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Постинсультная апатия
Постинсультная апатия
Петрова Е.А., Поневежская Е.В., Савина М.А., Кольцова Е.А. Постинсультная апатия. Consilium Medicum. 2020; 22 (9): 33–37. DOI: 10.26442/20751753.2020.9.200274
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Аннотация
Статья посвящена проблеме постинсультной апатии, которая признается важным нейропсихиатрическим синдромом, что связано с ее воздействием на эффективность реабилитации, социальную адаптацию больного, возвращение к трудовой активности. В работе представлены литературные данные по распространенности, клиническим проявлениям, диагностическим критериям постинсультной апатии, ассоциация ее с возрастом, полом, депрессией, когнитивной дисфункцией. Рассмотрены вопросы патогенеза постинсультной апатии, взаимосвязи с локализацией очага поражения мозга, тяжестью инсульта, представлены направления лечения и прогноз.
Ключевые слова: инсульт, постинсультная апатия.
Key words: stroke, post-stroke apathy.
Ключевые слова: инсульт, постинсультная апатия.
________________________________________________
Key words: stroke, post-stroke apathy.
Полный текст
Список литературы
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25. Starkstein SE, Petracca G, Chemerinski E et al. Syndromic validity of apathy in Alzheimer’s disease. Am J Psychiatry 2001; 158: 872–7.
26. Strauss ME, Sperry SD. An informant-based assessment of apathy in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol 2002; 15 (3): 176–83.
27. Robert PH, Clairet S, Benoit M et al. The apathy inventory: assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. Int J Geriatr Psychiatry 2002; 17 (12): 1099–105.
28. Robert P, Onyike CU, Leentjens AF et al. Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. Eur Psychiatry 2009; 24: 98–104.
29. Mayo NE, Fellows LK, Scott SC et al. A longitudinal view of apathy and its impact after stroke. Stroke 2009; 40: 3299–307.
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31. Cameron JI, Cheung AM, Streiner DL et al. Stroke survivors' behavioral and psychologic symptoms are associated with informal caregivers' experiences of depression. Arch Physical Med Rehabil 2006; 87: 177–83.
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[Nodel' M.R., Iakhno N.N. Apatiia pri bolezni Parkinsona. Nevrolog. zhurn. 2014; 1: 9–15 (in Russian).]
34. Den Brok MG, van Dalen JW, van Gool WA et al. Apathy in Parkinson's disease: a systematic review and meta-analysis. Mov Dis 2015; 30 (6): 759–69.
35. Clarke DE, van Reekum R, Simard M et al. Apathy in dementia: clinical and sociodemographic correlates. J Neuropsychiatry Clin Neurosci 2008; 20 (3): 337–47.
36. Вознесенская Т.Г. Депрессия в пожилом возрасте. Consilium Medical. 2000; 11: 74–9.
[Voznesenskaia T.G. Depression in old age. Consilium Medical. 2000; 11: 74–9 (in Russian).]
37. Goldfine АМ, Dehbandi В, Briana S et al. Quantifying post-stroke apathy with actimeters. J Neuropsychiatry Clin Neurosci 2016; 28 (3): 199–204.
38. Петрова Е.А., Поневежская Е.В., Савина М.А., Скворцова В.И. Клинические особенности постинсультной апатии. Журн. неврологии и психиатрии им. С.С. Корсакова. 2012; 12: 15–9.
[Petrova E.A., Ponevezhskaia E.V., Savina M.A., Skvortsova V.I. Klinicheskie osobennosti postinsul'tnoi apatii. Zhurn. nevrologii i psikhiatrii im. S.S. Korsakova. 2012; 12: 15–9 (in Russian).]
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41. Harvey PO, Fossati P, Pochon JB et al. Cognitive control and brain resources in major depression. Neuroimage 2005; 26: 860–69.
42. Andersson S, Krogstad JM, Finset A. Apathy and depressed mood in acquired brain damage: relationship to lesion localization and psychophysiological reactivity. Psychol Med 1999; 29: 447–56.
43. Starkstein SE, Fedoroff JP, Price TR et al. Apathy following cerebrovascular lesions. Stroke 1993; 24: 1625–30.
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[Bogolepova A.N. Depressive disorders in patients with cerebrovascular pathology. Handbook for Practitioners Doctors. 2006; 8 (in Russian).]
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47. McGilchrist I, Goldstein LH, Jadresic D et al. Thalamo-frontal psychosis. Br J Psychiatry 1993; 163: 113–5.
48. Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994; 117: 859–76.
49. Okada K, Kobayashi S, Yamagata S et al. Poststroke apathy and regional cerebral blood flow. Stroke 1997; 28: 2437–41.
50. Parks RW, Crockett DJ, Manji HK et al. Assessment of bromocriptine intervention for the treatment of frontal lobe syndrome: a case study. J Neuropsychiatry Clin Neurosci 1992; 4: 109–11.
