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Актуальные вопросы профилактики рака желудка
Актуальные вопросы профилактики рака желудка
Успенский Ю.П., Барышникова Н.В., Краснов А.А., Петленко С.В., Апрятина В.А. Актуальные вопросы профилактики рака желудка. Consilium Medicum. 2022;24(5):358–364.
DOI: 10.26442/20751753.2022.5.201922
© ООО «КОНСИЛИУМ МЕДИКУМ», 2022 г.
DOI: 10.26442/20751753.2022.5.201922
© ООО «КОНСИЛИУМ МЕДИКУМ», 2022 г.
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Аннотация
Профилактика рака желудка, как первичная, так и вторичная, является крайне важным компонентом ведения пациентов гастроэнтерологического профиля. Весьма актуальны правильный сбор анамнеза с оценкой вероятности развития наследственного (семейного) рака, устранение факторов риска (нарушенное питание, привычные/хронические интоксикации, ожирение, инфекция Helicobacter pylori и другие), а также применение гастропротекторов (в частности, препарата Регастим Гастро), особенно у лиц с потенциально предраковым состоянием – хроническим атрофическим гастритом. По данным двойного слепого плацебо-контролируемого рандомизированного исследования препарата Регастим Гастро (действующее вещество – альфа-глутамил триптофан) в терапии хронического атрофического гастрита установлено, что этот препарат обладает мощным противовоспалительным действием и регенераторной активностью. Прием препарата Регастим Гастро по сравнению с плацебо статистически значимо способствовал снижению количества клеток воспалительной инфильтрации на 1 мм2 слизистой оболочки желудка. В большей степени Регастим Гастро способствовал уменьшению эозинофильной (в 3 раза) и нейтрофильной (в 4 раза) инфильтрации слизистой оболочки желудка. Он также снижал количество макрофагов, лимфоцитов и плазмоцитов. Помимо противовоспалительных свойств препарат оказывал выраженный регенераторный эффект. На фоне приема Регастим Гастро имело место статистически значимое (р=0,028) увеличение количества желез на 1 мм2 слизистой оболочки желудка – на 26,1% в сравнении с исходными показателями скрининга. В группе пациентов, принимавших плацебо, напротив, отмечалось прогрессирование патологического процесса, сопровождавшееся снижением количества желез на 1 мм2 слизистой оболочки желудка после окончания лечения в сравнении с исходными показателями. После курса терапии у пациентов, принимавших препарат Регастим Гастро количество желез на 1 мм2 слизистой оболочки желудка было статистически значимо больше в сравнении с результатами в группе принимавших плацебо (р=0,013). Вследствие комплексного воздействия препарата отмечалось улучшение функциональных параметров слизистой оболочки желудка. После курса Регастим Гастро отмечалось улучшение кислотопродукции: смещение в кислую сторону среднего значения рН (в 1,6 раза) и повышение значения индекса кислотности как при сравнении с исходными значениями (в 5,4 раза), так и в сравнении с группой принимавших плацебо (в 2,9 раза). Назначение Регастим Гастро пациентам с гастритом, как H. pylori (+), так и H. pylori (-), еще до развития атрофии слизистой оболочки желудка с целью уменьшения фактора воспаления и предупреждения возникновения атрофии может иметь максимальную антиканцерогенную активность.
Ключевые слова: атрофия, рак желудка, гастропротекторы, альфа-глутамил-триптофан
Keywords: atrophy, stomach cancer, gastroprotectors, alpha-glutamyl-tryptophan
Ключевые слова: атрофия, рак желудка, гастропротекторы, альфа-глутамил-триптофан
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Keywords: atrophy, stomach cancer, gastroprotectors, alpha-glutamyl-tryptophan
Полный текст
Список литературы
1. Первичная профилактика рака – первая линия обороны в противораковой борьбе. Режим доступа: https://rosoncoweb.ru/library/another/004.pdf. Ссылка активна на 09.09.2022 [Pervichnaia profilaktika raka – pervaia liniia oborony v protivorakovoi bor'be. Available at: https://rosoncoweb.ru/library/another/004.pdf. Accessed: 09.09.2022 (in Russian)].
2. Roser M, Ritchie H. Cancer. Available at: https://ourworldindata.org/cancer. Accessed: 09.09.2022.
3. Herrera V, Parsonnet J. Helicobacter pylori and gastric adenocarcinoma. Clin Microbiol Infect. 2009;15(11):971-6. DOI:10.1111/j.1469-0691.2009.03031.x
4. Бордин Д.С. Рак желудка: на что обратить внимание врачу первичного звена? Лечащий врач. 2022. Режим доступа: https://www.lvrach.ru/articles/15438338?ysclid=l8blqxl25u937289776. Ссылка активна на 09.09.2022 [Bordin DS. Rak zheludka: na chto obratit' vnimanie vrachu pervichnogo zvena? Lechashchii vrach. 2022. Available at: https://www.lvrach.ru/articles/15438338?ysclid=l8blqxl25u93728977. Accessed: 09.09.2022 (in Russian)].
5. World Cancer Report. Available at: https://www.iarc.who.int/featured-news/new-world-cancer-report/ Accessed: 09.09.2022.
6. Заридзе Д.Г. Эпидемиология и этиология злокачественных заболеваний. Канцерогенез. М.: Научный мир, 2000, с. 26-30, 34-56 [Zaridze DG. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 26-30, 34-56 (in Russian)].
7. Копнин Б.П. Опухолевые супрессоры и мутаторные гены. Канцерогенез. М.: Научный мир, 2000, с. 86-87 [Kopnin BP. Opukholevye supressory i mutatornye geny. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 86-87 (in Russian)].
8. Черноусов А.Ф., Поликарпов С.А., Годжело Э.А. Ранний рак и предопухолевые заболевания желудка. М.: ИздАТ, 2002 [Chernousov AF, Polikarpov SA, Godzhelo EA. Rannii rak i predopukholevye zabolevaniia zheludka. Moscow: IzdAT, 2002 (in Russian)].
9. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3(4):219-25. DOI:10.1007/pl00011720
10. Сельчук В.Ю., Никулин М.П. Рак желудка. РМЖ. 2003;26:1441 [Sel'chuk VIu, Nikulin MP. Rak zheludka. RMZh. 2003;26:1441 (in Russian)].
11. Прохоров А.В., Лабунец И.Н., Короткевич П.Е., Гедревич З.Э. Рак желудка: учебно-методическое пособие. Минск: БГМУ, 2021 [Prokhorov AV, Labunets IN, Korotkevich PE, Gedrevich ZE. Rak zheludka: uchebno-metodicheskoe posobie. Minsk: BGMU, 2021 (in Russian)].
12. Peng WJ, Jia XJ, Wei BG, et al. Stomach cancer mortality among workers exposed to asbestos: a meta-analysis. J Cancer Res Clin Oncol. 2015;141(7):1141-9.
DOI:10.1007/s00432-014-1791-3
13. Welling R, Beaumont JJ, Petersen SJ, et al. Chromium VI and stomach cancer: a metaanalysis of the current epidemiological evidence. Occup Environ Med. 2015;72(2):151-9. DOI:10.1136/oemed-2014-102178
14. Yaghoobi M, Bijarchi R, Narod SA. Family history and the risk of gastric cancer. Br J Cancer. 2010;102(2):237-42. DOI:10.1038/sj.bjc.6605380
15. van der Post RS, Vogelaar IP, Carneiro F, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 2015;52(6):361-74. DOI:10.1136/jmedgenet-2015-103094
16. Lunet N, Valbuena C, Vieira AL, et al. Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 2007;16(4):312-27. DOI:10.1097/01.cej.0000236255.95769.22
17. Huang Y, Chen H, Zhou L, et al. Association between green tea intake and risk of gastric cancer: a systematic review and dose-response meta-analysis of observational studies. Public Health Nutr. 2017;20(17):3183-92. DOI:10.1017/S1368980017002208
18. Kim SR, Kim K, Lee SA, et al. Effect of Red, Processed, and White Meat Consumption on the Risk of Gastric Cancer: An Overall and Dose-Response Meta-Analysis. Nutrients. 2019;11(4):826. DOI:10.3390/nu11040826
19. Buckland G, Travier N, Huerta JM, et al. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study. Int J Cancer. 2015;137(3):598-606. DOI:10.1002/ijc.29411
20. Fang X, Wei J, He X, et al. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer. 2015;51(18):2820-32. DOI:10.1016/j.ejca.2015.09.010
21. Ferro A, Rosato V, Rota M, et al. Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project. Int J Cancer. 2020;147(1):45-55. DOI:10.1002/ijc.32707
22. González CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(5):345-54. DOI:10.1093/jnci/djj071
23. Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open. 2017;7(10):e017739. DOI:10.1136/bmjopen-2017-017739
24. Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut. 2018;67(1):28-35. DOI:10.1136/gutjnl-2017-314605
25. Suissa S, Suissa A. Proton-pump inhibitors and increased gastric cancer risk: time-related biases. Gut. 2018;67(12):2228-9. DOI:10.1136/gutjnl-2017-315729
26. Waldum HL, Sandvik AK, Brenna E, Petersen H. Gastrin-histamine sequence in the regulation of gastric acid secretion. Gut. 1991;32(6):698-701. DOI:10.1136/gut.32.6.698
27. Berlin RG. Omeprazole. Gastrin and gastric endocrine cell data from clinical studies. Dig Dis Sci. 1991;36(2):129-36. DOI:10.1007/BF01300745
28. Kidd M, Tang LH, Modlin IM, et al. Gastrin-mediated alterations in gastric epithelial apoptosis and proliferation in a mastomys rodent model of gastric neoplasia. Digestion. 2000;62(2-3):143-51. DOI:10.1159/000007806
29. Ho AC, Horton KM, Fishman EK. Gastric carcinoid tumors as a consequence of chronic hypergastrinemia: spiral CT findings. Clin Imaging. 2000;24(4):200-3.
