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Актуальная терапия инфекционных заболеваний кожи и подкожно-жировой клетчатки
Дворянкова Е.В. Актуальная терапия инфекционных заболеваний кожи и подкожно-жировой клетчатки. Гастроэнтерология. Хирургия. Интенсивная терапия. Consilium Medicum. 2018; 2: 60–64. DOI: 10.26442/26583739.2018.2.180128
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Dvoriankova E.V. Relevan treatment of infectious diseases of the skin and subcutaneous fat. Gastroenterology. Surgery. Intensive care. Consilium Medicum. 2018; 2: 60–64.
DOI: 10.26442/26583739.2018.2.180128
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Аннотация
Инфекционные заболевания кожи и подкожно-жировой клетчатки представляют собой большой кластер достаточно распространенных типов инфекции, включая абсцессы, целлюлит, вторично инфицированные раны, которые требуют немедленного эффективного и своевременного антибактериального лечения. Однако инфекционные заболевания, вызванные метициллин-резистентными штаммами микроорганизмов, а также наличие факторов риска лечения либо полный отказ от него больных делают подбор антибактериальной терапии весьма сложной задачей. Применение комбинированных топических антибактериальных лекарственных средств, содержащих ионы серебра, позволяет проводить адекватную терапию инфекционных заболеваний кожи и предотвращать развитие метициллин-резистентности.
Ключевые слова: инфекция кожи, золотистый стафилококк, метициллин-резистентность, сульфатиазол серебра.
Ключевые слова: инфекция кожи, золотистый стафилококк, метициллин-резистентность, сульфатиазол серебра.
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Infectious diseases of the skin and subcutaneous fat represent a large cluster of common types of infection. They include abscesses, cellulitis, secondarily infected wounds which require immediate effective and timely antibacterial treatment. However, selection of antibiotic therapy can be a very difficult task if an infection disease is caused by methicillin-resistant strains of microorganisms or there are treatment risk factors or if a patient refuses treatment. The use of combined topical silver – containing antibacterial drugs provides an adequate management of infectious skin diseases and prevention of methicillin-resistance development.
Key words: skin infection, Staphylococcus aureus, methicillin-resistance, silver sulfathiazole.
Полный текст
Список литературы
1. Cheung AL, Wolz C, Yeaman MR, Bayer AS. Insertional inactivation of a chromosomal locus that modulates expression of potential virulence determinants in Staphylococcus aureus. J Bacteriol 1995; 177: 3220–6.
2. Patti JM, Allen BL, McGavin MJ, Hook M. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol 1994; 48: 585–617.
3. Garau J, Ostermann H, Medina J et al. Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010–2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study. Clin Microbiol Infect 2013; 19: E377–E385.
4. Boucher HW, Talbot GH, Bradley JS et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 1–12.
5. Jokinen E, Laine J, Huttunen R et al. Trends in incidence and resistance patterns of Staphylococcus aureus bacteremia. Infect Dis (Lond) 2018; 50 (1): 52–8.
6. Pichereau S, Rose WE. Invasive community-associated MRSA infections: epidemiology and antimicrobial management. Expert Opin Pharmacother 2010; 11 (18): 3009–25.
7. Lin MY, Hayden MK, Lyles RD et al. Prevention Epicenters Program, Centers for Disease Control and Prevention. Regional Epidemiology of Methicillin-Resistant Staphylococcus aureus Among Adult Intensive Care Unit Patients Following State-Mandated Active Surveillance. Clin Infect Dis 2018; 66 (10): 1535–9.
8. Rosen J, Landriscina A, Kutner A et al. Silver sulfadiazine retards wound healing in mice via alterations in cytokine expression. J Invest Dermatol 2015; 135 (5): 1459–62.
9. Jodar KS, Balcão VM, Chaud MV et al. Development and characterization of a hydrogel containing silver sulfadiazine for antimicrobial topical applications. J Pharm Sci 2015;
104 (7): 2241–54.
10. Самцов А.В., Теличко И.Н., Стаценко А.В., Хайрутдинов В.Р. Применение наружных средств, содержащих соединения серебра, в терапии больных пиодермиями. Вестн. дерматологии и венерологии. 2014; 1: 7580. / Samtsov A.V., Telichko I.N., Statsenko A.V., Khairutdinov V.R. Primenenie naruzhnykh sredstv, soderzhashchikh soedineniia serebra, v terapii bol'nykh piodermiiami. Vestn. dermatologii i venerologii. 2014; 1: 7580. [in Russian]
2. Patti JM, Allen BL, McGavin MJ, Hook M. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol 1994; 48: 585–617.
3. Garau J, Ostermann H, Medina J et al. Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010–2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study. Clin Microbiol Infect 2013; 19: E377–E385.
