Бариатрический пациент: основные аспекты подготовки к хирургическому лечению ожирения и ведения после него. Лекция для практических врачей
Бариатрический пациент: основные аспекты подготовки к хирургическому лечению ожирения и ведения после него. Лекция для практических врачей
Ершова Е.В., Комшилова К.А., Мазурина Н.В., Трошина Е.А. Бариатрический пациент: основные аспекты подготовки к хирургическому лечению ожирения и ведения после него. Лекция для практических врачей. Consilium Medicum. 2021; 23 (4): 339–346. DOI: 10.26442/20751753.2021.4.200831
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Ershova EV, Komshilova KA, Mazurina NV, Troshina EA. The bariatric patient: basic aspects preparation for surgical treatment of obesity and conducting after it. Lecture for practitioners. Consilium Medicum. 2021; 23 (4): 339–346. DOI: 10.26442/20751753.2021.4.200831
Бариатрический пациент: основные аспекты подготовки к хирургическому лечению ожирения и ведения после него. Лекция для практических врачей
Ершова Е.В., Комшилова К.А., Мазурина Н.В., Трошина Е.А. Бариатрический пациент: основные аспекты подготовки к хирургическому лечению ожирения и ведения после него. Лекция для практических врачей. Consilium Medicum. 2021; 23 (4): 339–346. DOI: 10.26442/20751753.2021.4.200831
________________________________________________
Ershova EV, Komshilova KA, Mazurina NV, Troshina EA. The bariatric patient: basic aspects preparation for surgical treatment of obesity and conducting after it. Lecture for practitioners. Consilium Medicum. 2021; 23 (4): 339–346. DOI: 10.26442/20751753.2021.4.200831
На протяжении последних лет и десятилетий во всем мире в целом и в России в частности для лечения тяжелых форм ожирения бариатрическая хирургия получает все более широкое распространение, при этом наблюдается как увеличение количества выполняемых операций, так и накопление опыта в отношении их безопасности и эффективности, а также совершенствование хирургических методик. В данной лекции четко обозначены показания и противопоказания к хирургическому лечению ожирения. Описаны различные виды бариатрических операций и патофизиологические механизмы их влияния на массу тела, углеводный и липидный обмен, а также продемонстрирована их эффективность при коморбидной ожирению патологии, в первую очередь у пациентов с сахарным диабетом 2-го типа (СД 2). Продемонстрированы требования к бариатрическим операциям и приведены параметры оценки их эффективности, в том числе ремиссии СД 2. Проанализированы возможные осложнения хирургических методов лечения ожирения, в том числе вторичный гиперпаратиреоз, постбариатрические гипогликемии и другие, а также предикторы послеоперационного прогноза в отношении метаболического контроля у пациентов с ожирением и СД 2.
Ключевые слова: ожирение, сахарный диабет 2-го типа, бариатрические операции
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Over the past years and decades, in the world in general and particularly in Russia, bariatric surgery is becoming more widespread for the treatment of severe forms of obesity. There is an increase in the number of operations performed along with the effectiveness and minimising risks of the operations held due to the improvement of surgical techniques. In this lecture, there are clearly stated indications and contraindications for the surgical treatment of obesity. Here are presented various types of bariatric surgeries and their pathophysiological mechanisms which affect on body weight, carbohydrate and lipid metabolism. There is also presented their effectiveness in comorbid obesity pathology, primarily among patients with type 2 diabetes. Here was held an analysis of possible negative effects after surgical treatment for obesity, including secondary hyperparathyroidism, post-bariatric hypoglycemia, etc., as well as predictors of postoperative prognosis in relation on metabolic control among patients with obesity and type 2 diabetes.
Keywords: obesity, type 2 diabetes mellitus, bariatric surgery
1. Powers P. Conservative treatment for morbid obesity. In: Deitel M. Surgery for the morbidly obese patient. Philadelphia – London, 1989; p. 27-37.
