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Особенности применения серебросодержащих кремов для местного консервативного лечения ожогов. Обзор литературы
DOI: 10.26442/26583739.2019.1.190274
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Bobrovnikov A.E., Alekseev A.A. Special aspects of application of silver containing creams for local conservative treatment of burns. Literature review. Gastroenterology. Surgery. Intensive care. Consilium Medicum. 2019; 1: 63–69.
DOI: 10.26442/26583739.2019.1.190274
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Ключевые слова: ожоги, местное консервативное лечение, серебросодержащие кремы.
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The article presents the history, features, and optimal technology of applying silver-containing creams for local treatment of burns, analysis of their effectiveness in comparison with modern dressings. The peculiarity of burn management when using silver-containing creams is not only their antimicrobial action, but also creation of a moist wound environment, which is physiological for reparation processes.
Key words: burns, local conservative treatment, silver-containing creams.
2. Klasen HJ. Historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns 2000; 26 (2): 131–8.
3. White RJ. An historical overview of the use of silver in wound management. Br J Nurs 2001; 10 (15; Suppl. 2): 53–8.
4. Moyer C, Brentano L, Gravens DL et al. Treatment of large human burns with 0,5% silver nitrate solution. Arch Surg 1965; 90: 812–67.
5. Fox CL. Silver sulfadiazine: a new topical therapy for pseudomonas in burns. Arch Surg 1968; 96: 184.
6. Kjolseth D, Frank JM, Barker JH et al. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. J Am College Surgeons 1994; 179: 305–12.
7. Monafo WW, West MA. Current treatment recommendations for topical burn therapy. Drugs 1990; 40: 364–73.
8. Hyakusoku H et al. (eds.) Color Atlas of Burn Reconstructive Surgery. Springer-Verlag Berlin Heidelberg, 2010.
9. Swain AH, Azadian BS, Wakeley C, Shakespeare PG. Management of blisters in burns. BMJ 1987; 295: 181.
10. Stern HS. Silver sulphadiazine and the healing of partial thickness burns: a prospective clinical trial. Br J Plast Surg 1989; 42: 581–5.
11. Chung YJ, Herbert ME. Myth: silver sulfadiazine is the best treatment for minor burns. West J Med 2001; 175: 205–6.
12. Saffle JR, Schnebly WA. Burn wound care. In: S.L.Richard, M.J.Staley, editors. Burn Care in Rehabilitation: Principles and Practice. FA Davis Co; Philadelphia, PA, 1994; p. 7–139, 174.
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15. Grabosch A, Menzel H, Schrader M et al. Bacteriological results of a Cerium Nitrate – SSD – aulticenter study. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 315.
16. Wasserman D, Cuelfi M, Schlotterer M et al. Topical use of Cerium Nitrate added to siver sulfadiazine. Clinical results in major burns and local effects on wounds The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 316.
17. Boeckx W, Blondeel P, Van deer Steen et al. The effect of cerium-nitrate silver sulfadiazine on the treatment of deep dermal burns: a histological hypothesis. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 318.
18. Hansbrough JF, Achauer B, Dawson J et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J Burn Care Rehabil 1995; 16 (3): 241–7.
19. Zhang L, Li X, Wing C, Xie S. The 13th Congress of the International Society for Burn Injuries. Brazilia, 2006; p. 13.
20. Fox CL et al. Topical chemotherapy for burns using cerium salts and silver sulfadiazine. Surg Gynec Obstet 1977; 144: 668.
21. Ross DA, Phipps AJ, Clarke JA. The use of cerium nitrate-silver sulphadiazine as a topical burns dressing. Br J Plast Surg 1993; 46: 582–4.
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25. Garner JP, Heppell PSJ. The use of Flammacerium in British Burns Units. Burns 2005; 31 (I. 3): 379–82.
26. Lowberry EJL. Prophylacsis and treatment for infection of burns. Brit J Hosp Med 1976;
p. 566–71.
