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Синдром раздраженного кишечника: актуальные аспекты этиологии, патогенеза, клиники и лечения
Синдром раздраженного кишечника: актуальные аспекты этиологии, патогенеза, клиники и лечения
Трухан Д.И., Голошубина В.В. Синдром раздраженного кишечника: актуальные аспекты этиологии, патогенеза, клиники и лечения. Consilium Medicum. 2022;24(5):297–305.
DOI: 10.26442/20751753.2022.5.201861
© ООО «КОНСИЛИУМ МЕДИКУМ», 2022 г.
DOI: 10.26442/20751753.2022.5.201861
© ООО «КОНСИЛИУМ МЕДИКУМ», 2022 г.
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Аннотация
Среди функциональных гастроинтестинальных расстройств синдром раздраженного кишечника (СРК) по праву продолжает сохранять ведущие позиции. СРК является своеобразным эталоном для понимания патогенетической сути функциональных заболеваний органов пищеварения, поскольку это наиболее распространенная, изученная и изучаемая патология. Так, по запросу «Irritable Bowel Syndrome» в электронной базе PubMed на 30.07.2022 найдено 16 599 источников, а по запросу «синдром раздраженного кишечника» в научной электронной библиотеке eLIBRARY.RU – 6316. В первой части обзора рассматриваются актуальные аспекты этиологии, патогенеза и клиники СРК. Актуальность проблемы СРК связана со значительным снижением качества жизни пациентов. В обзоре сделан акцент на роли психоэмоциональных расстройств, изменений, локализованных на уровне кишечной стенки, а также на роли COVID-19 в развитии СРК. Абдоминальная боль как ведущее проявление СРК связана в первую очередь со спазмом. В этом контексте спазмолитические препараты можно рассматривать не только как симптоматические, но и как средства патогенетической терапии СРК. Во второй части обзора подробно рассмотрены возможности одного из миотропных спазмолитиков в лечении СРК – мебеверина гидрохлорида.
Ключевые слова: синдром раздраженного кишечника, этиология, патогенез, качество жизни, психоэмоциональные расстройства, синдром повышенной эпителиальной проницаемости, клиника, абдоминальная боль, лечение, спазмолитики, мебеверин
Keywords: irritable bowel syndrome, etiology, pathogenesis, quality of life, psychoemotional disorders, increased epithelial permeability syndrome, clinic, abdominal pain, treatment, antispasmodics, mebeverine
Ключевые слова: синдром раздраженного кишечника, этиология, патогенез, качество жизни, психоэмоциональные расстройства, синдром повышенной эпителиальной проницаемости, клиника, абдоминальная боль, лечение, спазмолитики, мебеверин
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Keywords: irritable bowel syndrome, etiology, pathogenesis, quality of life, psychoemotional disorders, increased epithelial permeability syndrome, clinic, abdominal pain, treatment, antispasmodics, mebeverine
Полный текст
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Авторы
Д.И. Трухан*, В.В. Голошубина
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*dmitry_trukhan@mail.ru
Omsk State Medical University, Omsk, Russia
*dmitry_trukhan@mail.ru
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*dmitry_trukhan@mail.ru
________________________________________________
Omsk State Medical University, Omsk, Russia
*dmitry_trukhan@mail.ru
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