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Некротический (злокачественный) наружный отит: современный обзор диагностики и лечения
Некротический (злокачественный) наружный отит: современный обзор диагностики и лечения
Пчеленок Е.В., Косяков С.Я., Винников А.К. Некротический (злокачественный) наружный отит: современный обзор диагностики и лечения. Consilium Medicum. 2020; 22 (3): 70–73. DOI: 10.26442/20751753.2020.3.200021
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Аннотация
Проведен обзор современных принципов диагностики и лечения некротического наружного отита, который является редким заболеванием, однако по мере прогрессирования и при отсутствии адекватного лечения имеет тенденцию к распространению до костей основания черепа, что может привести к летальному исходу. В группу риска входят пожилые пациенты с сахарным диабетом и пациенты с различными иммунными нарушениями. Рассмотрены основные инфекционные агенты в развитии некротического наружного отита, основным из которых является синегнойная палочка. Представлены обязательные и дополнительные диагностические критерии, которыми необходимо руководствоваться при постановке диагноза.
В лечебной тактике основное место занимает антибиотикотерапия. Препаратами выбора являются фторхинолоны и цефалоспорины III поколения, при этом ученые до настоящего времени обсуждают длительность терапии, которая чаще всего составляет 6 нед. Дискутабельным остается вопрос о хирургическом лечении, освещены показания и результаты данного метода у пациентов с некротическим наружным отитом.
Ключевые слова: некротический наружный отит, сахарный диабет, злокачественный наружный отит.
Key words: necrotizing external otitis, diabetes mellitus, malignant external otitis.
В лечебной тактике основное место занимает антибиотикотерапия. Препаратами выбора являются фторхинолоны и цефалоспорины III поколения, при этом ученые до настоящего времени обсуждают длительность терапии, которая чаще всего составляет 6 нед. Дискутабельным остается вопрос о хирургическом лечении, освещены показания и результаты данного метода у пациентов с некротическим наружным отитом.
Ключевые слова: некротический наружный отит, сахарный диабет, злокачественный наружный отит.
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Key words: necrotizing external otitis, diabetes mellitus, malignant external otitis.
Полный текст
Список литературы
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[Arinova S.P. Nekroticheskii otit u bol'noi sakharnym diabetom. Meditsina i ekologiia. 2012; 2 (63): 131–2 (in Russian).].
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[Bobrov V.M. Nekroticheskii (zlokachestvennyi) naruzhnyi otit. Vestn. otolaringologii. 2011; 3: 71–2 (in Russian).].
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11. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
12. Lee SK, Lee SA, Seon SW et al. Analysis of Prognostic Factors in Malignant External Otitis. Clin Exp Otorhinolaryngol 2017; 10 (3): 228–35.
13. Phillips J, Jones S. Cochrane Database Syst Rev 2005: 18: CD004617.
14. Hobson CE, Moy JD, Byers KE. Malignant Otitis Externa: Evolving Pathogens and Implications for Diagnosis and Treatment. Otolaryngol Head Neck Surg 2014; 151 (1): 112–6.
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[Nikiforova G.N., Svistushkin V.M., Shevchik E.A., Zolotova A.V. Zlokachestvennyi naruzhnyi otit: sovremennye printsipy diagnostiki i lecheniia. Vestn. otolaringologii. 2017; 82 (1): 11–4 (in Russian).].
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25. Ress B, Luntz M, Telischi FF et al. Necrotizing External Otitis in patients with Aids. Laryngoscope 1997; 107 (4): 65–7.
26. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
27. Rowlands R, Lekakis G, Hinton A. Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsy. J Laryngol Otol 2002; 116 (7): 556–8.
28. Peleg U, Perez D, Raveh D et al. Stratification for malignant external otitis. Otolaryngol Head Neck Surg 2007; 137 (2): 301–5.
29. Cohen D, Friedman P. The diagnostic criteria of malignant external otitis. J Laryngol Otol 1987; 101 (3): 216–21.
30. Joshua B, Sulkes J, Raveh E et al. Predicting outcome of malignant external otitis. Otol Neurotol 2008; 29 (3): 339–43.
