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Возможности регенеративной медицины в оториноларингологии (обзор литературы)
Возможности регенеративной медицины в оториноларингологии (обзор литературы)
Свистушкин В.М., Старостина С.В., Свистушкин М.В. и др. Возможности регенеративной медицины в оториноларингологии (обзор литературы). Consilium Medicum. 2019; 21 (11): 15–19. DOI: 10.26442/20751753.2019.11.190641
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Аннотация
За последние 30 лет тканевая инженерия из теоретической области научного интереса превратилась в широкое экспериментальное поле для деятельности. Кожа, костная ткань, хрящи, сосуды – это лишь некоторые примеры органов и тканей, которые возможно создать в лаборатории благодаря регенеративной медицине. На данный момент сложно найти область медицины, где бы разработки тканевой инженерии и клеточной терапии не были востребованы; оториноларингология не стала исключением. Глобально для исследователей в регенеративной медицине существует 3 области интереса: изучение клеток, возможность использования нативных и синтезируемых биокаркасов (скаффолдов), применение различных рекомбинантных факторов роста и других клеточных мишеней. Возможности регенеративной медицины в области оториноларингологии крайне широки, что объясняется большой вариативностью ЛОР-патологий. Отиатрия, ринология, ларингология – в каждой из областей сего-дня проводятся десятки перспективных доклинических и клинических исследований, результаты которых уже в ближайшем будущем существенно расширят применение малоинвазивных методов лечения. Одними из немногих факторов, сдерживающих еще более стремительное развитие данной области, остаются несовершенство нормативно-правового регулирования и несоответствие качества доклинических исследований требованиям этических комитетов. Многие открытые вопросы требуют решений: перспективность продолжения исследований в направлении развития регенеративных технологий очевидна. Восстановление тканей и их функций в оториноларингологии методами регенеративной медицины позволит решить задачи, которые раньше казались невыполнимыми.
Ключевые слова: оториноларингология, регенеративная медицина, стволовые клетки, тканевая инженерия.
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During last 30 years the tissue engineering fr om theoretical area of scientific interest turned into the wide practical field for experiment. Skin, bone tissue, cartilage, blood vessels are just some examples of organs and tissues that, thanks to regenerative medicine, can be created in the laboratory. At the moment it is difficult to find a field of medicine wh ere the development of tissue engineering and cell therapy would not be in demand. Otolaryngology is no exception. Globally for researchers in regenerative medicine, there are 3 areas of interest: the study of cells, the possibility of using native and synthesized bio-scaffolds, the use of various recombinant growth factors and other cellular targets. The possibilities of regenerative medicine in the field of otolaryngology are extremely wide, which is explained by the large variability of diseases. Otiatry, rhinology, laryngology – dozens of promising preclinical and clinical studies are being conducted in each of the areas today, the results of which in the near future will significantly expand the use of minimally invasive treatment methods. One of the few factors hol-ding back even more rapid development of this area remains the imperfection of the regulatory framework and the discrepancy between the quality of preclinical studies and the requirements of ethical committees. Many open questions require immediate solutions, because the promise of continuing research towards the development of regenerative technologies is obvious. The restoration of tissues and their functions in otorhinolaryngology with the methods of regenerative me-dicine will make it possible to solve problems that previously seemed impossible.
Key words: otorhinolaryngology, regenerative medicine, stem cells, tissue engineering.
Полный текст
Список литературы
1. Lokmic Z, Mitchell GM. Engineering the Microcirculation. Tissue Eng Part B: Reviews 2008; 14 (1): 87–103.
2. Caplan AI, Correa D. Perspective The MSC: An Injury Drugstore. Cell Stem Cell 2011; 9 (1): 11–5.
3. Vacanti CA. The history of tissue engineering. J Cell Mol Med 2006; 10 (3): 569–76.
4. Sándor GK, Numminen J, Wolff J, Thesleff T et al. Adipose Stem Cells Used to Reconstruct 13 Cases With Cranio-Maxillofacial Hard-Tissue Defects. Tissue Eng Regenerative Med 2014; 530–40.
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7. King SN, Hanson SE, Hematti P, Thibeault SL. Current applications of mesenchymal stem cells for tissue replacement in otolaryngology. Head Neck Surg 2012; 1 (3): 225–38.
