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Хронический запор: актуальность, проблемы и современные возможности лечения
Хронический запор: актуальность, проблемы и современные возможности лечения
Кучерявый Ю.А., Андреев Д.Н., Черемушкин С.В. Хронический запор: актуальность проблемы и современные возможности лечения. Consilium Medicum. 2017; 19 (8): 116–120. DOI: 10.26442/2075-1753_19.8.116-120
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Аннотация
Хронический запор является важнейшей глобальной медико-социальной проблемой, а вопросы рациональной терапии данного состояния – одной из самых актуальных тем в современной гастроэнтерологии. Терапевтические подходы в лечении хронического запора должны характеризоваться стадийной последовательностью. Лечение должно начинаться с модификации образа жизни пациента, увеличения потребления жидкости до 1,5–2 л в сутки, включения в рацион питания пищевых продуктов, содержащих большое количество пищевых волокон, в частности пшеничных отрубей, или использования псиллиума. При неэффективности данных мероприятий целесообразно применение фармакотерапии, в рамках которой приоритет следует отдавать невсасывающимся дисахаридам, в частности представителю последнего поколения – лактитолу (Экспортал®). Данный препарат в рамках лечения хронического запора характеризуется эквивалентной и в ряде случаев большей эффективностью по сравнению с невсасывающимся дисахаридом раннего поколения (лактулоза) и обладает лучшим профилем безопасности (частота побочных явлений в 1,5–2 раза ниже), а также лучшими вкусовыми качествами, что позволяет его рассматривать как терапию 1-й линии при лечении хронического запора.
Ключевые слова: хронический запор, функциональный запор, Римские критерии IV пересмотра, слабительные, невсасывающиеся дисахариды, лактулоза, лактитол.
Key words: chronic constipation, functional constipation, the Rome IV criteria, laxatives, non-absorbable disaccharides, lactulose, lactitol.
Ключевые слова: хронический запор, функциональный запор, Римские критерии IV пересмотра, слабительные, невсасывающиеся дисахариды, лактулоза, лактитол.
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Key words: chronic constipation, functional constipation, the Rome IV criteria, laxatives, non-absorbable disaccharides, lactulose, lactitol.
Полный текст
Список литературы
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34. Greer JB, O'Keefe SJ. Microbial induction of immunity, inflammation, and cancer. Front Physiol 2011; 1: 168.
35. Illanes A, Guerrero C, Vera C et al. Lactose-Derived Prebiotics: A Process Perspective. UK, 2016.
36. Wright RA. Lactulose-induced megacolon. Gastrointest Endosc 1988; 34: 489–90.
37. Faruqui AA, Joshi C. Lactitol: a review of its use in the treatment of constipation. Int J Recent Adv Pharm Res 2012; 2 (1): 1–5.
38. Maydeo A. Lactitol or lactulose in the treatment of chronic constipation: result of a systematic. J Indian Med Assoc 2010; 108 (11): 789–92.
39. Chen C, Li L, Wu Z et al. Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. J Infect 2007; 54 (1): 98–102.
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41. Miller LE, Tennilä J, Ouwehand AC. Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis. Clin Exp Gastroenterol 2014; 7: 241–8.
42. Xu Z, Dai J, Shi R et al. A multicenter, randomized, single-blinded, parallel-controlled trial on lactitol in treatment of constipation. Chin J Gastroenterology 2012; 17 (3): 168–72.
43. Doffoel M, Berthel M, Bockel R et al. Comparative study of lactitol and lactulose in the treatment of functional constipation in elderly subjects. Medecine Chirurgie Digestives (Paris) 1990; 19 (4): 257–9.
44. Hammer B, Ravelli GP. Chronic functional constipation: lactitol maintenance dose, a multicentre comparative study with lactulose. Ther Schweiz 1992; 8: 328–35.
45. Heitland W, Mauersberger H. A clinical investigation comparing the laxative effect of lactitol to that of lactulose in a randomised, open, parallel study. Schweiz Rundsch Med Prax 1988; 77 (18): 493–5.
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47. Pitzalis G, Deganello F, Mariani P et al. Lactitol in chronic idiopathic constipation in children. Pediatr Med Chir 1995; 17 (3): 223–6.
