Изменения органов и тканей полости рта при новой коронавирусной инфекции (COVID-19)
Изменения органов и тканей полости рта при новой коронавирусной инфекции (COVID-19)
Трухан Д.И., Сулимов А.Ф., Трухан Л.Ю. Изменения органов и тканей полости рта при новой коронавирусной инфекции (COVID-19). Consilium Medicum. 2022;24(5):349–357.
DOI: 10.26442/20751753.2022.5.201755
Trukhan DI, Sulimov AF, Trukhan LYu. Changes in the organs and tissues of the oral cavity in the new coronavirus infection (COVID-19): A review. Consilium Medicum. 2022;24(5):348–356. DOI: 10.26442/20751753.2022.5.201755
Изменения органов и тканей полости рта при новой коронавирусной инфекции (COVID-19)
Трухан Д.И., Сулимов А.Ф., Трухан Л.Ю. Изменения органов и тканей полости рта при новой коронавирусной инфекции (COVID-19). Consilium Medicum. 2022;24(5):349–357.
DOI: 10.26442/20751753.2022.5.201755
Trukhan DI, Sulimov AF, Trukhan LYu. Changes in the organs and tissues of the oral cavity in the new coronavirus infection (COVID-19): A review. Consilium Medicum. 2022;24(5):348–356. DOI: 10.26442/20751753.2022.5.201755
Инфекция SARS-CoV-2 может вызывать изменение органов и тканей полости рта, что связано с широким распространением ангиотензин- превращающего фермента 2-го типа в ротовой полости, главным образом в эпителиальных клетках слизистой оболочки полости рта, деснах и фибробластах пародонтальной связки. Таким образом, слизистая оболочка полости рта восприимчива к инфекции SARS-CoV-2 и может являться входными воротами для вируса, а также выполнять функцию резервуара для SARS-CoV-2. Нами проведен поиск литературы за период с начала пандемии до 30 мая 2022 г., посвященной изучению изменений органов и тканей полости рта при новой коронавирусной инфекции (COVID-19), в электронных поисковых системах PubMed/MEDLINE и Scopus. Особое место в рамках изучения изменений органов и тканей полости рта при новой коронавирусной инфекции (COVID-19) занимает патология пародонта. В заключении ряда обзоров и клинических исследований отмечается важность соблюдения надлежащей гигиены полости рта и поддержания здоровья пародонта в качестве одного из важных аспектов профилактики и лечения COVID-19. В качестве перспективного направления для коррекции изменений органов и тканей полости рта при COVID-19 можно рассматривать оральные пробиотики.
SARS-CoV-2 infection can cause changes in the organs and tissues of the oral cavity, which is associated with a wide distribution of angiotensin-converting enzyme type 2 in the oral cavity, mainly epithelial cells of the oral mucosa, gums and fibroblasts of the periodontal ligament. Thus, the oral mucosa is susceptible to SARS-CoV-2 infection and may act as a gateway for the virus, as well as a reservoir for SARS-CoV-2. We searched the literature for the period from the beginning of the pandemic until May 30, 2022, devoted to the study of changes in the organs and tissues of the oral cavity with a new coronavirus infection (COVID-19) in the electronic search engines PubMed/MEDLINE and Scopus. A special place in the study of changes in the organs and tissues of the oral cavity with a new coronavirus infection (COVID-19) is occupied by periodontal pathology. A number of reviews and clinical studies conclude the importance of good oral hygiene and periodontal health as an important aspect of COVID-19 prevention and management. Oral probiotics can be considered as a promising direction for correcting changes in organs and tissues of the oral cavity in COVID-19.
1. Временные методические рекомендации Минздрава РФ «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)» (15-я версия от 22.02.2022). Режим доступа: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/392/original/%D0%92%D0%9C%D0%A0.... Ссылка активна на 26.05.2022 [Vremennye metodicheskie rekomendatsii Minzdrava RF "Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19)" (15-ia versiia ot 22.02.2022). Available: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/392/original/%D0%92%D0%9C%D0%A0.... Accessed: 26.05.2022 (in Russian)].
2. Casillas Santana MA, Arreguín Cano JA, Dib Kanán A, et al. Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis. Medicina (Kaunas). 2021;57(5):493. DOI:10.3390/medicina57050493
3. Silvestre FJ, Márquez-Arrico CF. COVID-19 and Periodontitis: A Dangerous Association? Front Pharmacol. 2022;12:789681. DOI:10.3389/fphar.2021.789681
4. Jafer MA, Hazazi MA, Mashi MH, et al. COVID-19 and Periodontitis: A Reality to Live with. J Contemp Dent Pract. 2020;21(12):1398-403.
5. Campisi G, Bizzoca ME, Lo Muzio L. COVID-19 and periodontitis: reflecting on a possible association. Head Face Med. 2021;17(1):16. DOI:10.1186/s13005-021-00267-1
6. Kusiak A, Cichońska D, Tubaja M, et al. COVID-19 manifestation in the oral cavity – a narrative literature review. Acta Otorhinolaryngol Ital. 2021;41(5):395-400.
DOI:10.14639/0392-100X-N1584
7. Basso L, Chacun D, Sy K, et al. Periodontal Diseases and COVID-19: A Scoping Review. Eur J Dent. 2021;15(4):768-75. DOI:10.1055/s-0041-1729139
8. Grigoriadis A, Räisänen IT, Pärnänen P, et al. Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review. Eur J Dent. 2022;16(3):514-20.
DOI:10.1055/s-0041-1740223
9. Brock M, Bahammam S, Sima C. The Relationships Among Periodontitis, Pneumonia and COVID-19. Front Oral Health. 2022;2:801815. DOI:10.3389/froh.2021.801815
10. Salas Orozco MF, Niño-Martínez N, Martínez-Castañón GA, et al. Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review. Medicina (Kaunas). 2021;57(6):523. DOI:10.3390/medicina57060523
11. Gupta S, Mohindra R, Chauhan PK, et al. SARS-CoV-2 detection in gingival crevicular fluid. J Dent Res. 2021;100(2):187-93. DOI:10.1177/0022034520970536
12. Sahni V. SARS CoV-2 load in periodontal disease. J Am Dent Assoc. 2022;153(1):14. DOI:10.1016/j.adaj.2021.10.010
13. Berton F, Rupel K, Florian F, et al. Dental calculus: a reservoir for detection of past SARS-CoV-2 infection. Clin Oral Investig. 2021;25(8):5113-4. DOI:10.1007/s00784-021-04001-8
14. Gomes SC, Fachin S, da Fonseca JG, et al. Dental biofilm of symptomatic COVID-19 patients harbours SARS-CoV-2. J Clin Periodontol. 2021;48(7):880-5. DOI:10.1111/jcpe.13471
15. Gupta S, Mohindra R, Singla M, et al. The clinical association between Periodontitis and COVID-19. Clin Oral Investig. 2022;26(2):1361-74. DOI:10.1007/s00784-021-04111-3
16. Brandini DA, Takamiya AS, Thakkar P, et al. Covid-19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. 2021;31(6):e2226. DOI:10.1002/rmv.2226
17. Iranmanesh B, Khalili M, Amiri R, et al. Oral manifestations of COVID-19 disease: A review article. Dermatol Ther. 2021;34(1):e14578. DOI:10.1111/dth.14578
18. Daly J, Black EAM. The impact of COVID-19 on population oral health. Community Dent Health. 2020;37(4):236-8. DOI:10.1922/CDH_Dec20editorialDalyBlack03
19. Martín Carreras-Presas C, Amaro Sánchez J, López-Sánchez AF, et al. Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis. 2021;27(Suppl. 3):710-2. DOI:10.1111/odi.13382
20. Cuevas-Gonzalez MV, Espinosa-Cristóbal LF, Donohue-Cornejo A, et al. COVID-19 and its manifestations in the oral cavity: A systematic review. Medicine (Baltimore). 2021;100(51):e28327. DOI:10.1097/MD.0000000000028327
21. Farid H, Khan M, Jamal S, Ghafoor R. Oral manifestations of Covid-19-A literature review. Rev Med Virol. 2022;32(1):e2248. DOI:10.1002/rmv.2248
22. Eghbali Zarch R, Hosseinzadeh P. COVID-19 from the perspective of dentists: A case report and brief review of more than 170 cases. Dermatol Ther. 2021;34(1):e14717. DOI:10.1111/dth.14717
23. Surboyo MD, Ernawati DS, Budi HS. Oral mucosal lesions and oral symptoms of the SARS-CoV-2 infection. Minerva Dent Oral Sci. 2021;70(4):161-8.
