Диагностика и лечение эозинофильного эзофагита: обзор Европейских рекомендаций 2017 г.

1. Ивашкин В.Т., Баранская Е.К., Кайбышева В.О. и др. Эозинофильный эзофагит: обзор литературы и описание собственного наблюдения. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2012; 1: 71–81.
[Ivashkin V.T., Baranskaia E.K., Kaibysheva V.O. et al. Eozinofil'nyi ezofagit: obzor literatury i opisanie sobstvennogo nabliudeniia. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2012; 1: 71–81 (in Russian).]
2. Goyal A. Eosinophilic esophagitis: short and long-term considerations. Curr Opin Pediatr 2018; 30 (5): 646–52. DOI: 10.1097/MOP.0000000000000662
3. Трухманов А.С. Эозинофильный эзофагит. В кн.: Справочник по гастроэнтерологии. Под ред. В.Т.Ивашкина, С.И.Рапопорта. Изд. 2-е. М.: МИА, 2011; с. 48–9.
[Trukhmanov A.S. Eosinophilic esophagitis. In: Handbook of gastroenterology. Ed. V.T.Ivashkin, S.I.Rapoport. Edition 2nd. Moscow: MIA, 2011; p. 48–9. (in Russian).]
4. Ивашкин В.Т., Маев И.В., Трухманов А.С. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению эозинофильного эзофагита. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2018; 28 (6): 84–98.
[Ivashkin V.T., Maev I.V., Trukhmanov A.S. et al. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu eozinofil'nogo ezofagita. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2018; 28 (6): 84–98 (in Russian).]
5. Кайбышева В.О., Кашин С.В., Михалева Л.М. и др. Эозинофильный эзофагит: современный взгляд на проблему и собственные клинические наблюдения. Доказательная гастроэнтерология. 2019; 8 (1): 58–83.
[Kaibysheva V.O., Kashin S.V., Mikhaleva L.M. et al. Eozinofil'nyi ezofagit: sovremennyi vzgliad na problemu i sobstvennye klinicheskie nabliudeniia. Dokazatel'naia gastroenterologiia. 2019; 8 (1): 58–83 (in Russian).]
6. Маев И.В., Бусарова Г.А., Андреев Д.Н. Болезни пищевода. М.: ГЭОТАР-Медиа, 2019.
[Maev I.V., Busarova G.A., Andreev D.N. Diseases of the esophagus. Moscow: GEOTAR-Media, 2019 (in Russian).]
7. Lucendo AJ, Molina-Infante J, Arias Á et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J 2017; 5 (3): 335–58. DOI: 10.1177/2050640616689525
8. Трухманов А.С., Ивашкина Н.Ю. Эозинофильный эзофагит. Рациональная фармакотерапия заболеваний органов пищеварения. Под. ред. В.Т.Ивашкина. М.: Литерра, 2011; с. 267–9.
[Trukhmanov A.S., Ivashkina N.Iu. Eosinophilic esophagitis. Rational pharmacotherapy of digestive diseases. Ed. V.T.Ivashkin. Moscow: Literra, 2011; p. 267–9 (in Russian).]
9. Straumann A, Spichtin HP, Bernoulli R et al. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Schweiz Med Wochenschr 1994; 124: 1419–29.
10. Furuta GT, Liacouras CA, Collins MH et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342–63.
11. Liacouras CA, Furuta GT, Hirano I et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011; 128: 3–20.
12. Papadopoulou A, Koletzko S, Heuschkel R et al. Management guidelines of eosinophilic esophagitis in childhood. J Pediatr Gastroenterol Nutr 2014; 58: 107–18.
13. Dellon ES, Gonsalves N, Hirano I et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol 2013; 108: 679–92.
14. Lipka S, Keshishian J, Boyce HW et al. The natural history of steroid-naive eosinophilic esophagitis in adults treated with endoscopic dilation and proton pump inhibitor therapy over a mean duration of nearly 14 years. Gastrointest Endosc 2014; 80: 592–8.
15. Harris RF, Menard-Katcher C, Atkins D et al. Psychosocial dysfunction in children and adolescents with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2013; 57: 500–5.
16. Klinnert MD, Silveira L, Harris R et al. Health-related quality of life over time in children with eosinophilic esophagitis and their families. J Pediatr Gastroenterol Nutr 2014; 59: 308–16.