48. Santhosh KM, Jagadeesh K, Shreenivas PR. Clinical efficacy and safety of lactitol versus lactulose in the treatment of constipation. Int J Institut Pharm Life Sci 2015; 5 (2): 265–71.
49. Cammà C, Fiorello F, Tinè F et al. Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis. Dig Dis Sci 1993; 38 (5): 916–22.
50. Gluud LL, Vilstrup H, Morgan MY. Nonabsorbable disaccharides for hepatic encephalopathy: A systematic review and meta-analysis. Hepatology 2016; 64 (3): 908–22.
2. Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol 2011; 106 (9): 1582–91.
3. Choung RS, Locke GR 3rd, Schleck CD et al. Cumulative incidence of chronic constipation: a population-based study 1988–2003. Aliment Pharmacol Ther 2007; 26 (11–12): 1521–8.
4. Prilepskaia S.I., Parfenov A.I., Lazebnik L.B. Rasprostranennost' i faktory riska zaporov u vzroslogo naseleniia Moskvy po dannym populiatsionnogo issledovaniia «MUZA». Eksperim. i klin. gastroenterologiia. 2011; 3: 68–73. [in Russian]
5. Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 2010; 31: 938–49.
6. Dennison C, Prasad M, Lloyd A et al. The health-related quality of life and economic burden of constipation. Pharmacoeconomics 2005; 23: 461–76.
7. Johanson IF, Kralsteln J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007; 25: 599–608.
8. Samsonov A.A., Kucheriavyi Iu.A., Andreev D.N. Khronicheskii zapor: problemy terapii. Vrach. 2011; 4: 24–9. [in Russian]
9. Gwee KA, Ghoshal UC, Gonlachanvit S et al. Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool. J Neurogastroenterol Motil 2013; 19 (2): 149–60.
10. Lacy BE, Levenick JM, Crowell M. Chronic constipation: new diagnostic and treatment approaches. Ther Adv Gastroenterol 2012; 5 (4): 233–47.
11. Andreev D.N., Zaborovskii A.V., Trukhmanov A.S. i dr. Evoliutsiia predstavlenii o funktsional'nykh zabolevaniiakh zheludochno-kishechnogo trakta v svete Rimskikh kriteriev IV peresmotra (2016 g.). RZhGGK. 2017; 1: 4–11. [in Russian]
12. Lacy BE, Mearin F, Chang L et al. Bowel Disorders. Gastroenterology 2016; 150: 1393–1407.
13. Cheremushkin S., Kucheriavyi Iu. Dokazatel'naia meditsina i lechenie khronicheskogo zapora. Vrach. 2012; 10: 42–7. [in Russian]
14. Maev I.V., Dicheva D.T., Andreev D.N. Novye vozmozhnosti lecheniia khronicheskogo zapora. Vrach. 2012; 3: 45–7. [in Russian]
15. Maev I.V., Samsonov A.A., Dicheva D.T., Andreev D.N. Obstipatsionnyi sindrom. Meditsinskii vestnik MVD. 2012; 4: 42–5. [in Russian]
16. De Schryver AM, Keulemans YC, Peters HP et al. Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation. Scand J Gastroenterol 2005; 40: 422–9.
17. Dukas L, Willett WC, Giovannucci EL. Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol 2003; 98: 1790–6;
18. Ashraf W, Park F, Lof J, Quigley EM. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther 1995; 9: 639–47.
19. Ivashkin V.T., Maev I.V., Sheptulin A.A. i dr. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu vzroslykh patsientov s khronicheskim zaporom. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2017; 27 (3): 75–83. [in Russian]
20. Maevskaia E.A. Khronicheskii zapor: taktika vedeniia na osnove nauchnykh faktov. Farmateka. 2014; 14: 17–23. [in Russian]
21. Maev I.V., Samsonov A.A., Andreev D.N. Sovremennyi algoritm vedeniia patsientov s sindromom khronicheskogo zapora s pozitsii vnedreniia novykh farmakologicheskikh preparatov. Farmateka. 2012; 13 (246): 37–43. [in Russian]
22. Mueller-Lissner S, Kamm MA, Wald A et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol 2010; 105: 897–903.
23. Kamm MA, Mueller-Lissner S, Wald A et al. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol 2011; 9: 577–83.
24. Maev I.V., Andreev D.N., Dicheva D.T., Gurtovenko I.Iu. Risk dlitel'nogo primeneniia slabitel'nykh preparatov. Vrach. 2014; 1: 26–30. [in Russian]
25. Badiali D, Marcheggiano A, Pallone F et al. Melanosis of the rectum in patients with chronic constipation. Dis Colon Rectum 1985; 28: 241–5.
