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Гангренозная пиодермия: современное состояние проблемы
Гангренозная пиодермия: современное состояние проблемы
Жучков М.В., Копейкин А.А., Ловков И.М. и др. Гангренозная пиодермия: современное состояние проблемы. Consilium Medicum. 2017; 19 (7.2. Хирургия): 23–27. DOI: 10.26442/2075-1753_19.7.2.23-27
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Аннотация
В статье приводятся данные литературы, посвященные современному состоянию проблемы этиологии патогенеза, диагностики и лечения гангренозной пиодермии. Авторы также приводят собственные наблюдения и опыт использования микофенолата мофетила при гангренозной пиодермии.
Ключевые слова: гангренозная пиодермия, нейтрофильный дерматоз.
Key words: gangrenous pyoderma, neutrophilic dermatosis.
Ключевые слова: гангренозная пиодермия, нейтрофильный дерматоз.
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Key words: gangrenous pyoderma, neutrophilic dermatosis.
Полный текст
Список литературы
1. Powell FC, Su WP, Perry HO. Pyoderma gangrenosum: classification and management. J Am Acad Dermatology 1996; 34: 395.
2. Bennett ML et al. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore) 2000; 79 (1): 37–46.
3. Powell FC et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med 1985; 55 (217): 173–86.
4. Jain A et al. Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. Indian J Hematol Blood Transfus 2017; 33 (2): 273–5.
5. Vandemergel X et al. Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report. Rev Med Brux 2017; 38 (2): 95–8.
6. Okamura K et al. A case of primarily facial pyoderma gangrenosum associated with Takayasu arteritis. JAAD Case Rep 2017; 3 (2): 124–6.
7. Gobert J, Mercuzot A, Sergent F. A new pyoderma gangrenosum case revealing breast cancer. Gynecol Obstet Fertil Senol 2017; 45 (1): 54–5.
8. Maranda EL et al. A case of eosinophilic fasciitis associated with pyoderma gangrenosum. J Eur Acad Dermatol Venereol 2017; 31 (2): e101–e102.
9. Lane CG. Pyoderma gangrenosum. Arch Derm Syphilol 1947; 55 (5): 714.
10. T helper 1-related molecules as well as IL-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum. Clin Exp Immunol 2017; 189 (3): 383–91.
11. Antiga E, Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (PG): an updated review. J Am Acad Dermatol 2015; 73 (4): 691–8.
12. Karimi K et al. Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment. J Cutan Med Surg 2017; 21 (5): 425.
13. Gameiro A et al. Pyoderma gangrenosum: challenges and solutions. Clin Cosmet Investig Dermatol 2015; 8: 285–93.
14. Marzano AV et al. Pyoderma gangrenosum with severe cutaneous and oral involvement. Eur J Dermatol 2013; 23 (2): 257–8.
15. Chaby G et al. Topical silver sulfadiazine-induced acute renal failure. Ann Dermatol Venereol 2005; 132 (11 Pt. 1): 891–3.
16. Rodenbeck DL, Kennon AW, Davis LS. Peristomal pyoderma gangrenosum (PG): A simple hydrocolloid dressing technique to promote wound healing. J Am Acad Dermatol 2015; 73 (3): 107–8.
17. Smith KC, Su WP, Leiferman KM. Cromolyn sodium in 2% aqueous solution under an occlusive hydrocolloid dressing may be effective adjunctive treatment in management of pyoderma gangrenosum. J Am Acad Dermatol 1987; 17 (3): 509–11.
18. Винник Ю.С., Маркелова Н.М., Тюрюмин В.С. Современные методы лечения гнойных ран. Сиб. мед. образование. 2013; 1: 18–24. / Vinnik Yu.S., Markelova N.M., Tyuryumin V.S. Sovremennye metody lecheniia gnoinykh ran. Sib. med. obrazovanie. 2013; 1: 18–24. [in Russian]
19. Wirtzfeld N et al. Pathergic postsurgical-induced Pyoderma gangrenosum. Rev Med Liege 2017; 72 (5): 227–32.
20. Barańska-Rybak W et al. A retrospective study of 12 cases of pyoderma gangrenosum: why we should avoid surgical intervention and what therapy to apply. Am Surg 2011; 77 (12): 1644–9.
21. Goshtasby PH, Chami RG, Johnson RM. A novel approach to the management of pyoderma gangrenosum complicating reduction mammoplasty. Aesthet Surg J 2010; 30 (2): 186–93.