DOI:10.1016/s0899-7071(00)00199-6
30. Henwood M, Clarke PA, Smith AM, Watson SA. Expression of gastrin in developing gastric adenocarcinoma. Br J Surg. 2001;88(4):564-8. DOI:10.1046/j.1365-2168.2001.01716.x
31. Dockray GJ, Varro A, Dimaline R, Wang T. The gastrins: their production and biological activities. Annu Rev Physiol. 2001;63:119-39. DOI:10.1146/annurev.physiol.63.1.119
32. Риск развития злокачественных новообразований у больных, получающих ингибиторы протонной помпы. Режим доступа: https://rosoncoweb.ru/news/oncology/2016/01/27/ Ссылка активна на 09.09.2022 [Risk razvitiia zlokachestvennykh novoobrazovanii u bol'nykh, poluchaiushchikh ingibitory protonnoi pompy. Available at: https://rosoncoweb.ru/news/oncology/2016/01/27/ Accessed: 09.09.2022 (in Russian)].
33. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334(16):1018-22. DOI:10.1056/NEJM199604183341603
34. Moayyedi P, Wason C, Peacock R, et al. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter. 2000;5(4):206-14.
DOI:10.1046/j.1523-5378.2000.00032.x
35. Lundell L, Havu N, Miettinen P, et al. Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial. Aliment Pharmacol Ther. 2006;23(5):639-47. DOI:10.1111/j.1365-2036.2006.02792.x
36. González CA, Pera G, Agudo A, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003;107(4):629-34. DOI:10.1002/ijc.11426
37. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 83: Tobacco Smoke and Involuntary Smoking. Lyon: International Agency for Research on Cancer, 2004. Available at: https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono83-1.pdf. Accessed: 09.09.2022.
38. Rota M, Pelucchi C, Bertuccio P, et al. Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium. Int J Cancer. 2017;141(10):1950-62. DOI:10.1002/ijc.30891
39. Ma K, Baloch Z, He TT, Xia X. Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis. Med Sci Monit. 2017;23:238-46. DOI:10.12659/msm.899423
40. Tavakoli A, Monavari SH, Solaymani Mohammadi F, et al. Association between Epstein–Barr virus infection and gastric cancer: a systematic review and meta-analysis. BMC Cancer. 2020;20(1):493. DOI:10.1186/s12885-020-07013-x
41. Cárdenas-Mondragón MG, Torres J, Flores-Luna L, et al. Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease. Br J Cancer. 2015;112(12):1866-73. DOI:10.1038/bjc.2015.175
42. Dávila-Collado R, Jarquín-Durán O, Dong LT, Espinoza JL. Epstein–Barr Virus and Helicobacter Pylori Co-Infection in Non-Malignant Gastroduodenal Disorders. Pathogens. 2020;9(2):104. DOI:10.3390/pathogens9020104
43. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
44. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol. 1995;19(Suppl. 1):S37-43.
45. Correa P. Gastric cancer: overview. Gastroenterol Clin North Am. 2013;42(2):211-7. DOI:10.1016/j.gtc.2013.01.002
46. de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607-15. DOI:10.1016/S1470-2045(12)70137-7
47. Ekström AM, Held M, Hansson LE, et al. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology. 2001;121(4):784-91. DOI:10.1053/gast.2001.27999
48. Mitchell H, English DR, Elliott F, et al. Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer. Aliment Pharmacol Ther. 2008;28(7):903-10. DOI:10.1111/j.1365-2036.2008.03792.x
49. Brenner H, Arndt V, Stegmaier C, et al. Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer? Am J Epidemiol. 2004;159(3):252-8. DOI:10.1093/aje/kwh039
50. Shakeri R, Malekzadeh R, Nasrollahzadeh D, et al. Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas. Cancer Res. 2015;75(22):4876-83. DOI:10.1158/0008-5472.CAN-15-0556
51. Simán JH, Engstrand L, Berglund G, et al. Helicobacter pylori and CagA seropositivity and its association with gastric and oesophageal carcinoma. Scand J Gastroenterol. 2007;42(8):933-40. DOI:10.1080/00365520601173863
52. Kong YJ, Yi HG, Dai JC, Wei MX. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis. World J Gastroenterol. 2014;20(19):5903-11. DOI:10.3748/wjg.v20.i19.5903
53. Chen HN, Wang Z, Li X, Zhou ZG. Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis. Gastric Cancer. 2016;19(1):166-75. DOI:10.1007/s10120-015-0462-7
54. Ивашкин В.Т., Маев И.В., Лапина Т.Л., и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2018;28(1):55-70 [Ivashkin VT, Mayev IV, Lapina TL, et al. Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(1):55-70 (in Russian)]. DOI:10.22416/1382-4376-2018-28-1-55-70
55. Лазебник Л.Б., Ткаченко Е.И., Абдулганиева Д.И., и др. VI Национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helicobacter pylori заболеваний (VI Московские соглашения). Экспериментальная и клиническая гастроэнтерология. 2017;2:3-21 [Lazebnik LB, Tkachenko EI, Abdulganiyeva DI, et al. VI National guidelines for the diagnosis and treatment of acid-related and Helicobacter Pylori-Associated diseases (VI Moscow agreement). Experimental and Clinical Gastroenterology. 2017;2:3-21 (in Russian)].
56. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64(9):1353-67. DOI:10.1136/gutjnl-2015-309252
57. Kodama M, Murakami K, Okimoto T, et al. Helicobacter pylori eradication improves gastric atrophy and intestinal metaplasia in long-term observation. Digestion. 2012;85(2):126-30. DOI:10.1159/000334684
58. Poorolajal J, Moradi L, Mohammadi Y, et al. Risk factors for stomach cancer: a systematic review and meta-analysis. Epidemiol Health. 2020;42:e2020004. DOI:10.4178/epih.e2020004
59. Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012;17(7):2383-90. DOI:10.2741/4059
60. Harvey AE, Lashinger LM, Hursting SD. The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci. 2011;1229:45-52.
DOI:10.1111/j.1749-6632.2011.06096.x
61. Mohammadi M. Role of Obesity in the Tumorigenesis of Gastric Cancer. Int J Prev Med. 2020;11:148. DOI:10.4103/ijpvm.IJPVM_153_19
62. Hursting SD, Berger NA. Energy balance, host-related factors, and cancer progression. J Clin Oncol. 2010;28(26):4058-65. DOI:10.1200/JCO.2010.27.9935
63. Stewart OA, Wu F, Chen Y. The role of gastric microbiota in gastric cancer. Gut Microbes. 2020;11(5):1220-30. DOI:10.1080/19490976.2020.1762520
64. Dai D, Yang Y, Yu J, et al. Interactions between gastric microbiota and metabolites in gastric cancer. Cell Death Dis. 2021;12(12):1104. DOI:10.1038/s41419-021-04396-y
65. Bessède E, Mégraud F. Microbiota and gastric cancer. Semin Cancer Biol. 2022;86(Pt. 3):11-7. DOI:10.1016/j.semcancer.2022.05.001
66. Aviles-Jimenez F, Vazquez-Jimenez F, Medrano-Guzman R, et al. Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer. Sci Rep. 2014;4:4202. DOI:10.1038/srep04202
67. Eun CS, Kim BK, Han DS, et al. Differences in gastric mucosal microbiota profiling in patients with chronic gastritis, intestinal metaplasia, and gastric cancer using pyrosequencing methods. Helicobacter. 2014;19(6):407-16. DOI:10.1111/hel.12145
68. Castaño-Rodríguez N, Goh KL, Fock KM, et al. Dysbiosis of the microbiome in gastric carcinogenesis. Sci Rep. 2017;7(1):15957. DOI:10.1038/s41598-017-16289-2
69. Sonveaux P, Copetti T, De Saedeleer CJ, et al. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PLoS One. 2012;7(3):e33418. DOI:10.1371/journal.pone.0033418
70. Berry D, Reinisch W. Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases? Best Pract Res Clin Gastroenterol. 2013;27(1):47-58. DOI:10.1016/j.bpg.2013.03.005
71. Wang L, Zhou J, Xin Y, et al. Bacterial overgrowth and diversification of microbiota in gastric cancer. Eur J Gastroenterol Hepatol. 2016;28(3):261-6. DOI:10.1097/MEG.0000000000000542
72. Бакулин И.Г., Пирогов С.С., Бакулина Н.В., и др. Профилактика и ранняя диагностика рака желудка. Доказательная гастроэнтерология. 2018;7(2):44-58 [Bakulin IG, Pirogov SS, Bakulina NV, et al. Prophylaxis and early diagnosis of stomach cancer. Dokazatel'naya gastroenterologiya. 2018;7(2):44-58 (in Russian)]. DOI:10.17116/dokgastro201872244
73. Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol. 2015;29(6):895-905. DOI:10.1016/j.bpg.2015.09.013
74. Lee S, Jun JK, Suh M, et al. Gastric cancer screening uptake trends in Korea: results for the National Cancer Screening Program from 2002 to 2011: a prospective cross-sectional study. Medicine (Baltimore). 2015;94(8):e533. DOI:10.1097/MD.0000000000000533
75. Kim GH, Liang PS, Bang SJ, Hwang JH. Screening and surveillance for gastric cancer in the United States: Is it needed? Gastrointest Endosc. 2016;84(1):18-28. DOI:10.1016/j.gie.2016.02.028
76. Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. DOI:10.1586/egh.10.25
77. Haruma K, Ito M. Review article: clinical significance of mucosal- protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther. 2003;18(Suppl. 1):153-9. DOI:10.1046/j.1365-2036.18. s1.17.x
78. Hayashi S, Sugiyama T, Amano K, et al. Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells. Antimicrob Agents Chemother. 1998;42(8):1895-9. DOI:10.1128/AAC.42.8.1895
79. Haruma K, Ito M, Kido S, et al. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis. Dig Dis Sci. 2002;47(4):862-7. DOI:10.1023/a:1014716822702
80. Kamada T, Sato M, Tokutomi T, et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study. Biomed Res Int. 2015;2015:865146. DOI:10.1155/2015/865146
81. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut. 2016;65(5):870-8. DOI:10.1136/gutjnl-2015-311019
82. Барышникова Н.В., Ткаченко Е.И., Успенский Ю.П. Оптимизация лечения больных с заболеваниями, ассоциированными с инфекцией Helicobacter pylori: обоснование необходимости использования препаратов висмута. Экспериментальная и клиническая гастроэнтерология. 2009;6:116-21 [Baryshnikova NV, Uspenskiĭ IuP, Tkachenko EI. Optimization of treatment of patients with diseases associated with Helicobacter pylori infection: justifying of bismuth preparations using. Eksp Klin Gastroenterol. 2009;6:116-21 (in Russian)].
