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Роль и место нутрицевтиков в комплексной терапии идиопатического мужского бесплодия
Роль и место нутрицевтиков в комплексной терапии идиопатического мужского бесплодия
Макушин Д.Г., Белкина Л.В., Трухан Д.И. Роль и место нутрицевтиков в комплексной терапии идиопатического мужского бесплодия. Consilium Medicum. 2020; 22 (6): 50–57. DOI: 10.26442/20751753.2020.6.200254
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Аннотация
Бесплодие является глобальной проблемой, затрагивающей 15% сексуально активных традиционных супружеских пар во всем мире. В последнее время мужское бесплодие сравнялось по частоте с женским – частота «мужского» фактора в семейном бесплодии достигает 40–50% и продолжает увеличиваться. В 40–60% случаев имеется единственная аномалия – патологическая спермограмма, а при комплексном объективном и лабораторном исследовании других аномалий не определяется. Бесплодие с невыявленными причинами нарушения фертильности называют неуточненным, или идиопатическим. Применение нутрицевтиков или биологически активных добавок благодаря активным компонентам их состава представляет собой оправданный терапевтический подход к улучшению параметров спермы и мужской фертильности. В обзоре рассмотрено влияние различных компонентов нутрицевтиков – микроэлементов (цинк, селен), аминокислот (L-аргинин), витаминов (С, Е, В6, В12, D, фолиевая кислота, L-карнитин, убихинон), используемых в комплексной терапии мужского бесплодия. Все перечисленные выше активные компоненты нутрицевтиков, позитивно влияющие на мужскую фертильность, в том числе и витамин D3, входят в состав нутрицевтика Вирфертил®.
Ключевые слова: мужское бесплодие, идиопатическое мужское бесплодие, нутрицевтики, микроэлементы, витамины, холекальциферол, аминокислоты, Вирфертил.
Key words: male infertility, idiopathic male infertility, nutraceuticals, trace elements, vitamins, colecalciferol, amino acids, Virfertil.
Ключевые слова: мужское бесплодие, идиопатическое мужское бесплодие, нутрицевтики, микроэлементы, витамины, холекальциферол, аминокислоты, Вирфертил.
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Key words: male infertility, idiopathic male infertility, nutraceuticals, trace elements, vitamins, colecalciferol, amino acids, Virfertil.
Полный текст
Список литературы
1. WHO Manual for the Standardised Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press, 2000. https://www.who.int/reproductivehealth/publications/infertility/0521774748/en/
2. Examination and processing of human semen. World Health Organization: Geneva, Switzerland, 2010. https://link.springer.com/chapter/10.1007/978-1-4939-2140-9_3
3. Клинические рекомендации. Мужское бесплодие. 2019. Российское общество урологов. https://www.ooorou.ru/ru/page/rcr.html
[Clinical recommendations. Male infertility. 2019. Russian Society of Urology. https://www.ooorou.ru/ru/page/rcr.html (in Russian).]
4. Wong WY, Thomas CMG, Merkus JM et al. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril 2000; 73: 435–42. DOI: 10.1016/s0015-0282 (99)00551-8
5. Jungwirth A, Giwercman A, Tournaye H et al. European Association of Urology Guidelines on Male Infertility: The 2012 Update. Eur Urol 2012; 62 (2): 324–32. DOI: 10.1016/j.eururo.2012.04.048
6. Kopera IA, Bilinska B, Cheng CY, Mruk DD. Sertoli-germ cell junctions in the testis: a review of recent data. Philos Trans R Soc Lond B Biol Sci 2010; 365 (1546): 1593–605. DOI: 10.1098/rstb.2009.0251
7. Lie PP, Mruk DD, Lee WM et al. Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 365: 1581–92. DOI: 10.1098/rstb.2009.0261
8. Mital P, Hinton BT, Dufour JM. The blood-testis and blood-epididymis barriers are more than just their tight junctions. Biol Reprod 2011; 5: 851–8. DOI: 10.1095/biolreprod.110.087452
9. Корнеев И.А. Терапия мужского бесплодия: анализ исследований. Мед. совет. 2019; 13: 99–104. DOI: 10.21518/2079-701X-2019-13-99-104
[Korneev I.A. Male infertility treatments: clinical overview. Meditsinskiy sovet = Medical Council. 2019; 13: 99–104. DOI: 10.21518/2079-701X-2019-13-99-104 (in Russian).]
10. Черных В.Б., Соловова О.А. Мужское бесплодие: взгляд генетика на актуальную проблему. Consilium Medicum. 2019; 21 (7): 19–24. DOI: 10.26442/20751753.2019.7.190517
[Chernykh V.B., Solovova O.A. Male infertility: genetic focus on actual problem. Consilium Medicum. 2019; 21 (7): 19–24. DOI: 10.26442/20751753.2019.7.190517 (in Russian).]
11. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609–13. DOI: 10.1136/bmj.305.6854.609
12. World Health Organization. Laboratory manual for the examination and processing of human semen. 5rd ed. 2010. https://apps.who.int/iris/handle/10665/44261
13. Cooper TG, Noonan E, von Eckardstein S et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16 (3): 231–45. DOI: 10.1093/humupd/dmp048
14. Cao XW, Lin K, Li CY, Yuan CW. A review of WHO Laboratory Manual for the Examination and Processing of Human Semen (5th edition). Zhonghua Nan Ke Xue 2011; 17 (12): 1059–63. https://pubmed.ncbi.nlm.nih.gov/22235670/
15. Трухан Д.И., Макушин Д.Г. Роль и место антиоксидантов в комплексной терапии мужского бесплодия. Consilium Medicum. 2015; 17 (7): 37–43. https://www.elibrary.ru/item.asp?id=24394758
[Trukhan D.I., Makushin D.G. Role and position of antioxidants in complex therapy of male infertility. Consilium Medicum. 2015; 17 (7): 37–43. https://www.elibrary.ru/item.asp?id=24394758 (in Russian).]
16. Male infertility. Available at: https://pubmed.ncbi.nlm.nih.gov/?term=Male+infertility
17. Krausz C, Escamilla AR, Chianese C. Genetics of male infertility: from research to clinic. Reproduction 2015; 150 (5): 159–74. DOI: 10.1530/REP-15-0261
18. Гамидов С., Авакян А. Идиопатическое бесплодие у мужчин: эпидемиология, этиология, патогенез, лечение. Врач. 2013; 7: 2–4. https://www.elibrary.ru/item.asp?id=20205882
[Gamidov S., Avakyan A. Idiopathic male infertility: epidemiolofy, etiology, pathogenesis, treatment. Vrach. 2013; 7: 2–4. https://www.elibrary.ru/item.asp?id=20205882 (in Russian).]
19. Ősapay G, Ősapay K. Stress and Fertility. Orv Hetil 2015; 156 (35): 1430–4. DOI: 10.1556/650.2015.30250
20. De Celis R, Pedron-Nuevo N, Feria-Velasco A. Toxicology of male reproduction in animals and humans. Arch Androl 1996; 37: 201–18. DOI: 10.3109/01485019608988523
21. Hauser R. The environment and male fertility: recent research on emerging chemicals and semen quality. Semin Reprod Med 2006; 24 (3): 156–67. DOI: 10.1055/s-2006-944422
22. Зачепило А.В., Артифексов С.Б. Особенности этиологии и патогенеза нарушений функции мужской репродуктивной системы, обусловленных экологическими факторами. Проблемы репродукции. 2007; 4: 76–80. https://www.elibrary.ru/item.asp?id=13417751
[Zachepilo A.V., Artifeksov S.B. Osobennosti etiologii i patogeneza narushenij funkcii muzhskoj reproduktivnoj sistemy, obuslovlennyh ekologicheskimi faktorami. Problemy reprodukcii. 2007; 4: 76–80. https://www.elibrary.ru/item.asp?id=13417751 (in Russian).]
23. Агаджанян Н.А., Потемина Т.Е., Рыжаков Д.И. Нарушение мужской фертильности в условиях техногенного напряжения. Вестн. восстановительной медицины. 2007; 3: 87–90. https://www.elibrary.ru/item.asp?id=9563649
[Agadzhanyan N.A., Potemina T.E., Ryzhakov D.I. Narushenie muzhskoj fertil'nosti v usloviyah tekhnogennogo napryazheniya. Vestnik vosstanovitel'noj mediciny. 2007; 3: 87–90. https://www.elibrary.ru/item.asp?id=9563649 (in Russian).]
24. Meeker JD, Rossano MG, Protas B et al. Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant. Environ Health Perspect 2008; 116: 1473–9. DOI: 10.1289/ehp.11490
25. Calogero AE, La Vignera S, Condorelli RA et al. Environmental car exhaust pollution damages human sperm chromatin and DNA. J Endocrinol Invest 2011; 34 (6): 139–43. DOI: 10.1007/BF03346722
26. Oldereid NB, Thomassen Y, Purvis K. Seminal plasma lead, cadmium and zinc in relation to tobacco consumption. Int J Androl 1994; 17: 24–8. DOI: 10.1111/j.1365-2605.1994.tb01204.x
27. Lingappa HA, Govindashetty AM, Puttaveerachary AK et al. Evaluation of Effect of Cigarette Smoking on Vital Seminal Parameters which Influence Fertility. J Clin Diagn Res 2015; 9 (7): 13–5. DOI: 10.7860/JCDR/2015/13295.6227
28. Тюзиков И.А. Метаболический синдром и мужское бесплодие (обзор литературы). Андрология и генитальная хирургия. 2013; 2: 5–10. https://www.elibrary.ru/item.asp?id=21014760
[Tyuzikov I.A. Metabolic syndrome and male infertility (review) Andrologiya i genital'naya hirurgiya. 2013; 2: 5–10. https://www.elibrary.ru/item.asp?id=21014760 (in Russian).]
29. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online 2015; 31 (5): 593–604. DOI: 10.1016/j.rbmo.2015.07.012
30. Трухан Д.И., Викторова И.А. Нефрология. Эндокринология. Гематология. СПб.: СпецЛит, 2017. https://fictionbook.ru/author/d_i_truhan/nefrologiya_yendokrinologiya_gematologiya/
[Trukhan D.I., Viktorova I.A. Nefrologija. Jendokrinologija. Gematologija. Saint Petersburg: SpecLit, 2017. https://fictionbook.ru/author/d_i_truhan/nefrologiya_yendokrinologiya_gematologiya/ (in Russian).]
31. Agarwal A, Prabakaran SA, Said TM. Prevention of oxidative stress injury to sperm. J Androl 2005; 26 (6): 654–60. DOI: 10.2164/jandrol.05016
32. Brody S.A. Мужское бесплодие и окислительный стресс: роль диеты, образа жизни и пищевых добавок. Андрология и генитальная хирургия. 2014; 3: 33–41. https://www.elibrary.ru/
item.asp?id=22010097
[Brody S.A. Male factor infertility and oxidative stress: role of diet, lifestyle and nutritional supplements Andrologiya i genital'naya hirurgiya. 2014; 3: 33–41. https://www.elibrary.ru/
item.asp?id=22010097 (in Russian).]
33. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol 2004; 2: 12. DOI: 10.1186/1477-7827-2-12
34. Cavallini G. Male idiopathic oligoasthenoteratozoospermia. Asian J Androl 2006; 8: 143–57. DOI: 10.1111/j.1745-7262.2006.00123.x
35. Божедомов В.А., Громенко Д.С., Ушакова И.В. и др. Оксидативный стресс сперматозоидов в патогенезе мужского бесплодия. Урология. 2009; 2: 51–6. https://www.elibrary.ru/
item.asp?id=12869861
[Bozhedomov V.A., Gromenko D.S., Ushakova I.V. et al. Oxidative stress of spermatozoa in pathogenesis of male infertility. Urology. 2009; 2: 51–6. https://www.elibrary.ru/item.asp?id=12869861 (in Russian).]
36. Aitken RJ, De Iuliis GN, McLachlan RI. Biological and clinical significance of DNA damage in the male germ line. Int J Androl 2009; 32: 46–56. DOI: 10.1111/j.1365-2605.2008.00943.x
37. Божедомов В.А., Николаева М.А., Ушакова И.В. и др. Роль процессов свободно-радикального окисления в патогенезе мужского иммунного бесплодия. Андрология и генитальная хирургия. 2010; 4: 62–6. https://www.elibrary.ru/item.asp?id=15488663
[Bojedomov V.A., Nikolaeva М.А., Ushakova I.V. et. al. Role of free-radical oxidation process in male immune infertility pathogenesis. Rol' processov svobodno-radikal'nogo okisleniya v patogeneze muzhskogo immunnogo besplodiya. Andrologiya i genital'naya hirurgiya. 2010; 4: 62–6. https://www.elibrary.ru/item.asp?id=15488663 (in Russian).]
38. Ménézo Y, Entezami F, Lichtblau I et al. Oxidative stress and fertility: false evidence and bad recipes. Gynecol Obstet Fertil 2012; 40 (12): 787–96. DOI: 10.1016/j.gyobfe.2012.09.032
39. Kumar R, Gautam G, Gupta MP. Drug Therapy for Idiopathic Male Infertility: Rationale Versus Evidence. J Urol 2006; 176: 1307–12. DOI: 10.1016/j.juro.2006.06.006
40. Showell MG, Mackenzie-Proctor R, Brown J et al. Antioxidants for male subfertility. Cochrane Database Syst Rev 2014; 12: CD007411. DOI: 10.1002/14651858.CD007411.pub3
41. Eisenberg ML, Lipshultz LI. Varicocele-induced infertility: Newer insights into its pathophysiology. Indian J Urol 2011; 1: 58–64. DOI: 10.4103/0970-1591.78428
42. Sarkar O, Bahrainwala J, Chandrasekaran S et al. Impact of inflammation on male fertility. Front Biosci (Elite ed.) 2011; 3: 89–95. DOI: 10.2741/e223
43. Жуков О.Б., Евдокимов В.В., Жуков А.А. и др. Профессиональное медицинское сопровождение супружеской пары при бесплодии: современный подход. Consilium Medicum. 2013; 15 (7): 38–43. https://www.elibrary.ru/item.asp?id=20267649
[Zhukov O.B., Evdokimov V.V., Zhukov A.A. et al. Professional'noe meditsinskoe soprovozhdenie supruzheskoi pary pri besplodii: sovremennyi podkhod. Consilium Medicum. 2013; 15 (7): 38–43. https://www.elibrary.ru/item.asp?id=20267649 (in Russian).]