2. American Society for Metabolic and Bariatric Surgery. Available at: https://asmbs.org/.
3. IFSO 2018 23rd World Congress Obesity Surgery. 2018;28(Suppl.2):131-1271.
4. Fried M, Yumuk V, Oppert J, et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. International Federation for the Surgery of Obesity and Metabolic Disorders – European Chapter (IFSO – EC) and European Association for the Study of Obesity (EASO). Obes Surg. 2014;24(1):42-55.
5. Лечение морбидного ожирения. Национальные клинические рекомендации. Ожирение и метаболизм. 2018;1:53-70 [Lechenie morbidnogo ozhireniia. Natsional’nye klinicheskie rekomendatsii. Ozhirenie i metabolizm. 2018;1:53-70 (in Russian)].
6. Дедов И.И., Шестакова М.В., Мельниченко Г.А., и др. Междисциплинарные клинические рекомендации «Лечение ожирения и коморбидных заболеваний». Ожирение и метаболизм. 2021;18(1):5-99 [Dedov II, Shestakova MV, Mel’nichenko GA, et al. Mezhdistsiplinarnye klinicheskie rekomendatsii “Lechenie ozhireniia i komorbidnykh zabolevanii”. Ozhirenie i metabolizm. 2021;18(1):5-99 (in Russian)]. DOI:10.14341/omet12714
7. Koehestanie P, de Jonge C, Berends FJ, et al. The effect of the endoscopic duodenojejunal bypass liner on obesity and diabetes mellitus, a multicenter randomized control trial. Ann Surg. 2014;260:984-92.
8. Яшков Ю.И., Ершова Е.В. «Метаболическая» хирургия. Ожирение и метаболизм. 2011;3:65-8 [Iashkov IuI, Ershova EV. “Metabolicheskaia” khirurgiia. Ozhirenie i metabolizm. 2011;3:65-8 (in Russian)].
9. Flancbaum L. Mechanisms of weight loss after surgery for clinically severe obesity. Obes Surg. 1999;9(6):516-23.
10. Kulick D, Hark L, Deen D. The bariatric surgery patient: a growing role for registered dietitians. J Am Diet Assoc. 2010;110:593-9.
11. Jastrzebska-Mierzyńska M, Ostrowska L, Wasiluk D, Konarzewska-Duchnowska E. Dietetic recommendations after bariatric procedures in the light of the new guidelines regarding metabolic and bariatric surgery. Rocz Panstw Zakl Hig. 2015;66:13-9.
12. Handzlik-Orlik G, Holecki M, Orlik B, et al. Nutrition management of the post-bariatric surgery patient. Nutr Clin Prac. 2015;30(3):383-92.
13. Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient–2013 update. Obesity (Silver Spring). 2013;21(Suppl.1):S1-27.
14. Isom KA, Andromalos L, Ariagno M, et al. Nutrition and metabolic support recommendations for the bariatric patient. Nutr Clin Pract. 2014;29(6):718-39.
15. Aills L, Blankenship J, Buffington C, et al. ASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient. Surg Obes Relat Dis. 2008;4(Suppl.5):S73-108.
16. Dagan S, Goldenshluger A, Globus I, et al. Nutritional recommendations for adult bariatric surgery patients: clinical practice. Adv Nutr. 2017;8(2):382-94.
17. Parikh M, Johnson JM, Ballem N. ASMBS position statement on alcohol use before and after bariatric surgery. Surg Obes Relat Dis. 2016;12(2):225-30.
18. Wee CC, Mukamal KJ, Huskey KW, et al. High-risk alcohol use after weight loss surgery. Surg Obes Relat Dis. 2014;10:508-13.
19. Heneghan HM, Heinberg L, Windover A, et al. Weighing the evidence for an association between obesity and suicide risk. Surg Obes Relat Dis. 2012;8:98-107.
20. Tindle HA, Omalu B, Courcoulas A, et al. Risk of suicide after long-term follow-up from bariatric surgery. Am J Med. 2010;123:1036-42.
