Синдром тиреотоксикоза аутоиммунного генеза (клинический случай и обзор литературы)

2. http://thyronet.rusmedserv.com/spetsialistam/literatura/zabolevaniya-schitovidnoi-zhelezy-v-shemah/?....
3. Клинические рекомендации Российской ассоциации эндокринологов по диагностике и лечению тиреотоксикоза с диффузным зобом (диффузный токсический зоб, болезнь Грейвса–Базедова), узловым/многоузловым зобом. М., 2014. / Klinicheskie rekomendatsii Rossiiskoi assotsiatsii endokrinologov po diagnostike i lecheniiu tireotoksikoza s diffuznym zobom (diffuznyi toksicheskii zob, bolezn' Greivsa–Bazedova), uzlovym/mnogouzlovym zobom. M., 2014. [in Russian]
4. Burch HB, Burman KD, Cooper DS. A 2011 survey of clinical practice patterns in the management of Graves' disease. J Clin Endocrinol Metab 2012; 97 (12): 4549–58.
5. Hwa YA, Yun JC, Bo YC. Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence. Med (Baltimore) 2017; 96 (31): e7700. DOI: 10.1097/MD.0000000000007700
6. Fröhlich E, Wah R. Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases. Front Immunol 2017; 8: 521. DOI: 10.3389/fimmu.2017.00521
7. Дефицит витамина D у взрослых: диагностика, лечение и профилактика. Клинические рекомендации Российской ассоциации эндокринологов. М., 2015. / Defitsit vitamina D u vzroslykh: diagnostika, lechenie i profilaktika. Klinicheskie rekomendatsii Rossiiskoi assotsiatsii endokrinologov. M., 2015. [in Russian]
8. Pyzik A, Grywalska E, Matyjaszek-Matuszek B et al. Immune disorders in Hashimoto's thyroiditis: what do we know so far? J Immunol Res 2015: 979167. DOI: 10.1155/2015/979167
9. Kawashima A, Tanigawa K, Akama T et al. Innate immune activation and thyroid autoimmunity. J Clin Endocrinol Metab 2011; 96 (12): 3661–71. DOI: 10.1210/jc.2011-1568
10. Hiromatsu Y, Satoh H, Amino N. Hashimoto's thyroiditis: history and future outlook. Hormones (Athens) 2013; 12 (1): 12–8.
11. Li Y, Nishihara E, Hirokawa M et al. Distinct clinical, serological, and sonographic characteristics of hashimoto's thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab 2010; 95 (3): 1309–17.
12. Jara L, Vera-Lastra O, Medina G. Endocrine and reproductive autoimmune diseases. Atrophic thyroiditis. In: Shoenfeld Y, Cervera R, Gershwin M. Diagnostic Criteria in Autoimmune Diseases. Totowa, NJ: Humana Press, 2008; p. 221–6. 
13. Weetman AP. Graves' disease. N Engl J Med 2000; 343 (17): 1236–48.
14. De Luca F, Santucci S, Corica D et al. Hashimoto's thyroiditis in childhood: presentation modes and evolution over time. Ital J Pediatr 2013; 39: 8. DOI: 10.1186/1824-7288-39-8
15. Swain M, Swain T, Mohanty BK. Autoimmune thyroid disorders-An update. Indian J Clin Biochem 2005; 20 (1): 9–17.
16. Carlé A, Bülow Pedersen I et al. Graves' hyperthyroidism and moderate alcohol consumption: evidence for disease prevention. Clin Endocrinol (Oxf) 2013; 79 (1): 111–9. DOI: 10.1111/cen.12106
17. Zarković M. The role of oxidative stress on the pathogenesis of graves' disease. J Thyroid Res 2012: 302537. DOI: 10.1155/2012/30253
18. Desailloud R, Hober D. Viruses and thyroiditis: an update. Virol J 2009; 6: 5. DOI: 10.1186/1743-422X-6-5
19. Blackard JT, Kong L, Huber AK et al. Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis. Thyroid 2013; 23 (7): 863–70. DOI: 10.1089/thy.2012.0507
20. Wolf MW, Misaki T, Bech K et al. Immunoglobulins of patients recovering from Yersinia enterocolitica infections exhibit Graves' disease-like activity in human thyroid membranes. Thyroid 1991; 1 (4): 315–20. DOI: 10.1089/thy.1991.1.315
21. Mori K, Nakagawa Y, Ozaki H. Does the gut microbiota trigger Hashimoto's thyroiditis? Discov Med 2012; 14 (78): 321–6.