44. Abad C, Amengual MJ, Gosálvez J et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013; 45 (3): 211–6. DOI: 10.1111/and.12003
45. Ефремов Е.А., Касатонова Е.В., Мельник Я.И. Подготовка мужчины к зачатию. Урология. 2015; 3: 97–104. https://www.elibrary.ru/item.asp?id=23766606
[Efremov E.A., Kasatonova E.V., Mel'nik Ja.I. Male preconception care. Urologiya. 2015; 3: 97–104. https://www.elibrary.ru/item.asp?id=23766606 (in Russian).]
46. Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. Clin Invest 2003; 111 (5): 583–93. DOI: 10.1172/JCI18022
47. Трухан Д.И. Путешествие в лабиринте БАД. Московские аптеки. 2006; 9 (153). https://www.mosapteki.ru/modules/articles/article.php?id=447
[Trukhan D.I. Puteshestvie v labirinte BAD. Moskovskie apteki. 2006; 9 (153). https://www.mosapteki.ru/modules/articles/article.php?id=447 (in Russian).]
48. Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med 1980; 96: 544–50. https://pubmed.ncbi.nlm.nih.gov/6772723/
49. Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl 1981; 7: 69–73. DOI: 10.3109/01485018109009378
50. Kruczynski D, Passia D, Haider SG, Glassmeyer M. Zinc transport through residual bodies in the rat testis; a histochemical study. Andrologia 1985; 17: 98–103. DOI: 10.1111/j.1439-0272.1985.tb00967.x
51. Miura T, Yamauchi K, Takahashi H, Nagahama Y. Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese Eel (Anguilla japonica). Proc Natl Acad Sci USA 1991; 88: 5774–8. DOI: 10.1073/pnas.88.13.5774
52. Favier AE. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res 1992; 32: 363–82. DOI: 10.1007/BF02784623
53. Prasad AS. Zinc: an overview. Nutrition 1995; 11: 93–9. https://pubmed.ncbi.nlm.nih.gov/7749260/
54. Merker HJ, Günther T. Testis damage induced by zinc deficiency in rat. J Trace Element 1997; 11: 19–22. DOI: 10.1016/S0946-672X (97)80004-1
55. Prasad AS. Zinc deficiency. British Med J 2008; 326: 409–10. DOI: 10.1136/bmj.326.7386.409
56. Jalali GR, Roozbeh J et al. Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis. Ren Fail 2010; 32 (4): 417–9. DOI: 10.3109/08860221003706958
57. Сивков А.В., Ощепков В.Н., Кешишев Н.Г. и др. Роль селена и цинка при нарушениях фертильности у мужчин. Урология. 2009; 6: 59–62. https://www.elibrary.ru/
item.asp?id=13216440
[Sivkov A.V., Oshchepkov V.N., Keshishev N.G. et al. Rol' selena i cinka pri narusheniyah fertil'nosti u muzhchin. Urologiya. 2009; 6: 59–62. https://www.elibrary.ru/item.asp?id=13216440 (in Russian).]
58. Неймарк А.И., Клепикова И.И. Применение препарата Селцинк плюс у мужчин с нарушением фертильности. Андрология и генитальная хирургия. 2013; 4: 77–80. https://www.elibrary.ru/item.asp?id=21149905
[Neymark A.I., Klepikova I.I. Use of the drug selzinc plus in men with impaired fertility. Andrologiya i genital'naya hirurgiya. 2013; 4: 77–80. https://www.elibrary.ru/item.asp?id=21149905 (in Russian).]
59. Сивков А.В., Ощепков В.Н., Евдокимов В.В. и др. Эффективность и безопасность препарата Селцинк плюс у пациентов с хроническим неинфекционным простатитом и нарушениями фертильности. Consilium Medicum. 2011; 13 (7): 5–9. https://www.elibrary.ru/item.asp?id=20226024
[Sivkov A.V., Oshchepkov V.N., Evdokimov V.V. et al. Effektivnost' i bezopasnost' preparata Seltsink plius u patsientov s khronicheskim neinfektsionnym prostatitom i narusheniiami fertil'nosti. Consilium Medicum. 2011; 13 (7): 5–9. https://www.elibrary.ru/item.asp?id=20226024 (in Russian).]
60. Bunk MJ, Dnistrian AM, Schwartz MK, Rivlin RS. Dietary Zn deficiency decreases plasma concentrations of vitamin E. Proc Soc Exp Biol Med 1989; 190: 379–84. DOI: 10.3181/00379727-190-42876
61. Bieri JG. Effect of excessive vitamins C and E on vitamin A status. Am J Clin Nutr 1973; 26 (4): 382–3. DOI: 10.1093/ajcn/26.4.382
62. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
63. Scott R, MacPherson A, Yates RW et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998; 82: 76–80. DOI: 10.1046/j.1464-410x.1998.00683.x
64. Vezina D, Mauffette F, Roberts KD, Bleau G. Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res 1996; 53: 65–83. DOI: 10.1007/BF02784546
65. Keskes-Ammar L, Feki-Chakroun N, Rebai T et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 2003; 49 (2): 83–94. DOI: 10.1080/01485010390129269
66. Eroglu M, Sahin S, Durukan B. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme Q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res 2014; 159 (1–3): 46–51. DOI: 10.1007/s12011-014-9978-7
67. Patrick L. Selenium biochemistry and cancer: review of the literature. Altern Med Rev 2004; 9: 239–58. https://pubmed.ncbi.nlm.nih.gov/15387717/
68. Гриневич В.Б., Губонина И.В., Дощицин В.Л. и др. Особенности ведения коморбидных пациентов в период пандемии новой коронавирусной инфекции (COVID-19). Национальный Консенсус 2020. Кардиоваскулярная терапия и профилактика. 2020; 19 (4): 2630. doi: 10.15829/1728-8800-2020-2630
[Grinevich V. B., Gubonina I. V., Doshchitsin V. L. et. al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020; 19 (4): 2630. DOI: 10.15829/1728-88002020-2630 (in Russian).]
69. Fraga CG, Motchnik PA, Shigenaga MK et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA 1991; 88 (24): 11003–6. DOI: 10.1073/pnas.88.24.11003
70. Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992; 58: 1034–9. https://pubmed.ncbi.nlm.nih.gov/1426355/
71. Harris WA, Harden TE, Dawson EB. Apparent effect of ascorbic acid medication on semen metal levels. Fertil Steril 1979; 32 (4): 455–9. DOI: 10.1016/s0015-0282 (16)44304-9
72. Eskenazi B, Kidd SA, Marks AR et al. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 2005; 20 (4): 1006–12. DOI: 10.1093/humrep/deh725
73. Kessopoulou E, Powers HJ, Sharma KK et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil Steril 1995; 64: 825–31. DOI: 10.1016/s0015-0282 (16)57861-3
74. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
75. Momeni HR, Eskandari N. Effect of vitamin E on sperm parameters and DNA integrity in sodium arsenite-treated rats. Iran J Reprod Med 2012; 10 (3): 249–56. https://pubmed.ncbi.nlm.nih.gov/
25243001/
76. Ключников С.О. Коэнзим Q10. Перспективы клинического применения. Педиатрия. Приложение к журналу Consilium Medicum. 2014; 16 (3): 84–8. https://www.elibrary.ru/
item.asp?id=22514383
[Kliuchnikov S.O. Koenzim Q10. Perspektivy klinicheskogo primeneniia. Pediatrics. Consilium Medicum. 2014; 16 (3): 84–8. https://www.elibrary.ru/item.asp?id=22514383 (in Russian).]
77. Wang Y, Hekimi S. The Complexity of Making Ubiquinone. Trends Endocrinol Metab. 2019; 30 (12): 929–43. DOI: 10.1016/j.tem.2019.08.009
78. Beyer RE. The analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Bioche Cell Biol 1998; 70: 390–403. DOI: 10.1139/o92-061
79. Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10 implications in male infertility: biochemical and therapeutic aspects. Biofactors 2005; 25: 165–74. DOI: 10.1002/biof.5520250119
80. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007; 37: 31–7. DOI: 10.1007/s12033-007-0052-y
81. Mancini A, Milardi D, Conte G. Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Horm Metab Res 2005; 37 (7): 428–32. DOI: 10.1055/s-2005-870232
82. Cervellione RM, Cervato G, Zampieri N. Effect of varicocelectomy on the plasma oxidative stress parameters. J Pediatr Surg 2006; 41 (2): 403–6. DOI: 10.1016/j.jpedsurg.2005.11.018
83. Balercia G, Mancini A. Paggi F et al. Coenzyme Q10 and male infertility. J Endocrinol Invest 2009; 32: 626–32. DOI: 10.1007/BF03346521
84. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind., placebo controlled., randomized study. J Urol 2012; 188 (2): 526–31. DOI: 10.1016/j.juro.2012.03.131
85. Галимова Э.Ф. Механизмы протективного действия коэнзима Q10 при мужском бесплодии. Дальневосточный мед. журн. 2013; 3: 40–2. https://www.elibrary.ru/item.asp?id=20376359
[Galimova E.F. Mechanisms of the protective action of coenzyme q10 in male infertility. Dal'nevostochnyj med. zhurn. 2013; 3: 40–2. https://www.elibrary.ru/item.asp?id=20376359 (in Russian).]
86. Banihani SA. A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. Urol J 2017: 1–5. DOI: 10.22037/uj.v0i0.3808
87. Ebisch IM, Thomas CM, Peters WH et al. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007; 13 (2): 163–74. DOI: 10.1093/humupd/dml054
88. Трухан Д.И. Роль и место L-карнитина в цитопротекции и коррекции метаболических процессов у пациентов с метаболическим синдромом. Мед. совет. 2017; (12): 182–7. https://doi.org/10.21518/2079-701X-2017-12-182-187
[Trukhan D.I. Role and location of L-carnitine in cytoprotection and correction of metabolic processes in patients with metabolic syndrome. Meditsinskiy sovet = Medical Council. 2017; (12): 182–7. https://doi.org/10.21518/2079-701X-2017-12-182-187 (in Russian).]
89. Павлов В.Н., Галимова Э.Ф., Катаев В.А. и др. Сравнительный анализ антиоксидантных эффектов коэнзима Q и L-карнитина у мужчин с идиопатической патоспермией. Мед. вестн. Башкортостана. 2013; 6: 161–3. https://www.elibrary.ru/item.asp?id=20523092
[Pavlov V.N., Galimova E.F., Kataev V.A. et al. The comparative analysis of coenzyme q and l-carnitine antioxidant effects in men with idiopathic pathospermia. Med. vestn. Bashkortostana. 2013; 6: 161–3. https://www.elibrary.ru/item.asp?id=20523092 (in Russian).]
90. Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl 1992; 64: 187–96. https://pubmed.ncbi.nlm.nih.gov/1509274/
91. Costa M, Canale D, Filicori M et al. L-carnitine in idiopathic astheno-zoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia 1994; 26: 155–9. https://pubmed.ncbi.nlm.nih.gov/8085668/
92. Lenzi A, Sgro P, Salacone P et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1574–8. DOI: 10.1016/j.fertnstert.2003.10.034
93. Abd-Allah AR, Helal GK, Al-Yahya AA. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. Oxid Med Cell Longev 2009; 2: 73–81. DOI: 10.4161/oxim.2.2.8177
94. Виноградов И.В., Блохин А.В., Афанасьева Л.М. Опыт применения L-карнитина в лечении секреторного бесплодия у мужчин (обзор литературы). Андрология и генитальная хирургия. 2009; 2: 19–22. https://www.elibrary.ru/item.asp?id=12838097
[Vinogradov I.V., Blokhin A.V., Afanaseva L.M. et al. Usage of L-carnitine in the treatment of the male infertility (a review). Andrologiya i genital'naya hirurgiya. 2009; 2: 19–22. https://www.elibrary.ru/item.asp?id=12838097 (in Russian).]
95. Фесенко В.Н., Михайличенко В.В., Новиков А.И., Фесенко С.В. Оценка влияния L-карнитина тартрата на репродуктивную мужчин фертильного возраста. Проблемы репродукции. 2011; 6: 63–5. https://www.elibrary.ru/item.asp?id=18948758
[Fesenko V.N., Mikhaĭlichenko V.V., Novikov A.I., Fesenko S.V. The influence of L-carnitine tartrate of male reproductive function in fertile age. Problemy reprodukcii. 2011; 6: 63–5. https://www.elibrary.ru/item.asp?id=18948758 (in Russian).]
96. Галимов Ш.Н., Громенко Д.С., Галимова Э.Ф. и др. Влияние L-карнитина на показатели эякулята у мужчин у бесплодных пар. Урология. 2012; 1: 47–51. https://www.elibrary.ru/
item.asp?id=17706085
[Galimov Sh.N., Gromenko D.S., Galimova E.F. et al. Effects of L-carnitine on ejaculate parameters in males from infertile couples. Urologiya. 2012; 1: 47–51. https://www.elibrary.ru/
item.asp?id=17706085 (in Russian).]
97. Тюзиков И.А., Калинченко С.Ю., Ворслов Л.О., Греков Е.А. Оптимизация клинического применения комплекса L-карнитина и ацетил-L-карнитина в современной фармакотерапии идиопатического мужского бесплодия. Эффективная фармакотерапия. 2013; 1: 44–9. https://www.elibrary.ru/item.asp?id=22267188
[Tyuzikov I.A., Kalinchenko S.Yu., Vorslov L.O., Grekov E.A. Optimizaciya klinicheskogo primeneniya kompleksa L-karnitina i acetil-L-karnitina v sovremennoj farmakoterapii idiopaticheskogo muzhskogo besplodiya. Effektivnaya farmakoterapiya. 2013; 1: 44–9. https://www.elibrary.ru/
item.asp?id=22267188 (in Russian).]
98. Иванов Н.В., Ворохобина Н.В. Изучение влияния ацетил-L-карнитина на основные параметры эякулята у мужчин с идиопатической астенозооспермией. Проблемы репродукции. 2014; 1: 74–6. https://www.elibrary.ru/item.asp?id=21369825
[Ivanov N.V., Vorohobina N.V. Izuchenie vliyaniya acetil-L-karnitina na osnovnye parametry eyakulyata u muzhchin s idiopaticheskoj astenozoospermiej. Problemy reprodukcii. 2014; 1: 74–6. https://www.elibrary.ru/item.asp?id=21369825 (in Russian).]
