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Терапевтические возможности коррекции дефицита витамина D у взрослых
Терапевтические возможности коррекции дефицита витамина D у взрослых
Пигарова Е.А., Петрушкина А.А. Терапевтические возможности коррекции дефицита витамина D у взрослых. Consilium Medicum. 2018; 20 (4): 43–46. DOI: 10.26442/2075-1753_2018.4.43-46
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Аннотация
Дефицит витамина D является патологическим состоянием, которое вносит нарушения не только в метаболизм костной ткани, но и во многие другие физиологические процессы ввиду наличия у витамина D множества внекостных эффектов. В то же время распространенность этого состояния очень высока. Поддержание адекватного уровня витамина D является важным для функционирования большинства тканей и систем организма и поддержания оптимального состояния здоровья у людей всех возрастов. Данная статья посвящена терапевтическим возможностям коррекции дефицита витамина D у взрослых.
Ключевые слова: дефицит витамина D, колекальциферол.________________________________________________
Due to various extraskeletal effects of vitamin D, vitamin D deficiency is a pathologic condition which affects not only bone health, but disturbes a lot of physiologic processes. It is a pandemic condition at the same time. Maintaining adequate vitamin D status is essential for people of all ages. In this article we discuss treatment options of vitamin D deficiency in adults.
Key words: vitamin D deficiency, cholecalciferol.
Key words: vitamin D deficiency, cholecalciferol.
Полный текст
Список литературы
1. Громова О.А., Торшин И.Ю. Витамин D. Смена парадигмы. Под ред. Е.И.Гусева, И.Н.Захаровой. М., 2015. / Gromova O.A., Torshin I.Iu. Vitamin D. Smena paradigmy. Pod red. E.I.Guseva, I.N.Zakharovoi. M., 2015. [in Russian]
2. Meir T, Levi R, Lieben L et al. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Renal Physiol 2009; 297 (5): F1192–8.
3. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96 (7): 1911–30.
4. Holick MF. Vitamin D: Extraskeletal health. Endocrinol Metab Clin North Am 2010; 39 (2): 381–400.
5. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е. и др. Клинические рекомендации Российской Ассоциации Эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016; 62 (4): 60–84. / Pigarova E.A., Rozhinskaia L.Ia., Belaia Zh.E. i dr. Klinicheskie rekomendatsii Rossiiskoi Assotsiatsii Endokrinologov po diagnostike, lecheniiu i profilaktike defitsita vitamina D u vzroslykh. Problemy endokrinologii. 2016; 62 (4): 60–84. [in Russian]
6. Soleymani T, Hung T, Soung J. The role of vitamin D in psoriasis: A review. Int J Dermatol 2015; 54 (4): 383–92. 2. Meir T, Levi R, Lieben L et al. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Renal Physiol 2009; 297 (5): F1192–8.
3. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96 (7): 1911–30.
4. Holick MF. Vitamin D: Extraskeletal health. Endocrinol Metab Clin North Am 2010; 39 (2): 381–400.
5. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е. и др. Клинические рекомендации Российской Ассоциации Эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016; 62 (4): 60–84. / Pigarova E.A., Rozhinskaia L.Ia., Belaia Zh.E. i dr. Klinicheskie rekomendatsii Rossiiskoi Assotsiatsii Endokrinologov po diagnostike, lecheniiu i profilaktike defitsita vitamina D u vzroslykh. Problemy endokrinologii. 2016; 62 (4): 60–84. [in Russian]
7. Kim MJ, Kim S-N, Lee YW et al. Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: A systematic review and meta-analysis. Nutrients 2016; 8 (12): E789.
8. Wöbke TK, Sorg BL, Steinhilber D. Vitamin D in inflammatory diseases. Front Physiol 2014; 5: 244.
9. Lee YH, Bae S-C. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis. Clin Exp Rheumatol 2016; 34: 827–33.
10. Simsek Y, Cakir I, Yetmis M et al. Effects of vitamin D treatment on thyroid autoimmunity. J Res Med Sci 2016; 21: 85.
11. Munger KL, Levin LI, Hollis BW et al. Serum 25-Hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296 (23): 2832–8.
12. Chakhtoura M, Azar ST. The role of vitamin D deficiency in the incidence, progression and complications of type 1 diabetes mellitus. Int J Endocrinol 2013; 2013: 148673.
13. Martineau A, Jolliffe D, Hooper R et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of individual participant data. Br Med J 2017; 536: i6583.
14. Zittermann A, Pilz S, Hoffmann H, März W. Vitamin D and airway infections: a European perspective. Eur J Med Res 2016; 21: 14.