DOI:10.23736/S2724-6329.21.04493-9
24. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral Manifestations in Patients with COVID-19: A 6-Month Update. J Dent Res. 2021;100(2):141-54. DOI:10.1177/0022034520957289
25. Doceda MV, Gavriiloglou M, Petit C, Huck O. Oral Health Implications of SARS-CoV-2/COVID-19: A Systematic Review. Oral Health Prev Dent. 2022;20(1):207-18. DOI:10.3290/j.ohpd.b2960801
26. Fakhruddin KS, Samaranayake LP, Buranawat B, Ngo H. Oro-facial mucocutaneous manifestations of Coronavirus Disease-2019 (COVID-19): A systematic review. PLoS One. 2022;17(6):e0265531. DOI:10.1371/journal.pone.0265531
27. Santana LADM, Vieira WA, Gonçalo RIC, et al. Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review. J Stomatol Oral Maxillofac Surg. 2022;123(5):e241-50. DOI:10.1016/j.jormas.2022.05.005
28. Sirin DA, Ozcelik F. The relationship between COVID-19 and the dental damage stage determined by radiological examination. Oral Radiol. 2021;37(4):600-9.
DOI:10.1007/s11282-020-00497-0
29. Qi X, Northridge ME, Hu M, Wu B. Oral health conditions and COVID-19: A systematic review and meta-analysis of the current evidence. Aging Health Res. 2022;2(1):100064. DOI:10.1016/j.ahr.2022.100064
30. Трухан Д.И., Трухан Л.Ю. Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке? Consilium Medicum. 2015;17(5):73-9. Режим доступа: https://elibrary.ru/item.asp?id=23762074. Ссылка активна на 26.05.2022 [Trukhan DI, Trukhan LYu. Periodontal and cardiovascular diseases: in parallel or in a bundle? Consilium Medicum. 2015;17(5):73-9. Available: https://elibrary.ru/item.asp?id=23762074. Accessed: 26.05.2022 (in Russian)].
31. Гришечкина И.А., Трухан Л.Ю., Трухан Д.И., Коншу Н.В. Оценка состояния гигиены полости рта и тканей пародонта у больных сахарным диабетом II типа. Dental Forum. 2014;3:45-50. Режим доступа: https://elibrary.ru/item.asp?id=21615957. Ссылка активна на 26.05.2022 [Grishechkina IA, Trukhan DI, Trukhan LYu, Konshu NV. Evaluation of oral hygiene and periodontal status in patients with type ii diabetes. Dental Forum. 2014;3:45-50. Available: https://elibrary.ru/item.asp?id=21615957. Accessed: 26.05.2022 (in Russian)].
32. Bascones-Martínez A, Muñoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc). 2015;145(1):31-5. DOI:10.1016/j.medcli.2014.07.019
33. Трухан Д.И., Трухан Л.Ю. Некоторые аспекты коморбидности пародонтита и сердечно-сосудистых заболеваний. Медицинский совет. 2015;17:12-6. Режим доступа: https://www.med-sovet.pro/jour/article/view/419. Ссылка активна на 26.05.2022 [Trukhan DI, Trukhan LYu. Some aspects of periodontal disease and comorbid cardiovascular diseases. Medical advice. 2015;17:12-6. Available: https://www.med-sovet.pro/jour/article/view/419. Accessed: 26.05.2022 (in Russian)].
34. Трухан Л.Ю., Трухан Д.И. Стоматологические проблемы гастроэнтерологических пациентов и возможные пути их решения. Медицинский совет. 2016;19:134-7. Режим доступа: https://www.med-sovet.pro/jour/article/view/1641. Ссылка активна на 26.05.2022 [Trukhan DI, Trukhan LYu. Stomatoligical problems of gastroenterological patients and their possible solutions. Medical advice. 2016;19:134-7. Available: https://www.med-sovet.pro/jour/article/view/1641. Accessed: 26.05.2022 (in Russian)].
35. Трухан Д.И., Трухан Л.Ю. Взаимоотношения болезней пародонта и сердечно-сосудистых заболеваний. Международный журнал сердца и сосудистых заболеваний. 2016;4(11):15-24. Режим доступа: http://heart-vdj.com/files/2016,%2011/t4n11_4.pdf. Ссылка активна на 26.05.2022 [Trukhan DI, Trukhan LYu. Relationship between periodontal and cardiovascular diseases. International Journal of Heart and Vascular Diseases. 2016;4(11):15-24. Available: http://heart-vdj.com/files/2016,%2011/t4n11_4.pdf. Accessed: 26.05.2022 (in Russian)].
36. Borgnakke WS. IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance. Diabetes Res Clin Pract. 2019;157:107839. DOI:10.1016/j.diabres.2019.107839.
37. Трухан Д.И., Трухан Л.Ю., Иванова Д.С. Коморбидность заболеваний сердечно-сосудистой системы и болезней органов пищеварения с изменениями органов и тканей полости рта. Клинический разбор в общей медицине. 2021;3:6-17 [Trukhan DI, Trukhan LYu, Ivanova DS. Comorbidity of diseases of the cardiovascular system and diseases of the digestive organs with changes in organs and tissue of the oral cavity. Clinical review for general practice. 2021;3:6-17 (in Russian)]. DOI:10.47407/kr2021.2.3.00044
38. Трухан Д.И., Иванова Д.С., Трухан Л.Ю. Гастроэнтерологические проблемы пациентов с сахарным диабетом. Focus Эндокринология. 2021;3:52-61 [Trukhan DI, Ivanova DS, Trukhan LYu. Gastroenterological problems of patients with diabetes mellitus. Focus Endokrinologiia. 2021;3:52-61 (in Russian)]. DOI:10.47407/ef2021.2.3.0035
39. Гриневич В.Б., Губонина И.В., Дощицин В.Л., и др. Особенности ведения коморбидных пациентов в период пандемии новой коронавирусной инфекции (COVID-19). Национальный Консенсус 2020. Кардиоваскулярная терапия и профилактика. 2020;19(4):2630 [Grinevich VB, Gubonina IV, Doshchitsin VL, et. al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020;19(4):2630 (in Russian)]. DOI:10.15829/1728-88002020-2630
40. Ghosh A, Joseph B, Anil S. Does periodontitis influence the risk of COVID-19? A scoping review. Clin Exp Dent Res. 2022. DOI:10.1002/cre2.584
41. Sahni V, Gupta S. COVID-19 & Periodontitis: The cytokine connection. Med Hypotheses. 2020;144:109908. DOI:10.1016/j.mehy.2020.109908
42. Marouf N, Cai W, Said KN, et al. Association between Periodontitis and Severity of COVID-19 Infection: A Case-Control Study. J Clin Periodontol. 2021;48(4):483-91. DOI:10.1111/jcpe.13435
43. Sukumar K, Tadepalli A. Nexus between COVID-19 and periodontal disease. J Int Med Res. 2021;49(3):3000605211002695. DOI:10.1177/03000605211002695
44. Bao L, Zhang C, Dong J, et al. Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection. Front Microbiol. 2020;11:1840. DOI:10.3389/fmicb.2020.01840