31. Sudhoff H, Rajagopal S, Mani N et al. Usefulness of CT scans in malignant external otitis: effective tool for the diagnosis, but of limited value in predicting outcome. Eur Arch Otorhinolaryngol 2008; 265 (1): 53–6.
32. Okpala N, Siraj QH, Nilssen E et al. Radiological and radionuclide investigation of malignant otitis externa. J Laryngol Otol 2005; 119 (1): 71–5.
33. Slattery W, Brackmann D. Skull base osteomyelitis: malignant otitis externa. Otolaryngol Clin North Am 1996; 29 (5): 795–806.
34. Grandis J, Branstetter B, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
35. Bhat V, Aziz A, Bhandary SK et al. Malignant Otitis Externa – A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. J Int Adv Otol 2015; 11 (1): 72–6.
36. Glikson E, Sagiv D, Wolf M et al. Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. Diagn Microbiol Infect Dis 2017; 87 (1): 74–8.
37. Chawdhary G, Pankhania M, Douglas S et al. Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. Acta Otolaryngol 2017; 137 (8): 818–22.
38. Pulcini C, Mahdyoun P, Cua E et al. Antibiotic therapy in necrotising external otitis: case series of 32 patients and review of the literature. Eur J Clin Microbiol Infect Dis 2012; 31 (12): 3287–94.
39. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing otitis externa: a systematic review. Otol Neurotol 2013; 34 (4): 620–9.
40. Jang C, Park S. Emergence of ciprofloxacin-resistant Pseudomonas in chronic suppurative otitis media. Clin Otolaryngol 2004; 29 (4): 321–3.
41. Jones M, Karlowsky JA, Draghi DC et al. Antibiotic susceptibility of bacteria most commonly isolated from bone related infections: the role of cephalosporins in antimicrobial therapy. Int J Antimicrob Agents 2004; 23 (3): 240–6.
42. Mardassi A, Turki S, Lahiani R et al. Is there a real benefit of hyperbaric oxygenotherapy in the treatment of necrotizing otitis externa? Tunis Med 2016; 94 (12): 863.
43. Orioli L, Boute C, Eloy P et al. Central skull base osteomyelitis: a rare but life-threatening disease. Acta Clin Belg 2015; 70 (4): 291–4.
44. Stodulski D, Kowalska B, Stankiewicz C. Otogenic skull base osteomyelitis caused by invasive fungal infection: case report and literature review. Eur Arch Otorhinolaryngol 2006; 263 (12): 1070–6.
45. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62 (3): 226–31.
46. Heiden C. Malignant otitis externa: experience with hyperbaric oxygen therapy. Diving Hyperb Med 2010; 40 (4): 182.
47. Bolton L. Hyperbaric Oxygen Therapy Effects on Chronic Wounds. Wounds 2015; 27 (12): 354–5.
48. Narozny W, Kuczkowski J, Stankiewicz C et al. Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment. Eur Arch Otorhinolaryngol 2006; 263 (7): 680–4.
49. Camporesi E. Side effects of hyperbaric oxygen therapy. Undersea Hyperb Med 2014; 41 (3): 253–7.
50. Illing E, Zolotar M, Ross E et al. Malignant otitis externa with skull base osteomyelitis. J Surg Case Rep 2011; 5: 6.
51. Sander R. Otitis externa: a practical guide to treatment and prevention. Am Fam Physician 2001; 63 (5): 941–2.
52. Foden N, Burgess C, Damato S et al. Concurrent necrotizing otitis externa and adenocarcinoma of the temporal bone: a diagnostic challenge. BMJ Case Rep 2013: 6.
53. Soudry E, Joshua BZ, Sulkes J et al. Characteristics and prognosis of malignant external otitis with facial paralysis. Arch Otolaryngol Head Neck Surg 2007; 133 (10): 1002–4.
54. Singh J, Bhardwaj B. The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa. Indian J Otolaryngol Head Neck Surg 2018; 70 (4): 549–54.