83. Парфенов А.И., Ручкина И.Н. Синдром раздраженного кишечника (рекомендации для практических врачей). М., 2008 [Parfenov AI, Ruchkina IN. Sindrom razdrazhennogo kishechnika (rekomendatsii dlya prakticheskikh vrachei). Moscow, 2008 (in Russian)].
84. Tulassay Z, Herszényi L. Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol. 2010;24(2):99-108. DOI:10.1016/j.bpg.2010.02.006
85. Bagchi D, McGinn TR, Ye X, et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci. 1999;44(12):2419-28. DOI:10.1023/a:1026618501729
86. Кононов А.В., Мозговой С.И., Рыбкина Л.Б., и др. Оценка цитопротективного влияния висмута трикалия дицитрата на слизистую оболочку желудка при эрадикации H. pylori и пролонгированном приеме препарата. Российский журнал гастроэнтерологии, гепатологии и колопроктологии. 2014;24(5):21-8 [Kononov AV, Mozgovoi SI, Rybkina LB, et al. Otsenka tsitoprotektivnogo vliianiia vismuta trikaliia ditsitrata na slizistuiu obolochku zheludka pri eradikatsii H. pylori i prolongirovannom prieme preparata. Rossiiskii zhurnal gastroenterologii, gepatologii i koloproktologii. 2014;24(5):21-8 (in Russian)].
87. Петленко И.С., Егорова Т.Ю., Петленко С.В., и др. Экспериментальное изучение специфической активности L-Глутамил-L-Триптофана. Современные проблемы науки и образования. 2019;3:175 [Petlenko IS, Egorova TY, Petlenko SV, et al. Experimental study of the specific activity of L-glutamyl- L-tryptophan. Sovremennye problemy nauki i obrazovaniya. 2019;3:175 (in Russian)].
88. Петленко С.В. Иммунная система человека в условиях химической опасности. Автореф. дис. ... д-ра мед. наук. СПб, 2007 [Petlenko SV. Immunnaya sistema cheloveka v usloviyakh khimicheskoi opasnosti. Avtoref. dis. ... d-ra med. nauk. Saint Petersburg, 2007 (in Russian)].
89. Петленко С.В., Иванов М.Б., Лось С.П., и др. Новый подход к интегральной оценке иммунной системы человека в условиях воздействия комплекса факторов химически опасных объектов. Medline.ru. Российский биомедицинский журнал. 2010;11:195-216 [Petlenko SV, Ivanov MB, Los SP, et al. The new approach to an integrates estimation of immune system of the person in conditions of influence of a complex of factors of objects of chemical hazard. Medline.ru. Rossiiskii biomeditsinskii zhurnal. 2010;11:195-216 (in Russian)].
90. Успенский Ю.П., Барышникова Н.В., Краснов А.А., и др. Влияние Регастим Гастро на восстановление кислотопродукции в желудке по данным суточной рН-метрии у больных хроническим атрофическим гастритом. Экспериментальная и клиническая гастроэнтерология. 2022;198(2):40-7 [Uspenskiy YuP, Baryshnikova NV, Krasnov AA, et al. The effectiveness of Regasthym Gastro in restoring acid production in the stomach according to daily pH-metry in patients with chronic atrophic gastritis. Experimental and Clinical Gastroenterology. 2022;198(2):40-7 (in Russian)]. DOI:10.31146/1682-8658-ecg-198-2-40-47
2. Roser M, Ritchie H. Cancer. Available at: https://ourworldindata.org/cancer. Accessed: 09.09.2022.
3. Herrera V, Parsonnet J. Helicobacter pylori and gastric adenocarcinoma. Clin Microbiol Infect. 2009;15(11):971-6. DOI:10.1111/j.1469-0691.2009.03031.x
4. Bordin DS. Rak zheludka: na chto obratit' vnimanie vrachu pervichnogo zvena? Lechashchii vrach. 2022. Available at: https://www.lvrach.ru/articles/15438338?ysclid=l8blqxl25u93728977. Accessed: 09.09.2022 (in Russian).
5. World Cancer Report. Available at: https://www.iarc.who.int/featured-news/new-world-cancer-report/ Accessed: 09.09.2022.
6. Zaridze DG. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 26-30, 34-56 (in Russian).
7. Kopnin BP. Opukholevye supressory i mutatornye geny. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 86-87 (in Russian).
8. Chernousov AF, Polikarpov SA, Godzhelo EA. Rannii rak i predopukholevye zabolevaniia zheludka. Moscow: IzdAT, 2002 (in Russian).
9. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3(4):219-25. DOI:10.1007/pl00011720
10. Sel'chuk VIu, Nikulin MP. Rak zheludka. RMZh. 2003;26:1441 (in Russian).
11. Prokhorov AV, Labunets IN, Korotkevich PE, Gedrevich ZE. Rak zheludka: uchebno-metodicheskoe posobie. Minsk: BGMU, 2021 (in Russian).
12. Peng WJ, Jia XJ, Wei BG, et al. Stomach cancer mortality among workers exposed to asbestos: a meta-analysis. J Cancer Res Clin Oncol. 2015;141(7):1141-9.
DOI:10.1007/s00432-014-1791-3
13. Welling R, Beaumont JJ, Petersen SJ, et al. Chromium VI and stomach cancer: a metaanalysis of the current epidemiological evidence. Occup Environ Med. 2015;72(2):151-9. DOI:10.1136/oemed-2014-102178
14. Yaghoobi M, Bijarchi R, Narod SA. Family history and the risk of gastric cancer. Br J Cancer. 2010;102(2):237-42. DOI:10.1038/sj.bjc.6605380
15. van der Post RS, Vogelaar IP, Carneiro F, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 2015;52(6):361-74. DOI:10.1136/jmedgenet-2015-103094
16. Lunet N, Valbuena C, Vieira AL, et al. Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 2007;16(4):312-27. DOI:10.1097/01.cej.0000236255.95769.22
17. Huang Y, Chen H, Zhou L, et al. Association between green tea intake and risk of gastric cancer: a systematic review and dose-response meta-analysis of observational studies. Public Health Nutr. 2017;20(17):3183-92. DOI:10.1017/S1368980017002208
18. Kim SR, Kim K, Lee SA, et al. Effect of Red, Processed, and White Meat Consumption on the Risk of Gastric Cancer: An Overall and Dose-Response Meta-Analysis. Nutrients. 2019;11(4):826. DOI:10.3390/nu11040826
19. Buckland G, Travier N, Huerta JM, et al. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study. Int J Cancer. 2015;137(3):598-606. DOI:10.1002/ijc.29411
20. Fang X, Wei J, He X, et al. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer. 2015;51(18):2820-32. DOI:10.1016/j.ejca.2015.09.010
21. Ferro A, Rosato V, Rota M, et al. Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project. Int J Cancer. 2020;147(1):45-55. DOI:10.1002/ijc.32707
22. González CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(5):345-54. DOI:10.1093/jnci/djj071
23. Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open. 2017;7(10):e017739. DOI:10.1136/bmjopen-2017-017739
24. Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut. 2018;67(1):28-35. DOI:10.1136/gutjnl-2017-314605
25. Suissa S, Suissa A. Proton-pump inhibitors and increased gastric cancer risk: time-related biases. Gut. 2018;67(12):2228-9. DOI:10.1136/gutjnl-2017-315729
26. Waldum HL, Sandvik AK, Brenna E, Petersen H. Gastrin-histamine sequence in the regulation of gastric acid secretion. Gut. 1991;32(6):698-701. DOI:10.1136/gut.32.6.698
27. Berlin RG. Omeprazole. Gastrin and gastric endocrine cell data from clinical studies. Dig Dis Sci. 1991;36(2):129-36. DOI:10.1007/BF01300745
28. Kidd M, Tang LH, Modlin IM, et al. Gastrin-mediated alterations in gastric epithelial apoptosis and proliferation in a mastomys rodent model of gastric neoplasia. Digestion. 2000;62(2-3):143-51. DOI:10.1159/000007806
29. Ho AC, Horton KM, Fishman EK. Gastric carcinoid tumors as a consequence of chronic hypergastrinemia: spiral CT findings. Clin Imaging. 2000;24(4):200-3.
DOI:10.1016/s0899-7071(00)00199-6
30. Henwood M, Clarke PA, Smith AM, Watson SA. Expression of gastrin in developing gastric adenocarcinoma. Br J Surg. 2001;88(4):564-8. DOI:10.1046/j.1365-2168.2001.01716.x
31. Dockray GJ, Varro A, Dimaline R, Wang T. The gastrins: their production and biological activities. Annu Rev Physiol. 2001;63:119-39. DOI:10.1146/annurev.physiol.63.1.119
32. Risk razvitiia zlokachestvennykh novoobrazovanii u bol'nykh, poluchaiushchikh ingibitory protonnoi pompy. Available at: https://rosoncoweb.ru/news/oncology/2016/01/27/ Accessed: 09.09.2022 (in Russian).
33. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334(16):1018-22. DOI:10.1056/NEJM199604183341603
34. Moayyedi P, Wason C, Peacock R, et al. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter. 2000;5(4):206-14.
DOI:10.1046/j.1523-5378.2000.00032.x
35. Lundell L, Havu N, Miettinen P, et al. Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial. Aliment Pharmacol Ther. 2006;23(5):639-47. DOI:10.1111/j.1365-2036.2006.02792.x
36. González CA, Pera G, Agudo A, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003;107(4):629-34. DOI:10.1002/ijc.11426
37. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 83: Tobacco Smoke and Involuntary Smoking. Lyon: International Agency for Research on Cancer, 2004. Available at: https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono83-1.pdf. Accessed: 09.09.2022.
38. Rota M, Pelucchi C, Bertuccio P, et al. Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium. Int J Cancer. 2017;141(10):1950-62. DOI:10.1002/ijc.30891
39. Ma K, Baloch Z, He TT, Xia X. Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis. Med Sci Monit. 2017;23:238-46. DOI:10.12659/msm.899423
40. Tavakoli A, Monavari SH, Solaymani Mohammadi F, et al. Association between Epstein–Barr virus infection and gastric cancer: a systematic review and meta-analysis. BMC Cancer. 2020;20(1):493. DOI:10.1186/s12885-020-07013-x
41. Cárdenas-Mondragón MG, Torres J, Flores-Luna L, et al. Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease. Br J Cancer. 2015;112(12):1866-73. DOI:10.1038/bjc.2015.175
42. Dávila-Collado R, Jarquín-Durán O, Dong LT, Espinoza JL. Epstein–Barr Virus and Helicobacter Pylori Co-Infection in Non-Malignant Gastroduodenal Disorders. Pathogens. 2020;9(2):104. DOI:10.3390/pathogens9020104
43. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
44. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol. 1995;19(Suppl. 1):S37-43.
45. Correa P. Gastric cancer: overview. Gastroenterol Clin North Am. 2013;42(2):211-7. DOI:10.1016/j.gtc.2013.01.002
46. de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607-15. DOI:10.1016/S1470-2045(12)70137-7
47. Ekström AM, Held M, Hansson LE, et al. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology. 2001;121(4):784-91. DOI:10.1053/gast.2001.27999
48. Mitchell H, English DR, Elliott F, et al. Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer. Aliment Pharmacol Ther. 2008;28(7):903-10. DOI:10.1111/j.1365-2036.2008.03792.x
49. Brenner H, Arndt V, Stegmaier C, et al. Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer? Am J Epidemiol. 2004;159(3):252-8. DOI:10.1093/aje/kwh039
50. Shakeri R, Malekzadeh R, Nasrollahzadeh D, et al. Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas. Cancer Res. 2015;75(22):4876-83. DOI:10.1158/0008-5472.CAN-15-0556
51. Simán JH, Engstrand L, Berglund G, et al. Helicobacter pylori and CagA seropositivity and its association with gastric and oesophageal carcinoma. Scand J Gastroenterol. 2007;42(8):933-40. DOI:10.1080/00365520601173863
52. Kong YJ, Yi HG, Dai JC, Wei MX. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis. World J Gastroenterol. 2014;20(19):5903-11. DOI:10.3748/wjg.v20.i19.5903
53. Chen HN, Wang Z, Li X, Zhou ZG. Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis. Gastric Cancer. 2016;19(1):166-75. DOI:10.1007/s10120-015-0462-7
54. Ivashkin VT, Mayev IV, Lapina TL, et al. Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(1):55-70 (in Russian). DOI:10.22416/1382-4376-2018-28-1-55-70
55. Lazebnik LB, Tkachenko EI, Abdulganiyeva DI, et al. VI National guidelines for the diagnosis and treatment of acid-related and Helicobacter Pylori-Associated diseases (VI Moscow agreement). Experimental and Clinical Gastroenterology. 2017;2:3-21 (in Russian).
56. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64(9):1353-67. DOI:10.1136/gutjnl-2015-309252
57. Kodama M, Murakami K, Okimoto T, et al. Helicobacter pylori eradication improves gastric atrophy and intestinal metaplasia in long-term observation. Digestion. 2012;85(2):126-30. DOI:10.1159/000334684
58. Poorolajal J, Moradi L, Mohammadi Y, et al. Risk factors for stomach cancer: a systematic review and meta-analysis. Epidemiol Health. 2020;42:e2020004. DOI:10.4178/epih.e2020004
59. Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012;17(7):2383-90. DOI:10.2741/4059
60. Harvey AE, Lashinger LM, Hursting SD. The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci. 2011;1229:45-52.
DOI:10.1111/j.1749-6632.2011.06096.x
61. Mohammadi M. Role of Obesity in the Tumorigenesis of Gastric Cancer. Int J Prev Med. 2020;11:148. DOI:10.4103/ijpvm.IJPVM_153_19
62. Hursting SD, Berger NA. Energy balance, host-related factors, and cancer progression. J Clin Oncol. 2010;28(26):4058-65. DOI:10.1200/JCO.2010.27.9935
63. Stewart OA, Wu F, Chen Y. The role of gastric microbiota in gastric cancer. Gut Microbes. 2020;11(5):1220-30. DOI:10.1080/19490976.2020.1762520
64. Dai D, Yang Y, Yu J, et al. Interactions between gastric microbiota and metabolites in gastric cancer. Cell Death Dis. 2021;12(12):1104. DOI:10.1038/s41419-021-04396-y
65. Bessède E, Mégraud F. Microbiota and gastric cancer. Semin Cancer Biol. 2022;86(Pt. 3):11-7. DOI:10.1016/j.semcancer.2022.05.001
66. Aviles-Jimenez F, Vazquez-Jimenez F, Medrano-Guzman R, et al. Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer. Sci Rep. 2014;4:4202. DOI:10.1038/srep04202
67. Eun CS, Kim BK, Han DS, et al. Differences in gastric mucosal microbiota profiling in patients with chronic gastritis, intestinal metaplasia, and gastric cancer using pyrosequencing methods. Helicobacter. 2014;19(6):407-16. DOI:10.1111/hel.12145
68. Castaño-Rodríguez N, Goh KL, Fock KM, et al. Dysbiosis of the microbiome in gastric carcinogenesis. Sci Rep. 2017;7(1):15957. DOI:10.1038/s41598-017-16289-2
69. Sonveaux P, Copetti T, De Saedeleer CJ, et al. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PLoS One. 2012;7(3):e33418. DOI:10.1371/journal.pone.0033418
70. Berry D, Reinisch W. Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases? Best Pract Res Clin Gastroenterol. 2013;27(1):47-58. DOI:10.1016/j.bpg.2013.03.005
71. Wang L, Zhou J, Xin Y, et al. Bacterial overgrowth and diversification of microbiota in gastric cancer. Eur J Gastroenterol Hepatol. 2016;28(3):261-6. DOI:10.1097/MEG.0000000000000542
72. Bakulin IG, Pirogov SS, Bakulina NV, et al. Prophylaxis and early diagnosis of stomach cancer. Dokazatel'naya gastroenterologiya. 2018;7(2):44-58 (in Russian). DOI:10.17116/dokgastro201872244
73. Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol. 2015;29(6):895-905. DOI:10.1016/j.bpg.2015.09.013
74. Lee S, Jun JK, Suh M, et al. Gastric cancer screening uptake trends in Korea: results for the National Cancer Screening Program from 2002 to 2011: a prospective cross-sectional study. Medicine (Baltimore). 2015;94(8):e533. DOI:10.1097/MD.0000000000000533
75. Kim GH, Liang PS, Bang SJ, Hwang JH. Screening and surveillance for gastric cancer in the United States: Is it needed? Gastrointest Endosc. 2016;84(1):18-28. DOI:10.1016/j.gie.2016.02.028
76. Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. DOI:10.1586/egh.10.25
77. Haruma K, Ito M. Review article: clinical significance of mucosal- protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther. 2003;18(Suppl. 1):153-9. DOI:10.1046/j.1365-2036.18. s1.17.x
78. Hayashi S, Sugiyama T, Amano K, et al. Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells. Antimicrob Agents Chemother. 1998;42(8):1895-9. DOI:10.1128/AAC.42.8.1895
79. Haruma K, Ito M, Kido S, et al. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis. Dig Dis Sci. 2002;47(4):862-7. DOI:10.1023/a:1014716822702
80. Kamada T, Sato M, Tokutomi T, et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study. Biomed Res Int. 2015;2015:865146. DOI:10.1155/2015/865146
81. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut. 2016;65(5):870-8. DOI:10.1136/gutjnl-2015-311019
82. Baryshnikova NV, Uspenskiĭ IuP, Tkachenko EI. Optimization of treatment of patients with diseases associated with Helicobacter pylori infection: justifying of bismuth preparations using. Eksp Klin Gastroenterol. 2009;6:116-21 (in Russian).
83. Parfenov AI, Ruchkina IN. Sindrom razdrazhennogo kishechnika (rekomendatsii dlya prakticheskikh vrachei). Moscow, 2008 (in Russian).
84. Tulassay Z, Herszényi L. Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol. 2010;24(2):99-108. DOI:10.1016/j.bpg.2010.02.006
85. Bagchi D, McGinn TR, Ye X, et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci. 1999;44(12):2419-28. DOI:10.1023/a:1026618501729
86. Kononov AV, Mozgovoi SI, Rybkina LB, et al. Otsenka tsitoprotektivnogo vliianiia vismuta trikaliia ditsitrata na slizistuiu obolochku zheludka pri eradikatsii H. pylori i prolongirovannom prieme preparata. Rossiiskii zhurnal gastroenterologii, gepatologii i koloproktologii. 2014;24(5):21-8 (in Russian).
87. Petlenko IS, Egorova TY, Petlenko SV, et al. Experimental study of the specific activity of L-glutamyl- L-tryptophan. Sovremennye problemy nauki i obrazovaniya. 2019;3:175 (in Russian).