99. Banihani SA. Vitamin B (12) and Semen Quality. Biomolecules. 2017; 7 (2): 42. DOI: 10.3390/biom7020042
100. Qi YN, Ma J, Han RY et.al. Correlation of the levels of seminal plasma homocysteine, folate and cobalamin with semen parameters in obese men. Zhonghua Nan Ke Xue 2018; 24 (10): 883–6. https://pubmed.ncbi.nlm.nih.gov/32212442/
101. Шварц Г.Я. Типы дефицита витамина D и их фармакологическая коррекция. Лекарственные средства. 2011; 2 (3): 33–42. https://www.elibrary.ru/item.asp?id=21104467
[Shvarts G.Ya. Types of Vitamin D Deficiency and Their Pharmacological Correction. Lekarstvennye sredstva. 2011; 2 (3): 33–42. https://www.elibrary.ru/item.asp?id=21104467 (in Russian).]
102. Cashman KD, Dowling KG, Škrabáková Z et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103 (4): 1033–44. DOI: 10.3945/ajcn.115.120873
103. Громова О.А. Витамин D и его синергисты. Лекция. Consilium Medicum. Педиатрия. 2015; 1: 14–9. https://www.elibrary.ru/item.asp?id=23414484
[Gromova O.A. Vitamin D and its synergists. Lecture. Pediatrics. Consilium Medicum. 2015; 1: 14–9. https://www.elibrary.ru/item.asp?id=23414484 (in Russian).]
104. Трухан Д.И. Остеопороз. Клинико-диагностические подходы на амбулаторно-поликлиническом этапе. Справочник поликлинического врача. 2016; 2: 14–7. https://www.elibrary.ru/
item.asp?id=26183328
[Trukhan D.I. Osteoporosis. Clinical and diagnostic approaches at the outpatient stage. Spravochnik poliklinicheskogo vracha. 2016; 02: 14-7. https://www.elibrary.ru/item.asp?id=26183328 (in Russian).]
105. Fu L, Chen YH, Xu S et al. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reprod Toxicol 2017; 73: 241–9. doi: 10.1016/j.reprotox.2017.06.047
106. Jeremy M, Gurusubramanian G, Roy VK. Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. J Steroid Biochem Mol Biol 2019; 190: 64–75. doi: 10.1016/j.jsbmb.2019.03.016
107. Zhu CL, Xu QF, Li SX et al. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia 2016; 48 (10): 1261–6. DOI: 10.1111/and.12570
108. Abbasihormozi S, Kouhkan A, Alizadeh AR et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5 (1): 113–8. DOI: 10.1111/andr.12280
109. Jensen BM, Bjerrum PJ, Jessen TE et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26 (6): 1307–17. DOI: 10.1093/humrep/der059
110. Jensen BM, Lawaetz JG, Petersen JH et al. Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial. J Clin Endocrinol Metab 2018; 103 (3): 870–81. DOI: 10.1210/jc.2017-01656
111. Dabrowski FA, Grzechocinska B, Wielgos M. The role of vitamin D in reproductive health – a Trojan Horse or the Golden Fleece? Nutrients 2015; 7 (6): 4139–53. DOI: 10.3390/nu7064139
112. Scibona M, Meschini P, Capparelli S et al. L-arginine and male infertility. Minerva Urol Nefrol 1994; 46 (4): 251–3. https://pubmed.ncbi.nlm.nih.gov/7701414/
113. Ma P, Zhang Z, Zhou X et al. Characterizing semen abnormality male infertility using non-targeted blood plasma metabolomics. PLoS One 2019; 14 (7): e0219179. DOI: 10.1371
/journal.pone.0219179
114. Kaya OS, Kandemir FM, Gur S et al. Evaluation of the role of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities in rams. Andrologia 2020; 52 (1): e13439. DOI: 10.1111/and.13439
115. Melik Z, Zaletel P, Virtic T, Cankar K. L-arginine as dietary supplement for improving microvascular function. Clin Hemorheol Microcirc 2017; 65 (3): 205–17. DOI: 10.3233/CH-16159
116. El Taieb M, Hegazy E, Ibrahim A. Daily Oral l-Arginine Plus Tadalafil in Diabetic Patients with Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial. J Sex Med 2019; 16 (9): 1390–7. DOI: 10.1016/j.jsxm.2019.06.009
117. Abd-Elrazek AM, Ahmed-Farid OAH. Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. Andrologia 2018; 50 (1). DOI: 10.1111/and.12806
118. Mirhafez SR, Hariri M. L-arginine effect on inflammatory mediators: A systematic review of randomized controlled clinical trials. Int J Vitam Nutr Res 2019. DOI: 10.1024/0300-9831/a000619
119. Smits MR, Mackenzie-Proctor R, Yazdani A et al. Antioxidants for Male Subfertility. Cochrane Database Syst Rev 2019; 3 (3): CD007411. DOI: 10.1002/14651858.CD007411.pub4
120. Garolla A, Petre GC, Francini-Pesenti F et al. Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition. Nutrients 2020; 12 (5): 1472. DOI: 10.3390/nu12051472
121. Филиппова О.В. Антиоксиданты как способ повышения мужской фертильности. Эффективная фармакотерапия. 2020; 3: 26–32. DOI: 10.33978/2307-3586-2020-16-3-26-32
[Filippova O.V. Antioxidants as a way to increase male fertility Effective pharmacotherapy. 2020; 3: 26–32. DOI: 10.33978/2307-3586-2020-16-3-26-32 (in Russian).]
0521774748/en/
2. Examination and processing of human semen. World Health Organization: Geneva, Switzerland, 2010. https://link.springer.com/chapter/10.1007/978-1-4939-2140-9_3
3. Clinical recommendations. Male infertility. 2019. Russian Society of Urology. https://www.ooorou.ru/ru/page/rcr.html (in Russian).
4. Wong WY, Thomas CMG, Merkus JM et al. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril 2000; 73: 435–42. DOI: 10.1016/s0015-0282 (99)00551-8
5. Jungwirth A, Giwercman A, Tournaye H et al. European Association of Urology Guidelines on Male Infertility: The 2012 Update. Eur Urol 2012; 62 (2): 324–32. DOI: 10.1016/j.eururo.2012.04.048
6. Kopera IA, Bilinska B, Cheng CY, Mruk DD. Sertoli-germ cell junctions in the testis: a review of recent data. Philos Trans R Soc Lond B Biol Sci 2010; 365 (1546): 1593–605. DOI: 10.1098/rstb.2009.0251
7. Lie PP, Mruk DD, Lee WM et al. Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 365: 1581–92. DOI: 10.1098/rstb.2009.0261
8. Mital P, Hinton BT, Dufour JM. The blood-testis and blood-epididymis barriers are more than just their tight junctions. Biol Reprod 2011; 5: 851–8. DOI: 10.1095/biolreprod.110.087452
9. Korneev I.A. Male infertility treatments: clinical overview. Meditsinskiy sovet = Medical Council. 2019; 13: 99–104. DOI: 10.21518/2079-701X-2019-13-99-104 (in Russian).
10. Chernykh V.B., Solovova O.A. Male infertility: genetic focus on actual problem. Consilium Medicum. 2019; 21 (7): 19–24. DOI: 10.26442/20751753.2019.7.190517 (in Russian).
11. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609–13. DOI: 10.1136/bmj.305.6854.609
12. World Health Organization. Laboratory manual for the examination and processing of human semen. 5rd ed. 2010. https://apps.who.int/iris/handle/10665/44261
13. Cooper TG, Noonan E, von Eckardstein S et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16 (3): 231–45. DOI: 10.1093/humupd/dmp048
14. Cao XW, Lin K, Li CY, Yuan CW. A review of WHO Laboratory Manual for the Examination and Processing of Human Semen (5th edition). Zhonghua Nan Ke Xue 2011; 17 (12): 1059–63. https://pubmed.ncbi.nlm.nih.gov/22235670/
15. Trukhan D.I., Makushin D.G. Role and position of antioxidants in complex therapy of male infertility. Consilium Medicum. 2015; 17 (7): 37–43. https://www.elibrary.ru/item.asp?id=24394758 (in Russian).
16. Male infertility. Available at: https://pubmed.ncbi.nlm.nih.gov/?term=Male+infertility
17. Krausz C, Escamilla AR, Chianese C. Genetics of male infertility: from research to clinic. Reproduction 2015; 150 (5): 159–74. DOI: 10.1530/REP-15-0261
18. Gamidov S., Avakyan A. Idiopathic male infertility: epidemiolofy, etiology, pathogenesis, treatment. Vrach. 2013; 7: 2–4. https://www.elibrary.ru/item.asp?id=20205882 (in Russian).
19. Ősapay G, Ősapay K. Stress and Fertility. Orv Hetil 2015; 156 (35): 1430–4. DOI: 10.1556/650.2015.30250
20. De Celis R, Pedron-Nuevo N, Feria-Velasco A. Toxicology of male reproduction in animals and humans. Arch Androl 1996; 37: 201–18. DOI: 10.3109/01485019608988523
21. Hauser R. The environment and male fertility: recent research on emerging chemicals and semen quality. Semin Reprod Med 2006; 24 (3): 156–67. DOI: 10.1055/s-2006-944422
22. Zachepilo A.V., Artifeksov S.B. Osobennosti etiologii i patogeneza narushenij funkcii muzhskoj reproduktivnoj sistemy, obuslovlennyh ekologicheskimi faktorami. Problemy reprodukcii. 2007; 4: 76–80. https://www.elibrary.ru/item.asp?id=13417751 (in Russian).
23. Agadzhanyan N.A., Potemina T.E., Ryzhakov D.I. Narushenie muzhskoj fertil'nosti v usloviyah tekhnogennogo napryazheniya. Vestnik vosstanovitel'noj mediciny. 2007; 3: 87–90. https://www.elibrary.ru/item.asp?id=9563649 (in Russian).
24. Meeker JD, Rossano MG, Protas B et al. Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant. Environ Health Perspect 2008; 116: 1473–9. DOI: 10.1289/ehp.11490
25. Calogero AE, La Vignera S, Condorelli RA et al. Environmental car exhaust pollution damages human sperm chromatin and DNA. J Endocrinol Invest 2011; 34 (6): 139–43. DOI: 10.1007/BF03346722
26. Oldereid NB, Thomassen Y, Purvis K. Seminal plasma lead, cadmium and zinc in relation to tobacco consumption. Int J Androl 1994; 17: 24–8. DOI: 10.1111/j.1365-2605.1994.tb01204.x
27. Lingappa HA, Govindashetty AM, Puttaveerachary AK et al. Evaluation of Effect of Cigarette Smoking on Vital Seminal Parameters which Influence Fertility. J Clin Diagn Res 2015; 9 (7): 13–5. DOI: 10.7860/JCDR/2015/13295.6227
28. Tyuzikov I.A. Metabolic syndrome and male infertility (review) Andrologiya i genital'naya hirurgiya. 2013; 2: 5–10. https://www.elibrary.ru/item.asp?id=21014760 (in Russian).
29. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online 2015; 31 (5): 593–604. DOI: 10.1016/j.rbmo.2015.07.012
30. Trukhan D.I., Viktorova I.A. Nefrologija. Jendokrinologija. Gematologija. Saint Petersburg: SpecLit, 2017. https://fictionbook.ru/author/d_i_truhan/nefrologiya_yendokrinologiya_gematologiya/ (in Russian).
31. Agarwal A, Prabakaran SA, Said TM. Prevention of oxidative stress injury to sperm. J Androl 2005; 26 (6): 654–60. DOI: 10.2164/jandrol.05016
32. Brody S.A. Male factor infertility and oxidative stress: role of diet, lifestyle and nutritional supplements Andrologiya i genital'naya hirurgiya. 2014; 3: 33–41. https://www.elibrary.ru/item.asp?id=22010097 (in Russian).
33. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol 2004; 2: 12. DOI: 10.1186/1477-7827-2-12
34. Cavallini G. Male idiopathic oligoasthenoteratozoospermia. Asian J Androl 2006; 8: 143–57. DOI: 10.1111/j.1745-7262.2006.00123.x
35. Bozhedomov V.A., Gromenko D.S., Ushakova I.V. et al. Oxidative stress of spermatozoa in pathogenesis of male infertility. Urology. 2009; 2: 51–6. https://www.elibrary.ru/item.asp?id=12869861 (in Russian).
36. Aitken RJ, De Iuliis GN, McLachlan RI. Biological and clinical significance of DNA damage in the male germ line. Int J Androl 2009; 32: 46–56. DOI: 10.1111/j.1365-2605.2008.00943.x
37. Bojedomov V.A., Nikolaeva М.А., Ushakova I.V. et. al. Role of free-radical oxidation process in male immune infertility pathogenesis. Rol' processov svobodno-radikal'nogo okisleniya v patogeneze muzhskogo immunnogo besplodiya. Andrologiya i genital'naya hirurgiya. 2010; 4: 62–6. https://www.elibrary.ru/item.asp?id=15488663 (in Russian).
38. Ménézo Y, Entezami F, Lichtblau I et al. Oxidative stress and fertility: false evidence and bad recipes. Gynecol Obstet Fertil 2012; 40 (12): 787–96. DOI: 10.1016/j.gyobfe.2012.09.032
39. Kumar R, Gautam G, Gupta MP. Drug Therapy for Idiopathic Male Infertility: Rationale Versus Evidence. J Urol 2006; 176: 1307–12. DOI: 10.1016/j.juro.2006.06.006
40. Showell MG, Mackenzie-Proctor R, Brown J et al. Antioxidants for male subfertility. Cochrane Database Syst Rev 2014; 12: CD007411. DOI: 10.1002/14651858.CD007411.pub3
41. Eisenberg ML, Lipshultz LI. Varicocele-induced infertility: Newer insights into its pathophysiology. Indian J Urol 2011; 1: 58–64. DOI: 10.4103/0970-1591.78428
42. Sarkar O, Bahrainwala J, Chandrasekaran S et al. Impact of inflammation on male fertility. Front Biosci (Elite ed.) 2011; 3: 89–95. DOI: 10.2741/e223
43. Zhukov O.B., Evdokimov V.V., Zhukov A.A. et al. Professional'noe meditsinskoe soprovozhdenie supruzheskoi pary pri besplodii: sovremennyi podkhod. Consilium Medicum. 2013; 15 (7): 38–43. https://www.elibrary.ru/item.asp?id=20267649 (in Russian).
