Витамины группы В и заболевания нервной системы

1. Lopatina T, Kalinina N, Karagyaur M, et al. Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One. 2011;6:e17899.
2. Sun H, Yang T, Li Q, et al. Dexamethasone and vitamin B(12) synergistically promote peripheral nerve regeneration in rats by upregulating the expression of brain-derived neurotrophic factor. Arch Med Sci. 2012;8:924-30.
3. Sun Y, Lai M, Lu C. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwanica. 2005;14(2):48-54.
4. Hendrawati YD, Andrajati R, Supardi S, et al. The risk of cobalamin deficiency symptoms related to long-term metformin use in T2DM patients. Acta Endocrinol (Buchar). 2018;14(1):49-54. DOI:10.4183/aeb.2018.49
5. Супонева Н.А., Гришина Д.А., Легостаева Л.А., Мочалова Е.Г. Хроническая интоксикация «веселящим газом» (закисью азота) – причина В12-дефицитной миелополинейропатии у лиц молодого возраста. Нервно-мышечные болезни. 2016;6(4):37-45 [Suponeva NA, Grishina DA, Legostaeva LA, Mochalova EG. Chronic intoxication with “laughing gas” (nitrous oxide) as a cause of B12 deficiency myelopolyneuropathy in young adults. Neuromuscular Diseases. 2016;6(4):37-45 (in Russian)]. DOI:10.17650/2222-8721-2016-6-4-37-45
6. Andrès E, Affenberger S, Vinzio S, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med. 2005;118(10):1154-9. DOI:10.1016/j.amjmed.2005.02.026
7. Lam J, Schneider J, Zhao W, Corley D. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013;310(22):2435-42. DOI:10.1001/jama.2013.280490
8. Mahajan A, Sapehia D, Thakur S, et al. Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs. Sci Rep. 2019;26;9(1):м17602. DOI:10.1038/s41598-019-54070-9
9. Sonobe M, Yasuda H, Hatanaka I, et al. Methylcobalamin Improves Nerve Conduction in Streptozotocin-Diabetic Rats Without Affecting Sorbitol and Myo-Inositol Contents of Sciatic Nerve. Horm Metab Res. 1988;20(11):717-8. DOI:10.1055/s-2007-1010925
10. Watanabe T, Kaji R, Oka N, et al. Ultrahigh dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci. 1994;122(2):140-3. DOI:10.1016/0022-510x(94)90290-9
11. Jacobs A, Cheng D. Management of diabetic small fiber neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5`-phosphate. Rev Neurol Dis. 2011;8(1-2):39-47.
12. Okada K, Tanaka H, Temporin K, et al. Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol. 2010;222(2):191-203. DOI:10.1016/j.expneurol.2009.12.017
13. Mizukami H, Ogasawara S, Yamagishi S, et al. Methylcobalamin Effects on Diabetic Neuropathy and Nerve Protein Kinase C in Rats. Eur J Clin Invest. 2011;41(4):442-50. DOI:10.1111/j.1365-2362.2010.02430.x
14. Токмакова А.Ю., Анциферов М.Б. Возможности использования Нейромультивита в комплексной терапии полинейропатии у больных сахарным диабетом. Сахарный диабет. 2001;2(7):33-6 [Tokmakova AYu, Antsiferov MB. Possibilities of using Neuromultivit in the complex therapy of polyneuropathy in patients with diabetes mellitus. Diabetes. 2001;2(7):33-6 (in Russian)].
15. Чухловина М.Л., Чухловин А.А. Особенности диагностики и лечения диабетической полинейропатии у пациентов старших возрастных групп. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(6):42-6 [Chukhlovina ML, Chukhlovin AA. Features of diagnosis and treatment of diabetic polyneuropathy in patients of older age groups. Journal of Neurology and Psychiatry SS Korsakov. 2019;119(6):42-6 (in Russian)].
16. Farvid MS, Homayouni F, Amiri Z, Adelmanesh F. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract. 2011;93:86-94. DOI:10.1016/j.diabres.2011.03.016
17. Верткин А.Л., Данилов А.Б., Мкртумян А.М. Консенсус по ведению больных с диабетической нейропатией в общей врачебной практике. М., 2017 [Vertkin AL, Danilov AB, Mkrtumian AM. Konsensus po vedeniiu bol'nykh s diabeticheskoi neyropatiyei v obshchei vrachebnoi praktike. Moscow, 2017 (in Russian)].