22. Davies TF. Infection and autoimmune thyroid disease. J Clin Endocrinol Metab 2008; 93 (3): 674–6. DOI: 10.1210/jc.2008-0095
23. Hansen PS, Brix TH, Iachine I et al. The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins. Eur J Endocrinol 2006; 154 (1): 29–38. DOI: 10.1530/eje.1.02060
24. Fairweather D, Frisancho-Kiss S, Rose NR. Sex differences in autoimmune disease from a pathological perspective. Am J Pathol 2008; 173 (3): 600–9. DOI: 10.2353/ajpath.2008.071008
25. Zandman-Goddard G, Peeva E, Shoenfeld Y. Gender and autoimmunity. Autoimmun Rev 2007; 6 (6): 366–72. DOI: 10.1016/j.autrev.2006.10.001
26. Effraimidis G, Wiersinga WM. Mechanisms in endocrinology: autoimmune thyroid disease: old and new players. Eur J Endocrinol 2014; 170 (6): R241–52. DOI: 10.1530/EJE-14-0047
27. Zalete K, Gaberšček S. Hashimoto's Thyroiditis: From Genes to the Disease. Curr Genomics 2011; 12 (8): 576–88. DOI: 10.2174/138920211798120763
28. Groer M, Jevitt C. Symptoms and signs associated with postpartum thyroiditis. J Thyroid Res 2014; 2014: 531969. DOI: 10.1155/2014/531969
29. Ngo ST, Steyn FJ, McCombe PA. Gender differences in autoimmune disease. Front Neuroendocrinol 2014; 35 (3): 347–69. DOI: 10.1016/j.yfrne.2014.04.004
30. Wang J, Lv S, Chen G et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015; 7 (4): 2485–98. DOI: 10.3390/nu7042485
31. Kim D. Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. Hormones (Athens) 2016; 15 (3): 385–93. DOI: 10.14310/horm.2002.1681
32. Ma J, Wu D, Li C et al. Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases. Medicine (Baltimore. 2015; 94 (39): e1639. DOI: 10.1097/MD.0000000000001639
33. Yasmeh J, Farpour F, Rizzo V et al. Нashimoto thyroiditis not associated with vitamin d deficiency. Endocr Pract 2016; 22 (7): 809–13. DOI: 10.4158/EP15934.OR
34. Kirsten VK, Ahmed AM, Mette B et al. Effect of Vitamin D on Thyroid Autoimmunity: A Randomized, Double-Blind, Controlled Trial Among Ethnic Minorities. J Endocr Soc 2017; 1 (5): 470–9. DOI: 10.1210/js.2017-00037
35. Yasuda T, Okamoto Y, Hamada N et al. Serum vitamin D levels are decreased in patients without remission of Graves' disease. Endocrine 2013; 43 (1): 230–2. DOI: 10.1007/s12020-012-9789-6
36. Samareh FM, Shokoohi M, Gozashti MH et al. Association between anti-thyroid peroxidase antibody and asthma in women. Iran J Allergy Asthma Immunol 2012; 11 (3): 241–5. DOI: 011.03/ijaai.241245
37. Nakamura H, Usa T, Motomura M et al. Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. J Endocrinol Invest 2008; 31 (10): 861–5. DOI: 10.1007/BF03346432
38. Shan SJ, Douglas RS. The pathophysiology of thyroid eye disease. J Neuroophthalmol 2014; 34 (2): 177–85. DOI: 10.1097/WNO.0000000000000132
39. Woo YJ, Jang SY, Lim TH et al. Clinical Association of Thyroid Stimulating Hormone Receptor Antibody Levels with Disease Severity in the Chronic Inactive Stage of Graves' Orbitopathy. Korean J Ophthalmol 2015; 29 (4): 213–9. DOI: 10.3341/kjo.2015.29.4.213
40. Reddy SV, Gupta SK, Jain M. Dermopathy of Graves' disease: Clinico-pathological correlation. Indian J Endocrinol Metab 2012; 16 (3): 460–2. DOI: 10.4103/2230-8210.95714