26. Stanghellini V, Vandeplassche L, Kerstens R. Best response distribution of 12-week treatment with prucalopride (RESOLOR) in patients with chronic constipation: combined results of three randomized, double-blind, placebo-controlled phase III trials. Gut 2011; 60 (Suppl. 1): A159–A160.
27. Tack J, Müller-Lissner S. Treatment of chronic constipation: current pharmacologic approaches and future directions. Clin Gastroenterol Hepatol 2009; 7: 502–8.
28. Khronicheskii zapor: metod. rekomendatsii GBUZ MKNTs i TsNIIG. M.: Prima Print, 2016. [in Russian]
29. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL. Lactulose versus polyethylene glycol for chronic constipation. Cochrane Database Syst Rev 2010; 7: CD007570.
30. Gordon M, Naidoo K, Akobeng AK, Thomas AG. Cochrane Review: Osmotic and stimulant laxatives for the management of childhoodconstipation (Review). Evid Based Child Health 2013; 8 (1): 57–109.
31. Corazziari E, Badiali D, Habib FI et al. Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation. Dig Dis Sci 1996; 41: 1636–42.
32. Minushkin O.N. Eshche raz o vybore slabitel'nykh preparatov pri funktsional'nykh zaporakh. Effektivnaia farmakoterapiia. Gastroenterologiia. 2013; 17: 12–8. [in Russian]
33. Schiller LR. Review article: the therapy of constipation. Aliment Pharmacol Ther 2001; 15 (6): 749–63.
34. Greer JB, O'Keefe SJ. Microbial induction of immunity, inflammation, and cancer. Front Physiol 2011; 1: 168.
35. Illanes A, Guerrero C, Vera C et al. Lactose-Derived Prebiotics: A Process Perspective. UK, 2016.
36. Wright RA. Lactulose-induced megacolon. Gastrointest Endosc 1988; 34: 489–90.
37. Faruqui AA, Joshi C. Lactitol: a review of its use in the treatment of constipation. Int J Recent Adv Pharm Res 2012; 2 (1): 1–5.
38. Maydeo A. Lactitol or lactulose in the treatment of chronic constipation: result of a systematic. J Indian Med Assoc 2010; 108 (11): 789–92.
39. Chen C, Li L, Wu Z et al. Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. J Infect 2007; 54 (1): 98–102.
40. Minushkin O.N., Ardatskaia M.D., Elizavetina G.A. i dr. Funktsional'nye zapory: nekotorye lechebnye podkhody. Effektivnaia farmakoterapiia. Gastroenterologiia. 2011; 3: 9–13. [in Russian]
41. Miller LE, Tennilä J, Ouwehand AC. Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis. Clin Exp Gastroenterol 2014; 7: 241–8.
42. Xu Z, Dai J, Shi R et al. A multicenter, randomized, single-blinded, parallel-controlled trial on lactitol in treatment of constipation. Chin J Gastroenterology 2012; 17 (3): 168–72.
43. Doffoel M, Berthel M, Bockel R et al. Comparative study of lactitol and lactulose in the treatment of functional constipation in elderly subjects. Medecine Chirurgie Digestives (Paris) 1990; 19 (4): 257–9.
44. Hammer B, Ravelli GP. Chronic functional constipation: lactitol maintenance dose, a multicentre comparative study with lactulose. Ther Schweiz 1992; 8: 328–35.
45. Heitland W, Mauersberger H. A clinical investigation comparing the laxative effect of lactitol to that of lactulose in a randomised, open, parallel study. Schweiz Rundsch Med Prax 1988; 77 (18): 493–5.
46. Minushkin O.N., Ardatskaia M.D., Voskoboinikova I.V., Kolkhir V.K. Eksportal (Laktitol) – effektivnoe i bezopasnoe osmoticheskoe slabitel'noe. RZhGGK. 2010; 5S36: 118. [in Russian]
47. Pitzalis G, Deganello F, Mariani P et al. Lactitol in chronic idiopathic constipation in children. Pediatr Med Chir 1995; 17 (3): 223–6.
