Полиморфизм генов SOCS5 и EGFR при бронхиальной астме

Аверьянов А.Б., Черкашина И.И., Никулина С.Ю., Шестовицкий В.А. Полиморфизм генов SOCS5 и EGFR при бронхиальной астме. Consilium Medicum. 2018; 20 (3): 45–47. DOI: 10.26442/2075-1753_20.3.45-47

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Averyanov A.B., Chercashina I.I., Nikulina S.Yu., Shestovitskiy V.A. Polymorphism of genes SOCS5 and EGFR with bronchial asthma. Consilium Medicum. 2018; 20 (3): 45–47. DOI: 10.26442/2075-1753_20.3.45-47

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Аннотация

В представленной статье отражен научный обзор литературных данных за последние 20 лет, касающихся гена – супрессора цитокиновых сигналов (SOCS5) и гена рецептора эпидермального фактора роста (EGFR), на основе материалов баз данных OMIM, PubMed. Были проанализированы механизмы действия генов SOCS5 и EGFR, их структура и функционирование белков, кодируемых этими генами. Также отражены данные опубликованных исследований, которые свидетельствуют о роли генов SOCS5 и EGFR в развитии патологии органов дыхания и других систем органов. На примере ряда исследований продемонстрирована ассоциация данных генов с влиянием на развитие бронхиальной астмы.

Ключевые слова: ген, SOCS5, EGFR, однонуклеотидный полиморфизм, мультифакториальное заболевание, бронхиальная астма.

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The article presents the scientific literature review of the previous 20 years about gene – supressor of cytokine signaling SOCS5 and gene of epidermal growth factor receptor EGFR adapted from data pool of OMIM, PubMed. Were analised the mechanisms of the gene SOCS5 and gene EGFR, structure and functioning of proteins encoded by these genes. The results of published studies have confirmed the role of SOCS5 gene and EGFR in the pathology of the lungs and other system of organs. For example, some studies have shown аssociation of these genes with the development of asthma.

Key words: gene, SOCS5, EGFR, SNP, multifactorial disease, bronchial asthma.

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Список литературы

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31. Arau JA, Ribeiro R, Azevedo I et al. Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer – a review of the literature. Oncologist 2007; 12: 201–10. DOI: 10.1634/theoncologist.12-2-201
32. Yang PW, Hsieh MS, Huang YC et al. Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma. PLoS One 2014; 9 (6): e100326. DOI: 10.1371/journal.pone.0100326
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35. Li C, Wei R, Jones-Hall YL et al. Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association study. Sci Reports 2014; 4: 4893. DOI: 10.1038/srep04893
36. Huang CM, Chen HH, Chen DC et al. Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein. PLoS One 2017; 12 (7): e0180604. DOI: 10.1371/journal.pone.0180604
37. Yoshikawa T, Kanazawa H. Integrated effect of EGFR and PAR-1 signaling crosstalk on airway hyperresponsiveness. Int J Mol Med 2012; 30 (1): 41–8. DOI: 10.3892/ijmm.2012.981
38. Le Cras TD, Acciani TH, Mushaben EM et al. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiolog 2011; 300 (3): 414–21. DOI: 10.1152/ajplung.00346.2010
39. Hilton DJ. Negative regulators of cytokine signal transduction. Cell Mol Life Sci 1999; 55: 1568–77. DOI: 10.1007/s000180050396
40. Naka T, Fujimoto M, Kishimoto T. Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. Trends Biochem Sci 1999; 24: 394–8. DOI: 10.1016/s0968-0004(99)01454-1
41. Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Аnnu Rev Immunol 2000; 18: 143–64. DOI: 10.1146/annurev.immunol.18.1.143
42. Feng ZP, Chandrashekaran IR, Low A et al. The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5. Proteins 2012; 80 (3): 946–57. DOI: 10.1002/prot.23252
43. Saltykova IV, Ogorodova LM, Bragina EY et al. Opisthorchis felineus liver fluke invasion is an environmental factor modifying genetic risk of atopic bronchial asthma. Acta Tropica 2014; 139: 53–6. DOI: 10.1016/j.actatropica.2014.07.004
44. Linossi EM, Chandrashekaran IR, Kolesnik TB et al. Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. PLoS One 2013; 8 (8): e70536. DOI: 10.1371/journal.pone.0070536
45. Zhuang G, Wu X, Jiang Z et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. The EMBO J 2012; 31 (17): 3513–23. DOI: 10.1038/emboj.2012.183
46. Yoon S, Yi YS, Kim SS et al. SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues. Tumour Biol 2012; 33 (1): 215–21. DOI: 10.1007/s13277-011-0264-4
47. Ozaki A, Seki Y, Fukushima A, Kubo M. The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. J Immunol 2005; 175 (8): 5489–97. DOI: 10.4049/jimmunol.175.8.5489
48. Toghi M, Taheri M, Arsang-Jang S et al. SOCS gene family expression profile in the blood of multiple sclerosis patients. J Neurol Sci 2017; 375: 481–5. DOI: 10.1016/j.jns.2017.02.015