51. Watanabe MD, Martin EM, DeLeon OA et al. Successful methylphenidate treatment of apathy after subcortical infarcts. J Neuropsychiatry Clin Neurosci 1995; 7: 502–4.
52. Doody RS, Massman P, Mahurin R et al. Positive and negative neuropsychiatric features in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 1995; 7: 54–60.
53. Galynker I, Ieronimo C, Miner C et al. Methylphenidate treatment of negative symptoms in patients with dementia. J Neuropsychiatry Clin Neurosci 1997; 9: 231–39.
54. Reichman WE, Coyne AC, Amirneni S et al. Negative symptoms in Alzheimer’s disease. Am J Psychiatry 1996; 153: 424–6.
55. Aarsland DА, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson’s disease with dementia and Alzheimer’s disease. Int J Geriatr Psychiatry 2001; 16: 184–91.
56. Paulsen JS, Ready RE, Hamilton JM et al. Neuropsychiatric aspects of Huntington’s disease. J Neuro Neurosurg Psychiatry 2001; 71: 310–4.
57. Narushima K, Robinson RG. The effect of early versus late antidepressant treatment on physical impairment associated with poststroke depression: is there a time-related therapeutic window? J Nerv Ment Dis 2003; 191 (10): 645–52.
58. Rasmussen A, Lunde M, Poulsen DL et al. A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 2003; 44 (3): 216–21.
59. Zhang LS, Hu XY, Yao LY et al. Prophylactic effects of duloxetine on post-stroke depression symptoms: an open single-blind trial. Eur Neurol 2013; 69 (6): 336–43.
60. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
61. Flaster M, Sharma A, Rao M. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery. Top Stroke Rehabil 2013; 20 (2): 139–50.
62. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
63. Hama S, Yamashita H, Shigenobu M et al. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia. Eur Arch Psychiatry Clin Neurosci 2011; 257 (3): 149–52.
64. Santa N, Sugimori H, Kusuda K et al. Apathy and functional recovery following first-ever stroke. Int J Rehabil Res 2008; 31 (4): 321–6.
2. Kim JS Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms. J Stroke 2016; 18 (3): 244–55.
3. Savina M.A. Postinsul'tnye psikhicheskie narusheniia: kliniko-statisticheskie, klinicheskie, kliniko-patogeneticheskie, prognosticheskie aspekty. Dis. ... d-ra med. nauk. Moscow, 2016 (in Russian).
4. Brodaty H, Sachdev PS, Withall A et al. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke – the Sydney stroke study. Psychol Med 2005; 35 (12): 1707–16.
5. Van Dalen JW, Moll van Charante EP, Nederkoorn PJ et al. Poststroke apathy. Stroke 2013; 44 (3): 851–60.
6. Williams LS. What bothers caregivers of stroke victims? J Neuroscience Nursing 2004; 26: 155–161.
7. Petrova E.A. Affektivnye rasstroistva u bol'nykh s tserebral'nym insul'tom. Dis. ... d-ra med. nauk. Moscow, 2013 (in Russian).
8. Reekum R. Apathy: why care? J Neuropsychiatry Clin Neurosci 2005; 17 (1): 7–19.
9. Kutlubaev M.A., Akhmadeeva L.R. Simptomy patologicheskoi ustalosti, apatii i depressii u patsientov posle tserebral'nogo insul'ta. Nevrologiia, neiropsikhiatriia, psikhosomatika. 2015; 7 (2): 16–21 (in Russian).
10. Robinson RG, Jorge RE, Clarence-Smith K, Starkstein S. Double-blind treatment of apathy in patients with poststroke depression using nefiracetam. J Neuropsych Clin Neuroscien 2009; 21 (2): 144–51.
11. Bleuler E. Dementia praecox or the group of schizophrenias. New York: International Universities Press, 1983.
12. Stuss DT, van Reekum R, Murphy KJ. Differentiation of states and causes of apathy. In: Borod J (Ed.) The Neuropsychology of Emotion. New York, Oxford University Press. 2000: p. 340–63.
13. Starkstein SE, Leentjens AF. The nosological position of apathy in clinical practice. J Neurol Neurosurg Psychiatry 2008; 79 (10): 1088–92.
14. Heron CI, Apps MA, Husain M. The anatomy of apathy: a neurocognitive framework for amotivated behaviour. Neuropsychologia 2018; 118: 54–67.
15. Nobis L, Husain М. Apathy in Alzheimer's disease. Curr Opin Behav Sci 2018; 22: 7–13.
16. Zakharov V.V., Voznesenskaia T.G. Neuropsychiatric disorders: diagnostic tests. Moscow: Medpress-inform, 2018 (in Russian).
17. Voznesenskaia T.G. Sindrom apatii. Nevrologicheskii zhurn. 2013; 3: 4–8 (in Russian).
18. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 1991; 3: 243–54.
19. Marin RS, Biedrzycki RC, Firinciogullar S. Reliability and validity of the apathy evaluation scale. Psychiatry Res 1991; 38: 143–62.