8. Ito J. Regenerative Medicine in Otolaryngology. Kyoto. Springer Japan 2015.
9. Scheller EL, Krebsbach PH, Kohn DH. Tissue Engineering: state of the art in oral rehabilitation. J Oral Rehab 2009; 36 (5): 368–89.
10. Cedervall J, Ährlund-richter L, Svensson B et al. Injection of Embryonic Stem Cells Into Scarred Rabbit Vocal Folds Enhances Healing and Improves Viscoelasticity: Short-Term Results. Laryngoscope 2007; 117: 2075–81.
11. Hipp J, Atala A. Sources of Stem Cells for Regenerative Medicine. Stem Cell Rev 2008; 4 (1): 3–11.
12. Vizoso FJ, Eiro N, Cid S et al. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci 2017; 18: 1852.
13. Imaizumi M, Li-jessen NYK et al. Retention of Human-Induced Pluripotent Stem Cells (hiPS ) With Injectable HA Hydrogels for Vocal Fold Engineering. Ann Otol Rhinol Laryngol 2017; 11: 1–11.
14. Takemoto S, Morimoto N et al. Preparation of Collagen/Gelatin Sponge Scaffold for Sustained Release of bFGF. Tissue Eng Part A 2008; 14 (10): 1629–38.
15. Metsger DS, Driskell TD, Paulsrud JR. Tricalcium Phosphate Ceramic – A Resorbable Bone Implant: Review and Current Status. J Am Dental Assoc 1982; 105 (6): 1035–8.
16. Macri L, Silverstein D, Clark RAF. Growth factor binding to the pericellular matrix and its importance in tissue engineering. Advanced Drug Delivery Rev 2007; 59: 1366–81.
17. Wormald JCR, Fishman JM, Juniat S et al. Regenerative medicine in otorhinolaryngology. J Laryngol Otol 2015; 129 (8): 732–9.
18. Kanemaru S, Umeda H, Kanai R et al. Regenerative Treatment for Soft Tissue Defects of the External Auditory Meatus. Otol Neurol 2014; 35 (3): 442–8.
19. Kanemaru S, Umeda H, Kitani Y et al. Regenerative Treatment for Tympanic Membrane Perforation. Otol Neurol 2011; 32 (8): 1218–23.
20. Hakuba N, Tabata Y, Hato N et al. Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration. Otol Neurotol 2014; 35 (3): 540–4.
21. Lou Z, Huang P, Yang J et al. Direct application of bFGF without edge trimming on human subacute tympanic membrane perforation. Am J Otolaryngol 2016; 37 (2): 156–61.
22. Kanemaru S, Umeda H, Yamashita M et al. Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells. Laryngoscope 2012; 123 (2): 472–6. DOI: 10.1002/lary.23626
23. Perny M, Ting C, Kleinlogel S, Senn P. Generation of Otic Sensory Neurons from Mouse Embryonic Stem Cells in 3D Culture. Front Cell Neurosci 2017; 11: 1–12.
24. Fulco I, Miot S, Haug MD et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet 2014; 6736 (14): 1–10.
25. Lee CH, Jeon S, Seo BS, Mo J. Transplantation of Neural Stem Cells in Anosmic Mice. Clin Exper Otorhinolaryngol 2010; 3 (2): 84–90.
26. Xu X, Li L, Wang C et al. The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue. Cell Biosci 2015; 5 (1).
27. Businco LD, Mario AD, Tombolini M et al. Functional Reconstruction of Turbinates with Growth Factors and Adipose Tissue in the Treatment of Empty Nose Syndrome. J J Bone Stem Res 2015; 1 (2).
28. Lerner MZ, Matsushita T, Lankford KL et al. Intravenous Mesenchymal Stem Cell Therapy After Recurrent Laryngeal Nerve Injury: A Preliminary Study. Laryngoscope 2014; 124 (11): 2555–60.
29. Gray FL, Turner CG, Ahmed A et al. Prenatal tracheal reconstruction with a hybrid amniotic mesenchymal stem cells-engineered construct derived from decellularized airway. J Pediatr Surg 2012; 47 (6): 1072–9.
30. Go T, Jungebluth P, Baiguero S et al. Both epithelial cells and mesenchymal stem cell – derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg 2010; 139 (2): 437–43.
