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К вопросу о сочетании атопического дерматита и вульгарного ихтиоза
К вопросу о сочетании атопического дерматита и вульгарного ихтиоза
Мельниченко О.О., Смолкина О.Ю., Красникова В.Н. и др. К вопросу о сочетании атопического дерматита и вульгарного ихтиоза. Дерматология (Прил. к журн. Consilium Medicum). 2019; 4: 11–14. DOI: 10.26442/24143537.2019.4.190739
DOI: 10.26442/24143537.2019.4.190739
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DOI: 10.26442/24143537.2019.4.190739
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Аннотация
Атопический дерматит является распространенным кожным заболеванием. Его сочетание с вульгарным ихтиозом может достигать до 40% в некоторых популяциях. Сочетание вульгарного ихтиоза с атопическим дерматитом изменяет клиническую картину последнего. Общим звеном патогенеза данных заболеваний являются мутации гена FLG и, как следствие, нарушение барьерной функции кожи. Ввиду этого особое внимание необходимо уделять подбору адекватных увлажняющих средств, которые должны применяться на протяжении всей жизни пациентов. Назначение средств, имеющих легкую гидрофильную основу и содержащих компоненты, способствующие восстановлению защитной функции кожи, позволяет снизить клинические проявления обеих патологий.
Ключевые слова: вульгарный ихтиоз, атопический дерматит, патогенез ихтиоза и атопического дерматита, филаггрин.
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Key words: vulgar ichthyosis, atopic dermatitis, pathogenesis of ichthyosis and atopic dermatitis, filaggrin.
Полный текст
Список литературы
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19. Mathay C, Pierre M, Pittelkow MR et al. Transcriptional Profiling after Lipid Raft Disruption in Keratinocytes IdentifiesCritical Mediators of Atopic Dermatitis Pathways. J Invest Dermatol 2011; 131 (1): 46–58.
20. Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality inatopic dermatitis: Outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008; 121 (6): 1337–43.
21. Akiyama M. ABCA12 mutations and autosomal recessive congenital ichthyosis: A review of genotype/phenotype correlations and of pathogenetic concepts. Human Mutation 2010; 31 (10): 1090–6.
22. Aries MF, Hernandez-Pigeon H, Vaissière C et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosmet Investig Dermatol 2016; 9: 421–34. DOI: 10.2147/CCID.S113180
2. Atopicheskii dermatit. Klinicheskie rekomendatsii. Ministerstvo zdravookhraneniia Rossiiskoi Federatsii, 2016. [in Russian]
3. Malik K, Heitmiller KD, Czarnowicki T. An Upd ate on the Pathophysiology of Atopic Dermatitis. Dermatol Clin 2017; 35 (3): 317–26.
4. Хегер П.Г. Детская дерматология. Пер. с нем. под ред. А.А.Кубановой, А.Н.Львова. М., 2013. / Kheger P.G. Detskaia dermatologiia. Per. s nem. pod red. A.A.Kubanovoi, A.N.L'vova. M., 2013. [in Russian]
5. Maksimova Iu.V., Svechnikova E.V., Maksimov V.N. et al. Klinicheskii polimorfizm atopicheskogo dermatita i vul'garnogo ikhtioza pri mutatsiiakh v gene filaggrina. Klin. dermatologiia i venerologiia. 2015; 5: 157–64. [in Russian]
6. Sandilands A, Terron-Kwiatkowski A, Hull PR et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and raremutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007; 39: 650–4.
7. Palmer CNA, Irvine AD, Terron-Kwiatkowski A et al. Commonloss-of-function variants of the epidermal barrier protein filaggrinare a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441–6.
8. Feldman SR, Cox LS, Strowd LC et al. The Challenge of Managing Atopic Dermatitis in the United States. Am Health Drug Benefits 2019; 12 (2): 83–93.
9. Sandilands A, Sutherland C, Irvine AD, McLean WHI. Filaggrin in thefrontline: role in skin barrier function and disease. J Cell Sci 2009; 122: 1285–94.
10. Kono M. Comprehensive screening for a complete se t of Japanes-population-specific fillagrin gene mutation. Allergy 2014.
11. Thyssen JP. Ichthyosis vulgaris: the filaggrin mutation disease. Br J Dermatol 2013.
12. Hon KL. Barrier repair therapy in atopic dermatitis: an overview. Am J Clin Dermatol 2013.
13. Hubiche T, Ged C, Benard A et al. Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. Acta Derm. Venereol 2007; 87 (6): 499–505.
14. Meyer-Hoffert U. Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases. Arch Immunol Ther Exp 2009; 52 (8): 345–54.
15. Brown SJ, McLean WHI. Eczema genetics: current state of knowledge and future goals. J Invest Dermatol 2009; 129 (3): 543–52.
16. Elias PM, Ahn SK, Denda M et al. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 2002; 119 (5): 1128–36.
17. Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Experim Dermatol 2008; 17 (12): 1063–72.