17. Arias A, Perez-Martinez I, Tenias JM et al. Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther 2016; 43: 3–15.
18. Veerappan GR, Perry JL, Duncan TJ et al. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol 2009; 7: 420–6.
19. Dellon ES. Epidemiology of eosinophilic esophagitis. Gastroenterol Clin North Am 2014; 43: 201–18.
20. Foroutan M, Norouzi A, Molaei M et al. Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease. Dig Dis Sci 2010; 55: 28–31.
21. Achem SR, Almansa C, Krishna M et al. Oesophageal eosinophilic infiltration in patients with noncardiac chest pain. Aliment Pharmacol Ther 2011; 33: 1194–201.
22. Ricker J, McNear S, Cassidy T et al. Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Therap Adv Gastroenterol 2011; 4: 27–35.
23. Savarino E, Tolone S, Caccaro R et al. Clinical, endoscopic, histological and radiological characteristics of Italian patients with eosinophilic oesophagitis. Dig Liver Dis 2015; 47: 1033–8.
24. Kerlin P, Jones D, Remedios M et al. Prevalence of eosinophilic esophagitis in adults with food bolus obstruction of the esophagus. J Clin Gastroenterol 2007; 41: 356–61.
25. Prasad GA, Alexander JA, Schleck CD et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol 2009; 7: 1055–61.
26. Kapel RC, Miller JK, Torres C et al. Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. Gastroenterology 2008; 134: 1316–21.
27. Castro Jimenez A, Gomez Torrijos E, Garcia Rodriguez R et al. Demographic, clinical and allergological characteristics of Eosinophilic Esophagitis in a Spanish central region. Allergol Immunopathol (Madr) 2014; 42: 407–14.
28. van Rhijn BD, Verheij J, Smout AJ et al. Rapidly increasing incidence of eosinophilic esophagitis in a large cohort. Neurogastroenterol Motil 2013; 25: 47–52.
29. González-Cervera J, Arias Á, Redondo-González O et al. The association between atopic manifestations and eosinophilic esophagitis: a systematic review and meta-analysis. Ann Allergy Asth Immunol 2017; 118 (5): 582–90. DOI: 10.1016/j.anai.2017.02.006
30. Remedios M, Campbell C, Jones DM et al. Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc 2006; 63: 3–12.
31. Croese J, Fairley SK, Masson JW et al. Clinical and endoscopic features of eosinophilic esophagitis in adults. Gastrointest Endosc 2003; 58: 516–22.
32. Spergel JM, Brown-Whitehorn TF, Beausoleil JL et al. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr 2009; 48: 30–6.
33. Saffari H, Peterson KA, Fang JC et al. Patchy eosinophil distributions in an esophagectomy specimen from a patient with eosinophilic esophagitis: Implications for endoscopic biopsy. J Allergy Clin Immunol 2012; 130: 798–800.
34. Nielsen JA, Lager DJ, Lewin M et al. The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinophilic esophagitis. Am J Gastroenterol 2014; 109: 515–20.
35. Salek J, Clayton F, Vinson Let al. Endoscopic appearance and location dictate diagnostic yield of biopsies in eosinophilic oesophagitis. Aliment Pharmacol Ther 2015; 41: 1288–95.
36. Dellon ES, Speck O, Woodward K et al. Distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy. Mod Pathol 2015; 28: 383–90.
37. Fiocca R, Mastracci L, Engström C et al. Long-term outcome of microscopic esophagitis in chronic GERD patients treated with esomeprazole or laparoscopic antireflux surgery in the LOTUS trial. Am J Gastroenterol 2010; 105: 1015–23.
38. Kim HP, Dellon ES. An Evolving Approach to the Diagnosis of Eosinophilic Esophagitis. Gastroenterol Hepatol (NY) 2018; 14 (6): 358–66.
39. Saffari H, Hoffman LH, Peterson KA et al. Electron microscopy elucidates eosinophil degranulation patterns in patients with eosinophilic esophagitis. J Allergy Clin Immunol 2014; 133: 1728–34.
40. Capocelli KE, Fernando SD, Menard-Katcher C et al. Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes. J Clin Pathol 2015; 68: 51–6.
41. Collins MH. Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Gastroenterol Clin North Am 2014; 43: 257–68.
42. Safroneeva E, Straumann A, Coslovsky M et al. Symptoms have modest accuracy in detecting endoscopic and histologic remission in adults with eosinophilic esophagitis. Gastroenterology 2016; 150: 581–90.
43. Kim HP, Vance RB, Shaheen NJ et al. The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. Clin Gastroenterol Hepatol 2012; 10: 988–96.
44. Liacouras CA, Spergel JM, Ruchelli E et al. Eosinophilic esophagitis: A 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005; 3: 1198–206.
