В статье рассматриваются исторические аспекты изучения валацикловира в дерматологической практике у пациентов при опоясывающем герпесе. Анализируются опубликованные данные о клинической эффективности и безопасности использования валацикловира у пациентов с опоясывающим герпесом. Авторами приводятся результаты собственных клинических наблюдений.
________________________________________________
The article deals with the historical aspects of the study of valacyclovir in dermatological practice in patients with herpes zoster. Published data on the clinical efficacy and safety of valacyclovir in patients with herpes zoster are analyzed. The authors present the results of their own clinical observations.
1. Purifoy DJ, Beauchamp LM, de Miranda P et al. Review of research leading to new anti-herpesvirus agents in clinical development: valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus. J Med Virol 1993; Suppl. 1: 139–45.
2. Weller S, Blum MR, Doucette M et al. Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers. Clin Pharmacol Ther 1993; 54 (6): 595–605.
3. Jacobson MA. Valaciclovir (BW256U87): the L-valyl ester of acyclovir. J Med Virol 1993; (Suppl. 1): 150–3.
4. Darby G. Acyclovir – and beyond. J Int Med Res 1994; 22 (Suppl. 1): 33A–42A.
5. Gnann JW. New antivirals with activity against varicella-zoster virus. Ann Neurol 1994; 35 (Suppl.): S69–72.
6. Perry CM, Faulds D. Valaciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections. Drugs 1996; 52 (5): 754–72.
7. Shinkai I, Ohta Y. New drugs – reports of new drugs recently approved by the FDA. Valacyclovir. Bioorg Med Chem 1996; 4 (1): 1–2.
8. Beutner KR. Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy. Antiviral Res 1995; 28 (4): 281–90.
9. Reusser P. Herpesvirus resistance to antiviral drugs: a review of the mechanisms, clinical importance and therapeutic options. J Hosp Infect 1996; 33 (4): 235–48.
10. Acosta EP, Fletcher CV. Valacyclovir. Ann Pharmacother 1997; 31 (2): 185–91.
11. Piérard GE, Nikkels AF. Drug of the month. Valaciclovir (Zelitrex). Rev Med Liege 1997; 52 (8): 553–5.
12. Koshy E, Mengting L, Kumar H, Jianbo W. Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian J Dermatol Venereol Leprol 2018; 84 (3): 251–62.
13. Harpaz R, Ortega-Sanchez IR, Seward JF. Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2008; 57(RR-5): 1–30.
14. Федеральные клинические рекомендации. Дерматовенерология 2015. Болезни кожи. Инфекции, передаваемые половым путем. 5-е изд., перераб. и доп. М.: Деловой экспресс, 2016. / Federalnye klinicheskie rekomendacii. Dermatovenerologiya 2015. Bolezni kozhi. Infekcii, peredavaemye polovym putem. 5-e izd., pererab. i dop. M.: Delovoj ekspress, 2016. [in Russian]
15. Bruxelle J, Pinchinat S. Effectiveness of antiviral treatment on acute phase of herpes zoster and development of post herpetic neuralgia: review of international publications. Med Mal Infect 2012; 42 (2): 53–8.
16. Fukushima T, Sato T, Nakamura T et al. Daily 500 mg valacyclovir is effective for prevention of Varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib. Anticancer Res 2012; 32 (12): 5437–40.
17. Wittek M, Doerr HW, Allwinn R. Varicella and herpes zoster. Part 2: therapy and prevention. Med Klin (Munich) 2010; 105 (6): 399–403.
18. Kimberlin DW, Jacobs RF, Weller S et al. Pharmacokinetics and safety of extemporaneously compounded valacyclovir oral suspension in pediatric patients from 1 month through 11 years of age. Clin Infect Dis 2010; 50 (2): 221–8.
19. Ono F, Yasumoto S, Furumura M et al. Comparison between famciclovir and valacyclovir for acute pain in adult Japanese immunocompetent patients with herpes zoster. J Dermatol 2012; 39 (11): 902–8.
20. McDonald EM, de Kock J, Ram FS. Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials. Antivir Ther 2012; 17 (2): 255–64.
21. Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010; 304 (8): 859–66.
22. Pavan-Langston D. Herpes zoster antivirals and pain management. Ophthalmology 2008; 115 (Suppl. 2): S13–20.
23. Smith DE, Gold J. Famciclovir or valaciclovir in the management of herpes simplex and varicella zoster infections: an attitudinal survey of clinician perceptions of differential activity. Sex Health 2007; 4 (2): 141–2.
24. Jubelt B. Valacyclovir and famciclovir therapy in herpes zoster. Curr Neurol Neurosci Rep 2002; 2 (6): 477–8.
25. Dworkin RH, Johnson RW, Breuer J et al. Recommendations for the management of herpes zoster. Clin Infect Dis 2007; 44 (Suppl. 1): S1–26.
Авторы
М.В.Жучков*1,2, Е.Е.Большакова1, Д.Б.Сонин1, С.А.Родионова1
1. ГБУ РО «Областной клинический кожно-венерологический диспансер». 390046, Россия, Рязань, ул. Спортивная, д. 9;
2. ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П.Павлова» Минздрава России.
390026, Россия, Рязань, ул. Высоковольтная, д. 9
*misha.juchkov@gmail.com
________________________________________________
M.V.Zhuchkov*1,2, E.E.Bolshakova1, D.B.Sonin1, S.A.Rodionova1
1. Ryazan State Regional Dermato-Venerological Clinic.
390046, Russian Federation, Ryazan, ul. Sportivnaia, d. 9;
2. I.P.Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation. 390026, Russian Federation, Riazan, ul. Vysokovol'tnaia, d. 9
*misha.juchkov@gmail.com