Воспалительные заболевания околоносовых пазух – наиболее распространенные патологии ЛОР-органов во всех возрастных группах. Среди больных, находящихся на лечении в оториноларингологических стационарах, от 15 до 36% составляют пациенты, страдающие заболеваниями околоносовых пазух. В амбулаторной практике доля пациентов с синуситами приблизительно такая же. Острый синусит является одним из наиболее распространенных заболеваний, с которыми сталкиваются врачи первичной медико-санитарной помощи.
Inflammatory diseases of the paranasal sinuses is the most common chronic pathology of ENT organs in all age groups. Among patients who were treated in ENT wards, from 15 to 36% are patients with diseases of the paranasal sinuses. In outpatient practice, the proportion of patients with sinusitis is approximately the same. Acute sinusitis is one of the most common diseases faced by primary health care doctors.
Key words: acute sinusitis, antibacterial therapy with cephalosporins.
1. Gonzales R, Steiner JF, Lum A, Barrett PHJr. Decreasing antibiotic use in ambulatory practice: impact of a multidimensional intervention on the treatment of uncomplicated acute bronchitis in adults. JAMA 1999; 281: 1512–9.
2. Sharp HJ, Denman D, Puumala S, Leopold DA. Treatment of acute and chronic rhinosinusitis in the United States, 1999–2002. Arch Otolaryngol Head Neck Surg 2007; 133: 260–5.
3. Fairlie T, Shapiro DJ, Hersh AL, Hicks LA. National trends in visit rates and antibiotic prescribing for adults with acute sinusitis. Arch Intern Med 2012; 172: 1513–4.
4. Smith SS, Kern RC, Chandra RK et al. Variations in antibiotic prescribing of acute rhinosinusitis in United States ambulatory settings. Otolaryngol Head Neck Surg 2013; 148: 852–9.
5. Garbutt JM, Banister C, Spitznagel E, Piccirillo JF. Amoxicillin for acute rhinosinusitis: a randomized controlled trial. JAMA 2012; 307: 685–92.
6. Ahovuo-Saloranta A, Borisenko OV, Kovanen N et al. Antibiotics for acute maxillary sinusitis. Cochrane Database Syst Rev 2008: CD000243.
7. Fokkens WJ, Lund VJ, Mullol J et al. European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50: 1–307.
8. Smith SR, Montgomery LG, Williams JWJr. Treatment of mild to moderate sinusitis. Arch Intern Med 2012; 172: 510–3.
9. Rosenfeld RM, Andes D, Bhattacharyya N et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137: S1–31.
10. Fokkens W, Lund V, Mullol J. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 2007; p. 1–136.
11. Meltzer EO, Hamilos DL. Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines. Mayo Clin Proc 2011; 86: 427–443.
12. Острый синусит. Клинические рекомендации. М., 2016. / Ostryi sinusit. Klinicheskie rekomendatsii. M., 2016. [in Russian]
13. Young Kyung Yoon, Chan-Soon Park, Jae Wook Kim et al. Guidelines for the Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections. Infect Chemother 2017; 49 (4): 326–52.
14. Meltzer EO, Hamilos DL, Hadley JA et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004; 114: 155–212.
15. Anon JB, Jacobs MR, Poole MD et al. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg 2004; 130: 1–45.
16. Rosenfeld RM. Clinical practice guideline on adult sinusitis. Otolaryngol Head Neck Surg 2007; 137: 365–77.
17. Anzai Y, Jarvik JG, Sullivan SD, Hollingworth W. The cost-effectiveness of the management of acute sinusitis. Am J Rhinol 2007; 21: 444–51.
18. Balk EM, Zucker DR, Engels EA et al. Strategies for diagnosing and treating suspected acute bacterial sinusitis: a cost-effectiveness analysis. J Gen Intern Med 2001; 16: 701–11.
19. Amin NM, Breadon G. An open-label, noncomparative study to evaluate the efficacy, safety, and tolerability of azithromycin in the treatment of patients with acute sinusitis. Clin Ther 1995; 17: 701–7.