20. Marin RS, Wilkosz PA. Disorders of diminished motivation. J Head Trauma Rehabil 2005; 20 (4): 377–88.
21. Marin RS. Differential diagnosis and classification of apathy. Am J Psychiatry 1990; 147: 22–30.
22. Starkstein SE. Apathy and withdrawal. Int Psychogeriatr 2000; 12: 135–8.
23. Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cerebral Cortex 2006; 16: 916–28.
24. Cummings JL, Mega M, Gray K et al. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–14.
25. Starkstein SE, Petracca G, Chemerinski E et al. Syndromic validity of apathy in Alzheimer’s disease. Am J Psychiatry 2001; 158: 872–7.
26. Strauss ME, Sperry SD. An informant-based assessment of apathy in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol 2002; 15 (3): 176–83.
27. Robert PH, Clairet S, Benoit M et al. The apathy inventory: assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. Int J Geriatr Psychiatry 2002; 17 (12): 1099–105.
28. Robert P, Onyike CU, Leentjens AF et al. Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. Eur Psychiatry 2009; 24: 98–104.
29. Mayo NE, Fellows LK, Scott SC et al. A longitudinal view of apathy and its impact after stroke. Stroke 2009; 40: 3299–307.
30. Cameron JI. The impact of stroke survivors' behavioural and psychological symptoms on informal caregivers' mental health. PhD dissertation. University of Toronto Press. 2004: p. 237.
31. Cameron JI, Cheung AM, Streiner DL et al. Stroke survivors' behavioral and psychologic symptoms are associated with informal caregivers' experiences of depression. Arch Physical Med Rehabil 2006; 87: 177–83.
32. Zhao QF, Tan L, Wang HF et al. The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis. J Aff Dis 2016; 190: 264–71.
33. Nodel' M.R., Iakhno N.N. Apatiia pri bolezni Parkinsona. Nevrolog. zhurn. 2014; 1: 9–15 (in Russian).
34. Den Brok MG, van Dalen JW, van Gool WA et al. Apathy in Parkinson's disease: a systematic review and meta-analysis. Mov Dis 2015; 30 (6): 759–69.
35. Clarke DE, van Reekum R, Simard M et al. Apathy in dementia: clinical and sociodemographic correlates. J Neuropsychiatry Clin Neurosci 2008; 20 (3): 337–47.
36. Voznesenskaia T.G. Depression in old age. Consilium Medical. 2000; 11: 74–9 (in Russian).
37. Goldfine АМ, Dehbandi В, Briana S et al. Quantifying post-stroke apathy with actimeters. J Neuropsychiatry Clin Neurosci 2016; 28 (3): 199–204.
38. Petrova E.A., Ponevezhskaia E.V., Savina M.A., Skvortsova V.I. Klinicheskie osobennosti postinsul'tnoi apatii. Zhurn. nevrologii i psikhiatrii im. S.S. Korsakova. 2012; 12: 15–9 (in Russian).
39. Finset A, Andersson S. Coping strategies in patients with acquired brain injury: relationships between coping, apathy, depression and lesion location. Brain Inj 2009; 14 (10): 887–905.
40. Sagen U, Vik TG, Moum T et al. Screening for anxiety and depression after stroke: comparison of the hospital anxiety and depression scale and the Montgomery and Asberg depression rating scale. J Psychosomat Res 2009; 67 (4): 325–32.
41. Harvey PO, Fossati P, Pochon JB et al. Cognitive control and brain resources in major depression. Neuroimage 2005; 26: 860–69.
42. Andersson S, Krogstad JM, Finset A. Apathy and depressed mood in acquired brain damage: relationship to lesion localization and psychophysiological reactivity. Psychol Med 1999; 29: 447–56.
43. Starkstein SE, Fedoroff JP, Price TR et al. Apathy following cerebrovascular lesions. Stroke 1993; 24: 1625–30.
44. Kennedy JM, Dora BS, Granato А, Goldfine AM Natural history of post-stroke apathy during acute rehabilitation. J Neuropsychiatry Clin Neurosci 2015; 27 (4): 333–8.
45. Bogolepova A.N. Depressive disorders in patients with cerebrovascular pathology. Handbook for Practitioners Doctors. 2006; 8 (in Russian).
46. Aharon-Peretz J, Kliot D, Tomer R. Behavioral differences between white matter lacunar dementia and Alzheimer’s disease: a comparison on the neuropsychiatric inventory. Dement Geriatr Cogn Dis 2000; 11: 294–8.
47. McGilchrist I, Goldstein LH, Jadresic D et al. Thalamo-frontal psychosis. Br J Psychiatry 1993; 163: 113–5.
48. Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994; 117: 859–76.
49. Okada K, Kobayashi S, Yamagata S et al. Poststroke apathy and regional cerebral blood flow. Stroke 1997; 28: 2437–41.
