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Доброкачественные новообразования кожи у пациентов с псориазом
Криницына Ю.М., Зубарев А.К., Сергеева И.Г. Доброкачественные новообразования кожи у пациентов с псориазом. Дерматология (Прил. к журн. Consilium Medicum). 2017; 3: 16–19.
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Krinicyna Yu.M., Zubarev A.K., Sergeeva I.G. Benign skin lesions in patients with psoriasis. Dermatology (Suppl. Consilium Medicum). 2017; 3: 16–19.
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Аннотация
Внедрение дерматоскопии в практику врача и высокая распространенность злокачественных новообразований кожи привели, с одной стороны, к увеличению числа пациентов, обратившихся на осмотр кожных покровов по поводу различных новообразований, с другой – к онкологической настороженности врачей-дерматовенерологов, особенно при оценке состояния кожи пациентов, относящихся к группе повышенного риска (пожилой возраст, множественные ультрафиолетовые облучения в анамнезе, отягощенный семейный анамнез). Методом случайной последовательной выборки были отобраны 126 пациентов среднего (45–59 лет) и пожилого (60–74 лет) возраста, из которых сформировали 4 группы наблюдений в зависимости от возраста и наличия псориаза. Меланоцитарные новообразования кожи у пациентов с псориазом и без псориаза встречались одинаково часто, большинство пограничных и внутридермальных невусов располагалось на коже спины. Эпителиальные новообразования (себорейные кератомы и акрохордоны) у пациентов с псориазом встречали реже, чем в контрольных группах, но среди пациентов с метаболическим синдромом акрохордоны обнаруживали значительно чаще, чем у пациентов без метаболического синдрома. Особенностью кожи пожилых пациентов с псориазом являлась большая частота ангиом. Таким образом, проведенное исследование показало широкую распространенность на коже пациентов с псориазом доброкачественных новообразований меланоцитарной (невусы) и немеланоцитарной (акрохордоны, себорейные кератомы, ангиомы) природы.
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The introduction of dermoscopy into the practice of a doctor and the high prevalence of malignant neoplasm of skin led, on the one hand, to an increase in the number of patients who examined the skin for various neoplasms, and on the other – to oncological alertness of dermatologists, especially during assessing the skin condition of patients from the high-risk group (old age, multiple ultraviolet exposures in history, aggravated family history). Using random sequential sampling method we selected 126 patients of middle age (45–59 years) and elderly (60–74 years) age, from which we formed 4 groups of observations depending on the age and the presence of psoriasis. Melanocytic neoplasms of the skin in patients with psoriasis and without psoriasis were met equally often, most borderline and intradermal nevi were located on the skin of the back. Epithelial neoplasms (seborrheic keratomas and acrochordones) were observed less in patients with psoriasis compared with control groups, but among patients with metabolic syndrome acrochordones were detected significantly more often than in patients without metabolic syndrome. A feature of the skin of elderly patients with psoriasis was a high incidence of angiomas. Thus, the conducted study showed a wide prevalence on the skin of patients with psoriasis of benign neoplasms of melanocytic (nevi) and non-melanocytic (acrochordons, seborrheic keratomas, angiomas) origin.
Полный текст
Список литературы
1. Maiorino A, De Simone C, Perino F et al. Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy. J Dermatological Treatment [serial online]. 2016; 27 (5): 443–7.
2. Молочков В.А. Меланоцитарные невусы и профилактика меланомы. Врач. 2007; 2: 49–51. / Molochkov V.A. Melanotsitarnye nevusy i profilaktika melanomy. Vrach. 2007; 2: 49–51. [in Russian]
3. Balato NI. Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? British J Dermatology 2011; 164 (Issue 6): 1262–70.
4. Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol 2001; 117 (6): 1531–7.
5. Di Cesare A, Riitano A, Suppa M et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69 (6): 947–53.
6. Кочергин Н.Г. Псориаз: последние новости. Дерматология. 2007; 2: 14–17. / Kochergin N.G. Psoriaz: poslednie novosti. Dermatologiia. 2007; 2: 14–17. [in Russian]
7. Олисова О.Ю. Псориаз: эпидемиология, патогенез, клиника, лечение. Дерматология. 2010; 4: 3–8. / Olisova O.Iu. Psoriaz: epidemiologiia, patogenez, klinika, lechenie. Dermatologiia. 2010; 4: 3–8. [in Russian]
8. Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44 (5): 755–61.
9. Persad P, Levender MM, Feldman SR. Commentary: psoriasis patients with a history of malignancy represent an important but overlooked study population. Dermatol Online J 2011; 17 (2): 10.
10. Bridgit VN, Brad AY, Steven RF. A review of home phototherapy for psoriasis. Dermatol Online J 2010; 16 (2).
11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
2. Молочков В.А. Меланоцитарные невусы и профилактика меланомы. Врач. 2007; 2: 49–51. / Molochkov V.A. Melanotsitarnye nevusy i profilaktika melanomy. Vrach. 2007; 2: 49–51. [in Russian]
3. Balato NI. Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? British J Dermatology 2011; 164 (Issue 6): 1262–70.
4. Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol 2001; 117 (6): 1531–7.