41. Dhali TK, Chahar M. Thyroid dermopathy-a diagnostic clue of hidden hyperthyroidism. Dermatoendocrinol 2014; 6 (1): e981078. DOI: 10.4161/19381980.2014.981078
42. Promberger R, Hermann M, Ott J. Hashimoto’s thyroiditis in patients with normal thyroid-stimulating hormone levels. Expert Rev Endocrinol Metab 2012; 7: 175–9. DOI: 10.1586/eem.12.3
43. Leyhe T, Müssig K. Cognitive and affective dysfunctions in autoimmune thyroiditis. Brain Behav Immun 2014; 41: 261–6. DOI: 10.1016/j.bbi.2014.03.008
44. Chiarella G, Tognini S, Nacci A et al. Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity. Clin Endocrinol (Oxf) 2014; 81 (4): 600–5. DOI: 10.1111/cen.12471
45. Seror J, Amand G, Guibourdenche J et al. Anti-TPO antibodies diffusion through the placental barrier during pregnancy. PLoS One 2014; 9 (1): e84647. DOI: 10.1371/journal.pone.0084647
46. Korevaar TI, Steegers EA, Pop VJ et al. Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies. J Clin Endocrinol Metab 2017; 102 (1): 69–77. DOI: 10.1210/jc.2016-2942
47. Wang GC, Talor MV, Rose NR et al. Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women. J Clin Endocrinol Metab 2010; 95 (3): 1161–8. DOI: 10.1210/jc.2009-1991
48. Qin J, Yu Z, Guan H et al. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Dis Markers 2015; 648670. DOI: 10.1155/2015/648670
49. Prinzi N, Sorrenti S, Baldini E et al. Association of thyroid diseases with primary extra-thyroidal malignancies in women: results of a cross-sectional study of 6,386 patients. PLoS One 2015; 10 (3): e0122958. DOI: 10.1371/journal.pone.0122958
50. Sarlis NJ, Gourgiotis L, Pucino F et al. Lack of association between Hashimoto thyroiditis and breast cancer: a quantitative research synthesis. Hormones (Athens) 2002; 1 (1): 35–41.
51. Brandt J, Borgquist S, Manjer J. Prospectively measured thyroid hormones and thyroid peroxidase antibodies in relation to risk of different breast cancer subgroups: a Malmö Diet and Cancer Study. Cancer Causes Control 2015; 26 (8): 1093–104. DOI: 10.1007/s10552-015-0602-8
52. Tosovic A, Bondeson AG, Bondeson L et al. Triiodothyronine levels in relation to mortality from breast cancer and all causes: a population-based prospective cohort study. Eur J Endocrinol 2013; 168 (4): 483–90. DOI: 10.1530/EJE-12-0564
53. Amiri-Kordestani L, Luchenko V, Peer CJ et al. Phase I trial of a new schedule of romidepsin in patients with advanced cancers. Clin Cancer Res 2013; 19 (16): 4499–507. DOI: 10.1158/1078-0432.CCR-13-0095
54. Ditsch N, Liebhardt S, Von Koch F et al. Thyroid function in breast cancer patients. Anticancer Res 2010; 30 (5): 1713–7.
56. Michalaki V, Kondi-Pafiti A, Gennatas S et al. Breast cancer in association with thyroid disorders. J BUON 2009; 14 (3): 425–8.
57. Aceves C, Anguiano B, Delgado G. Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neoplasia 2005; 10 (2): 189–96. DOI: 10.1007/s10911-005-5401-5
58. Fiore E, Giustarini E, Mammoli C et al. Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer. J Endocrinol Invest 2007; 30 (9): 734–8. DOI: 10.1007/BF03350810
59. Shi XZ, Jin X, Xu P et al. Relationship between breast cancer and levels of serum thyroid hormones and antibodies: a meta-analysis. Asian Pac J Cancer Prev 2014; 15 (16): 6643–7.
