (10): 797–804.
37. Smit SG, Heyns CF. Management of radiation cystitis. Nat Rev Urol 2010; 7: 206–14.
38. Payne H, Adamson A, Bahl A et al. Chemical and radiation induced haemorrhagic cystitis: current treatments and challenges. BJU Int 2013; 112: 885–97.
39. Corman JM, McClure D, Pritchett R et al. Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen. J Urol 2003; 169 (6): 2200–2.
40. Zwaans BM, Chancellor MB, Lamb LE. Modeling and treatment of radiation cystitis. Urology 2015; DOI: 10.1016/j.urology.2015.11.001
41. Schoenike SE, Dana WJ. Ifosfamide and mesna. Clin Pharm 1990; 9: 179–91.
42. Ribeiro RA, Freitas HC, Campos MC et al. Tumor necrosis factor-alpha and interleukin-1 beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol 2002; 167: 2229–34.
43. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007; 23: 303–12.
44. Gomes TN, Santos CC, Souza-Filho MV et al. Participation of TNF-alpha and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Braz J Med Biol Res 1995; 28: 1103–8.
45. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996; 271: 1424–37.
46. Kimura M, Tomita Y, Morishita H, Takahashi K. Presence of mucosal change in the urinary bladder in non hematuria patients with long-term exposure and/or accumulating high-dose cyclophosohamide. Possible significance of follow-up cystoscopy on preventing development of cyclophosphamide-induced hemorrhagic cystitis. Urol Int 1998; 61: 8–11.
47. Krane DM, Levine LA. Hemorrhagic cystitis. AUA Update Series 1992; XI: Lesson 31.
48. Amvros'eva T.V., Dediulia K.L., Poklonskaia N.V., Bogush Z.F. Poliomavirusnaia infektsiia cheloveka: znachenie v patologii i genodiagnostika. Zdravookhranenie. 2014; 10. [in Russian]
49. Skriabin G.N., Aleksandrov V.P., Koren'kov D.G., Nazarov T.N. Tsistity. Uchebn. posobie. SPb., 2006. [in Russian]
50. Isakov V.A., Arkhipova E.I., Isakov D.V. Gerpesvirusnye infektsii cheloveka. 2011. [in Russian]
51. Talar-Williams C, Hijazi YM, Walther MM et al. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener′s granulomatosis. Ann Intern Med 1996; 124: 477–84.
52. Droller MJ, Saral R, Santos G. Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 1982; 20: 256–8.
53. Radcliffe K, European STD Guidelines, 2004.
54. Paduch DA. Viral lower urinary tract infections. Curr Urol Rep 2007; 8: 324–35.
55. Zaleska-Dorobisz U, Biel A, Sokołowska-Dąbek D et al. Ultrasonography in the diagnosis of hemorrhagic cystitis – a complication of bone marrow transplantation in pediatric oncology patients. J Ultrason 2014; 14 (58): 258–72.
56. Epstein J, Reuter V, Amin M. Biopsy Interpretation of the Bladder. 2nd edition, 2011.
2. Manikandan R, Kumar S, Lalgudi N. Dorairajan, Hemorrhagic cystitis: A challenge to the urologist. Indian J Urol 2010; 26 (2): 159–66.
3. Basler J, Kim E. Hemorrhagic Cystitis. Medscape, 2016.
4. Crew JP, Jephcott CR, Reynard JM. Radiation-induced haemorrhagic cystitis. Eur Urol 2001; 40 (2): 111–23.
5. Chong KT, Hampson NB, Corman JM. Early hyperbaric therapy improves outcome for radiation-induced hemorrhagic cystitis. Urology 2005; 65: 649–53.
6. Liem X, Saad F, Delouya G. A Practical Approach to the Management of Radiation-Induced Hemorrhagic Cystitis. Drugs 2015; 75 (13): 1471–82.
7. Boyle P, Levin B. World cancer report. Lyon: IARC Press, 2008.
8. Denton AS, Clarke N, Maher J. Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis. Cochrane Database Syst Rev 2002; CD001773.
9. Levenback C, Eifel PJ, Burke TW et al. Hemorrhagic cystitis following radiotherapy for stage Ib cancer of the cervix. Gynecol Oncol 1994; 55 (2): 206–10.
10. Palou J, Pisano F, Esquena S et al. Natural history and predictive factors for hospitalization in patients with radiation cystitis. Results from a large retrospective study. J Urol 2016; 195 (Suppl. 4): e956–e957.
11. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007; 23: 303–12.
12. Islam R, Issacson BJ, Zickerman PM et al. Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: Case report. Am J Clin Oncol 2002; 25: 513–4.
13. Marx CM, Alpert SE. Ticarcillin-induced cystitis. Cross reactivity with related pencillin. Am J Dis Child 1984; 138: 670–2.
14. Andriole GL, Brickman C, Lack EE et al. Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. J Urol 1986; 135 (1): 44–6.