45. Aquino-Martinez R, Hernández-Vigueras S. Severe COVID-19 Lung Infection in Older People and Periodontitis. J Clin Med. 2021;10(2):279. DOI:10.3390/jcm10020279
46. Imai K, Iinuma T, Sato S. Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation. Jpn Dent Sci Rev. 2021;57:224-30. DOI:10.1016/j.jdsr.2021.10.003
47. Magán-Fernández A, O'Valle F, Abadía-Molina F, et al. Characterization and Comparison of Neutrophil Extracellular Traps in Gingival Samples of Periodontitis and Gingivitis: A Pilot Study. J Periodontal Res. 2019;54(3):218-24. DOI:10.1111/jre.12621
48. Borges L, Pithon-Curi TC, Curi R, Hatanaka E. COVID-19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps. Mediators Inflamm. 2020;2020:8829674. DOI:10.1155/2020/8829674
49. Gupta S, Sahni V. The intriguing commonality of NETosis between COVID-19 & Periodontal disease. Med Hypotheses. 2020;144:109968. DOI:10.1016/j.mehy.2020.109968
50. Magán-Fernández A, Rasheed Al-Bakri SM, O'Valle F, et al. Neutrophil Extracellular Traps in Periodontitis. Cells. 2020;9(6):1494. DOI:10.3390/cells9061494
51. Larvin H, Wilmott S, Wu J, Kang J. The impact of periodontal disease on hospital admission and mortality during COVID-19 pandemic. Front Med (Lausanne). 2020;7:604980. DOI:10.3389/fmed.2020.604980
52. Boyapati R, Dhulipalla R, Kolaparthy LK, Bodduru R. COVID-19 and oral implications: An updated review. J Oral Maxillofac Pathol. 2021;25(3):400-3. DOI:10.4103/jomfp.jomfp_198_21
53. Larvin H, Wilmott S, Kang J, et al. Additive Effect of Periodontal Disease and Obesity on COVID-19 Outcomes. J Dent Res. 2021;100(11):1228-35. DOI:10.1177/00220345211029638
54. Costa CA, Vilela ACS, Oliveira SA, et al. Poor oral health status and adverse COVID-19 outcomes: a preliminary study in hospitalized patients. J Periodontol. 2022:10.1002/JPER.21-0624. DOI:10.1002/JPER.21-0624
55. Anand PS, Jadhav P, Kamath KP, et al. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J Periodontol. 2022;93(4):584-90. DOI:10.1002/JPER.21-0272
56. Botros N, Iyer P, Ojcius DM. Is there an association between oral health and severity of COVID-19 complications? Biomed J. 2020;43(4):325-7. DOI:10.1016/j.bj.2020.05.016
57. Kouanda B, Sattar Z, Geraghty P. Periodontal Diseases: Major Exacerbators of Pulmonary Diseases? Pulm Med. 2021;2021:4712406. DOI:10.1155/2021/4712406
58. Wang Y, Deng H, Pan Y, et al. Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study. J Transl Med. 2021;19(1):528.
DOI:10.1186/s12967-021-03198-2
59. Трухан Д.И. Нарушения кишечного микробиоценоза: расширение сферы применения пробиотиков. Медицинский совет. 2022;16(7):132-43 [Trukhan DI. Disorders of intestinal microbiocenosis: expanding the application of probiotics. Meditsinskiy sovet. 2022;16(7):132-43 (in Russian)]. DOI:10.21518/2079-701X-2022-16-7-132-143
60. Khan AA, Singh H, Bilal M, Ashraf MT. Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19. Am J Transl Res. 2021;13(10):10977-93.
61. Di Pierro F. A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SAR S-CoV-2. Minerva Med. 2020;111(3):281-3.
DOI:10.23736/S0026-4806.20.06570-2
62. Di Pierro F, Colombo M. The administration of S. salivarius K12 to children may reduce the rate of SARS‑CoV-2 infection. Minerva Med. 2021;112(4):514-6.
DOI:10.23736/S0026-4806.21.07487-5
63. Wescombe PA, Hale JD, Heng NC, Tagg JR. Developing oral probiotics from Streptococcus salivarius. Future Microbiol. 2012;7(12):1355-71. DOI:10.2217/fmb.12.113
64. Horz HP, Meinelt A, Houben B, Conrads G. Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction. Oral Microbiol Immunol. 2007;22(2):126-30. DOI:10.1111/j.1399-302X.2007.00334.x
65. Di Pierro F, Adami T, Rapacioli G, et al. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013;13(3):339-43. DOI:10.1517/14712598.2013.758711
66. Cosseau C, Devine DA, Dullaghan E, et al. The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect Immun. 2008;76(9):4163-75. DOI:10.1128/IAI.00188-08
67. Laws GL, Hale JDF, Kemp RA. Human Systemic Immune Response to Ingestion of the Oral Probiotic Streptococcus salivarius BLIS K12. Probiotics Antimicrob Proteins. 2021;13(6):1521-9. DOI:10.1007/s12602-021-09822-3
68. Burton JP, Chilcott CN, Wescombe PA, Tagg JR. Extended Safety Data for the Oral Cavity Probiotic Streptococcus salivarius K12. Probiotics Antimicrob Proteins. 2010;2(3):135-44.
DOI:10.1007/s12602-010-9045-4
69. Burton JP, Cowley S, Simon RR, et al. Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study. Food Chem Toxicol. 2011;49(9):2356-64. DOI:10.1016/j.fct.2011.06.038
70. Di Pierro F, Risso P, Poggi E, et al. Use of Streptococcus salivarius K12 to reduce the incidence of pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. Minerva Pediatr. 2018;70(3):240-5. DOI:10.23736/S0026-4946.18.05182
71. Stašková A, Sondorová M, Nemcová R, et al. Antimicrobial and Antibiofilm Activity of the Probiotic Strain Streptococcus salivarius K12 against Oral Potential Pathogens. Antibiotics (Basel). 2021;10(7):793. DOI:10.3390/antibiotics10070793
72. Крючко Т.А., Ткаченко О.Я. Клинический опыт применения Streptococcus salivarius K12 в профилактике фаринготонзиллитов и респираторных инфекций у детей. Здоровье ребенка. 2018;7:629-34 [Kryuchko TO, Tkachenko OYa. Clinical experience of Streptococcus salivarius K12 use for the prevention of pharyngotonsillitis and respiratory infections in children. Zdorov'e rebenka. 2018;7:629-34 (in Russian)]. DOI:10.22141/2224-0551.13.7.2018.148915
73. Ильченко С.И., Фиалковская А.А., Можейко Т.В. О профилактике рекуррентных респираторных заболеваний у детей с микроаспирационным синдромом. Педиатрия. Восточная Европа. 2019;4:680-7. Режим доступа: https://www.elibrary.ru/item.asp?id=41411891. Ссылка активна на 26.05.2022 [Ilchenko SI, Fialkovskaia AA, Mozheiko TV. Prevention of recurrent respiratory diseases in children with microaspiration syndrome. Pediatrics. Eastern Europe. 2019;4:680-7. Available: https://www.elibrary.ru/item.asp?id=41411891. Accessed: 26.05.2022 (in Russian)].