45. Lucendo AJ, Arias A, Molina-Infante J. Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016; 14: 13–22.
46. Molina-Infante J, Ferrando-Lamana L, Ripoll C et al. Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults. Clin Gastroenterol Hepatol 2011; 9: 110–17.
47. Dellon ES, Liacouras CA. Advances in clinical management of eosinophilic esophagitis. Gastroenterology 2014; 147: 1238–54.
48. Schaefer ET, Fitzgerald JF, Molleston JP et al. Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children. Clin Gastroenterol Hepatol 2008; 6: 165–73.
49. Tan N Di, Xiao YL, Chen MH. Steroids therapy for eosinophilic esophagitis: Systematic review and meta-analysis. J Dig Dis 2015; 16: 431–42.
50. Sawas T, Dhalla S, Sayyar M et al. Systematic review with meta-analysis: pharmacological interventions for eosinophilic oesophagitis. Aliment Pharmacol Ther 2015; 41: 797–806.
51. Murali AR, Gupta A, Attar BM et al. Topical steroids in eosinophilic esophagitis: systematic review and meta-analysis of placebo controlled randomized clinical trials. J Gastroenterol Hepatol 2015; 31: 1111–9.
52. Chuang M-YA, Chinnaratha MA, Hancock DG et al. Topical steroid therapy for the treatment of eosinophilic esophagitis (EoE): a systematic review and meta-analysis. Clin Transl Gastroenterol 2015; 6: e82.
53. Straumann A, Conus S, Degen L et al. Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2011; 9: 400–9.
54. Kagalwalla AF, Sentongo TA, Ritz S et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol 2006; 4: 1097–102.
55. Henderson CJ, Abonia JP, King EC et al. Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2012; 129: 1570–8.
56. Wolf WA, Jerath MR, Sperry SLW et al. Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014; 12: 1272–9.
57. Arias A, Gonzalez-Cervera J, Tenias JM et al. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology 2014; 146: 1639–48.
58. Molina-Infante J, Arias A, Barrio J et al. Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study. J Allergy Clin Immunol 2014; 134: 1093–99.
59. Molina-Infante J, Modolell I, Alcedo J et al. Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: the 2-4-6 study. United Eur Gastroenterol J 2016; Suppl. 5: A126.
60. Gonsalves N, Yang G-Y, Doerfler B et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 2012; 142: 1451–5.
61. Lucendo AJ, Arias A, Gonzalez-Cervera J et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol 2013; 131: 797–804.
62. Kagalwalla AF, Shah A, Li BUK et al. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr 2011; 53: 145–9.
63. Moawad FJ, Cheatham JG, DeZee KJ. Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis. Aliment Pharmacol Ther 2013; 38: 713–20.

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1. Ivashkin V.T., Baranskaia E.K., Kaibysheva V.O. et al. Eozinofil'nyi ezofagit: obzor literatury i opisanie sobstvennogo nabliudeniia. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2012; 1: 71–81 (in Russian).
2. Goyal A. Eosinophilic esophagitis: short and long-term considerations. Curr Opin Pediatr 2018; 30 (5): 646–52. DOI: 10.1097/MOP.0000000000000662
3. Trukhmanov A.S. Eosinophilic esophagitis. In: Handbook of gastroenterology. Ed. V.T.Ivashkin, S.I.Rapoport. Edition 2nd. Moscow: MIA, 2011; p. 48–9. (in Russian).
4. Ivashkin V.T., Maev I.V., Trukhmanov A.S. et al. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu eozinofil'nogo ezofagita. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2018; 28 (6): 84–98 (in Russian).
5. Kaibysheva V.O., Kashin S.V., Mikhaleva L.M. et al. Eozinofil'nyi ezofagit: sovremennyi vzgliad na problemu i sobstvennye klinicheskie nabliudeniia. Dokazatel'naia gastroenterologiia. 2019; 8 (1): 58–83 (in Russian).
6. Maev I.V., Busarova G.A., Andreev D.N. Diseases of the esophagus. Moscow: GEOTAR-Media, 2019 (in Russian).
7. Lucendo AJ, Molina-Infante J, Arias Á et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J 2017; 5 (3): 335–58. DOI: 10.1177/2050640616689525
8. Trukhmanov A.S., Ivashkina N.Iu. Eosinophilic esophagitis. Rational pharmacotherapy of digestive diseases. Ed. V.T.Ivashkin. Moscow: Literra, 2011; p. 267–9 (in Russian).
