Атопические заболевания и онкопатология. Что общего?

Устименко В.И., Логвиненко Н.И. Атопические заболевания и онкопатология. Что общего? Consilium Medicum. 2022;24(12):894–898. DOI: 10.26442/20751753.2022.12.201949

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Ustimenko VI, Logvinenko NI. Atopic diseases and oncopathology. What do they have in common? A review. Consilium Medicum. 2022;24(12):894–898. DOI: 10.26442/20751753.2022.12.201949

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Аннотация

Увеличение распространенности онкологических заболеваний во всем мире повлияло на интерес исследователей к поиску факторов, которые могут запускать онкогенез. Существует актуальный вопрос, аллергические заболевания вызывают рак или предотвращают его? Были проведены многочисленные исследования, в которых оценивались связи между аллергическими заболеваниями и возникновением рака различных локализаций. Результаты противоречивы как в характере течения заболевания, так и в локализации возникновения рака. В связи с этим предложены 2 основные теории: теория иммунного надзора и теория воспаления. В данном обзоре проведен анализ современных научных работ с целью оценки частоты возникновения новообразований на фоне атопических заболеваний. Проведенный анализ клинических исследований свидетельствует о противоречивых результатах ассоциации аллергических и онкологических заболеваний. Ряд исследований показал обратную связь между атопическими заболеваниями и риском возникновения рака, что подтверждает теорию иммунного надзора [опухоль головного мозга (глиома), рак поджелудочной железы, колоректальный рак, неходжкинская лимфома, рак молочной железы, рак полости рта и глотки, гортани]. В то же время в ряде исследований отмечена положительная связь между атопическими и онкологическими заболеваниями, что подтверждает теорию хронического воспаления (рак легких и колоректальный рак в сочетании с бронхиальной астмой). Отсутствие однозначного объяснения взаимосвязи аллергии и онкологических заболеваний свидетельствует об актуальности проведения долгосрочных проспективных исследований, направленных на изучение факторов риска развития рака в сочетании с атопическими заболеваниями, с последующей разработкой рискометров с целью стратификации пациентов, скрининга, разработки программ раннего выявления и новых подходов к лечению злокачественных новообразований.

Ключевые слова: атопические заболевания, онкологические заболевания, аллергия, бронхиальная астма, аллергоонкология, иммунитет

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The increasing prevalence of cancer worldwide has influenced the interest of researchers to search for factors that may trigger oncogenesis in order to prevent and treat cancer. There is a burning question, can allergic diseases cause or prevent cancer? Numerous epidemiological studies have been conducted that have evaluated aspects of the relationship between allergic diseases and the occurrence of cancers of various localizations. The results of most of these studies are inconsistent, both in the nature of the course of the disease and in the variety of localizations of the occurrence of cancer. In this connection, two basic theories were suggested: the theory of immune surveillance and the theory of inflammation. This review analyzed current scientific work to estimate the incidence of neoplasms against the background of atopic diseases. The analysis of clinical studies shows inconsistent results of the association between allergic diseases and cancer. Several studies an inverse relationship between atopic diseases and cancer risk, which supports the theory of immune surveillance [brain tumor (glioma), pancreatic cancer, colorectal cancer, non-Hodgkin's lymphoma, and breast cancer, cancer of the mouth and throat, larynx]. At the same time, a number of studies note a positive association between atopic diseases and cancer, which confirms the theory of chronic inflammation (lung cancer and colorectal cancer combined with bronchial asthma). The lack of an unequivocal explanation testifies to the urgency of long-term prospective studies aimed at studying the risk factors of cancer in combination with atopic diseases with the subsequent development of risk scale for the purpose of patient stratification, screening, development of early detection programs and new approaches to the treatment of malignant neoplasms.

