2. Гулевская Т.С., Моргунов В.А. Патологическая анатомия нарушений мозгового кровообращения при атеросклерозе и артериальной гипертензии. М.: Медицина, 2009. / Gulevskaia T.S., Morgunov V.A. Patologicheskaia anatomiia narushenii mozgovogo krovoobrashcheniia pri ateroskleroze i arterial'noi gipertenzii. M.: Meditsina, 2009. [in Russian]
3. Nishimura N, Rosidi NL, Iadecola C, Schaffer CB. Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. J Cereb Blood Flow Metab 2010; 30: 1914–27. http://doi.org/10.1038/jcbfm.2010.157
4. Kampoli AM, Tousoulis D, Briasoulis A et al. Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus. Curr Pharm Des 2011; 17 (37): 4147–58.
5. McLauchlan D, Malik GA, Robertson NP. Cerebral amyloid angiopathy: subtypes, treatment and role in cognitive impairment. J Neurol 2017; 264: 2184–6. https://doi.org/10.1007/s00415-017-8608-7
6. Cooper L, Woodard T, Sigurdsson S et al. Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory. Hypertension 2016; 67: 176–82. https://doi.org/10.1161/HYPERTENSIONAHA.115.06398
7. Pase MP, Himali JJ, Mitchell GF et al. Association of aortic stiffness with cognition and brain aging in young and middle-aged adults: the Framingham third generation cohort study. Hypertension 2016; 67 (3): 513–9. https://doi.org/10.1161/HYPERTENSIONAHA.115.06610
8. Prystowsky EN, Padanilam BJ. Preserve the Brain: Primary Goal in the Therapy of Atrial Fibrillation. J Am Coll Cardiol 2013; 62 (6): 540–2. DOI: 10.1016/j.jacc.2013.04.038
9. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ 2018; 361: k1675. https://doi.org/10.1136/bmj.k1675 
10. Gusev E, Skvortsova V. Brain Ischemia. New York-Boston-Dordecht-London: Kluwer Academic/Plenum Publishers, 2003.
11. Кузин В.М. Карнитина хлорид (25 лет в клинической практике). РМЖ. 2003; 11 (10): 5–9. / Kuzin V.M. Karnitina khlorid (25 let v klinicheskoi praktike). RMZh. 2003; 11 (10): 5–9. [in Russian]
12. Суслина З.А., Федорова Т.Н., Максимова М.Ю., Ким Е.К. Антиоксидантная активность милдроната и L-карнитина при лечении пациентов с цереброваскулярными заболеваниями. Эксп. клин. фарм. 2003; 66 (3): 32–5. / Suslina Z.A., Fedorova T.N., Maksimova M.Iu., Kim E.K. Antioksidantnaia aktivnost' mildronata i L-karnitina pri lechenii patsientov s tserebrovaskuliarnymi zabolevaniiami. Eksp. klin. farm. 2003; 66 (3): 32–5. [in Russian]
13. McMackin C, Widlansky M, Hamburg N et al. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich) 2007; 9 (4): 249–55.
14. Volek J, Judelson D, Silvestre R et al. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Am J Cardiol 2008; 102 (10): 1413–7.