20. Anon JB, Ferguson B, Twynholm M et al. Pharmacokinetically enhanced amoxicillin/clavulanate (2,000/125 mg) in acute bacterial rhinosinusitis caused by Streptococcus pneumoniae, including penicillin-resistant strains. Ear Nose Throat J 2006; 85: 500, 502, 504.
21. Arrieta JR, Galgano AS, Sakano E et al. Moxifloxacin vs amoxicillin/clavulanate in the treatment of acute sinusitis. Am J Otolaryngol 2007; 28: 78–82.
22. Benninger MS, Payne SC, Ferguson BJ et al. Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg 2006; 134: 3–9.
23. Shintani S Smith, Henderson E Ference et al. The prevalence of bacterial infection in acute rhinosinusitis: A systematic review and meta-analysis. Laryngoscope 2015; 125 (1): 57–69.
24. Slavin RG, Spector SL, Bernstein IL et al. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol 2005; 116: S13–47.
25. American Academy of Allergy A & Immunology. Choosing Wisely: Five Things Physicians and Patients Should Question. 2012.
26. Meltzer EO, Hamilos DL, Hadley JA et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004; 114: 155–212.
27. Chow AW, Benninger MS, Brook I et al. IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults. Clin Infect Dis 2012; 54: e72–e112.
28. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinol Suppl 2012; 50: 1–12.
29. Chow AW, Benninger MS, Brook I et al. Infectious Diseases Society of America IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 2012; 54: e72–e112.
30. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg 2015; 152 (Suppl.): S1–S39.
31. Gwaltney JMJr, Scheld WM, Sande MA, Sydnor A. The microbial etiology and antimicrobial therapy of adults with acute community-acquired sinusitis: a fifteen-year experience at the University of Virginia and review of other selected studies. J Allergy Clin Immunol. 1992; 90: 457–61.
32. Sokol W. Epidemiology of sinusitis in the primary care setting: results from the 1999–2000 respiratory surveillance program. Am J Med 2001; 111 (Suppl. 9A): 19S–24S.
33. Ahovuo-Saloranta A, Rautakorpi UM, Borisenko OV et al. Antibiotics for acute maxillary sinusitis in adults. Cochrane Database Syst Rev 2014: CD000243.
34. Henry DC, Riffer E, Sokol WN et al. Randomized double-blind study comparing 3- and 6-day regimens of azithromycin with a 10-day amoxicillin-clavulanate regimen for treatment of acute bacterial sinusitis. Antimicrob Agents Chemother. 2003; 47: 2770–4.
35. Luterman M, Tellier G, Lasko B, Leroy B. Efficacy and tolerability of telithromycin for 5 or 10 days vs amoxicillin/clavulanic acid for 10 days in acute maxillary sinusitis. Ear Nose Throat J 2003; 82: 576–80, 582–4.
36. Berg O, Carenfelt C. Analysis of symptoms and clinical signs in the maxillary sinus empyema. Acta Otolaryngol 1988; 105: 343–9.
37. Jenkins SG, Farrell DJ, Patel M, Lavin BS. Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000–2003: PROTEKT US years 1–3. J Infect 2005; 51: 355–63.
38. Falagas ME, Karageorgopoulos DE, Grammatikos AP, Matthaiou DK. Effectiveness and safety of short vs. long duration of antibiotic therapy for acute bacterial sinusitis: a meta-analysis of randomized trials. Br J Clin Pharmacol 2009; 67: 161–71.
39. Lemiengre MB, van Driel ML, Merenstein D et al. Antibiotics for clinically diagnosed acute rhinosinusitis in adults. Cochrane Database Syst Rev 2012; 10: CD006089.
40. Jacobs MR. Antimicrobial-resistant Streptococcus pneumoniae: trends and management. Expert Rev Anti Infect Ther 2008; 6: 619–35.
41. Lynch JP 3rd, Zhanel GG. Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines. Curr Opin Pulm Med 2010; 16: 217–25.
42. Karageorgopoulos DE, Giannopoulou KP, Grammatikos AP et al. Fluoroquinolones compared with beta-lactam antibiotics for the treatment of acute bacterial sinusitis: a meta-analysis of randomized controlled trials. CMAJ 2008; 178: 845–54.
