Дотация витамина D больным сахарным диабетом: коммерческий подход или рекомендации на основе доказательной медицины
Дотация витамина D больным сахарным диабетом: коммерческий подход или рекомендации на основе доказательной медицины
Каронова Т.Л. Дотация витамина D больным сахарным диабетом: коммерческий подход или рекомендации на основе доказательной медицины. Consilium Medicum. 2018; 20 (4): 33–35. DOI: 10.26442/2075-1753_2018.4.33-35
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Karonova T.L. Vitamin D supplementation in diabetes mellitus patients: commercialism or evidence-based guidance. Consilium Medicum. 2018; 20 (4): 33–35. DOI: 10.26442/2075-1753_2018.4.33-35
Дотация витамина D больным сахарным диабетом: коммерческий подход или рекомендации на основе доказательной медицины
Каронова Т.Л. Дотация витамина D больным сахарным диабетом: коммерческий подход или рекомендации на основе доказательной медицины. Consilium Medicum. 2018; 20 (4): 33–35. DOI: 10.26442/2075-1753_2018.4.33-35
________________________________________________
Karonova T.L. Vitamin D supplementation in diabetes mellitus patients: commercialism or evidence-based guidance. Consilium Medicum. 2018; 20 (4): 33–35. DOI: 10.26442/2075-1753_2018.4.33-35
Настоящая статья посвящена современным представлениям о роли дефицита витамина D в формировании нарушений метаболизма глюкозы и развитии сахарного диабета. Обсуждены эффекты терапии препаратами витамина D на параметры метаболизма глюкозы и их место в комплексном лечении больных сахарным диабетом. Данные, представленные в работе, будут интересны не только эндокринологам, но и врачам смежных специальностей.
The article focuses on contemporary view on vitamin D deficiency role in impaired glucose metabolism and diabetes mellitus development. Effects of vitamin D therapy on glucose metabolism parameters and their place in complex treatment of diabetes mellitus patients are discussed. Presented data would be of interest not only for endocrinologists but also for other health specialists.
Key words: vitamin D deficiency, 25(ОН)D, diabetes mellitus.
1. Lai YH, Fang TC. The pleiotropic effect of vitamin D. ISRN nephrology 2013; Article ID 898125. DOI: 10.5402/2013/898125
2. Christakos S, Dhawan P, Verstuyf A et al. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 2016; 96: 365–408. DOI: 10.1152/physrev.00014.2015
3. Rejnmark L, Bislev LS, Cashman KD et al. Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS ONE 2017; 12 (7): e0180512. DOI: org/10.1371/journal.pone.0180512
4. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol 2014; 144 PA: 138–45. DOI: 10.1016/j.jsbmb.2013.11.003
5. Edwards MH, Cole ZA, Harvey NC, Cooper C. The global epidemiology of vitamin D status. J Aging Res Clin Pract 2014. http://dx.doi.org/10.14283/jarcp.2014.26
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10. Johnson JA, Grande JP, Roche PC et al. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbidin D28k in human and rat pancreas. Am J Physiol 1994; 267: 356–60.
11. Lee S, Clark SA, Gill RK et al. 1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. Endocrinology 1994; 134 (4): 1602–10. DOI: 10.1210/endo.134.4.8137721
12. Rabinovitch A, Suarez-Pinzon WL, Sooy K et al. Expression of calbindin-D28k in a pancreatic Isletb-Cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology 2001; 142 (8): 3649–55. DOI: 10.1210 / endo.142.8.8334
13. Sung CC, Liao MT, Lu KC, Wu CC. Role of Vitamin D in Insulin Resistance. J Biomed Biotech 2012; ID634195. DOI: 10.1155/2012/634195
14. Song Y, Wang L, Pittas AG et al. Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies. Diabetes Care 2013; 36 (5): 14221428. DOI: 10.2337/dc12-0962
15. Sung CC, Liao MT, Lu KC, Wu CC. Role of Vitamin D in Insulin Resistance. J Biomed Biotech 2012; ID634195. DOI: 10.1155/2012/634195
16. Bachali S, Dasu K, Ramalingam K, Naidu JN. Vitamin D deficiency and insulin resistance in normal and type 2 diabetes subjects. Indian J Clin Bioch 2013; 28 (1): 74–8. DOI: 10.1007/s12291-012-0239-2
17. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocrine J 2000; 47 (4): 383–91.
18. Begum N, Leitner W, Reusch JE et al. GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca (2+)-induced inhibition of insulin-stimulated glucose transport. J Biol Chem 1993; 268 (5): 3352–6.