9. Straumann A, Spichtin HP, Bernoulli R et al. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Schweiz Med Wochenschr 1994; 124: 1419–29.
10. Furuta GT, Liacouras CA, Collins MH et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342–63.
11. Liacouras CA, Furuta GT, Hirano I et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011; 128: 3–20.
12. Papadopoulou A, Koletzko S, Heuschkel R et al. Management guidelines of eosinophilic esophagitis in childhood. J Pediatr Gastroenterol Nutr 2014; 58: 107–18.
13. Dellon ES, Gonsalves N, Hirano I et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol 2013; 108: 679–92.
14. Lipka S, Keshishian J, Boyce HW et al. The natural history of steroid-naive eosinophilic esophagitis in adults treated with endoscopic dilation and proton pump inhibitor therapy over a mean duration of nearly 14 years. Gastrointest Endosc 2014; 80: 592–8.
15. Harris RF, Menard-Katcher C, Atkins D et al. Psychosocial dysfunction in children and adolescents with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2013; 57: 500–5.
16. Klinnert MD, Silveira L, Harris R et al. Health-related quality of life over time in children with eosinophilic esophagitis and their families. J Pediatr Gastroenterol Nutr 2014; 59: 308–16.
17. Arias A, Perez-Martinez I, Tenias JM et al. Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther 2016; 43: 3–15.
18. Veerappan GR, Perry JL, Duncan TJ et al. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol 2009; 7: 420–6.
19. Dellon ES. Epidemiology of eosinophilic esophagitis. Gastroenterol Clin North Am 2014; 43: 201–18.
20. Foroutan M, Norouzi A, Molaei M et al. Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease. Dig Dis Sci 2010; 55: 28–31.
21. Achem SR, Almansa C, Krishna M et al. Oesophageal eosinophilic infiltration in patients with noncardiac chest pain. Aliment Pharmacol Ther 2011; 33: 1194–201.
22. Ricker J, McNear S, Cassidy T et al. Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Therap Adv Gastroenterol 2011; 4: 27–35.
23. Savarino E, Tolone S, Caccaro R et al. Clinical, endoscopic, histological and radiological characteristics of Italian patients with eosinophilic oesophagitis. Dig Liver Dis 2015; 47: 1033–8.
24. Kerlin P, Jones D, Remedios M et al. Prevalence of eosinophilic esophagitis in adults with food bolus obstruction of the esophagus. J Clin Gastroenterol 2007; 41: 356–61.
25. Prasad GA, Alexander JA, Schleck CD et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol 2009; 7: 1055–61.
26. Kapel RC, Miller JK, Torres C et al. Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. Gastroenterology 2008; 134: 1316–21.
27. Castro Jimenez A, Gomez Torrijos E, Garcia Rodriguez R et al. Demographic, clinical and allergological characteristics of Eosinophilic Esophagitis in a Spanish central region. Allergol Immunopathol (Madr) 2014; 42: 407–14.
28. van Rhijn BD, Verheij J, Smout AJ et al. Rapidly increasing incidence of eosinophilic esophagitis in a large cohort. Neurogastroenterol Motil 2013; 25: 47–52.
29. González-Cervera J, Arias Á, Redondo-González O et al. The association between atopic manifestations and eosinophilic esophagitis: a systematic review and meta-analysis. Ann Allergy Asth Immunol 2017; 118 (5): 582–90. DOI: 10.1016/j.anai.2017.02.006
30. Remedios M, Campbell C, Jones DM et al. Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc 2006; 63: 3–12.
31. Croese J, Fairley SK, Masson JW et al. Clinical and endoscopic features of eosinophilic esophagitis in adults. Gastrointest Endosc 2003; 58: 516–22.
32. Spergel JM, Brown-Whitehorn TF, Beausoleil JL et al. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr 2009; 48: 30–6.
33. Saffari H, Peterson KA, Fang JC et al. Patchy eosinophil distributions in an esophagectomy specimen from a patient with eosinophilic esophagitis: Implications for endoscopic biopsy. J Allergy Clin Immunol 2012; 130: 798–800.
34. Nielsen JA, Lager DJ, Lewin M et al. The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinophilic esophagitis. Am J Gastroenterol 2014; 109: 515–20.
35. Salek J, Clayton F, Vinson Let al. Endoscopic appearance and location dictate diagnostic yield of biopsies in eosinophilic oesophagitis. Aliment Pharmacol Ther 2015; 41: 1288–95.