50. Parks RW, Crockett DJ, Manji HK et al. Assessment of bromocriptine intervention for the treatment of frontal lobe syndrome: a case study. J Neuropsychiatry Clin Neurosci 1992; 4: 109–11.
51. Watanabe MD, Martin EM, DeLeon OA et al. Successful methylphenidate treatment of apathy after subcortical infarcts. J Neuropsychiatry Clin Neurosci 1995; 7: 502–4.
52. Doody RS, Massman P, Mahurin R et al. Positive and negative neuropsychiatric features in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 1995; 7: 54–60.
53. Galynker I, Ieronimo C, Miner C et al. Methylphenidate treatment of negative symptoms in patients with dementia. J Neuropsychiatry Clin Neurosci 1997; 9: 231–39.
54. Reichman WE, Coyne AC, Amirneni S et al. Negative symptoms in Alzheimer’s disease. Am J Psychiatry 1996; 153: 424–6.
55. Aarsland DА, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson’s disease with dementia and Alzheimer’s disease. Int J Geriatr Psychiatry 2001; 16: 184–91.
56. Paulsen JS, Ready RE, Hamilton JM et al. Neuropsychiatric aspects of Huntington’s disease. J Neuro Neurosurg Psychiatry 2001; 71: 310–4.
57. Narushima K, Robinson RG. The effect of early versus late antidepressant treatment on physical impairment associated with poststroke depression: is there a time-related therapeutic window? J Nerv Ment Dis 2003; 191 (10): 645–52.
58. Rasmussen A, Lunde M, Poulsen DL et al. A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 2003; 44 (3): 216–21.
59. Zhang LS, Hu XY, Yao LY et al. Prophylactic effects of duloxetine on post-stroke depression symptoms: an open single-blind trial. Eur Neurol 2013; 69 (6): 336–43.
60. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
61. Flaster M, Sharma A, Rao M. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery. Top Stroke Rehabil 2013; 20 (2): 139–50.
62. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
63. Hama S, Yamashita H, Shigenobu M et al. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia. Eur Arch Psychiatry Clin Neurosci 2011; 257 (3): 149–52.
64. Santa N, Sugimori H, Kusuda K et al. Apathy and functional recovery following first-ever stroke. Int J Rehabil Res 2008; 31 (4): 321–6.
2. Kim JS Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms. J Stroke 2016; 18 (3): 244–55.
3. Савина М.А. Постинсультные психические нарушения: клинико-статистические, клинические, клинико-патогенетические, прогностические аспекты. Дис. ... д-ра мед. наук. М., 2016.
[Savina M.A. Postinsul'tnye psikhicheskie narusheniia: kliniko-statisticheskie, klinicheskie, kliniko-patogeneticheskie, prognosticheskie aspekty. Dis. ... d-ra med. nauk. Moscow, 2016 (in Russian).]
4. Brodaty H, Sachdev PS, Withall A et al. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke – the Sydney stroke study. Psychol Med 2005; 35 (12): 1707–16.
5. Van Dalen JW, Moll van Charante EP, Nederkoorn PJ et al. Poststroke apathy. Stroke 2013; 44 (3): 851–60.
6. Williams LS. What bothers caregivers of stroke victims? J Neuroscience Nursing 2004; 26: 155–161.
7. Петрова Е.А. Аффективные расстройства у больных с церебральным инсультом. Дис. ... д-ра мед. наук. М., 2013.
[Petrova E.A. Affektivnye rasstroistva u bol'nykh s tserebral'nym insul'tom. Dis. ... d-ra med. nauk. Moscow, 2013 (in Russian).].
8. Reekum R. Apathy: why care? J Neuropsychiatry Clin Neurosci 2005; 17 (1): 7–19.
9. Кутлубаев М.А., Ахмадеева Л.Р. Симптомы патологической усталости, апатии и депрессии у пациентов после церебрального инсульта. Неврология, нейропсихиатрия, психосоматика. 2015; 7 (2): 16–21.
[Kutlubaev M.A., Akhmadeeva L.R. Simptomy patologicheskoi ustalosti, apatii i depressii u patsientov posle tserebral'nogo insul'ta. Nevrologiia, neiropsikhiatriia, psikhosomatika. 2015; 7 (2): 16–21 (in Russian).]
10. Robinson RG, Jorge RE, Clarence-Smith K, Starkstein S. Double-blind treatment of apathy in patients with poststroke depression using nefiracetam. J Neuropsych Clin Neuroscien 2009; 21 (2): 144–51.
11. Bleuler E. Dementia praecox or the group of schizophrenias. New York: International Universities Press, 1983.
12. Stuss DT, van Reekum R, Murphy KJ. Differentiation of states and causes of apathy. In: Borod J (Ed.) The Neuropsychology of Emotion. New York, Oxford University Press. 2000: p. 340–63.
13. Starkstein SE, Leentjens AF. The nosological position of apathy in clinical practice. J Neurol Neurosurg Psychiatry 2008; 79 (10): 1088–92.