88. Petlenko SV. Immunnaya sistema cheloveka v usloviyakh khimicheskoi opasnosti. Avtoref. dis. ... d-ra med. nauk. Saint Petersburg, 2007 (in Russian).
89. Petlenko SV, Ivanov MB, Los SP, et al. The new approach to an integrates estimation of immune system of the person in conditions of influence of a complex of factors of objects of chemical hazard. Medline.ru. Rossiiskii biomeditsinskii zhurnal. 2010;11:195-216 (in Russian).
90. Uspenskiy YuP, Baryshnikova NV, Krasnov AA, et al. The effectiveness of Regasthym Gastro in restoring acid production in the stomach according to daily pH-metry in patients with chronic atrophic gastritis. Experimental and Clinical Gastroenterology. 2022;198(2):40-7 (in Russian). DOI:10.31146/1682-8658-ecg-198-2-40-47
2. Roser M, Ritchie H. Cancer. Available at: https://ourworldindata.org/cancer. Accessed: 09.09.2022.
3. Herrera V, Parsonnet J. Helicobacter pylori and gastric adenocarcinoma. Clin Microbiol Infect. 2009;15(11):971-6. DOI:10.1111/j.1469-0691.2009.03031.x
4. Бордин Д.С. Рак желудка: на что обратить внимание врачу первичного звена? Лечащий врач. 2022. Режим доступа: https://www.lvrach.ru/articles/15438338?ysclid=l8blqxl25u937289776. Ссылка активна на 09.09.2022 [Bordin DS. Rak zheludka: na chto obratit' vnimanie vrachu pervichnogo zvena? Lechashchii vrach. 2022. Available at: https://www.lvrach.ru/articles/15438338?ysclid=l8blqxl25u93728977. Accessed: 09.09.2022 (in Russian)].
5. World Cancer Report. Available at: https://www.iarc.who.int/featured-news/new-world-cancer-report/ Accessed: 09.09.2022.
6. Заридзе Д.Г. Эпидемиология и этиология злокачественных заболеваний. Канцерогенез. М.: Научный мир, 2000, с. 26-30, 34-56 [Zaridze DG. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 26-30, 34-56 (in Russian)].
7. Копнин Б.П. Опухолевые супрессоры и мутаторные гены. Канцерогенез. М.: Научный мир, 2000, с. 86-87 [Kopnin BP. Opukholevye supressory i mutatornye geny. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 86-87 (in Russian)].
8. Черноусов А.Ф., Поликарпов С.А., Годжело Э.А. Ранний рак и предопухолевые заболевания желудка. М.: ИздАТ, 2002 [Chernousov AF, Polikarpov SA, Godzhelo EA. Rannii rak i predopukholevye zabolevaniia zheludka. Moscow: IzdAT, 2002 (in Russian)].
9. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3(4):219-25. DOI:10.1007/pl00011720
10. Сельчук В.Ю., Никулин М.П. Рак желудка. РМЖ. 2003;26:1441 [Sel'chuk VIu, Nikulin MP. Rak zheludka. RMZh. 2003;26:1441 (in Russian)].
11. Прохоров А.В., Лабунец И.Н., Короткевич П.Е., Гедревич З.Э. Рак желудка: учебно-методическое пособие. Минск: БГМУ, 2021 [Prokhorov AV, Labunets IN, Korotkevich PE, Gedrevich ZE. Rak zheludka: uchebno-metodicheskoe posobie. Minsk: BGMU, 2021 (in Russian)].
12. Peng WJ, Jia XJ, Wei BG, et al. Stomach cancer mortality among workers exposed to asbestos: a meta-analysis. J Cancer Res Clin Oncol. 2015;141(7):1141-9.
DOI:10.1007/s00432-014-1791-3
13. Welling R, Beaumont JJ, Petersen SJ, et al. Chromium VI and stomach cancer: a metaanalysis of the current epidemiological evidence. Occup Environ Med. 2015;72(2):151-9. DOI:10.1136/oemed-2014-102178
14. Yaghoobi M, Bijarchi R, Narod SA. Family history and the risk of gastric cancer. Br J Cancer. 2010;102(2):237-42. DOI:10.1038/sj.bjc.6605380
15. van der Post RS, Vogelaar IP, Carneiro F, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 2015;52(6):361-74. DOI:10.1136/jmedgenet-2015-103094
16. Lunet N, Valbuena C, Vieira AL, et al. Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 2007;16(4):312-27. DOI:10.1097/01.cej.0000236255.95769.22
17. Huang Y, Chen H, Zhou L, et al. Association between green tea intake and risk of gastric cancer: a systematic review and dose-response meta-analysis of observational studies. Public Health Nutr. 2017;20(17):3183-92. DOI:10.1017/S1368980017002208
18. Kim SR, Kim K, Lee SA, et al. Effect of Red, Processed, and White Meat Consumption on the Risk of Gastric Cancer: An Overall and Dose-Response Meta-Analysis. Nutrients. 2019;11(4):826. DOI:10.3390/nu11040826
19. Buckland G, Travier N, Huerta JM, et al. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study. Int J Cancer. 2015;137(3):598-606. DOI:10.1002/ijc.29411
20. Fang X, Wei J, He X, et al. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer. 2015;51(18):2820-32. DOI:10.1016/j.ejca.2015.09.010
21. Ferro A, Rosato V, Rota M, et al. Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project. Int J Cancer. 2020;147(1):45-55. DOI:10.1002/ijc.32707
22. González CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(5):345-54. DOI:10.1093/jnci/djj071
23. Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open. 2017;7(10):e017739. DOI:10.1136/bmjopen-2017-017739
24. Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut. 2018;67(1):28-35. DOI:10.1136/gutjnl-2017-314605
25. Suissa S, Suissa A. Proton-pump inhibitors and increased gastric cancer risk: time-related biases. Gut. 2018;67(12):2228-9. DOI:10.1136/gutjnl-2017-315729
26. Waldum HL, Sandvik AK, Brenna E, Petersen H. Gastrin-histamine sequence in the regulation of gastric acid secretion. Gut. 1991;32(6):698-701. DOI:10.1136/gut.32.6.698
27. Berlin RG. Omeprazole. Gastrin and gastric endocrine cell data from clinical studies. Dig Dis Sci. 1991;36(2):129-36. DOI:10.1007/BF01300745
28. Kidd M, Tang LH, Modlin IM, et al. Gastrin-mediated alterations in gastric epithelial apoptosis and proliferation in a mastomys rodent model of gastric neoplasia. Digestion. 2000;62(2-3):143-51. DOI:10.1159/000007806
29. Ho AC, Horton KM, Fishman EK. Gastric carcinoid tumors as a consequence of chronic hypergastrinemia: spiral CT findings. Clin Imaging. 2000;24(4):200-3.
DOI:10.1016/s0899-7071(00)00199-6
30. Henwood M, Clarke PA, Smith AM, Watson SA. Expression of gastrin in developing gastric adenocarcinoma. Br J Surg. 2001;88(4):564-8. DOI:10.1046/j.1365-2168.2001.01716.x
31. Dockray GJ, Varro A, Dimaline R, Wang T. The gastrins: their production and biological activities. Annu Rev Physiol. 2001;63:119-39. DOI:10.1146/annurev.physiol.63.1.119
32. Риск развития злокачественных новообразований у больных, получающих ингибиторы протонной помпы. Режим доступа: https://rosoncoweb.ru/news/oncology/2016/01/27/ Ссылка активна на 09.09.2022 [Risk razvitiia zlokachestvennykh novoobrazovanii u bol'nykh, poluchaiushchikh ingibitory protonnoi pompy. Available at: https://rosoncoweb.ru/news/oncology/2016/01/27/ Accessed: 09.09.2022 (in Russian)].
33. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334(16):1018-22. DOI:10.1056/NEJM199604183341603
34. Moayyedi P, Wason C, Peacock R, et al. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter. 2000;5(4):206-14.
DOI:10.1046/j.1523-5378.2000.00032.x
35. Lundell L, Havu N, Miettinen P, et al. Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial. Aliment Pharmacol Ther. 2006;23(5):639-47. DOI:10.1111/j.1365-2036.2006.02792.x
36. González CA, Pera G, Agudo A, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003;107(4):629-34. DOI:10.1002/ijc.11426
37. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 83: Tobacco Smoke and Involuntary Smoking. Lyon: International Agency for Research on Cancer, 2004. Available at: https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono83-1.pdf. Accessed: 09.09.2022.
38. Rota M, Pelucchi C, Bertuccio P, et al. Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium. Int J Cancer. 2017;141(10):1950-62. DOI:10.1002/ijc.30891
39. Ma K, Baloch Z, He TT, Xia X. Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis. Med Sci Monit. 2017;23:238-46. DOI:10.12659/msm.899423
40. Tavakoli A, Monavari SH, Solaymani Mohammadi F, et al. Association between Epstein–Barr virus infection and gastric cancer: a systematic review and meta-analysis. BMC Cancer. 2020;20(1):493. DOI:10.1186/s12885-020-07013-x
41. Cárdenas-Mondragón MG, Torres J, Flores-Luna L, et al. Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease. Br J Cancer. 2015;112(12):1866-73. DOI:10.1038/bjc.2015.175
42. Dávila-Collado R, Jarquín-Durán O, Dong LT, Espinoza JL. Epstein–Barr Virus and Helicobacter Pylori Co-Infection in Non-Malignant Gastroduodenal Disorders. Pathogens. 2020;9(2):104. DOI:10.3390/pathogens9020104
43. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
44. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol. 1995;19(Suppl. 1):S37-43.