74. Крамарев С.А., Евтушенко В.В. Бактоблис® (Streptococcus salivarius K12) – инновационная терапия и профилактика острых респираторных инфекций и их осложнений. Актуальная инфектология. 2020;1:50-3 [Kramarev SA, Yevtushenko VV. Bactoblis® (Streptococcus salivarius K12) – innovative therapy and prevention of acute respiratory infections and their complications. Aktual'naia infektologiia. 2020;1:50-3 (in Russian)]. DOI:10.22141/2312-413x.8.1.2020.196172
75. Ильченко С.И., Фиалковская А.А., Можейко Т.В. О профилактике рекуррентных респираторных заболеваний у детей с микроаспирационным синдромом. Оториноларингология. Восточная Европа. 2020;3:278-85 [Ilchenko SI, Fialkovskaia AA, Mozheiko TV. Prevention of recurrent respiratory diseases in children with microaspiration syndrome. Otorinolaringologiia. Vostochnaia Evropa. 2020;3:278-85 (in Russian)]. DOI:10.34883/PI.2020.10.3.051
76. Крючко Т.А., Ткаченко О.Я., Несина И.Н., и др. Пути оптимизации лечения детей с заболеваниями дыхательных путей и лор-органов. Педиатрия. Восточная Европа. 2021;3:482-91 [Kryuchko TA, Tkachenko OYa, Nesina IN, et al. Ways to Optimize the Treatment of Children with Diseases of the Respiratory Tract. Pediatriia. Vostochnaia Evropa. 2021;3:482-91 (in Russian)]. DOI:10.34883/PI.2021.9.3.015
77. Овчинников А.Ю., Мирошниченко Н.А., Егиян С.С., Акопян Л.В. Возможности пробиотической терапии при хронических воспалительных заболеваниях ротоглотки. Эффективная фармакотерапия. 2022;4:24-8 [Ovchinnikov AYu, Miroshnichenko NA, Egiyan SS, Akopyan LV. Possibilities of Probiotic Therapy in Chronic Inflammatory Diseases of the Oropharynx. Effektivnaia farmakoterapiia. 2022;4:24-8 (in Russian)]. DOI:10.33978/2307-3586-2022-18-4-24-28
78. Zupancic K, Kriksic V, Kovacevic I, Kovacevic D. Influence of Oral Probiotic Streptococcus salivarius K12 on Ear and Oral Cavity Health in Humans: Systematic Review. Probiotics Antimicrob Proteins. 2017;9(2):102-10. DOI:10.1007/s12602-017-9261-2
79. Wilcox CR, Stuart B, Leaver H, et al. Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review. Clin Microbiol Infect. 2019;25(6):673-80. DOI:10.1016/j.cmi.2018.12.031
80. Marini G, Sitzia E, Panatta ML, De Vincentiis GC. Pilot study to explore the prophylactic efficacy of oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngo-tonsillar episodes in pediatric patients. Int J Gen Med. 2019;12:213-7. DOI:10.2147/IJGM.S168209
81. Крамарев С.А., Евтушенко В.В., Серякова И.Ю., Каминская Т.Н. Применение пробиотического штамма Streptococcus salivarius K12 в лечении острых тонзиллофарингитов у детей. Актуальная инфектология. 2020;3-4:29-34 [Kramarov SO, Yevtushenko VV, Seryakova IYu, Kaminskaya TN. Application of Streptococcus salivarius K12 probiotic strain in the treatment of acute tonsillopharyngitis in children. Actual infectology. 2020;3-4:29-34 (in Russian)]. DOI:10.22141/2312-413x.8.3-4.2020.212657
82. Chen TY, Hale JDF, Tagg JR, et al. In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12. Probiotics Antimicrob Proteins. 2021;13(3):734-8. DOI:10.1007/s12602-020-09719-7
83. Ковалева А.Ю., Эйдельштейн И.А., Ковалева Н.С. Эффективность применения пробиотика бактоблис для профилактики заболеваний полости рта. В сборнике: Актуальные проблемы детской стоматологии и ортодонтии. Сборник научных статей XI международной научно-практической конференции по детской стоматологии в рамках IV Дальневосточного Стоматологического конгресса. Хабаровск, 2021; c. 101-4. Режим доступа: https://www.elibrary.ru/item.asp?id=48267079. Ссылка активна на 26.05.2022 [Kovaleva A.Iu., Eidel'shtein I.A., Kovaleva N.S. Effektivnost' primeneniia probiotika baktoblis dlia profilaktiki zabolevanii polosti rta. V sbornike: Aktual'nye problemy detskoi stomatologii i ortodontii. Sbornik nauchnykh statei XI mezhdunarodnoi nauchno-prakticheskoi konferentsii po detskoi stomatologii v ramkakh IV Dal'nevostochnogo Stomatologicheskogo kongressa. Khabarovsk, 2021; p. 101-4. Available: https://www.elibrary.ru/item.asp?id=48267079. Accessed: 26.05.2022 (in Russian)].
84. Караков К.Г., Власова Т.Н., Оганян А.В., и др. Критерии выбора метода коррекции дисбактериоза органов полости рта. Проблемы стоматологии. 2020;2:17-21 [Karakov KG, Vlasova TN, Oganyan AV, et al. Criteria for choosing the method of correction of disbacteriosis of authorities oral cavity. Problemy stomatologii. 2020;2:17-21 (in Russian)]. DOI:10.18481/2077-7566-20-16-2-17-21
85. Li Y, Shao F, Zheng S, et al. Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment. Probiotics Antimicrob Proteins. 2020;12(4):1340-8. DOI:10.1007/s12602-020-09664-5
86. He L, Yang H, Chen Z, Ouyang X. The Effect of Streptococcus salivarius K12 on Halitosis: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2020;12(4):1321-9. DOI:10.1007/s12602-020-09646-7
87. Mokhtar M, Rismayuddin NAR, Mat Yassim AS, et al. Streptococcus salivarius K12 inhibits Candida albicans aggregation, biofilm formation and dimorphism. Biofouling. 2021;37(7):767-76. DOI:10.1080/08927014.2021.1967334
88. Burton JP, Chilcott CN, Tagg JR. The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics. Oral Dis. 2005;11(Suppl. 1):29-31. DOI:10.1111/j.1601-0825.2005.01084.x
89. Masdea L, Kulik EM, Hauser-Gerspach I, et al. Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodour. Arch Oral Biol. 2012;57(8):1041-7. DOI:10.1016/j.archoralbio.2012.02.011
90. Савлевич Е.Л., Дорощенко Н.Э., Жарких М.А., и др. Коррекция галитоза при хронических воспалительных заболеваниях ротоглотки у взрослых. Вестник оториноларингологии. 2021;6:41-6 [Savlevich EL, Doroshchenko NE, Zharkikh MA, et al. Correction of halitosis in chronic inflammatory diseases of the oropharynx in adults. 2021;6:41-6 (in Russian)]. DOI:10.17116/otorino20218606141
91. Burton JP, Wescombe PA, Moore CJ, et al. Safety assessment of the oral cavity probiotic Streptococcus salivarius K12. Appl Environ Microbiol. 2006;72(4):3050-3. DOI:10.1128/AEM.72.4.3050-3053.2006
92. Sarlin S, Tejesvi MV, Turunen J, et al. Impact of Streptococcus salivarius K12 on Nasopharyngeal and Saliva Microbiome: A Randomized Controlled Trial. Pediatr Infect Dis J. 2021;40(5):394-402. DOI:10.1097/INF.0000000000003016
93. Hale JDF, Jain R, Wescombe PA, et al. Safety assessment of Streptococcus salivarius M18 a probiotic for oral health. Benef Microbes. 2022;13(1):47-60. DOI:10.3920/BM2021.0107
94. Di Pierro F, Zanvit A, Nobili P, et al. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study. Clin Cosmet Investig Dent. 2015;7:107-13. DOI:10.2147/CCIDE.S93066.
95. Кисельникова Л.П., Царев В.Н., Тома Э.И., Подпорин М.С. Клинико-микробиологическая характеристика микробиоценоза полости рта детей и возможности его коррекции с применением пробиотиков на основе саливарных стрептококков. Клиническая стоматология. 2021;4:24-9 [Kisel'nikova LP, Tsarev VN, Toma EI, Podporin MS. Kliniko-mikrobiologicheskaia kharakteristika mikrobiotsenoza polosti rta detei i vozmozhnosti ego korrektsii s primeneniem probiotikov na osnove salivarnykh streptokokkov. Klinicheskaia stomatologiia. 2021;4:24-9 (in Russian)]. DOI:10.37988/1811-153X_2021_4_24
96. Tunçer S, Karaçam S. Cell-free supernatant of Streptococcus salivarius M18 impairs the pathogenic properties of Pseudomonas aeruginosa and Klebsiella pneumonia. Arch Microbiol. 2020;202(10):2825-40. DOI:10.1007/s00203-020-02005-8
97. Karaçam S, Tunçer S. Exploiting the Acidic Extracellular pH: Evaluation of Streptococcus salivarius M18 Postbiotics to Target Cancer Cells. Probiotics Antimicrob Proteins. 2021.
