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Высокое нормальное давление – норма или фактор риска перинатальных осложнений: проспективное когортное исследование
Высокое нормальное давление – норма или фактор риска перинатальных осложнений: проспективное когортное исследование
Подзолкова Н.М., Скворцова М.Ю., Денисова Ю.В., Денисова Т.В. Высокое нормальное давление – норма или фактор риска перинатальных осложнений: проспективное когортное исследование. Consilium Medicum. 2022;24(7):466–472. DOI: 10.26442/20751753.2022.7.201785
© ООО «КОНСИЛИУМ МЕДИКУМ», 2022 г.
DOI: 10.26442/20751753.2022.7.201785
© ООО «КОНСИЛИУМ МЕДИКУМ», 2022 г.
________________________________________________
DOI: 10.26442/20751753.2022.7.201785
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Аннотация
Цель. Произвести сравнительную оценку влияния высокого нормального давления (ВНД) и артериальной гипертензии (АГ) 1–2-й степени на риск развития гестационных и перинатальных осложнений.
Материалы и методы. Проведено проспективное когортное исследование (n=110) влияния ВНД на риск развития гестационных осложнений и исходы беременности. В основную группу (n=70) вошли 30 пациенток с ВНД, составив подгруппу А, и 40 пациенток с АГ 1–2-й степени, составив подгруппу Б. В группу сравнения включены 40 пациенток с «гипертензией белого халата».
Результаты. Во II и III триместрах беременности наиболее частыми осложнениями оказались токсикоз, угроза прерывания, отеки, выявляемые более чем у 1/2 пациенток с ВНД, и АГ 1–2-й степени, а также угроза преждевременных родов (р<0,05). Частота развития преэклампсии в подгруппах А и Б значительно не отличалась, однако у пациенток с ВНД в III триместре при пробе эндотелийзависимой вазодилатации определялись признаки эндотелиальной дисфункции, что может быть одним из механизмов последующего формирования у этих пациенток АГ. Лишь в группах ВНД и АГ имела место плацентарная недостаточность различной степени выраженности. Плацентарная недостаточность наряду с внутриутробной гипоксией плода различной этиологии стали наиболее частными причинами выполнения экстренного кесарева сечения, встречавшегося лишь в основной группе, – 3 (75,0%) в подгруппе А и 6 (66,67%) в подгруппе Б – и ассоциировались с повышением артериального давления >130/85 мм рт. ст.
Заключение. Важность профилактики повышения артериального давления до высоких нормальных цифр объясняется развитием на поздних сроках беременности эндотелиальной дисфункции, что может оказаться одним из механизмов формирования АГ у данной категории беременных.
Ключевые слова: беременность, высокое нормальное давление, артериальная гипертензия, преэклампсия, сердечно-сосудистый риск
Materials and methods. A prospective cohort study (n=110) assessing the effect of high normotension on the risk of gestational complications and pregnancy outcomes was conducted. The main group (n=70) included 30 patients with high normotension – subgroup A, and 40 patients with hypertension 1–2nd stage – subgroup B. The comparison group included 40 patients with "white coat hypertension".
Results. The most frequent complications in the 2nd and 3rd trimesters of pregnancy were toxaemia, threatened miscarriage, edema (detected in more than half of patients with high normotension and hypertension 1–2nd stage) and well as threatened preterm labor (p<0.05). The frequency of pre-eclampsia development in subgroups A and B did not differ significantly, however, in patients with high normotension in the 3rd trimester during a test of endothelium-dependent vasodilation were detected signs of endothelial dysfunction, which may be one of the mechanisms for the subsequent formation of hypertension in these patients. Placental insufficiency of varying severity was detected only in subgroups A and B. Placental insufficiency, along with intrauterine fetal hypoxia of different etiologies, were the most frequent causes of emergency caesarean section, occurring only in the main group – 3 (75.0%) in subgroup A and 6 (66.67%) in subgroup B – and associated with blood pressure above 130/85 mm Hg.