21. Chen EY, Fettich KC, McCloskey MS. Correlates of suicidal ideation and/or behavior in bariatric-surgery-seeking individuals with severe obesity. Crisis. 2012;33:137-43.
22. Guelinckx I, Devlieger R, Vansant G. Reproductive outcome after bariatric surgery: a critical review. Hum Reprod Update. 2009;15(2):189-201.
23. Tsur A, Machtinger R, Segal-Lieberman G, et al. Obesity, bariatric surgery and future fertility. Harefuah. 2014;153(8):478-81.
24. Heber D, Greenway F, Kaplan L, et al. Endocrine and nutritional management of the post-bariatric surgery patient: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2010;95(11):4823-43.
25. Busetto L, Dicker D, Azran C, et al. Practical recommendations of the obesity management task force of the European association for the study of obesity for the post-bariatric surgery medical management. Obes Facts. 2017;10:597-632.
26. The American Congress of Obstetricians and Gynecologists (ACOG): ACOG practice bulletin no. 105: bariatric surgery and pregnancy. Obstet Gynecol. 2009;113:1405-13.
27. Kushner RF, Sorensen KW. Prevention of weight regain following bariatric surgery. Curr Obes Rep. 2015;4:198-206.
28. International Diabetes Federation. Available at: https://www.idf.org/
29. Aminian A, Brethauer S, Andalib A, et al. Individualized metabolic surgery score: procedure selection based on diabetes severity. Ann Surg. 2017;266(4):650-7.
30. Raveendran AV, Shiji PV, Pappachan JM. Role of bariatric surgery in type 2 diabetes. BMH Med J. 2017;4(1):6-16.
31. American Diabetes Association. Diabetes Care. 2021;44(Suppl.1):S73-84. DOI:10.2337/dc21-S006
32. Patti ME, Goldfine AB, Hu J, et al. Heterogeneity of proliferative markers in pancreatic β-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. Acta Diabetol. 2017;54(8):737-47. DOI:10.1007/s00592-017-1001-2
33. Вaggio L, Drucker D. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131-57.
34. Holst J. On the physiology of GIP and GLP-1. Horm Metab Res. 2004;36:747-54.
35. Rabiee A, Magruder J, Salas-Carrillo R, et al. Hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: Unraveling the roles of gut hormonal and pancreatic endocrine dysfunction. J Surg Res. 2011;167:199-205.
36. Salehi M, Gastaldelli A, D’Alessio DA. Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia. J Clin Endocrinol Metab. 2014;99(6):2008-17. DOI:10.1210/jc.2013-2686
37. Abrahamsson N, Borjesson JL, Sundbom M, et al. Gastric bypass reduces symptoms and hormonal responses in hypoglycemia. Diabetes. 2016;9:2667-75.
38. Salehi M, Woods SC, D’Alessio DA. Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion. Obesity (Silver Spring). 2015;10:2046-52.
39. Kellogg TA, Bantle JP, Leslie DB, et al. Postgastric bypass hyperinsulinemic hypoglycemia syndrome: characterization and response to a modified diet. Surg Obes Relat Dis. 2008;4(4):492-9. DOI:10.1016/j.soard.2008.05.005
40. Goldfine AB, Mun EC, Devine E, et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab. 2007;92(12):4678-85.
41. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122:249-61.
42. Musella М, Susa A, Manno E, et al. Complications Following the Mini/One Anastomosis Gastric Bypass (MGB/OAGB): a Multi-institutional Survey on 2678 Patients with a Mid-term (5 Years) Follow-up. Obesity Surgery. 2017;11(27):2956-67.
43. Dindo D, Demartines S, Clavien P. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205-13.
44. Parrott J, Frank L, Rabena R, et al. American Society for Metabolic and Bariatric Surgery integrated health nutritional guidelines for the surgical weight loss patient 2016 Update: micronutrients. Surg Obes Relat Dis. 2017;13:727-41.
________________________________________________
1. Powers P. Conservative treatment for morbid obesity. In: Deitel M. Surgery for the morbidly obese patient. Philadelphia – London, 1989; p. 27-37.