18. Menon GK, Elias PM. Ultrastructural localization of calcium in psoriaticand normal human epidermis. Arch Dermatol 1991; 127 (1): 57–63.
19. Mathay C, Pierre M, Pittelkow MR et al. Transcriptional Profiling after Lipid Raft Disruption in Keratinocytes IdentifiesCritical Mediators of Atopic Dermatitis Pathways. J Invest Dermatol 2011; 131 (1): 46–58.
20. Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality inatopic dermatitis: Outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008; 121 (6): 1337–43.
21. Akiyama M. ABCA12 mutations and autosomal recessive congenital ichthyosis: A review of genotype/phenotype correlations and of pathogenetic concepts. Human Mutation 2010; 31 (10): 1090–6.
22. Aries MF, Hernandez-Pigeon H, Vaissière C et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosmet Investig Dermatol 2016; 9: 421–34. DOI: 10.2147/CCID.S113180
2. Атопический дерматит. Клинические рекомендации. Министерство здравоохранения Российской Федерации, 2016. / Atopicheskii dermatit. Klinicheskie rekomendatsii. Ministerstvo zdravookhraneniia Rossiiskoi Federatsii, 2016. [in Russian]
3. Malik K, Heitmiller KD, Czarnowicki T. An Upd ate on the Pathophysiology of Atopic Dermatitis. Dermatol Clin 2017; 35 (3): 317–26.
4. Хегер П.Г. Детская дерматология. Пер. с нем. под ред. А.А.Кубановой, А.Н.Львова. М., 2013. / Kheger P.G. Detskaia dermatologiia. Per. s nem. pod red. A.A.Kubanovoi, A.N.L'vova. M., 2013. [in Russian]
5. Максимова Ю.В., Свечникова Е.В., Максимов В.Н. и др. Клинический полиморфизм атопического дерматита и вульгарного ихтиоза при мутациях в гене филаггрина. Клин. дерматология и венерология. 2015; 5: 157–64. / Maksimova Iu.V., Svechnikova E.V., Maksimov V.N. et al. Klinicheskii polimorfizm atopicheskogo dermatita i vul'garnogo ikhtioza pri mutatsiiakh v gene filaggrina. Klin. dermatologiia i venerologiia. 2015; 5: 157–64. [in Russian]
6. Sandilands A, Terron-Kwiatkowski A, Hull PR et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and raremutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007; 39: 650–4.
7. Palmer CNA, Irvine AD, Terron-Kwiatkowski A et al. Commonloss-of-function variants of the epidermal barrier protein filaggrinare a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441–6.
8. Feldman SR, Cox LS, Strowd LC et al. The Challenge of Managing Atopic Dermatitis in the United States. Am Health Drug Benefits 2019; 12 (2): 83–93.
9. Sandilands A, Sutherland C, Irvine AD, McLean WHI. Filaggrin in thefrontline: role in skin barrier function and disease. J Cell Sci 2009; 122: 1285–94.
10. Kono M. Comprehensive screening for a complete se t of Japanes-population-specific fillagrin gene mutation. Allergy 2014.
11. Thyssen JP. Ichthyosis vulgaris: the filaggrin mutation disease. Br J Dermatol 2013.
12. Hon KL. Barrier repair therapy in atopic dermatitis: an overview. Am J Clin Dermatol 2013.
13. Hubiche T, Ged C, Benard A et al. Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. Acta Derm. Venereol 2007; 87 (6): 499–505.
14. Meyer-Hoffert U. Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases. Arch Immunol Ther Exp 2009; 52 (8): 345–54.
15. Brown SJ, McLean WHI. Eczema genetics: current state of knowledge and future goals. J Invest Dermatol 2009; 129 (3): 543–52.
16. Elias PM, Ahn SK, Denda M et al. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 2002; 119 (5): 1128–36.
17. Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Experim Dermatol 2008; 17 (12): 1063–72.
18. Menon GK, Elias PM. Ultrastructural localization of calcium in psoriaticand normal human epidermis. Arch Dermatol 1991; 127 (1): 57–63.
19. Mathay C, Pierre M, Pittelkow MR et al. Transcriptional Profiling after Lipid Raft Disruption in Keratinocytes IdentifiesCritical Mediators of Atopic Dermatitis Pathways. J Invest Dermatol 2011; 131 (1): 46–58.
20. Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality inatopic dermatitis: Outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008; 121 (6): 1337–43.
21. Akiyama M. ABCA12 mutations and autosomal recessive congenital ichthyosis: A review of genotype/phenotype correlations and of pathogenetic concepts. Human Mutation 2010; 31 (10): 1090–6.