48. Santhosh KM, Jagadeesh K, Shreenivas PR. Clinical efficacy and safety of lactitol versus lactulose in the treatment of constipation. Int J Institut Pharm Life Sci 2015; 5 (2): 265–71.
49. Cammà C, Fiorello F, Tinè F et al. Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis. Dig Dis Sci 1993; 38 (5): 916–22.
50. Gluud LL, Vilstrup H, Morgan MY. Nonabsorbable disaccharides for hepatic encephalopathy: A systematic review and meta-analysis. Hepatology 2016; 64 (3): 908–22.
2. Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol 2011; 106 (9): 1582–91.
3. Choung RS, Locke GR 3rd, Schleck CD et al. Cumulative incidence of chronic constipation: a population-based study 1988–2003. Aliment Pharmacol Ther 2007; 26 (11–12): 1521–8.
4. Прилепская С.И., Парфенов А.И., Лазебник Л.Б. Распространенность и факторы риска запоров у взрослого населения Москвы по данным популяционного исследования «МУЗА». Эксперим. и клин. гастроэнтерология. 2011; 3: 68–73. / Prilepskaia S.I., Parfenov A.I., Lazebnik L.B. Rasprostranennost' i faktory riska zaporov u vzroslogo naseleniia Moskvy po dannym populiatsionnogo issledovaniia «MUZA». Eksperim. i klin. gastroenterologiia. 2011; 3: 68–73. [in Russian]
5. Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 2010; 31: 938–49.
6. Dennison C, Prasad M, Lloyd A et al. The health-related quality of life and economic burden of constipation. Pharmacoeconomics 2005; 23: 461–76.
7. Johanson IF, Kralsteln J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007; 25: 599–608.
8. Самсонов А.А., Кучерявый Ю.А., Андреев Д.Н. Хронический запор: проблемы терапии. Врач. 2011; 4: 24–9. / Samsonov A.A., Kucheriavyi Iu.A., Andreev D.N. Khronicheskii zapor: problemy terapii. Vrach. 2011; 4: 24–9. [in Russian]
9. Gwee KA, Ghoshal UC, Gonlachanvit S et al. Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool. J Neurogastroenterol Motil 2013; 19 (2): 149–60.
10. Lacy BE, Levenick JM, Crowell M. Chronic constipation: new diagnostic and treatment approaches. Ther Adv Gastroenterol 2012; 5 (4): 233–47.
11. Андреев Д.Н., Заборовский А.В., Трухманов А.С. и др. Эволюция представлений о функциональных заболеваниях желудочно-кишечного тракта в свете Римских критериев IV пересмотра (2016 г.). РЖГГК. 2017; 1: 4–11. / Andreev D.N., Zaborovskii A.V., Trukhmanov A.S. i dr. Evoliutsiia predstavlenii o funktsional'nykh zabolevaniiakh zheludochno-kishechnogo trakta v svete Rimskikh kriteriev IV peresmotra (2016 g.). RZhGGK. 2017; 1: 4–11. [in Russian]
12. Lacy BE, Mearin F, Chang L et al. Bowel Disorders. Gastroenterology 2016; 150: 1393–1407.
13. Черемушкин С., Кучерявый Ю. Доказательная медицина и лечение хронического запора. Врач. 2012; 10: 42–7. / Cheremushkin S., Kucheriavyi Iu. Dokazatel'naia meditsina i lechenie khronicheskogo zapora. Vrach. 2012; 10: 42–7. [in Russian]
14. Маев И.В., Дичева Д.Т., Андреев Д.Н. Новые возможности лечения хронического запора. Врач. 2012; 3: 45–7. / Maev I.V., Dicheva D.T., Andreev D.N. Novye vozmozhnosti lecheniia khronicheskogo zapora. Vrach. 2012; 3: 45–7. [in Russian]
15. Маев И.В., Самсонов А.А., Дичева Д.Т., Андреев Д.Н. Обстипационный синдром. Медицинский вестник МВД. 2012; 4: 42–5. / Maev I.V., Samsonov A.A., Dicheva D.T., Andreev D.N. Obstipatsionnyi sindrom. Meditsinskii vestnik MVD. 2012; 4: 42–5. [in Russian]
16. De Schryver AM, Keulemans YC, Peters HP et al. Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation. Scand J Gastroenterol 2005; 40: 422–9.