45. Correa P. Gastric cancer: overview. Gastroenterol Clin North Am. 2013;42(2):211-7. DOI:10.1016/j.gtc.2013.01.002
46. de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607-15. DOI:10.1016/S1470-2045(12)70137-7
47. Ekström AM, Held M, Hansson LE, et al. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology. 2001;121(4):784-91. DOI:10.1053/gast.2001.27999
48. Mitchell H, English DR, Elliott F, et al. Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer. Aliment Pharmacol Ther. 2008;28(7):903-10. DOI:10.1111/j.1365-2036.2008.03792.x
49. Brenner H, Arndt V, Stegmaier C, et al. Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer? Am J Epidemiol. 2004;159(3):252-8. DOI:10.1093/aje/kwh039
50. Shakeri R, Malekzadeh R, Nasrollahzadeh D, et al. Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas. Cancer Res. 2015;75(22):4876-83. DOI:10.1158/0008-5472.CAN-15-0556
51. Simán JH, Engstrand L, Berglund G, et al. Helicobacter pylori and CagA seropositivity and its association with gastric and oesophageal carcinoma. Scand J Gastroenterol. 2007;42(8):933-40. DOI:10.1080/00365520601173863
52. Kong YJ, Yi HG, Dai JC, Wei MX. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis. World J Gastroenterol. 2014;20(19):5903-11. DOI:10.3748/wjg.v20.i19.5903
53. Chen HN, Wang Z, Li X, Zhou ZG. Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis. Gastric Cancer. 2016;19(1):166-75. DOI:10.1007/s10120-015-0462-7
54. Ивашкин В.Т., Маев И.В., Лапина Т.Л., и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2018;28(1):55-70 [Ivashkin VT, Mayev IV, Lapina TL, et al. Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(1):55-70 (in Russian)]. DOI:10.22416/1382-4376-2018-28-1-55-70
55. Лазебник Л.Б., Ткаченко Е.И., Абдулганиева Д.И., и др. VI Национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helicobacter pylori заболеваний (VI Московские соглашения). Экспериментальная и клиническая гастроэнтерология. 2017;2:3-21 [Lazebnik LB, Tkachenko EI, Abdulganiyeva DI, et al. VI National guidelines for the diagnosis and treatment of acid-related and Helicobacter Pylori-Associated diseases (VI Moscow agreement). Experimental and Clinical Gastroenterology. 2017;2:3-21 (in Russian)].
56. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64(9):1353-67. DOI:10.1136/gutjnl-2015-309252
57. Kodama M, Murakami K, Okimoto T, et al. Helicobacter pylori eradication improves gastric atrophy and intestinal metaplasia in long-term observation. Digestion. 2012;85(2):126-30. DOI:10.1159/000334684
58. Poorolajal J, Moradi L, Mohammadi Y, et al. Risk factors for stomach cancer: a systematic review and meta-analysis. Epidemiol Health. 2020;42:e2020004. DOI:10.4178/epih.e2020004
59. Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012;17(7):2383-90. DOI:10.2741/4059
60. Harvey AE, Lashinger LM, Hursting SD. The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci. 2011;1229:45-52.
DOI:10.1111/j.1749-6632.2011.06096.x
61. Mohammadi M. Role of Obesity in the Tumorigenesis of Gastric Cancer. Int J Prev Med. 2020;11:148. DOI:10.4103/ijpvm.IJPVM_153_19
62. Hursting SD, Berger NA. Energy balance, host-related factors, and cancer progression. J Clin Oncol. 2010;28(26):4058-65. DOI:10.1200/JCO.2010.27.9935
63. Stewart OA, Wu F, Chen Y. The role of gastric microbiota in gastric cancer. Gut Microbes. 2020;11(5):1220-30. DOI:10.1080/19490976.2020.1762520
64. Dai D, Yang Y, Yu J, et al. Interactions between gastric microbiota and metabolites in gastric cancer. Cell Death Dis. 2021;12(12):1104. DOI:10.1038/s41419-021-04396-y
65. Bessède E, Mégraud F. Microbiota and gastric cancer. Semin Cancer Biol. 2022;86(Pt. 3):11-7. DOI:10.1016/j.semcancer.2022.05.001
66. Aviles-Jimenez F, Vazquez-Jimenez F, Medrano-Guzman R, et al. Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer. Sci Rep. 2014;4:4202. DOI:10.1038/srep04202
67. Eun CS, Kim BK, Han DS, et al. Differences in gastric mucosal microbiota profiling in patients with chronic gastritis, intestinal metaplasia, and gastric cancer using pyrosequencing methods. Helicobacter. 2014;19(6):407-16. DOI:10.1111/hel.12145
68. Castaño-Rodríguez N, Goh KL, Fock KM, et al. Dysbiosis of the microbiome in gastric carcinogenesis. Sci Rep. 2017;7(1):15957. DOI:10.1038/s41598-017-16289-2
69. Sonveaux P, Copetti T, De Saedeleer CJ, et al. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PLoS One. 2012;7(3):e33418. DOI:10.1371/journal.pone.0033418
70. Berry D, Reinisch W. Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases? Best Pract Res Clin Gastroenterol. 2013;27(1):47-58. DOI:10.1016/j.bpg.2013.03.005
71. Wang L, Zhou J, Xin Y, et al. Bacterial overgrowth and diversification of microbiota in gastric cancer. Eur J Gastroenterol Hepatol. 2016;28(3):261-6. DOI:10.1097/MEG.0000000000000542
72. Бакулин И.Г., Пирогов С.С., Бакулина Н.В., и др. Профилактика и ранняя диагностика рака желудка. Доказательная гастроэнтерология. 2018;7(2):44-58 [Bakulin IG, Pirogov SS, Bakulina NV, et al. Prophylaxis and early diagnosis of stomach cancer. Dokazatel'naya gastroenterologiya. 2018;7(2):44-58 (in Russian)]. DOI:10.17116/dokgastro201872244
73. Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol. 2015;29(6):895-905. DOI:10.1016/j.bpg.2015.09.013
74. Lee S, Jun JK, Suh M, et al. Gastric cancer screening uptake trends in Korea: results for the National Cancer Screening Program from 2002 to 2011: a prospective cross-sectional study. Medicine (Baltimore). 2015;94(8):e533. DOI:10.1097/MD.0000000000000533
75. Kim GH, Liang PS, Bang SJ, Hwang JH. Screening and surveillance for gastric cancer in the United States: Is it needed? Gastrointest Endosc. 2016;84(1):18-28. DOI:10.1016/j.gie.2016.02.028
76. Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. DOI:10.1586/egh.10.25
77. Haruma K, Ito M. Review article: clinical significance of mucosal- protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther. 2003;18(Suppl. 1):153-9. DOI:10.1046/j.1365-2036.18. s1.17.x
78. Hayashi S, Sugiyama T, Amano K, et al. Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells. Antimicrob Agents Chemother. 1998;42(8):1895-9. DOI:10.1128/AAC.42.8.1895
79. Haruma K, Ito M, Kido S, et al. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis. Dig Dis Sci. 2002;47(4):862-7. DOI:10.1023/a:1014716822702
80. Kamada T, Sato M, Tokutomi T, et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study. Biomed Res Int. 2015;2015:865146. DOI:10.1155/2015/865146
81. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut. 2016;65(5):870-8. DOI:10.1136/gutjnl-2015-311019
82. Барышникова Н.В., Ткаченко Е.И., Успенский Ю.П. Оптимизация лечения больных с заболеваниями, ассоциированными с инфекцией Helicobacter pylori: обоснование необходимости использования препаратов висмута. Экспериментальная и клиническая гастроэнтерология. 2009;6:116-21 [Baryshnikova NV, Uspenskiĭ IuP, Tkachenko EI. Optimization of treatment of patients with diseases associated with Helicobacter pylori infection: justifying of bismuth preparations using. Eksp Klin Gastroenterol. 2009;6:116-21 (in Russian)].
83. Парфенов А.И., Ручкина И.Н. Синдром раздраженного кишечника (рекомендации для практических врачей). М., 2008 [Parfenov AI, Ruchkina IN. Sindrom razdrazhennogo kishechnika (rekomendatsii dlya prakticheskikh vrachei). Moscow, 2008 (in Russian)].
84. Tulassay Z, Herszényi L. Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol. 2010;24(2):99-108. DOI:10.1016/j.bpg.2010.02.006
85. Bagchi D, McGinn TR, Ye X, et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci. 1999;44(12):2419-28. DOI:10.1023/a:1026618501729
86. Кононов А.В., Мозговой С.И., Рыбкина Л.Б., и др. Оценка цитопротективного влияния висмута трикалия дицитрата на слизистую оболочку желудка при эрадикации H. pylori и пролонгированном приеме препарата. Российский журнал гастроэнтерологии, гепатологии и колопроктологии. 2014;24(5):21-8 [Kononov AV, Mozgovoi SI, Rybkina LB, et al. Otsenka tsitoprotektivnogo vliianiia vismuta trikaliia ditsitrata na slizistuiu obolochku zheludka pri eradikatsii H. pylori i prolongirovannom prieme preparata. Rossiiskii zhurnal gastroenterologii, gepatologii i koloproktologii. 2014;24(5):21-8 (in Russian)].
87. Петленко И.С., Егорова Т.Ю., Петленко С.В., и др. Экспериментальное изучение специфической активности L-Глутамил-L-Триптофана. Современные проблемы науки и образования. 2019;3:175 [Petlenko IS, Egorova TY, Petlenko SV, et al. Experimental study of the specific activity of L-glutamyl- L-tryptophan. Sovremennye problemy nauki i obrazovaniya. 2019;3:175 (in Russian)].
88. Петленко С.В. Иммунная система человека в условиях химической опасности. Автореф. дис. ... д-ра мед. наук. СПб, 2007 [Petlenko SV. Immunnaya sistema cheloveka v usloviyakh khimicheskoi opasnosti. Avtoref. dis. ... d-ra med. nauk. Saint Petersburg, 2007 (in Russian)].