60. Hardefeldt PJ, Eslick GD, Edirimanne S. Benign thyroid disease is associated with breast cancer: a meta-analysis. Breast Cancer Res Treat 2012; 133 (3): 1169–77. DOI: 10.1007/s10549-012-2019-3
61. Kuijpens JL, Nyklíctek I, Louwman MW et al. Hypothyroidism might be related to breast cancer in post-menopausal women. Thyroid 2005; 15 (11): 1253–9. DOI: 10.1089/thy.2005.15.1253
62. Rapoport B, McLachlan S. Thyroid peroxidase as an autoantigen in autoimmune thyroid disease: update 1994. In: Negro-Vilar A, Braverman L, Refetoff S. Endocrine Review Monographs 3. Clinical and Molecular Aspects of Diseases of the Thyroid. Bethesda, MD: The Endocrine Society, 1994; p. 96–102.
63. Seker S, Tas I. Determination of thyroid volume and its relation with isthmus thickness. Eur J Gen Med 2010; 7: 125–9.
64. Kemal Y, Demirag G, Ekiz K et al. Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer. Mol Clin Oncol 2015; 3 (3): 629–32. DOI: 10.3892/mco.2015.521
65. Özmen T, Güllüoğlu BM, Yegen CȘ et al. Autoimmune Thyroid Disease and Breast Cancer Prognosis. J Breast Health 2015; 11 (2): 67–71. DOI: 10.5152/tjbh.2015.2462
66. Jiskra J, Barkmanova J, Limanova Z et al. Thyroid autoimmunity occurs more frequently in women with breast cancer compared to women with colorectal cancer and controls but it has no impact on relapse-free and overall survival. Oncol Rep 2007; 18 (6): 1603–11.
67. Anguiano B, García-Solís P, Delgado G et al. Uptake and gene expression with antitumoral doses of iodine in thyroid and mammary gland: evidence that chronic administration has no harmful effects. Thyroid 2007; 17 (9): 851–9. DOI: 10.1089/thy.2007.0122
68. Shrivastava A, Tiwari M, Sinha RA et al. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem 2006; 281 (28): 19762–71. DOI: 10.1074/jbc.M600746200

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1. Endokrinologiia. Natsional'noe rukovodstvo. Kratkoe izdanie. Pod red. I.I.Dedova, G.A.Mel'nichenko. M.: GEOTAR-Media, 2013. [in Russian]
2. http://thyronet.rusmedserv.com/spetsialistam/literatura/zabolevaniya-schitovidnoi-zhelezy-v-shemah/?....
3. Klinicheskie rekomendatsii Rossiiskoi assotsiatsii endokrinologov po diagnostike i lecheniiu tireotoksikoza s diffuznym zobom (diffuznyi toksicheskii zob, bolezn' Greivsa–Bazedova), uzlovym/mnogouzlovym zobom. M., 2014. [in Russian]
4. Burch HB, Burman KD, Cooper DS. A 2011 survey of clinical practice patterns in the management of Graves' disease. J Clin Endocrinol Metab 2012; 97 (12): 4549–58.
5. Hwa YA, Yun JC, Bo YC. Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence. Med (Baltimore) 2017; 96 (31): e7700. DOI: 10.1097/MD.0000000000007700
6. Fröhlich E, Wah R. Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases. Front Immunol 2017; 8: 521. DOI: 10.3389/fimmu.2017.00521
7. Defitsit vitamina D u vzroslykh: diagnostika, lechenie i profilaktika. Klinicheskie rekomendatsii Rossiiskoi assotsiatsii endokrinologov. M., 2015. [in Russian]
8. Pyzik A, Grywalska E, Matyjaszek-Matuszek B et al. Immune disorders in Hashimoto's thyroiditis: what do we know so far? J Immunol Res 2015: 979167. DOI: 10.1155/2015/979167
9. Kawashima A, Tanigawa K, Akama T et al. Innate immune activation and thyroid autoimmunity. J Clin Endocrinol Metab 2011; 96 (12): 3661–71. DOI: 10.1210/jc.2011-1568
10. Hiromatsu Y, Satoh H, Amino N. Hashimoto's thyroiditis: history and future outlook. Hormones (Athens) 2013; 12 (1): 12–8.