14. Heron CI, Apps MA, Husain M. The anatomy of apathy: a neurocognitive framework for amotivated behaviour. Neuropsychologia 2018; 118: 54–67.
15. Nobis L, Husain М. Apathy in Alzheimer's disease. Curr Opin Behav Sci 2018; 22: 7–13.
16. Захаров В.В., Вознесенская Т.Г. Нервно-психические нарушения: диагностические тесты. М.: Медпресс-информ, 2018.
[Zakharov V.V., Voznesenskaia T.G. Neuropsychiatric disorders: diagnostic tests. Moscow: Medpress-inform, 2018 (in Russian).]
17. Вознесенская Т.Г. Синдром апатии. Неврологический журн. 2013; 3: 4–8.
[Voznesenskaia T.G. Sindrom apatii. Nevrologicheskii zhurn. 2013; 3: 4–8 (in Russian).]
18. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 1991; 3: 243–54.
19. Marin RS, Biedrzycki RC, Firinciogullar S. Reliability and validity of the apathy evaluation scale. Psychiatry Res 1991; 38: 143–62.
20. Marin RS, Wilkosz PA. Disorders of diminished motivation. J Head Trauma Rehabil 2005; 20 (4): 377–88.
21. Marin RS. Differential diagnosis and classification of apathy. Am J Psychiatry 1990; 147: 22–30.
22. Starkstein SE. Apathy and withdrawal. Int Psychogeriatr 2000; 12: 135–8.
23. Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cerebral Cortex 2006; 16: 916–28.
24. Cummings JL, Mega M, Gray K et al. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–14.
25. Starkstein SE, Petracca G, Chemerinski E et al. Syndromic validity of apathy in Alzheimer’s disease. Am J Psychiatry 2001; 158: 872–7.
26. Strauss ME, Sperry SD. An informant-based assessment of apathy in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol 2002; 15 (3): 176–83.
27. Robert PH, Clairet S, Benoit M et al. The apathy inventory: assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. Int J Geriatr Psychiatry 2002; 17 (12): 1099–105.
28. Robert P, Onyike CU, Leentjens AF et al. Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. Eur Psychiatry 2009; 24: 98–104.
29. Mayo NE, Fellows LK, Scott SC et al. A longitudinal view of apathy and its impact after stroke. Stroke 2009; 40: 3299–307.
30. Cameron JI. The impact of stroke survivors' behavioural and psychological symptoms on informal caregivers' mental health. PhD dissertation. University of Toronto Press. 2004: p. 237.
31. Cameron JI, Cheung AM, Streiner DL et al. Stroke survivors' behavioral and psychologic symptoms are associated with informal caregivers' experiences of depression. Arch Physical Med Rehabil 2006; 87: 177–83.
32. Zhao QF, Tan L, Wang HF et al. The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis. J Aff Dis 2016; 190: 264–71.
33. Нодель М.Р., Яхно Н.Н. Апатия при болезни Паркинсона. Невролог. журн. 2014; 1: 9–15.
[Nodel' M.R., Iakhno N.N. Apatiia pri bolezni Parkinsona. Nevrolog. zhurn. 2014; 1: 9–15 (in Russian).]
34. Den Brok MG, van Dalen JW, van Gool WA et al. Apathy in Parkinson's disease: a systematic review and meta-analysis. Mov Dis 2015; 30 (6): 759–69.
35. Clarke DE, van Reekum R, Simard M et al. Apathy in dementia: clinical and sociodemographic correlates. J Neuropsychiatry Clin Neurosci 2008; 20 (3): 337–47.
36. Вознесенская Т.Г. Депрессия в пожилом возрасте. Consilium Medical. 2000; 11: 74–9.
[Voznesenskaia T.G. Depression in old age. Consilium Medical. 2000; 11: 74–9 (in Russian).]
37. Goldfine АМ, Dehbandi В, Briana S et al. Quantifying post-stroke apathy with actimeters. J Neuropsychiatry Clin Neurosci 2016; 28 (3): 199–204.
38. Петрова Е.А., Поневежская Е.В., Савина М.А., Скворцова В.И. Клинические особенности постинсультной апатии. Журн. неврологии и психиатрии им. С.С. Корсакова. 2012; 12: 15–9.
[Petrova E.A., Ponevezhskaia E.V., Savina M.A., Skvortsova V.I. Klinicheskie osobennosti postinsul'tnoi apatii. Zhurn. nevrologii i psikhiatrii im. S.S. Korsakova. 2012; 12: 15–9 (in Russian).]
39. Finset A, Andersson S. Coping strategies in patients with acquired brain injury: relationships between coping, apathy, depression and lesion location. Brain Inj 2009; 14 (10): 887–905.
40. Sagen U, Vik TG, Moum T et al. Screening for anxiety and depression after stroke: comparison of the hospital anxiety and depression scale and the Montgomery and Asberg depression rating scale. J Psychosomat Res 2009; 67 (4): 325–32.