Conclusion. The importance of preventing blood pressure increase to high normal rate is explained by the development of endothelial dysfunction at late gestation, which can serve as the mechanisms of hypertension formation in this category of pregnant women.
Keywords: pregnancy, high normotension, hypertension, preeclampsia, cardiovascular risk
Материалы и методы. Проведено проспективное когортное исследование (n=110) влияния ВНД на риск развития гестационных осложнений и исходы беременности. В основную группу (n=70) вошли 30 пациенток с ВНД, составив подгруппу А, и 40 пациенток с АГ 1–2-й степени, составив подгруппу Б. В группу сравнения включены 40 пациенток с «гипертензией белого халата».
Результаты. Во II и III триместрах беременности наиболее частыми осложнениями оказались токсикоз, угроза прерывания, отеки, выявляемые более чем у 1/2 пациенток с ВНД, и АГ 1–2-й степени, а также угроза преждевременных родов (р<0,05). Частота развития преэклампсии в подгруппах А и Б значительно не отличалась, однако у пациенток с ВНД в III триместре при пробе эндотелийзависимой вазодилатации определялись признаки эндотелиальной дисфункции, что может быть одним из механизмов последующего формирования у этих пациенток АГ. Лишь в группах ВНД и АГ имела место плацентарная недостаточность различной степени выраженности. Плацентарная недостаточность наряду с внутриутробной гипоксией плода различной этиологии стали наиболее частными причинами выполнения экстренного кесарева сечения, встречавшегося лишь в основной группе, – 3 (75,0%) в подгруппе А и 6 (66,67%) в подгруппе Б – и ассоциировались с повышением артериального давления >130/85 мм рт. ст.
Заключение. Важность профилактики повышения артериального давления до высоких нормальных цифр объясняется развитием на поздних сроках беременности эндотелиальной дисфункции, что может оказаться одним из механизмов формирования АГ у данной категории беременных.
Ключевые слова: беременность, высокое нормальное давление, артериальная гипертензия, преэклампсия, сердечно-сосудистый риск
________________________________________________
Materials and methods. A prospective cohort study (n=110) assessing the effect of high normotension on the risk of gestational complications and pregnancy outcomes was conducted. The main group (n=70) included 30 patients with high normotension – subgroup A, and 40 patients with hypertension 1–2nd stage – subgroup B. The comparison group included 40 patients with "white coat hypertension".
Results. The most frequent complications in the 2nd and 3rd trimesters of pregnancy were toxaemia, threatened miscarriage, edema (detected in more than half of patients with high normotension and hypertension 1–2nd stage) and well as threatened preterm labor (p<0.05). The frequency of pre-eclampsia development in subgroups A and B did not differ significantly, however, in patients with high normotension in the 3rd trimester during a test of endothelium-dependent vasodilation were detected signs of endothelial dysfunction, which may be one of the mechanisms for the subsequent formation of hypertension in these patients. Placental insufficiency of varying severity was detected only in subgroups A and B. Placental insufficiency, along with intrauterine fetal hypoxia of different etiologies, were the most frequent causes of emergency caesarean section, occurring only in the main group – 3 (75.0%) in subgroup A and 6 (66.67%) in subgroup B – and associated with blood pressure above 130/85 mm Hg.
Conclusion. The importance of preventing blood pressure increase to high normal rate is explained by the development of endothelial dysfunction at late gestation, which can serve as the mechanisms of hypertension formation in this category of pregnant women.
Keywords: pregnancy, high normotension, hypertension, preeclampsia, cardiovascular risk
Полный текст
Список литературы
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2. Mabuchi A, Yamamoto R, Ishii K, et al. Significance of high-normal blood pressure during early second trimester for predicting the onset of hypertensive disorders in pregnancy. Hypertens Pregnancy. 2016;35(2):234-41. DOI:10.3109/10641955.2016.1139719
3. The National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE guideline [NG136], 2019. Available at: www.nice.org.uk/guidance/ng136. Аccessed: 02.09.2022.
4. Hypertension in Pregnancy. Report of the American College of Obstetricians and Gynecologists’. Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122-31.