27. De Gracia CG. An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 2001; 27 (1): 67–74.
28. Oen IM, van Baar ME, Middelkoop E, Nieuwenhuis MK. Effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns: a multicenter, randomized, controlled trial. Plast Reconstr Surg 2012; 130 (2): 274–83.
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31. Hilton JR, Williams DT, Beuker B et al. Wound dressings in diabetic foot disease. Clin Infect Dis 2004; 39 (Suppl. 2): 100–3.
32. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
33. Caruso DM, Foster KN, Hermans MH, Rick C. Aquacel Ag in the management of partial-thickness burns: results of a clinical trial. J Burn Care Rehabil 2004; 25 (1): 89–97.
34. Chatterjee DS. A controlled comparative study of the use of porcine xenograft in the treatment of partial-thickness skin loss in an occupational health centre. Curr Med Res Opin 1978; 5 (9): 726–33.
35. Vloemans AF, Middelkoop E, Kreis RW. A historical appraisal of the use of cryopreserved and glycerol-preserved allograft skin in the treatment of partial-thickness burns. Burns 2002; 28 (Suppl. 1): 16–20.
36. Hussain S, Ferguson C. Best evidence topic report. Silver sulphadiazine cream in burns. Emerg Med J 2006; 23 (12): 929.
37. Lloyd EC, Michener M, Williams MS. Outpatient burns: prevention and care. Am Fam Physician 2012; 85 (9): 25–32.
38. Wasiak J, Cleland H, Campbell F, Spinks A. Dressings for superficial and partial thickness burns. Editorial Group: Cochrane Wounds Group. Published Online: 28 mar 2013. DOI: 10.1002/14651858.CD002106.pub4
39. Waffle C, Simon RR, Joslin C. Moisture-vapour-permeable film as an outpatient burn dressing. Burns Incl Therm Inj 1988; 14 (1): 66–70.
40. Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M et al. Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database Syst Rev 2013; 6.
41. Sheridan R, Petera L, Lydon M et al. Once-daily wound cleansing and dressing change: efficacy and cost. J Burn Care Rehabil 1997; 18: 139–40.
42. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
43. Fong J, Wood F, Fowler B. A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: comparative patient care audits. Burns 2005; 31 (5): 562–7.
44. Caruso DM, Foster KN, Blome-Eberwein SA et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns.
J Burn Care Res 2006; 27 (3): 298–309.
45. Argirova M, Hadjiiski O. Application of the Nanocrystalline Silver in Treatment of Burn Wounds in Children. In: Dr. Spear M. (ed). Skin Grafts – Indications, Applications and Current Research. 2011; p. 237–64.
46. Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns 2004; 30 (Suppl. 1): 1–9.
47. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 2003; 27: 341–53.
48. Silver S, Phung LT, Silver G. Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds. J Ind Microbiol Biotechnol 2006; 33 (7): 627–34.
49. Heggers JP, Goodheart RE, Washington J et al. Therapeutic Efficacy of Three Silver Dressings in an Infected Animal Model. J Burn Care Rehabil 2005; 26 (1): 53–6.
50. Leaper DJ. Silver dressings: their role in wound management. Int Wound J 2006; 3 (4): 282–94.
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[Alekseev A.A., Bobrovnikov A.E., Terekhova R.P., Krutikov M.G. Mikrobiologicheskaia otsenka effektivnosti sovremennykh antimikrobnykh preparatov dlia mestnogo lecheniia ozhogovykh ran. Kombustiologiia (elektronnyi zhurnal). 2009; 36 (in Russian).]
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53. Marshall JP, Schneider RP. Systemic argyria secondary to topical silver nitrate. Arch Dermatol 1977; 113: 1077–9.
54. Lansdown AB. Silver. 1. Its antibacterial properties and mechanism of action. J Wound Care 2002; 11: 125–30.
55. Lansdown AB. Silver. 2. Toxicity in mammals and how its products aid wound repair.
J Wound Care 2002; 11: 173–7.