2. American Society for Metabolic and Bariatric Surgery. Available at: https://asmbs.org/.
3. IFSO 2018 23rd World Congress Obesity Surgery. 2018;28(Suppl.2):131-1271.
4. Fried M, Yumuk V, Oppert J, et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. International Federation for the Surgery of Obesity and Metabolic Disorders – European Chapter (IFSO – EC) and European Association for the Study of Obesity (EASO). Obes Surg. 2014;24(1):42-55.
5. Лечение морбидного ожирения. Национальные клинические рекомендации. Ожирение и метаболизм. 2018;1:53-70 [Lechenie morbidnogo ozhireniia. Natsional’nye klinicheskie rekomendatsii. Ozhirenie i metabolizm. 2018;1:53-70 (in Russian)].
6. Дедов И.И., Шестакова М.В., Мельниченко Г.А., и др. Междисциплинарные клинические рекомендации «Лечение ожирения и коморбидных заболеваний». Ожирение и метаболизм. 2021;18(1):5-99 [Dedov II, Shestakova MV, Mel’nichenko GA, et al. Mezhdistsiplinarnye klinicheskie rekomendatsii “Lechenie ozhireniia i komorbidnykh zabolevanii”. Ozhirenie i metabolizm. 2021;18(1):5-99 (in Russian)]. DOI:10.14341/omet12714
7. Koehestanie P, de Jonge C, Berends FJ, et al. The effect of the endoscopic duodenojejunal bypass liner on obesity and diabetes mellitus, a multicenter randomized control trial. Ann Surg. 2014;260:984-92.
8. Яшков Ю.И., Ершова Е.В. «Метаболическая» хирургия. Ожирение и метаболизм. 2011;3:65-8 [Iashkov IuI, Ershova EV. “Metabolicheskaia” khirurgiia. Ozhirenie i metabolizm. 2011;3:65-8 (in Russian)].
9. Flancbaum L. Mechanisms of weight loss after surgery for clinically severe obesity. Obes Surg. 1999;9(6):516-23.
10. Kulick D, Hark L, Deen D. The bariatric surgery patient: a growing role for registered dietitians. J Am Diet Assoc. 2010;110:593-9.
11. Jastrzebska-Mierzyńska M, Ostrowska L, Wasiluk D, Konarzewska-Duchnowska E. Dietetic recommendations after bariatric procedures in the light of the new guidelines regarding metabolic and bariatric surgery. Rocz Panstw Zakl Hig. 2015;66:13-9.
12. Handzlik-Orlik G, Holecki M, Orlik B, et al. Nutrition management of the post-bariatric surgery patient. Nutr Clin Prac. 2015;30(3):383-92.
13. Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient–2013 update. Obesity (Silver Spring). 2013;21(Suppl.1):S1-27.
14. Isom KA, Andromalos L, Ariagno M, et al. Nutrition and metabolic support recommendations for the bariatric patient. Nutr Clin Pract. 2014;29(6):718-39.
15. Aills L, Blankenship J, Buffington C, et al. ASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient. Surg Obes Relat Dis. 2008;4(Suppl.5):S73-108.
16. Dagan S, Goldenshluger A, Globus I, et al. Nutritional recommendations for adult bariatric surgery patients: clinical practice. Adv Nutr. 2017;8(2):382-94.
17. Parikh M, Johnson JM, Ballem N. ASMBS position statement on alcohol use before and after bariatric surgery. Surg Obes Relat Dis. 2016;12(2):225-30.
18. Wee CC, Mukamal KJ, Huskey KW, et al. High-risk alcohol use after weight loss surgery. Surg Obes Relat Dis. 2014;10:508-13.
19. Heneghan HM, Heinberg L, Windover A, et al. Weighing the evidence for an association between obesity and suicide risk. Surg Obes Relat Dis. 2012;8:98-107.
20. Tindle HA, Omalu B, Courcoulas A, et al. Risk of suicide after long-term follow-up from bariatric surgery. Am J Med. 2010;123:1036-42.