DOI:10.1007/s12602-021-09806-3
98. Burton JP, Drummond BK, Chilcott CN, et al. Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: a randomized double-blind, placebo-controlled trial. J Med Microbiol. 2013;62(Pt 6):875-84. DOI:10.1099/jmm.0.056663-0
99. Bardellini E, Amadori F, Gobbi E, et al. Does Streptococcus Salivarius Strain M18 Assumption Make Black Stains Disappear in Children? Oral Health Prev Dent. 2020;18(1):161-4. DOI:10.3290/j.ohpd.a43359
100. Gobbi E, De Francesco MA, Piccinelli G, et al. In vitro inhibitory effect of two commercial probiotics on chromogenic actinomycetes. Eur Arch Paediatr Dent. 2020;21(6):673-7. DOI:10.1007/s40368-020-00512-2
101. Гажва С.И., Белоусова Е.Ю. Особенности лечения стоматологических заболеваний у детей с расстройствами аутистического спектра на фоне дисбиозов.В сборнике: Стоматологическая весна в Белгороде – 2021. Сборник трудов Международной научной конференции молодых ученых, работающих в области стоматологии, приуроченная к году науки и технологий. Белгород, 2021; с. 36-7. Режим доступа: https://elibrary.ru/item.asp?id=48509394. Ссылка активна на 26.05.2022 [Gazhva SI, Belousova EYu. Features of the treatment of dental diseases in children with autism spectrum disorders against the background of dysbiosis. In the collection: Dental Spring in Belgorod – 2021. Proceedings of the International Scientific Conference of Young Scientists Working in the Field of Dentistry, dedicated to the year of science and technology. Belgorod, 2021; p. 36-7. Available: https://elibrary.ru/item.asp?id=48509394. Accessed: 26.05.2022 (in Russian)].
102. Benic GZ, Farella M, Morgan XC, et al. Oral probiotics reduce halitosis in patients wearing orthodontic braces: a randomized, triple-blind, placebo-controlled trial. J Breath Res. 2019;13(3):036010. DOI:10.1088/1752-7163/ab1c81
103. Кравец О.Н., Дерябина Л.В. Клиническая оценка эффективности применения пробиотика на основе Streptococcus salivarius M18 при лечении хронического генерализованного пародонтита легкой степени тяжести. Проблемы медицинской микологии. 2021;23(2):96. Режим доступа: https://elibrary.ru/item.asp?id=46212960. Ссылка активна на 26.05.2022 [Kravets ON, Deryabina LV. Clinical evaluation of the effectiveness of probiotics based on Streptococcus salivarius M18 in treatment of periodontal diseases. Problems of medical mycology. 2021;23(2):96. Available: https://elibrary.ru/item.asp?id=46212960. Accessed: 26.05.2022 (in Russian)].
104. Manning J, Dunne EM, Wescombe PA, et al. Investigation of Streptococcus salivarius-mediated inhibition of pneumococcal adherence to pharyngeal epithelial cells. BMC Microbiol. 2016;16(1):225. DOI:10.1186/s12866-016-0843-z
105. Yoo HJ, Jwa SK, Kim DH, Ji YJ. Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro. Clin Exp Dent Res. 2020;6(2):207-14. DOI:10.1002/cre2.269
106. MacDonald KW, Chanyi RM, Macklaim JM, et al. Streptococcus salivarius inhibits immune activation by periodontal disease pathogens. BMC Oral Health. 2021;21(1):245. DOI:10.1186/s12903-021-01606-z
107. Poorni S, Nivedhitha MS, Srinivasan M, Balasubramaniam A. Effect of Probiotic Streptococcus salivarius K12 and M18 Lozenges on the Cariogram Parameters of Patients With High Caries Risk: A Randomised Control Trial. Cureus. 2022;14(3):e23282. DOI:10.7759/cureus.23282
108. Jansen PM, Abdelbary MMH, Conrads G. A concerted probiotic activity to inhibit periodontitis-associated bacteria. PLoS One. 2021;16(3):e0248308. DOI:10.1371/journal.pone.0248308
109. Borsche L, Glauner B, von Mendel J. COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis. Nutrients. 2021;13(10):3596. DOI:10.3390/nu13103596
110. Varikasuvu SR, Thangappazham B, Vykunta A, et al. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022;20(6):907-13. DOI:10.1080/14787210.2022.2035217
111. Cui X, Zhai Y, Wang S, et al. Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review and Meta-Analysis. Med Sci Monit. 2022;28:e935823. DOI:10.12659/MSM.935823
112. Youssef M, Ahmed HY, Zongo A, et al. Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases. Int J Mol Sci. 202;22(20):11290. DOI:10.3390/ijms222011290
113. Cunningham M, Azcarate-Peril MA, Barnard A, et al. Shaping the Future of Probiotics and Prebiotics. Trends Microbiol. 2021;29(8):667-85. DOI:10.1016/j.tim.2021.01.003
________________________________________________
1. Vremennye metodicheskie rekomendatsii Minzdrava RF "Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19)" (15-ia versiia ot 22.02.2022). Available: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/392/original/%D0%92%D0%9C%D0%A0.... Accessed: 26.05.2022 (in Russian).
2. Casillas Santana MA, Arreguín Cano JA, Dib Kanán A, et al. Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis. Medicina (Kaunas). 2021;57(5):493. DOI:10.3390/medicina57050493
3. Silvestre FJ, Márquez-Arrico CF. COVID-19 and Periodontitis: A Dangerous Association? Front Pharmacol. 2022;12:789681. DOI:10.3389/fphar.2021.789681
4. Jafer MA, Hazazi MA, Mashi MH, et al. COVID-19 and Periodontitis: A Reality to Live with. J Contemp Dent Pract. 2020;21(12):1398-403.
5. Campisi G, Bizzoca ME, Lo Muzio L. COVID-19 and periodontitis: reflecting on a possible association. Head Face Med. 2021;17(1):16. DOI:10.1186/s13005-021-00267-1
6. Kusiak A, Cichońska D, Tubaja M, et al. COVID-19 manifestation in the oral cavity – a narrative literature review. Acta Otorhinolaryngol Ital. 2021;41(5):395-400.
DOI:10.14639/0392-100X-N1584
7. Basso L, Chacun D, Sy K, et al. Periodontal Diseases and COVID-19: A Scoping Review. Eur J Dent. 2021;15(4):768-75. DOI:10.1055/s-0041-1729139
8. Grigoriadis A, Räisänen IT, Pärnänen P, et al. Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review. Eur J Dent. 2022;16(3):514-20.