17. Dukas L, Willett WC, Giovannucci EL. Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol 2003; 98: 1790–6;
18. Ashraf W, Park F, Lof J, Quigley EM. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther 1995; 9: 639–47.
19. Ивашкин В.Т., Маев И.В., Шептулин А.А. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению взрослых пациентов с хроническим запором. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2017; 27 (3): 75–83. / Ivashkin V.T., Maev I.V., Sheptulin A.A. i dr. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu vzroslykh patsientov s khronicheskim zaporom. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2017; 27 (3): 75–83. [in Russian]
20. Маевская Е.А. Хронический запор: тактика ведения на основе научных фактов. Фарматека. 2014; 14: 17–23. / Maevskaia E.A. Khronicheskii zapor: taktika vedeniia na osnove nauchnykh faktov. Farmateka. 2014; 14: 17–23. [in Russian]
21. Маев И.В., Самсонов А.А., Андреев Д.Н. Современный алгоритм ведения пациентов с синдромом хронического запора с позиций внедрения новых фармакологических препаратов. Фарматека. 2012; 13 (246): 37–43. / Maev I.V., Samsonov A.A., Andreev D.N. Sovremennyi algoritm vedeniia patsientov s sindromom khronicheskogo zapora s pozitsii vnedreniia novykh farmakologicheskikh preparatov. Farmateka. 2012; 13 (246): 37–43. [in Russian]
22. Mueller-Lissner S, Kamm MA, Wald A et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol 2010; 105: 897–903.
23. Kamm MA, Mueller-Lissner S, Wald A et al. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol 2011; 9: 577–83.
24. Маев И.В., Андреев Д.Н., Дичева Д.Т., Гуртовенко И.Ю. Риск длительного применения слабительных препаратов. Врач. 2014; 1: 26–30. / Maev I.V., Andreev D.N., Dicheva D.T., Gurtovenko I.Iu. Risk dlitel'nogo primeneniia slabitel'nykh preparatov. Vrach. 2014; 1: 26–30. [in Russian]
25. Badiali D, Marcheggiano A, Pallone F et al. Melanosis of the rectum in patients with chronic constipation. Dis Colon Rectum 1985; 28: 241–5.
26. Stanghellini V, Vandeplassche L, Kerstens R. Best response distribution of 12-week treatment with prucalopride (RESOLOR) in patients with chronic constipation: combined results of three randomized, double-blind, placebo-controlled phase III trials. Gut 2011; 60 (Suppl. 1): A159–A160.
27. Tack J, Müller-Lissner S. Treatment of chronic constipation: current pharmacologic approaches and future directions. Clin Gastroenterol Hepatol 2009; 7: 502–8.
28. Хронический запор: метод. рекомендации ГБУЗ МКНЦ и ЦНИИГ. М.: Прима Принт, 2016. / Khronicheskii zapor: metod. rekomendatsii GBUZ MKNTs i TsNIIG. M.: Prima Print, 2016. [in Russian]
29. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL. Lactulose versus polyethylene glycol for chronic constipation. Cochrane Database Syst Rev 2010; 7: CD007570.
30. Gordon M, Naidoo K, Akobeng AK, Thomas AG. Cochrane Review: Osmotic and stimulant laxatives for the management of childhoodconstipation (Review). Evid Based Child Health 2013; 8 (1): 57–109.
31. Corazziari E, Badiali D, Habib FI et al. Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation. Dig Dis Sci 1996; 41: 1636–42.
