Особенности применения серебросодержащих кремов для местного консервативного лечения ожогов. Обзор литературы

1. Klasen HJ. Historical review of the use of silver in the treatment of burns. I. Early uses. Burns 2000; 26: 117–30.
2. Klasen HJ. Historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns 2000; 26 (2): 131–8.
3. White RJ. An historical overview of the use of silver in wound management. Br J Nurs 2001; 10 (15; Suppl. 2): 53–8.
4. Moyer C, Brentano L, Gravens DL et al. Treatment of large human burns with 0,5% silver nitrate solution. Arch Surg 1965; 90: 812–67.
5. Fox CL. Silver sulfadiazine: a new topical therapy for pseudomonas in burns. Arch Surg 1968; 96: 184.
6. Kjolseth D, Frank JM, Barker JH et al. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. J Am College Surgeons 1994; 179: 305–12.
7. Monafo WW, West MA. Current treatment recommendations for topical burn therapy. Drugs 1990; 40: 364–73.
8. Hyakusoku H et al. (eds.) Color Atlas of Burn Reconstructive Surgery. Springer-Verlag Berlin Heidelberg, 2010.
9. Swain AH, Azadian BS, Wakeley C, Shakespeare PG. Management of blisters in burns. BMJ 1987; 295: 181.
10. Stern HS. Silver sulphadiazine and the healing of partial thickness burns: a prospective clinical trial. Br J Plast Surg 1989; 42: 581–5.
11. Chung YJ, Herbert ME. Myth: silver sulfadiazine is the best treatment for minor burns. West J Med 2001; 175: 205–6.
12. Saffle JR, Schnebly WA. Burn wound care. In: S.L.Richard, M.J.Staley, editors. Burn Care in Rehabilitation: Principles and Practice. FA Davis Co; Philadelphia, PA, 1994; p. 7–139, 174.
13. Dekock M, Van Der Merwe A, Swarts CA. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 359.
14. Зиновьев Е.В., Чичков О.В., Коваленко А.В., Коновалов С.В. Экспериментально-клиническая оценка эффективности местного лечения ожоговых ран мазью сульфадиазина серебра с эпидермальным фактором роста. Медицина XXI век. 2007; 
8 (9): 48–53.
[Zinov'ev E.V., Chichkov O.V., Kovalenko A.V., Konovalov S.V. Eksperimental'no-klinicheskaia otsenka effektivnosti mestnogo lecheniia ozhogovykh ran maz'iu sul'fadiazina serebra s epidermal'nym faktorom rosta. Meditsina XXI vek. 2007; 8 (9): 48–53 (in Russian).]
15. Grabosch A, Menzel H, Schrader M et al. Bacteriological results of a Cerium Nitrate – SSD – aulticenter study. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 315.
16. Wasserman D, Cuelfi M, Schlotterer M et al. Topical use of Cerium Nitrate added to siver sulfadiazine. Clinical results in major burns and local effects on wounds The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 316.
17. Boeckx W, Blondeel P, Van deer Steen et al. The effect of cerium-nitrate silver sulfadiazine on the treatment of deep dermal burns: a histological hypothesis. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 318.
18. Hansbrough JF, Achauer B, Dawson J et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J Burn Care Rehabil 1995; 16 (3): 241–7.
19. Zhang L, Li X, Wing C, Xie S. The 13th Congress of the International Society for Burn Injuries. Brazilia, 2006; p. 13.
20. Fox CL et al. Topical chemotherapy for burns using cerium salts and silver sulfadiazine. Surg Gynec Obstet 1977; 144: 668.
21. Ross DA, Phipps AJ, Clarke JA. The use of cerium nitrate-silver sulphadiazine as a topical burns dressing. Br J Plast Surg 1993; 46: 582–4.
22. Родионов П.П. Серебро в медицине, биологии и технике. Сб. труд. Вып. 5. Новосибирск: Институт клинической иммунологии СО РАМН, 1996.
[Rodionov P.P. Serebro v meditsine, biologii i tekhnike. Sb. trud. Vyp. 5. Novosibirsk: Institut klinicheskoi immunologii SO RAMN, 1996 (in Russian).]
23. Hadjiiski OG, Lesseva MI. Comparison of four drugs for local treatment of burn wounds. Eur J Emerg Med 1999; 6 (1): 41–7.