31. Svensson B, Nagubothu RS, Cedervall J et al. Injection of Human Mesenchymal Stem Cells Improves Healing of Scarred Vocal Folds: Analysis Using a Xenograft Model. Laryngoscope 2010; 7: 1370–5.
32. Свистушкин В.М., Старостина С.В., Люндуп А.В. и др. Возможности клеточных технологий в лечении рубцовых поражений голосовых складок. Вестн. РАМН. 2016; 71 (3): 190–9.
[Svistushkin V.M., Starostina S.V., Liundup A.V. et al. Vozmozhnosti kletochnykh tekhnologii v lechenii rubtsovykh porazhenii golosovykh skladok. Vestn. RAMN. 2016; 71 (3): 190–9 (in Russian).]
33. De Bonnecaze G, Chaput B, Woisard V et al. Adipose Stromal Cells Improve Healing of Vocal Fold Scar: Morphological and Functional Evidences. Laryngoscope 2016: 1–8.
34. Friedrich G, Dikkers FG, Arens C et al. Vocal fold scars: current concepts and future directions. Consensus report of the phonosurgery committee of the European laryngological society. Eur Archiv Oto-Rhino-Laryngol 2013; 270 (9): 2491–507.
35. Wingstrand VL, Grønhøj Larsen C, Jensen DH et al. Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring: A Systematic Review of Preclinical Studies. PLOS One 2016; 11 (9): e0162349. DOI: 10.1371/journal.pone.0162349
36. Young-Mo K, Tacghee Yi, Jeong-Seok C et al. Bone Marrow-Derived Clonal Mesenchymal Stem Cells as a Source of Cell Therapy for Promoting Vocal Fold Wound Healing. Ann Otol Rhinol Laryngol 2013; 122 (Issue 2): 121–30.
37. Karolinska University Hospital.Sweden. Pilot Study of Stem Cell Treatment of Patients With Vocal Fold Scarring. NCT01981330 [Internet]. clinicaltrial.com 2017. September.
38. Assistance Publique Hopitaux De Marseille. France. Innovative Treatment for Scarred Vocal Cords by Local Injection of Autologous Stromal Vascular Fraction. NCT02622464 [Internet]. clinicaltrials.com 2016. April.
39. Мельникова Е.В., Горяев А.А., Савкина М.В. и др. Международный опыт нормативно-правового регулирования препаратов, содержащих жизнеспособные клетки человека. БИОпрепараты. Профилактика, диагностика, лечение. 2018; 18 (3): 150–60.
[Mel'nikova E.V., Goriaev A.A., Savkina M.V. et al. Mezhdunarodnyi opyt normativno-pravovogo regulirovaniia preparatov, soderzhashchikh zhiznesposobnye kletki cheloveka. BIOpreparaty. Profilaktika, diagnostika, lechenie. 2018; 18 (3): 150–60 (in Russian).]
3.Vacanti CA. The history of tissue engineering. J Cell Mol Med 2006; 10 (3): 569–76.
4.Sándor GK, Numminen J, Wolff J, Thesleff T et al. Adipose Stem Cells Used to Reconstruct 13 Cases With Cranio-Maxillofacial Hard-Tissue Defects. Tissue Eng Regenerative Med 2014; 530–40.
5.Gianluca Sampogna, Salman Yousuf Guraya, Antonello Forgione. Regenerative medicine: Hi-storical roots and potential strategies in modern medicine. J Microscopy Ultrastructure 2015; 3. Issue 3: 101–7.
6.Owaki T, Shimizu T, Yamato M, Okano T. Cell sheet engineering for regenerative medicine: Cur-rent challenges and strategies. Biotech J 2014; 9 (3): 904–14.
7.King SN, Hanson SE, Hematti P, Thibeault SL. Current applications of mesenchymal stem cells for tissue replacement in otolaryngology. Head Neck Surg 2012; 1 (3): 225–38.
8.Ito J. Regenerative Medicine in Otolaryngology. Kyoto. Springer Japan 2015.
9.Scheller EL, Krebsbach PH, Kohn DH. Tissue Engineering: state of the art in oral rehabilitation. J Oral Rehab 2009; 36 (5): 368–89.