32. Минушкин О.Н. Еще раз о выборе слабительных препаратов при функциональных запорах. Эффективная фармакотерапия. Гастроэнтерология. 2013; 17: 12–8. / Minushkin O.N. Eshche raz o vybore slabitel'nykh preparatov pri funktsional'nykh zaporakh. Effektivnaia farmakoterapiia. Gastroenterologiia. 2013; 17: 12–8. [in Russian]
33. Schiller LR. Review article: the therapy of constipation. Aliment Pharmacol Ther 2001; 15 (6): 749–63.
34. Greer JB, O'Keefe SJ. Microbial induction of immunity, inflammation, and cancer. Front Physiol 2011; 1: 168.
35. Illanes A, Guerrero C, Vera C et al. Lactose-Derived Prebiotics: A Process Perspective. UK, 2016.
36. Wright RA. Lactulose-induced megacolon. Gastrointest Endosc 1988; 34: 489–90.
37. Faruqui AA, Joshi C. Lactitol: a review of its use in the treatment of constipation. Int J Recent Adv Pharm Res 2012; 2 (1): 1–5.
38. Maydeo A. Lactitol or lactulose in the treatment of chronic constipation: result of a systematic. J Indian Med Assoc 2010; 108 (11): 789–92.
39. Chen C, Li L, Wu Z et al. Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. J Infect 2007; 54 (1): 98–102.
40. Минушкин О.Н., Ардатская М.Д., Елизаветина Г.А. и др. Функциональные запоры: некоторые лечебные подходы. Эффективная фармакотерапия. Гастроэнтерология. 2011; 3: 9–13. / Minushkin O.N., Ardatskaia M.D., Elizavetina G.A. i dr. Funktsional'nye zapory: nekotorye lechebnye podkhody. Effektivnaia farmakoterapiia. Gastroenterologiia. 2011; 3: 9–13. [in Russian]
41. Miller LE, Tennilä J, Ouwehand AC. Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis. Clin Exp Gastroenterol 2014; 7: 241–8.
42. Xu Z, Dai J, Shi R et al. A multicenter, randomized, single-blinded, parallel-controlled trial on lactitol in treatment of constipation. Chin J Gastroenterology 2012; 17 (3): 168–72.
43. Doffoel M, Berthel M, Bockel R et al. Comparative study of lactitol and lactulose in the treatment of functional constipation in elderly subjects. Medecine Chirurgie Digestives (Paris) 1990; 19 (4): 257–9.
44. Hammer B, Ravelli GP. Chronic functional constipation: lactitol maintenance dose, a multicentre comparative study with lactulose. Ther Schweiz 1992; 8: 328–35.
45. Heitland W, Mauersberger H. A clinical investigation comparing the laxative effect of lactitol to that of lactulose in a randomised, open, parallel study. Schweiz Rundsch Med Prax 1988; 77 (18): 493–5.
46. Минушкин О.Н., Ардатская М.Д., Воскобойникова И.В., Колхир В.К. Экспортал (Лактитол) – эффективное и безопасное осмотическое слабительное. РЖГГК. 2010; 5S36: 118. / Minushkin O.N., Ardatskaia M.D., Voskoboinikova I.V., Kolkhir V.K. Eksportal (Laktitol) – effektivnoe i bezopasnoe osmoticheskoe slabitel'noe. RZhGGK. 2010; 5S36: 118. [in Russian]
47. Pitzalis G, Deganello F, Mariani P et al. Lactitol in chronic idiopathic constipation in children. Pediatr Med Chir 1995; 17 (3): 223–6.
48. Santhosh KM, Jagadeesh K, Shreenivas PR. Clinical efficacy and safety of lactitol versus lactulose in the treatment of constipation. Int J Institut Pharm Life Sci 2015; 5 (2): 265–71.
49. Cammà C, Fiorello F, Tinè F et al. Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis. Dig Dis Sci 1993; 38 (5): 916–22.
50. Gluud LL, Vilstrup H, Morgan MY. Nonabsorbable disaccharides for hepatic encephalopathy: A systematic review and meta-analysis. Hepatology 2016; 64 (3): 908–22.
________________________________________________
2. Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol 2011; 106 (9): 1582–91.
3. Choung RS, Locke GR 3rd, Schleck CD et al. Cumulative incidence of chronic constipation: a population-based study 1988–2003. Aliment Pharmacol Ther 2007; 26 (11–12): 1521–8.
4. Prilepskaia S.I., Parfenov A.I., Lazebnik L.B. Rasprostranennost' i faktory riska zaporov u vzroslogo naseleniia Moskvy po dannym populiatsionnogo issledovaniia «MUZA». Eksperim. i klin. gastroenterologiia. 2011; 3: 68–73. [in Russian]
5. Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 2010; 31: 938–49.