55. Hollis S, Evans K. Management of malignant (necrotising) otitis externa. J Laryngol Otol 2011; 125 (12): 1212–7.
2. Bhandary S, Karki P, Sinha B. Malignant otitis externa: a review. Pac Heal Dialog 2002; 9 (1): 64–7.
3. Meltzer P, Kelemen G. Pyocutaneous osteomyelitis of the temporal bone, mandible, and zygoma. Laryngoscope 1959; 169: 1300–16.
4. Chandler J. Malignant external otitis. Laryngoscope 1968; 78: 1257–94.
5. Mani N et al. Cranial nerve involvement in malignant otitis externa: implications for clinical outcome. Laryngoscope 2007; 117: 907–10.
6. Arinova S.P. Nekroticheskii otit u bol'noi sakharnym diabetom. Meditsina i ekologiia. 2012; 2 (63): 131–2 (in Russian).
7. Chawdhary G. Liow N, Democratis J et al. Necrotising (malignant) otitis externa in the UK: a growing problem. Review of five cases and analysis of national Hospital Episode Statistics trends. J Laryngol Otol 2015; 129 (6): 600–3.
8. Bovo R, Benatti A, Ciorba A et al. Pseudomonas and Aspergillus interaction in malignant external otitis: risk of treatment failure. Acta Otorhinolaryngol Ital 2012; 32 (6): 416–9.
9. Bobrov V.M. Nekroticheskii (zlokachestvennyi) naruzhnyi otit. Vestn. otolaringologii. 2011; 3: 71–2 (in Russian).
10. Sobie S, Brodsky L, Stanievich J. Necrotizing external otitis in children: report of two cases and review of the literature. Laryngoscope 1987; 97 (5): 598–601.
11. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
12. Lee SK, Lee SA, Seon SW et al. Analysis of Prognostic Factors in Malignant External Otitis. Clin Exp Otorhinolaryngol 2017; 10 (3): 228–35.
13. Phillips J, Jones S. Cochrane Database Syst Rev 2005: 18: CD004617.
14. Hobson CE, Moy JD, Byers KE. Malignant Otitis Externa: Evolving Pathogens and Implications for Diagnosis and Treatment. Otolaryngol Head Neck Surg 2014; 151 (1): 112–6.
15. Wyatt RJ, Alexander RC, Egan MF et al. Schizophrenia, just the facts. What do we know, how well do we know it? Schizophr Res 1988; 1: 3–18.
16. Rosenfeld R, Schwartz SR, Cannon SR et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg 2014; 150 (1l): 1–24.
17. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing Otitis Externa. Otol Neurotol 2013; 34 (4): 620–9.
18. Chen J, Yeh CF, Shiao AS et al. Temporal bone osteomyelitis: the relationship with malignant otitis externa, the diagnostic dilemma, and changing trends. Sci World J 2014; 591714.
19. Bovo R, Martini A, Agnoletto M et al. Pseudomonas and Aspergillus interaction in malignant external otitis: risk of treatment failure. Acta Otorhinolaryngol Ital 2012; 32 (6): 416–9.
20. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62: 226–33.
21. Rubin Grandis J, Branstetter Bf, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
22. Nikiforova G.N., Svistushkin V.M., Shevchik E.A., Zolotova A.V. Zlokachestvennyi naruzhnyi otit: sovremennye printsipy diagnostiki i lecheniia. Vestn. otolaringologii. 2017; 82 (1): 11–4 (in Russian).
23. Geerlings S, Hoepelman A. Immune dysfunction in patients with diabetes mellitus. Immunol Med Microbiol 1999; 26 (3): 259–65.
24. Kriukov A.I., Kunel'skaia N.L., Kunel'skaia V.Ia. Otomikoz: sovremennyi vzgliad na etiologiiu i lechenie. Vestn. otolaringologii. 2018; 83 (1): 48–51 (in Russian).
25. Ress B, Luntz M, Telischi FF et al. Necrotizing External Otitis in patients with Aids. Laryngoscope 1997; 107 (4): 65–7.
26. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
27. Rowlands R, Lekakis G, Hinton A. Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsy. J Laryngol Otol 2002; 116 (7): 556–8.
28. Peleg U, Perez D, Raveh D et al. Stratification for malignant external otitis. Otolaryngol Head Neck Surg 2007; 137 (2): 301–5.