43. Harrison CJ, Woods C, Stout G et al. Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. J Antimicrob Chemother 2009; 63: 511–9.
44. Desrosiers M, Evans GA, Keith PK et al. Canadian clinical practice guidelines for acute and chronic rhinosinusitis. J Otolaryngol Head Neck Surg 2011; 40 (Suppl. 2): S99–S193.
45. Fenoll A, Giménez MJ, Robledo O et al. In vitro activity of oral cephalosporins against pediatric isolates of Streptococcus pneumoniae non-susceptible to penicillin, amoxicillin or erythromycin. J Chemother 2008; 20: 175–9.
46. Fenoll A, Giménez MJ, Robledo O et al. Influence of penicillin/amoxicillin non-susceptibility on the activity of third-generation cephalosporins against Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis 2008; 27: 75–80.
47. Sader HS, Jacobs MR, Fritsche TR. Review of the spectrum and potency of orally administered cephalosporins and amoxicillin/clavulanate. Diagn Microbiol Infect Dis 2007; 57 (Suppl): 5S–12S.
48. Jansen WT, Verel A, Beitsma M et al. Surveillance study of the susceptibility of Haemophilus influenzae to various antibacterial agents in Europe and Canada. Curr Med Res Opin 2008; 24: 2853–61.
49. Fenoll A, Aguilar L, Robledo O et al. Influence of the beta-lactam resistance phenotype on the cefuroxime versus cefditoren susceptibility of Streptococcus pneumoniae and Haemophilus influenzae recovered from children with acute otitis media. J Antimicrob Chemother 2007; 60: 323–7.
50. Poachanukoon O, Kitcharoensakkul M. Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: a randomized, investigator-blinded, controlled trial. Clin Ther 2008; 30: 1870–9.
51. Ebell MH, Smith MA, Barry HC et al. Does this patient have strep throat? JAMA 2000; 284: 2912–8.
52. Gidengil CA, Kruskal BA, Lee GM. Initial antibiotic choice in the treatment of group A streptococcal pharyngitis and return visit rates. J Pediatric Infect Dis Soc 2013; 2: 361–7.
________________________________________________
1. Gonzales R, Steiner JF, Lum A, Barrett PHJr. Decreasing antibiotic use in ambulatory practice: impact of a multidimensional intervention on the treatment of uncomplicated acute bronchitis in adults. JAMA 1999; 281: 1512–9.
2. Sharp HJ, Denman D, Puumala S, Leopold DA. Treatment of acute and chronic rhinosinusitis in the United States, 1999–2002. Arch Otolaryngol Head Neck Surg 2007; 133: 260–5.
3. Fairlie T, Shapiro DJ, Hersh AL, Hicks LA. National trends in visit rates and antibiotic prescribing for adults with acute sinusitis. Arch Intern Med 2012; 172: 1513–4.
4. Smith SS, Kern RC, Chandra RK et al. Variations in antibiotic prescribing of acute rhinosinusitis in United States ambulatory settings. Otolaryngol Head Neck Surg 2013; 148: 852–9.
5. Garbutt JM, Banister C, Spitznagel E, Piccirillo JF. Amoxicillin for acute rhinosinusitis: a randomized controlled trial. JAMA 2012; 307: 685–92.
6. Ahovuo-Saloranta A, Borisenko OV, Kovanen N et al. Antibiotics for acute maxillary sinusitis. Cochrane Database Syst Rev 2008: CD000243.
7. Fokkens WJ, Lund VJ, Mullol J et al. European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50: 1–307.
8. Smith SR, Montgomery LG, Williams JWJr. Treatment of mild to moderate sinusitis. Arch Intern Med 2012; 172: 510–3.
9. Rosenfeld RM, Andes D, Bhattacharyya N et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137: S1–31.
10. Fokkens W, Lund V, Mullol J. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 2007; p. 1–136.
11. Meltzer EO, Hamilos DL. Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines. Mayo Clin Proc 2011; 86: 427–443.
12. Ostryi sinusit. Klinicheskie rekomendatsii. M., 2016. [in Russian]
13. Young Kyung Yoon, Chan-Soon Park, Jae Wook Kim et al. Guidelines for the Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections. Infect Chemother 2017; 49 (4): 326–52.
