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        • Место фиксированной комбинации периндоприла и бисопролола в лечении сердечно-сосудистых заболеваний

        Место фиксированной комбинации периндоприла и бисопролола в лечении сердечно-сосудистых заболеваний

        Барышникова Г.А., Чорбинская С.А., Степанова И.И., Блохина О.Е. Место фиксированной комбинации периндоприла и бисопролола в лечении сердечно-сосудистых заболеваний. Consilium Medicum. 2018; 20 (10): 65–71. DOI: 10.26442/2075-1753_2018.10.65-71

        ________________________________________________

        Baryshnikova G.A., Chorbinskaya S.A., Stepanova I.I., Blohina O.E. Fixed combination of perindopril and bisoprolol in cardiovascular disease treatment. Consilium Medicum. 2018; 20 (10): 65–71. DOI: 10.26442/2075-1753_2018.10.65-71

        Место фиксированной комбинации периндоприла и бисопролола в лечении сердечно-сосудистых заболеваний

        Барышникова Г.А., Чорбинская С.А., Степанова И.И., Блохина О.Е. Место фиксированной комбинации периндоприла и бисопролола в лечении сердечно-сосудистых заболеваний. Consilium Medicum. 2018; 20 (10): 65–71. DOI: 10.26442/2075-1753_2018.10.65-71

        ________________________________________________

        Baryshnikova G.A., Chorbinskaya S.A., Stepanova I.I., Blohina O.E. Fixed combination of perindopril and bisoprolol in cardiovascular disease treatment. Consilium Medicum. 2018; 20 (10): 65–71. DOI: 10.26442/2075-1753_2018.10.65-71

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          Место фиксированной комбинации периндоприла и бисопролола в лечении сердечно-сосудистых заболеваний

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        • Аннотация
        • Полный текст
        • Список литературы
        • Авторы
        Аннотация
        В обзоре предоставлена информация о фиксированной комбинации b-адреноблокатора бисопролола и ингибитора ангиотензинпревращающего фермента периндоприла. Подробно рассмотрены достоинства каждого из препаратов, вошедших в препарат Престилол, механизм действия, органопротективные эффекты и влияние на прогноз. Рассмотрены также клинические ситуации, в которых использование подобной фиксированной комбинации окажется наиболее оптимальным и эффективным.

        Ключевые слова: артериальная гипертензия, комбинированная антигипертензивная терапия, фиксированная комбинация, бисопролол, периндоприл, Престилол.

        ________________________________________________

        The review presents information on fixed combination of b-adrenoblocker bisoprolol and angiotensin-converting enzyme inhibitor perindopril. Advantages of each drug included in Prestilol, its mechanism of action, organo-protective effect and prognosis influence are reviewed in detail. Also we discuss clinical cases where use of such fixed combination is more optimal and effective.

        Key words: arterial hypertension, combined antihypertensive therapy, fixed combination, bisoprolol, perindopril, Prestilol. 

        Полный текст

        Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.

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        ________________________________________________

        1. Global Burden of Disease Study 2013 Collaborators. Lancet 2015; 386 (9995): 743–800.
        2. Law MR, Wald NJ, Morris JK, Jordan RE. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003; 326: 1427–35.
        3. Wald DS, Law M, Morris JK et al. Combination therapy vs. monotherapy in reducing blood pressure: meta-analysis on 11 000 participants from 42 trials. Am J Med 2009; 122: 290–300.
        4. Gradman AH, Basile JN, Carter BL, Bakris GL. American Society of Hypertension Writing Group (2010) Combination therapy in hypertension. J Am Soc Hypertens 2010; 4: 42–50.
        5. Liou YS, Ma T, Tien L et al. The relationship between antihypertensive combination therapies comprising diuretics and/or beta-blockers and the risk of new-onset diabetes: a retrospective longitudinal cohort study. Hypertens Res 2009; 32 (6): 496–9.
        6. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31 (7): 1281–357.
        7. Fung V, Huang J, Brand R. Hypertension treatment in a medicare population: adherence and systolic blood pressure control. Clin Ther 2007; 29: 972–84.
        8. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007; 120: 713–9.
        9. Weber MA, Schiffrin EL, White WB et al. Clinical Practice Guidelines for Management of Hyperyension in the Community. О Clin Hypertension 2014; 16 (1): 14–26.
        10. Egan BM, Bandyopadhyay D, Shaftman SR et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension 2012; 59 (6): 1124–31.
        11. Thorin E, Thorin-Trescases N. Vascular endothelial ageing, heartbeat after heartbeat. Cardiovasc Res 2009; 84 (1): 24–32.
        12. Degaute JP, Leeman M, Desert P. Long-term acceptability of perindopril: European multicenter trial on 856 patients. Am J Med 1992; 92 (Suppl. 4B): 84–90.
        13. Speirs C, Wagniart F, Poggi L. Perindopril postmarketing surveillance: a 12 month study in 47 351 hypertensive patients. Brit J Clin Pharmacol 1998; 46: 63–70.
        14. Myers MG. A dose-response study of perindopril in hypertension: effects on blood pressure 6 and 24 h after dosing. Can J Cardiology 1996; 12: 1191–6.
        15. Tsoukas G, Anand S, Yang K. CONFIDENCE Investigators. Dose-dependent antihypertensive efficacy and tolerability of perindopril in a large, observational, 12-week, general practice-based study. Am J Cardiovasc Drug 2011; 11 (1): 45–55.
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        Авторы
        Г.А.Барышникова*, С.А.Чорбинская, И.И.Степанова, О.Е.Блохина

        ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФ. 121359, Россия, Москва, ул. Маршала Тимошенко, д. 21
        *bargalan@mail.ru


        ________________________________________________

        G.A.Baryshnikova*, S.A.Chorbinskaya, I.I.Stepanova, O.E.Blohina

        Central State Medical Academy of the President of the Russian Federation. 121359, Russian Federation, Moscow, ul. Timoshenko, d. 21
        *bargalan@mail.ru 



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