44. Abad C, Amengual MJ, Gosálvez J et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013; 45 (3): 211–6. DOI: 10.1111/and.12003
45. Efremov E.A., Kasatonova E.V., Mel'nik Ja.I. Male preconception care. Urologiya. 2015; 3: 97–104. https://www.elibrary.ru/item.asp?id=23766606 (in Russian).
46. Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. Clin Invest 2003; 111 (5): 583–93. DOI: 10.1172/JCI18022
47. Trukhan D.I. Puteshestvie v labirinte BAD. Moskovskie apteki. 2006; 9 (153). https://www.mosapteki.ru/modules/articles/article.php?id=447 (in Russian).
48. Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med 1980; 96: 544–50. https://pubmed.ncbi.nlm.nih.gov/6772723/
49. Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl 1981; 7: 69–73. DOI: 10.3109/01485018109009378
50. Kruczynski D, Passia D, Haider SG, Glassmeyer M. Zinc transport through residual bodies in the rat testis; a histochemical study. Andrologia 1985; 17: 98–103. DOI: 10.1111/j.1439-0272.1985.tb00967.x
51. Miura T, Yamauchi K, Takahashi H, Nagahama Y. Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese Eel (Anguilla japonica). Proc Natl Acad Sci USA 1991; 88: 5774–8. DOI: 10.1073/pnas.88.13.5774
52. Favier AE. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res 1992; 32: 363–82. DOI: 10.1007/BF02784623
53. Prasad AS. Zinc: an overview. Nutrition 1995; 11: 93–9. https://pubmed.ncbi.nlm.nih.gov/7749260/
54. Merker HJ, Günther T. Testis damage induced by zinc deficiency in rat. J Trace Element 1997; 11: 19–22. DOI: 10.1016/S0946-672X (97)80004-1
55. Prasad AS. Zinc deficiency. British Med J 2008; 326: 409–10. DOI: 10.1136/bmj.326.7386.409
56. Jalali GR, Roozbeh J et al. Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis. Ren Fail 2010; 32 (4): 417–9. DOI: 10.3109/08860221003706958
57. Sivkov A.V., Oshchepkov V.N., Keshishev N.G. et al. Rol' selena i cinka pri narusheniyah fertil'nosti u muzhchin. Urologiya. 2009; 6: 59–62. https://www.elibrary.ru/item.asp?id=13216440 (in Russian).
58. Neymark A.I., Klepikova I.I. Use of the drug selzinc plus in men with impaired fertility. Andrologiya i genital'naya hirurgiya. 2013; 4: 77–80. https://www.elibrary.ru/item.asp?id=21149905 (in Russian).
59. Sivkov A.V., Oshchepkov V.N., Evdokimov V.V. et al. Effektivnost' i bezopasnost' preparata Seltsink plius u patsientov s khronicheskim neinfektsionnym prostatitom i narusheniiami fertil'nosti. Consilium Medicum. 2011; 13 (7): 5–9. https://www.elibrary.ru/item.asp?id=20226024 (in Russian).
60. Bunk MJ, Dnistrian AM, Schwartz MK, Rivlin RS. Dietary Zn deficiency decreases plasma concentrations of vitamin E. Proc Soc Exp Biol Med 1989; 190: 379–84. DOI: 10.3181/00379727-190-42876
61. Bieri JG. Effect of excessive vitamins C and E on vitamin A status. Am J Clin Nutr 1973; 26 (4): 382–3. DOI: 10.1093/ajcn/26.4.382
62. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
63. Scott R, MacPherson A, Yates RW et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998; 82: 76–80. DOI: 10.1046/j.1464-410x.1998.00683.x
64. Vezina D, Mauffette F, Roberts KD, Bleau G. Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res 1996; 53: 65–83. DOI: 10.1007/BF02784546
65. Keskes-Ammar L, Feki-Chakroun N, Rebai T et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 2003; 49 (2): 83–94. DOI: 10.1080/01485010390129269
66. Eroglu M, Sahin S, Durukan B. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme Q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res 2014; 159 (1–3): 46–51. DOI: 10.1007/s12011-014-9978-7
67. Patrick L. Selenium biochemistry and cancer: review of the literature. Altern Med Rev 2004; 9: 239–58. https://pubmed.ncbi.nlm.nih.gov/15387717/
68. Grinevich V. B., Gubonina I. V., Doshchitsin V. L. et. al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020; 19 (4): 2630. DOI: 10.15829/1728-88002020-2630 (in Russian).
69. Fraga CG, Motchnik PA, Shigenaga MK et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA 1991; 88 (24): 11003–6. DOI: 10.1073/pnas.88.24.11003
70. Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992; 58: 1034–9. https://pubmed.ncbi.nlm.nih.gov/1426355/
71. Harris WA, Harden TE, Dawson EB. Apparent effect of ascorbic acid medication on semen metal levels. Fertil Steril 1979; 32 (4): 455–9. DOI: 10.1016/s0015-0282 (16)44304-9
72. Eskenazi B, Kidd SA, Marks AR et al. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 2005; 20 (4): 1006–12. DOI: 10.1093/humrep/deh725
73. Kessopoulou E, Powers HJ, Sharma KK et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil Steril 1995; 64: 825–31. DOI: 10.1016/s0015-0282 (16)57861-3
74. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
75. Momeni HR, Eskandari N. Effect of vitamin E on sperm parameters and DNA integrity in sodium arsenite-treated rats. Iran J Reprod Med 2012; 10 (3): 249–56. https://pubmed.ncbi.nlm.nih.gov/
25243001/
76. Kliuchnikov S.O. Koenzim Q10. Perspektivy klinicheskogo primeneniia. Pediatrics. Consilium Medicum. 2014; 16 (3): 84–8. https://www.elibrary.ru/item.asp?id=22514383 (in Russian).
77. Wang Y, Hekimi S. The Complexity of Making Ubiquinone. Trends Endocrinol Metab. 2019; 30 (12): 929–43. DOI: 10.1016/j.tem.2019.08.009
78. Beyer RE. The analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Bioche Cell Biol 1998; 70: 390–403. DOI: 10.1139/o92-061
79. Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10 implications in male infertility: biochemical and therapeutic aspects. Biofactors 2005; 25: 165–74. DOI: 10.1002/biof.5520250119
80. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007; 37: 31–7. DOI: 10.1007/s12033-007-0052-y
81. Mancini A, Milardi D, Conte G. Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Horm Metab Res 2005; 37 (7): 428–32. DOI: 10.1055/s-2005-870232
82. Cervellione RM, Cervato G, Zampieri N. Effect of varicocelectomy on the plasma oxidative stress parameters. J Pediatr Surg 2006; 41 (2): 403–6. DOI: 10.1016/j.jpedsurg.2005.11.018
83. Balercia G, Mancini A. Paggi F et al. Coenzyme Q10 and male infertility. J Endocrinol Invest 2009; 32: 626–32. DOI: 10.1007/BF03346521
84. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind., placebo controlled., randomized study. J Urol 2012; 188 (2): 526–31. DOI: 10.1016/j.juro.2012.03.131
85. Galimova E.F. Mechanisms of the protective action of coenzyme q10 in male infertility. Dal'nevostochnyj med. zhurn. 2013; 3: 40–2. https://www.elibrary.ru/item.asp?id=20376359 (in Russian).
86. Banihani SA. A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. Urol J 2017: 1–5. DOI: 10.22037/uj.v0i0.3808
87. Ebisch IM, Thomas CM, Peters WH et al. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007; 13 (2): 163–74. DOI: 10.1093/humupd/dml054
88. Trukhan D.I. Role and location of L-carnitine in cytoprotection and correction of metabolic processes in patients with metabolic syndrome. Meditsinskiy sovet = Medical Council. 2017; (12): 182–7. https://doi.org/10.21518/2079-701X-2017-12-182-187 (in Russian).
89. Pavlov V.N., Galimova E.F., Kataev V.A. et al. The comparative analysis of coenzyme q and l-carnitine antioxidant effects in men with idiopathic pathospermia. Med. vestn. Bashkortostana. 2013; 6: 161–3. https://www.elibrary.ru/item.asp?id=20523092 (in Russian).
90. Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl 1992; 64: 187–96. https://pubmed.ncbi.nlm.nih.gov/1509274/
91. Costa M, Canale D, Filicori M et al. L-carnitine in idiopathic astheno-zoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia 1994; 26: 155–9. https://pubmed.ncbi.nlm.nih.gov/8085668/
92. Lenzi A, Sgro P, Salacone P et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1574–8. DOI: 10.1016/j.fertnstert.2003.10.034
93. Abd-Allah AR, Helal GK, Al-Yahya AA. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. Oxid Med Cell Longev 2009; 2: 73–81. DOI: 10.4161/oxim.2.2.8177
94. Vinogradov I.V., Blokhin A.V., Afanaseva L.M. et al. Usage of L-carnitine in the treatment of the male infertility (a review). Andrologiya i genital'naya hirurgiya. 2009; 2: 19–22. https://www.elibrary.ru/item.asp?id=12838097 (in Russian).
95. Fesenko V.N., Mikhaĭlichenko V.V., Novikov A.I., Fesenko S.V. The influence of L-carnitine tartrate of male reproductive function in fertile age. Problemy reprodukcii. 2011; 6: 63–5. https://www.elibrary.ru/item.asp?id=18948758 (in Russian).
96. Galimov Sh.N., Gromenko D.S., Galimova E.F. et al. Effects of L-carnitine on ejaculate parameters in males from infertile couples. Urologiya. 2012; 1: 47–51. https://www.elibrary.ru/item.asp?id=17706085 (in Russian).
97. Tyuzikov I.A., Kalinchenko S.Yu., Vorslov L.O., Grekov E.A. Optimizaciya klinicheskogo primeneniya kompleksa L-karnitina i acetil-L-karnitina v sovremennoj farmakoterapii idiopaticheskogo muzhskogo besplodiya. Effektivnaya farmakoterapiya. 2013; 1: 44–9. https://www.elibrary.ru/item.asp?id=22267188 (in Russian).
98. Ivanov N.V., Vorohobina N.V. Izuchenie vliyaniya acetil-L-karnitina na osnovnye parametry eyakulyata u muzhchin s idiopaticheskoj astenozoospermiej. Problemy reprodukcii. 2014; 1: 74–6. https://www.elibrary.ru/item.asp?id=21369825 (in Russian).
99. Banihani SA. Vitamin B (12) and Semen Quality. Biomolecules. 2017; 7 (2): 42. DOI: 10.3390/biom7020042
100. Qi YN, Ma J, Han RY et.al. Correlation of the levels of seminal plasma homocysteine, folate and cobalamin with semen parameters in obese men. Zhonghua Nan Ke Xue 2018; 24 (10): 883–6. https://pubmed.ncbi.nlm.nih.gov/32212442/
101. Shvarts G.Ya. Types of Vitamin D Deficiency and Their Pharmacological Correction. Lekarstvennye sredstva. 2011; 2 (3): 33–42. https://www.elibrary.ru/item.asp?id=21104467 (in Russian).
102. Cashman KD, Dowling KG, Škrabáková Z et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103 (4): 1033–44. DOI: 10.3945/ajcn.115.120873
103. Gromova O.A. Vitamin D and its synergists. Lecture. Pediatrics. Consilium Medicum. 2015; 1: 14–9. https://www.elibrary.ru/item.asp?id=23414484 (in Russian).
104. Trukhan D.I. Osteoporosis. Clinical and diagnostic approaches at the outpatient stage. Spravochnik poliklinicheskogo vracha. 2016; 02: 14-7. https://www.elibrary.ru/item.asp?id=26183328 (in Russian).
105. Fu L, Chen YH, Xu S et al. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reprod Toxicol 2017; 73: 241–9. doi: 10.1016/j.reprotox.2017.06.047
106. Jeremy M, Gurusubramanian G, Roy VK. Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. J Steroid Biochem Mol Biol 2019; 190: 64–75. doi: 10.1016/j.jsbmb.2019.03.016
107. Zhu CL, Xu QF, Li SX et al. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia 2016; 48 (10): 1261–6. DOI: 10.1111/and.12570
108. Abbasihormozi S, Kouhkan A, Alizadeh AR et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5 (1): 113–8. DOI: 10.1111/andr.12280
109. Jensen BM, Bjerrum PJ, Jessen TE et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26 (6): 1307–17. DOI: 10.1093/humrep/der059
110. Jensen BM, Lawaetz JG, Petersen JH et al. Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial. J Clin Endocrinol Metab 2018; 103 (3): 870–81. DOI: 10.1210/jc.2017-01656
111. Dabrowski FA, Grzechocinska B, Wielgos M. The role of vitamin D in reproductive health – a Trojan Horse or the Golden Fleece? Nutrients 2015; 7 (6): 4139–53. DOI: 10.3390/nu7064139
112. Scibona M, Meschini P, Capparelli S et al. L-arginine and male infertility. Minerva Urol Nefrol 1994; 46 (4): 251–3. https://pubmed.ncbi.nlm.nih.gov/7701414/
113. Ma P, Zhang Z, Zhou X et al. Characterizing semen abnormality male infertility using non-targeted blood plasma metabolomics. PLoS One 2019; 14 (7): e0219179. DOI: 10.1371
/journal.pone.0219179
114. Kaya OS, Kandemir FM, Gur S et al. Evaluation of the role of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities in rams. Andrologia 2020; 52 (1): e13439. DOI: 10.1111/and.13439
115. Melik Z, Zaletel P, Virtic T, Cankar K. L-arginine as dietary supplement for improving microvascular function. Clin Hemorheol Microcirc 2017; 65 (3): 205–17. DOI: 10.3233/CH-16159
116. El Taieb M, Hegazy E, Ibrahim A. Daily Oral l-Arginine Plus Tadalafil in Diabetic Patients with Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial. J Sex Med 2019; 16 (9): 1390–7. DOI: 10.1016/j.jsxm.2019.06.009
117. Abd-Elrazek AM, Ahmed-Farid OAH. Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. Andrologia 2018; 50 (1). DOI: 10.1111/and.12806
118. Mirhafez SR, Hariri M. L-arginine effect on inflammatory mediators: A systematic review of randomized controlled clinical trials. Int J Vitam Nutr Res 2019. DOI: 10.1024/0300-9831/a000619
119. Smits MR, Mackenzie-Proctor R, Yazdani A et al. Antioxidants for Male Subfertility. Cochrane Database Syst Rev 2019; 3 (3): CD007411. DOI: 10.1002/14651858.CD007411.pub4
120. Garolla A, Petre GC, Francini-Pesenti F et al. Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition. Nutrients 2020; 12 (5): 1472. DOI: 10.3390/nu12051472
121. Filippova O.V. Antioxidants as a way to increase male fertility Effective pharmacotherapy. 2020; 3: 26–32. DOI: 10.33978/2307-3586-2020-16-3-26-32 (in Russian).