DOI:10.1055/s-0041-1740223
9. Brock M, Bahammam S, Sima C. The Relationships Among Periodontitis, Pneumonia and COVID-19. Front Oral Health. 2022;2:801815. DOI:10.3389/froh.2021.801815
10. Salas Orozco MF, Niño-Martínez N, Martínez-Castañón GA, et al. Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review. Medicina (Kaunas). 2021;57(6):523. DOI:10.3390/medicina57060523
11. Gupta S, Mohindra R, Chauhan PK, et al. SARS-CoV-2 detection in gingival crevicular fluid. J Dent Res. 2021;100(2):187-93. DOI:10.1177/0022034520970536
12. Sahni V. SARS CoV-2 load in periodontal disease. J Am Dent Assoc. 2022;153(1):14. DOI:10.1016/j.adaj.2021.10.010
13. Berton F, Rupel K, Florian F, et al. Dental calculus: a reservoir for detection of past SARS-CoV-2 infection. Clin Oral Investig. 2021;25(8):5113-4. DOI:10.1007/s00784-021-04001-8
14. Gomes SC, Fachin S, da Fonseca JG, et al. Dental biofilm of symptomatic COVID-19 patients harbours SARS-CoV-2. J Clin Periodontol. 2021;48(7):880-5. DOI:10.1111/jcpe.13471
15. Gupta S, Mohindra R, Singla M, et al. The clinical association between Periodontitis and COVID-19. Clin Oral Investig. 2022;26(2):1361-74. DOI:10.1007/s00784-021-04111-3
16. Brandini DA, Takamiya AS, Thakkar P, et al. Covid-19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. 2021;31(6):e2226. DOI:10.1002/rmv.2226
17. Iranmanesh B, Khalili M, Amiri R, et al. Oral manifestations of COVID-19 disease: A review article. Dermatol Ther. 2021;34(1):e14578. DOI:10.1111/dth.14578
18. Daly J, Black EAM. The impact of COVID-19 on population oral health. Community Dent Health. 2020;37(4):236-8. DOI:10.1922/CDH_Dec20editorialDalyBlack03
19. Martín Carreras-Presas C, Amaro Sánchez J, López-Sánchez AF, et al. Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis. 2021;27(Suppl. 3):710-2. DOI:10.1111/odi.13382
20. Cuevas-Gonzalez MV, Espinosa-Cristóbal LF, Donohue-Cornejo A, et al. COVID-19 and its manifestations in the oral cavity: A systematic review. Medicine (Baltimore). 2021;100(51):e28327. DOI:10.1097/MD.0000000000028327
21. Farid H, Khan M, Jamal S, Ghafoor R. Oral manifestations of Covid-19-A literature review. Rev Med Virol. 2022;32(1):e2248. DOI:10.1002/rmv.2248
22. Eghbali Zarch R, Hosseinzadeh P. COVID-19 from the perspective of dentists: A case report and brief review of more than 170 cases. Dermatol Ther. 2021;34(1):e14717. DOI:10.1111/dth.14717
23. Surboyo MD, Ernawati DS, Budi HS. Oral mucosal lesions and oral symptoms of the SARS-CoV-2 infection. Minerva Dent Oral Sci. 2021;70(4):161-8.
DOI:10.23736/S2724-6329.21.04493-9
24. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral Manifestations in Patients with COVID-19: A 6-Month Update. J Dent Res. 2021;100(2):141-54. DOI:10.1177/0022034520957289
25. Doceda MV, Gavriiloglou M, Petit C, Huck O. Oral Health Implications of SARS-CoV-2/COVID-19: A Systematic Review. Oral Health Prev Dent. 2022;20(1):207-18. DOI:10.3290/j.ohpd.b2960801
26. Fakhruddin KS, Samaranayake LP, Buranawat B, Ngo H. Oro-facial mucocutaneous manifestations of Coronavirus Disease-2019 (COVID-19): A systematic review. PLoS One. 2022;17(6):e0265531. DOI:10.1371/journal.pone.0265531
27. Santana LADM, Vieira WA, Gonçalo RIC, et al. Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review. J Stomatol Oral Maxillofac Surg. 2022;123(5):e241-50. DOI:10.1016/j.jormas.2022.05.005
28. Sirin DA, Ozcelik F. The relationship between COVID-19 and the dental damage stage determined by radiological examination. Oral Radiol. 2021;37(4):600-9.
DOI:10.1007/s11282-020-00497-0
29. Qi X, Northridge ME, Hu M, Wu B. Oral health conditions and COVID-19: A systematic review and meta-analysis of the current evidence. Aging Health Res. 2022;2(1):100064. DOI:10.1016/j.ahr.2022.100064
30. Trukhan DI, Trukhan LYu. Periodontal and cardiovascular diseases: in parallel or in a bundle? Consilium Medicum. 2015;17(5):73-9. Available: https://elibrary.ru/item.asp?id=23762074. Accessed: 26.05.2022 (in Russian).
31. Grishechkina IA, Trukhan DI, Trukhan LYu, Konshu NV. Evaluation of oral hygiene and periodontal status in patients with type ii diabetes. Dental Forum. 2014;3:45-50. Available: https://elibrary.ru/item.asp?id=21615957. Accessed: 26.05.2022 (in Russian).
32. Bascones-Martínez A, Muñoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc). 2015;145(1):31-5. DOI:10.1016/j.medcli.2014.07.019
33. Trukhan DI, Trukhan LYu. Some aspects of periodontal disease and comorbid cardiovascular diseases. Medical advice. 2015;17:12-6. Available: https://www.med-sovet.pro/jour/article/view/419. Accessed: 26.05.2022 (in Russian).
34. Trukhan DI, Trukhan LYu. Stomatoligical problems of gastroenterological patients and their possible solutions. Medical advice. 2016;19:134-7. Available: https://www.med-sovet.pro/jour/article/view/1641. Accessed: 26.05.2022 (in Russian).
35. Trukhan DI, Trukhan LYu. Relationship between periodontal and cardiovascular diseases. International Journal of Heart and Vascular Diseases. 2016;4(11):15-24. Available: http://heart-vdj.com/files/2016,%2011/t4n11_4.pdf. Accessed: 26.05.2022 (in Russian).
36. Borgnakke WS. IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance. Diabetes Res Clin Pract. 2019;157:107839. DOI:10.1016/j.diabres.2019.107839.
37. Trukhan DI, Trukhan LYu, Ivanova DS. Comorbidity of diseases of the cardiovascular system and diseases of the digestive organs with changes in organs and tissue of the oral cavity. Clinical review for general practice. 2021;3:6-17 (in Russian). DOI:10.47407/kr2021.2.3.00044
38. Trukhan DI, Ivanova DS, Trukhan LYu. Gastroenterological problems of patients with diabetes mellitus. Focus Endokrinologiia. 2021;3:52-61 (in Russian). DOI:10.47407/ef2021.2.3.0035
39. Grinevich VB, Gubonina IV, Doshchitsin VL, et. al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020;19(4):2630 (in Russian). DOI:10.15829/1728-88002020-2630
40. Ghosh A, Joseph B, Anil S. Does periodontitis influence the risk of COVID-19? A scoping review. Clin Exp Dent Res. 2022. DOI:10.1002/cre2.584
41. Sahni V, Gupta S. COVID-19 & Periodontitis: The cytokine connection. Med Hypotheses. 2020;144:109908. DOI:10.1016/j.mehy.2020.109908
42. Marouf N, Cai W, Said KN, et al. Association between Periodontitis and Severity of COVID-19 Infection: A Case-Control Study. J Clin Periodontol. 2021;48(4):483-91. DOI:10.1111/jcpe.13435
43. Sukumar K, Tadepalli A. Nexus between COVID-19 and periodontal disease. J Int Med Res. 2021;49(3):3000605211002695. DOI:10.1177/03000605211002695
44. Bao L, Zhang C, Dong J, et al. Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection. Front Microbiol. 2020;11:1840. DOI:10.3389/fmicb.2020.01840
45. Aquino-Martinez R, Hernández-Vigueras S. Severe COVID-19 Lung Infection in Older People and Periodontitis. J Clin Med. 2021;10(2):279. DOI:10.3390/jcm10020279
46. Imai K, Iinuma T, Sato S. Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation. Jpn Dent Sci Rev. 2021;57:224-30. DOI:10.1016/j.jdsr.2021.10.003
47. Magán-Fernández A, O'Valle F, Abadía-Molina F, et al. Characterization and Comparison of Neutrophil Extracellular Traps in Gingival Samples of Periodontitis and Gingivitis: A Pilot Study. J Periodontal Res. 2019;54(3):218-24. DOI:10.1111/jre.12621
48. Borges L, Pithon-Curi TC, Curi R, Hatanaka E. COVID-19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps. Mediators Inflamm. 2020;2020:8829674. DOI:10.1155/2020/8829674
49. Gupta S, Sahni V. The intriguing commonality of NETosis between COVID-19 & Periodontal disease. Med Hypotheses. 2020;144:109968. DOI:10.1016/j.mehy.2020.109968
50. Magán-Fernández A, Rasheed Al-Bakri SM, O'Valle F, et al. Neutrophil Extracellular Traps in Periodontitis. Cells. 2020;9(6):1494. DOI:10.3390/cells9061494
51. Larvin H, Wilmott S, Wu J, Kang J. The impact of periodontal disease on hospital admission and mortality during COVID-19 pandemic. Front Med (Lausanne). 2020;7:604980. DOI:10.3389/fmed.2020.604980
52. Boyapati R, Dhulipalla R, Kolaparthy LK, Bodduru R. COVID-19 and oral implications: An updated review. J Oral Maxillofac Pathol. 2021;25(3):400-3. DOI:10.4103/jomfp.jomfp_198_21
53. Larvin H, Wilmott S, Kang J, et al. Additive Effect of Periodontal Disease and Obesity on COVID-19 Outcomes. J Dent Res. 2021;100(11):1228-35. DOI:10.1177/00220345211029638
54. Costa CA, Vilela ACS, Oliveira SA, et al. Poor oral health status and adverse COVID-19 outcomes: a preliminary study in hospitalized patients. J Periodontol. 2022:10.1002/JPER.21-0624. DOI:10.1002/JPER.21-0624
55. Anand PS, Jadhav P, Kamath KP, et al. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J Periodontol. 2022;93(4):584-90. DOI:10.1002/JPER.21-0272
56. Botros N, Iyer P, Ojcius DM. Is there an association between oral health and severity of COVID-19 complications? Biomed J. 2020;43(4):325-7. DOI:10.1016/j.bj.2020.05.016
57. Kouanda B, Sattar Z, Geraghty P. Periodontal Diseases: Major Exacerbators of Pulmonary Diseases? Pulm Med. 2021;2021:4712406. DOI:10.1155/2021/4712406
58. Wang Y, Deng H, Pan Y, et al. Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study. J Transl Med. 2021;19(1):528.