14. Meltzer EO, Hamilos DL, Hadley JA et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004; 114: 155–212.
15. Anon JB, Jacobs MR, Poole MD et al. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg 2004; 130: 1–45.
16. Rosenfeld RM. Clinical practice guideline on adult sinusitis. Otolaryngol Head Neck Surg 2007; 137: 365–77.
17. Anzai Y, Jarvik JG, Sullivan SD, Hollingworth W. The cost-effectiveness of the management of acute sinusitis. Am J Rhinol 2007; 21: 444–51.
18. Balk EM, Zucker DR, Engels EA et al. Strategies for diagnosing and treating suspected acute bacterial sinusitis: a cost-effectiveness analysis. J Gen Intern Med 2001; 16: 701–11.
19. Amin NM, Breadon G. An open-label, noncomparative study to evaluate the efficacy, safety, and tolerability of azithromycin in the treatment of patients with acute sinusitis. Clin Ther 1995; 17: 701–7.
20. Anon JB, Ferguson B, Twynholm M et al. Pharmacokinetically enhanced amoxicillin/clavulanate (2,000/125 mg) in acute bacterial rhinosinusitis caused by Streptococcus pneumoniae, including penicillin-resistant strains. Ear Nose Throat J 2006; 85: 500, 502, 504.
21. Arrieta JR, Galgano AS, Sakano E et al. Moxifloxacin vs amoxicillin/clavulanate in the treatment of acute sinusitis. Am J Otolaryngol 2007; 28: 78–82.
22. Benninger MS, Payne SC, Ferguson BJ et al. Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg 2006; 134: 3–9.
23. Shintani S Smith, Henderson E Ference et al. The prevalence of bacterial infection in acute rhinosinusitis: A systematic review and meta-analysis. Laryngoscope 2015; 125 (1): 57–69.
24. Slavin RG, Spector SL, Bernstein IL et al. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol 2005; 116: S13–47.
25. American Academy of Allergy A & Immunology. Choosing Wisely: Five Things Physicians and Patients Should Question. 2012.
26. Meltzer EO, Hamilos DL, Hadley JA et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004; 114: 155–212.
27. Chow AW, Benninger MS, Brook I et al. IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults. Clin Infect Dis 2012; 54: e72–e112.
28. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinol Suppl 2012; 50: 1–12.
29. Chow AW, Benninger MS, Brook I et al. Infectious Diseases Society of America IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 2012; 54: e72–e112.
30. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg 2015; 152 (Suppl.): S1–S39.
31. Gwaltney JMJr, Scheld WM, Sande MA, Sydnor A. The microbial etiology and antimicrobial therapy of adults with acute community-acquired sinusitis: a fifteen-year experience at the University of Virginia and review of other selected studies. J Allergy Clin Immunol. 1992; 90: 457–61.
32. Sokol W. Epidemiology of sinusitis in the primary care setting: results from the 1999–2000 respiratory surveillance program. Am J Med 2001; 111 (Suppl. 9A): 19S–24S.
33. Ahovuo-Saloranta A, Rautakorpi UM, Borisenko OV et al. Antibiotics for acute maxillary sinusitis in adults. Cochrane Database Syst Rev 2014: CD000243.
34. Henry DC, Riffer E, Sokol WN et al. Randomized double-blind study comparing 3- and 6-day regimens of azithromycin with a 10-day amoxicillin-clavulanate regimen for treatment of acute bacterial sinusitis. Antimicrob Agents Chemother. 2003; 47: 2770–4.
35. Luterman M, Tellier G, Lasko B, Leroy B. Efficacy and tolerability of telithromycin for 5 or 10 days vs amoxicillin/clavulanic acid for 10 days in acute maxillary sinusitis. Ear Nose Throat J 2003; 82: 576–80, 582–4.
36. Berg O, Carenfelt C. Analysis of symptoms and clinical signs in the maxillary sinus empyema. Acta Otolaryngol 1988; 105: 343–9.