10.Cedervall J, Ährlund-richter L, Svensson B et al. Injection of Embryonic Stem Cells Into Scarred Rabbit Vocal Folds Enhances Healing and Improves Viscoelasticity: Short-Term Results. Laryn-goscope 2007; 117: 2075–81.
29. Gray FL, Turner CG, Ahmed A et al. Prenatal tracheal reconstruction with a hybrid amniotic me-senchymal stem cells-engineered construct derived from decellularized airway. J Pediatr Surg 2012; 47 (6): 1072–9.
30. Go T, Jungebluth P, Baiguero S et al. Both epithelial cells and mesenchymal stem cell – derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg 2010; 139 (2): 437–43.
31.Svensson B, Nagubothu RS, Cedervall J et al. Injection of Human Mesenchymal Stem Cells Im-proves Healing of Scarred Vocal Folds: Analysis Using a Xenograft Model. Laryngoscope 2010; 7: 1370–5.
2. Caplan AI, Correa D. Perspective The MSC: An Injury Drugstore. Cell Stem Cell 2011; 9 (1): 11–5.
3. Vacanti CA. The history of tissue engineering. J Cell Mol Med 2006; 10 (3): 569–76.
4. Sándor GK, Numminen J, Wolff J, Thesleff T et al. Adipose Stem Cells Used to Reconstruct 13 Cases With Cranio-Maxillofacial Hard-Tissue Defects. Tissue Eng Regenerative Med 2014; 530–40.
5. Gianluca Sampogna, Salman Yousuf Guraya, Antonello Forgione. Regenerative medicine: Historical roots and potential strategies in modern medicine. J Microscopy Ultrastructure 2015; 3. Issue 3: 101–7.
6. Owaki T, Shimizu T, Yamato M, Okano T. Cell sheet engineering for regenerative medicine: Current challenges and strategies. Biotech J 2014; 9 (3): 904–14.
7. King SN, Hanson SE, Hematti P, Thibeault SL. Current applications of mesenchymal stem cells for tissue replacement in otolaryngology. Head Neck Surg 2012; 1 (3): 225–38.
8. Ito J. Regenerative Medicine in Otolaryngology. Kyoto. Springer Japan 2015.
9. Scheller EL, Krebsbach PH, Kohn DH. Tissue Engineering: state of the art in oral rehabilitation. J Oral Rehab 2009; 36 (5): 368–89.
10. Cedervall J, Ährlund-richter L, Svensson B et al. Injection of Embryonic Stem Cells Into Scarred Rabbit Vocal Folds Enhances Healing and Improves Viscoelasticity: Short-Term Results. Laryngoscope 2007; 117: 2075–81.
11. Hipp J, Atala A. Sources of Stem Cells for Regenerative Medicine. Stem Cell Rev 2008; 4 (1): 3–11.
12. Vizoso FJ, Eiro N, Cid S et al. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci 2017; 18: 1852.
13. Imaizumi M, Li-jessen NYK et al. Retention of Human-Induced Pluripotent Stem Cells (hiPS ) With Injectable HA Hydrogels for Vocal Fold Engineering. Ann Otol Rhinol Laryngol 2017; 11: 1–11.
14. Takemoto S, Morimoto N et al. Preparation of Collagen/Gelatin Sponge Scaffold for Sustained Release of bFGF. Tissue Eng Part A 2008; 14 (10): 1629–38.
15. Metsger DS, Driskell TD, Paulsrud JR. Tricalcium Phosphate Ceramic – A Resorbable Bone Implant: Review and Current Status. J Am Dental Assoc 1982; 105 (6): 1035–8.
16. Macri L, Silverstein D, Clark RAF. Growth factor binding to the pericellular matrix and its importance in tissue engineering. Advanced Drug Delivery Rev 2007; 59: 1366–81.
17. Wormald JCR, Fishman JM, Juniat S et al. Regenerative medicine in otorhinolaryngology. J Laryngol Otol 2015; 129 (8): 732–9.
18. Kanemaru S, Umeda H, Kanai R et al. Regenerative Treatment for Soft Tissue Defects of the External Auditory Meatus. Otol Neurol 2014; 35 (3): 442–8.