19. Каронова Т.Л., Шмонина И.А., Андреева А.Т. и др. Дефицит витамина D: причина или следствие ожирения? Consilium Medicum. 2016; 18 (4): 49–52. / Karonova T.L., Shmonina I.A., Andreeva A.T. et al. Vitamin D: the cause or the result of obesity? Consilium Medicum. 2016; 18 (4): 49–52. [in Russian]
20. Ishii H, Suzuki H, Baba T et al. Seasonal variation of glycemic control in type 2 diabetic patients. Diabetes Care 2001; 24 (8): 1503.
21. Liang WW. Seasonal changes in preprandial glucose, A1C, and blood pressure in diabetic patients. Diabetes Care 2007; 30 (10): 2501–2.
22. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey. Diabetes Care (2004); 27 (12): 2813–8.
23. Hyppönen E. 25-hydroxyvitamin D, IGF-I, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British cohort. Diabetes 2008; 57: 298–305.
24. Lu L, Yu Z, Pan A et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese. Diabetes Care 2009; 32 (7): 1278–83.
25. Pittas AG, Chung M, Tricalinos T et al. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010; 152: 307–14.
26. Randhawa FA, Mustafa S, Khan DM, Hamid S. Effect of Vitamin D supplementation on reduction in levels of HbA1 in patients recently diagnosed with type 2 Diabetes Mellitus having asymptomatic Vitamin D deficiency. Pakistan J Med Sci 2017; 33 (4); 881–5. DOI: 10.12669/pjms.334.12288
27. Mirhosseini N, Vatanparast H, Mazidi M, Kimball SM. The effect of improved serum 25-Hydroxyvitamin D status on glycemic control in diabetic patients: A Meta-Analysis. J Clin Endocrinol Metab 2017; 102 (9): 3097–10. DOI: 10.1210/jc.2017-01024
28. Hyppönen E. Intake of vitamin D and risk of type 1 diabetes: a birth–cohort study. Lancet 2001; 358: 1500–3.
29. Borissova AM, Tankova T, Kirillov G et al. The effect of vitamin D3 on insulin secretion and peripheral sensitivity in type 2 diabetic patients Int. J Clin Pract 2003; 57 (4): 258–61.
30. Chiu KC, Chu A, Go VLW et al. Hypovitaminosis D is associated with insulin resistance and b cell dysfunction. Am J Clin Nutr 2004; 79 (5): 820–5.
31. Avenell AA, Cook JA, MacLennan GS et al. Vitamin D supplementation and type 2 diabetes: a substudy of a randomized placebo-controlled trial in older people (RECORD trial, ISRCTN 5167438). Age Agening 2009; 38: 606–9.
32. Pittas AG. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006; 29 (3): 650–6.
________________________________________________
1. Lai YH, Fang TC. The pleiotropic effect of vitamin D. ISRN nephrology 2013; Article ID 898125. DOI: 10.5402/2013/898125
2. Christakos S, Dhawan P, Verstuyf A et al. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 2016; 96: 365–408. DOI: 10.1152/physrev.00014.2015
3. Rejnmark L, Bislev LS, Cashman KD et al. Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS ONE 2017; 12 (7): e0180512. DOI: org/10.1371/journal.pone.0180512
4. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol 2014; 144 PA: 138–45. DOI: 10.1016/j.jsbmb.2013.11.003
5. Edwards MH, Cole ZA, Harvey NC, Cooper C. The global epidemiology of vitamin D status. J Aging Res Clin Pract 2014. http://dx.doi.org/10.14283/jarcp.2014.26
6. Pigarova E.A., Rozhinskaya L.Ya., Belaya Zh.E. et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemu endokrinologii. 2016; 62 (4): 60–84. DOI: 10.14341/probl201662460-84 [in Russian]
7. Karonova T, Andreeva A, Nikitina I et al. Prevalence of Vitamin D deficiency in the North-West region of Russia: A cross-sectional study. J Steroid Biochem Mol Biol 2016; 164: 230–4. DOI: 10.1016/j.jsbmb.2016.03.026
8. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96 (7): 1911–30. DOI: 10.1210/jc.2011-0385
9. Belaia Zh.E., Belova K.Yu., Bordakova E.V. i dr. Profilaktika, diagnostika i lechenie defitsita vitamina D i kal'tsiia sredi vzroslogo naseleniia i u patsientov s osteoporozom. Rekomendatsii Rossiiskoi assotsiatsii po osteoporozu. M., 2016. [in Russian]
10. Johnson JA, Grande JP, Roche PC et al. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbidin D28k in human and rat pancreas. Am J Physiol 1994; 267: 356–60.