2. Examination and processing of human semen. World Health Organization: Geneva, Switzerland, 2010. https://link.springer.com/chapter/10.1007/978-1-4939-2140-9_3
3. Клинические рекомендации. Мужское бесплодие. 2019. Российское общество урологов. https://www.ooorou.ru/ru/page/rcr.html
[Clinical recommendations. Male infertility. 2019. Russian Society of Urology. https://www.ooorou.ru/ru/page/rcr.html (in Russian).]
4. Wong WY, Thomas CMG, Merkus JM et al. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril 2000; 73: 435–42. DOI: 10.1016/s0015-0282 (99)00551-8
5. Jungwirth A, Giwercman A, Tournaye H et al. European Association of Urology Guidelines on Male Infertility: The 2012 Update. Eur Urol 2012; 62 (2): 324–32. DOI: 10.1016/j.eururo.2012.04.048
6. Kopera IA, Bilinska B, Cheng CY, Mruk DD. Sertoli-germ cell junctions in the testis: a review of recent data. Philos Trans R Soc Lond B Biol Sci 2010; 365 (1546): 1593–605. DOI: 10.1098/rstb.2009.0251
7. Lie PP, Mruk DD, Lee WM et al. Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 365: 1581–92. DOI: 10.1098/rstb.2009.0261
8. Mital P, Hinton BT, Dufour JM. The blood-testis and blood-epididymis barriers are more than just their tight junctions. Biol Reprod 2011; 5: 851–8. DOI: 10.1095/biolreprod.110.087452
9. Корнеев И.А. Терапия мужского бесплодия: анализ исследований. Мед. совет. 2019; 13: 99–104. DOI: 10.21518/2079-701X-2019-13-99-104
[Korneev I.A. Male infertility treatments: clinical overview. Meditsinskiy sovet = Medical Council. 2019; 13: 99–104. DOI: 10.21518/2079-701X-2019-13-99-104 (in Russian).]
10. Черных В.Б., Соловова О.А. Мужское бесплодие: взгляд генетика на актуальную проблему. Consilium Medicum. 2019; 21 (7): 19–24. DOI: 10.26442/20751753.2019.7.190517
[Chernykh V.B., Solovova O.A. Male infertility: genetic focus on actual problem. Consilium Medicum. 2019; 21 (7): 19–24. DOI: 10.26442/20751753.2019.7.190517 (in Russian).]
11. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609–13. DOI: 10.1136/bmj.305.6854.609
12. World Health Organization. Laboratory manual for the examination and processing of human semen. 5rd ed. 2010. https://apps.who.int/iris/handle/10665/44261
13. Cooper TG, Noonan E, von Eckardstein S et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16 (3): 231–45. DOI: 10.1093/humupd/dmp048
14. Cao XW, Lin K, Li CY, Yuan CW. A review of WHO Laboratory Manual for the Examination and Processing of Human Semen (5th edition). Zhonghua Nan Ke Xue 2011; 17 (12): 1059–63. https://pubmed.ncbi.nlm.nih.gov/22235670/
15. Трухан Д.И., Макушин Д.Г. Роль и место антиоксидантов в комплексной терапии мужского бесплодия. Consilium Medicum. 2015; 17 (7): 37–43. https://www.elibrary.ru/item.asp?id=24394758
[Trukhan D.I., Makushin D.G. Role and position of antioxidants in complex therapy of male infertility. Consilium Medicum. 2015; 17 (7): 37–43. https://www.elibrary.ru/item.asp?id=24394758 (in Russian).]
16. Male infertility. Available at: https://pubmed.ncbi.nlm.nih.gov/?term=Male+infertility
17. Krausz C, Escamilla AR, Chianese C. Genetics of male infertility: from research to clinic. Reproduction 2015; 150 (5): 159–74. DOI: 10.1530/REP-15-0261
18. Гамидов С., Авакян А. Идиопатическое бесплодие у мужчин: эпидемиология, этиология, патогенез, лечение. Врач. 2013; 7: 2–4. https://www.elibrary.ru/item.asp?id=20205882
[Gamidov S., Avakyan A. Idiopathic male infertility: epidemiolofy, etiology, pathogenesis, treatment. Vrach. 2013; 7: 2–4. https://www.elibrary.ru/item.asp?id=20205882 (in Russian).]
19. Ősapay G, Ősapay K. Stress and Fertility. Orv Hetil 2015; 156 (35): 1430–4. DOI: 10.1556/650.2015.30250
20. De Celis R, Pedron-Nuevo N, Feria-Velasco A. Toxicology of male reproduction in animals and humans. Arch Androl 1996; 37: 201–18. DOI: 10.3109/01485019608988523
21. Hauser R. The environment and male fertility: recent research on emerging chemicals and semen quality. Semin Reprod Med 2006; 24 (3): 156–67. DOI: 10.1055/s-2006-944422
22. Зачепило А.В., Артифексов С.Б. Особенности этиологии и патогенеза нарушений функции мужской репродуктивной системы, обусловленных экологическими факторами. Проблемы репродукции. 2007; 4: 76–80. https://www.elibrary.ru/item.asp?id=13417751
[Zachepilo A.V., Artifeksov S.B. Osobennosti etiologii i patogeneza narushenij funkcii muzhskoj reproduktivnoj sistemy, obuslovlennyh ekologicheskimi faktorami. Problemy reprodukcii. 2007; 4: 76–80. https://www.elibrary.ru/item.asp?id=13417751 (in Russian).]
23. Агаджанян Н.А., Потемина Т.Е., Рыжаков Д.И. Нарушение мужской фертильности в условиях техногенного напряжения. Вестн. восстановительной медицины. 2007; 3: 87–90. https://www.elibrary.ru/item.asp?id=9563649
[Agadzhanyan N.A., Potemina T.E., Ryzhakov D.I. Narushenie muzhskoj fertil'nosti v usloviyah tekhnogennogo napryazheniya. Vestnik vosstanovitel'noj mediciny. 2007; 3: 87–90. https://www.elibrary.ru/item.asp?id=9563649 (in Russian).]
24. Meeker JD, Rossano MG, Protas B et al. Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant. Environ Health Perspect 2008; 116: 1473–9. DOI: 10.1289/ehp.11490
25. Calogero AE, La Vignera S, Condorelli RA et al. Environmental car exhaust pollution damages human sperm chromatin and DNA. J Endocrinol Invest 2011; 34 (6): 139–43. DOI: 10.1007/BF03346722
26. Oldereid NB, Thomassen Y, Purvis K. Seminal plasma lead, cadmium and zinc in relation to tobacco consumption. Int J Androl 1994; 17: 24–8. DOI: 10.1111/j.1365-2605.1994.tb01204.x
27. Lingappa HA, Govindashetty AM, Puttaveerachary AK et al. Evaluation of Effect of Cigarette Smoking on Vital Seminal Parameters which Influence Fertility. J Clin Diagn Res 2015; 9 (7): 13–5. DOI: 10.7860/JCDR/2015/13295.6227
28. Тюзиков И.А. Метаболический синдром и мужское бесплодие (обзор литературы). Андрология и генитальная хирургия. 2013; 2: 5–10. https://www.elibrary.ru/item.asp?id=21014760
[Tyuzikov I.A. Metabolic syndrome and male infertility (review) Andrologiya i genital'naya hirurgiya. 2013; 2: 5–10. https://www.elibrary.ru/item.asp?id=21014760 (in Russian).]
29. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online 2015; 31 (5): 593–604. DOI: 10.1016/j.rbmo.2015.07.012
30. Трухан Д.И., Викторова И.А. Нефрология. Эндокринология. Гематология. СПб.: СпецЛит, 2017. https://fictionbook.ru/author/d_i_truhan/nefrologiya_yendokrinologiya_gematologiya/
[Trukhan D.I., Viktorova I.A. Nefrologija. Jendokrinologija. Gematologija. Saint Petersburg: SpecLit, 2017. https://fictionbook.ru/author/d_i_truhan/nefrologiya_yendokrinologiya_gematologiya/ (in Russian).]
31. Agarwal A, Prabakaran SA, Said TM. Prevention of oxidative stress injury to sperm. J Androl 2005; 26 (6): 654–60. DOI: 10.2164/jandrol.05016
32. Brody S.A. Мужское бесплодие и окислительный стресс: роль диеты, образа жизни и пищевых добавок. Андрология и генитальная хирургия. 2014; 3: 33–41. https://www.elibrary.ru/
item.asp?id=22010097
[Brody S.A. Male factor infertility and oxidative stress: role of diet, lifestyle and nutritional supplements Andrologiya i genital'naya hirurgiya. 2014; 3: 33–41. https://www.elibrary.ru/
item.asp?id=22010097 (in Russian).]
33. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol 2004; 2: 12. DOI: 10.1186/1477-7827-2-12
34. Cavallini G. Male idiopathic oligoasthenoteratozoospermia. Asian J Androl 2006; 8: 143–57. DOI: 10.1111/j.1745-7262.2006.00123.x
35. Божедомов В.А., Громенко Д.С., Ушакова И.В. и др. Оксидативный стресс сперматозоидов в патогенезе мужского бесплодия. Урология. 2009; 2: 51–6. https://www.elibrary.ru/
item.asp?id=12869861
[Bozhedomov V.A., Gromenko D.S., Ushakova I.V. et al. Oxidative stress of spermatozoa in pathogenesis of male infertility. Urology. 2009; 2: 51–6. https://www.elibrary.ru/item.asp?id=12869861 (in Russian).]
36. Aitken RJ, De Iuliis GN, McLachlan RI. Biological and clinical significance of DNA damage in the male germ line. Int J Androl 2009; 32: 46–56. DOI: 10.1111/j.1365-2605.2008.00943.x
37. Божедомов В.А., Николаева М.А., Ушакова И.В. и др. Роль процессов свободно-радикального окисления в патогенезе мужского иммунного бесплодия. Андрология и генитальная хирургия. 2010; 4: 62–6. https://www.elibrary.ru/item.asp?id=15488663
[Bojedomov V.A., Nikolaeva М.А., Ushakova I.V. et. al. Role of free-radical oxidation process in male immune infertility pathogenesis. Rol' processov svobodno-radikal'nogo okisleniya v patogeneze muzhskogo immunnogo besplodiya. Andrologiya i genital'naya hirurgiya. 2010; 4: 62–6. https://www.elibrary.ru/item.asp?id=15488663 (in Russian).]
38. Ménézo Y, Entezami F, Lichtblau I et al. Oxidative stress and fertility: false evidence and bad recipes. Gynecol Obstet Fertil 2012; 40 (12): 787–96. DOI: 10.1016/j.gyobfe.2012.09.032
39. Kumar R, Gautam G, Gupta MP. Drug Therapy for Idiopathic Male Infertility: Rationale Versus Evidence. J Urol 2006; 176: 1307–12. DOI: 10.1016/j.juro.2006.06.006
40. Showell MG, Mackenzie-Proctor R, Brown J et al. Antioxidants for male subfertility. Cochrane Database Syst Rev 2014; 12: CD007411. DOI: 10.1002/14651858.CD007411.pub3
41. Eisenberg ML, Lipshultz LI. Varicocele-induced infertility: Newer insights into its pathophysiology. Indian J Urol 2011; 1: 58–64. DOI: 10.4103/0970-1591.78428
42. Sarkar O, Bahrainwala J, Chandrasekaran S et al. Impact of inflammation on male fertility. Front Biosci (Elite ed.) 2011; 3: 89–95. DOI: 10.2741/e223
43. Жуков О.Б., Евдокимов В.В., Жуков А.А. и др. Профессиональное медицинское сопровождение супружеской пары при бесплодии: современный подход. Consilium Medicum. 2013; 15 (7): 38–43. https://www.elibrary.ru/item.asp?id=20267649
[Zhukov O.B., Evdokimov V.V., Zhukov A.A. et al. Professional'noe meditsinskoe soprovozhdenie supruzheskoi pary pri besplodii: sovremennyi podkhod. Consilium Medicum. 2013; 15 (7): 38–43. https://www.elibrary.ru/item.asp?id=20267649 (in Russian).]
44. Abad C, Amengual MJ, Gosálvez J et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013; 45 (3): 211–6. DOI: 10.1111/and.12003
45. Ефремов Е.А., Касатонова Е.В., Мельник Я.И. Подготовка мужчины к зачатию. Урология. 2015; 3: 97–104. https://www.elibrary.ru/item.asp?id=23766606
[Efremov E.A., Kasatonova E.V., Mel'nik Ja.I. Male preconception care. Urologiya. 2015; 3: 97–104. https://www.elibrary.ru/item.asp?id=23766606 (in Russian).]
46. Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. Clin Invest 2003; 111 (5): 583–93. DOI: 10.1172/JCI18022
47. Трухан Д.И. Путешествие в лабиринте БАД. Московские аптеки. 2006; 9 (153). https://www.mosapteki.ru/modules/articles/article.php?id=447
[Trukhan D.I. Puteshestvie v labirinte BAD. Moskovskie apteki. 2006; 9 (153). https://www.mosapteki.ru/modules/articles/article.php?id=447 (in Russian).]
48. Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med 1980; 96: 544–50. https://pubmed.ncbi.nlm.nih.gov/6772723/
49. Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl 1981; 7: 69–73. DOI: 10.3109/01485018109009378
50. Kruczynski D, Passia D, Haider SG, Glassmeyer M. Zinc transport through residual bodies in the rat testis; a histochemical study. Andrologia 1985; 17: 98–103. DOI: 10.1111/j.1439-0272.1985.tb00967.x
51. Miura T, Yamauchi K, Takahashi H, Nagahama Y. Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese Eel (Anguilla japonica). Proc Natl Acad Sci USA 1991; 88: 5774–8. DOI: 10.1073/pnas.88.13.5774
52. Favier AE. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res 1992; 32: 363–82. DOI: 10.1007/BF02784623
53. Prasad AS. Zinc: an overview. Nutrition 1995; 11: 93–9. https://pubmed.ncbi.nlm.nih.gov/7749260/
54. Merker HJ, Günther T. Testis damage induced by zinc deficiency in rat. J Trace Element 1997; 11: 19–22. DOI: 10.1016/S0946-672X (97)80004-1
55. Prasad AS. Zinc deficiency. British Med J 2008; 326: 409–10. DOI: 10.1136/bmj.326.7386.409
56. Jalali GR, Roozbeh J et al. Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis. Ren Fail 2010; 32 (4): 417–9. DOI: 10.3109/08860221003706958
57. Сивков А.В., Ощепков В.Н., Кешишев Н.Г. и др. Роль селена и цинка при нарушениях фертильности у мужчин. Урология. 2009; 6: 59–62. https://www.elibrary.ru/
item.asp?id=13216440
[Sivkov A.V., Oshchepkov V.N., Keshishev N.G. et al. Rol' selena i cinka pri narusheniyah fertil'nosti u muzhchin. Urologiya. 2009; 6: 59–62. https://www.elibrary.ru/item.asp?id=13216440 (in Russian).]
58. Неймарк А.И., Клепикова И.И. Применение препарата Селцинк плюс у мужчин с нарушением фертильности. Андрология и генитальная хирургия. 2013; 4: 77–80. https://www.elibrary.ru/item.asp?id=21149905
[Neymark A.I., Klepikova I.I. Use of the drug selzinc plus in men with impaired fertility. Andrologiya i genital'naya hirurgiya. 2013; 4: 77–80. https://www.elibrary.ru/item.asp?id=21149905 (in Russian).]
59. Сивков А.В., Ощепков В.Н., Евдокимов В.В. и др. Эффективность и безопасность препарата Селцинк плюс у пациентов с хроническим неинфекционным простатитом и нарушениями фертильности. Consilium Medicum. 2011; 13 (7): 5–9. https://www.elibrary.ru/item.asp?id=20226024
[Sivkov A.V., Oshchepkov V.N., Evdokimov V.V. et al. Effektivnost' i bezopasnost' preparata Seltsink plius u patsientov s khronicheskim neinfektsionnym prostatitom i narusheniiami fertil'nosti. Consilium Medicum. 2011; 13 (7): 5–9. https://www.elibrary.ru/item.asp?id=20226024 (in Russian).]
60. Bunk MJ, Dnistrian AM, Schwartz MK, Rivlin RS. Dietary Zn deficiency decreases plasma concentrations of vitamin E. Proc Soc Exp Biol Med 1989; 190: 379–84. DOI: 10.3181/00379727-190-42876
61. Bieri JG. Effect of excessive vitamins C and E on vitamin A status. Am J Clin Nutr 1973; 26 (4): 382–3. DOI: 10.1093/ajcn/26.4.382
62. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
63. Scott R, MacPherson A, Yates RW et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998; 82: 76–80. DOI: 10.1046/j.1464-410x.1998.00683.x
64. Vezina D, Mauffette F, Roberts KD, Bleau G. Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res 1996; 53: 65–83. DOI: 10.1007/BF02784546
65. Keskes-Ammar L, Feki-Chakroun N, Rebai T et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 2003; 49 (2): 83–94. DOI: 10.1080/01485010390129269
66. Eroglu M, Sahin S, Durukan B. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme Q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res 2014; 159 (1–3): 46–51. DOI: 10.1007/s12011-014-9978-7
67. Patrick L. Selenium biochemistry and cancer: review of the literature. Altern Med Rev 2004; 9: 239–58. https://pubmed.ncbi.nlm.nih.gov/15387717/
68. Гриневич В.Б., Губонина И.В., Дощицин В.Л. и др. Особенности ведения коморбидных пациентов в период пандемии новой коронавирусной инфекции (COVID-19). Национальный Консенсус 2020. Кардиоваскулярная терапия и профилактика. 2020; 19 (4): 2630. doi: 10.15829/1728-8800-2020-2630
[Grinevich V. B., Gubonina I. V., Doshchitsin V. L. et. al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020; 19 (4): 2630. DOI: 10.15829/1728-88002020-2630 (in Russian).]
69. Fraga CG, Motchnik PA, Shigenaga MK et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA 1991; 88 (24): 11003–6. DOI: 10.1073/pnas.88.24.11003
70. Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992; 58: 1034–9. https://pubmed.ncbi.nlm.nih.gov/1426355/
71. Harris WA, Harden TE, Dawson EB. Apparent effect of ascorbic acid medication on semen metal levels. Fertil Steril 1979; 32 (4): 455–9. DOI: 10.1016/s0015-0282 (16)44304-9
72. Eskenazi B, Kidd SA, Marks AR et al. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 2005; 20 (4): 1006–12. DOI: 10.1093/humrep/deh725
73. Kessopoulou E, Powers HJ, Sharma KK et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil Steril 1995; 64: 825–31. DOI: 10.1016/s0015-0282 (16)57861-3
74. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
75. Momeni HR, Eskandari N. Effect of vitamin E on sperm parameters and DNA integrity in sodium arsenite-treated rats. Iran J Reprod Med 2012; 10 (3): 249–56. https://pubmed.ncbi.nlm.nih.gov/
25243001/
76. Ключников С.О. Коэнзим Q10. Перспективы клинического применения. Педиатрия. Приложение к журналу Consilium Medicum. 2014; 16 (3): 84–8. https://www.elibrary.ru/
item.asp?id=22514383
[Kliuchnikov S.O. Koenzim Q10. Perspektivy klinicheskogo primeneniia. Pediatrics. Consilium Medicum. 2014; 16 (3): 84–8. https://www.elibrary.ru/item.asp?id=22514383 (in Russian).]
77. Wang Y, Hekimi S. The Complexity of Making Ubiquinone. Trends Endocrinol Metab. 2019; 30 (12): 929–43. DOI: 10.1016/j.tem.2019.08.009
78. Beyer RE. The analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Bioche Cell Biol 1998; 70: 390–403. DOI: 10.1139/o92-061
79. Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10 implications in male infertility: biochemical and therapeutic aspects. Biofactors 2005; 25: 165–74. DOI: 10.1002/biof.5520250119
80. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007; 37: 31–7. DOI: 10.1007/s12033-007-0052-y
81. Mancini A, Milardi D, Conte G. Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Horm Metab Res 2005; 37 (7): 428–32. DOI: 10.1055/s-2005-870232
82. Cervellione RM, Cervato G, Zampieri N. Effect of varicocelectomy on the plasma oxidative stress parameters. J Pediatr Surg 2006; 41 (2): 403–6. DOI: 10.1016/j.jpedsurg.2005.11.018
83. Balercia G, Mancini A. Paggi F et al. Coenzyme Q10 and male infertility. J Endocrinol Invest 2009; 32: 626–32. DOI: 10.1007/BF03346521
84. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind., placebo controlled., randomized study. J Urol 2012; 188 (2): 526–31. DOI: 10.1016/j.juro.2012.03.131
85. Галимова Э.Ф. Механизмы протективного действия коэнзима Q10 при мужском бесплодии. Дальневосточный мед. журн. 2013; 3: 40–2. https://www.elibrary.ru/item.asp?id=20376359
[Galimova E.F. Mechanisms of the protective action of coenzyme q10 in male infertility. Dal'nevostochnyj med. zhurn. 2013; 3: 40–2. https://www.elibrary.ru/item.asp?id=20376359 (in Russian).]
86. Banihani SA. A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. Urol J 2017: 1–5. DOI: 10.22037/uj.v0i0.3808
87. Ebisch IM, Thomas CM, Peters WH et al. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007; 13 (2): 163–74. DOI: 10.1093/humupd/dml054
88. Трухан Д.И. Роль и место L-карнитина в цитопротекции и коррекции метаболических процессов у пациентов с метаболическим синдромом. Мед. совет. 2017; (12): 182–7. https://doi.org/10.21518/2079-701X-2017-12-182-187
[Trukhan D.I. Role and location of L-carnitine in cytoprotection and correction of metabolic processes in patients with metabolic syndrome. Meditsinskiy sovet = Medical Council. 2017; (12): 182–7. https://doi.org/10.21518/2079-701X-2017-12-182-187 (in Russian).]
89. Павлов В.Н., Галимова Э.Ф., Катаев В.А. и др. Сравнительный анализ антиоксидантных эффектов коэнзима Q и L-карнитина у мужчин с идиопатической патоспермией. Мед. вестн. Башкортостана. 2013; 6: 161–3. https://www.elibrary.ru/item.asp?id=20523092
[Pavlov V.N., Galimova E.F., Kataev V.A. et al. The comparative analysis of coenzyme q and l-carnitine antioxidant effects in men with idiopathic pathospermia. Med. vestn. Bashkortostana. 2013; 6: 161–3. https://www.elibrary.ru/item.asp?id=20523092 (in Russian).]
90. Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl 1992; 64: 187–96. https://pubmed.ncbi.nlm.nih.gov/1509274/
91. Costa M, Canale D, Filicori M et al. L-carnitine in idiopathic astheno-zoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia 1994; 26: 155–9. https://pubmed.ncbi.nlm.nih.gov/8085668/
92. Lenzi A, Sgro P, Salacone P et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1574–8. DOI: 10.1016/j.fertnstert.2003.10.034
93. Abd-Allah AR, Helal GK, Al-Yahya AA. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. Oxid Med Cell Longev 2009; 2: 73–81. DOI: 10.4161/oxim.2.2.8177
94. Виноградов И.В., Блохин А.В., Афанасьева Л.М. Опыт применения L-карнитина в лечении секреторного бесплодия у мужчин (обзор литературы). Андрология и генитальная хирургия. 2009; 2: 19–22. https://www.elibrary.ru/item.asp?id=12838097
[Vinogradov I.V., Blokhin A.V., Afanaseva L.M. et al. Usage of L-carnitine in the treatment of the male infertility (a review). Andrologiya i genital'naya hirurgiya. 2009; 2: 19–22. https://www.elibrary.ru/item.asp?id=12838097 (in Russian).]
95. Фесенко В.Н., Михайличенко В.В., Новиков А.И., Фесенко С.В. Оценка влияния L-карнитина тартрата на репродуктивную мужчин фертильного возраста. Проблемы репродукции. 2011; 6: 63–5. https://www.elibrary.ru/item.asp?id=18948758
[Fesenko V.N., Mikhaĭlichenko V.V., Novikov A.I., Fesenko S.V. The influence of L-carnitine tartrate of male reproductive function in fertile age. Problemy reprodukcii. 2011; 6: 63–5. https://www.elibrary.ru/item.asp?id=18948758 (in Russian).]
96. Галимов Ш.Н., Громенко Д.С., Галимова Э.Ф. и др. Влияние L-карнитина на показатели эякулята у мужчин у бесплодных пар. Урология. 2012; 1: 47–51. https://www.elibrary.ru/
item.asp?id=17706085
[Galimov Sh.N., Gromenko D.S., Galimova E.F. et al. Effects of L-carnitine on ejaculate parameters in males from infertile couples. Urologiya. 2012; 1: 47–51. https://www.elibrary.ru/
item.asp?id=17706085 (in Russian).]
97. Тюзиков И.А., Калинченко С.Ю., Ворслов Л.О., Греков Е.А. Оптимизация клинического применения комплекса L-карнитина и ацетил-L-карнитина в современной фармакотерапии идиопатического мужского бесплодия. Эффективная фармакотерапия. 2013; 1: 44–9. https://www.elibrary.ru/item.asp?id=22267188
[Tyuzikov I.A., Kalinchenko S.Yu., Vorslov L.O., Grekov E.A. Optimizaciya klinicheskogo primeneniya kompleksa L-karnitina i acetil-L-karnitina v sovremennoj farmakoterapii idiopaticheskogo muzhskogo besplodiya. Effektivnaya farmakoterapiya. 2013; 1: 44–9. https://www.elibrary.ru/
item.asp?id=22267188 (in Russian).]
98. Иванов Н.В., Ворохобина Н.В. Изучение влияния ацетил-L-карнитина на основные параметры эякулята у мужчин с идиопатической астенозооспермией. Проблемы репродукции. 2014; 1: 74–6. https://www.elibrary.ru/item.asp?id=21369825
[Ivanov N.V., Vorohobina N.V. Izuchenie vliyaniya acetil-L-karnitina na osnovnye parametry eyakulyata u muzhchin s idiopaticheskoj astenozoospermiej. Problemy reprodukcii. 2014; 1: 74–6. https://www.elibrary.ru/item.asp?id=21369825 (in Russian).]
99. Banihani SA. Vitamin B (12) and Semen Quality. Biomolecules. 2017; 7 (2): 42. DOI: 10.3390/biom7020042
100. Qi YN, Ma J, Han RY et.al. Correlation of the levels of seminal plasma homocysteine, folate and cobalamin with semen parameters in obese men. Zhonghua Nan Ke Xue 2018; 24 (10): 883–6. https://pubmed.ncbi.nlm.nih.gov/32212442/
101. Шварц Г.Я. Типы дефицита витамина D и их фармакологическая коррекция. Лекарственные средства. 2011; 2 (3): 33–42. https://www.elibrary.ru/item.asp?id=21104467
[Shvarts G.Ya. Types of Vitamin D Deficiency and Their Pharmacological Correction. Lekarstvennye sredstva. 2011; 2 (3): 33–42. https://www.elibrary.ru/item.asp?id=21104467 (in Russian).]
102. Cashman KD, Dowling KG, Škrabáková Z et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103 (4): 1033–44. DOI: 10.3945/ajcn.115.120873
103. Громова О.А. Витамин D и его синергисты. Лекция. Consilium Medicum. Педиатрия. 2015; 1: 14–9. https://www.elibrary.ru/item.asp?id=23414484
[Gromova O.A. Vitamin D and its synergists. Lecture. Pediatrics. Consilium Medicum. 2015; 1: 14–9. https://www.elibrary.ru/item.asp?id=23414484 (in Russian).]
104. Трухан Д.И. Остеопороз. Клинико-диагностические подходы на амбулаторно-поликлиническом этапе. Справочник поликлинического врача. 2016; 2: 14–7. https://www.elibrary.ru/
item.asp?id=26183328
[Trukhan D.I. Osteoporosis. Clinical and diagnostic approaches at the outpatient stage. Spravochnik poliklinicheskogo vracha. 2016; 02: 14-7. https://www.elibrary.ru/item.asp?id=26183328 (in Russian).]