Key words: atopic diseases, oncological diseases, allergy, bronchial asthma, allergooncology, immunity

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Список литературы

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27. Kantor ED, Hsu M, Du M, Signorello LB. Allergies and asthma in relation to cancer risk. Cancer Epidemiol Biomarkers Prev. 2019;28(8):1395-403. DOI:10.1158/1055-9965.EPI-18-1330
28. Santillan AA, Camargo CA Jr, Colditz GA. A meta-analysis of asthma and risk of lung cancer (United States). Cancer Causes Control. 2003;14(4):327-34. DOI:10.1023/a:1023982402137
29. Rosenberger A, Bickeböller H, McCormack V, et al. Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium. Carcinogenesis. 2012;33(3):587-97. DOI:10.1093/carcin/bgr307
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32. Mansfield KE, Schmidt SAJ, Darvalics B, et al. Association between atopic eczema and cancer in England and Denmark. JAMA Dermatol. 2020;156(10):1086-97. DOI:10.1001/jamadermatol.2020.1948
33. Linabery AM, Prizment AE, Anderson KE, et al. Allergic diseases and risk of hematopoietic malignancies in a cohort of postmenopausal women: a report from the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2014;23(9):1903-12. DOI:10.1158/1055-9965.EPI-14-0423

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1. Chang VC, Cotterchio M, De P, Tinmouth J. Risk factors for early-onset colorectal cancer: a population-based case-control study in Ontario, Canada. Cancer Causes Control. 2021;32(10):1063-83. DOI:10.1007/s10552-021-01456-8
2. Kozłowska R, Bożek A, Jarząb J. Association between cancer and allergies. Allergy, Asthma Clin Immunol. 2016;12(1):39. DOI:10.1186/s13223-016-0147-8
3. Pampura AN. Development of pediatric allergology: Problems and prospects. Russian Bulletin of Perinatology and Pediatrics. 2015;60(1):7-15 (in Russian).
4. Carneiro BGMC, Petroianu A, Machado JAN, et al. Clinical and immunological allergy assessment in cancer patients. Sci Rep. 2021;11(1):18110. DOI:10.1038/s41598-021-97200-y
5. McCraw AJ, Chauhan J, Bax HJ, et al. Insights from IgE immune surveillance in allergy and cancer for anti-tumour IgE treatments. Cancers (Basel). 2021;13(17):4460. DOI:10.3390/cancers13174460
6. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. DOI:10.3322/caac.21660
7. Schwartzbaum J, Ding B, Johannesen TB, et al. Association between prediagnostic IgE levels and risk of glioma. J Natl Cancer Inst. 2012;104(16):1251-9. DOI:10.1093/jnci/djs315
8. Ma W, Yang J, Li P, et al. Association between allergic conditions and colorectal cancer risk/mortality: a meta-analysis of prospective studies. SciRep. 2017;7(1):5589. DOI:10.1038/s41598-017-04772-9
9. Tambe NA, Wilkens LR, Wan P, et al. Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study. Am J Epidemiol. 2015;181(11):889-97. DOI:10.1093/aje/kwu361
10. Engkilde K, Thyssen JP, Menné T, Johansen JD. Association between cancer and contact allergy: a linkage study. BMJ Open. 2011;1(1):e000084. DOI:10.1136/bmjopen-2011-000084
11. Turner MC, Chen Y, Krewski D, et al. Cancer mortality among US men and women with asthma and hay fever. Am J Epidemiol. 2005;162(3):212-21. DOI:10.1093/aje/kwi193
12. Chou WY, Lai PY, Hu JM, et al. Association between atopic dermatitis and colorectal cancer risk: A nationwide cohort study. Medicine (Baltimore). 2020;99(1):e18530. DOI:10.1097/MD.0000000000018530
13. Ye J, Talaiti A, Ma Y, et al. Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies. Oncotarget. 2017;8(9):14646-54. DOI:10.18632/oncotarget.14599
14. Rava M, Czachorowski MJ, Silverman D, et al. Asthma status is associated with decreased risk of aggressive urothelial bladder cancer. Int J Cancer. 2018;142(3):470-6. DOI:10.1002/ijc.31066