19. Kanemaru S, Umeda H, Kitani Y et al. Regenerative Treatment for Tympanic Membrane Perforation. Otol Neurol 2011; 32 (8): 1218–23.
20. Hakuba N, Tabata Y, Hato N et al. Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration. Otol Neurotol 2014; 35 (3): 540–4.
21. Lou Z, Huang P, Yang J et al. Direct application of bFGF without edge trimming on human subacute tympanic membrane perforation. Am J Otolaryngol 2016; 37 (2): 156–61.
22. Kanemaru S, Umeda H, Yamashita M et al. Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells. Laryngoscope 2012; 123 (2): 472–6. DOI: 10.1002/lary.23626
23. Perny M, Ting C, Kleinlogel S, Senn P. Generation of Otic Sensory Neurons from Mouse Embryonic Stem Cells in 3D Culture. Front Cell Neurosci 2017; 11: 1–12.
24. Fulco I, Miot S, Haug MD et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet 2014; 6736 (14): 1–10.
25. Lee CH, Jeon S, Seo BS, Mo J. Transplantation of Neural Stem Cells in Anosmic Mice. Clin Exper Otorhinolaryngol 2010; 3 (2): 84–90.
26. Xu X, Li L, Wang C et al. The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue. Cell Biosci 2015; 5 (1).
27. Businco LD, Mario AD, Tombolini M et al. Functional Reconstruction of Turbinates with Growth Factors and Adipose Tissue in the Treatment of Empty Nose Syndrome. J J Bone Stem Res 2015; 1 (2).
28. Lerner MZ, Matsushita T, Lankford KL et al. Intravenous Mesenchymal Stem Cell Therapy After Recurrent Laryngeal Nerve Injury: A Preliminary Study. Laryngoscope 2014; 124 (11): 2555–60.
29. Gray FL, Turner CG, Ahmed A et al. Prenatal tracheal reconstruction with a hybrid amniotic mesenchymal stem cells-engineered construct derived from decellularized airway. J Pediatr Surg 2012; 47 (6): 1072–9.
30. Go T, Jungebluth P, Baiguero S et al. Both epithelial cells and mesenchymal stem cell – derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg 2010; 139 (2): 437–43.
31. Svensson B, Nagubothu RS, Cedervall J et al. Injection of Human Mesenchymal Stem Cells Improves Healing of Scarred Vocal Folds: Analysis Using a Xenograft Model. Laryngoscope 2010; 7: 1370–5.
32. Свистушкин В.М., Старостина С.В., Люндуп А.В. и др. Возможности клеточных технологий в лечении рубцовых поражений голосовых складок. Вестн. РАМН. 2016; 71 (3): 190–9.
[Svistushkin V.M., Starostina S.V., Liundup A.V. et al. Vozmozhnosti kletochnykh tekhnologii v lechenii rubtsovykh porazhenii golosovykh skladok. Vestn. RAMN. 2016; 71 (3): 190–9 (in Russian).]
33. De Bonnecaze G, Chaput B, Woisard V et al. Adipose Stromal Cells Improve Healing of Vocal Fold Scar: Morphological and Functional Evidences. Laryngoscope 2016: 1–8.
34. Friedrich G, Dikkers FG, Arens C et al. Vocal fold scars: current concepts and future directions. Consensus report of the phonosurgery committee of the European laryngological society. Eur Archiv Oto-Rhino-Laryngol 2013; 270 (9): 2491–507.
35. Wingstrand VL, Grønhøj Larsen C, Jensen DH et al. Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring: A Systematic Review of Preclinical Studies. PLOS One 2016; 11 (9): e0162349. DOI: 10.1371/journal.pone.0162349
36. Young-Mo K, Tacghee Yi, Jeong-Seok C et al. Bone Marrow-Derived Clonal Mesenchymal Stem Cells as a Source of Cell Therapy for Promoting Vocal Fold Wound Healing. Ann Otol Rhinol Laryngol 2013; 122 (Issue 2): 121–30.
37. Karolinska University Hospital.Sweden. Pilot Study of Stem Cell Treatment of Patients With Vocal Fold Scarring. NCT01981330 [Internet]. clinicaltrial.com 2017. September.
38. Assistance Publique Hopitaux De Marseille. France. Innovative Treatment for Scarred Vocal Cords by Local Injection of Autologous Stromal Vascular Fraction. NCT02622464 [Internet]. clinicaltrials.com 2016. April.