56. Lee AR, Moon HK. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound. Arch Pharm Res 2003; 26 (10): 855–60.
57. Poon VK, Burd A. In vitro cytotoxicity of silver: implication for clinical wound care. Burns 2004; 30 (2): 140–7.
58. Chen J, Han CM, Yu CH. Change in sliver metabolism after the application of nanometer silver on burn wound. Zhonghua Shao Shang Za Zhi 2004; 20 (3): 161–3.
59. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
60. Lansdown AB, Williams A, Chandler S, Benfield S. Silver absorption and antibacterial efficacy of silver dressings. J Wound Care 2005; 14 (4): 155–60.
61. Trop M. Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma 2006; 61 (4): 1024.
62. Paddle-Ledinek J, Nasa Z, Cleland H. Effect of Different Wound Dressings on Cell Viability and Proliferation. Plastic Reconstructive Surg 2006; 117 (I. 75): 1105–85.
63. Burd A, Ahmed K, Lam S et al. Stem cell strategies in burns care. Burns 2007; 33: 282–91.
64. Fong J, Wood F. Nanocrystalline silver dressings in wound management: a review. Int J Nanomedicine 2006; 1 (4): 441–9.
65. EuroMedNews, 2011. http://euromednews.ru/2011/09/nanoserebro-opasno-dlya-zdorovya/
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74. Hussain S, Ferguson C. Best evidence topic report. Silver sulphadiazine cream in burns. Emerg Med J 2006; 23 (12): 929.
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1. Klasen HJ. Historical review of the use of silver in the treatment of burns. I. Early uses. Burns 2000; 26: 117–30.
2. Klasen HJ. Historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns 2000; 26 (2): 131–8.
3. White RJ. An historical overview of the use of silver in wound management. Br J Nurs 2001; 10 (15; Suppl. 2): 53–8.
4. Moyer C, Brentano L, Gravens DL et al. Treatment of large human burns with 0,5% silver nitrate solution. Arch Surg 1965; 90: 812–67.
5. Fox CL. Silver sulfadiazine: a new topical therapy for pseudomonas in burns. Arch Surg 1968; 96: 184.
6. Kjolseth D, Frank JM, Barker JH et al. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. J Am College Surgeons 1994; 179: 305–12.
7. Monafo WW, West MA. Current treatment recommendations for topical burn therapy. Drugs 1990; 40: 364–73.
8. Hyakusoku H et al. (eds.) Color Atlas of Burn Reconstructive Surgery. Springer-Verlag Berlin Heidelberg, 2010.
9. Swain AH, Azadian BS, Wakeley C, Shakespeare PG. Management of blisters in burns. BMJ 1987; 295: 181.
10. Stern HS. Silver sulphadiazine and the healing of partial thickness burns: a prospective clinical trial. Br J Plast Surg 1989; 42: 581–5.
11. Chung YJ, Herbert ME. Myth: silver sulfadiazine is the best treatment for minor burns. West J Med 2001; 175: 205–6.
12. Saffle JR, Schnebly WA. Burn wound care. In: S.L.Richard, M.J.Staley, editors. Burn Care in Rehabilitation: Principles and Practice. FA Davis Co; Philadelphia, PA, 1994; p. 7–139, 174.
13. Dekock M, Van Der Merwe A, Swarts CA. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 359.
14. Zinov'ev E.V., Chichkov O.V., Kovalenko A.V., Konovalov S.V. Eksperimental'no-klinicheskaia otsenka effektivnosti mestnogo lecheniia ozhogovykh ran maz'iu sul'fadiazina serebra s epidermal'nym faktorom rosta. Meditsina XXI vek. 2007; 8 (9): 48–53 (in Russian).
15. Grabosch A, Menzel H, Schrader M et al. Bacteriological results of a Cerium Nitrate – SSD – aulticenter study. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 315.
16. Wasserman D, Cuelfi M, Schlotterer M et al. Topical use of Cerium Nitrate added to siver sulfadiazine. Clinical results in major burns and local effects on wounds The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 316.