24. Бурмистров В.А. Опыт применения новых серебросодержащих препаратов ЗАО «Вектор-Бест». Новости «Вектор-Бест». 2001; 2 (20).
[Burmistrov V.A. Opyt primeneniia novykh serebrosoderzhashchikh preparatov ZAO «Vektor-Best». Novosti «Vektor-Best». 2001; 2 (20) (in Russian).]
25. Garner JP, Heppell PSJ. The use of Flammacerium in British Burns Units. Burns 2005; 31 (I. 3): 379–82.
26. Lowberry EJL. Prophylacsis and treatment for infection of burns. Brit J Hosp Med 1976; 
p. 566–71.
27. De Gracia CG. An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 2001; 27 (1): 67–74.
28. Oen IM, van Baar ME, Middelkoop E, Nieuwenhuis MK. Effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns: a multicenter, randomized, controlled trial. Plast Reconstr Surg 2012; 130 (2): 274–83.
29. Парамонов Б.А., Порембский Я.О., Яблонский В.Г. Ожоги. Руководство для врачей. СПб.: СпецЛит, 2000.
[Paramonov B.A., Porembskii Ia.O., Iablonskii V.G. Ozhogi. Rukovodstvo dlia vrachei. Saint Petersburg: SpetsLit, 2000 (in Russian).]
30. Крутиков М.Г., Лагвилава М.Г. Применение серебросодержащих кремов для лечения ожоговых ран. Сборник научных трудов II съезда комбустиологов России, М., 2008; c. 141–2.
[Krutikov M.G., Lagvilava M.G. Primenenie serebrosoderzhashchikh kremov dlia lecheniia ozhogovykh ran. Sbornik nauchnykh trudov II s"ezda kombustiologov Rossii, Moscow. 2008; c. 141–2 (in Russian).]
31. Hilton JR, Williams DT, Beuker B et al. Wound dressings in diabetic foot disease. Clin Infect Dis 2004; 39 (Suppl. 2): 100–3.
32. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
33. Caruso DM, Foster KN, Hermans MH, Rick C. Aquacel Ag in the management of partial-thickness burns: results of a clinical trial. J Burn Care Rehabil 2004; 25 (1): 89–97.
34. Chatterjee DS. A controlled comparative study of the use of porcine xenograft in the treatment of partial-thickness skin loss in an occupational health centre. Curr Med Res Opin 1978; 5 (9): 726–33.
35. Vloemans AF, Middelkoop E, Kreis RW. A historical appraisal of the use of cryopreserved and glycerol-preserved allograft skin in the treatment of partial-thickness burns. Burns 2002; 28 (Suppl. 1): 16–20.
36. Hussain S, Ferguson C. Best evidence topic report. Silver sulphadiazine cream in burns. Emerg Med J 2006; 23 (12): 929.
37. Lloyd EC, Michener M, Williams MS. Outpatient burns: prevention and care. Am Fam Physician 2012; 85 (9): 25–32.
38. Wasiak J, Cleland H, Campbell F, Spinks A. Dressings for superficial and partial thickness burns. Editorial Group: Cochrane Wounds Group. Published Online: 28 mar 2013. DOI: 10.1002/14651858.CD002106.pub4
39. Waffle C, Simon RR, Joslin C. Moisture-vapour-permeable film as an outpatient burn dressing. Burns Incl Therm Inj 1988; 14 (1): 66–70.
40. Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M et al. Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database Syst Rev 2013; 6.
41. Sheridan R, Petera L, Lydon M et al. Once-daily wound cleansing and dressing change: efficacy and cost. J Burn Care Rehabil 1997; 18: 139–40.
42. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
43. Fong J, Wood F, Fowler B. A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: comparative patient care audits. Burns 2005; 31 (5): 562–7.
44. Caruso DM, Foster KN, Blome-Eberwein SA et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. 
J Burn Care Res 2006; 27 (3): 298–309.
45. Argirova M, Hadjiiski O. Application of the Nanocrystalline Silver in Treatment of Burn Wounds in Children. In: Dr. Spear M. (ed). Skin Grafts – Indications, Applications and Current Research. 2011; p. 237–64.
46. Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns 2004; 30 (Suppl. 1): 1–9.
47. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 2003; 27: 341–53.