37. Jenkins SG, Farrell DJ, Patel M, Lavin BS. Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000–2003: PROTEKT US years 1–3. J Infect 2005; 51: 355–63.
38. Falagas ME, Karageorgopoulos DE, Grammatikos AP, Matthaiou DK. Effectiveness and safety of short vs. long duration of antibiotic therapy for acute bacterial sinusitis: a meta-analysis of randomized trials. Br J Clin Pharmacol 2009; 67: 161–71.
39. Lemiengre MB, van Driel ML, Merenstein D et al. Antibiotics for clinically diagnosed acute rhinosinusitis in adults. Cochrane Database Syst Rev 2012; 10: CD006089.
40. Jacobs MR. Antimicrobial-resistant Streptococcus pneumoniae: trends and management. Expert Rev Anti Infect Ther 2008; 6: 619–35.
41. Lynch JP 3rd, Zhanel GG. Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines. Curr Opin Pulm Med 2010; 16: 217–25.
42. Karageorgopoulos DE, Giannopoulou KP, Grammatikos AP et al. Fluoroquinolones compared with beta-lactam antibiotics for the treatment of acute bacterial sinusitis: a meta-analysis of randomized controlled trials. CMAJ 2008; 178: 845–54.
43. Harrison CJ, Woods C, Stout G et al. Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. J Antimicrob Chemother 2009; 63: 511–9.
44. Desrosiers M, Evans GA, Keith PK et al. Canadian clinical practice guidelines for acute and chronic rhinosinusitis. J Otolaryngol Head Neck Surg 2011; 40 (Suppl. 2): S99–S193.
45. Fenoll A, Giménez MJ, Robledo O et al. In vitro activity of oral cephalosporins against pediatric isolates of Streptococcus pneumoniae non-susceptible to penicillin, amoxicillin or erythromycin. J Chemother 2008; 20: 175–9.
46. Fenoll A, Giménez MJ, Robledo O et al. Influence of penicillin/amoxicillin non-susceptibility on the activity of third-generation cephalosporins against Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis 2008; 27: 75–80.
47. Sader HS, Jacobs MR, Fritsche TR. Review of the spectrum and potency of orally administered cephalosporins and amoxicillin/clavulanate. Diagn Microbiol Infect Dis 2007; 57 (Suppl): 5S–12S.
48. Jansen WT, Verel A, Beitsma M et al. Surveillance study of the susceptibility of Haemophilus influenzae to various antibacterial agents in Europe and Canada. Curr Med Res Opin 2008; 24: 2853–61.
49. Fenoll A, Aguilar L, Robledo O et al. Influence of the beta-lactam resistance phenotype on the cefuroxime versus cefditoren susceptibility of Streptococcus pneumoniae and Haemophilus influenzae recovered from children with acute otitis media. J Antimicrob Chemother 2007; 60: 323–7.
50. Poachanukoon O, Kitcharoensakkul M. Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: a randomized, investigator-blinded, controlled trial. Clin Ther 2008; 30: 1870–9.
51. Ebell MH, Smith MA, Barry HC et al. Does this patient have strep throat? JAMA 2000; 284: 2912–8.
52. Gidengil CA, Kruskal BA, Lee GM. Initial antibiotic choice in the treatment of group A streptococcal pharyngitis and return visit rates. J Pediatric Infect Dis Soc 2013; 2: 361–7.
Авторы
А.Б.Туровский*, И.Г.Колбанова, Ю.С.Кудрявцева
ГБУЗ «Научно-исследовательский клинический институт оториноларингологии им. Л.И.Свержевского» Департамента здравоохранения г. Москвы. 117152, Россия, Москва, Загородное ш., д. 18а, стр. 2
*an_tur@mail.ru
________________________________________________
A.B.Turovskiy*, I.G.Kolbanova, Yu.S.Kudriavtseva L.I.Swierzewsky Research and Clinical Institute of Otorhinolaryngology of the Department of Health of Moscow. 117152, Russian Federation, Moscow, Zagorodnoe sh., d. 18a, str. 2 *an_tur@mail.ru