39. Мельникова Е.В., Горяев А.А., Савкина М.В. и др. Международный опыт нормативно-правового регулирования препаратов, содержащих жизнеспособные клетки человека. БИОпрепараты. Профилактика, диагностика, лечение. 2018; 18 (3): 150–60.
[Mel'nikova E.V., Goriaev A.A., Savkina M.V. et al. Mezhdunarodnyi opyt normativno-pravovogo regulirovaniia preparatov, soderzhashchikh zhiznesposobnye kletki cheloveka. BIOpreparaty. Profilaktika, diagnostika, lechenie. 2018; 18 (3): 150–60 (in Russian).]
________________________________________________
1.Lokmic Z, Mitchell GM. Engineering the Microcirculation. Tissue Eng Part B: Reviews 2008; 14 (1): 87–103.
2.Caplan AI, Correa D. Perspective The MSC: An Injury Drugstore. Cell Stem Cell 2011; 9 (1): 11–5.3.Vacanti CA. The history of tissue engineering. J Cell Mol Med 2006; 10 (3): 569–76.
4.Sándor GK, Numminen J, Wolff J, Thesleff T et al. Adipose Stem Cells Used to Reconstruct 13 Cases With Cranio-Maxillofacial Hard-Tissue Defects. Tissue Eng Regenerative Med 2014; 530–40.
5.Gianluca Sampogna, Salman Yousuf Guraya, Antonello Forgione. Regenerative medicine: Hi-storical roots and potential strategies in modern medicine. J Microscopy Ultrastructure 2015; 3. Issue 3: 101–7.
6.Owaki T, Shimizu T, Yamato M, Okano T. Cell sheet engineering for regenerative medicine: Cur-rent challenges and strategies. Biotech J 2014; 9 (3): 904–14.
7.King SN, Hanson SE, Hematti P, Thibeault SL. Current applications of mesenchymal stem cells for tissue replacement in otolaryngology. Head Neck Surg 2012; 1 (3): 225–38.
8.Ito J. Regenerative Medicine in Otolaryngology. Kyoto. Springer Japan 2015.
9.Scheller EL, Krebsbach PH, Kohn DH. Tissue Engineering: state of the art in oral rehabilitation. J Oral Rehab 2009; 36 (5): 368–89.
10.Cedervall J, Ährlund-richter L, Svensson B et al. Injection of Embryonic Stem Cells Into Scarred Rabbit Vocal Folds Enhances Healing and Improves Viscoelasticity: Short-Term Results. Laryn-goscope 2007; 117: 2075–81.
11.Hipp J, Atala A. Sources of Stem Cells for Regenerative Medicine. Stem Cell Rev 2008; 4 (1): 3–11.
12.Vizoso FJ, Eiro N, Cid S et al. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci 2017; 18: 1852.
13.Imaizumi M, Li-jessen NYK et al. Retention of Human-Induced Pluripotent Stem Cells (hiPS ) With Injectable HA Hydrogels for Vocal Fold Engineering. Ann Otol Rhinol Laryngol 2017; 11: 1–11.
14.Takemoto S, Morimoto N et al. Preparation of Collagen/Gelatin Sponge Scaffold for Sustained Release of bFGF. Tissue Eng Part A 2008; 14 (10): 1629–38.
15.Metsger DS, Driskell TD, Paulsrud JR. Tricalcium Phosphate Ceramic – A Resorbable Bone Im-plant: Review and Current Status. J Am Dental Assoc 1982; 105 (6): 1035–8.
16.Macri L, Silverstein D, Clark RAF. Growth factor binding to the pericellular matrix and its impor-tance in tissue engineering. Advanced Drug Delivery Rev 2007; 59: 1366–81.
17.Wormald JCR, Fishman JM, Juniat S et al. Regenerative medicine in otorhinolaryngology. J La-ryngol Otol 2015; 129 (8): 732–9.
18.Kanemaru S, Umeda H, Kanai R et al. Regenerative Treatment for Soft Tissue Defects of the External Auditory Meatus. Otol Neurol 2014; 35 (3): 442–8.