48. Silver S, Phung LT, Silver G. Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds. J Ind Microbiol Biotechnol 2006; 33 (7): 627–34.
49. Heggers JP, Goodheart RE, Washington J et al. Therapeutic Efficacy of Three Silver Dressings in an Infected Animal Model. J Burn Care Rehabil 2005; 26 (1): 53–6.
50. Leaper DJ. Silver dressings: their role in wound management. Int Wound J 2006; 3 (4): 282–94.
51. Алексеев А.А., Бобровников А.Э., Терехова Р.П., Крутиков М.Г. Микробиологическая оценка эффективности современных антимикробных препаратов для местного лечения ожоговых ран. Комбустиология (электронный журнал). 2009; 36.
[Alekseev A.A., Bobrovnikov A.E., Terekhova R.P., Krutikov M.G. Mikrobiologicheskaia otsenka effektivnosti sovremennykh antimikrobnykh preparatov dlia mestnogo lecheniia ozhogovykh ran. Kombustiologiia (elektronnyi zhurnal). 2009; 36 (in Russian).]
52. Бобровников А.Э. Технологии местного консервативной лечения обожженных. Автореф. дис. … д-ра мед. наук. Мoscow, 2012.
[Bobrovnikov A.E. Tekhnologii mestnogo konservativnoi lecheniia obozhzhennykh. Avtoref. dis. … d-ra med. nauk. M., 2012 (in Russian).]
53. Marshall JP, Schneider RP. Systemic argyria secondary to topical silver nitrate. Arch Dermatol 1977; 113: 1077–9.
54. Lansdown AB. Silver. 1. Its antibacterial properties and mechanism of action. J Wound Care 2002; 11: 125–30.
55. Lansdown AB. Silver. 2. Toxicity in mammals and how its products aid wound repair. 
J Wound Care 2002; 11: 173–7.
56. Lee AR, Moon HK. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound. Arch Pharm Res 2003; 26 (10): 855–60.
57. Poon VK, Burd A. In vitro cytotoxicity of silver: implication for clinical wound care. Burns 2004; 30 (2): 140–7.
58. Chen J, Han CM, Yu CH. Change in sliver metabolism after the application of nanometer silver on burn wound. Zhonghua Shao Shang Za Zhi 2004; 20 (3): 161–3.
59. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
60. Lansdown AB, Williams A, Chandler S, Benfield S. Silver absorption and antibacterial efficacy of silver dressings. J Wound Care 2005; 14 (4): 155–60.
61. Trop M. Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma 2006; 61 (4): 1024.
62. Paddle-Ledinek J, Nasa Z, Cleland H. Effect of Different Wound Dressings on Cell Viability and Proliferation. Plastic Reconstructive Surg 2006; 117 (I. 75): 1105–85.
63. Burd A, Ahmed K, Lam S et al. Stem cell strategies in burns care. Burns 2007; 33: 282–91.
64. Fong J, Wood F. Nanocrystalline silver dressings in wound management: a review. Int J Nanomedicine 2006; 1 (4): 441–9.
65. EuroMedNews, 2011. http://euromednews.ru/2011/09/nanoserebro-opasno-dlya-zdorovya/
66. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
67. White R, Cutting K. Exploring the effects of silver in wound management-what is optimal? WOUNDS 2006; 18 (11): 307–14.
68. Atiyeh BS. Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthet Plast Surg 2007; 31: 468–94.
69. Ring A, Goertz O, Steinstraesser L et al. Silver ion-releasing dressing (Contreet) does not disturb angiogenesis and microvascularization in vivo. WOUNDS 2007; 19 (2): 39–45.
70. Kazmierski M, Mankowski P, Jankowski A, Harasymczuk J. Comparison of the results of operative and conservative treatment of deep dermal partial-thickness scalds in children. Eur J Pediatr Surg 2007; 17 (5): 354–61.
71. Paddock HN, Fabia R, Giles S et al. A silver-impregnated antimicrobial dressing reduces hospital costs for pediatric burn patients. J Pediatr Surg 2007; 42 (1): 211–3.
72. Lohsiriwat V, Chuangsuwanich A. Comparison of the ionic silver-containing hydrofiber and paraffin gauze dressing on split-thickness skin graft donor sites. Ann Plast Surg 2009; 62 (4): 421–2.