15. Rosen CJ, Adams JS, Bikle DD et al. The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocr Rev 2012; 33 (3): 456–92.
16. Pilz S, Kienreich K, Rutters F et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep 2013; 13 (2): 261–70.
17. Zhou S-S, Tao Y-H, Huang K et al. Vitamin D and risk of preterm birth: Up-to-date meta-analysis of randomized controlled trials and observational studies. J Obstet Gynaecol Res 2017; 43 (2): 247–56.
18. Lu M, Xu Y, Lv L, Zhang M. Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet 2016; 293 (5): 959–66.
19. Aghajafari F, Nagulesapillai T, Ronksley PE et. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. Br Med J 2013; 346: f1169.
20. Wei S-Q, Qi H-P, Luo Z-C, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013; 26 (9): 889–99.
21. Murad MH, Elamin KB, Abu Elnour NO et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab 2011; 96 (10): 2997–3006.
22. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988; 67 (2): 373–8.
23. Engelsen O, Brustad M, Aksnes L, Lund E. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 2005; 81 (6): 1287–90.
24. Плещева А.В., Пигарова Е.А., Дзеранова Л.К. Витамин D и метаболизм: факты, мифы и предубеждения. Ожирение и метаболизм. 2012; 9 (2): 33–42. / Pleshcheva A.V., Pigarova E.A., Dzeranova L.K. Vitamin D i metabolizm: fakty, mify i predubezhdeniia. Ozhirenie i metabolizm. 2012; 9 (2): 33–42. [in Russian]
25. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press, 2011.
26. Каронова Т.Л., Гринева Е.Н., Никитина И.Л. и др. Уровень обеспеченности витамином D жителей Северо-Западного региона РФ (г. Санкт-Петербург и г. Петрозаводск). Остеопороз и остеопатии. 2013; 3: 3–7. / Karonova T.L., Grineva E.N., Nikitina I.L. i dr. Uroven' obespechennosti vitaminom D zhitelei Severo-Zapadnogo regiona RF (g. Sankt-Peterburg i g. Petrozavodsk). Osteoporoz i osteopatii. 2013; 3: 3–7. [in Russian]
27. Лесняк О.М., Никитинская О.А., Торопцова Н.В. и др. Профилактика, диагностика и лечение дефицита витамина D и кальция у взрослого населения России и пациентов с остеопорозом (по материалам подготовленных клинических рекомендаций). Научно-практическая ревматология. 2015; 53 (4): 403–8. / Lesniak O.M., Nikitinskaia O.A., Toroptsova N.V. i dr. Profilaktika, diagnostika i lechenie defitsita vitamina D i kal'tsiia u vzroslogo naseleniia Rossii i patsientov s osteoporozom (po materialam podgotovlennykh klinicheskikh rekomendatsii). Nauchno-prakticheskaia revmatologiia. 2015; 53 (4): 403–8. [in Russian]
28. Национальная программа «Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции» (проект). М., 2017. / Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii” (proekt). M., 2017. [in Russian]
29. Луценко А.С., Рожинская Л.Я., Торопцова Н.В., Белая Ж.Е. Роль и место препаратов кальция и витамина D для профилактики и лечения остеопороза. Остеопороз и остеопатии. 2017; 20 (2): 69–75. / Lutsenko A.S., Rozhinskaia L.Ia., Toroptsova N.V., Belaia Zh.E. Rol' i mesto preparatov kal'tsiia i vitamina D dlia profilaktiki i lecheniia osteoporoza. Osteoporoz i osteopatii. 2017; 20 (2): 69–75. [in Russian]
30. International Osteoporosis Foundation. Calcium calculator [Internet]. http://www.iofbonehealth.org/calcium-calculator
________________________________________________
1. Gromova O.A., Torshin I.Iu. Vitamin D. Smena paradigmy. Pod red. E.I.Guseva, I.N.Zakharovoi. M., 2015. [in Russian]
2. Meir T, Levi R, Lieben L et al. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Renal Physiol 2009; 297 (5): F1192–8.
3. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96 (7): 1911–30.
4. Holick MF. Vitamin D: Extraskeletal health. Endocrinol Metab Clin North Am 2010; 39 (2): 381–400.
5. Pigarova E.A., Rozhinskaia L.Ia., Belaia Zh.E. i dr. Klinicheskie rekomendatsii Rossiiskoi Assotsiatsii Endokrinologov po diagnostike, lecheniiu i profilaktike defitsita vitamina D u vzroslykh. Problemy endokrinologii. 2016; 62 (4): 60–84. [in Russian]
6. Soleymani T, Hung T, Soung J. The role of vitamin D in psoriasis: A review. Int J Dermatol 2015; 54 (4): 383–92.
7. Kim MJ, Kim S-N, Lee YW et al. Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: A systematic review and meta-analysis. Nutrients 2016; 8 (12): E789.