11. Li Y, Nishihara E, Hirokawa M et al. Distinct clinical, serological, and sonographic characteristics of hashimoto's thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab 2010; 95 (3): 1309–17.
12. Jara L, Vera-Lastra O, Medina G. Endocrine and reproductive autoimmune diseases. Atrophic thyroiditis. In: Shoenfeld Y, Cervera R, Gershwin M. Diagnostic Criteria in Autoimmune Diseases. Totowa, NJ: Humana Press, 2008; p. 221–6. 
13. Weetman AP. Graves' disease. N Engl J Med 2000; 343 (17): 1236–48.
14. De Luca F, Santucci S, Corica D et al. Hashimoto's thyroiditis in childhood: presentation modes and evolution over time. Ital J Pediatr 2013; 39: 8. DOI: 10.1186/1824-7288-39-8
15. Swain M, Swain T, Mohanty BK. Autoimmune thyroid disorders-An update. Indian J Clin Biochem 2005; 20 (1): 9–17.
16. Carlé A, Bülow Pedersen I et al. Graves' hyperthyroidism and moderate alcohol consumption: evidence for disease prevention. Clin Endocrinol (Oxf) 2013; 79 (1): 111–9. DOI: 10.1111/cen.12106
17. Zarković M. The role of oxidative stress on the pathogenesis of graves' disease. J Thyroid Res 2012: 302537. DOI: 10.1155/2012/30253
18. Desailloud R, Hober D. Viruses and thyroiditis: an update. Virol J 2009; 6: 5. DOI: 10.1186/1743-422X-6-5
19. Blackard JT, Kong L, Huber AK et al. Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis. Thyroid 2013; 23 (7): 863–70. DOI: 10.1089/thy.2012.0507
20. Wolf MW, Misaki T, Bech K et al. Immunoglobulins of patients recovering from Yersinia enterocolitica infections exhibit Graves' disease-like activity in human thyroid membranes. Thyroid 1991; 1 (4): 315–20. DOI: 10.1089/thy.1991.1.315
21. Mori K, Nakagawa Y, Ozaki H. Does the gut microbiota trigger Hashimoto's thyroiditis? Discov Med 2012; 14 (78): 321–6.
22. Davies TF. Infection and autoimmune thyroid disease. J Clin Endocrinol Metab 2008; 93 (3): 674–6. DOI: 10.1210/jc.2008-0095
23. Hansen PS, Brix TH, Iachine I et al. The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins. Eur J Endocrinol 2006; 154 (1): 29–38. DOI: 10.1530/eje.1.02060
24. Fairweather D, Frisancho-Kiss S, Rose NR. Sex differences in autoimmune disease from a pathological perspective. Am J Pathol 2008; 173 (3): 600–9. DOI: 10.2353/ajpath.2008.071008
25. Zandman-Goddard G, Peeva E, Shoenfeld Y. Gender and autoimmunity. Autoimmun Rev 2007; 6 (6): 366–72. DOI: 10.1016/j.autrev.2006.10.001
26. Effraimidis G, Wiersinga WM. Mechanisms in endocrinology: autoimmune thyroid disease: old and new players. Eur J Endocrinol 2014; 170 (6): R241–52. DOI: 10.1530/EJE-14-0047
27. Zalete K, Gaberšček S. Hashimoto's Thyroiditis: From Genes to the Disease. Curr Genomics 2011; 12 (8): 576–88. DOI: 10.2174/138920211798120763
28. Groer M, Jevitt C. Symptoms and signs associated with postpartum thyroiditis. J Thyroid Res 2014; 2014: 531969. DOI: 10.1155/2014/531969
29. Ngo ST, Steyn FJ, McCombe PA. Gender differences in autoimmune disease. Front Neuroendocrinol 2014; 35 (3): 347–69. DOI: 10.1016/j.yfrne.2014.04.004
30. Wang J, Lv S, Chen G et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015; 7 (4): 2485–98. DOI: 10.3390/nu7042485
31. Kim D. Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. Hormones (Athens) 2016; 15 (3): 385–93. DOI: 10.14310/horm.2002.1681
32. Ma J, Wu D, Li C et al. Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases. Medicine (Baltimore. 2015; 94 (39): e1639. DOI: 10.1097/MD.0000000000001639