36. Dellon ES, Speck O, Woodward K et al. Distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy. Mod Pathol 2015; 28: 383–90.
37. Fiocca R, Mastracci L, Engström C et al. Long-term outcome of microscopic esophagitis in chronic GERD patients treated with esomeprazole or laparoscopic antireflux surgery in the LOTUS trial. Am J Gastroenterol 2010; 105: 1015–23.
38. Kim HP, Dellon ES. An Evolving Approach to the Diagnosis of Eosinophilic Esophagitis. Gastroenterol Hepatol (NY) 2018; 14 (6): 358–66.
39. Saffari H, Hoffman LH, Peterson KA et al. Electron microscopy elucidates eosinophil degranulation patterns in patients with eosinophilic esophagitis. J Allergy Clin Immunol 2014; 133: 1728–34.
40. Capocelli KE, Fernando SD, Menard-Katcher C et al. Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes. J Clin Pathol 2015; 68: 51–6.
41. Collins MH. Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Gastroenterol Clin North Am 2014; 43: 257–68.
42. Safroneeva E, Straumann A, Coslovsky M et al. Symptoms have modest accuracy in detecting endoscopic and histologic remission in adults with eosinophilic esophagitis. Gastroenterology 2016; 150: 581–90.
43. Kim HP, Vance RB, Shaheen NJ et al. The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. Clin Gastroenterol Hepatol 2012; 10: 988–96.
44. Liacouras CA, Spergel JM, Ruchelli E et al. Eosinophilic esophagitis: A 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005; 3: 1198–206.
45. Lucendo AJ, Arias A, Molina-Infante J. Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016; 14: 13–22.
46. Molina-Infante J, Ferrando-Lamana L, Ripoll C et al. Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults. Clin Gastroenterol Hepatol 2011; 9: 110–17.
47. Dellon ES, Liacouras CA. Advances in clinical management of eosinophilic esophagitis. Gastroenterology 2014; 147: 1238–54.
48. Schaefer ET, Fitzgerald JF, Molleston JP et al. Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children. Clin Gastroenterol Hepatol 2008; 6: 165–73.
49. Tan N Di, Xiao YL, Chen MH. Steroids therapy for eosinophilic esophagitis: Systematic review and meta-analysis. J Dig Dis 2015; 16: 431–42.
50. Sawas T, Dhalla S, Sayyar M et al. Systematic review with meta-analysis: pharmacological interventions for eosinophilic oesophagitis. Aliment Pharmacol Ther 2015; 41: 797–806.
51. Murali AR, Gupta A, Attar BM et al. Topical steroids in eosinophilic esophagitis: systematic review and meta-analysis of placebo controlled randomized clinical trials. J Gastroenterol Hepatol 2015; 31: 1111–9.
52. Chuang M-YA, Chinnaratha MA, Hancock DG et al. Topical steroid therapy for the treatment of eosinophilic esophagitis (EoE): a systematic review and meta-analysis. Clin Transl Gastroenterol 2015; 6: e82.
53. Straumann A, Conus S, Degen L et al. Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2011; 9: 400–9.
54. Kagalwalla AF, Sentongo TA, Ritz S et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol 2006; 4: 1097–102.
55. Henderson CJ, Abonia JP, King EC et al. Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2012; 129: 1570–8.
56. Wolf WA, Jerath MR, Sperry SLW et al. Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014; 12: 1272–9.
57. Arias A, Gonzalez-Cervera J, Tenias JM et al. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology 2014; 146: 1639–48.
58. Molina-Infante J, Arias A, Barrio J et al. Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study. J Allergy Clin Immunol 2014; 134: 1093–99.
59. Molina-Infante J, Modolell I, Alcedo J et al. Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: the 2-4-6 study. United Eur Gastroenterol J 2016; Suppl. 5: A126.
60. Gonsalves N, Yang G-Y, Doerfler B et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 2012; 142: 1451–5.
61. Lucendo AJ, Arias A, Gonzalez-Cervera J et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol 2013; 131: 797–804.
62. Kagalwalla AF, Shah A, Li BUK et al. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr 2011; 53: 145–9.
63. Moawad FJ, Cheatham JG, DeZee KJ. Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis. Aliment Pharmacol Ther 2013; 38: 713–20.
64. Netzer P, Gschossmann JM, Straumann A et al. Corticosteroid-dependent eosinophilic oesophagitis: azathioprine and 6-mercaptopurine can induce and maintain long-term remission. Eur J Gastroenterol Hepatol 2007; 19: 865–9.07; 19: 865–9.

*dna-mit8@mail.ru

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