11. Lee S, Clark SA, Gill RK et al. 1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. Endocrinology 1994; 134 (4): 1602–10. DOI: 10.1210/endo.134.4.8137721
12. Rabinovitch A, Suarez-Pinzon WL, Sooy K et al. Expression of calbindin-D28k in a pancreatic Isletb-Cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology 2001; 142 (8): 3649–55. DOI: 10.1210 / endo.142.8.8334
13. Sung CC, Liao MT, Lu KC, Wu CC. Role of Vitamin D in Insulin Resistance. J Biomed Biotech 2012; ID634195. DOI: 10.1155/2012/634195
14. Song Y, Wang L, Pittas AG et al. Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies. Diabetes Care 2013; 36 (5): 14221428. DOI: 10.2337/dc12-0962
15. Sung CC, Liao MT, Lu KC, Wu CC. Role of Vitamin D in Insulin Resistance. J Biomed Biotech 2012; ID634195. DOI: 10.1155/2012/634195
16. Bachali S, Dasu K, Ramalingam K, Naidu JN. Vitamin D deficiency and insulin resistance in normal and type 2 diabetes subjects. Indian J Clin Bioch 2013; 28 (1): 74–8. DOI: 10.1007/s12291-012-0239-2
17. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocrine J 2000; 47 (4): 383–91.
18. Begum N, Leitner W, Reusch JE et al. GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca (2+)-induced inhibition of insulin-stimulated glucose transport. J Biol Chem 1993; 268 (5): 3352–6.
19. Karonova T.L., Shmonina I.A., Andreeva A.T. et al. Vitamin D: the cause or the result of obesity? Consilium Medicum. 2016; 18 (4): 49–52. [in Russian]
20. Ishii H, Suzuki H, Baba T et al. Seasonal variation of glycemic control in type 2 diabetic patients. Diabetes Care 2001; 24 (8): 1503.
21. Liang WW. Seasonal changes in preprandial glucose, A1C, and blood pressure in diabetic patients. Diabetes Care 2007; 30 (10): 2501–2.
22. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey. Diabetes Care (2004); 27 (12): 2813–8.
23. Hyppönen E. 25-hydroxyvitamin D, IGF-I, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British cohort. Diabetes 2008; 57: 298–305.
24. Lu L, Yu Z, Pan A et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese. Diabetes Care 2009; 32 (7): 1278–83.
25. Pittas AG, Chung M, Tricalinos T et al. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010; 152: 307–14.
26. Randhawa FA, Mustafa S, Khan DM, Hamid S. Effect of Vitamin D supplementation on reduction in levels of HbA1 in patients recently diagnosed with type 2 Diabetes Mellitus having asymptomatic Vitamin D deficiency. Pakistan J Med Sci 2017; 33 (4); 881–5. DOI: 10.12669/pjms.334.12288
27. Mirhosseini N, Vatanparast H, Mazidi M, Kimball SM. The effect of improved serum 25-Hydroxyvitamin D status on glycemic control in diabetic patients: A Meta-Analysis. J Clin Endocrinol Metab 2017; 102 (9): 3097–10. DOI: 10.1210/jc.2017-01024
28. Hyppönen E. Intake of vitamin D and risk of type 1 diabetes: a birth–cohort study. Lancet 2001; 358: 1500–3.
29. Borissova AM, Tankova T, Kirillov G et al. The effect of vitamin D3 on insulin secretion and peripheral sensitivity in type 2 diabetic patients Int. J Clin Pract 2003; 57 (4): 258–61.
30. Chiu KC, Chu A, Go VLW et al. Hypovitaminosis D is associated with insulin resistance and b cell dysfunction. Am J Clin Nutr 2004; 79 (5): 820–5.
31. Avenell AA, Cook JA, MacLennan GS et al. Vitamin D supplementation and type 2 diabetes: a substudy of a randomized placebo-controlled trial in older people (RECORD trial, ISRCTN 5167438). Age Agening 2009; 38: 606–9.
32. Pittas AG. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006; 29 (3): 650–6.
Авторы
Т.Л.Каронова
ФГБУ «Национальный медицинский исследовательский центр им. В.А.Алмазова» Минздрава России. 197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2;
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова» Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8 karonova@mail.ru
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T.L.Karonova
V.A.Almazov National Medical Research Center of the Ministry of Health of the Russian Federation. 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2;
I.P.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, 6/8 karonova@mail.ru