DOI:10.1186/s12967-021-03198-2
59. Trukhan DI. Disorders of intestinal microbiocenosis: expanding the application of probiotics. Meditsinskiy sovet. 2022;16(7):132-43 (in Russian).
DOI:10.21518/2079-701X-2022-16-7-132-143
60. Khan AA, Singh H, Bilal M, Ashraf MT. Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19. Am J Transl Res. 2021;13(10):10977-93.
61. Di Pierro F. A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SAR S-CoV-2. Minerva Med. 2020;111(3):281-3.
DOI:10.23736/S0026-4806.20.06570-2
62. Di Pierro F, Colombo M. The administration of S. salivarius K12 to children may reduce the rate of SARS‑CoV-2 infection. Minerva Med. 2021;112(4):514-6.
DOI:10.23736/S0026-4806.21.07487-5
63. Wescombe PA, Hale JD, Heng NC, Tagg JR. Developing oral probiotics from Streptococcus salivarius. Future Microbiol. 2012;7(12):1355-71. DOI:10.2217/fmb.12.113
64. Horz HP, Meinelt A, Houben B, Conrads G. Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction. Oral Microbiol Immunol. 2007;22(2):126-30. DOI:10.1111/j.1399-302X.2007.00334.x
65. Di Pierro F, Adami T, Rapacioli G, et al. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013;13(3):339-43. DOI:10.1517/14712598.2013.758711
66. Cosseau C, Devine DA, Dullaghan E, et al. The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect Immun. 2008;76(9):4163-75. DOI:10.1128/IAI.00188-08
67. Laws GL, Hale JDF, Kemp RA. Human Systemic Immune Response to Ingestion of the Oral Probiotic Streptococcus salivarius BLIS K12. Probiotics Antimicrob Proteins. 2021;13(6):1521-9. DOI:10.1007/s12602-021-09822-3
68. Burton JP, Chilcott CN, Wescombe PA, Tagg JR. Extended Safety Data for the Oral Cavity Probiotic Streptococcus salivarius K12. Probiotics Antimicrob Proteins. 2010;2(3):135-44.
DOI:10.1007/s12602-010-9045-4
69. Burton JP, Cowley S, Simon RR, et al. Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study. Food Chem Toxicol. 2011;49(9):2356-64. DOI:10.1016/j.fct.2011.06.038
70. Di Pierro F, Risso P, Poggi E, et al. Use of Streptococcus salivarius K12 to reduce the incidence of pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. Minerva Pediatr. 2018;70(3):240-5. DOI:10.23736/S0026-4946.18.05182
71. Stašková A, Sondorová M, Nemcová R, et al. Antimicrobial and Antibiofilm Activity of the Probiotic Strain Streptococcus salivarius K12 against Oral Potential Pathogens. Antibiotics (Basel). 2021;10(7):793. DOI:10.3390/antibiotics10070793
72. Kryuchko TO, Tkachenko OYa. Clinical experience of Streptococcus salivarius K12 use for the prevention of pharyngotonsillitis and respiratory infections in children. Zdorov'e rebenka. 2018;7:629-34 (in Russian). DOI:10.22141/2224-0551.13.7.2018.148915
73. Ilchenko SI, Fialkovskaia AA, Mozheiko TV. Prevention of recurrent respiratory diseases in children with microaspiration syndrome. Pediatrics. Eastern Europe. 2019;4:680-7. Available: https://www.elibrary.ru/item.asp?id=41411891. Accessed: 26.05.2022 (in Russian).
74. Kramarev SA, Yevtushenko VV. Bactoblis® (Streptococcus salivarius K12) – innovative therapy and prevention of acute respiratory infections and their complications. Aktual'naia infektologiia. 2020;1:50-3 (in Russian). DOI:10.22141/2312-413x.8.1.2020.196172
75. Ilchenko SI, Fialkovskaia AA, Mozheiko TV. Prevention of recurrent respiratory diseases in children with microaspiration syndrome. Otorinolaringologiia. Vostochnaia Evropa. 2020;3:278-85 (in Russian). DOI:10.34883/PI.2020.10.3.051
76. Kryuchko TA, Tkachenko OYa, Nesina IN, et al. Ways to Optimize the Treatment of Children with Diseases of the Respiratory Tract. Pediatriia. Vostochnaia Evropa. 2021;3:482-91 (in Russian). DOI:10.34883/PI.2021.9.3.015
77. Ovchinnikov AYu, Miroshnichenko NA, Egiyan SS, Akopyan LV. Possibilities of Probiotic Therapy in Chronic Inflammatory Diseases of the Oropharynx. Effektivnaia farmakoterapiia. 2022;4:24-8 (in Russian). DOI:10.33978/2307-3586-2022-18-4-24-28
78. Zupancic K, Kriksic V, Kovacevic I, Kovacevic D. Influence of Oral Probiotic Streptococcus salivarius K12 on Ear and Oral Cavity Health in Humans: Systematic Review. Probiotics Antimicrob Proteins. 2017;9(2):102-10. DOI:10.1007/s12602-017-9261-2
79. Wilcox CR, Stuart B, Leaver H, et al. Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review. Clin Microbiol Infect. 2019;25(6):673-80. DOI:10.1016/j.cmi.2018.12.031
80. Marini G, Sitzia E, Panatta ML, De Vincentiis GC. Pilot study to explore the prophylactic efficacy of oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngo-tonsillar episodes in pediatric patients. Int J Gen Med. 2019;12:213-7. DOI:10.2147/IJGM.S168209
81. Kramarov SO, Yevtushenko VV, Seryakova IYu, Kaminskaya TN. Application of Streptococcus salivarius K12 probiotic strain in the treatment of acute tonsillopharyngitis in children. Actual infectology. 2020;3-4:29-34 (in Russian). DOI:10.22141/2312-413x.8.3-4.2020.212657
82. Chen TY, Hale JDF, Tagg JR, et al. In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12. Probiotics Antimicrob Proteins. 2021;13(3):734-8. DOI:10.1007/s12602-020-09719-7
83. Kovaleva A.Iu., Eidel'shtein I.A., Kovaleva N.S. Effektivnost' primeneniia probiotika baktoblis dlia profilaktiki zabolevanii polosti rta. V sbornike: Aktual'nye problemy detskoi stomatologii i ortodontii. Sbornik nauchnykh statei XI mezhdunarodnoi nauchno-prakticheskoi konferentsii po detskoi stomatologii v ramkakh IV Dal'nevostochnogo Stomatologicheskogo kongressa. Khabarovsk, 2021; p. 101-4. Available: https://www.elibrary.ru/item.asp?id=48267079. Accessed: 26.05.2022 (in Russian).
