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Возможности современной терапии первичных системных васкулитов
Зыкова А.С., Щеголева Е.М., Буланов Н.М. и др. Возможности современной терапии первичных системных васкулитов. Consilium Medicum. 2018; 20 (12): 86–93. DOI: 10.26442/20751753.2018.12.000047
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Zykova A.S., Schegoleva E.M., Bulanov N.M. et al. Current therapy of primary systemic vasculitis. Consilium Medicum. 2018; 20 (12): 86–93. DOI: 10.26442/20751753.2018.12.000047
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Аннотация
Системные васкулиты – редкая группа заболеваний, характеризующаяся неблагоприятным прогнозом без корректно подобранной терапии. Иммуносупрессивная терапия (ИСТ), представляющая собой комбинации глюкокортикостероидов и цитостатиков, а теперь и генно-инженерных биологических препаратов, повышает выживаемость при данных заболеваниях, однако может быть ассоциирована с развитием грозных осложнений. В обзоре обсуждаются основные схемы ИСТ, применяемые в лечении системных васкулитов, поражающих мелкие и крупные сосуды, текущие сложности и перспективы такого лечения.
Ключевые слова: гигантоклеточный артериит, артериит Такаясу, АНЦА-ассоциированные васкулиты, HCV-ассоциированный криоглобулинемический васкулит, клинические исследования.
Ключевые слова: гигантоклеточный артериит, артериит Такаясу, АНЦА-ассоциированные васкулиты, HCV-ассоциированный криоглобулинемический васкулит, клинические исследования.
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Systemic vasculitis is a group of rare diseases characterized by unfavorable prognosis without correct therapy. Today survival rate in this patient increased due to usage of modern immunosuppressive therapy (IST) which consists of combinations of glucocorticosteroids, cytostatic agents and biological drugs. Unfortunately, its use can also be associated with development of serious complications. The review discusses the basic IST regimen of vasculitis treatment their complexity and perspectives.
Key words: giant cell arteritis, Takayasu disease, ANCA associated vasculitis, HCV-associated cryoglobulinemic vasculitis, clinical studies.
Key words: giant cell arteritis, Takayasu disease, ANCA associated vasculitis, HCV-associated cryoglobulinemic vasculitis, clinical studies.
Полный текст
Список литературы
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70. Novikov P, Moiseev S. Biologic therapy for eosinophilic granulomatosis with polyangiitis: comment on the article by Jachiet et al. Arthritis Rheumatol 2016. DOI: 10.1002/art.40015
71. Jachiet M, Samson M, Cottin V et al. Anti-IgE Monoclonal Antibody (Omalizumab) in Refractory and Relapsing Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss): Data on Seventeen Patients. Arthritis Rheumatol 2016; 68 (9): 2274–82. DOI: 10.1002/art.39663
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Авторы
А.С.Зыкова*1, Е.М.Щеголева2, Н.М.Буланов2, П.И.Новиков2, С.В.Моисеев1,2
1 ФГБОУ ВО «Московский государственный университет им. М.В.Ломоносова». 119192, Россия, Москва, Ломоносовский пр., д. 31, корп. 5;
2 ФГАОУ ВО «Первый Московский государственный университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
1 ФГБОУ ВО «Московский государственный университет им. М.В.Ломоносова». 119192, Россия, Москва, Ломоносовский пр., д. 31, корп. 5;
________________________________________________
A.S.Zykova*1, E.M.Schegoleva2, N.M.Bulanov2, P.I.Novikov2, S.V.Moiseev1,2
1 M.V.Lomonosov Moscow State University. 119192, Russian Federation, Moscow, Lomonosovskii pr., d. 31, korp. 5;
2 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 21 M.V.Lomonosov Moscow State University. 119192, Russian Federation, Moscow, Lomonosovskii pr., d. 31, korp. 5;
*ansezy@gmail.com
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