6. Dennison C, Prasad M, Lloyd A et al. The health-related quality of life and economic burden of constipation. Pharmacoeconomics 2005; 23: 461–76.
7. Johanson IF, Kralsteln J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007; 25: 599–608.
8. Samsonov A.A., Kucheriavyi Iu.A., Andreev D.N. Khronicheskii zapor: problemy terapii. Vrach. 2011; 4: 24–9. [in Russian]
9. Gwee KA, Ghoshal UC, Gonlachanvit S et al. Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool. J Neurogastroenterol Motil 2013; 19 (2): 149–60.
10. Lacy BE, Levenick JM, Crowell M. Chronic constipation: new diagnostic and treatment approaches. Ther Adv Gastroenterol 2012; 5 (4): 233–47.
11. Andreev D.N., Zaborovskii A.V., Trukhmanov A.S. i dr. Evoliutsiia predstavlenii o funktsional'nykh zabolevaniiakh zheludochno-kishechnogo trakta v svete Rimskikh kriteriev IV peresmotra (2016 g.). RZhGGK. 2017; 1: 4–11. [in Russian]
12. Lacy BE, Mearin F, Chang L et al. Bowel Disorders. Gastroenterology 2016; 150: 1393–1407.
13. Cheremushkin S., Kucheriavyi Iu. Dokazatel'naia meditsina i lechenie khronicheskogo zapora. Vrach. 2012; 10: 42–7. [in Russian]
14. Maev I.V., Dicheva D.T., Andreev D.N. Novye vozmozhnosti lecheniia khronicheskogo zapora. Vrach. 2012; 3: 45–7. [in Russian]
15. Maev I.V., Samsonov A.A., Dicheva D.T., Andreev D.N. Obstipatsionnyi sindrom. Meditsinskii vestnik MVD. 2012; 4: 42–5. [in Russian]
16. De Schryver AM, Keulemans YC, Peters HP et al. Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation. Scand J Gastroenterol 2005; 40: 422–9.
17. Dukas L, Willett WC, Giovannucci EL. Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol 2003; 98: 1790–6;
18. Ashraf W, Park F, Lof J, Quigley EM. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther 1995; 9: 639–47.
19. Ivashkin V.T., Maev I.V., Sheptulin A.A. i dr. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu vzroslykh patsientov s khronicheskim zaporom. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2017; 27 (3): 75–83. [in Russian]
20. Maevskaia E.A. Khronicheskii zapor: taktika vedeniia na osnove nauchnykh faktov. Farmateka. 2014; 14: 17–23. [in Russian]
21. Maev I.V., Samsonov A.A., Andreev D.N. Sovremennyi algoritm vedeniia patsientov s sindromom khronicheskogo zapora s pozitsii vnedreniia novykh farmakologicheskikh preparatov. Farmateka. 2012; 13 (246): 37–43. [in Russian]
22. Mueller-Lissner S, Kamm MA, Wald A et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol 2010; 105: 897–903.
23. Kamm MA, Mueller-Lissner S, Wald A et al. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol 2011; 9: 577–83.
24. Maev I.V., Andreev D.N., Dicheva D.T., Gurtovenko I.Iu. Risk dlitel'nogo primeneniia slabitel'nykh preparatov. Vrach. 2014; 1: 26–30. [in Russian]
25. Badiali D, Marcheggiano A, Pallone F et al. Melanosis of the rectum in patients with chronic constipation. Dis Colon Rectum 1985; 28: 241–5.
26. Stanghellini V, Vandeplassche L, Kerstens R. Best response distribution of 12-week treatment with prucalopride (RESOLOR) in patients with chronic constipation: combined results of three randomized, double-blind, placebo-controlled phase III trials. Gut 2011; 60 (Suppl. 1): A159–A160.
27. Tack J, Müller-Lissner S. Treatment of chronic constipation: current pharmacologic approaches and future directions. Clin Gastroenterol Hepatol 2009; 7: 502–8.
28. Khronicheskii zapor: metod. rekomendatsii GBUZ MKNTs i TsNIIG. M.: Prima Print, 2016. [in Russian]
29. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL. Lactulose versus polyethylene glycol for chronic constipation. Cochrane Database Syst Rev 2010; 7: CD007570.