29. Cohen D, Friedman P. The diagnostic criteria of malignant external otitis. J Laryngol Otol 1987; 101 (3): 216–21.
30. Joshua B, Sulkes J, Raveh E et al. Predicting outcome of malignant external otitis. Otol Neurotol 2008; 29 (3): 339–43.
31. Sudhoff H, Rajagopal S, Mani N et al. Usefulness of CT scans in malignant external otitis: effective tool for the diagnosis, but of limited value in predicting outcome. Eur Arch Otorhinolaryngol 2008; 265 (1): 53–6.
32. Okpala N, Siraj QH, Nilssen E et al. Radiological and radionuclide investigation of malignant otitis externa. J Laryngol Otol 2005; 119 (1): 71–5.
33. Slattery W, Brackmann D. Skull base osteomyelitis: malignant otitis externa. Otolaryngol Clin North Am 1996; 29 (5): 795–806.
34. Grandis J, Branstetter B, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
35. Bhat V, Aziz A, Bhandary SK et al. Malignant Otitis Externa – A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. J Int Adv Otol 2015; 11 (1): 72–6.
36. Glikson E, Sagiv D, Wolf M et al. Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. Diagn Microbiol Infect Dis 2017; 87 (1): 74–8.
37. Chawdhary G, Pankhania M, Douglas S et al. Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. Acta Otolaryngol 2017; 137 (8): 818–22.
38. Pulcini C, Mahdyoun P, Cua E et al. Antibiotic therapy in necrotising external otitis: case series of 32 patients and review of the literature. Eur J Clin Microbiol Infect Dis 2012; 31 (12): 3287–94.
39. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing otitis externa: a systematic review. Otol Neurotol 2013; 34 (4): 620–9.
40. Jang C, Park S. Emergence of ciprofloxacin-resistant Pseudomonas in chronic suppurative otitis media. Clin Otolaryngol 2004; 29 (4): 321–3.
41. Jones M, Karlowsky JA, Draghi DC et al. Antibiotic susceptibility of bacteria most commonly isolated from bone related infections: the role of cephalosporins in antimicrobial therapy. Int J Antimicrob Agents 2004; 23 (3): 240–6.
42. Mardassi A, Turki S, Lahiani R et al. Is there a real benefit of hyperbaric oxygenotherapy in the treatment of necrotizing otitis externa? Tunis Med 2016; 94 (12): 863.
43. Orioli L, Boute C, Eloy P et al. Central skull base osteomyelitis: a rare but life-threatening disease. Acta Clin Belg 2015; 70 (4): 291–4.
44. Stodulski D, Kowalska B, Stankiewicz C. Otogenic skull base osteomyelitis caused by invasive fungal infection: case report and literature review. Eur Arch Otorhinolaryngol 2006; 263 (12): 1070–6.
45. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62 (3): 226–31.
46. Heiden C. Malignant otitis externa: experience with hyperbaric oxygen therapy. Diving Hyperb Med 2010; 40 (4): 182.
47. Bolton L. Hyperbaric Oxygen Therapy Effects on Chronic Wounds. Wounds 2015; 27 (12): 354–5.
48. Narozny W, Kuczkowski J, Stankiewicz C et al. Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment. Eur Arch Otorhinolaryngol 2006; 263 (7): 680–4.
49. Camporesi E. Side effects of hyperbaric oxygen therapy. Undersea Hyperb Med 2014; 41 (3): 253–7.
50. Illing E, Zolotar M, Ross E et al. Malignant otitis externa with skull base osteomyelitis. J Surg Case Rep 2011; 5: 6.
51. Sander R. Otitis externa: a practical guide to treatment and prevention. Am Fam Physician 2001; 63 (5): 941–2.
52. Foden N, Burgess C, Damato S et al. Concurrent necrotizing otitis externa and adenocarcinoma of the temporal bone: a diagnostic challenge. BMJ Case Rep 2013: 6.
53. Soudry E, Joshua BZ, Sulkes J et al. Characteristics and prognosis of malignant external otitis with facial paralysis. Arch Otolaryngol Head Neck Surg 2007; 133 (10): 1002–4.