33. Yasmeh J, Farpour F, Rizzo V et al. Нashimoto thyroiditis not associated with vitamin d deficiency. Endocr Pract 2016; 22 (7): 809–13. DOI: 10.4158/EP15934.OR
34. Kirsten VK, Ahmed AM, Mette B et al. Effect of Vitamin D on Thyroid Autoimmunity: A Randomized, Double-Blind, Controlled Trial Among Ethnic Minorities. J Endocr Soc 2017; 1 (5): 470–9. DOI: 10.1210/js.2017-00037
35. Yasuda T, Okamoto Y, Hamada N et al. Serum vitamin D levels are decreased in patients without remission of Graves' disease. Endocrine 2013; 43 (1): 230–2. DOI: 10.1007/s12020-012-9789-6
36. Samareh FM, Shokoohi M, Gozashti MH et al. Association between anti-thyroid peroxidase antibody and asthma in women. Iran J Allergy Asthma Immunol 2012; 11 (3): 241–5. DOI: 011.03/ijaai.241245
37. Nakamura H, Usa T, Motomura M et al. Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. J Endocrinol Invest 2008; 31 (10): 861–5. DOI: 10.1007/BF03346432
38. Shan SJ, Douglas RS. The pathophysiology of thyroid eye disease. J Neuroophthalmol 2014; 34 (2): 177–85. DOI: 10.1097/WNO.0000000000000132
39. Woo YJ, Jang SY, Lim TH et al. Clinical Association of Thyroid Stimulating Hormone Receptor Antibody Levels with Disease Severity in the Chronic Inactive Stage of Graves' Orbitopathy. Korean J Ophthalmol 2015; 29 (4): 213–9. DOI: 10.3341/kjo.2015.29.4.213
40. Reddy SV, Gupta SK, Jain M. Dermopathy of Graves' disease: Clinico-pathological correlation. Indian J Endocrinol Metab 2012; 16 (3): 460–2. DOI: 10.4103/2230-8210.95714
41. Dhali TK, Chahar M. Thyroid dermopathy-a diagnostic clue of hidden hyperthyroidism. Dermatoendocrinol 2014; 6 (1): e981078. DOI: 10.4161/19381980.2014.981078
42. Promberger R, Hermann M, Ott J. Hashimoto’s thyroiditis in patients with normal thyroid-stimulating hormone levels. Expert Rev Endocrinol Metab 2012; 7: 175–9. DOI: 10.1586/eem.12.3
43. Leyhe T, Müssig K. Cognitive and affective dysfunctions in autoimmune thyroiditis. Brain Behav Immun 2014; 41: 261–6. DOI: 10.1016/j.bbi.2014.03.008
44. Chiarella G, Tognini S, Nacci A et al. Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity. Clin Endocrinol (Oxf) 2014; 81 (4): 600–5. DOI: 10.1111/cen.12471
45. Seror J, Amand G, Guibourdenche J et al. Anti-TPO antibodies diffusion through the placental barrier during pregnancy. PLoS One 2014; 9 (1): e84647. DOI: 10.1371/journal.pone.0084647
46. Korevaar TI, Steegers EA, Pop VJ et al. Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies. J Clin Endocrinol Metab 2017; 102 (1): 69–77. DOI: 10.1210/jc.2016-2942
47. Wang GC, Talor MV, Rose NR et al. Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women. J Clin Endocrinol Metab 2010; 95 (3): 1161–8. DOI: 10.1210/jc.2009-1991
48. Qin J, Yu Z, Guan H et al. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Dis Markers 2015; 648670. DOI: 10.1155/2015/648670
49. Prinzi N, Sorrenti S, Baldini E et al. Association of thyroid diseases with primary extra-thyroidal malignancies in women: results of a cross-sectional study of 6,386 patients. PLoS One 2015; 10 (3): e0122958. DOI: 10.1371/journal.pone.0122958
50. Sarlis NJ, Gourgiotis L, Pucino F et al. Lack of association between Hashimoto thyroiditis and breast cancer: a quantitative research synthesis. Hormones (Athens) 2002; 1 (1): 35–41.