18. Давыдов О.С., Яхно Н.Н., Кукушкин М.Л., и др. Невропатическая боль: клинические рекомендации по диагностике и лечению Российского общества по изучению боли. Российский журнал боли. 2018;58(4):5-41 [Davydov OS, Yakhno NN, Kukushkin ML, et al. Neuropathic pain: clinical recommendations for diagnosis and treatment from The Russian Society for the Study of Pain. Russian Journal of Pain. 2018;58(4):5-41 (in Russian)].
19. Abdu N, Mosazghi A, Teweldemedhin S, et al. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study. PLoS One. 2020;15(10):e0238868. DOI:10.1371/journal.pone.0238868 
20. Swart F, Bianchi G, Lenzi J, et al. Risk of hospitalization from drug-drug interactions in the Elderly: real-world evidence in a large administrative database. Aging (Albany NY). 2020;12(19):19711-39. DOI:10.18632/aging.104018
21. Mibielli M, Geller M, Cohen J, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: The DOLOR study. Curr Med Res Opin. 2009;25(11):2589-99. DOI:10.3111/13696990903246911
22. Левин О.С., Мосейкин И.А. Комплекс витаминов группы В (Мильгамма) в лечении дискогенной пояснично-крестцовой радикулопатии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2009;109(10):30-5 [Levin OS, Moseikin IA. Vitamin B complex (Milgamma) for the treatment of vertebrogenic lumbosacral radiculopathy. Journal of Neurology and Psychiatry S.S. Korsakov. 2009;109(10):30-5 (in Russian)].
23. Бойко А.Н., Батышева Т.Т., Камчатнов П.Р., и др. Нейродикловит: возможность применения у пациентов с болью в спине. Фарматека. 2010;7(201):63-9 [Boiko AN, Batysheva TT, Kamchatnov PR, et al. Neirodiklovit: vozmozhnost' primeneniia u pacientov s bol'iu v spine. Farmateka. 2010;7(201):63-9 (in Russian)].
24. Батышева Т.Т., Бойко А.Н., Камчатнов П.Р., и др. Результаты изучения эффективности применения комбинации препаратов артрозан и комбилипен у пациентов с острой болью в нижней части спины. Журнал неврологии и психиатрии им. С.С. Корсакова. 2011;108(8):67-71 [Batysheva TT, Boyko AN, Kamchatnov PR, et al. Results of the study of the effectiveness of the combination of drugs arthrosan and combilipen in patients with acute lower back pain. Journal of Neurology and Psychiatry SS Korsakov. 2011;108(8):67-71 (in Russian)].
25. Хабиров Ф.А., Хайбуллин Т.И., Гранатов Е.В. Эффективность и безопасность Нейромультивита при вертеброгенных радикулопатиях. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(10):38-43 [Khabirov FA, Khaybullin TI, Granatov EV. Efficacy and safety of Neuromultivitis in vertebrogenic radiculopathies. Journal of Neurology and Psychiatry SS Korsakov. 2017;117(10):38-43 (in Russian)].
26. Ковальчук В.В. Комбинированные препараты: возможность повышения эффективности и безопасности традиционной терапии боли в спине. Эффективная фармакотерапия. 2017;19:80-8 [Kovalchuk VV. Combined diseases: the likelihood of occurrence and safety of treatment for back pain. Effective Pharmacotherapy. 2017;19:80-8 (in Russian)].
27. Данилов А.Б. Применение витаминов группы В при болях в спине: новые анальгетики? РМЖ. 2008;16:35-9 [Danilov AB. The use of B vitamins for back pain: new analgesics? RMZh. 2008;16:35-9 (in Russian)].
28. Bruggemann G, Koehler CO, Koch EM. Results of double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study. Klin Wochenschr. 1990;19:116-20.
29. Данилов А.Б. Витамины группы «В» в лечении боли. Manage Pain. 2016;4:31-4 [Danilov AB. Vitamins of group "B" in the treatment of pain. Manage Pain. 2016;4:31-4 (in Russian)].
30. Geller M. Comparison of the action of diclofenac alone versus diclofenac plus B vitamins on mobility in patients with low back pain. Journal of Drug Assessment. 2016;5(1):1-3.