15. Naber KG et al. Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur Urol 2008; 54 (5): 1164–75.
16. Naber K, Scaeffer A, Heyns C et al. Urogenital Infections. 2010.
17. Erard V, Storer B, Corey L et al. BK virus infection in haematopoietic stem cell transplant receipents: Frequency, risk factors and association with post engraftment haemorrhagic cystitis. Clin Infect Dis 2004; 39: 1861–5.
18. Azzi A, Ciappi S, De Santis R et al. Hemorrhagic cystitis associated with BKV in patients with refractory acute lymphoblastic leukemia. Am J Hematol 1996; 52 (2): 121–2.
19. Azzi A, Fanci R, Bosi A et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorrhagic cystitis. Bone Marrow Transplant 1994; 14 (2): 235–40.
20. Bedi A, Miller CB, Hanson JL et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995; 13 (5): 1103–9.
21. Erard V, Kim HW, Corey L et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 2005; 106 (3): 1130–2.
22. Giraud G, Bogdanovic G, Priftakis P et al. The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen. Haematologica 2006; 91 (3): 401–4.
23. Mylonakis E, Goes N, Rubin RH et al. BK virus in solid organ transplant recipients: an emerging syndrome. Transplantation 2001; 72 (10): 1587–92.
24. Mori Y, Miyamoto T, Kato K et al. Different risk factors related to adenovirus or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2011; 31.
25. Haines HL, Laskin BL, Goebel J et al. Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17 (10): 1512–9.
26. Hoffman JA, Shah AJ, Ross LA, Kapoor N. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7 (7): 388–94.
27. Hofland CA, Eron LJ, Washecka RM. Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc 2004; 36 (10): 3025–7.
28. Ison MG. Adenovirus infections in transplant recipients. Clin Infect Dis 2006; 43 (3): 331–9.
29. Spach DH, Bauwens JE, Myerson D et al. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993; 16 (1): 142–4.
30. Tutuncuoglu SO, Yanovich S, Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant 2005; 36 (3): 265–6.
31. Focosi D, Kast RE. Hyaluronate and risperidone for hemorrhagic cystitis. Bone Marrow Transplant 2007; 39 (1): 57.
32. McClanahan C, Grimes MM, Callaghan E, Stewart J. Hemorrhagic cystitis associated with herpes simplex virus. J Urol 1994; 151 (1): 152–3.
33. Nguyen ML, Borochovitz D, Thomas G et al. Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa. Clin Infect Dis 1992; 14 (3): 767–8.
34. Uhm J, Hamad N, Michelis FV et al. The risk of polyomavirus BK-associated hemorrhagic cystitis after allogeneic hematopoietic SCT is associated with myeloablative conditioning, CMV viremia and severe acute GVHD. Bone Marrow Transplant 2014; 49 (12).
35. Lunde LE, Dasaraju S, Cao Q et al. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant 2015; 13.
36. Gorczynska E, Turkiewicz D, Rybka K et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2005; 11 (10): 797–804.
37. Smit SG, Heyns CF. Management of radiation cystitis. Nat Rev Urol 2010; 7: 206–14.
38. Payne H, Adamson A, Bahl A et al. Chemical and radiation induced haemorrhagic cystitis: current treatments and challenges. BJU Int 2013; 112: 885–97.
39. Corman JM, McClure D, Pritchett R et al. Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen. J Urol 2003; 169 (6): 2200–2.
40. Zwaans BM, Chancellor MB, Lamb LE. Modeling and treatment of radiation cystitis. Urology 2015; DOI: 10.1016/j.urology.2015.11.001
41. Schoenike SE, Dana WJ. Ifosfamide and mesna. Clin Pharm 1990; 9: 179–91.
42. Ribeiro RA, Freitas HC, Campos MC et al. Tumor necrosis factor-alpha and interleukin-1 beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol 2002; 167: 2229–34.
43. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007; 23: 303–12.
44. Gomes TN, Santos CC, Souza-Filho MV et al. Participation of TNF-alpha and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Braz J Med Biol Res 1995; 28: 1103–8.
45. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996; 271: 1424–37.
46. Kimura M, Tomita Y, Morishita H, Takahashi K. Presence of mucosal change in the urinary bladder in non hematuria patients with long-term exposure and/or accumulating high-dose cyclophosohamide. Possible significance of follow-up cystoscopy on preventing development of cyclophosphamide-induced hemorrhagic cystitis. Urol Int 1998; 61: 8–11.
47. Krane DM, Levine LA. Hemorrhagic cystitis. AUA Update Series 1992; XI: Lesson 31.
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51. Talar-Williams C, Hijazi YM, Walther MM et al. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener′s granulomatosis. Ann Intern Med 1996; 124: 477–84.
52. Droller MJ, Saral R, Santos G. Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 1982; 20: 256–8.
53. Radcliffe K, European STD Guidelines, 2004.
54. Paduch DA. Viral lower urinary tract infections. Curr Urol Rep 2007; 8: 324–35.
55. Zaleska-Dorobisz U, Biel A, Sokołowska-Dąbek D et al. Ultrasonography in the diagnosis of hemorrhagic cystitis – a complication of bone marrow transplantation in pediatric oncology patients. J Ultrason 2014; 14 (58): 258–72.