54. Singh J, Bhardwaj B. The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa. Indian J Otolaryngol Head Neck Surg 2018; 70 (4): 549–54.
55. Hollis S, Evans K. Management of malignant (necrotising) otitis externa. J Laryngol Otol 2011; 125 (12): 1212–7.
2. Bhandary S, Karki P, Sinha B. Malignant otitis externa: a review. Pac Heal Dialog 2002; 9 (1): 64–7.
3. Meltzer P, Kelemen G. Pyocutaneous osteomyelitis of the temporal bone, mandible, and zygoma. Laryngoscope 1959; 169: 1300–16.
4. Chandler J. Malignant external otitis. Laryngoscope 1968; 78: 1257–94.
5. Mani N et al. Cranial nerve involvement in malignant otitis externa: implications for clinical outcome. Laryngoscope 2007; 117: 907–10.
6. Аринова С.П. Некротический отит у больной сахарным диабетом. Медицина и экология. 2012; 2 (63): 131–2.
[Arinova S.P. Nekroticheskii otit u bol'noi sakharnym diabetom. Meditsina i ekologiia. 2012; 2 (63): 131–2 (in Russian).].
7. Chawdhary G. Liow N, Democratis J et al. Necrotising (malignant) otitis externa in the UK: a growing problem. Review of five cases and analysis of national Hospital Episode Statistics trends. J Laryngol Otol 2015; 129 (6): 600–3.
8. Bovo R, Benatti A, Ciorba A et al. Pseudomonas and Aspergillus interaction in malignant external otitis: risk of treatment failure. Acta Otorhinolaryngol Ital 2012; 32 (6): 416–9.
9. Бобров В.М. Некротический (злокачественный) наружный отит. Вестн. отоларингологии. 2011; 3: 71–2.
[Bobrov V.M. Nekroticheskii (zlokachestvennyi) naruzhnyi otit. Vestn. otolaringologii. 2011; 3: 71–2 (in Russian).].
10. Sobie S, Brodsky L, Stanievich J. Necrotizing external otitis in children: report of two cases and review of the literature. Laryngoscope 1987; 97 (5): 598–601.
11. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
12. Lee SK, Lee SA, Seon SW et al. Analysis of Prognostic Factors in Malignant External Otitis. Clin Exp Otorhinolaryngol 2017; 10 (3): 228–35.
13. Phillips J, Jones S. Cochrane Database Syst Rev 2005: 18: CD004617.
14. Hobson CE, Moy JD, Byers KE. Malignant Otitis Externa: Evolving Pathogens and Implications for Diagnosis and Treatment. Otolaryngol Head Neck Surg 2014; 151 (1): 112–6.
15. Wyatt RJ, Alexander RC, Egan MF et al. Schizophrenia, just the facts. What do we know, how well do we know it? Schizophr Res 1988; 1: 3–18.
16. Rosenfeld R, Schwartz SR, Cannon SR et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg 2014; 150 (1l): 1–24.
17. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing Otitis Externa. Otol Neurotol 2013; 34 (4): 620–9.
18. Chen J, Yeh CF, Shiao AS et al. Temporal bone osteomyelitis: the relationship with malignant otitis externa, the diagnostic dilemma, and changing trends. Sci World J 2014; 591714.
19. Bovo R, Martini A, Agnoletto M et al. Pseudomonas and Aspergillus interaction in malignant external otitis: risk of treatment failure. Acta Otorhinolaryngol Ital 2012; 32 (6): 416–9.
20. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62: 226–33.
21. Rubin Grandis J, Branstetter Bf, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
22. Никифорова Г.Н., Свистушкин В.М., Шевчик Е.А., Золотова А.В. Злокачественный наружный отит: современные принципы диагностики и лечения. Вестн. отоларингологии. 2017; 82 (1): 11–4.
[Nikiforova G.N., Svistushkin V.M., Shevchik E.A., Zolotova A.V. Zlokachestvennyi naruzhnyi otit: sovremennye printsipy diagnostiki i lecheniia. Vestn. otolaringologii. 2017; 82 (1): 11–4 (in Russian).].