31. Calderon-Ospina CA, Nava-Mesa MO, Arbeláez Ariza CE. Effect of combined Diclofenac and B vitamins (thiamine, pyridoxine, and cyanocobalamin) for low back pain management: systematic review and meta-analysis. Pain Medicine. 2020;21(4):766-81.
32. Камчатнов П.Р. Повышение эффективности и безопасности лечения пациентов с поясничной болью. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(10):28-33 [Kamchatnov PR. Improving the effectiveness and safety of treatment of patients with lumbar pain. Journal of Neurology and Psychiatry S.S. Korsakov. 2016;116(10):28-33 (in Russian)]. DOI:10.17116/jnevro201611610128-33 15
33. Парфенов В.А., Яхно Н.Н., Давыдов О.С., и др. Хроническая неспецифическая (скелетно-мышечная) поясничная боль. Рекомендации Российского общества по изучению боли (РОИБ). Неврология, нейропсихиатрия, психосоматика. 2019;11(Спецвып. 2):7-16 [Parfenov VA, Yakhno NN, Davydov OS, et al. Chronic nonspecific (musculoskeletal) lumbar pain. Recommendations of the Russian Society for the Study of Pain (ROIB). Neurology, Neuropsychiatry, Psychosomatics. 2019;11 (Special Issue 2):7-16 (in Russian)]. DOI:10.14412/2074-2711-2019-2S-7-16
34. Wang L, Niu H, Zhang J. Homocysteine induces mitochondrial dysfunction and oxidative stress in myocardial ischemia/reperfusion injury through stimulating ROS production and the ERK1/2 signaling pathway. Exp Ther Med. 2020;20(2):938-44. DOI:10.3892/etm.2020.8735
35. Lai W, Kan M. Homocysteine induced endothelial dysfunction. Ann Nutr Metab. 2015;67:1-12. DOI:10.1159/000437098
36. Жетишев Р.Р., Петренко Н.В., Михайлова Н.А. Патоморфологические особенности и факторы риска асимптомного инфаркта головного мозга по данным секционного госпитального исследования. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;3(2):18-23 [Zhetishev RR, Petrenko NV, Mikhailova NA. Pathomorphological features and risk factors of asymptomatic cerebral infarction according to sectional hospital study. Journal of Neurology and Psychiatry S.S. Korsakov. 2016;3(2):18-23 (in Russian)]. DOI:10.17116/jnevro20161163218-22 
37. Pacheco-Quinto J, Rodriguez de Turco E, Derosa S, et al. Hyperhomocysteinemic Alzheimer’s mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiol Dis. 2006;22:651-6. DOI:10.1016/j.nbd.2006.01.005
38. Tawfik A, Samra Y, Elsherbiny N, Al-Shabrawey M. Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction. Biomolecules. 2020;10(8):1119-26. DOI:10.3390/biom10081119
39. Miwa K, Tanaka M, Okazaki S, et al. Increased total homocysteine levels predict the risk of incident dementia independent of cerebral small-vessel diseases and vascular risk factors. J Alzheimers Dis. 2015;49:503-13. DOI:10.3233/JAD-150458
40. Jatoi S, Hafeez A, Riaz S. Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus. 2020;12(2):e6976. DOI:10.7759/cureus.6976
41. Smith D, Refsum H. Homocysteine, B Vitamins and Cognitive Impairment. Annu Rev Nutr. 2016;36:211-39. DOI:10.1146/annurev-nutr-071715-050947
42. Smith AD, Smith SM, de Jager CA, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5(9):e12244. DOI:10.1371/journal.pone.0012244
43. Aisen PS, Schneider LS, Sano M, et al. High Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer’s Disease: A Randomized Controlled Trial. JAMA. 2008;300(15):1774-83. DOI:10.1001/jama.300.15.1774
44. Perła-Kaján J, Włoczkowska O, Zioła-Frankowska A, et al. Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment. J Alzheimers Dis. 2021;81(3):1211-29. DOI:10.3233/JAD-210137
45. Greenberg DA, Aminoff MJ, Simon RP. Clinical Neurology. Fifth edition. Chapter 1: Disorders of Consciousness. New York etc.: Lange Medical Books/McGraw-Hill, 2002; p. 1-70.