8. Wöbke TK, Sorg BL, Steinhilber D. Vitamin D in inflammatory diseases. Front Physiol 2014; 5: 244.
9. Lee YH, Bae S-C. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis. Clin Exp Rheumatol 2016; 34: 827–33.
10. Simsek Y, Cakir I, Yetmis M et al. Effects of vitamin D treatment on thyroid autoimmunity. J Res Med Sci 2016; 21: 85.
11. Munger KL, Levin LI, Hollis BW et al. Serum 25-Hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296 (23): 2832–8.
12. Chakhtoura M, Azar ST. The role of vitamin D deficiency in the incidence, progression and complications of type 1 diabetes mellitus. Int J Endocrinol 2013; 2013: 148673.
13. Martineau A, Jolliffe D, Hooper R et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of individual participant data. Br Med J 2017; 536: i6583.
14. Zittermann A, Pilz S, Hoffmann H, März W. Vitamin D and airway infections: a European perspective. Eur J Med Res 2016; 21: 14.
15. Rosen CJ, Adams JS, Bikle DD et al. The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocr Rev 2012; 33 (3): 456–92.
16. Pilz S, Kienreich K, Rutters F et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep 2013; 13 (2): 261–70.
17. Zhou S-S, Tao Y-H, Huang K et al. Vitamin D and risk of preterm birth: Up-to-date meta-analysis of randomized controlled trials and observational studies. J Obstet Gynaecol Res 2017; 43 (2): 247–56.
18. Lu M, Xu Y, Lv L, Zhang M. Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet 2016; 293 (5): 959–66.
19. Aghajafari F, Nagulesapillai T, Ronksley PE et. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. Br Med J 2013; 346: f1169.
20. Wei S-Q, Qi H-P, Luo Z-C, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013; 26 (9): 889–99.
21. Murad MH, Elamin KB, Abu Elnour NO et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab 2011; 96 (10): 2997–3006.
22. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988; 67 (2): 373–8.
23. Engelsen O, Brustad M, Aksnes L, Lund E. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 2005; 81 (6): 1287–90.
24. Pleshcheva A.V., Pigarova E.A., Dzeranova L.K. Vitamin D i metabolizm: fakty, mify i predubezhdeniia. Ozhirenie i metabolizm. 2012; 9 (2): 33–42. [in Russian]
25. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press, 2011.
26. Karonova T.L., Grineva E.N., Nikitina I.L. i dr. Uroven' obespechennosti vitaminom D zhitelei Severo-Zapadnogo regiona RF (g. Sankt-Peterburg i g. Petrozavodsk). Osteoporoz i osteopatii. 2013; 3: 3–7. [in Russian]
27. Lesniak O.M., Nikitinskaia O.A., Toroptsova N.V. i dr. Profilaktika, diagnostika i lechenie defitsita vitamina D i kal'tsiia u vzroslogo naseleniia Rossii i patsientov s osteoporozom (po materialam podgotovlennykh klinicheskikh rekomendatsii). Nauchno-prakticheskaia revmatologiia. 2015; 53 (4): 403–8. [in Russian]
28. Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii” (proekt). M., 2017. [in Russian]
29. Lutsenko A.S., Rozhinskaia L.Ia., Toroptsova N.V., Belaia Zh.E. Rol' i mesto preparatov kal'tsiia i vitamina D dlia profilaktiki i lecheniia osteoporoza. Osteoporoz i osteopatii. 2017; 20 (2): 69–75. [in Russian]
30. International Osteoporosis Foundation. Calcium calculator [Internet]. http://www.iofbonehealth.org/calcium-calculator
2. Meir T, Levi R, Lieben L et al. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Renal Physiol 2009; 297 (5): F1192–8.
3. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96 (7): 1911–30.
4. Holick MF. Vitamin D: Extraskeletal health. Endocrinol Metab Clin North Am 2010; 39 (2): 381–400.
5. Pigarova E.A., Rozhinskaia L.Ia., Belaia Zh.E. i dr. Klinicheskie rekomendatsii Rossiiskoi Assotsiatsii Endokrinologov po diagnostike, lecheniiu i profilaktike defitsita vitamina D u vzroslykh. Problemy endokrinologii. 2016; 62 (4): 60–84. [in Russian]
6. Soleymani T, Hung T, Soung J. The role of vitamin D in psoriasis: A review. Int J Dermatol 2015; 54 (4): 383–92.
7. Kim MJ, Kim S-N, Lee YW et al. Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: A systematic review and meta-analysis. Nutrients 2016; 8 (12): E789.