23. Geerlings S, Hoepelman A. Immune dysfunction in patients with diabetes mellitus. Immunol Med Microbiol 1999; 26 (3): 259–65.
24. Крюков А.И., Кунельская Н.Л., Кунельская В.Я. Отомикоз: современный взгляд на этиологию и лечение. Вестн. отоларингологии. 2018; 83 (1): 48–51.
[Kriukov A.I., Kunel'skaia N.L., Kunel'skaia V.Ia. Otomikoz: sovremennyi vzgliad na etiologiiu i lechenie. Vestn. otolaringologii. 2018; 83 (1): 48–51 (in Russian).]
25. Ress B, Luntz M, Telischi FF et al. Necrotizing External Otitis in patients with Aids. Laryngoscope 1997; 107 (4): 65–7.
26. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
27. Rowlands R, Lekakis G, Hinton A. Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsy. J Laryngol Otol 2002; 116 (7): 556–8.
28. Peleg U, Perez D, Raveh D et al. Stratification for malignant external otitis. Otolaryngol Head Neck Surg 2007; 137 (2): 301–5.
29. Cohen D, Friedman P. The diagnostic criteria of malignant external otitis. J Laryngol Otol 1987; 101 (3): 216–21.
30. Joshua B, Sulkes J, Raveh E et al. Predicting outcome of malignant external otitis. Otol Neurotol 2008; 29 (3): 339–43.
31. Sudhoff H, Rajagopal S, Mani N et al. Usefulness of CT scans in malignant external otitis: effective tool for the diagnosis, but of limited value in predicting outcome. Eur Arch Otorhinolaryngol 2008; 265 (1): 53–6.
32. Okpala N, Siraj QH, Nilssen E et al. Radiological and radionuclide investigation of malignant otitis externa. J Laryngol Otol 2005; 119 (1): 71–5.
33. Slattery W, Brackmann D. Skull base osteomyelitis: malignant otitis externa. Otolaryngol Clin North Am 1996; 29 (5): 795–806.
34. Grandis J, Branstetter B, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
35. Bhat V, Aziz A, Bhandary SK et al. Malignant Otitis Externa – A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. J Int Adv Otol 2015; 11 (1): 72–6.
36. Glikson E, Sagiv D, Wolf M et al. Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. Diagn Microbiol Infect Dis 2017; 87 (1): 74–8.
37. Chawdhary G, Pankhania M, Douglas S et al. Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. Acta Otolaryngol 2017; 137 (8): 818–22.
38. Pulcini C, Mahdyoun P, Cua E et al. Antibiotic therapy in necrotising external otitis: case series of 32 patients and review of the literature. Eur J Clin Microbiol Infect Dis 2012; 31 (12): 3287–94.
39. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing otitis externa: a systematic review. Otol Neurotol 2013; 34 (4): 620–9.
40. Jang C, Park S. Emergence of ciprofloxacin-resistant Pseudomonas in chronic suppurative otitis media. Clin Otolaryngol 2004; 29 (4): 321–3.
41. Jones M, Karlowsky JA, Draghi DC et al. Antibiotic susceptibility of bacteria most commonly isolated from bone related infections: the role of cephalosporins in antimicrobial therapy. Int J Antimicrob Agents 2004; 23 (3): 240–6.
42. Mardassi A, Turki S, Lahiani R et al. Is there a real benefit of hyperbaric oxygenotherapy in the treatment of necrotizing otitis externa? Tunis Med 2016; 94 (12): 863.
43. Orioli L, Boute C, Eloy P et al. Central skull base osteomyelitis: a rare but life-threatening disease. Acta Clin Belg 2015; 70 (4): 291–4.
44. Stodulski D, Kowalska B, Stankiewicz C. Otogenic skull base osteomyelitis caused by invasive fungal infection: case report and literature review. Eur Arch Otorhinolaryngol 2006; 263 (12): 1070–6.
45. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62 (3): 226–31.