22. Patel DK, Locke M, Jarrett P. Pyoderma gangrenosum with pathergy: A potentially significant complication following breast reconstruction. J Plast Reconstr Aesthet Surg 2017; 70 (7): 884–92.
23. Ruebhausen MR et al. Postsurgical Pyoderma Gangrenosum Following Carpal Tunnel Release: A Rare Disease Following a Common Surgery. Eplasty 2017; 17: 10.
24. Kechichian E et al. Pediatric pyoderma gangrenosum: a systematic review and update. Int J Dermatol 2017; 56 (5): 486–95. DOI: 10.1111/ijd.13584
25. Larsen CG, Thyssen JP. Pustular penile pyoderma gangrenosum successfully treated with topical tacrolimus ointment. Acta Derm Venereol 2012; 92 (1): 104–5.
26. Thomas KS et al. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol 2016; 75 (5): 940–9.
27. Van Der Hoeden R et al. Pyoderma gangrenosum complicating ulcerative colitis; cure during cortisone therapy. Acta Gastroenterol Belg 1955; 18 (3): 246–57.
28. Pompeo MQ. Pyoderma Gangrenosum: Recognition and Management. Wounds 2016; 28 (1): 7–13.
29. Brown RE, Lay L, Graham D. Bilateral pyoderma gangrenosum of the hand: treatment with dapsone. J Hand Surg Br 1993; 18 (1): 119–21.
30. Kaplan B et al. Treatment of pyoderma gangrenosum with clofazimine. Int J Dermatol 1992; 31 (8): 591–3.
31. Matis WL et al. Treatment of pyoderma gangrenosum with cyclosporine. Arch Dermatol 1992; 128 (8): 1060–4.
32. Teitel AD. Treatment of pyoderma gangrenosum with methotrexate. Cutis 1996; 57 (5): 326–8.
33. Hohenleutner U et al. Mycophenolate mofetil and cyclosporin treatment for recalcitrant pyoderma gangrenosum. Lancet 1997; 350 (9093): 1748.
34. Nousari HC et al. The effectiveness of mycophenolate mofetil in refractory pyoderma gangrenosum. Arch Dermatol 1998; 134 (12): 1509–11.
35. Al Ghazal P, Dissemond J. Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts. J Dtsch Dermatol Ges 2015; 13 (4): 317–24.
36. Bobbitt SA et al. Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. Dermatol Online J 2016; 22 (4).
37. Lankarani KB. Infliximab for treatment of pyoderma gangrenosum. Neth J Med 2015; 73 (7): 357.
2. Bennett ML et al. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore) 2000; 79 (1): 37–46.
3. Powell FC et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med 1985; 55 (217): 173–86.
4. Jain A et al. Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. Indian J Hematol Blood Transfus 2017; 33 (2): 273–5.
5. Vandemergel X et al. Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report. Rev Med Brux 2017; 38 (2): 95–8.
6. Okamura K et al. A case of primarily facial pyoderma gangrenosum associated with Takayasu arteritis. JAAD Case Rep 2017; 3 (2): 124–6.
7. Gobert J, Mercuzot A, Sergent F. A new pyoderma gangrenosum case revealing breast cancer. Gynecol Obstet Fertil Senol 2017; 45 (1): 54–5.
8. Maranda EL et al. A case of eosinophilic fasciitis associated with pyoderma gangrenosum. J Eur Acad Dermatol Venereol 2017; 31 (2): e101–e102.
9. Lane CG. Pyoderma gangrenosum. Arch Derm Syphilol 1947; 55 (5): 714.
10. T helper 1-related molecules as well as IL-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum. Clin Exp Immunol 2017; 189 (3): 383–91.
11. Antiga E, Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (PG): an updated review. J Am Acad Dermatol 2015; 73 (4): 691–8.
12. Karimi K et al. Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment. J Cutan Med Surg 2017; 21 (5): 425.
13. Gameiro A et al. Pyoderma gangrenosum: challenges and solutions. Clin Cosmet Investig Dermatol 2015; 8: 285–93.
14. Marzano AV et al. Pyoderma gangrenosum with severe cutaneous and oral involvement. Eur J Dermatol 2013; 23 (2): 257–8.