8. Wöbke TK, Sorg BL, Steinhilber D. Vitamin D in inflammatory diseases. Front Physiol 2014; 5: 244.
9. Lee YH, Bae S-C. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis. Clin Exp Rheumatol 2016; 34: 827–33.
10. Simsek Y, Cakir I, Yetmis M et al. Effects of vitamin D treatment on thyroid autoimmunity. J Res Med Sci 2016; 21: 85.
11. Munger KL, Levin LI, Hollis BW et al. Serum 25-Hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296 (23): 2832–8.
12. Chakhtoura M, Azar ST. The role of vitamin D deficiency in the incidence, progression and complications of type 1 diabetes mellitus. Int J Endocrinol 2013; 2013: 148673.
13. Martineau A, Jolliffe D, Hooper R et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of individual participant data. Br Med J 2017; 536: i6583.
14. Zittermann A, Pilz S, Hoffmann H, März W. Vitamin D and airway infections: a European perspective. Eur J Med Res 2016; 21: 14.
15. Rosen CJ, Adams JS, Bikle DD et al. The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocr Rev 2012; 33 (3): 456–92.
16. Pilz S, Kienreich K, Rutters F et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep 2013; 13 (2): 261–70.
17. Zhou S-S, Tao Y-H, Huang K et al. Vitamin D and risk of preterm birth: Up-to-date meta-analysis of randomized controlled trials and observational studies. J Obstet Gynaecol Res 2017; 43 (2): 247–56.
18. Lu M, Xu Y, Lv L, Zhang M. Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet 2016; 293 (5): 959–66.
19. Aghajafari F, Nagulesapillai T, Ronksley PE et. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. Br Med J 2013; 346: f1169.
20. Wei S-Q, Qi H-P, Luo Z-C, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013; 26 (9): 889–99.
21. Murad MH, Elamin KB, Abu Elnour NO et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab 2011; 96 (10): 2997–3006.
22. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988; 67 (2): 373–8.
23. Engelsen O, Brustad M, Aksnes L, Lund E. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 2005; 81 (6): 1287–90.
24. Pleshcheva A.V., Pigarova E.A., Dzeranova L.K. Vitamin D i metabolizm: fakty, mify i predubezhdeniia. Ozhirenie i metabolizm. 2012; 9 (2): 33–42. [in Russian]
25. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press, 2011.
26. Karonova T.L., Grineva E.N., Nikitina I.L. i dr. Uroven' obespechennosti vitaminom D zhitelei Severo-Zapadnogo regiona RF (g. Sankt-Peterburg i g. Petrozavodsk). Osteoporoz i osteopatii. 2013; 3: 3–7. [in Russian]
27. Lesniak O.M., Nikitinskaia O.A., Toroptsova N.V. i dr. Profilaktika, diagnostika i lechenie defitsita vitamina D i kal'tsiia u vzroslogo naseleniia Rossii i patsientov s osteoporozom (po materialam podgotovlennykh klinicheskikh rekomendatsii). Nauchno-prakticheskaia revmatologiia. 2015; 53 (4): 403–8. [in Russian]
28. Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii” (proekt). M., 2017. [in Russian]
29. Lutsenko A.S., Rozhinskaia L.Ia., Toroptsova N.V., Belaia Zh.E. Rol' i mesto preparatov kal'tsiia i vitamina D dlia profilaktiki i lecheniia osteoporoza. Osteoporoz i osteopatii. 2017; 20 (2): 69–75. [in Russian]
30. International Osteoporosis Foundation. Calcium calculator [Internet]. http://www.iofbonehealth.org/calcium-calculator
Авторы
Е.А.Пигарова*, А.А.Петрушкина
ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России. 117036, Россия, Москва, ул. Дмитрия Ульянова, д. 11
*kpigarova@gmail.com
*kpigarova@gmail.com
ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России. 117036, Россия, Москва, ул. Дмитрия Ульянова, д. 11
________________________________________________
E.A.Pigarova*, A.A.Petrushkina
Endocrinology Research Centre of the Ministry of Health of the Russian Federation. 117036, Russian Federation, Moscow, ul. Dmitria Ul'ianova, d. 11*kpigarova@gmail.com
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