105. Fu L, Chen YH, Xu S et al. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reprod Toxicol 2017; 73: 241–9. doi: 10.1016/j.reprotox.2017.06.047
106. Jeremy M, Gurusubramanian G, Roy VK. Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. J Steroid Biochem Mol Biol 2019; 190: 64–75. doi: 10.1016/j.jsbmb.2019.03.016
107. Zhu CL, Xu QF, Li SX et al. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia 2016; 48 (10): 1261–6. DOI: 10.1111/and.12570
108. Abbasihormozi S, Kouhkan A, Alizadeh AR et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5 (1): 113–8. DOI: 10.1111/andr.12280
109. Jensen BM, Bjerrum PJ, Jessen TE et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26 (6): 1307–17. DOI: 10.1093/humrep/der059
110. Jensen BM, Lawaetz JG, Petersen JH et al. Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial. J Clin Endocrinol Metab 2018; 103 (3): 870–81. DOI: 10.1210/jc.2017-01656
111. Dabrowski FA, Grzechocinska B, Wielgos M. The role of vitamin D in reproductive health – a Trojan Horse or the Golden Fleece? Nutrients 2015; 7 (6): 4139–53. DOI: 10.3390/nu7064139
112. Scibona M, Meschini P, Capparelli S et al. L-arginine and male infertility. Minerva Urol Nefrol 1994; 46 (4): 251–3. https://pubmed.ncbi.nlm.nih.gov/7701414/
113. Ma P, Zhang Z, Zhou X et al. Characterizing semen abnormality male infertility using non-targeted blood plasma metabolomics. PLoS One 2019; 14 (7): e0219179. DOI: 10.1371
/journal.pone.0219179
114. Kaya OS, Kandemir FM, Gur S et al. Evaluation of the role of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities in rams. Andrologia 2020; 52 (1): e13439. DOI: 10.1111/and.13439
115. Melik Z, Zaletel P, Virtic T, Cankar K. L-arginine as dietary supplement for improving microvascular function. Clin Hemorheol Microcirc 2017; 65 (3): 205–17. DOI: 10.3233/CH-16159
116. El Taieb M, Hegazy E, Ibrahim A. Daily Oral l-Arginine Plus Tadalafil in Diabetic Patients with Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial. J Sex Med 2019; 16 (9): 1390–7. DOI: 10.1016/j.jsxm.2019.06.009
117. Abd-Elrazek AM, Ahmed-Farid OAH. Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. Andrologia 2018; 50 (1). DOI: 10.1111/and.12806
118. Mirhafez SR, Hariri M. L-arginine effect on inflammatory mediators: A systematic review of randomized controlled clinical trials. Int J Vitam Nutr Res 2019. DOI: 10.1024/0300-9831/a000619
119. Smits MR, Mackenzie-Proctor R, Yazdani A et al. Antioxidants for Male Subfertility. Cochrane Database Syst Rev 2019; 3 (3): CD007411. DOI: 10.1002/14651858.CD007411.pub4
120. Garolla A, Petre GC, Francini-Pesenti F et al. Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition. Nutrients 2020; 12 (5): 1472. DOI: 10.3390/nu12051472
121. Филиппова О.В. Антиоксиданты как способ повышения мужской фертильности. Эффективная фармакотерапия. 2020; 3: 26–32. DOI: 10.33978/2307-3586-2020-16-3-26-32
[Filippova O.V. Antioxidants as a way to increase male fertility Effective pharmacotherapy. 2020; 3: 26–32. DOI: 10.33978/2307-3586-2020-16-3-26-32 (in Russian).]
________________________________________________
0521774748/en/
2. Examination and processing of human semen. World Health Organization: Geneva, Switzerland, 2010. https://link.springer.com/chapter/10.1007/978-1-4939-2140-9_3
3. Clinical recommendations. Male infertility. 2019. Russian Society of Urology. https://www.ooorou.ru/ru/page/rcr.html (in Russian).
4. Wong WY, Thomas CMG, Merkus JM et al. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril 2000; 73: 435–42. DOI: 10.1016/s0015-0282 (99)00551-8
5. Jungwirth A, Giwercman A, Tournaye H et al. European Association of Urology Guidelines on Male Infertility: The 2012 Update. Eur Urol 2012; 62 (2): 324–32. DOI: 10.1016/j.eururo.2012.04.048
6. Kopera IA, Bilinska B, Cheng CY, Mruk DD. Sertoli-germ cell junctions in the testis: a review of recent data. Philos Trans R Soc Lond B Biol Sci 2010; 365 (1546): 1593–605. DOI: 10.1098/rstb.2009.0251
7. Lie PP, Mruk DD, Lee WM et al. Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 365: 1581–92. DOI: 10.1098/rstb.2009.0261
8. Mital P, Hinton BT, Dufour JM. The blood-testis and blood-epididymis barriers are more than just their tight junctions. Biol Reprod 2011; 5: 851–8. DOI: 10.1095/biolreprod.110.087452
9. Korneev I.A. Male infertility treatments: clinical overview. Meditsinskiy sovet = Medical Council. 2019; 13: 99–104. DOI: 10.21518/2079-701X-2019-13-99-104 (in Russian).
10. Chernykh V.B., Solovova O.A. Male infertility: genetic focus on actual problem. Consilium Medicum. 2019; 21 (7): 19–24. DOI: 10.26442/20751753.2019.7.190517 (in Russian).
11. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609–13. DOI: 10.1136/bmj.305.6854.609
12. World Health Organization. Laboratory manual for the examination and processing of human semen. 5rd ed. 2010. https://apps.who.int/iris/handle/10665/44261
13. Cooper TG, Noonan E, von Eckardstein S et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16 (3): 231–45. DOI: 10.1093/humupd/dmp048
14. Cao XW, Lin K, Li CY, Yuan CW. A review of WHO Laboratory Manual for the Examination and Processing of Human Semen (5th edition). Zhonghua Nan Ke Xue 2011; 17 (12): 1059–63. https://pubmed.ncbi.nlm.nih.gov/22235670/
15. Trukhan D.I., Makushin D.G. Role and position of antioxidants in complex therapy of male infertility. Consilium Medicum. 2015; 17 (7): 37–43. https://www.elibrary.ru/item.asp?id=24394758 (in Russian).
16. Male infertility. Available at: https://pubmed.ncbi.nlm.nih.gov/?term=Male+infertility
17. Krausz C, Escamilla AR, Chianese C. Genetics of male infertility: from research to clinic. Reproduction 2015; 150 (5): 159–74. DOI: 10.1530/REP-15-0261
18. Gamidov S., Avakyan A. Idiopathic male infertility: epidemiolofy, etiology, pathogenesis, treatment. Vrach. 2013; 7: 2–4. https://www.elibrary.ru/item.asp?id=20205882 (in Russian).
19. Ősapay G, Ősapay K. Stress and Fertility. Orv Hetil 2015; 156 (35): 1430–4. DOI: 10.1556/650.2015.30250
20. De Celis R, Pedron-Nuevo N, Feria-Velasco A. Toxicology of male reproduction in animals and humans. Arch Androl 1996; 37: 201–18. DOI: 10.3109/01485019608988523
21. Hauser R. The environment and male fertility: recent research on emerging chemicals and semen quality. Semin Reprod Med 2006; 24 (3): 156–67. DOI: 10.1055/s-2006-944422
22. Zachepilo A.V., Artifeksov S.B. Osobennosti etiologii i patogeneza narushenij funkcii muzhskoj reproduktivnoj sistemy, obuslovlennyh ekologicheskimi faktorami. Problemy reprodukcii. 2007; 4: 76–80. https://www.elibrary.ru/item.asp?id=13417751 (in Russian).
23. Agadzhanyan N.A., Potemina T.E., Ryzhakov D.I. Narushenie muzhskoj fertil'nosti v usloviyah tekhnogennogo napryazheniya. Vestnik vosstanovitel'noj mediciny. 2007; 3: 87–90. https://www.elibrary.ru/item.asp?id=9563649 (in Russian).
24. Meeker JD, Rossano MG, Protas B et al. Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant. Environ Health Perspect 2008; 116: 1473–9. DOI: 10.1289/ehp.11490
25. Calogero AE, La Vignera S, Condorelli RA et al. Environmental car exhaust pollution damages human sperm chromatin and DNA. J Endocrinol Invest 2011; 34 (6): 139–43. DOI: 10.1007/BF03346722
26. Oldereid NB, Thomassen Y, Purvis K. Seminal plasma lead, cadmium and zinc in relation to tobacco consumption. Int J Androl 1994; 17: 24–8. DOI: 10.1111/j.1365-2605.1994.tb01204.x
27. Lingappa HA, Govindashetty AM, Puttaveerachary AK et al. Evaluation of Effect of Cigarette Smoking on Vital Seminal Parameters which Influence Fertility. J Clin Diagn Res 2015; 9 (7): 13–5. DOI: 10.7860/JCDR/2015/13295.6227
28. Tyuzikov I.A. Metabolic syndrome and male infertility (review) Andrologiya i genital'naya hirurgiya. 2013; 2: 5–10. https://www.elibrary.ru/item.asp?id=21014760 (in Russian).
29. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online 2015; 31 (5): 593–604. DOI: 10.1016/j.rbmo.2015.07.012
30. Trukhan D.I., Viktorova I.A. Nefrologija. Jendokrinologija. Gematologija. Saint Petersburg: SpecLit, 2017. https://fictionbook.ru/author/d_i_truhan/nefrologiya_yendokrinologiya_gematologiya/ (in Russian).
31. Agarwal A, Prabakaran SA, Said TM. Prevention of oxidative stress injury to sperm. J Androl 2005; 26 (6): 654–60. DOI: 10.2164/jandrol.05016
32. Brody S.A. Male factor infertility and oxidative stress: role of diet, lifestyle and nutritional supplements Andrologiya i genital'naya hirurgiya. 2014; 3: 33–41. https://www.elibrary.ru/item.asp?id=22010097 (in Russian).
33. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol 2004; 2: 12. DOI: 10.1186/1477-7827-2-12
34. Cavallini G. Male idiopathic oligoasthenoteratozoospermia. Asian J Androl 2006; 8: 143–57. DOI: 10.1111/j.1745-7262.2006.00123.x
35. Bozhedomov V.A., Gromenko D.S., Ushakova I.V. et al. Oxidative stress of spermatozoa in pathogenesis of male infertility. Urology. 2009; 2: 51–6. https://www.elibrary.ru/item.asp?id=12869861 (in Russian).
36. Aitken RJ, De Iuliis GN, McLachlan RI. Biological and clinical significance of DNA damage in the male germ line. Int J Androl 2009; 32: 46–56. DOI: 10.1111/j.1365-2605.2008.00943.x
37. Bojedomov V.A., Nikolaeva М.А., Ushakova I.V. et. al. Role of free-radical oxidation process in male immune infertility pathogenesis. Rol' processov svobodno-radikal'nogo okisleniya v patogeneze muzhskogo immunnogo besplodiya. Andrologiya i genital'naya hirurgiya. 2010; 4: 62–6. https://www.elibrary.ru/item.asp?id=15488663 (in Russian).
38. Ménézo Y, Entezami F, Lichtblau I et al. Oxidative stress and fertility: false evidence and bad recipes. Gynecol Obstet Fertil 2012; 40 (12): 787–96. DOI: 10.1016/j.gyobfe.2012.09.032
39. Kumar R, Gautam G, Gupta MP. Drug Therapy for Idiopathic Male Infertility: Rationale Versus Evidence. J Urol 2006; 176: 1307–12. DOI: 10.1016/j.juro.2006.06.006
40. Showell MG, Mackenzie-Proctor R, Brown J et al. Antioxidants for male subfertility. Cochrane Database Syst Rev 2014; 12: CD007411. DOI: 10.1002/14651858.CD007411.pub3
41. Eisenberg ML, Lipshultz LI. Varicocele-induced infertility: Newer insights into its pathophysiology. Indian J Urol 2011; 1: 58–64. DOI: 10.4103/0970-1591.78428
42. Sarkar O, Bahrainwala J, Chandrasekaran S et al. Impact of inflammation on male fertility. Front Biosci (Elite ed.) 2011; 3: 89–95. DOI: 10.2741/e223
43. Zhukov O.B., Evdokimov V.V., Zhukov A.A. et al. Professional'noe meditsinskoe soprovozhdenie supruzheskoi pary pri besplodii: sovremennyi podkhod. Consilium Medicum. 2013; 15 (7): 38–43. https://www.elibrary.ru/item.asp?id=20267649 (in Russian).
44. Abad C, Amengual MJ, Gosálvez J et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013; 45 (3): 211–6. DOI: 10.1111/and.12003
45. Efremov E.A., Kasatonova E.V., Mel'nik Ja.I. Male preconception care. Urologiya. 2015; 3: 97–104. https://www.elibrary.ru/item.asp?id=23766606 (in Russian).
46. Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. Clin Invest 2003; 111 (5): 583–93. DOI: 10.1172/JCI18022
47. Trukhan D.I. Puteshestvie v labirinte BAD. Moskovskie apteki. 2006; 9 (153). https://www.mosapteki.ru/modules/articles/article.php?id=447 (in Russian).
48. Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med 1980; 96: 544–50. https://pubmed.ncbi.nlm.nih.gov/6772723/
49. Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl 1981; 7: 69–73. DOI: 10.3109/01485018109009378
50. Kruczynski D, Passia D, Haider SG, Glassmeyer M. Zinc transport through residual bodies in the rat testis; a histochemical study. Andrologia 1985; 17: 98–103. DOI: 10.1111/j.1439-0272.1985.tb00967.x
51. Miura T, Yamauchi K, Takahashi H, Nagahama Y. Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese Eel (Anguilla japonica). Proc Natl Acad Sci USA 1991; 88: 5774–8. DOI: 10.1073/pnas.88.13.5774
52. Favier AE. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res 1992; 32: 363–82. DOI: 10.1007/BF02784623
53. Prasad AS. Zinc: an overview. Nutrition 1995; 11: 93–9. https://pubmed.ncbi.nlm.nih.gov/7749260/
54. Merker HJ, Günther T. Testis damage induced by zinc deficiency in rat. J Trace Element 1997; 11: 19–22. DOI: 10.1016/S0946-672X (97)80004-1
55. Prasad AS. Zinc deficiency. British Med J 2008; 326: 409–10. DOI: 10.1136/bmj.326.7386.409
56. Jalali GR, Roozbeh J et al. Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis. Ren Fail 2010; 32 (4): 417–9. DOI: 10.3109/08860221003706958
57. Sivkov A.V., Oshchepkov V.N., Keshishev N.G. et al. Rol' selena i cinka pri narusheniyah fertil'nosti u muzhchin. Urologiya. 2009; 6: 59–62. https://www.elibrary.ru/item.asp?id=13216440 (in Russian).