46. Heiden C. Malignant otitis externa: experience with hyperbaric oxygen therapy. Diving Hyperb Med 2010; 40 (4): 182.
47. Bolton L. Hyperbaric Oxygen Therapy Effects on Chronic Wounds. Wounds 2015; 27 (12): 354–5.
48. Narozny W, Kuczkowski J, Stankiewicz C et al. Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment. Eur Arch Otorhinolaryngol 2006; 263 (7): 680–4.
49. Camporesi E. Side effects of hyperbaric oxygen therapy. Undersea Hyperb Med 2014; 41 (3): 253–7.
50. Illing E, Zolotar M, Ross E et al. Malignant otitis externa with skull base osteomyelitis. J Surg Case Rep 2011; 5: 6.
51. Sander R. Otitis externa: a practical guide to treatment and prevention. Am Fam Physician 2001; 63 (5): 941–2.
52. Foden N, Burgess C, Damato S et al. Concurrent necrotizing otitis externa and adenocarcinoma of the temporal bone: a diagnostic challenge. BMJ Case Rep 2013: 6.
53. Soudry E, Joshua BZ, Sulkes J et al. Characteristics and prognosis of malignant external otitis with facial paralysis. Arch Otolaryngol Head Neck Surg 2007; 133 (10): 1002–4.
54. Singh J, Bhardwaj B. The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa. Indian J Otolaryngol Head Neck Surg 2018; 70 (4): 549–54.
55. Hollis S, Evans K. Management of malignant (necrotising) otitis externa. J Laryngol Otol 2011; 125 (12): 1212–7.
________________________________________________
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17. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing Otitis Externa. Otol Neurotol 2013; 34 (4): 620–9.
18. Chen J, Yeh CF, Shiao AS et al. Temporal bone osteomyelitis: the relationship with malignant otitis externa, the diagnostic dilemma, and changing trends. Sci World J 2014; 591714.
19. Bovo R, Martini A, Agnoletto M et al. Pseudomonas and Aspergillus interaction in malignant external otitis: risk of treatment failure. Acta Otorhinolaryngol Ital 2012; 32 (6): 416–9.
20. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62: 226–33.
21. Rubin Grandis J, Branstetter Bf, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
22. Nikiforova G.N., Svistushkin V.M., Shevchik E.A., Zolotova A.V. Zlokachestvennyi naruzhnyi otit: sovremennye printsipy diagnostiki i lecheniia. Vestn. otolaringologii. 2017; 82 (1): 11–4 (in Russian).
23. Geerlings S, Hoepelman A. Immune dysfunction in patients with diabetes mellitus. Immunol Med Microbiol 1999; 26 (3): 259–65.
24. Kriukov A.I., Kunel'skaia N.L., Kunel'skaia V.Ia. Otomikoz: sovremennyi vzgliad na etiologiiu i lechenie. Vestn. otolaringologii. 2018; 83 (1): 48–51 (in Russian).
25. Ress B, Luntz M, Telischi FF et al. Necrotizing External Otitis in patients with Aids. Laryngoscope 1997; 107 (4): 65–7.
26. Carfrae M, Kesser B. Malignant otitis externa. Otolaryngol Clin North Am 2008; 41 (3): 537–49.
27. Rowlands R, Lekakis G, Hinton A. Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsy. J Laryngol Otol 2002; 116 (7): 556–8.
28. Peleg U, Perez D, Raveh D et al. Stratification for malignant external otitis. Otolaryngol Head Neck Surg 2007; 137 (2): 301–5.
29. Cohen D, Friedman P. The diagnostic criteria of malignant external otitis. J Laryngol Otol 1987; 101 (3): 216–21.
30. Joshua B, Sulkes J, Raveh E et al. Predicting outcome of malignant external otitis. Otol Neurotol 2008; 29 (3): 339–43.
31. Sudhoff H, Rajagopal S, Mani N et al. Usefulness of CT scans in malignant external otitis: effective tool for the diagnosis, but of limited value in predicting outcome. Eur Arch Otorhinolaryngol 2008; 265 (1): 53–6.
32. Okpala N, Siraj QH, Nilssen E et al. Radiological and radionuclide investigation of malignant otitis externa. J Laryngol Otol 2005; 119 (1): 71–5.
