Обзор последних данных рандомизированных исследований, метаанализов и экспериментальных работ, доказывающих эффективность применения триметазидина при сердечно-сосудистых заболеваниях и коморбидной патологии.
Review of the latest data of randomized studies, meta-analyses and experimental studies proving the effectiveness of trimetazidine in cardiovascular diseases and comorbid pathology.
1. Tritto I, Wang Pe, Kuppusamy P. The Anti-Anginal Drug Trimetazidine Reduces Neutrophil-Mediated Cardiac Reperfusion Injury. Cardiovasc Pharmacol 2015; 46 (1): 89–98.
2. Jeong Su Kim, Chang Hoon Kim, Kook Jin Chun. Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry. Clin Res Cardiol. DOI 10.1007/s00392-013-0611-0
3. Szwed H, Sadowski Z, Elikowski W. Combination treatment in stable effort angina using trimetazidine and metoprolol Results of a randomized, double-blind, multicentre study (TRIMPOL II). Eur Heart J 2011; 22: 2267–74.
4. Song Peng, Min Zhao, Jing Wan. The efficacy of trimetazidine on stable angina pectoris: A meta-analysis of randomized clinical trials. Int J Cardiol 2014; 177: 780–5.
5. Kyoung-Ha Park, Woo Jung Park, Min-Kyu Kim. Effects of Trimetazidine on Endothelial Dysfunction After Sheath Injury of Radial Artery 2010 Elsevier Inc. Am J Cardiol 2010; 105: 1723–7.
6. Jinsong Chen, Shanshan Zhou, Jing Jin. Chronic treatment with trimetazidine after discharge reduces the incidence of restenosis in patients who received coronary stent implantation: A 1-year prospective follow-up study. DOI: 10.3892/mmr.2016.5773
7. Glezer MG, Vygodin VA. Anti-Anginal Effectiveness and Tolerability of Trimetazidine Modified Release 80 Mg Once Daily in Stable Angina Patients in Real-World Practice. On behalf of ODA investigators. Adv Ther. https://doi.org/10.1007/s12325-018-0756-3//
8. Dedkova EN, Seidlmayer LK, Blatter LA. Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. J Mol Cell Cardiol 2013. pii: S0022-2828(13)00054-0. DOI: 10.1016/j.yjmcc.2013.01.016
9. Belardinelli R, Solenghi M, Volpe L. Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect. Online publish-ahead-of-print 24 April 2007.
10. Fragasso G, Rosano G, Baek SH. Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: Results from an international multicentre retrospective cohort study. Int J Cardiol 2012. http://dx.doi.org/10.1016/j.ijcard.2012.09.123
11. Dengfeng Gao, Ning Ning, Xiaolin Niu. Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart 2011; 97: 278–86.
12. Lei Zhang, Yizhou Lu, Hong Jiang. Additional Use of Trimetazidine in Patients With Chronic Heart Failure A Meta-Analysis. J Am Col Cardiol 2012; 59 (10).
13. Xiaohan Xu, Weijun Zhang, Yujie Zhou. Effect of Trimetazidine on Recurrent Angina Pectoris and Left Ventricular Structure in Elderly Multivessel Coronary Heart Disease Patients with Diabetes Mellitus After Drug-Eluting Stent Implantation: A Single-Centre, Prospective, Randomized, Double-Blind Study at 2-Year Follow-Up. Springer International Publishing Switzerland 2014. Clin Drug Invest. DOI 10.1007/s40261-014-0170-9
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1. Tritto I, Wang Pe, Kuppusamy P. The Anti-Anginal Drug Trimetazidine Reduces Neutrophil-Mediated Cardiac Reperfusion Injury. Cardiovasc Pharmacol 2015; 46 (1): 89–98.
2. Jeong Su Kim, Chang Hoon Kim, Kook Jin Chun. Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry. Clin Res Cardiol. DOI 10.1007/s00392-013-0611-0
3. Szwed H, Sadowski Z, Elikowski W. Combination treatment in stable effort angina using trimetazidine and metoprolol Results of a randomized, double-blind, multicentre study (TRIMPOL II). Eur Heart J 2011; 22: 2267–74.
4. Song Peng, Min Zhao, Jing Wan. The efficacy of trimetazidine on stable angina pectoris: A meta-analysis of randomized clinical trials. Int J Cardiol 2014; 177: 780–5.
5. Kyoung-Ha Park, Woo Jung Park, Min-Kyu Kim. Effects of Trimetazidine on Endothelial Dysfunction After Sheath Injury of Radial Artery 2010 Elsevier Inc. Am J Cardiol 2010; 105: 1723–7.
6. Jinsong Chen, Shanshan Zhou, Jing Jin. Chronic treatment with trimetazidine after discharge reduces the incidence of restenosis in patients who received coronary stent implantation: A 1-year prospective follow-up study. DOI: 10.3892/mmr.2016.5773
7. Glezer MG, Vygodin VA. Anti-Anginal Effectiveness and Tolerability of Trimetazidine Modified Release 80 Mg Once Daily in Stable Angina Patients in Real-World Practice. On behalf of ODA investigators. Adv Ther. https://doi.org/10.1007/s12325-018-0756-3//
8. Dedkova EN, Seidlmayer LK, Blatter LA. Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. J Mol Cell Cardiol 2013. pii: S0022-2828(13)00054-0. DOI: 10.1016/j.yjmcc.2013.01.016
9. Belardinelli R, Solenghi M, Volpe L. Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect. Online publish-ahead-of-print 24 April 2007.
10. Fragasso G, Rosano G, Baek SH. Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: Results from an international multicentre retrospective cohort study. Int J Cardiol 2012. http://dx.doi.org/10.1016/j.ijcard.2012.09.123
11. Dengfeng Gao, Ning Ning, Xiaolin Niu. Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart 2011; 97: 278–86.
12. Lei Zhang, Yizhou Lu, Hong Jiang. Additional Use of Trimetazidine in Patients With Chronic Heart Failure A Meta-Analysis. J Am Col Cardiol 2012; 59 (10).
13. Xiaohan Xu, Weijun Zhang, Yujie Zhou. Effect of Trimetazidine on Recurrent Angina Pectoris and Left Ventricular Structure in Elderly Multivessel Coronary Heart Disease Patients with Diabetes Mellitus After Drug-Eluting Stent Implantation: A Single-Centre, Prospective, Randomized, Double-Blind Study at 2-Year Follow-Up. Springer International Publishing Switzerland 2014. Clin Drug Invest. DOI 10.1007/s40261-014-0170-9
Авторы
Е.В.Акатова
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1 akev@list.ru
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E.V.Akatova
A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1 akev@list.ru