4. Boucher HW, Talbot GH, Bradley JS et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 1–12.
5. Jokinen E, Laine J, Huttunen R et al. Trends in incidence and resistance patterns of Staphylococcus aureus bacteremia. Infect Dis (Lond) 2018; 50 (1): 52–8.
6. Pichereau S, Rose WE. Invasive community-associated MRSA infections: epidemiology and antimicrobial management. Expert Opin Pharmacother 2010; 11 (18): 3009–25.
7. Lin MY, Hayden MK, Lyles RD et al. Prevention Epicenters Program, Centers for Disease Control and Prevention. Regional Epidemiology of Methicillin-Resistant Staphylococcus aureus Among Adult Intensive Care Unit Patients Following State-Mandated Active Surveillance. Clin Infect Dis 2018; 66 (10): 1535–9.
8. Rosen J, Landriscina A, Kutner A et al. Silver sulfadiazine retards wound healing in mice via alterations in cytokine expression. J Invest Dermatol 2015; 135 (5): 1459–62.
9. Jodar KS, Balcão VM, Chaud MV et al. Development and characterization of a hydrogel containing silver sulfadiazine for antimicrobial topical applications. J Pharm Sci 2015;
104 (7): 2241–54.
10. Самцов А.В., Теличко И.Н., Стаценко А.В., Хайрутдинов В.Р. Применение наружных средств, содержащих соединения серебра, в терапии больных пиодермиями. Вестн. дерматологии и венерологии. 2014; 1: 7580. / Samtsov A.V., Telichko I.N., Statsenko A.V., Khairutdinov V.R. Primenenie naruzhnykh sredstv, soderzhashchikh soedineniia serebra, v terapii bol'nykh piodermiiami. Vestn. dermatologii i venerologii. 2014; 1: 7580. [in Russian]
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1. Cheung AL, Wolz C, Yeaman MR, Bayer AS. Insertional inactivation of a chromosomal locus that modulates expression of potential virulence determinants in Staphylococcus aureus. J Bacteriol 1995; 177: 3220–6.
2. Patti JM, Allen BL, McGavin MJ, Hook M. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol 1994; 48: 585–617.
3. Garau J, Ostermann H, Medina J et al. Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010–2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study. Clin Microbiol Infect 2013; 19: E377–E385.
4. Boucher HW, Talbot GH, Bradley JS et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 1–12.
5. Jokinen E, Laine J, Huttunen R et al. Trends in incidence and resistance patterns of Staphylococcus aureus bacteremia. Infect Dis (Lond) 2018; 50 (1): 52–8.
6. Pichereau S, Rose WE. Invasive community-associated MRSA infections: epidemiology and antimicrobial management. Expert Opin Pharmacother 2010; 11 (18): 3009–25.
7. Lin MY, Hayden MK, Lyles RD et al. Prevention Epicenters Program, Centers for Disease Control and Prevention. Regional Epidemiology of Methicillin-Resistant Staphylococcus aureus Among Adult Intensive Care Unit Patients Following State-Mandated Active Surveillance. Clin Infect Dis 2018; 66 (10): 1535–9.
8. Rosen J, Landriscina A, Kutner A et al. Silver sulfadiazine retards wound healing in mice via alterations in cytokine expression. J Invest Dermatol 2015; 135 (5): 1459–62.
9. Jodar KS, Balcão VM, Chaud MV et al. Development and characterization of a hydrogel containing silver sulfadiazine for antimicrobial topical applications. J Pharm Sci 2015;
104 (7): 2241–54.
10. Samtsov A.V., Telichko I.N., Statsenko A.V., Khairutdinov V.R. Primenenie naruzhnykh sredstv, soderzhashchikh soedineniia serebra, v terapii bol'nykh piodermiiami. Vestn. dermatologii i venerologii. 2014; 1: 7580. [in Russian]
Авторы
Е.В.Дворянкова*
ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН. 119991, Россия, Москва, Ленинский пр-т, д. 38а, корп. 1
*dvoriankova@mail.ru
ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН. 119991, Россия, Москва, Ленинский пр-т, д. 38а, корп. 1
*dvoriankova@mail.ru
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E.V.Dvoriankova*
Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences. 119991, Russian Federation, Moscow, Leninskiy pr-t, d. 38a, korp. 1
*dvoriankova@mail.ru
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