41. Harvey PO, Fossati P, Pochon JB et al. Cognitive control and brain resources in major depression. Neuroimage 2005; 26: 860–69.
42. Andersson S, Krogstad JM, Finset A. Apathy and depressed mood in acquired brain damage: relationship to lesion localization and psychophysiological reactivity. Psychol Med 1999; 29: 447–56.
43. Starkstein SE, Fedoroff JP, Price TR et al. Apathy following cerebrovascular lesions. Stroke 1993; 24: 1625–30.
44. Kennedy JM, Dora BS, Granato А, Goldfine AM Natural history of post-stroke apathy during acute rehabilitation. J Neuropsychiatry Clin Neurosci 2015; 27 (4): 333–8.
45. Боголепова А.Н. Депрессивные расстройства у больных с цереброваскулярной патологией. Справочник поликлинического врача. 2006; 8.
[Bogolepova A.N. Depressive disorders in patients with cerebrovascular pathology. Handbook for Practitioners Doctors. 2006; 8 (in Russian).]
46. Aharon-Peretz J, Kliot D, Tomer R. Behavioral differences between white matter lacunar dementia and Alzheimer’s disease: a comparison on the neuropsychiatric inventory. Dement Geriatr Cogn Dis 2000; 11: 294–8.
47. McGilchrist I, Goldstein LH, Jadresic D et al. Thalamo-frontal psychosis. Br J Psychiatry 1993; 163: 113–5.
48. Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994; 117: 859–76.
49. Okada K, Kobayashi S, Yamagata S et al. Poststroke apathy and regional cerebral blood flow. Stroke 1997; 28: 2437–41.
50. Parks RW, Crockett DJ, Manji HK et al. Assessment of bromocriptine intervention for the treatment of frontal lobe syndrome: a case study. J Neuropsychiatry Clin Neurosci 1992; 4: 109–11.
51. Watanabe MD, Martin EM, DeLeon OA et al. Successful methylphenidate treatment of apathy after subcortical infarcts. J Neuropsychiatry Clin Neurosci 1995; 7: 502–4.
52. Doody RS, Massman P, Mahurin R et al. Positive and negative neuropsychiatric features in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 1995; 7: 54–60.
53. Galynker I, Ieronimo C, Miner C et al. Methylphenidate treatment of negative symptoms in patients with dementia. J Neuropsychiatry Clin Neurosci 1997; 9: 231–39.
54. Reichman WE, Coyne AC, Amirneni S et al. Negative symptoms in Alzheimer’s disease. Am J Psychiatry 1996; 153: 424–6.
55. Aarsland DА, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson’s disease with dementia and Alzheimer’s disease. Int J Geriatr Psychiatry 2001; 16: 184–91.
56. Paulsen JS, Ready RE, Hamilton JM et al. Neuropsychiatric aspects of Huntington’s disease. J Neuro Neurosurg Psychiatry 2001; 71: 310–4.
57. Narushima K, Robinson RG. The effect of early versus late antidepressant treatment on physical impairment associated with poststroke depression: is there a time-related therapeutic window? J Nerv Ment Dis 2003; 191 (10): 645–52.
58. Rasmussen A, Lunde M, Poulsen DL et al. A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 2003; 44 (3): 216–21.
59. Zhang LS, Hu XY, Yao LY et al. Prophylactic effects of duloxetine on post-stroke depression symptoms: an open single-blind trial. Eur Neurol 2013; 69 (6): 336–43.
60. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
61. Flaster M, Sharma A, Rao M. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery. Top Stroke Rehabil 2013; 20 (2): 139–50.
62. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
63. Hama S, Yamashita H, Shigenobu M et al. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia. Eur Arch Psychiatry Clin Neurosci 2011; 257 (3): 149–52.
64. Santa N, Sugimori H, Kusuda K et al. Apathy and functional recovery following first-ever stroke. Int J Rehabil Res 2008; 31 (4): 321–6.
________________________________________________
2. Kim JS Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms. J Stroke 2016; 18 (3): 244–55.
3. Savina M.A. Postinsul'tnye psikhicheskie narusheniia: kliniko-statisticheskie, klinicheskie, kliniko-patogeneticheskie, prognosticheskie aspekty. Dis. ... d-ra med. nauk. Moscow, 2016 (in Russian).
4. Brodaty H, Sachdev PS, Withall A et al. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke – the Sydney stroke study. Psychol Med 2005; 35 (12): 1707–16.
5. Van Dalen JW, Moll van Charante EP, Nederkoorn PJ et al. Poststroke apathy. Stroke 2013; 44 (3): 851–60.
6. Williams LS. What bothers caregivers of stroke victims? J Neuroscience Nursing 2004; 26: 155–161.
7. Petrova E.A. Affektivnye rasstroistva u bol'nykh s tserebral'nym insul'tom. Dis. ... d-ra med. nauk. Moscow, 2013 (in Russian).