51. Brandt J, Borgquist S, Manjer J. Prospectively measured thyroid hormones and thyroid peroxidase antibodies in relation to risk of different breast cancer subgroups: a Malmö Diet and Cancer Study. Cancer Causes Control 2015; 26 (8): 1093–104. DOI: 10.1007/s10552-015-0602-8
52. Tosovic A, Bondeson AG, Bondeson L et al. Triiodothyronine levels in relation to mortality from breast cancer and all causes: a population-based prospective cohort study. Eur J Endocrinol 2013; 168 (4): 483–90. DOI: 10.1530/EJE-12-0564
53. Amiri-Kordestani L, Luchenko V, Peer CJ et al. Phase I trial of a new schedule of romidepsin in patients with advanced cancers. Clin Cancer Res 2013; 19 (16): 4499–507. DOI: 10.1158/1078-0432.CCR-13-0095
54. Ditsch N, Liebhardt S, Von Koch F et al. Thyroid function in breast cancer patients. Anticancer Res 2010; 30 (5): 1713–7.
55. Mattar MC, Lough D, Pishvaian MJ et al. Current management of inflammatory bowel disease and colorectal cancer. Gastrointest Cancer Res 2011; 4 (2): 53–61.
56. Michalaki V, Kondi-Pafiti A, Gennatas S et al. Breast cancer in association with thyroid disorders. J BUON 2009; 14 (3): 425–8.
57. Aceves C, Anguiano B, Delgado G. Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neoplasia 2005; 10 (2): 189–96. DOI: 10.1007/s10911-005-5401-5
58. Fiore E, Giustarini E, Mammoli C et al. Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer. J Endocrinol Invest 2007; 30 (9): 734–8. DOI: 10.1007/BF03350810
59. Shi XZ, Jin X, Xu P et al. Relationship between breast cancer and levels of serum thyroid hormones and antibodies: a meta-analysis. Asian Pac J Cancer Prev 2014; 15 (16): 6643–7.
60. Hardefeldt PJ, Eslick GD, Edirimanne S. Benign thyroid disease is associated with breast cancer: a meta-analysis. Breast Cancer Res Treat 2012; 133 (3): 1169–77. DOI: 10.1007/s10549-012-2019-3
61. Kuijpens JL, Nyklíctek I, Louwman MW et al. Hypothyroidism might be related to breast cancer in post-menopausal women. Thyroid 2005; 15 (11): 1253–9. DOI: 10.1089/thy.2005.15.1253
62. Rapoport B, McLachlan S. Thyroid peroxidase as an autoantigen in autoimmune thyroid disease: update 1994. In: Negro-Vilar A, Braverman L, Refetoff S. Endocrine Review Monographs 3. Clinical and Molecular Aspects of Diseases of the Thyroid. Bethesda, MD: The Endocrine Society, 1994; p. 96–102.
63. Seker S, Tas I. Determination of thyroid volume and its relation with isthmus thickness. Eur J Gen Med 2010; 7: 125–9.
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М.В.Алташина1, Е.А.Панфилова1, М.А.Терехова2, Е.А.Трошина*1

*troshina@inbox.ru

________________________________________________

1 National Medical Research Center of the Endocrinology of the Ministry of Health of the Russian Federation. 117036, Russian Federation, Moscow, ul. Dmitria Ul'ianova, d. 11;
2 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia d. 8, str. 1
*troshina@inbox.ru