15. Chaby G et al. Topical silver sulfadiazine-induced acute renal failure. Ann Dermatol Venereol 2005; 132 (11 Pt. 1): 891–3.
16. Rodenbeck DL, Kennon AW, Davis LS. Peristomal pyoderma gangrenosum (PG): A simple hydrocolloid dressing technique to promote wound healing. J Am Acad Dermatol 2015; 73 (3): 107–8.
17. Smith KC, Su WP, Leiferman KM. Cromolyn sodium in 2% aqueous solution under an occlusive hydrocolloid dressing may be effective adjunctive treatment in management of pyoderma gangrenosum. J Am Acad Dermatol 1987; 17 (3): 509–11.
18. Vinnik Yu.S., Markelova N.M., Tyuryumin V.S. Sovremennye metody lecheniia gnoinykh ran. Sib. med. obrazovanie. 2013; 1: 18–24. [in Russian]
19. Wirtzfeld N et al. Pathergic postsurgical-induced Pyoderma gangrenosum. Rev Med Liege 2017; 72 (5): 227–32.
20. Barańska-Rybak W et al. A retrospective study of 12 cases of pyoderma gangrenosum: why we should avoid surgical intervention and what therapy to apply. Am Surg 2011; 77 (12): 1644–9.
21. Goshtasby PH, Chami RG, Johnson RM. A novel approach to the management of pyoderma gangrenosum complicating reduction mammoplasty. Aesthet Surg J 2010; 30 (2): 186–93.
22. Patel DK, Locke M, Jarrett P. Pyoderma gangrenosum with pathergy: A potentially significant complication following breast reconstruction. J Plast Reconstr Aesthet Surg 2017; 70 (7): 884–92.
23. Ruebhausen MR et al. Postsurgical Pyoderma Gangrenosum Following Carpal Tunnel Release: A Rare Disease Following a Common Surgery. Eplasty 2017; 17: 10.
24. Kechichian E et al. Pediatric pyoderma gangrenosum: a systematic review and update. Int J Dermatol 2017; 56 (5): 486–95. DOI: 10.1111/ijd.13584
25. Larsen CG, Thyssen JP. Pustular penile pyoderma gangrenosum successfully treated with topical tacrolimus ointment. Acta Derm Venereol 2012; 92 (1): 104–5.
26. Thomas KS et al. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol 2016; 75 (5): 940–9.
27. Van Der Hoeden R et al. Pyoderma gangrenosum complicating ulcerative colitis; cure during cortisone therapy. Acta Gastroenterol Belg 1955; 18 (3): 246–57.
28. Pompeo MQ. Pyoderma Gangrenosum: Recognition and Management. Wounds 2016; 28 (1): 7–13.
29. Brown RE, Lay L, Graham D. Bilateral pyoderma gangrenosum of the hand: treatment with dapsone. J Hand Surg Br 1993; 18 (1): 119–21.
30. Kaplan B et al. Treatment of pyoderma gangrenosum with clofazimine. Int J Dermatol 1992; 31 (8): 591–3.
31. Matis WL et al. Treatment of pyoderma gangrenosum with cyclosporine. Arch Dermatol 1992; 128 (8): 1060–4.
32. Teitel AD. Treatment of pyoderma gangrenosum with methotrexate. Cutis 1996; 57 (5): 326–8.
33. Hohenleutner U et al. Mycophenolate mofetil and cyclosporin treatment for recalcitrant pyoderma gangrenosum. Lancet 1997; 350 (9093): 1748.
34. Nousari HC et al. The effectiveness of mycophenolate mofetil in refractory pyoderma gangrenosum. Arch Dermatol 1998; 134 (12): 1509–11.
35. Al Ghazal P, Dissemond J. Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts. J Dtsch Dermatol Ges 2015; 13 (4): 317–24.
36. Bobbitt SA et al. Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. Dermatol Online J 2016; 22 (4).
37. Lankarani KB. Infliximab for treatment of pyoderma gangrenosum. Neth J Med 2015; 73 (7): 357.
2. Bennett ML et al. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore) 2000; 79 (1): 37–46.
3. Powell FC et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med 1985; 55 (217): 173–86.
4. Jain A et al. Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. Indian J Hematol Blood Transfus 2017; 33 (2): 273–5.
5. Vandemergel X et al. Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report. Rev Med Brux 2017; 38 (2): 95–8.
6. Okamura K et al. A case of primarily facial pyoderma gangrenosum associated with Takayasu arteritis. JAAD Case Rep 2017; 3 (2): 124–6.