46. Kwok T, Wu Y, Lee J, et al. A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients. Clin Nutr. 2020;39(8):2399-405. DOI:10.1016/j.clnu.2019.11.005
47. Ford AH, Almeida O. Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis. Drugs Aging. 2019;36(5):419-34. DOI:10.1007/s40266-019-00649-w
48. Smith AD, Refsum H, Bottiglieri T, et al. Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018;62(2):561-70. DOI:10.3233/JAD-171042
49. Супонева Н.А., Гришина Д.А. Применение витамина B12 у онкологических больных. Журнал неврологии и психиатрии им. С.С. Корсакова. 2022;122(4):1-5 [Suponeva NA, Grishina DA. The use of vitamin B12 in cancer patients. Journal of Neurology and Psychiatry S.S. Korsakov. 2022;122(4):1-5 (in Russian)]. DOI:10.17116/jnevro20221220411
50. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer. 2021;21(1):982. DOI:10.1186/s12885-021-08721-8
51. Luu HN, Wang R, Jin A, et al. The association between dietary vitamin B12 and lung cancer risk: findings from a prospective cohort study. Eur J Cancer Prev. 2021;30(3):275-81. DOI:10.1097/CEJ.0000000000000660
52. Bironzo P, Scagliotti GV. Pemetrexed, Vitamin B12, and Thoracic Tumors: The Times, They Are A-Changin’. Clin Lung Cancer. 2018;19(6):461-3. DOI:10.1016/j.cllc.2018.07.007

________________________________________________

1. Lopatina T, Kalinina N, Karagyaur M, et al. Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One. 2011;6:e17899.
2. Sun H, Yang T, Li Q, et al. Dexamethasone and vitamin B(12) synergistically promote peripheral nerve regeneration in rats by upregulating the expression of brain-derived neurotrophic factor. Arch Med Sci. 2012;8:924-30.
3. Sun Y, Lai M, Lu C. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwanica. 2005;14(2):48-54.
4. Hendrawati YD, Andrajati R, Supardi S, et al. The risk of cobalamin deficiency symptoms related to long-term metformin use in T2DM patients. Acta Endocrinol (Buchar). 2018;14(1):49-54. DOI:10.4183/aeb.2018.49
5. Suponeva NA, Grishina DA, Legostaeva LA, Mochalova EG. Chronic intoxication with “laughing gas” (nitrous oxide) as a cause of B12 deficiency myelopolyneuropathy in young adults. Neuromuscular Diseases. 2016;6(4):37-45 (in Russian). DOI:10.17650/2222-8721-2016-6-4-37-45
6. Andrès E, Affenberger S, Vinzio S, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med. 2005;118(10):1154-9. DOI:10.1016/j.amjmed.2005.02.026
7. Lam J, Schneider J, Zhao W, Corley D. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013;310(22):2435-42. DOI:10.1001/jama.2013.280490
8. Mahajan A, Sapehia D, Thakur S, et al. Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs. Sci Rep. 2019;26;9(1):м17602. DOI:10.1038/s41598-019-54070-9
9. Sonobe M, Yasuda H, Hatanaka I, et al. Methylcobalamin Improves Nerve Conduction in Streptozotocin-Diabetic Rats Without Affecting Sorbitol and Myo-Inositol Contents of Sciatic Nerve. Horm Metab Res. 1988;20(11):717-8. DOI:10.1055/s-2007-1010925
10. Watanabe T, Kaji R, Oka N, et al. Ultrahigh dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci. 1994;122(2):140-3. DOI:10.1016/0022-510x(94)90290-9
11. Jacobs A, Cheng D. Management of diabetic small fiber neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5`-phosphate. Rev Neurol Dis. 2011;8(1-2):39-47.
12. Okada K, Tanaka H, Temporin K, et al. Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol. 2010;222(2):191-203. DOI:10.1016/j.expneurol.2009.12.017
13. Mizukami H, Ogasawara S, Yamagishi S, et al. Methylcobalamin Effects on Diabetic Neuropathy and Nerve Protein Kinase C in Rats. Eur J Clin Invest. 2011;41(4):442-50. DOI:10.1111/j.1365-2362.2010.02430.x
14. Tokmakova AYu, Antsiferov MB. Possibilities of using Neuromultivit in the complex therapy of polyneuropathy in patients with diabetes mellitus. Diabetes. 2001;2(7):33-6 (in Russian).