49. Kario E, Marmor MD, Adamsky K et al. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. J Biol Chemistry 2005; 280 (8): 7038–48. DOI: 10.1074/jbc.M408575200

________________________________________________

1. March ME, Sleiman PM, Hakonarson H. The genetics of asthma and allergic disorders. Discovery Medicine 2011; 56 (11): 35–45.
2. Saltykova I.V., Freidin M.B., Bragina E.Iu. i dr. Assotsiatsiia polimorfizma rs6737848 gena SOCS5 s bronkhial'noi astmoi. Vestn. Ros. akademii meditsinskikh nauk. 2013; 7: 53–6. DOI: 10.15690/vramn.v68i7.713 [in Russian]
3. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2016 [Accessed 2016]. Available on [www.ginasthma.org].
4. Chuchalin A.G. Bronkhial'naia astma. M.: Meditsina, 2003. [in Russian]
5. Chuchalin A.G., Il'kovich M.M. Spravochnik po pul'monologii. M.: GEOTAR-Media, 2014. [in Russian]
6. Freidin M.B., Ogorodova L.M., Tsoi A.N., Berdnikova N.G. Genetikabronkhial'noi astmy. Genetika bronkholegochnykh zabolevanii. M.: Atmosfera, 2010; s. 78–104. [in Russian].
7. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nature Reviews Immunology 2008; 8 (3): 169–82. DOI: 10.1038/nri2257
8. Balabolkin I.I., Bulgakova V.A. Geneticheskie aspekty formirovaniia effektivnosti i bezopasnosti farmakoterapii atopicheskoi bronkhial'noi astmy u detei. Farmateka. 2016; 14: 14–9. [in Russian]
9. Razvodovskaia A.V., Cherkashina I.I., Nikulina S.Iu. i dr. Izuchenie assotsiatsii odnonukleotidnogo polimorfizma rsl800470 gena transformiruiushchego faktora rosta beta 1 (TGF-b1) s riskom razvitiia bronkhial'noi astmy. Sib. med. obozrenie. 2014; 2: 17–22. DOI: 10.20333/25000136-2014-2-17-22. [in Russian]
10. Cherkashina I.I., Nikulina S.Iu., Maksimov V.N. i dr. Osobennosti polimorfizma gena khemokinovogo retseptora CCR2 u bol'nykh bronkhial'noi astmoi i khronicheskoi obstruktivnoi bolezn'iu legkikh. Sib. med. obozrenie. 2013; 2: 19–23. [in Russian]
11. Li Y, Wu B, Xiong H et al. Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population. Respir Med 2007; 101 (9): 1977–81. DOI: 10.1016/j.rmed.2007.04.006
12. Hsieh YY, Wan L, Chang CC et al. STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. Int J Biol Sci 2009; 5 (1): 74–81. DOI: 10.7150/ijbs.5.74
13. Ege MJ, Mayer M, Schwaiger K et al. Environmental bacteria and childhood asthma. Allergy 2012; 67 (12): 1565–71. DOI: 10.1111/all.12028
14. Hilty M, Burke C, Pedro H et al. Disordered microbial communities in asthmatic airways. PLoS One 2010; 5 (1): е8578. DOI: 10.1371/journal.pone.0008578
15. Seki Y, Hayashi K, Matsumoto A et al. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proceedings of the National Academy of Sciences of the USA. 2002; 99 (20): 13003–8. DOI: 10.1073/pnas.202477099
16. O’Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998; 8 (3): 275–83. DOI: 10.1016/s1074-7613(00)80533-6
17. Khaitov R.M., Pinegin B.V., Iarilin A.A. Rukovodstvo po klinicheskoi immunologii. Diagnostika zabolevanii immunnoi sistemy: Rukovodstvo dlia vrachei. M.: GEOTAR-Media, 2009. [in Russian]
18. Athanassakis I, Vassiliadis S. T regulatory cells: are we re-discovering T suppressors. Immunology Letters 2002; 84: 179–83. DOI: 10.1016/s0165-2478(02)00182-7
19. Murphy KM, Ouyang W, Farrar JD et al. Signaling and transcription in T helper development. Аnnu Rev Immunol 2000; 18: 451–94. DOI: 10.1146/annurev.immunol.18.1.451
20. Freidlin I.S. Reguliatornye T-kletki: proiskhozhdenie i funktsii. Med. immunologiia. 2005; 7 (4): 347–54. [in Russian]
21. Ouyang W, Lohning M, Gao Z et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000; 12: 27–37. DOI: 10.1016/s1074-7613(00)80156-9
22. Lee H-J, Takemoto N, Kurata H et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med 2000; 192: 105–15. DOI: 10.1084/jem.192.1.105
23. Kubo M, Ransom J, Webb D et al. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. The EMBO J 1997; 16: 4007–20. DOI: 10.1093/emboj/16.13.4007
24. Huang H, Paul WE. Impaired interleukin 4 signaling in T helper type 1 cells. J of Exp Med 1998; 187: 1305–313. DOI: 10.1084/jem.187.8.1305
25. Hsu SC, Miller SA, Wang Y, Hung MC. Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res 2009; 1: 249–58. DOI: 10.1158/0008-5472.can-10-2384
26. Bai J, Guo XG, Bai XP. Epidermal growth factor receptor-related DNA repair and radiation-resistance regulatory mechanisms: a mini-review. Asia Pac J Cancer Prevent 2012; 13: 4879–81. DOI: 10.7314/apjcp.2012.13.10.4879