30. Gordon M, Naidoo K, Akobeng AK, Thomas AG. Cochrane Review: Osmotic and stimulant laxatives for the management of childhoodconstipation (Review). Evid Based Child Health 2013; 8 (1): 57–109.
31. Corazziari E, Badiali D, Habib FI et al. Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation. Dig Dis Sci 1996; 41: 1636–42.
32. Minushkin O.N. Eshche raz o vybore slabitel'nykh preparatov pri funktsional'nykh zaporakh. Effektivnaia farmakoterapiia. Gastroenterologiia. 2013; 17: 12–8. [in Russian]
33. Schiller LR. Review article: the therapy of constipation. Aliment Pharmacol Ther 2001; 15 (6): 749–63.
34. Greer JB, O'Keefe SJ. Microbial induction of immunity, inflammation, and cancer. Front Physiol 2011; 1: 168.
35. Illanes A, Guerrero C, Vera C et al. Lactose-Derived Prebiotics: A Process Perspective. UK, 2016.
36. Wright RA. Lactulose-induced megacolon. Gastrointest Endosc 1988; 34: 489–90.
37. Faruqui AA, Joshi C. Lactitol: a review of its use in the treatment of constipation. Int J Recent Adv Pharm Res 2012; 2 (1): 1–5.
38. Maydeo A. Lactitol or lactulose in the treatment of chronic constipation: result of a systematic. J Indian Med Assoc 2010; 108 (11): 789–92.
39. Chen C, Li L, Wu Z et al. Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. J Infect 2007; 54 (1): 98–102.
40. Minushkin O.N., Ardatskaia M.D., Elizavetina G.A. i dr. Funktsional'nye zapory: nekotorye lechebnye podkhody. Effektivnaia farmakoterapiia. Gastroenterologiia. 2011; 3: 9–13. [in Russian]
41. Miller LE, Tennilä J, Ouwehand AC. Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis. Clin Exp Gastroenterol 2014; 7: 241–8.
42. Xu Z, Dai J, Shi R et al. A multicenter, randomized, single-blinded, parallel-controlled trial on lactitol in treatment of constipation. Chin J Gastroenterology 2012; 17 (3): 168–72.
43. Doffoel M, Berthel M, Bockel R et al. Comparative study of lactitol and lactulose in the treatment of functional constipation in elderly subjects. Medecine Chirurgie Digestives (Paris) 1990; 19 (4): 257–9.
44. Hammer B, Ravelli GP. Chronic functional constipation: lactitol maintenance dose, a multicentre comparative study with lactulose. Ther Schweiz 1992; 8: 328–35.
45. Heitland W, Mauersberger H. A clinical investigation comparing the laxative effect of lactitol to that of lactulose in a randomised, open, parallel study. Schweiz Rundsch Med Prax 1988; 77 (18): 493–5.
46. Minushkin O.N., Ardatskaia M.D., Voskoboinikova I.V., Kolkhir V.K. Eksportal (Laktitol) – effektivnoe i bezopasnoe osmoticheskoe slabitel'noe. RZhGGK. 2010; 5S36: 118. [in Russian]
47. Pitzalis G, Deganello F, Mariani P et al. Lactitol in chronic idiopathic constipation in children. Pediatr Med Chir 1995; 17 (3): 223–6.
48. Santhosh KM, Jagadeesh K, Shreenivas PR. Clinical efficacy and safety of lactitol versus lactulose in the treatment of constipation. Int J Institut Pharm Life Sci 2015; 5 (2): 265–71.
49. Cammà C, Fiorello F, Tinè F et al. Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis. Dig Dis Sci 1993; 38 (5): 916–22.
50. Gluud LL, Vilstrup H, Morgan MY. Nonabsorbable disaccharides for hepatic encephalopathy: A systematic review and meta-analysis. Hepatology 2016; 64 (3): 908–22.
Авторы
Ю.А.Кучерявый, Д.Н.Андреев*, С.В.Черемушкин
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр.1
*dna-mit8@mail.ru
A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*dna-mit8@mail.ru
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр.1
*dna-mit8@mail.ru
________________________________________________
A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*dna-mit8@mail.ru
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