73. Saba SC, Tsai R, Glat P. Clinical evaluation comparing the efficacy of aquacel ag hydrofiber dressing versus petrolatum gauze with antibiotic ointment in partial-thickness burns in a pediatric burn center. J Burn Care Res 2009; 30 (3): 380–5.
74. Hussain S, Ferguson C. Best evidence topic report. Silver sulphadiazine cream in burns. Emerg Med J 2006; 23 (12): 929.
75. Storm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H. Topical silver for preventing wound infection. Cochrane Database Syst Rev 2010; 17 (3): CD006478. DOI: 10.1002/14651858.CD006478.pub2
76. Aziz Z, Abu SF, Chong NJ. A systematic review of silver-containing dressings and topical silver agents (used with dressings) for burn wounds. Burns 2012; 38 (3): 307–18.

________________________________________________

1. Klasen HJ. Historical review of the use of silver in the treatment of burns. I. Early uses. Burns 2000; 26: 117–30.
2. Klasen HJ. Historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns 2000; 26 (2): 131–8.
3. White RJ. An historical overview of the use of silver in wound management. Br J Nurs 2001; 10 (15; Suppl. 2): 53–8.
4. Moyer C, Brentano L, Gravens DL et al. Treatment of large human burns with 0,5% silver nitrate solution. Arch Surg 1965; 90: 812–67.
5. Fox CL. Silver sulfadiazine: a new topical therapy for pseudomonas in burns. Arch Surg 1968; 96: 184.
6. Kjolseth D, Frank JM, Barker JH et al. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. J Am College Surgeons 1994; 179: 305–12.
7. Monafo WW, West MA. Current treatment recommendations for topical burn therapy. Drugs 1990; 40: 364–73.
8. Hyakusoku H et al. (eds.) Color Atlas of Burn Reconstructive Surgery. Springer-Verlag Berlin Heidelberg, 2010.
9. Swain AH, Azadian BS, Wakeley C, Shakespeare PG. Management of blisters in burns. BMJ 1987; 295: 181.
10. Stern HS. Silver sulphadiazine and the healing of partial thickness burns: a prospective clinical trial. Br J Plast Surg 1989; 42: 581–5.
11. Chung YJ, Herbert ME. Myth: silver sulfadiazine is the best treatment for minor burns. West J Med 2001; 175: 205–6.
12. Saffle JR, Schnebly WA. Burn wound care. In: S.L.Richard, M.J.Staley, editors. Burn Care in Rehabilitation: Principles and Practice. FA Davis Co; Philadelphia, PA, 1994; p. 7–139, 174.
13. Dekock M, Van Der Merwe A, Swarts CA. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 359.
14. Zinov'ev E.V., Chichkov O.V., Kovalenko A.V., Konovalov S.V. Eksperimental'no-klinicheskaia otsenka effektivnosti mestnogo lecheniia ozhogovykh ran maz'iu sul'fadiazina serebra s epidermal'nym faktorom rosta. Meditsina XXI vek. 2007; 8 (9): 48–53 (in Russian).
15. Grabosch A, Menzel H, Schrader M et al. Bacteriological results of a Cerium Nitrate – SSD – aulticenter study. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 315.
16. Wasserman D, Cuelfi M, Schlotterer M et al. Topical use of Cerium Nitrate added to siver sulfadiazine. Clinical results in major burns and local effects on wounds The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 316.
17. Boeckx W, Blondeel P, Van deer Steen et al. The effect of cerium-nitrate silver sulfadiazine on the treatment of deep dermal burns: a histological hypothesis. The 8-th International Congress on Burn Injuries. New Delhi, 1990; p. 318.
18. Hansbrough JF, Achauer B, Dawson J et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J Burn Care Rehabil 1995; 16 (3): 241–7.
19. Zhang L, Li X, Wing C, Xie S. The 13th Congress of the International Society for Burn Injuries. Brazilia, 2006; p. 13.
20. Fox CL et al. Topical chemotherapy for burns using cerium salts and silver sulfadiazine. Surg Gynec Obstet 1977; 144: 668.
21. Ross DA, Phipps AJ, Clarke JA. The use of cerium nitrate-silver sulphadiazine as a topical burns dressing. Br J Plast Surg 1993; 46: 582–4.