7. Gobert J, Mercuzot A, Sergent F. A new pyoderma gangrenosum case revealing breast cancer. Gynecol Obstet Fertil Senol 2017; 45 (1): 54–5.
8. Maranda EL et al. A case of eosinophilic fasciitis associated with pyoderma gangrenosum. J Eur Acad Dermatol Venereol 2017; 31 (2): e101–e102.
9. Lane CG. Pyoderma gangrenosum. Arch Derm Syphilol 1947; 55 (5): 714.
10. T helper 1-related molecules as well as IL-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum. Clin Exp Immunol 2017; 189 (3): 383–91.
11. Antiga E, Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (PG): an updated review. J Am Acad Dermatol 2015; 73 (4): 691–8.
12. Karimi K et al. Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment. J Cutan Med Surg 2017; 21 (5): 425.
13. Gameiro A et al. Pyoderma gangrenosum: challenges and solutions. Clin Cosmet Investig Dermatol 2015; 8: 285–93.
14. Marzano AV et al. Pyoderma gangrenosum with severe cutaneous and oral involvement. Eur J Dermatol 2013; 23 (2): 257–8.
15. Chaby G et al. Topical silver sulfadiazine-induced acute renal failure. Ann Dermatol Venereol 2005; 132 (11 Pt. 1): 891–3.
16. Rodenbeck DL, Kennon AW, Davis LS. Peristomal pyoderma gangrenosum (PG): A simple hydrocolloid dressing technique to promote wound healing. J Am Acad Dermatol 2015; 73 (3): 107–8.
17. Smith KC, Su WP, Leiferman KM. Cromolyn sodium in 2% aqueous solution under an occlusive hydrocolloid dressing may be effective adjunctive treatment in management of pyoderma gangrenosum. J Am Acad Dermatol 1987; 17 (3): 509–11.
18. Винник Ю.С., Маркелова Н.М., Тюрюмин В.С. Современные методы лечения гнойных ран. Сиб. мед. образование. 2013; 1: 18–24. / Vinnik Yu.S., Markelova N.M., Tyuryumin V.S. Sovremennye metody lecheniia gnoinykh ran. Sib. med. obrazovanie. 2013; 1: 18–24. [in Russian]
19. Wirtzfeld N et al. Pathergic postsurgical-induced Pyoderma gangrenosum. Rev Med Liege 2017; 72 (5): 227–32.
20. Barańska-Rybak W et al. A retrospective study of 12 cases of pyoderma gangrenosum: why we should avoid surgical intervention and what therapy to apply. Am Surg 2011; 77 (12): 1644–9.
21. Goshtasby PH, Chami RG, Johnson RM. A novel approach to the management of pyoderma gangrenosum complicating reduction mammoplasty. Aesthet Surg J 2010; 30 (2): 186–93.
22. Patel DK, Locke M, Jarrett P. Pyoderma gangrenosum with pathergy: A potentially significant complication following breast reconstruction. J Plast Reconstr Aesthet Surg 2017; 70 (7): 884–92.
23. Ruebhausen MR et al. Postsurgical Pyoderma Gangrenosum Following Carpal Tunnel Release: A Rare Disease Following a Common Surgery. Eplasty 2017; 17: 10.
24. Kechichian E et al. Pediatric pyoderma gangrenosum: a systematic review and update. Int J Dermatol 2017; 56 (5): 486–95. DOI: 10.1111/ijd.13584
25. Larsen CG, Thyssen JP. Pustular penile pyoderma gangrenosum successfully treated with topical tacrolimus ointment. Acta Derm Venereol 2012; 92 (1): 104–5.
26. Thomas KS et al. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol 2016; 75 (5): 940–9.
27. Van Der Hoeden R et al. Pyoderma gangrenosum complicating ulcerative colitis; cure during cortisone therapy. Acta Gastroenterol Belg 1955; 18 (3): 246–57.
28. Pompeo MQ. Pyoderma Gangrenosum: Recognition and Management. Wounds 2016; 28 (1): 7–13.
29. Brown RE, Lay L, Graham D. Bilateral pyoderma gangrenosum of the hand: treatment with dapsone. J Hand Surg Br 1993; 18 (1): 119–21.