15. Гусев Е.И., Кузин В.М., Колесникова Т.Н. и др. Карнитин – ведущий фактор регенерации нервной ткани. Мед. информационный вестн. 1999 (февраль): с. 11–23. / Gusev E.I., Kuzin V.M., Kolesnikova T.N. i dr. Karnitin – vedushchii faktor regeneratsii nervnoi tkani. Med. informatsionnyi vestn. 1999 (fevral'): s. 11–23. [in Russian] 
16. Гусев Е.И., Скворцова В.И. Нейропротективная терапия ишемического инсульта. Нервные болезни. 2002; 1: 3–10. / Gusev E.I., Skvortsova V.I. Neiroprotektivnaia terapiia ishemicheskogo insul'ta. Nervnye bolezni. 2002; 1: 3–10. [in Russian]
17. Попова Т.Е. Особенности развития и коррекции гипоксии у больных с ишемическим инсультом. Дис. … канд. мед. наук. М., 2001. / Popova T.E. Osobennosti razvitiia i korrektsii gipoksii u bol'nykh s ishemicheskim insul'tom. Dis. … kand. med. nauk. M., 2001. [in Russian]
18. Бодыхов М.К., Стаховская Л.В., Салимов К.А., Чер Сун И. Оценка безопасности и эффективности препарата «Элькар» (левокарнитин) у пациентов в остром периоде ишемического инсульта в каротидной системе. РМЖ. Неврология. Психиатрия. 2011; 19 (9): 3–8. / Bodykhov M.K., Stakhovskaia L.V., Salimov K.A., Cher Sun I. Otsenka bezopasnosti i effektivnosti preparata "El'kar' (levokarnitin) u patsientov v ostrom periode ishemicheskogo insul'ta v karotidnoi sisteme. RMZh. Nevrologiia. Psikhiatriia. 2011; 19 (9): 3–8. [in Russian]
19. Ferrari R, Merli E, Cicchitelli G et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci 2004; 1033: 79–91.
20. Головкин В., Зуев А., Привалова М. и др. Когнитивные нарушения и кардиореспираторная дисфункция при дисциркуляторной энцефалопатии с кардиоцеребральным синдромом. Врач. 2018; 29 (4): 51–3. DOI: 10.29296/25877305-2018-04-09 / Golovkin V., Zuev A., Privalova M. i dr. Kognitivnye narusheniia i kardiorespiratornaia disfunktsiia pri distsirkuliatornoi entsefalopatii s kardiotserebral'nym sindromom. Vrach. 2018; 29 (4): 51–3. DOI: 10.29296/25877305-2018-04-09 [in Russian]
21. Чичановская Л.В., Бахарева О.Н., Сорокина К.Б. Исследование безопасности и эффективности L-карнитина у больных в раннем восстановительном периоде ишемического инсульта. Журн. неврологии и психиатрии им. С.С.Корсакова. 2017; 12 (2): 65–9. / Chichanovskaia L.V., Bakhareva O.N., Sorokina K.B. Issledovanie bezopasnosti i effektivnosti L-karnitina u bol'nykh v rannem vosstanovitel'nom periode ishemicheskogo insul'ta. Zhurn. nevrologii i psikhiatrii im. S.S.Korsakova. 2017; 12 (2): 65–9. [in Russian]
22. Svoboda Z, Kvĕtina J, Herink J et al. Galantamine antiacetylcholinesterase activity in rat brain influenced by L-carnitine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005; 149 (2): 335–7.
23. Nałecz K, Miecz D, Berezowski V et al. Carnitine: transport and physiological functions in the brain. Mol Aspects Med 2004; 25 (5–6): 551–67.