15. Chukhlovina ML, Chukhlovin AA. Features of diagnosis and treatment of diabetic polyneuropathy in patients of older age groups. Journal of Neurology and Psychiatry SS Korsakov. 2019;119(6):42-6 (in Russian).
16. Farvid MS, Homayouni F, Amiri Z, Adelmanesh F. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract. 2011;93:86-94. DOI:10.1016/j.diabres.2011.03.016
17. Vertkin AL, Danilov AB, Mkrtumian AM. Konsensus po vedeniiu bol'nykh s diabeticheskoi neyropatiyei v obshchei vrachebnoi praktike. Moscow, 2017 (in Russian).
18. Davydov OS, Yakhno NN, Kukushkin ML, et al. Neuropathic pain: clinical recommendations for diagnosis and treatment from The Russian Society for the Study of Pain. Russian Journal of Pain. 2018;58(4):5-41 (in Russian).
19. Abdu N, Mosazghi A, Teweldemedhin S, et al. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study. PLoS One. 2020;15(10):e0238868. DOI:10.1371/journal.pone.0238868 
20. Swart F, Bianchi G, Lenzi J, et al. Risk of hospitalization from drug-drug interactions in the Elderly: real-world evidence in a large administrative database. Aging (Albany NY). 2020;12(19):19711-39. DOI:10.18632/aging.104018
21. Mibielli M, Geller M, Cohen J, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: The DOLOR study. Curr Med Res Opin. 2009;25(11):2589-99. DOI:10.3111/13696990903246911
22. Levin OS, Moseikin IA. Vitamin B complex (Milgamma) for the treatment of vertebrogenic lumbosacral radiculopathy. Journal of Neurology and Psychiatry S.S. Korsakov. 2009;109(10):30-5 (in Russian).
23. Boiko AN, Batysheva TT, Kamchatnov PR, et al. Neirodiklovit: vozmozhnost' primeneniia u pacientov s bol'iu v spine. Farmateka. 2010;7(201):63-9 (in Russian).
24. Batysheva TT, Boyko AN, Kamchatnov PR, et al. Results of the study of the effectiveness of the combination of drugs arthrosan and combilipen in patients with acute lower back pain. Journal of Neurology and Psychiatry SS Korsakov. 2011;108(8):67-71 (in Russian).
25. Khabirov FA, Khaybullin TI, Granatov EV. Efficacy and safety of Neuromultivitis in vertebrogenic radiculopathies. Journal of Neurology and Psychiatry SS Korsakov. 2017;117(10):38-43 (in Russian).
26. Kovalchuk VV. Combined diseases: the likelihood of occurrence and safety of treatment for back pain. Effective Pharmacotherapy. 2017;19:80-8 (in Russian).
27. Danilov AB. The use of B vitamins for back pain: new analgesics? RMZh. 2008;16:35-9 (in Russian).
28. Bruggemann G, Koehler CO, Koch EM. Results of double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study. Klin Wochenschr. 1990;19:116-20.
29. Danilov AB. Vitamins of group "B" in the treatment of pain. Manage Pain. 2016;4:31-4 (in Russian).
30. Geller M. Comparison of the action of diclofenac alone versus diclofenac plus B vitamins on mobility in patients with low back pain. Journal of Drug Assessment. 2016;5(1):1-3.
31. Calderon-Ospina CA, Nava-Mesa MO, Arbeláez Ariza CE. Effect of combined Diclofenac and B vitamins (thiamine, pyridoxine, and cyanocobalamin) for low back pain management: systematic review and meta-analysis. Pain Medicine. 2020;21(4):766-81.