27. Rodemann HP, Dittmann K, Toulany M. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int J Radiat Biol 2007; 83: 781–91. DOI: 10.1080/09553000701769970
28. Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007; 7: 169–81. DOI: 10.1038/nrc2088
29. Albitar L, Pickett G, Morgan M et al. EGFR isoforms and gene regulation in human endometrial cancer cells. Molecular Cancer 2010; 9: 166. DOI: 10.1186/1476-4598-9-166
30. Guillaudeau A, Durand K, Rabinovitch-Chable H et al. Adult diffuse gliomas produce mRNA transcripts encoding EGFR isoforms lacking a tyrosine kinase domain. Int J Oncol 2012; 40: 1142–52. DOI: 10.3892/ijo.2011.1287
31. Arau JA, Ribeiro R, Azevedo I et al. Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer – a review of the literature. Oncologist 2007; 12: 201–10. DOI: 10.1634/theoncologist.12-2-201
32. Yang PW, Hsieh MS, Huang YC et al. Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma. PLoS One 2014; 9 (6): e100326. DOI: 10.1371/journal.pone.0100326
33. Zhang J, Zhan Z, Wu J et al. Association among polymorphisms in EGFR gene exons, lifestyle and risk of gastric cancer with gender differences in Chinese Han subjects. PLoS One 2013; 8 (3): e59254. DOI: 10.1371/journal.pone.0059254
34. Gerger A, El-Khoueiry A, Zhang W et al. Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res 2011; 17 (17): 5783–92. DOI: 10.1158/1078-0432.CCR-11-1115
35. Li C, Wei R, Jones-Hall YL et al. Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association study. Sci Reports 2014; 4: 4893. DOI: 10.1038/srep04893
36. Huang CM, Chen HH, Chen DC et al. Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein. PLoS One 2017; 12 (7): e0180604. DOI: 10.1371/journal.pone.0180604
37. Yoshikawa T, Kanazawa H. Integrated effect of EGFR and PAR-1 signaling crosstalk on airway hyperresponsiveness. Int J Mol Med 2012; 30 (1): 41–8. DOI: 10.3892/ijmm.2012.981
38. Le Cras TD, Acciani TH, Mushaben EM et al. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiolog 2011; 300 (3): 414–21. DOI: 10.1152/ajplung.00346.2010
39. Hilton DJ. Negative regulators of cytokine signal transduction. Cell Mol Life Sci 1999; 55: 1568–77. DOI: 10.1007/s000180050396
40. Naka T, Fujimoto M, Kishimoto T. Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. Trends Biochem Sci 1999; 24: 394–8. DOI: 10.1016/s0968-0004(99)01454-1
41. Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Аnnu Rev Immunol 2000; 18: 143–64. DOI: 10.1146/annurev.immunol.18.1.143
42. Feng ZP, Chandrashekaran IR, Low A et al. The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5. Proteins 2012; 80 (3): 946–57. DOI: 10.1002/prot.23252
43. Saltykova IV, Ogorodova LM, Bragina EY et al. Opisthorchis felineus liver fluke invasion is an environmental factor modifying genetic risk of atopic bronchial asthma. Acta Tropica 2014; 139: 53–6. DOI: 10.1016/j.actatropica.2014.07.004
44. Linossi EM, Chandrashekaran IR, Kolesnik TB et al. Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. PLoS One 2013; 8 (8): e70536. DOI: 10.1371/journal.pone.0070536
45. Zhuang G, Wu X, Jiang Z et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. The EMBO J 2012; 31 (17): 3513–23. DOI: 10.1038/emboj.2012.183
46. Yoon S, Yi YS, Kim SS et al. SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues. Tumour Biol 2012; 33 (1): 215–21. DOI: 10.1007/s13277-011-0264-4
47. Ozaki A, Seki Y, Fukushima A, Kubo M. The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. J Immunol 2005; 175 (8): 5489–97. DOI: 10.4049/jimmunol.175.8.5489
48. Toghi M, Taheri M, Arsang-Jang S et al. SOCS gene family expression profile in the blood of multiple sclerosis patients. J Neurol Sci 2017; 375: 481–5. DOI: 10.1016/j.jns.2017.02.015
49. Kario E, Marmor MD, Adamsky K et al. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. J Biol Chemistry 2005; 280 (8): 7038–48. DOI: 10.1074/jbc.M408575200

Авторы

А.Б.Аверьянов*, И.И.Черкашина, С.Ю.Никулина, В.А.Шестовицкий

ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого» Минздрава России. 660022, Россия, Красноярск, ул. Партизана Железняка, д. 1
*Averyanov_a007@mail.ru

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A.B.Averyanov*, I.I.Chercashina, S.Yu.Nikulina, V.A.Shestovitskiy

Prof. V.F.Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation. 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1
*Averyanov_a007@mail.ru

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