56. Epstein J, Reuter V, Amin M. Biopsy Interpretation of the Bladder. 2nd edition, 2011.
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25. Haines HL, Laskin BL, Goebel J et al. Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17 (10): 1512–9.
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27. Hofland CA, Eron LJ, Washecka RM. Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc 2004; 36 (10): 3025–7.
28. Ison MG. Adenovirus infections in transplant recipients. Clin Infect Dis 2006; 43 (3): 331–9.
29. Spach DH, Bauwens JE, Myerson D et al. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993; 16 (1): 142–4.
30. Tutuncuoglu SO, Yanovich S, Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant 2005; 36 (3): 265–6.
31. Focosi D, Kast RE. Hyaluronate and risperidone for hemorrhagic cystitis. Bone Marrow Transplant 2007; 39 (1): 57.
32. McClanahan C, Grimes MM, Callaghan E, Stewart J. Hemorrhagic cystitis associated with herpes simplex virus. J Urol 1994; 151 (1): 152–3.
33. Nguyen ML, Borochovitz D, Thomas G et al. Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa. Clin Infect Dis 1992; 14 (3): 767–8.
34. Uhm J, Hamad N, Michelis FV et al. The risk of polyomavirus BK-associated hemorrhagic cystitis after allogeneic hematopoietic SCT is associated with myeloablative conditioning, CMV viremia and severe acute GVHD. Bone Marrow Transplant 2014; 49 (12).
35. Lunde LE, Dasaraju S, Cao Q et al. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant 2015; 13.
36. Gorczynska E, Turkiewicz D, Rybka K et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2005; 11 (10): 797–804.
37. Smit SG, Heyns CF. Management of radiation cystitis. Nat Rev Urol 2010; 7: 206–14.
38. Payne H, Adamson A, Bahl A et al. Chemical and radiation induced haemorrhagic cystitis: current treatments and challenges. BJU Int 2013; 112: 885–97.
39. Corman JM, McClure D, Pritchett R et al. Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen. J Urol 2003; 169 (6): 2200–2.
40. Zwaans BM, Chancellor MB, Lamb LE. Modeling and treatment of radiation cystitis. Urology 2015; DOI: 10.1016/j.urology.2015.11.001
41. Schoenike SE, Dana WJ. Ifosfamide and mesna. Clin Pharm 1990; 9: 179–91.
42. Ribeiro RA, Freitas HC, Campos MC et al. Tumor necrosis factor-alpha and interleukin-1 beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol 2002; 167: 2229–34.
43. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007; 23: 303–12.
44. Gomes TN, Santos CC, Souza-Filho MV et al. Participation of TNF-alpha and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Braz J Med Biol Res 1995; 28: 1103–8.
45. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996; 271: 1424–37.
46. Kimura M, Tomita Y, Morishita H, Takahashi K. Presence of mucosal change in the urinary bladder in non hematuria patients with long-term exposure and/or accumulating high-dose cyclophosohamide. Possible significance of follow-up cystoscopy on preventing development of cyclophosphamide-induced hemorrhagic cystitis. Urol Int 1998; 61: 8–11.
47. Krane DM, Levine LA. Hemorrhagic cystitis. AUA Update Series 1992; XI: Lesson 31.
48. Amvros'eva T.V., Dediulia K.L., Poklonskaia N.V., Bogush Z.F. Poliomavirusnaia infektsiia cheloveka: znachenie v patologii i genodiagnostika. Zdravookhranenie. 2014; 10. [in Russian]
49. Skriabin G.N., Aleksandrov V.P., Koren'kov D.G., Nazarov T.N. Tsistity. Uchebn. posobie. SPb., 2006. [in Russian]
50. Isakov V.A., Arkhipova E.I., Isakov D.V. Gerpesvirusnye infektsii cheloveka. 2011. [in Russian]
51. Talar-Williams C, Hijazi YM, Walther MM et al. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener′s granulomatosis. Ann Intern Med 1996; 124: 477–84.
52. Droller MJ, Saral R, Santos G. Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 1982; 20: 256–8.
53. Radcliffe K, European STD Guidelines, 2004.
54. Paduch DA. Viral lower urinary tract infections. Curr Urol Rep 2007; 8: 324–35.
55. Zaleska-Dorobisz U, Biel A, Sokołowska-Dąbek D et al. Ultrasonography in the diagnosis of hemorrhagic cystitis – a complication of bone marrow transplantation in pediatric oncology patients. J Ultrason 2014; 14 (58): 258–72.
56. Epstein J, Reuter V, Amin M. Biopsy Interpretation of the Bladder. 2nd edition, 2011.
Авторы
О.Б.Лоран*, Л.А.Синякова, Я.И.Незовибатько
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1
*olegloran@gmail.com
Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1
*olegloran@gmail.com
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1
*olegloran@gmail.com
________________________________________________
Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1
*olegloran@gmail.com
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.