33. Slattery W, Brackmann D. Skull base osteomyelitis: malignant otitis externa. Otolaryngol Clin North Am 1996; 29 (5): 795–806.
34. Grandis J, Branstetter B, Yu V. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004; 4 (1): 34–9.
35. Bhat V, Aziz A, Bhandary SK et al. Malignant Otitis Externa – A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. J Int Adv Otol 2015; 11 (1): 72–6.
36. Glikson E, Sagiv D, Wolf M et al. Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. Diagn Microbiol Infect Dis 2017; 87 (1): 74–8.
37. Chawdhary G, Pankhania M, Douglas S et al. Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. Acta Otolaryngol 2017; 137 (8): 818–22.
38. Pulcini C, Mahdyoun P, Cua E et al. Antibiotic therapy in necrotising external otitis: case series of 32 patients and review of the literature. Eur J Clin Microbiol Infect Dis 2012; 31 (12): 3287–94.
39. Mahdyoun P, Pulcini C, Gahide I et al. Necrotizing otitis externa: a systematic review. Otol Neurotol 2013; 34 (4): 620–9.
40. Jang C, Park S. Emergence of ciprofloxacin-resistant Pseudomonas in chronic suppurative otitis media. Clin Otolaryngol 2004; 29 (4): 321–3.
41. Jones M, Karlowsky JA, Draghi DC et al. Antibiotic susceptibility of bacteria most commonly isolated from bone related infections: the role of cephalosporins in antimicrobial therapy. Int J Antimicrob Agents 2004; 23 (3): 240–6.
42. Mardassi A, Turki S, Lahiani R et al. Is there a real benefit of hyperbaric oxygenotherapy in the treatment of necrotizing otitis externa? Tunis Med 2016; 94 (12): 863.
43. Orioli L, Boute C, Eloy P et al. Central skull base osteomyelitis: a rare but life-threatening disease. Acta Clin Belg 2015; 70 (4): 291–4.
44. Stodulski D, Kowalska B, Stankiewicz C. Otogenic skull base osteomyelitis caused by invasive fungal infection: case report and literature review. Eur Arch Otorhinolaryngol 2006; 263 (12): 1070–6.
45. Hamzany Y, Soudry E, Preis M. Fungal malignant external otitis. J Infect 2011; 62 (3): 226–31.
46. Heiden C. Malignant otitis externa: experience with hyperbaric oxygen therapy. Diving Hyperb Med 2010; 40 (4): 182.
47. Bolton L. Hyperbaric Oxygen Therapy Effects on Chronic Wounds. Wounds 2015; 27 (12): 354–5.
48. Narozny W, Kuczkowski J, Stankiewicz C et al. Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment. Eur Arch Otorhinolaryngol 2006; 263 (7): 680–4.
49. Camporesi E. Side effects of hyperbaric oxygen therapy. Undersea Hyperb Med 2014; 41 (3): 253–7.
50. Illing E, Zolotar M, Ross E et al. Malignant otitis externa with skull base osteomyelitis. J Surg Case Rep 2011; 5: 6.
51. Sander R. Otitis externa: a practical guide to treatment and prevention. Am Fam Physician 2001; 63 (5): 941–2.
52. Foden N, Burgess C, Damato S et al. Concurrent necrotizing otitis externa and adenocarcinoma of the temporal bone: a diagnostic challenge. BMJ Case Rep 2013: 6.
53. Soudry E, Joshua BZ, Sulkes J et al. Characteristics and prognosis of malignant external otitis with facial paralysis. Arch Otolaryngol Head Neck Surg 2007; 133 (10): 1002–4.
54. Singh J, Bhardwaj B. The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa. Indian J Otolaryngol Head Neck Surg 2018; 70 (4): 549–54.
55. Hollis S, Evans K. Management of malignant (necrotising) otitis externa. J Laryngol Otol 2011; 125 (12): 1212–7.
Авторы
Е.В. Пчеленок*, С.Я. Косяков, А.К. Винников
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*epchelenok@yandex.ru
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*epchelenok@yandex.ru
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*epchelenok@yandex.ru
________________________________________________
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*epchelenok@yandex.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.