8. Reekum R. Apathy: why care? J Neuropsychiatry Clin Neurosci 2005; 17 (1): 7–19.
9. Kutlubaev M.A., Akhmadeeva L.R. Simptomy patologicheskoi ustalosti, apatii i depressii u patsientov posle tserebral'nogo insul'ta. Nevrologiia, neiropsikhiatriia, psikhosomatika. 2015; 7 (2): 16–21 (in Russian).
10. Robinson RG, Jorge RE, Clarence-Smith K, Starkstein S. Double-blind treatment of apathy in patients with poststroke depression using nefiracetam. J Neuropsych Clin Neuroscien 2009; 21 (2): 144–51.
11. Bleuler E. Dementia praecox or the group of schizophrenias. New York: International Universities Press, 1983.
12. Stuss DT, van Reekum R, Murphy KJ. Differentiation of states and causes of apathy. In: Borod J (Ed.) The Neuropsychology of Emotion. New York, Oxford University Press. 2000: p. 340–63.
13. Starkstein SE, Leentjens AF. The nosological position of apathy in clinical practice. J Neurol Neurosurg Psychiatry 2008; 79 (10): 1088–92.
14. Heron CI, Apps MA, Husain M. The anatomy of apathy: a neurocognitive framework for amotivated behaviour. Neuropsychologia 2018; 118: 54–67.
15. Nobis L, Husain М. Apathy in Alzheimer's disease. Curr Opin Behav Sci 2018; 22: 7–13.
16. Zakharov V.V., Voznesenskaia T.G. Neuropsychiatric disorders: diagnostic tests. Moscow: Medpress-inform, 2018 (in Russian).
17. Voznesenskaia T.G. Sindrom apatii. Nevrologicheskii zhurn. 2013; 3: 4–8 (in Russian).
18. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 1991; 3: 243–54.
19. Marin RS, Biedrzycki RC, Firinciogullar S. Reliability and validity of the apathy evaluation scale. Psychiatry Res 1991; 38: 143–62.
20. Marin RS, Wilkosz PA. Disorders of diminished motivation. J Head Trauma Rehabil 2005; 20 (4): 377–88.
21. Marin RS. Differential diagnosis and classification of apathy. Am J Psychiatry 1990; 147: 22–30.
22. Starkstein SE. Apathy and withdrawal. Int Psychogeriatr 2000; 12: 135–8.
23. Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cerebral Cortex 2006; 16: 916–28.
24. Cummings JL, Mega M, Gray K et al. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–14.
25. Starkstein SE, Petracca G, Chemerinski E et al. Syndromic validity of apathy in Alzheimer’s disease. Am J Psychiatry 2001; 158: 872–7.
26. Strauss ME, Sperry SD. An informant-based assessment of apathy in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol 2002; 15 (3): 176–83.
27. Robert PH, Clairet S, Benoit M et al. The apathy inventory: assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. Int J Geriatr Psychiatry 2002; 17 (12): 1099–105.
28. Robert P, Onyike CU, Leentjens AF et al. Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. Eur Psychiatry 2009; 24: 98–104.
29. Mayo NE, Fellows LK, Scott SC et al. A longitudinal view of apathy and its impact after stroke. Stroke 2009; 40: 3299–307.
30. Cameron JI. The impact of stroke survivors' behavioural and psychological symptoms on informal caregivers' mental health. PhD dissertation. University of Toronto Press. 2004: p. 237.
31. Cameron JI, Cheung AM, Streiner DL et al. Stroke survivors' behavioral and psychologic symptoms are associated with informal caregivers' experiences of depression. Arch Physical Med Rehabil 2006; 87: 177–83.
32. Zhao QF, Tan L, Wang HF et al. The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis. J Aff Dis 2016; 190: 264–71.
33. Nodel' M.R., Iakhno N.N. Apatiia pri bolezni Parkinsona. Nevrolog. zhurn. 2014; 1: 9–15 (in Russian).
34. Den Brok MG, van Dalen JW, van Gool WA et al. Apathy in Parkinson's disease: a systematic review and meta-analysis. Mov Dis 2015; 30 (6): 759–69.
35. Clarke DE, van Reekum R, Simard M et al. Apathy in dementia: clinical and sociodemographic correlates. J Neuropsychiatry Clin Neurosci 2008; 20 (3): 337–47.
36. Voznesenskaia T.G. Depression in old age. Consilium Medical. 2000; 11: 74–9 (in Russian).
37. Goldfine АМ, Dehbandi В, Briana S et al. Quantifying post-stroke apathy with actimeters. J Neuropsychiatry Clin Neurosci 2016; 28 (3): 199–204.
38. Petrova E.A., Ponevezhskaia E.V., Savina M.A., Skvortsova V.I. Klinicheskie osobennosti postinsul'tnoi apatii. Zhurn. nevrologii i psikhiatrii im. S.S. Korsakova. 2012; 12: 15–9 (in Russian).