32. Kamchatnov PR. Improving the effectiveness and safety of treatment of patients with lumbar pain. Journal of Neurology and Psychiatry S.S. Korsakov. 2016;116(10):28-33 (in Russian). DOI:10.17116/jnevro201611610128-33 15
33. Parfenov VA, Yakhno NN, Davydov OS, et al. Chronic nonspecific (musculoskeletal) lumbar pain. Recommendations of the Russian Society for the Study of Pain (ROIB). Neurology, Neuropsychiatry, Psychosomatics. 2019;11 (Special Issue 2):7-16 (in Russian). DOI:10.14412/2074-2711-2019-2S-7-16
34. Wang L, Niu H, Zhang J. Homocysteine induces mitochondrial dysfunction and oxidative stress in myocardial ischemia/reperfusion injury through stimulating ROS production and the ERK1/2 signaling pathway. Exp Ther Med. 2020;20(2):938-44. DOI:10.3892/etm.2020.8735
35. Lai W, Kan M. Homocysteine induced endothelial dysfunction. Ann Nutr Metab. 2015;67:1-12. DOI:10.1159/000437098
36. Zhetishev RR, Petrenko NV, Mikhailova NA. Pathomorphological features and risk factors of asymptomatic cerebral infarction according to sectional hospital study. Journal of Neurology and Psychiatry S.S. Korsakov. 2016;3(2):18-23 (in Russian). DOI:10.17116/jnevro20161163218-22 
37. Pacheco-Quinto J, Rodriguez de Turco E, Derosa S, et al. Hyperhomocysteinemic Alzheimer’s mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiol Dis. 2006;22:651-6. DOI:10.1016/j.nbd.2006.01.005
38. Tawfik A, Samra Y, Elsherbiny N, Al-Shabrawey M. Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction. Biomolecules. 2020;10(8):1119-26. DOI:10.3390/biom10081119
39. Miwa K, Tanaka M, Okazaki S, et al. Increased total homocysteine levels predict the risk of incident dementia independent of cerebral small-vessel diseases and vascular risk factors. J Alzheimers Dis. 2015;49:503-13. DOI:10.3233/JAD-150458
40. Jatoi S, Hafeez A, Riaz S. Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus. 2020;12(2):e6976. DOI:10.7759/cureus.6976
41. Smith D, Refsum H. Homocysteine, B Vitamins and Cognitive Impairment. Annu Rev Nutr. 2016;36:211-39. DOI:10.1146/annurev-nutr-071715-050947
42. Smith AD, Smith SM, de Jager CA, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5(9):e12244. DOI:10.1371/journal.pone.0012244
43. Aisen PS, Schneider LS, Sano M, et al. High Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer’s Disease: A Randomized Controlled Trial. JAMA. 2008;300(15):1774-83. DOI:10.1001/jama.300.15.1774
44. Perła-Kaján J, Włoczkowska O, Zioła-Frankowska A, et al. Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment. J Alzheimers Dis. 2021;81(3):1211-29. DOI:10.3233/JAD-210137
45. Greenberg DA, Aminoff MJ, Simon RP. Clinical Neurology. Fifth edition. Chapter 1: Disorders of Consciousness. New York etc.: Lange Medical Books/McGraw-Hill, 2002; p. 1-70.
46. Kwok T, Wu Y, Lee J, et al. A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients. Clin Nutr. 2020;39(8):2399-405. DOI:10.1016/j.clnu.2019.11.005
47. Ford AH, Almeida O. Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis. Drugs Aging. 2019;36(5):419-34. DOI:10.1007/s40266-019-00649-w
48. Smith AD, Refsum H, Bottiglieri T, et al. Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018;62(2):561-70. DOI:10.3233/JAD-171042
49. Suponeva NA, Grishina DA. The use of vitamin B12 in cancer patients. Journal of Neurology and Psychiatry S.S. Korsakov. 2022;122(4):1-5 (in Russian). DOI:10.17116/jnevro20221220411
50. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer. 2021;21(1):982. DOI:10.1186/s12885-021-08721-8
51. Luu HN, Wang R, Jin A, et al. The association between dietary vitamin B12 and lung cancer risk: findings from a prospective cohort study. Eur J Cancer Prev. 2021;30(3):275-81. DOI:10.1097/CEJ.0000000000000660
52. Bironzo P, Scagliotti GV. Pemetrexed, Vitamin B12, and Thoracic Tumors: The Times, They Are A-Changin’. Clin Lung Cancer. 2018;19(6):461-3. DOI:10.1016/j.cllc.2018.07.007

П.Р. Камчатнов*, А.В. Чугунов, А.А. Кабанов

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*pavkam7@gmail.com

________________________________________________

Pavel R. Kamchatnov*, Alexandr V. Chugunov, Alexey A. Kabanov

Pirogov Russian National Research Medical University, Moscow, Russia
*pavkam7@gmail.com