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Доброкачественные новообразования кожи у пациентов с псориазом
Доброкачественные новообразования кожи у пациентов с псориазом
Криницына Ю.М., Зубарев А.К., Сергеева И.Г. Доброкачественные новообразования кожи у пациентов с псориазом. Дерматология (Прил. к журн. Consilium Medicum). 2017; 3: 16–19.
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Аннотация
Внедрение дерматоскопии в практику врача и высокая распространенность злокачественных новообразований кожи привели, с одной стороны, к увеличению числа пациентов, обратившихся на осмотр кожных покровов по поводу различных новообразований, с другой – к онкологической настороженности врачей-дерматовенерологов, особенно при оценке состояния кожи пациентов, относящихся к группе повышенного риска (пожилой возраст, множественные ультрафиолетовые облучения в анамнезе, отягощенный семейный анамнез). Методом случайной последовательной выборки были отобраны 126 пациентов среднего (45–59 лет) и пожилого (60–74 лет) возраста, из которых сформировали 4 группы наблюдений в зависимости от возраста и наличия псориаза. Меланоцитарные новообразования кожи у пациентов с псориазом и без псориаза встречались одинаково часто, большинство пограничных и внутридермальных невусов располагалось на коже спины. Эпителиальные новообразования (себорейные кератомы и акрохордоны) у пациентов с псориазом встречали реже, чем в контрольных группах, но среди пациентов с метаболическим синдромом акрохордоны обнаруживали значительно чаще, чем у пациентов без метаболического синдрома. Особенностью кожи пожилых пациентов с псориазом являлась большая частота ангиом. Таким образом, проведенное исследование показало широкую распространенность на коже пациентов с псориазом доброкачественных новообразований меланоцитарной (невусы) и немеланоцитарной (акрохордоны, себорейные кератомы, ангиомы) природы.
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Полный текст
Список литературы
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11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
2. Molochkov V.A. Melanotsitarnye nevusy i profilaktika melanomy. Vrach. 2007; 2: 49–51. [in Russian]
3. Balato NI. Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? British J Dermatology 2011; 164 (Issue 6): 1262–70.
4. Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol 2001; 117 (6): 1531–7.
5. Di Cesare A, Riitano A, Suppa M et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69 (6): 947–53.
6. Kochergin N.G. Psoriaz: poslednie novosti. Dermatologiia. 2007; 2: 14–17. [in Russian]
7. Olisova O.Iu. Psoriaz: epidemiologiia, patogenez, klinika, lechenie. Dermatologiia. 2010; 4: 3–8. [in Russian]
8. Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44 (5): 755–61.
9. Persad P, Levender MM, Feldman SR. Commentary: psoriasis patients with a history of malignancy represent an important but overlooked study population. Dermatol Online J 2011; 17 (2): 10.
10. Bridgit VN, Brad AY, Steven RF. A review of home phototherapy for psoriasis. Dermatol Online J 2010; 16 (2).
11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
2. Молочков В.А. Меланоцитарные невусы и профилактика меланомы. Врач. 2007; 2: 49–51. / Molochkov V.A. Melanotsitarnye nevusy i profilaktika melanomy. Vrach. 2007; 2: 49–51. [in Russian]
3. Balato NI. Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? British J Dermatology 2011; 164 (Issue 6): 1262–70.
4. Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol 2001; 117 (6): 1531–7.
5. Di Cesare A, Riitano A, Suppa M et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69 (6): 947–53.
6. Кочергин Н.Г. Псориаз: последние новости. Дерматология. 2007; 2: 14–17. / Kochergin N.G. Psoriaz: poslednie novosti. Dermatologiia. 2007; 2: 14–17. [in Russian]
7. Олисова О.Ю. Псориаз: эпидемиология, патогенез, клиника, лечение. Дерматология. 2010; 4: 3–8. / Olisova O.Iu. Psoriaz: epidemiologiia, patogenez, klinika, lechenie. Dermatologiia. 2010; 4: 3–8. [in Russian]
8. Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44 (5): 755–61.
9. Persad P, Levender MM, Feldman SR. Commentary: psoriasis patients with a history of malignancy represent an important but overlooked study population. Dermatol Online J 2011; 17 (2): 10.
10. Bridgit VN, Brad AY, Steven RF. A review of home phototherapy for psoriasis. Dermatol Online J 2010; 16 (2).
11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
________________________________________________
2. Molochkov V.A. Melanotsitarnye nevusy i profilaktika melanomy. Vrach. 2007; 2: 49–51. [in Russian]
3. Balato NI. Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? British J Dermatology 2011; 164 (Issue 6): 1262–70.
4. Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol 2001; 117 (6): 1531–7.
5. Di Cesare A, Riitano A, Suppa M et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69 (6): 947–53.
6. Kochergin N.G. Psoriaz: poslednie novosti. Dermatologiia. 2007; 2: 14–17. [in Russian]
7. Olisova O.Iu. Psoriaz: epidemiologiia, patogenez, klinika, lechenie. Dermatologiia. 2010; 4: 3–8. [in Russian]
8. Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44 (5): 755–61.
9. Persad P, Levender MM, Feldman SR. Commentary: psoriasis patients with a history of malignancy represent an important but overlooked study population. Dermatol Online J 2011; 17 (2): 10.
10. Bridgit VN, Brad AY, Steven RF. A review of home phototherapy for psoriasis. Dermatol Online J 2010; 16 (2).
11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
Авторы
Ю.М.Криницына1,2, А.К.Зубарев1, И.Г.Сергеева*1
1. ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет». 630090, Россия, Новосибирск, ул. Пирогова, д. 1;
2. ФГБНУ «Институт молекулярной патологии и патоморфологии». 630117, Россия, Новосибирск, ул. Тимакова, д. 2
*i_g_sergeeva@mail.ru
1. Novosibirsk National Research State University.
630090, Russian Federation, Novosibirsk, ul. Pirogova, d. 1;
2. Institute of Molecular Pathology and Pathomorphology. 630117, Russian Federation, Novosibirsk, ul. Timakova, d. 2
*i_g_sergeeva@mail.ru
1. ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет». 630090, Россия, Новосибирск, ул. Пирогова, д. 1;
2. ФГБНУ «Институт молекулярной патологии и патоморфологии». 630117, Россия, Новосибирск, ул. Тимакова, д. 2
*i_g_sergeeva@mail.ru
________________________________________________
1. Novosibirsk National Research State University.
630090, Russian Federation, Novosibirsk, ul. Pirogova, d. 1;
2. Institute of Molecular Pathology and Pathomorphology. 630117, Russian Federation, Novosibirsk, ul. Timakova, d. 2
*i_g_sergeeva@mail.ru
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