21. Chen EY, Fettich KC, McCloskey MS. Correlates of suicidal ideation and/or behavior in bariatric-surgery-seeking individuals with severe obesity. Crisis. 2012;33:137-43.
22. Guelinckx I, Devlieger R, Vansant G. Reproductive outcome after bariatric surgery: a critical review. Hum Reprod Update. 2009;15(2):189-201.
23. Tsur A, Machtinger R, Segal-Lieberman G, et al. Obesity, bariatric surgery and future fertility. Harefuah. 2014;153(8):478-81.
24. Heber D, Greenway F, Kaplan L, et al. Endocrine and nutritional management of the post-bariatric surgery patient: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2010;95(11):4823-43.
25. Busetto L, Dicker D, Azran C, et al. Practical recommendations of the obesity management task force of the European association for the study of obesity for the post-bariatric surgery medical management. Obes Facts. 2017;10:597-632.
26. The American Congress of Obstetricians and Gynecologists (ACOG): ACOG practice bulletin no. 105: bariatric surgery and pregnancy. Obstet Gynecol. 2009;113:1405-13.
27. Kushner RF, Sorensen KW. Prevention of weight regain following bariatric surgery. Curr Obes Rep. 2015;4:198-206.
28. International Diabetes Federation. Available at: https://www.idf.org/
29. Aminian A, Brethauer S, Andalib A, et al. Individualized metabolic surgery score: procedure selection based on diabetes severity. Ann Surg. 2017;266(4):650-7.
30. Raveendran AV, Shiji PV, Pappachan JM. Role of bariatric surgery in type 2 diabetes. BMH Med J. 2017;4(1):6-16.
31. American Diabetes Association. Diabetes Care. 2021;44(Suppl.1):S73-84. DOI:10.2337/dc21-S006
32. Patti ME, Goldfine AB, Hu J, et al. Heterogeneity of proliferative markers in pancreatic β-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. Acta Diabetol. 2017;54(8):737-47. DOI:10.1007/s00592-017-1001-2
33. Вaggio L, Drucker D. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131-57.
34. Holst J. On the physiology of GIP and GLP-1. Horm Metab Res. 2004;36:747-54.
35. Rabiee A, Magruder J, Salas-Carrillo R, et al. Hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: Unraveling the roles of gut hormonal and pancreatic endocrine dysfunction. J Surg Res. 2011;167:199-205.
36. Salehi M, Gastaldelli A, D’Alessio DA. Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia. J Clin Endocrinol Metab. 2014;99(6):2008-17. DOI:10.1210/jc.2013-2686
37. Abrahamsson N, Borjesson JL, Sundbom M, et al. Gastric bypass reduces symptoms and hormonal responses in hypoglycemia. Diabetes. 2016;9:2667-75.
38. Salehi M, Woods SC, D’Alessio DA. Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion. Obesity (Silver Spring). 2015;10:2046-52.
39. Kellogg TA, Bantle JP, Leslie DB, et al. Postgastric bypass hyperinsulinemic hypoglycemia syndrome: characterization and response to a modified diet. Surg Obes Relat Dis. 2008;4(4):492-9. DOI:10.1016/j.soard.2008.05.005
40. Goldfine AB, Mun EC, Devine E, et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab. 2007;92(12):4678-85.
41. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122:249-61.
42. Musella М, Susa A, Manno E, et al. Complications Following the Mini/One Anastomosis Gastric Bypass (MGB/OAGB): a Multi-institutional Survey on 2678 Patients with a Mid-term (5 Years) Follow-up. Obesity Surgery. 2017;11(27):2956-67.
43. Dindo D, Demartines S, Clavien P. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205-13.
44. Parrott J, Frank L, Rabena R, et al. American Society for Metabolic and Bariatric Surgery integrated health nutritional guidelines for the surgical weight loss patient 2016 Update: micronutrients. Surg Obes Relat Dis. 2017;13:727-41.