22. Rodionov P.P. Serebro v meditsine, biologii i tekhnike. Sb. trud. Vyp. 5. Novosibirsk: Institut klinicheskoi immunologii SO RAMN, 1996 (in Russian).
23. Hadjiiski OG, Lesseva MI. Comparison of four drugs for local treatment of burn wounds. Eur J Emerg Med 1999; 6 (1): 41–7.
24. Burmistrov V.A. Opyt primeneniia novykh serebrosoderzhashchikh preparatov ZAO «Vektor-Best». Novosti «Vektor-Best». 2001; 2 (20) (in Russian).
25. Garner JP, Heppell PSJ. The use of Flammacerium in British Burns Units. Burns 2005; 31 (I. 3): 379–82.
26. Lowberry EJL. Prophylacsis and treatment for infection of burns. Brit J Hosp Med 1976; 
p. 566–71.
27. De Gracia CG. An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 2001; 27 (1): 67–74.
28. Oen IM, van Baar ME, Middelkoop E, Nieuwenhuis MK. Effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns: a multicenter, randomized, controlled trial. Plast Reconstr Surg 2012; 130 (2): 274–83.
29. Paramonov B.A., Porembskii Ia.O., Iablonskii V.G. Ozhogi. Rukovodstvo dlia vrachei. Saint Petersburg: SpetsLit, 2000 (in Russian).
30. Krutikov M.G., Lagvilava M.G. Primenenie serebrosoderzhashchikh kremov dlia lecheniia ozhogovykh ran. Sbornik nauchnykh trudov II s"ezda kombustiologov Rossii, Moscow. 2008; c. 141–2 (in Russian).
31. Hilton JR, Williams DT, Beuker B et al. Wound dressings in diabetic foot disease. Clin Infect Dis 2004; 39 (Suppl. 2): 100–3.
32. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
33. Caruso DM, Foster KN, Hermans MH, Rick C. Aquacel Ag in the management of partial-thickness burns: results of a clinical trial. J Burn Care Rehabil 2004; 25 (1): 89–97.
34. Chatterjee DS. A controlled comparative study of the use of porcine xenograft in the treatment of partial-thickness skin loss in an occupational health centre. Curr Med Res Opin 1978; 5 (9): 726–33.
35. Vloemans AF, Middelkoop E, Kreis RW. A historical appraisal of the use of cryopreserved and glycerol-preserved allograft skin in the treatment of partial-thickness burns. Burns 2002; 28 (Suppl. 1): 16–20.
36. Hussain S, Ferguson C. Best evidence topic report. Silver sulphadiazine cream in burns. Emerg Med J 2006; 23 (12): 929.
37. Lloyd EC, Michener M, Williams MS. Outpatient burns: prevention and care. Am Fam Physician 2012; 85 (9): 25–32.
38. Wasiak J, Cleland H, Campbell F, Spinks A. Dressings for superficial and partial thickness burns. Editorial Group: Cochrane Wounds Group. Published Online: 28 mar 2013. DOI: 10.1002/14651858.CD002106.pub4
39. Waffle C, Simon RR, Joslin C. Moisture-vapour-permeable film as an outpatient burn dressing. Burns Incl Therm Inj 1988; 14 (1): 66–70.
40. Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M et al. Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database Syst Rev 2013; 6.
41. Sheridan R, Petera L, Lydon M et al. Once-daily wound cleansing and dressing change: efficacy and cost. J Burn Care Rehabil 1997; 18: 139–40.
42. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil 1998; 19 (6): 531–7.
43. Fong J, Wood F, Fowler B. A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: comparative patient care audits. Burns 2005; 31 (5): 562–7.
44. Caruso DM, Foster KN, Blome-Eberwein SA et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. 
J Burn Care Res 2006; 27 (3): 298–309.
45. Argirova M, Hadjiiski O. Application of the Nanocrystalline Silver in Treatment of Burn Wounds in Children. In: Dr. Spear M. (ed). Skin Grafts – Indications, Applications and Current Research. 2011; p. 237–64.
46. Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns 2004; 30 (Suppl. 1): 1–9.
47. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 2003; 27: 341–53.
48. Silver S, Phung LT, Silver G. Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds. J Ind Microbiol Biotechnol 2006; 33 (7): 627–34.