5. Di Cesare A, Riitano A, Suppa M et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69 (6): 947–53.
6. Кочергин Н.Г. Псориаз: последние новости. Дерматология. 2007; 2: 14–17. / Kochergin N.G. Psoriaz: poslednie novosti. Dermatologiia. 2007; 2: 14–17. [in Russian]
7. Олисова О.Ю. Псориаз: эпидемиология, патогенез, клиника, лечение. Дерматология. 2010; 4: 3–8. / Olisova O.Iu. Psoriaz: epidemiologiia, patogenez, klinika, lechenie. Dermatologiia. 2010; 4: 3–8. [in Russian]
8. Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44 (5): 755–61.
9. Persad P, Levender MM, Feldman SR. Commentary: psoriasis patients with a history of malignancy represent an important but overlooked study population. Dermatol Online J 2011; 17 (2): 10.
10. Bridgit VN, Brad AY, Steven RF. A review of home phototherapy for psoriasis. Dermatol Online J 2010; 16 (2).
11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
________________________________________________
1. Maiorino A, De Simone C, Perino F et al. Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy. J Dermatological Treatment [serial online]. 2016; 27 (5): 443–7.
2. Molochkov V.A. Melanotsitarnye nevusy i profilaktika melanomy. Vrach. 2007; 2: 49–51. [in Russian]
3. Balato NI. Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? British J Dermatology 2011; 164 (Issue 6): 1262–70.
4. Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol 2001; 117 (6): 1531–7.
5. Di Cesare A, Riitano A, Suppa M et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69 (6): 947–53.
6. Kochergin N.G. Psoriaz: poslednie novosti. Dermatologiia. 2007; 2: 14–17. [in Russian]
7. Olisova O.Iu. Psoriaz: epidemiologiia, patogenez, klinika, lechenie. Dermatologiia. 2010; 4: 3–8. [in Russian]
8. Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44 (5): 755–61.
9. Persad P, Levender MM, Feldman SR. Commentary: psoriasis patients with a history of malignancy represent an important but overlooked study population. Dermatol Online J 2011; 17 (2): 10.
10. Bridgit VN, Brad AY, Steven RF. A review of home phototherapy for psoriasis. Dermatol Online J 2010; 16 (2).
11. Criscito M, Stein J. The selfie skin examination. J American Academy Dermatology [serial online] 2016; 74 (6): e123–e125.
12. Girisha BS, Kamath D, Shrinath P, Harish PS. Seborrheic keratosis; A rare case of conductive deafness. JCDR 2012; 6: 913–4.
13. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Elsevier, 2009.
14. Ahmed S, Khan AK, Hasan M, Jamal AB. A huge acrochordon in labia majora – An unusual presentation. Bangladesh Med Res Counc Bull 2011; 37: 110–11.
15. Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol 2012; 22 (1): 106–10.
16. Abdou AG, Maraee AH, Antar AG, Fareed S. Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 2014; 36 (4): 222–30.
17. Panza F, Solfrizzi V, Logroscino G et al. Current epidemiological approaches to the metabolic-cognitive syndrome. J Alzheimers Dis 2012; 30 (Suppl. 2): S31–75.
18. Wolska K, Michalska-Jakubus M, Pietrzak A, Krasowska D. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski 2014; 36 (213): 215–9.
19. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case-control study. Ann Med Health Sci Res 2014; 4 (2): 202–5.
20. El Safoury OS, Abdel Hay RM et al. Skin tags, leptin, metabolic syndrome and change of the life style. Indian J Dermatol Venereol Leprol 2011; 77 (5): 577–80.
21. Cohen AD, Cagnano E, Vardy DA. Cherry angiomas associated with exposure to bromides. Dermatology 2001; 202: 52–3.
22. Nakashima T, Jinnin M, Etoh T et al. Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One 2010; 5(12): e14334.
Авторы
Ю.М.Криницына1,2, А.К.Зубарев1, И.Г.Сергеева*1
1. ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет». 630090, Россия, Новосибирск, ул. Пирогова, д. 1;
2. ФГБНУ «Институт молекулярной патологии и патоморфологии». 630117, Россия, Новосибирск, ул. Тимакова, д. 2
*i_g_sergeeva@mail.ru
1. ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет». 630090, Россия, Новосибирск, ул. Пирогова, д. 1;
2. ФГБНУ «Институт молекулярной патологии и патоморфологии». 630117, Россия, Новосибирск, ул. Тимакова, д. 2
*i_g_sergeeva@mail.ru
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Yu.M.Krinicyna1,2, A.K.Zubarev1, I.G.Sergeeva*1
1. Novosibirsk National Research State University.
630090, Russian Federation, Novosibirsk, ul. Pirogova, d. 1;
2. Institute of Molecular Pathology and Pathomorphology. 630117, Russian Federation, Novosibirsk, ul. Timakova, d. 2
*i_g_sergeeva@mail.ru
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