30. Kaplan B et al. Treatment of pyoderma gangrenosum with clofazimine. Int J Dermatol 1992; 31 (8): 591–3.
31. Matis WL et al. Treatment of pyoderma gangrenosum with cyclosporine. Arch Dermatol 1992; 128 (8): 1060–4.
32. Teitel AD. Treatment of pyoderma gangrenosum with methotrexate. Cutis 1996; 57 (5): 326–8.
33. Hohenleutner U et al. Mycophenolate mofetil and cyclosporin treatment for recalcitrant pyoderma gangrenosum. Lancet 1997; 350 (9093): 1748.
34. Nousari HC et al. The effectiveness of mycophenolate mofetil in refractory pyoderma gangrenosum. Arch Dermatol 1998; 134 (12): 1509–11.
35. Al Ghazal P, Dissemond J. Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts. J Dtsch Dermatol Ges 2015; 13 (4): 317–24.
36. Bobbitt SA et al. Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. Dermatol Online J 2016; 22 (4).
37. Lankarani KB. Infliximab for treatment of pyoderma gangrenosum. Neth J Med 2015; 73 (7): 357.
________________________________________________
2. Bennett ML et al. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore) 2000; 79 (1): 37–46.
3. Powell FC et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med 1985; 55 (217): 173–86.
4. Jain A et al. Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. Indian J Hematol Blood Transfus 2017; 33 (2): 273–5.
5. Vandemergel X et al. Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report. Rev Med Brux 2017; 38 (2): 95–8.
6. Okamura K et al. A case of primarily facial pyoderma gangrenosum associated with Takayasu arteritis. JAAD Case Rep 2017; 3 (2): 124–6.
7. Gobert J, Mercuzot A, Sergent F. A new pyoderma gangrenosum case revealing breast cancer. Gynecol Obstet Fertil Senol 2017; 45 (1): 54–5.
8. Maranda EL et al. A case of eosinophilic fasciitis associated with pyoderma gangrenosum. J Eur Acad Dermatol Venereol 2017; 31 (2): e101–e102.
9. Lane CG. Pyoderma gangrenosum. Arch Derm Syphilol 1947; 55 (5): 714.
10. T helper 1-related molecules as well as IL-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum. Clin Exp Immunol 2017; 189 (3): 383–91.
11. Antiga E, Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (PG): an updated review. J Am Acad Dermatol 2015; 73 (4): 691–8.
12. Karimi K et al. Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment. J Cutan Med Surg 2017; 21 (5): 425.
13. Gameiro A et al. Pyoderma gangrenosum: challenges and solutions. Clin Cosmet Investig Dermatol 2015; 8: 285–93.
14. Marzano AV et al. Pyoderma gangrenosum with severe cutaneous and oral involvement. Eur J Dermatol 2013; 23 (2): 257–8.
15. Chaby G et al. Topical silver sulfadiazine-induced acute renal failure. Ann Dermatol Venereol 2005; 132 (11 Pt. 1): 891–3.
16. Rodenbeck DL, Kennon AW, Davis LS. Peristomal pyoderma gangrenosum (PG): A simple hydrocolloid dressing technique to promote wound healing. J Am Acad Dermatol 2015; 73 (3): 107–8.
17. Smith KC, Su WP, Leiferman KM. Cromolyn sodium in 2% aqueous solution under an occlusive hydrocolloid dressing may be effective adjunctive treatment in management of pyoderma gangrenosum. J Am Acad Dermatol 1987; 17 (3): 509–11.
18. Vinnik Yu.S., Markelova N.M., Tyuryumin V.S. Sovremennye metody lecheniia gnoinykh ran. Sib. med. obrazovanie. 2013; 1: 18–24. [in Russian]
19. Wirtzfeld N et al. Pathergic postsurgical-induced Pyoderma gangrenosum. Rev Med Liege 2017; 72 (5): 227–32.
20. Barańska-Rybak W et al. A retrospective study of 12 cases of pyoderma gangrenosum: why we should avoid surgical intervention and what therapy to apply. Am Surg 2011; 77 (12): 1644–9.
21. Goshtasby PH, Chami RG, Johnson RM. A novel approach to the management of pyoderma gangrenosum complicating reduction mammoplasty. Aesthet Surg J 2010; 30 (2): 186–93.
22. Patel DK, Locke M, Jarrett P. Pyoderma gangrenosum with pathergy: A potentially significant complication following breast reconstruction. J Plast Reconstr Aesthet Surg 2017; 70 (7): 884–92.