58. Neymark A.I., Klepikova I.I. Use of the drug selzinc plus in men with impaired fertility. Andrologiya i genital'naya hirurgiya. 2013; 4: 77–80. https://www.elibrary.ru/item.asp?id=21149905 (in Russian).
59. Sivkov A.V., Oshchepkov V.N., Evdokimov V.V. et al. Effektivnost' i bezopasnost' preparata Seltsink plius u patsientov s khronicheskim neinfektsionnym prostatitom i narusheniiami fertil'nosti. Consilium Medicum. 2011; 13 (7): 5–9. https://www.elibrary.ru/item.asp?id=20226024 (in Russian).
60. Bunk MJ, Dnistrian AM, Schwartz MK, Rivlin RS. Dietary Zn deficiency decreases plasma concentrations of vitamin E. Proc Soc Exp Biol Med 1989; 190: 379–84. DOI: 10.3181/00379727-190-42876
61. Bieri JG. Effect of excessive vitamins C and E on vitamin A status. Am J Clin Nutr 1973; 26 (4): 382–3. DOI: 10.1093/ajcn/26.4.382
62. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
63. Scott R, MacPherson A, Yates RW et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998; 82: 76–80. DOI: 10.1046/j.1464-410x.1998.00683.x
64. Vezina D, Mauffette F, Roberts KD, Bleau G. Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res 1996; 53: 65–83. DOI: 10.1007/BF02784546
65. Keskes-Ammar L, Feki-Chakroun N, Rebai T et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 2003; 49 (2): 83–94. DOI: 10.1080/01485010390129269
66. Eroglu M, Sahin S, Durukan B. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme Q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res 2014; 159 (1–3): 46–51. DOI: 10.1007/s12011-014-9978-7
67. Patrick L. Selenium biochemistry and cancer: review of the literature. Altern Med Rev 2004; 9: 239–58. https://pubmed.ncbi.nlm.nih.gov/15387717/
68. Grinevich V. B., Gubonina I. V., Doshchitsin V. L. et. al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020; 19 (4): 2630. DOI: 10.15829/1728-88002020-2630 (in Russian).
69. Fraga CG, Motchnik PA, Shigenaga MK et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA 1991; 88 (24): 11003–6. DOI: 10.1073/pnas.88.24.11003
70. Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992; 58: 1034–9. https://pubmed.ncbi.nlm.nih.gov/1426355/
71. Harris WA, Harden TE, Dawson EB. Apparent effect of ascorbic acid medication on semen metal levels. Fertil Steril 1979; 32 (4): 455–9. DOI: 10.1016/s0015-0282 (16)44304-9
72. Eskenazi B, Kidd SA, Marks AR et al. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 2005; 20 (4): 1006–12. DOI: 10.1093/humrep/deh725
73. Kessopoulou E, Powers HJ, Sharma KK et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil Steril 1995; 64: 825–31. DOI: 10.1016/s0015-0282 (16)57861-3
74. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003; 63 (20): 6988–95. https://pubmed.ncbi.nlm.nih.gov/14583501/
75. Momeni HR, Eskandari N. Effect of vitamin E on sperm parameters and DNA integrity in sodium arsenite-treated rats. Iran J Reprod Med 2012; 10 (3): 249–56. https://pubmed.ncbi.nlm.nih.gov/
25243001/
76. Kliuchnikov S.O. Koenzim Q10. Perspektivy klinicheskogo primeneniia. Pediatrics. Consilium Medicum. 2014; 16 (3): 84–8. https://www.elibrary.ru/item.asp?id=22514383 (in Russian).
77. Wang Y, Hekimi S. The Complexity of Making Ubiquinone. Trends Endocrinol Metab. 2019; 30 (12): 929–43. DOI: 10.1016/j.tem.2019.08.009
78. Beyer RE. The analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Bioche Cell Biol 1998; 70: 390–403. DOI: 10.1139/o92-061
79. Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10 implications in male infertility: biochemical and therapeutic aspects. Biofactors 2005; 25: 165–74. DOI: 10.1002/biof.5520250119
80. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007; 37: 31–7. DOI: 10.1007/s12033-007-0052-y
81. Mancini A, Milardi D, Conte G. Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Horm Metab Res 2005; 37 (7): 428–32. DOI: 10.1055/s-2005-870232
82. Cervellione RM, Cervato G, Zampieri N. Effect of varicocelectomy on the plasma oxidative stress parameters. J Pediatr Surg 2006; 41 (2): 403–6. DOI: 10.1016/j.jpedsurg.2005.11.018
83. Balercia G, Mancini A. Paggi F et al. Coenzyme Q10 and male infertility. J Endocrinol Invest 2009; 32: 626–32. DOI: 10.1007/BF03346521
84. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind., placebo controlled., randomized study. J Urol 2012; 188 (2): 526–31. DOI: 10.1016/j.juro.2012.03.131
85. Galimova E.F. Mechanisms of the protective action of coenzyme q10 in male infertility. Dal'nevostochnyj med. zhurn. 2013; 3: 40–2. https://www.elibrary.ru/item.asp?id=20376359 (in Russian).
86. Banihani SA. A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. Urol J 2017: 1–5. DOI: 10.22037/uj.v0i0.3808
87. Ebisch IM, Thomas CM, Peters WH et al. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007; 13 (2): 163–74. DOI: 10.1093/humupd/dml054
88. Trukhan D.I. Role and location of L-carnitine in cytoprotection and correction of metabolic processes in patients with metabolic syndrome. Meditsinskiy sovet = Medical Council. 2017; (12): 182–7. https://doi.org/10.21518/2079-701X-2017-12-182-187 (in Russian).
89. Pavlov V.N., Galimova E.F., Kataev V.A. et al. The comparative analysis of coenzyme q and l-carnitine antioxidant effects in men with idiopathic pathospermia. Med. vestn. Bashkortostana. 2013; 6: 161–3. https://www.elibrary.ru/item.asp?id=20523092 (in Russian).
90. Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl 1992; 64: 187–96. https://pubmed.ncbi.nlm.nih.gov/1509274/
91. Costa M, Canale D, Filicori M et al. L-carnitine in idiopathic astheno-zoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia 1994; 26: 155–9. https://pubmed.ncbi.nlm.nih.gov/8085668/
92. Lenzi A, Sgro P, Salacone P et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1574–8. DOI: 10.1016/j.fertnstert.2003.10.034
93. Abd-Allah AR, Helal GK, Al-Yahya AA. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. Oxid Med Cell Longev 2009; 2: 73–81. DOI: 10.4161/oxim.2.2.8177
94. Vinogradov I.V., Blokhin A.V., Afanaseva L.M. et al. Usage of L-carnitine in the treatment of the male infertility (a review). Andrologiya i genital'naya hirurgiya. 2009; 2: 19–22. https://www.elibrary.ru/item.asp?id=12838097 (in Russian).
95. Fesenko V.N., Mikhaĭlichenko V.V., Novikov A.I., Fesenko S.V. The influence of L-carnitine tartrate of male reproductive function in fertile age. Problemy reprodukcii. 2011; 6: 63–5. https://www.elibrary.ru/item.asp?id=18948758 (in Russian).
96. Galimov Sh.N., Gromenko D.S., Galimova E.F. et al. Effects of L-carnitine on ejaculate parameters in males from infertile couples. Urologiya. 2012; 1: 47–51. https://www.elibrary.ru/item.asp?id=17706085 (in Russian).
97. Tyuzikov I.A., Kalinchenko S.Yu., Vorslov L.O., Grekov E.A. Optimizaciya klinicheskogo primeneniya kompleksa L-karnitina i acetil-L-karnitina v sovremennoj farmakoterapii idiopaticheskogo muzhskogo besplodiya. Effektivnaya farmakoterapiya. 2013; 1: 44–9. https://www.elibrary.ru/item.asp?id=22267188 (in Russian).
98. Ivanov N.V., Vorohobina N.V. Izuchenie vliyaniya acetil-L-karnitina na osnovnye parametry eyakulyata u muzhchin s idiopaticheskoj astenozoospermiej. Problemy reprodukcii. 2014; 1: 74–6. https://www.elibrary.ru/item.asp?id=21369825 (in Russian).
99. Banihani SA. Vitamin B (12) and Semen Quality. Biomolecules. 2017; 7 (2): 42. DOI: 10.3390/biom7020042
100. Qi YN, Ma J, Han RY et.al. Correlation of the levels of seminal plasma homocysteine, folate and cobalamin with semen parameters in obese men. Zhonghua Nan Ke Xue 2018; 24 (10): 883–6. https://pubmed.ncbi.nlm.nih.gov/32212442/
101. Shvarts G.Ya. Types of Vitamin D Deficiency and Their Pharmacological Correction. Lekarstvennye sredstva. 2011; 2 (3): 33–42. https://www.elibrary.ru/item.asp?id=21104467 (in Russian).
102. Cashman KD, Dowling KG, Škrabáková Z et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103 (4): 1033–44. DOI: 10.3945/ajcn.115.120873
103. Gromova O.A. Vitamin D and its synergists. Lecture. Pediatrics. Consilium Medicum. 2015; 1: 14–9. https://www.elibrary.ru/item.asp?id=23414484 (in Russian).
104. Trukhan D.I. Osteoporosis. Clinical and diagnostic approaches at the outpatient stage. Spravochnik poliklinicheskogo vracha. 2016; 02: 14-7. https://www.elibrary.ru/item.asp?id=26183328 (in Russian).
105. Fu L, Chen YH, Xu S et al. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reprod Toxicol 2017; 73: 241–9. doi: 10.1016/j.reprotox.2017.06.047
106. Jeremy M, Gurusubramanian G, Roy VK. Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. J Steroid Biochem Mol Biol 2019; 190: 64–75. doi: 10.1016/j.jsbmb.2019.03.016
107. Zhu CL, Xu QF, Li SX et al. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia 2016; 48 (10): 1261–6. DOI: 10.1111/and.12570
108. Abbasihormozi S, Kouhkan A, Alizadeh AR et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5 (1): 113–8. DOI: 10.1111/andr.12280
109. Jensen BM, Bjerrum PJ, Jessen TE et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26 (6): 1307–17. DOI: 10.1093/humrep/der059
110. Jensen BM, Lawaetz JG, Petersen JH et al. Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial. J Clin Endocrinol Metab 2018; 103 (3): 870–81. DOI: 10.1210/jc.2017-01656
111. Dabrowski FA, Grzechocinska B, Wielgos M. The role of vitamin D in reproductive health – a Trojan Horse or the Golden Fleece? Nutrients 2015; 7 (6): 4139–53. DOI: 10.3390/nu7064139
112. Scibona M, Meschini P, Capparelli S et al. L-arginine and male infertility. Minerva Urol Nefrol 1994; 46 (4): 251–3. https://pubmed.ncbi.nlm.nih.gov/7701414/
113. Ma P, Zhang Z, Zhou X et al. Characterizing semen abnormality male infertility using non-targeted blood plasma metabolomics. PLoS One 2019; 14 (7): e0219179. DOI: 10.1371
/journal.pone.0219179
114. Kaya OS, Kandemir FM, Gur S et al. Evaluation of the role of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities in rams. Andrologia 2020; 52 (1): e13439. DOI: 10.1111/and.13439
115. Melik Z, Zaletel P, Virtic T, Cankar K. L-arginine as dietary supplement for improving microvascular function. Clin Hemorheol Microcirc 2017; 65 (3): 205–17. DOI: 10.3233/CH-16159
116. El Taieb M, Hegazy E, Ibrahim A. Daily Oral l-Arginine Plus Tadalafil in Diabetic Patients with Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial. J Sex Med 2019; 16 (9): 1390–7. DOI: 10.1016/j.jsxm.2019.06.009
117. Abd-Elrazek AM, Ahmed-Farid OAH. Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. Andrologia 2018; 50 (1). DOI: 10.1111/and.12806
118. Mirhafez SR, Hariri M. L-arginine effect on inflammatory mediators: A systematic review of randomized controlled clinical trials. Int J Vitam Nutr Res 2019. DOI: 10.1024/0300-9831/a000619
119. Smits MR, Mackenzie-Proctor R, Yazdani A et al. Antioxidants for Male Subfertility. Cochrane Database Syst Rev 2019; 3 (3): CD007411. DOI: 10.1002/14651858.CD007411.pub4
120. Garolla A, Petre GC, Francini-Pesenti F et al. Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition. Nutrients 2020; 12 (5): 1472. DOI: 10.3390/nu12051472
121. Filippova O.V. Antioxidants as a way to increase male fertility Effective pharmacotherapy. 2020; 3: 26–32. DOI: 10.33978/2307-3586-2020-16-3-26-32 (in Russian).
Авторы
Д.Г. Макушин1,2, Л.В. Белкина3, Д.И. Трухан*2
1 ФГБУЗ «Западно-Сибирский медицинский центр» ФГБУЗ ФМБА России, Омск, Россия;
2 ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия;
3 БУ ДПО ОО «Омский областной центр повышения квалификации работников здравоохранения», Омск, Россия
*dmitry_trukhan@mail.ru
1 West Siberian Medical Center, Omsk, Russia;
2 Omsk State Medical University, Omsk, Russia;
3 Omsk Regional Center for the Advanced Training of Health Care Workers, Omsk, Russia
*dmitry_trukhan@mail.ru
1 ФГБУЗ «Западно-Сибирский медицинский центр» ФГБУЗ ФМБА России, Омск, Россия;
2 ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия;
3 БУ ДПО ОО «Омский областной центр повышения квалификации работников здравоохранения», Омск, Россия
*dmitry_trukhan@mail.ru
________________________________________________
1 West Siberian Medical Center, Omsk, Russia;
2 Omsk State Medical University, Omsk, Russia;
3 Omsk Regional Center for the Advanced Training of Health Care Workers, Omsk, Russia
*dmitry_trukhan@mail.ru
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