89. Петленко С.В., Иванов М.Б., Лось С.П., и др. Новый подход к интегральной оценке иммунной системы человека в условиях воздействия комплекса факторов химически опасных объектов. Medline.ru. Российский биомедицинский журнал. 2010;11:195-216 [Petlenko SV, Ivanov MB, Los SP, et al. The new approach to an integrates estimation of immune system of the person in conditions of influence of a complex of factors of objects of chemical hazard. Medline.ru. Rossiiskii biomeditsinskii zhurnal. 2010;11:195-216 (in Russian)].
90. Успенский Ю.П., Барышникова Н.В., Краснов А.А., и др. Влияние Регастим Гастро на восстановление кислотопродукции в желудке по данным суточной рН-метрии у больных хроническим атрофическим гастритом. Экспериментальная и клиническая гастроэнтерология. 2022;198(2):40-7 [Uspenskiy YuP, Baryshnikova NV, Krasnov AA, et al. The effectiveness of Regasthym Gastro in restoring acid production in the stomach according to daily pH-metry in patients with chronic atrophic gastritis. Experimental and Clinical Gastroenterology. 2022;198(2):40-7 (in Russian)]. DOI:10.31146/1682-8658-ecg-198-2-40-47
________________________________________________
2. Roser M, Ritchie H. Cancer. Available at: https://ourworldindata.org/cancer. Accessed: 09.09.2022.
3. Herrera V, Parsonnet J. Helicobacter pylori and gastric adenocarcinoma. Clin Microbiol Infect. 2009;15(11):971-6. DOI:10.1111/j.1469-0691.2009.03031.x
4. Bordin DS. Rak zheludka: na chto obratit' vnimanie vrachu pervichnogo zvena? Lechashchii vrach. 2022. Available at: https://www.lvrach.ru/articles/15438338?ysclid=l8blqxl25u93728977. Accessed: 09.09.2022 (in Russian).
5. World Cancer Report. Available at: https://www.iarc.who.int/featured-news/new-world-cancer-report/ Accessed: 09.09.2022.
6. Zaridze DG. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 26-30, 34-56 (in Russian).
7. Kopnin BP. Opukholevye supressory i mutatornye geny. Kantserogenez. Moscow: Nauchnyi mir, 2000, p. 86-87 (in Russian).
8. Chernousov AF, Polikarpov SA, Godzhelo EA. Rannii rak i predopukholevye zabolevaniia zheludka. Moscow: IzdAT, 2002 (in Russian).
9. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3(4):219-25. DOI:10.1007/pl00011720
10. Sel'chuk VIu, Nikulin MP. Rak zheludka. RMZh. 2003;26:1441 (in Russian).
11. Prokhorov AV, Labunets IN, Korotkevich PE, Gedrevich ZE. Rak zheludka: uchebno-metodicheskoe posobie. Minsk: BGMU, 2021 (in Russian).
12. Peng WJ, Jia XJ, Wei BG, et al. Stomach cancer mortality among workers exposed to asbestos: a meta-analysis. J Cancer Res Clin Oncol. 2015;141(7):1141-9.
DOI:10.1007/s00432-014-1791-3
13. Welling R, Beaumont JJ, Petersen SJ, et al. Chromium VI and stomach cancer: a metaanalysis of the current epidemiological evidence. Occup Environ Med. 2015;72(2):151-9. DOI:10.1136/oemed-2014-102178
14. Yaghoobi M, Bijarchi R, Narod SA. Family history and the risk of gastric cancer. Br J Cancer. 2010;102(2):237-42. DOI:10.1038/sj.bjc.6605380
15. van der Post RS, Vogelaar IP, Carneiro F, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 2015;52(6):361-74. DOI:10.1136/jmedgenet-2015-103094
16. Lunet N, Valbuena C, Vieira AL, et al. Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 2007;16(4):312-27. DOI:10.1097/01.cej.0000236255.95769.22
17. Huang Y, Chen H, Zhou L, et al. Association between green tea intake and risk of gastric cancer: a systematic review and dose-response meta-analysis of observational studies. Public Health Nutr. 2017;20(17):3183-92. DOI:10.1017/S1368980017002208
18. Kim SR, Kim K, Lee SA, et al. Effect of Red, Processed, and White Meat Consumption on the Risk of Gastric Cancer: An Overall and Dose-Response Meta-Analysis. Nutrients. 2019;11(4):826. DOI:10.3390/nu11040826
19. Buckland G, Travier N, Huerta JM, et al. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study. Int J Cancer. 2015;137(3):598-606. DOI:10.1002/ijc.29411
20. Fang X, Wei J, He X, et al. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer. 2015;51(18):2820-32. DOI:10.1016/j.ejca.2015.09.010
21. Ferro A, Rosato V, Rota M, et al. Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project. Int J Cancer. 2020;147(1):45-55. DOI:10.1002/ijc.32707
22. González CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(5):345-54. DOI:10.1093/jnci/djj071
23. Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open. 2017;7(10):e017739. DOI:10.1136/bmjopen-2017-017739
24. Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut. 2018;67(1):28-35. DOI:10.1136/gutjnl-2017-314605
25. Suissa S, Suissa A. Proton-pump inhibitors and increased gastric cancer risk: time-related biases. Gut. 2018;67(12):2228-9. DOI:10.1136/gutjnl-2017-315729
26. Waldum HL, Sandvik AK, Brenna E, Petersen H. Gastrin-histamine sequence in the regulation of gastric acid secretion. Gut. 1991;32(6):698-701. DOI:10.1136/gut.32.6.698
27. Berlin RG. Omeprazole. Gastrin and gastric endocrine cell data from clinical studies. Dig Dis Sci. 1991;36(2):129-36. DOI:10.1007/BF01300745
28. Kidd M, Tang LH, Modlin IM, et al. Gastrin-mediated alterations in gastric epithelial apoptosis and proliferation in a mastomys rodent model of gastric neoplasia. Digestion. 2000;62(2-3):143-51. DOI:10.1159/000007806
29. Ho AC, Horton KM, Fishman EK. Gastric carcinoid tumors as a consequence of chronic hypergastrinemia: spiral CT findings. Clin Imaging. 2000;24(4):200-3.
DOI:10.1016/s0899-7071(00)00199-6
30. Henwood M, Clarke PA, Smith AM, Watson SA. Expression of gastrin in developing gastric adenocarcinoma. Br J Surg. 2001;88(4):564-8. DOI:10.1046/j.1365-2168.2001.01716.x
31. Dockray GJ, Varro A, Dimaline R, Wang T. The gastrins: their production and biological activities. Annu Rev Physiol. 2001;63:119-39. DOI:10.1146/annurev.physiol.63.1.119
32. Risk razvitiia zlokachestvennykh novoobrazovanii u bol'nykh, poluchaiushchikh ingibitory protonnoi pompy. Available at: https://rosoncoweb.ru/news/oncology/2016/01/27/ Accessed: 09.09.2022 (in Russian).
33. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334(16):1018-22. DOI:10.1056/NEJM199604183341603
34. Moayyedi P, Wason C, Peacock R, et al. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter. 2000;5(4):206-14.
DOI:10.1046/j.1523-5378.2000.00032.x
35. Lundell L, Havu N, Miettinen P, et al. Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial. Aliment Pharmacol Ther. 2006;23(5):639-47. DOI:10.1111/j.1365-2036.2006.02792.x
36. González CA, Pera G, Agudo A, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003;107(4):629-34. DOI:10.1002/ijc.11426
37. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 83: Tobacco Smoke and Involuntary Smoking. Lyon: International Agency for Research on Cancer, 2004. Available at: https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono83-1.pdf. Accessed: 09.09.2022.
38. Rota M, Pelucchi C, Bertuccio P, et al. Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium. Int J Cancer. 2017;141(10):1950-62. DOI:10.1002/ijc.30891
39. Ma K, Baloch Z, He TT, Xia X. Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis. Med Sci Monit. 2017;23:238-46. DOI:10.12659/msm.899423
40. Tavakoli A, Monavari SH, Solaymani Mohammadi F, et al. Association between Epstein–Barr virus infection and gastric cancer: a systematic review and meta-analysis. BMC Cancer. 2020;20(1):493. DOI:10.1186/s12885-020-07013-x
41. Cárdenas-Mondragón MG, Torres J, Flores-Luna L, et al. Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease. Br J Cancer. 2015;112(12):1866-73. DOI:10.1038/bjc.2015.175
42. Dávila-Collado R, Jarquín-Durán O, Dong LT, Espinoza JL. Epstein–Barr Virus and Helicobacter Pylori Co-Infection in Non-Malignant Gastroduodenal Disorders. Pathogens. 2020;9(2):104. DOI:10.3390/pathogens9020104
43. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
44. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol. 1995;19(Suppl. 1):S37-43.
45. Correa P. Gastric cancer: overview. Gastroenterol Clin North Am. 2013;42(2):211-7. DOI:10.1016/j.gtc.2013.01.002
46. de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607-15. DOI:10.1016/S1470-2045(12)70137-7
47. Ekström AM, Held M, Hansson LE, et al. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology. 2001;121(4):784-91. DOI:10.1053/gast.2001.27999
48. Mitchell H, English DR, Elliott F, et al. Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer. Aliment Pharmacol Ther. 2008;28(7):903-10. DOI:10.1111/j.1365-2036.2008.03792.x
49. Brenner H, Arndt V, Stegmaier C, et al. Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer? Am J Epidemiol. 2004;159(3):252-8. DOI:10.1093/aje/kwh039
50. Shakeri R, Malekzadeh R, Nasrollahzadeh D, et al. Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas. Cancer Res. 2015;75(22):4876-83. DOI:10.1158/0008-5472.CAN-15-0556
51. Simán JH, Engstrand L, Berglund G, et al. Helicobacter pylori and CagA seropositivity and its association with gastric and oesophageal carcinoma. Scand J Gastroenterol. 2007;42(8):933-40. DOI:10.1080/00365520601173863
52. Kong YJ, Yi HG, Dai JC, Wei MX. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis. World J Gastroenterol. 2014;20(19):5903-11. DOI:10.3748/wjg.v20.i19.5903
53. Chen HN, Wang Z, Li X, Zhou ZG. Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis. Gastric Cancer. 2016;19(1):166-75. DOI:10.1007/s10120-015-0462-7
54. Ivashkin VT, Mayev IV, Lapina TL, et al. Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(1):55-70 (in Russian). DOI:10.22416/1382-4376-2018-28-1-55-70
55. Lazebnik LB, Tkachenko EI, Abdulganiyeva DI, et al. VI National guidelines for the diagnosis and treatment of acid-related and Helicobacter Pylori-Associated diseases (VI Moscow agreement). Experimental and Clinical Gastroenterology. 2017;2:3-21 (in Russian).
56. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64(9):1353-67. DOI:10.1136/gutjnl-2015-309252
57. Kodama M, Murakami K, Okimoto T, et al. Helicobacter pylori eradication improves gastric atrophy and intestinal metaplasia in long-term observation. Digestion. 2012;85(2):126-30. DOI:10.1159/000334684
58. Poorolajal J, Moradi L, Mohammadi Y, et al. Risk factors for stomach cancer: a systematic review and meta-analysis. Epidemiol Health. 2020;42:e2020004. DOI:10.4178/epih.e2020004
59. Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012;17(7):2383-90. DOI:10.2741/4059
60. Harvey AE, Lashinger LM, Hursting SD. The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci. 2011;1229:45-52.
DOI:10.1111/j.1749-6632.2011.06096.x
61. Mohammadi M. Role of Obesity in the Tumorigenesis of Gastric Cancer. Int J Prev Med. 2020;11:148. DOI:10.4103/ijpvm.IJPVM_153_19
62. Hursting SD, Berger NA. Energy balance, host-related factors, and cancer progression. J Clin Oncol. 2010;28(26):4058-65. DOI:10.1200/JCO.2010.27.9935
63. Stewart OA, Wu F, Chen Y. The role of gastric microbiota in gastric cancer. Gut Microbes. 2020;11(5):1220-30. DOI:10.1080/19490976.2020.1762520
64. Dai D, Yang Y, Yu J, et al. Interactions between gastric microbiota and metabolites in gastric cancer. Cell Death Dis. 2021;12(12):1104. DOI:10.1038/s41419-021-04396-y
65. Bessède E, Mégraud F. Microbiota and gastric cancer. Semin Cancer Biol. 2022;86(Pt. 3):11-7. DOI:10.1016/j.semcancer.2022.05.001
66. Aviles-Jimenez F, Vazquez-Jimenez F, Medrano-Guzman R, et al. Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer. Sci Rep. 2014;4:4202. DOI:10.1038/srep04202
67. Eun CS, Kim BK, Han DS, et al. Differences in gastric mucosal microbiota profiling in patients with chronic gastritis, intestinal metaplasia, and gastric cancer using pyrosequencing methods. Helicobacter. 2014;19(6):407-16. DOI:10.1111/hel.12145
68. Castaño-Rodríguez N, Goh KL, Fock KM, et al. Dysbiosis of the microbiome in gastric carcinogenesis. Sci Rep. 2017;7(1):15957. DOI:10.1038/s41598-017-16289-2
69. Sonveaux P, Copetti T, De Saedeleer CJ, et al. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PLoS One. 2012;7(3):e33418. DOI:10.1371/journal.pone.0033418
70. Berry D, Reinisch W. Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases? Best Pract Res Clin Gastroenterol. 2013;27(1):47-58. DOI:10.1016/j.bpg.2013.03.005
71. Wang L, Zhou J, Xin Y, et al. Bacterial overgrowth and diversification of microbiota in gastric cancer. Eur J Gastroenterol Hepatol. 2016;28(3):261-6. DOI:10.1097/MEG.0000000000000542
72. Bakulin IG, Pirogov SS, Bakulina NV, et al. Prophylaxis and early diagnosis of stomach cancer. Dokazatel'naya gastroenterologiya. 2018;7(2):44-58 (in Russian). DOI:10.17116/dokgastro201872244
73. Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol. 2015;29(6):895-905. DOI:10.1016/j.bpg.2015.09.013
74. Lee S, Jun JK, Suh M, et al. Gastric cancer screening uptake trends in Korea: results for the National Cancer Screening Program from 2002 to 2011: a prospective cross-sectional study. Medicine (Baltimore). 2015;94(8):e533. DOI:10.1097/MD.0000000000000533
75. Kim GH, Liang PS, Bang SJ, Hwang JH. Screening and surveillance for gastric cancer in the United States: Is it needed? Gastrointest Endosc. 2016;84(1):18-28. DOI:10.1016/j.gie.2016.02.028
76. Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. DOI:10.1586/egh.10.25
77. Haruma K, Ito M. Review article: clinical significance of mucosal- protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther. 2003;18(Suppl. 1):153-9. DOI:10.1046/j.1365-2036.18. s1.17.x
78. Hayashi S, Sugiyama T, Amano K, et al. Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells. Antimicrob Agents Chemother. 1998;42(8):1895-9. DOI:10.1128/AAC.42.8.1895
79. Haruma K, Ito M, Kido S, et al. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis. Dig Dis Sci. 2002;47(4):862-7. DOI:10.1023/a:1014716822702
80. Kamada T, Sato M, Tokutomi T, et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study. Biomed Res Int. 2015;2015:865146. DOI:10.1155/2015/865146
81. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut. 2016;65(5):870-8. DOI:10.1136/gutjnl-2015-311019
82. Baryshnikova NV, Uspenskiĭ IuP, Tkachenko EI. Optimization of treatment of patients with diseases associated with Helicobacter pylori infection: justifying of bismuth preparations using. Eksp Klin Gastroenterol. 2009;6:116-21 (in Russian).
83. Parfenov AI, Ruchkina IN. Sindrom razdrazhennogo kishechnika (rekomendatsii dlya prakticheskikh vrachei). Moscow, 2008 (in Russian).
84. Tulassay Z, Herszényi L. Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol. 2010;24(2):99-108. DOI:10.1016/j.bpg.2010.02.006
85. Bagchi D, McGinn TR, Ye X, et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci. 1999;44(12):2419-28. DOI:10.1023/a:1026618501729
86. Kononov AV, Mozgovoi SI, Rybkina LB, et al. Otsenka tsitoprotektivnogo vliianiia vismuta trikaliia ditsitrata na slizistuiu obolochku zheludka pri eradikatsii H. pylori i prolongirovannom prieme preparata. Rossiiskii zhurnal gastroenterologii, gepatologii i koloproktologii. 2014;24(5):21-8 (in Russian).
87. Petlenko IS, Egorova TY, Petlenko SV, et al. Experimental study of the specific activity of L-glutamyl- L-tryptophan. Sovremennye problemy nauki i obrazovaniya. 2019;3:175 (in Russian).
88. Petlenko SV. Immunnaya sistema cheloveka v usloviyakh khimicheskoi opasnosti. Avtoref. dis. ... d-ra med. nauk. Saint Petersburg, 2007 (in Russian).
89. Petlenko SV, Ivanov MB, Los SP, et al. The new approach to an integrates estimation of immune system of the person in conditions of influence of a complex of factors of objects of chemical hazard. Medline.ru. Rossiiskii biomeditsinskii zhurnal. 2010;11:195-216 (in Russian).
90. Uspenskiy YuP, Baryshnikova NV, Krasnov AA, et al. The effectiveness of Regasthym Gastro in restoring acid production in the stomach according to daily pH-metry in patients with chronic atrophic gastritis. Experimental and Clinical Gastroenterology. 2022;198(2):40-7 (in Russian). DOI:10.31146/1682-8658-ecg-198-2-40-47
Авторы
Ю.П. Успенский1,2, Н.В. Барышникова*1,2,3, А.А. Краснов4, С.В. Петленко5, В.А. Апрятина6
1 ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург, Россия;
2 ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
3 ФГБНУ «Институт экспериментальной медицины», Санкт-Петербург, Россия;
4 ФГБОУ ВО «Российский государственный педагогический университет им. А.И. Герцена», Санкт-Петербург, Россия;
5 ФГБУ «Научно-клинический центр токсикологии им. акад. С.Н. Голикова» ФМБА России, Санкт-Петербург, Россия;
6 АННО ВО «Научно-исследовательский центр “Санкт-Петербургский институт биорегуляции и геронтологии”», Санкт-Петербург, Россия
*baryshnikova_nv@mail.ru
1 Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia;
2 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
3 Institute of Experimental Medicine, Saint Petersburg, Russia;
4 Herzen Russian State Pedagogical University, Saint Petersburg, Russia;
5 Golikov Research Clinical Center of Toxicology, Saint Petersburg, Russia;
6 Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia
*baryshnikova_nv@mail.ru
1 ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург, Россия;
2 ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
3 ФГБНУ «Институт экспериментальной медицины», Санкт-Петербург, Россия;
4 ФГБОУ ВО «Российский государственный педагогический университет им. А.И. Герцена», Санкт-Петербург, Россия;
5 ФГБУ «Научно-клинический центр токсикологии им. акад. С.Н. Голикова» ФМБА России, Санкт-Петербург, Россия;
6 АННО ВО «Научно-исследовательский центр “Санкт-Петербургский институт биорегуляции и геронтологии”», Санкт-Петербург, Россия
*baryshnikova_nv@mail.ru
________________________________________________
1 Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia;
2 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
3 Institute of Experimental Medicine, Saint Petersburg, Russia;
4 Herzen Russian State Pedagogical University, Saint Petersburg, Russia;
5 Golikov Research Clinical Center of Toxicology, Saint Petersburg, Russia;
6 Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia
*baryshnikova_nv@mail.ru
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