39. Finset A, Andersson S. Coping strategies in patients with acquired brain injury: relationships between coping, apathy, depression and lesion location. Brain Inj 2009; 14 (10): 887–905.
40. Sagen U, Vik TG, Moum T et al. Screening for anxiety and depression after stroke: comparison of the hospital anxiety and depression scale and the Montgomery and Asberg depression rating scale. J Psychosomat Res 2009; 67 (4): 325–32.
41. Harvey PO, Fossati P, Pochon JB et al. Cognitive control and brain resources in major depression. Neuroimage 2005; 26: 860–69.
42. Andersson S, Krogstad JM, Finset A. Apathy and depressed mood in acquired brain damage: relationship to lesion localization and psychophysiological reactivity. Psychol Med 1999; 29: 447–56.
43. Starkstein SE, Fedoroff JP, Price TR et al. Apathy following cerebrovascular lesions. Stroke 1993; 24: 1625–30.
44. Kennedy JM, Dora BS, Granato А, Goldfine AM Natural history of post-stroke apathy during acute rehabilitation. J Neuropsychiatry Clin Neurosci 2015; 27 (4): 333–8.
45. Bogolepova A.N. Depressive disorders in patients with cerebrovascular pathology. Handbook for Practitioners Doctors. 2006; 8 (in Russian).
46. Aharon-Peretz J, Kliot D, Tomer R. Behavioral differences between white matter lacunar dementia and Alzheimer’s disease: a comparison on the neuropsychiatric inventory. Dement Geriatr Cogn Dis 2000; 11: 294–8.
47. McGilchrist I, Goldstein LH, Jadresic D et al. Thalamo-frontal psychosis. Br J Psychiatry 1993; 163: 113–5.
48. Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994; 117: 859–76.
49. Okada K, Kobayashi S, Yamagata S et al. Poststroke apathy and regional cerebral blood flow. Stroke 1997; 28: 2437–41.
50. Parks RW, Crockett DJ, Manji HK et al. Assessment of bromocriptine intervention for the treatment of frontal lobe syndrome: a case study. J Neuropsychiatry Clin Neurosci 1992; 4: 109–11.
51. Watanabe MD, Martin EM, DeLeon OA et al. Successful methylphenidate treatment of apathy after subcortical infarcts. J Neuropsychiatry Clin Neurosci 1995; 7: 502–4.
52. Doody RS, Massman P, Mahurin R et al. Positive and negative neuropsychiatric features in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 1995; 7: 54–60.
53. Galynker I, Ieronimo C, Miner C et al. Methylphenidate treatment of negative symptoms in patients with dementia. J Neuropsychiatry Clin Neurosci 1997; 9: 231–39.
54. Reichman WE, Coyne AC, Amirneni S et al. Negative symptoms in Alzheimer’s disease. Am J Psychiatry 1996; 153: 424–6.
55. Aarsland DА, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson’s disease with dementia and Alzheimer’s disease. Int J Geriatr Psychiatry 2001; 16: 184–91.
56. Paulsen JS, Ready RE, Hamilton JM et al. Neuropsychiatric aspects of Huntington’s disease. J Neuro Neurosurg Psychiatry 2001; 71: 310–4.
57. Narushima K, Robinson RG. The effect of early versus late antidepressant treatment on physical impairment associated with poststroke depression: is there a time-related therapeutic window? J Nerv Ment Dis 2003; 191 (10): 645–52.
58. Rasmussen A, Lunde M, Poulsen DL et al. A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 2003; 44 (3): 216–21.
59. Zhang LS, Hu XY, Yao LY et al. Prophylactic effects of duloxetine on post-stroke depression symptoms: an open single-blind trial. Eur Neurol 2013; 69 (6): 336–43.
60. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
61. Flaster M, Sharma A, Rao M. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery. Top Stroke Rehabil 2013; 20 (2): 139–50.
62. Kraglund KL, Mortensen JK, Grove EL et al. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke 2015; 10 (6): 985–7.
63. Hama S, Yamashita H, Shigenobu M et al. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia. Eur Arch Psychiatry Clin Neurosci 2011; 257 (3): 149–52.
64. Santa N, Sugimori H, Kusuda K et al. Apathy and functional recovery following first-ever stroke. Int J Rehabil Res 2008; 31 (4): 321–6.
Авторы
Е.А. Петрова*1, Е.В. Поневежская1, М.А. Савина2, Е.А. Кольцова1
1 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
2 ФГБНУ «Научный центр психического здоровья», Москва, Россия
*633201@mail.ru
1 Pirogov Russian National Research Medical University, Moscow, Russia;
2 Research Center for Mental Health, Moscow, Russia
*633201@mail.ru
1 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
2 ФГБНУ «Научный центр психического здоровья», Москва, Россия
*633201@mail.ru
________________________________________________
1 Pirogov Russian National Research Medical University, Moscow, Russia;
2 Research Center for Mental Health, Moscow, Russia
*633201@mail.ru
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