19.Kanemaru S, Umeda H, Kitani Y et al. Regenerative Treatment for Tympanic Membrane Perfora-tion. Otol Neurol 2011; 32 (8): 1218–23.
20.Hakuba N, Tabata Y, Hato N et al. Gelatin hydrogel with basic fibroblast growth factor for tympa-nic membrane regeneration. Otol Neurotol 2014; 35 (3): 540–4.
21.Lou Z, Huang P, Yang J et al. Direct application of bFGF without edge trimming on human sub-acute tympanic membrane perforation. Am J Otolaryngol 2016; 37 (2): 156–61.
22.Kanemaru S, Umeda H, Yamashita M et al. Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells. Laryngoscope 2012; 123 (2): 472–6. DOI: 10.1002/lary.23626
23.Perny M, Ting C, Kleinlogel S, Senn P. Generation of Otic Sensory Neurons from Mouse Em-bryonic Stem Cells in 3D Culture. Front Cell Neurosci 2017; 11: 1–12.
24.Fulco I, Miot S, Haug MD et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet 2014; 6736 (14): 1–10.
25.Lee CH, Jeon S, Seo BS, Mo J. Transplantation of Neural Stem Cells in Anosmic Mice. Clin Ex-per Otorhinolaryngol 2010; 3 (2): 84–90.
26.Xu X, Li L, Wang C et al. The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue. Cell Biosci 2015; 5 (1).
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Авторы
Свистушкин Валерий Михайлович – д-р мед. наук, проф., зав. каф. болезней уха, горла и носа Института клинической медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет). E-mail: svvm3@yandex.ru; ORCID: https://orcid.org/0000-0001-7414-1293
Побиванцева Анна Андреевна – клинический ординатор ФГАОУ ВО «Первый МГМУ
Svetlana V. Starostina – D. Sci. (Med.), Prof., Sechenov First Moscow State Medical University (Sechenov University). E-mail: starostina_sv@inbox.ru; ORCID: https://0000-0002-7165-1308
Mikhail V. Svistushkin – Аssistant, Sechenov First Moscow State Medical University (Sechenov University). E-mail: swistushkin@yandex.ru; ORCID: https://0000-0002-8552-1395
Anna A. Pobivantseva – Clinical Resident, Sechenov First Moscow State Medical University (Sechenov University). E-mail: www.vesta.ru@mail.ru; ORCID: https://0000-0001-9030-4056
Maksim V. Arkhipov – Student, Sechenov First Moscow State Medical University (Sechenov University). E-mail: hanter241@yandex.ru; ORCID: https://0000-0001-5474-6586
Старостина Светлана Викторовна – д-р мед. наук, проф. каф. болезней уха, горла и носа Института клинической медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет). E-mail: starostina_sv@inbox.ru; ORCID: https://0000-0002-7165-1308
Свистушкин Михаил Валерьевич – ассистент каф. болезней уха, горла и носа Института клинической медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет). E-mail: swistushkin@yandex.ru; ORCID: https://0000-0002-8552-1395Побиванцева Анна Андреевна – клинический ординатор ФГАОУ ВО «Первый МГМУ
им. И.М. Сеченова» (Сеченовский Университет). E-mail: www.vesta.ru@mail.ru;
ORCID: https://0000-0001-9030-4056
Архипов Максим Владимирович – студент 6-го курса Института здоровья детей ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет). E-mail: hanter241@yandex.ru; ORCID: https://0000-0001-5474-6586
________________________________________________
Svetlana V. Starostina – D. Sci. (Med.), Prof., Sechenov First Moscow State Medical University (Sechenov University). E-mail: starostina_sv@inbox.ru; ORCID: https://0000-0002-7165-1308
Mikhail V. Svistushkin – Аssistant, Sechenov First Moscow State Medical University (Sechenov University). E-mail: swistushkin@yandex.ru; ORCID: https://0000-0002-8552-1395
Anna A. Pobivantseva – Clinical Resident, Sechenov First Moscow State Medical University (Sechenov University). E-mail: www.vesta.ru@mail.ru; ORCID: https://0000-0001-9030-4056
Maksim V. Arkhipov – Student, Sechenov First Moscow State Medical University (Sechenov University). E-mail: hanter241@yandex.ru; ORCID: https://0000-0001-5474-6586
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