23. Ruebhausen MR et al. Postsurgical Pyoderma Gangrenosum Following Carpal Tunnel Release: A Rare Disease Following a Common Surgery. Eplasty 2017; 17: 10.
24. Kechichian E et al. Pediatric pyoderma gangrenosum: a systematic review and update. Int J Dermatol 2017; 56 (5): 486–95. DOI: 10.1111/ijd.13584
25. Larsen CG, Thyssen JP. Pustular penile pyoderma gangrenosum successfully treated with topical tacrolimus ointment. Acta Derm Venereol 2012; 92 (1): 104–5.
26. Thomas KS et al. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol 2016; 75 (5): 940–9.
27. Van Der Hoeden R et al. Pyoderma gangrenosum complicating ulcerative colitis; cure during cortisone therapy. Acta Gastroenterol Belg 1955; 18 (3): 246–57.
28. Pompeo MQ. Pyoderma Gangrenosum: Recognition and Management. Wounds 2016; 28 (1): 7–13.
29. Brown RE, Lay L, Graham D. Bilateral pyoderma gangrenosum of the hand: treatment with dapsone. J Hand Surg Br 1993; 18 (1): 119–21.
30. Kaplan B et al. Treatment of pyoderma gangrenosum with clofazimine. Int J Dermatol 1992; 31 (8): 591–3.
31. Matis WL et al. Treatment of pyoderma gangrenosum with cyclosporine. Arch Dermatol 1992; 128 (8): 1060–4.
32. Teitel AD. Treatment of pyoderma gangrenosum with methotrexate. Cutis 1996; 57 (5): 326–8.
33. Hohenleutner U et al. Mycophenolate mofetil and cyclosporin treatment for recalcitrant pyoderma gangrenosum. Lancet 1997; 350 (9093): 1748.
34. Nousari HC et al. The effectiveness of mycophenolate mofetil in refractory pyoderma gangrenosum. Arch Dermatol 1998; 134 (12): 1509–11.
35. Al Ghazal P, Dissemond J. Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts. J Dtsch Dermatol Ges 2015; 13 (4): 317–24.
36. Bobbitt SA et al. Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. Dermatol Online J 2016; 22 (4).
37. Lankarani KB. Infliximab for treatment of pyoderma gangrenosum. Neth J Med 2015; 73 (7): 357.
Авторы
М.В.Жучков1,2*, А.А.Копейкин1,3, И.М.Ловков3, А.В.Синяков3, В.И.Рогачев3, У.В.Жучкова3
1. ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П.Павлова» Минздрава России». 390013, Россия, Рязань, ул. Высоковольтная, д. 9;
2. ГБУ РО «Областной клинический кожно-венерологический диспансер». 390046, Россия, Рязань, ул. Спортивная, д. 9;
3. ГБУ РО «Городская клиническая больница скорой медицинской помощи». 390013, Россия, Рязань, ул. Дзержинского, д. 11
*misha.juchkov@gmail.com
1. I.P.Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation. 390026, Russian Federation, Ryazan, ul. Vysokovol'tnaia, d. 9;
2. Ryazan State Regional Dermato-Venerological Clinic. 390046, Russian Federation, Ryazan, ul. Sportivnaia, d. 9;
3. City Clinical Emergency Hospital. 390013, Russian Federation, Ryazan, ul. Dzerzhinskogo, d. 11
*misha.juchkov@gmail.com
1. ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П.Павлова» Минздрава России». 390013, Россия, Рязань, ул. Высоковольтная, д. 9;
2. ГБУ РО «Областной клинический кожно-венерологический диспансер». 390046, Россия, Рязань, ул. Спортивная, д. 9;
3. ГБУ РО «Городская клиническая больница скорой медицинской помощи». 390013, Россия, Рязань, ул. Дзержинского, д. 11
*misha.juchkov@gmail.com
________________________________________________
1. I.P.Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation. 390026, Russian Federation, Ryazan, ul. Vysokovol'tnaia, d. 9;
2. Ryazan State Regional Dermato-Venerological Clinic. 390046, Russian Federation, Ryazan, ul. Sportivnaia, d. 9;
3. City Clinical Emergency Hospital. 390013, Russian Federation, Ryazan, ul. Dzerzhinskogo, d. 11
*misha.juchkov@gmail.com
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