17. Boeckx W, Blondeel P, Van deer Steen et al. The effect of cerium-nitrate silver sulfadiazine on the treatment of deep dermal burns: a histological hypothesis. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 318.
18. Hansbrough JF, Achauer B, Dawson J et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J Burn Care Rehabil 1995; 16 (3): 241–7.
19. Zhang L, Li X, Wing C, Xie S. The 13th Congress of the International Society for Burn Injuries. Brazilia, 2006; p. 13.
20. Fox CL et al. Topical chemotherapy for burns using cerium salts and silver sulfadiazine. Surg Gynec Obstet 1977; 144: 668.
21. Ross DA, Phipps AJ, Clarke JA. The use of cerium nitrate-silver sulphadiazine as a topical burns dressing. Br J Plast Surg 1993; 46: 582–4.
22. Rodionov P.P. Serebro v meditsine, biologii i tekhnike. Sb. trud. Vyp. 5. Novosibirsk: Institut klinicheskoi immunologii SO RAMN, 1996 (in Russian).
23. Hadjiiski OG, Lesseva MI. Comparison of four drugs for local treatment of burn wounds. Eur J Emerg Med 1999; 6 (1): 41–7.
24. Burmistrov V.A. Opyt primeneniia novykh serebrosoderzhashchikh preparatov ZAO «Vektor-Best». Novosti «Vektor-Best». 2001; 2 (20) (in Russian).
25. Garner JP, Heppell PSJ. The use of Flammacerium in British Burns Units. Burns 2005; 31 (I. 3): 379–82.
26. Lowberry EJL. Prophylacsis and treatment for infection of burns. Brit J Hosp Med 1976;
p. 566–71.
27. De Gracia CG. An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 2001; 27 (1): 67–74.
28. Oen IM, van Baar ME, Middelkoop E, Nieuwenhuis MK. Effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns: a multicenter, randomized, controlled trial. Plast Reconstr Surg 2012; 130 (2): 274–83.
29. Paramonov B.A., Porembskii Ia.O., Iablonskii V.G. Ozhogi. Rukovodstvo dlia vrachei. Saint Petersburg: SpetsLit, 2000 (in Russian).
30. Krutikov M.G., Lagvilava M.G. Primenenie serebrosoderzhashchikh kremov dlia lecheniia ozhogovykh ran. Sbornik nauchnykh trudov II s"ezda kombustiologov Rossii, Moscow. 2008; c. 141–2 (in Russian).
31. Hilton JR, Williams DT, Beuker B et al. Wound dressings in diabetic foot disease. Clin Infect Dis 2004; 39 (Suppl. 2): 100–3.
32. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
33. Caruso DM, Foster KN, Hermans MH, Rick C. Aquacel Ag in the management of partial-thickness burns: results of a clinical trial. J Burn Care Rehabil 2004; 25 (1): 89–97.
34. Chatterjee DS. A controlled comparative study of the use of porcine xenograft in the treatment of partial-thickness skin loss in an occupational health centre. Curr Med Res Opin 1978; 5 (9): 726–33.
35. Vloemans AF, Middelkoop E, Kreis RW. A historical appraisal of the use of cryopreserved and glycerol-preserved allograft skin in the treatment of partial-thickness burns. Burns 2002; 28 (Suppl. 1): 16–20.
36. Hussain S, Ferguson C. Best evidence topic report. Silver sulphadiazine cream in burns. Emerg Med J 2006; 23 (12): 929.
37. Lloyd EC, Michener M, Williams MS. Outpatient burns: prevention and care. Am Fam Physician 2012; 85 (9): 25–32.
38. Wasiak J, Cleland H, Campbell F, Spinks A. Dressings for superficial and partial thickness burns. Editorial Group: Cochrane Wounds Group. Published Online: 28 mar 2013. DOI: 10.1002/14651858.CD002106.pub4
39. Waffle C, Simon RR, Joslin C. Moisture-vapour-permeable film as an outpatient burn dressing. Burns Incl Therm Inj 1988; 14 (1): 66–70.
40. Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M et al. Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database Syst Rev 2013; 6.
41. Sheridan R, Petera L, Lydon M et al. Once-daily wound cleansing and dressing change: efficacy and cost. J Burn Care Rehabil 1997; 18: 139–40.
42. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
43. Fong J, Wood F, Fowler B. A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: comparative patient care audits. Burns 2005; 31 (5): 562–7.
44. Caruso DM, Foster KN, Blome-Eberwein SA et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns.
J Burn Care Res 2006; 27 (3): 298–309.
45. Argirova M, Hadjiiski O. Application of the Nanocrystalline Silver in Treatment of Burn Wounds in Children. In: Dr. Spear M. (ed). Skin Grafts – Indications, Applications and Current Research. 2011; p. 237–64.
46. Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns 2004; 30 (Suppl. 1): 1–9.
47. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 2003; 27: 341–53.
48. Silver S, Phung LT, Silver G. Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds. J Ind Microbiol Biotechnol 2006; 33 (7): 627–34.
49. Heggers JP, Goodheart RE, Washington J et al. Therapeutic Efficacy of Three Silver Dressings in an Infected Animal Model. J Burn Care Rehabil 2005; 26 (1): 53–6.
50. Leaper DJ. Silver dressings: their role in wound management. Int Wound J 2006; 3 (4): 282–94.
51. Alekseev A.A., Bobrovnikov A.E., Terekhova R.P., Krutikov M.G. Mikrobiologicheskaia otsenka effektivnosti sovremennykh antimikrobnykh preparatov dlia mestnogo lecheniia ozhogovykh ran. Kombustiologiia (elektronnyi zhurnal). 2009; 36 (in Russian).
52. Bobrovnikov A.E. Tekhnologii mestnogo konservativnoi lecheniia obozhzhennykh. Avtoref. dis. … d-ra med. nauk. M., 2012 (in Russian).
53. Marshall JP, Schneider RP. Systemic argyria secondary to topical silver nitrate. Arch Dermatol 1977; 113: 1077–9.
54. Lansdown AB. Silver. 1. Its antibacterial properties and mechanism of action. J Wound Care 2002; 11: 125–30.
55. Lansdown AB. Silver. 2. Toxicity in mammals and how its products aid wound repair.
J Wound Care 2002; 11: 173–7.
56. Lee AR, Moon HK. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound. Arch Pharm Res 2003; 26 (10): 855–60.
57. Poon VK, Burd A. In vitro cytotoxicity of silver: implication for clinical wound care. Burns 2004; 30 (2): 140–7.
58. Chen J, Han CM, Yu CH. Change in sliver metabolism after the application of nanometer silver on burn wound. Zhonghua Shao Shang Za Zhi 2004; 20 (3): 161–3.
59. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
60. Lansdown AB, Williams A, Chandler S, Benfield S. Silver absorption and antibacterial efficacy of silver dressings. J Wound Care 2005; 14 (4): 155–60.
61. Trop M. Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma 2006; 61 (4): 1024.
62. Paddle-Ledinek J, Nasa Z, Cleland H. Effect of Different Wound Dressings on Cell Viability and Proliferation. Plastic Reconstructive Surg 2006; 117 (I. 75): 1105–85.
63. Burd A, Ahmed K, Lam S et al. Stem cell strategies in burns care. Burns 2007; 33: 282–91.
64. Fong J, Wood F. Nanocrystalline silver dressings in wound management: a review. Int J Nanomedicine 2006; 1 (4): 441–9.
65. EuroMedNews, 2011. http://euromednews.ru/2011/09/nanoserebro-opasno-dlya-zdorovya/
66. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
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1. ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2. ФГБУ «Национальный медицинский исследовательский центр хирургии им. А.В.Вишневского» Минздрава России, Москва, Россия
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Aleksandr E. Bobrovnikov, Andrey A. Alekseev
1. Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2. A.V.Vishnevsky National Medical Research Center of Surgery, Moscow, Russia