22. Aries MF, Hernandez-Pigeon H, Vaissière C et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosmet Investig Dermatol 2016; 9: 421–34. DOI: 10.2147/CCID.S113180
________________________________________________
2. Atopicheskii dermatit. Klinicheskie rekomendatsii. Ministerstvo zdravookhraneniia Rossiiskoi Federatsii, 2016. [in Russian]
3. Malik K, Heitmiller KD, Czarnowicki T. An Upd ate on the Pathophysiology of Atopic Dermatitis. Dermatol Clin 2017; 35 (3): 317–26.
4. Хегер П.Г. Детская дерматология. Пер. с нем. под ред. А.А.Кубановой, А.Н.Львова. М., 2013. / Kheger P.G. Detskaia dermatologiia. Per. s nem. pod red. A.A.Kubanovoi, A.N.L'vova. M., 2013. [in Russian]
5. Maksimova Iu.V., Svechnikova E.V., Maksimov V.N. et al. Klinicheskii polimorfizm atopicheskogo dermatita i vul'garnogo ikhtioza pri mutatsiiakh v gene filaggrina. Klin. dermatologiia i venerologiia. 2015; 5: 157–64. [in Russian]
6. Sandilands A, Terron-Kwiatkowski A, Hull PR et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and raremutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007; 39: 650–4.
7. Palmer CNA, Irvine AD, Terron-Kwiatkowski A et al. Commonloss-of-function variants of the epidermal barrier protein filaggrinare a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441–6.
8. Feldman SR, Cox LS, Strowd LC et al. The Challenge of Managing Atopic Dermatitis in the United States. Am Health Drug Benefits 2019; 12 (2): 83–93.
9. Sandilands A, Sutherland C, Irvine AD, McLean WHI. Filaggrin in thefrontline: role in skin barrier function and disease. J Cell Sci 2009; 122: 1285–94.
10. Kono M. Comprehensive screening for a complete se t of Japanes-population-specific fillagrin gene mutation. Allergy 2014.
11. Thyssen JP. Ichthyosis vulgaris: the filaggrin mutation disease. Br J Dermatol 2013.
12. Hon KL. Barrier repair therapy in atopic dermatitis: an overview. Am J Clin Dermatol 2013.
13. Hubiche T, Ged C, Benard A et al. Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. Acta Derm. Venereol 2007; 87 (6): 499–505.
14. Meyer-Hoffert U. Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases. Arch Immunol Ther Exp 2009; 52 (8): 345–54.
15. Brown SJ, McLean WHI. Eczema genetics: current state of knowledge and future goals. J Invest Dermatol 2009; 129 (3): 543–52.
16. Elias PM, Ahn SK, Denda M et al. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 2002; 119 (5): 1128–36.
17. Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Experim Dermatol 2008; 17 (12): 1063–72.
18. Menon GK, Elias PM. Ultrastructural localization of calcium in psoriaticand normal human epidermis. Arch Dermatol 1991; 127 (1): 57–63.
19. Mathay C, Pierre M, Pittelkow MR et al. Transcriptional Profiling after Lipid Raft Disruption in Keratinocytes IdentifiesCritical Mediators of Atopic Dermatitis Pathways. J Invest Dermatol 2011; 131 (1): 46–58.
20. Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality inatopic dermatitis: Outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008; 121 (6): 1337–43.
21. Akiyama M. ABCA12 mutations and autosomal recessive congenital ichthyosis: A review of genotype/phenotype correlations and of pathogenetic concepts. Human Mutation 2010; 31 (10): 1090–6.
22. Aries MF, Hernandez-Pigeon H, Vaissière C et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosmet Investig Dermatol 2016; 9: 421–34. DOI: 10.2147/CCID.S113180
Авторы
О.О. Мельниченко1, О.Ю. Смолкина2, В.Н. Красникова1, А.Л. Пирузян3, И.М. Корсунская*1,3
1 ГБУЗ «Московский научно-практический центр дерматовенерологии и косметологии» Департамента здравоохранения г. Москвы, Москва, Россия;
2 Научно-клинический консультативный центр аллергологии и иммунологии, Москва, Россия;
3 ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН, Москва, Россия
*marykor@bk.ru
1 Moscow Scientific and Practical Center of Dermatology
and Venereology and Cosmetology, Moscow, Russia;
2 Scientific Clinical Advisory Center for Allergology
and Immunology, Moscow, Russia;
3 Center for Theoretical Problems of Physicochemical Pharmacology, Moscow, Russia
*marykor@bk.ru
1 ГБУЗ «Московский научно-практический центр дерматовенерологии и косметологии» Департамента здравоохранения г. Москвы, Москва, Россия;
2 Научно-клинический консультативный центр аллергологии и иммунологии, Москва, Россия;
3 ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН, Москва, Россия
*marykor@bk.ru
________________________________________________
1 Moscow Scientific and Practical Center of Dermatology
and Venereology and Cosmetology, Moscow, Russia;
2 Scientific Clinical Advisory Center for Allergology
and Immunology, Moscow, Russia;
3 Center for Theoretical Problems of Physicochemical Pharmacology, Moscow, Russia
*marykor@bk.ru
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