84. Karakov KG, Vlasova TN, Oganyan AV, et al. Criteria for choosing the method of correction of disbacteriosis of authorities oral cavity. Problemy stomatologii. 2020;2:17-21 (in Russian). DOI:10.18481/2077-7566-20-16-2-17-21
85. Li Y, Shao F, Zheng S, et al. Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment. Probiotics Antimicrob Proteins. 2020;12(4):1340-8. DOI:10.1007/s12602-020-09664-5
86. He L, Yang H, Chen Z, Ouyang X. The Effect of Streptococcus salivarius K12 on Halitosis: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2020;12(4):1321-9. DOI:10.1007/s12602-020-09646-7
87. Mokhtar M, Rismayuddin NAR, Mat Yassim AS, et al. Streptococcus salivarius K12 inhibits Candida albicans aggregation, biofilm formation and dimorphism. Biofouling. 2021;37(7):767-76. DOI:10.1080/08927014.2021.1967334
88. Burton JP, Chilcott CN, Tagg JR. The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics. Oral Dis. 2005;11(Suppl. 1):29-31. DOI:10.1111/j.1601-0825.2005.01084.x
89. Masdea L, Kulik EM, Hauser-Gerspach I, et al. Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodour. Arch Oral Biol. 2012;57(8):1041-7. DOI:10.1016/j.archoralbio.2012.02.011
90. Savlevich EL, Doroshchenko NE, Zharkikh MA, et al. Correction of halitosis in chronic inflammatory diseases of the oropharynx in adults. 2021;6:41-6 (in Russian). DOI:10.17116/otorino20218606141
91. Burton JP, Wescombe PA, Moore CJ, et al. Safety assessment of the oral cavity probiotic Streptococcus salivarius K12. Appl Environ Microbiol. 2006;72(4):3050-3. DOI:10.1128/AEM.72.4.3050-3053.2006
92. Sarlin S, Tejesvi MV, Turunen J, et al. Impact of Streptococcus salivarius K12 on Nasopharyngeal and Saliva Microbiome: A Randomized Controlled Trial. Pediatr Infect Dis J. 2021;40(5):394-402. DOI:10.1097/INF.0000000000003016
93. Hale JDF, Jain R, Wescombe PA, et al. Safety assessment of Streptococcus salivarius M18 a probiotic for oral health. Benef Microbes. 2022;13(1):47-60. DOI:10.3920/BM2021.0107
94. Di Pierro F, Zanvit A, Nobili P, et al. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study. Clin Cosmet Investig Dent. 2015;7:107-13. DOI:10.2147/CCIDE.S93066.
95. Kisel'nikova LP, Tsarev VN, Toma EI, Podporin MS. Kliniko-mikrobiologicheskaia kharakteristika mikrobiotsenoza polosti rta detei i vozmozhnosti ego korrektsii s primeneniem probiotikov na osnove salivarnykh streptokokkov. Klinicheskaia stomatologiia. 2021;4:24-9 (in Russian). DOI:10.37988/1811-153X_2021_4_24
96. Tunçer S, Karaçam S. Cell-free supernatant of Streptococcus salivarius M18 impairs the pathogenic properties of Pseudomonas aeruginosa and Klebsiella pneumonia. Arch Microbiol. 2020;202(10):2825-40. DOI:10.1007/s00203-020-02005-8
97. Karaçam S, Tunçer S. Exploiting the Acidic Extracellular pH: Evaluation of Streptococcus salivarius M18 Postbiotics to Target Cancer Cells. Probiotics Antimicrob Proteins. 2021.
DOI:10.1007/s12602-021-09806-3
98. Burton JP, Drummond BK, Chilcott CN, et al. Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: a randomized double-blind, placebo-controlled trial. J Med Microbiol. 2013;62(Pt 6):875-84. DOI:10.1099/jmm.0.056663-0
99. Bardellini E, Amadori F, Gobbi E, et al. Does Streptococcus Salivarius Strain M18 Assumption Make Black Stains Disappear in Children? Oral Health Prev Dent. 2020;18(1):161-4. DOI:10.3290/j.ohpd.a43359
100. Gobbi E, De Francesco MA, Piccinelli G, et al. In vitro inhibitory effect of two commercial probiotics on chromogenic actinomycetes. Eur Arch Paediatr Dent. 2020;21(6):673-7. DOI:10.1007/s40368-020-00512-2
101. Gazhva SI, Belousova EYu. Features of the treatment of dental diseases in children with autism spectrum disorders against the background of dysbiosis. In the collection: Dental Spring in Belgorod – 2021. Proceedings of the International Scientific Conference of Young Scientists Working in the Field of Dentistry, dedicated to the year of science and technology. Belgorod, 2021; p. 36-7. Available: https://elibrary.ru/item.asp?id=48509394. Accessed: 26.05.2022 (in Russian).
102. Benic GZ, Farella M, Morgan XC, et al. Oral probiotics reduce halitosis in patients wearing orthodontic braces: a randomized, triple-blind, placebo-controlled trial. J Breath Res. 2019;13(3):036010. DOI:10.1088/1752-7163/ab1c81
103. Kravets ON, Deryabina LV. Clinical evaluation of the effectiveness of probiotics based on Streptococcus salivarius M18 in treatment of periodontal diseases. Problems of medical mycology. 2021;23(2):96. Available: https://elibrary.ru/item.asp?id=46212960. Accessed: 26.05.2022 (in Russian).
104. Manning J, Dunne EM, Wescombe PA, et al. Investigation of Streptococcus salivarius-mediated inhibition of pneumococcal adherence to pharyngeal epithelial cells. BMC Microbiol. 2016;16(1):225. DOI:10.1186/s12866-016-0843-z
105. Yoo HJ, Jwa SK, Kim DH, Ji YJ. Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro. Clin Exp Dent Res. 2020;6(2):207-14. DOI:10.1002/cre2.269
106. MacDonald KW, Chanyi RM, Macklaim JM, et al. Streptococcus salivarius inhibits immune activation by periodontal disease pathogens. BMC Oral Health. 2021;21(1):245. DOI:10.1186/s12903-021-01606-z
107. Poorni S, Nivedhitha MS, Srinivasan M, Balasubramaniam A. Effect of Probiotic Streptococcus salivarius K12 and M18 Lozenges on the Cariogram Parameters of Patients With High Caries Risk: A Randomised Control Trial. Cureus. 2022;14(3):e23282. DOI:10.7759/cureus.23282
108. Jansen PM, Abdelbary MMH, Conrads G. A concerted probiotic activity to inhibit periodontitis-associated bacteria. PLoS One. 2021;16(3):e0248308. DOI:10.1371/journal.pone.0248308
109. Borsche L, Glauner B, von Mendel J. COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis. Nutrients. 2021;13(10):3596. DOI:10.3390/nu13103596
110. Varikasuvu SR, Thangappazham B, Vykunta A, et al. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022;20(6):907-13. DOI:10.1080/14787210.2022.2035217
111. Cui X, Zhai Y, Wang S, et al. Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review and Meta-Analysis. Med Sci Monit. 2022;28:e935823. DOI:10.12659/MSM.935823
112. Youssef M, Ahmed HY, Zongo A, et al. Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases. Int J Mol Sci. 202;22(20):11290. DOI:10.3390/ijms222011290
113. Cunningham M, Azcarate-Peril MA, Barnard A, et al. Shaping the Future of Probiotics and Prebiotics. Trends Microbiol. 2021;29(8):667-85. DOI:10.1016/j.tim.2021.01.003
Авторы
Д.И. Трухан*, А.Ф. Сулимов, Л.Ю. Трухан
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*dmitry_trukhan@mail.ru
________________________________________________
Dmitry I. Trukhan*, Anatoly F. Sulimov, Larissa Yu. Trukhan