49. Heggers JP, Goodheart RE, Washington J et al. Therapeutic Efficacy of Three Silver Dressings in an Infected Animal Model. J Burn Care Rehabil 2005; 26 (1): 53–6.
50. Leaper DJ. Silver dressings: their role in wound management. Int Wound J 2006; 3 (4): 282–94.
51. Alekseev A.A., Bobrovnikov A.E., Terekhova R.P., Krutikov M.G. Mikrobiologicheskaia otsenka effektivnosti sovremennykh antimikrobnykh preparatov dlia mestnogo lecheniia ozhogovykh ran. Kombustiologiia (elektronnyi zhurnal). 2009; 36 (in Russian).
52. Bobrovnikov A.E. Tekhnologii mestnogo konservativnoi lecheniia obozhzhennykh. Avtoref. dis. … d-ra med. nauk. M., 2012 (in Russian).
53. Marshall JP, Schneider RP. Systemic argyria secondary to topical silver nitrate. Arch Dermatol 1977; 113: 1077–9.
54. Lansdown AB. Silver. 1. Its antibacterial properties and mechanism of action. J Wound Care 2002; 11: 125–30.
55. Lansdown AB. Silver. 2. Toxicity in mammals and how its products aid wound repair. 
J Wound Care 2002; 11: 173–7.
56. Lee AR, Moon HK. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound. Arch Pharm Res 2003; 26 (10): 855–60.
57. Poon VK, Burd A. In vitro cytotoxicity of silver: implication for clinical wound care. Burns 2004; 30 (2): 140–7.
58. Chen J, Han CM, Yu CH. Change in sliver metabolism after the application of nanometer silver on burn wound. Zhonghua Shao Shang Za Zhi 2004; 20 (3): 161–3.
59. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
60. Lansdown AB, Williams A, Chandler S, Benfield S. Silver absorption and antibacterial efficacy of silver dressings. J Wound Care 2005; 14 (4): 155–60.
61. Trop M. Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma 2006; 61 (4): 1024.
62. Paddle-Ledinek J, Nasa Z, Cleland H. Effect of Different Wound Dressings on Cell Viability and Proliferation. Plastic Reconstructive Surg 2006; 117 (I. 75): 1105–85.
63. Burd A, Ahmed K, Lam S et al. Stem cell strategies in burns care. Burns 2007; 33: 282–91.
64. Fong J, Wood F. Nanocrystalline silver dressings in wound management: a review. Int J Nanomedicine 2006; 1 (4): 441–9.
65. EuroMedNews, 2011. http://euromednews.ru/2011/09/nanoserebro-opasno-dlya-zdorovya/
66. Lam PK, Chan ES, Ho WS, Liew CT. In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes. Br J Biomed Sci 2004; 61 (3): 125–7.
67. White R, Cutting K. Exploring the effects of silver in wound management-what is optimal? WOUNDS 2006; 18 (11): 307–14.
68. Atiyeh BS. Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthet Plast Surg 2007; 31: 468–94.
69. Ring A, Goertz O, Steinstraesser L et al. Silver ion-releasing dressing (Contreet) does not disturb angiogenesis and microvascularization in vivo. WOUNDS 2007; 19 (2): 39–45.
70. Kazmierski M, Mankowski P, Jankowski A, Harasymczuk J. Comparison of the results of operative and conservative treatment of deep dermal partial-thickness scalds in children. Eur J Pediatr Surg 2007; 17 (5): 354–61.
71. Paddock HN, Fabia R, Giles S et al. A silver-impregnated antimicrobial dressing reduces hospital costs for pediatric burn patients. J Pediatr Surg 2007; 42 (1): 211–3.
72. Lohsiriwat V, Chuangsuwanich A. Comparison of the ionic silver-containing hydrofiber and paraffin gauze dressing on split-thickness skin graft donor sites. Ann Plast Surg 2009; 62 (4): 421–2.
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А.Э.Бобровников, А.А.Алексеев 

1. ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2. ФГБУ «Национальный медицинский исследовательский центр хирургии им. А.В.Вишневского» Минздрава России, Москва, Россия

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Aleksandr E. Bobrovnikov, Andrey A. Alekseev

1. Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2. A.V.Vishnevsky National Medical Research Center of Surgery, Moscow, Russia