15. Turner MC, Chen Y, Krewski D, Ghadirian P. An overview of the association between allergy and cancer. Int J Cancer. 2006;118(12):3124-32. DOI:10.1002/ijc.21752
16. Michaud DS, Langevin SM, Eliot M, et al. Allergies and risk of head and neck cancer. Cancer Causes Control. 2012;23(8):1317-22. DOI:10.1007/s10552-012-0009-8
17. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30. DOI:10.3322/caac.21590
18. Huang BZ, Le Marchand L, Haiman CA, et al. Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study. Int J Cancer. 2018;142(10):2019-27. DOI:10.1002/ijc.31241
19. Wang G, Xu Z, Zhu J, et al. Decreased risk in the pancreatic cancer with history of hay fever: A meta-analysis. Front Public Heal. 2020;8(1):7-30. DOI:10.3389/fpubh.2020.551490
20. Cotterchio M, Lowcock E, Hudson TJ, et al. Association between allergies and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2014;23(3):469-80.
DOI:10.1158/1055-9965.EPI-13-0965
21. Zhu J, Song J, Liu Z, et al. Association between allergic conditions and risk of prostate cancer: A prisma-compliant systematic review and meta-analysis. Sci Rep. 2016;6(1):35682. DOI:10.1038/srep35682
22. Wang H, Rothenbacher D, Löw M, et al. Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum. Int J Cancer. 2006;119(3):695-701. DOI:10.1002/ijc.21883
23. Vojtechova P, Martin RM. The association of atopic diseases with breast, prostate, and colorectal cancers: a meta-analysis. Cancer Causes Control. 2009;20(7):1091-105. DOI:10.1007/s10552-009-9334-y
24. Qu YL, Liu J, Zhang LX, et al. Asthma and the risk of lung cancer: a meta-analysis. Oncotarget. 2017;8(7):11614-20. DOI:10.18632/oncotarget.14595
25. Rosenberger A, Bickeböller H, McCormack V, et al. Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium. Carcinogenesis. 2012;33(3):587-97. DOI:10.1093/carcin/bgr307
26. Jiang L, Sun YQ, Langhammer A, et al. Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study. Sci Rep. 2021;11(1):4539. DOI:10.1038/s41598-021-84012-3
27. Kantor ED, Hsu M, Du M, Signorello LB. Allergies and asthma in relation to cancer risk. Cancer Epidemiol Biomarkers Prev. 2019;28(8):1395-403. DOI:10.1158/1055-9965.EPI-18-1330
28. Santillan AA, Camargo CA Jr, Colditz GA. A meta-analysis of asthma and risk of lung cancer (United States). Cancer Causes Control. 2003;14(4):327-34. DOI:10.1023/a:1023982402137
29. Rosenberger A, Bickeböller H, McCormack V, et al. Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium. Carcinogenesis. 2012;33(3):587-97. DOI:10.1093/carcin/bgr307
30. Bożek A, Jarzab J, Mielnik M, et al. Can atopy have a protective effect against cancer? PLoS One. 2020;15(2):e0226950. DOI:10.1371/journal.pone.0226950
31. Vajdic CM, Falster MO, de Sanjose S, et al. Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis. Cancer Res. 2009;69(16):6482-9.
DOI:10.1158/0008-5472.CAN-08-4372
32. Mansfield KE, Schmidt SAJ, Darvalics B, et al. Association between atopic eczema and cancer in England and Denmark. JAMA Dermatol. 2020;156(10):1086-97. DOI:10.1001/jamadermatol.2020.1948
33. Linabery AM, Prizment AE, Anderson KE, et al. Allergic diseases and risk of hematopoietic malignancies in a cohort of postmenopausal women: a report from the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2014;23(9):1903-12. DOI:10.1158/1055-9965.EPI-14-0423

Авторы

В.И. Устименко*, Н.И. Логвиненко

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России, Новосибирск, Россия
*valeriya.slesarenko@inbox.ru

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Valeriya I. Ustimenko*, Nadezhda I. Logvinenko

Novosibirsk State Medical University, Novosibirsk, Russia
*valeriya.slesarenko@inbox.ru

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