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1. Blinder P, Tsai PS, Kaufhold JP et al. The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nat Neurosci 2013; 16: 889–97. http://doi.org/10.1038/nn.3426
2. Gulevskaia T.S., Morgunov V.A. Patologicheskaia anatomiia narushenii mozgovogo krovoobrashcheniia pri ateroskleroze i arterial'noi gipertenzii. M.: Meditsina, 2009. [in Russian]
3. Nishimura N, Rosidi NL, Iadecola C, Schaffer CB. Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. J Cereb Blood Flow Metab 2010; 30: 1914–27. http://doi.org/10.1038/jcbfm.2010.157
4. Kampoli AM, Tousoulis D, Briasoulis A et al. Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus. Curr Pharm Des 2011; 17 (37): 4147–58.
5. McLauchlan D, Malik GA, Robertson NP. Cerebral amyloid angiopathy: subtypes, treatment and role in cognitive impairment. J Neurol 2017; 264: 2184–6. https://doi.org/10.1007/s00415-017-8608-7
6. Cooper L, Woodard T, Sigurdsson S et al. Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory. Hypertension 2016; 67: 176–82. https://doi.org/10.1161/HYPERTENSIONAHA.115.06398
7. Pase MP, Himali JJ, Mitchell GF et al. Association of aortic stiffness with cognition and brain aging in young and middle-aged adults: the Framingham third generation cohort study. Hypertension 2016; 67 (3): 513–9. https://doi.org/10.1161/HYPERTENSIONAHA.115.06610
8. Prystowsky EN, Padanilam BJ. Preserve the Brain: Primary Goal in the Therapy of Atrial Fibrillation. J Am Coll Cardiol 2013; 62 (6): 540–2. DOI: 10.1016/j.jacc.2013.04.038
9. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ 2018; 361: k1675. https://doi.org/10.1136/bmj.k1675
10. Gusev E, Skvortsova V. Brain Ischemia. New York-Boston-Dordecht-London: Kluwer Academic/Plenum Publishers, 2003.
11. Kuzin V.M. Karnitina khlorid (25 let v klinicheskoi praktike). RMZh. 2003; 11 (10): 5–9. [in Russian]
12. Suslina Z.A., Fedorova T.N., Maksimova M.Iu., Kim E.K. Antioksidantnaia aktivnost' mildronata i L-karnitina pri lechenii patsientov s tserebrovaskuliarnymi zabolevaniiami. Eksp. klin. farm. 2003; 66 (3): 32–5. [in Russian]
13. McMackin C, Widlansky M, Hamburg N et al. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich) 2007; 9 (4): 249–55.
14. Volek J, Judelson D, Silvestre R et al. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Am J Cardiol 2008; 102 (10): 1413–7.
15. Gusev E.I., Kuzin V.M., Kolesnikova T.N. i dr. Karnitin – vedushchii faktor regeneratsii nervnoi tkani. Med. informatsionnyi vestn. 1999 (fevral'): s. 11–23. [in Russian] 
16. Gusev E.I., Skvortsova V.I. Neiroprotektivnaia terapiia ishemicheskogo insul'ta. Nervnye bolezni. 2002; 1: 3–10. [in Russian]
17. Popova T.E. Osobennosti razvitiia i korrektsii gipoksii u bol'nykh s ishemicheskim insul'tom. Dis. … kand. med. nauk. M., 2001. [in Russian]
18. Bodykhov M.K., Stakhovskaia L.V., Salimov K.A., Cher Sun I. Otsenka bezopasnosti i effektivnosti preparata "El'kar' (levokarnitin) u patsientov v ostrom periode ishemicheskogo insul'ta v karotidnoi sisteme. RMZh. Nevrologiia. Psikhiatriia. 2011; 19 (9): 3–8. [in Russian]
19. Ferrari R, Merli E, Cicchitelli G et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci 2004; 1033: 79–91.
20. Golovkin V., Zuev A., Privalova M. i dr. Kognitivnye narusheniia i kardiorespiratornaia disfunktsiia pri distsirkuliatornoi entsefalopatii s kardiotserebral'nym sindromom. Vrach. 2018; 29 (4): 51–3. DOI: 10.29296/25877305-2018-04-09 [in Russian]
21. Chichanovskaia L.V., Bakhareva O.N., Sorokina K.B. Issledovanie bezopasnosti i effektivnosti L-karnitina u bol'nykh v rannem vosstanovitel'nom periode ishemicheskogo insul'ta. Zhurn. nevrologii i psikhiatrii im. S.S.Korsakova. 2017; 12 (2): 65–9. [in Russian]
22. Svoboda Z, Kvĕtina J, Herink J et al. Galantamine antiacetylcholinesterase activity in rat brain influenced by L-carnitine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005; 149 (2): 335–7.
23. Nałecz K, Miecz D, Berezowski V et al. Carnitine: transport and physiological functions in the brain. Mol Aspects Med 2004; 25 (5–6): 551–67.

А.А.Тяжельников1, З.Х.Осмаева2, П.Р.Камчатнов*3, А.В.Чугунов3

1 ГБУЗ «Городская консультативно-диагностическая поликлиника №121» Департамента здравоохранения Москвы. 117042, Россия, Москва, Южнобутовская ул., д. 87;
2 ФГБОУ ВО «Чеченский государственный университет». 364024, Россия, Грозный, ул. А.Шерипова, д. 32;
3 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1

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A.A.Tyazhelnikov1, Z.Kh.Osmayeva2, P.R.Kamchatnov3*, A.V.Chugunov3

1 City Consultative and Diagnostic Polyclinic №121 of the Department of Health of Moscow. 117042, Russian Federation, Moscow, Iuzhnobutovskaia ul., d. 87;
2 Chechen State University. 364024, Russian Federation, Grozny, ul. A.Sheripova, d. 32;
3 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*pavkam7@gmail.com