DOI:10.1097/01.AOG.0000437382.03963.88
5. Preeklampsiia. Eklampsiia. Oteki, proteinuriia i gipertenzivnye rasstroistva vo vremia beremennosti, v rodakh i poslerodovom periode. Klinicheskie rekomendatsii. Moscow, 2021. Available at: https://roag-portal.ru/recommendations_obstetrics. Accessed: 02.09.2022 (in Russian).
6. Kobalava ZD, Konradi AO, Nedogoda SV, et al. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020;25(3):3786 (in Russian). DOI:10.15829/1560-4071-2020-3-3786
7. Khalil A. Your essential revision guide: MRCOG part one: the official companion to the Royal College of Obstetricians and Gynecologists revision course. Chapter 31. Fiander A, Thilaganathan B, editors. London: Cambridge University Press, 2010.
8. Blackburn ST. Maternal, fetal, & neonatal physiology. A clinical perspective. Chapter 9. 4th ed. Philadelphia: Elsevier Saunders, 2013.
9. O’Donoghue K. Obstetrics by Ten Teachers. Chapter 3. 19th ed. Baker PN, Kenny LC, editors. London: CRC Press, 2011. DOI:10.1201/b13484
10. Duvekot JJ, Peeters LLH. Very early changes in cardiovascular physiology. Chamberlain G, Broughton-Pipkin F, editors. Clinical physiology in obstetrics. 3rd Ed. Malden, MA: Blackwell Science, 1998.
11. Wilson M, Morganti AA, Zervoudakis I, et al. Blood pressure, the renin-aldosterone system and sex steroids throughout normal pregnancy. Am J Med. 1980;68(1):97-104. DOI:10.1016/0002-9343(80)90178-3
12. Loerup L, Pullon RM, Birks J, et al. Trends of blood pressure and heart rate in normal pregnancies: a systematic review and meta-analysis. BMC Med. 2019;17(1):1-12. DOI:10.1186/s12916-019-1399-1
13. Wartolowska KA, Gerry S, Feakins BG, et al. A meta-analysis of temporal changes of response in the placebo arm of surgical randomized controlled trials: an update. Trials. 2017;18(1):323. DOI:10.1186/s13063-017-2070-9
14. Ishak KJ, Platt RW, Joseph L, et al. Meta-analysis of longitudinal studies. Clin Trials.2007;4(5):525-39. DOI:10.1177/1740774507083567
15. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Hypertens. 2017;71(6):1269-324. DOI:10.1161/HYP.0000000000000066
16. Rogoza AN, Agal'tsov MV, Sergeeva MV. Sutochnoe monitorirovanie arterial'nogo davleniia: varianty vrachebnykh zakliuchenii i kommentarii. Nizhny Novgorod: Saliut, 2005 (in Russian).
17. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction and adults at risk of atherosclerosis. Lancet. 2002;340:1111-5.
DOI:10.1016/0140-6736(92)93147-f
18. Konukoglu D, Uzun H. Endothelial Dysfunction and Hypertension. Adv Exp Med Biol. 2017;956:511-40. DOI:10.1007/5584_2016_90
19. Macdonald-Wallis C, Silverwood RJ, Fraser A, et al. Gestational-age-specific reference ranges for blood pressure in pregnancy: findings from a prospective cohort. J Hypertens. 2015;33(1):96-105. DOI:10.1097/HJH.0000000000000368
20. Lipatov IS, Tezikov YuV, Kutuzova OA, et al. Clinical and pathogenetic variants of maladaptation to pregnancy at early stages of gestation. Obstetrics, Gynecology and Reproduction. 2017;11(1):5-13 (in Russian). DOI:10.17749/2313-7347.2017.11.1.005-013
21. He D, Wu S, Zhao H, et al. High normal blood pressure in early pregnancy also contribute to early onset pre-eclampsia and severe pre-eclampsia. Clin Exp Hypertens. 2017;40(6):539-46. DOI:10.1080/10641963.2017.1407330
22. van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset pre-eclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30(23):2789-94. DOI:10.1080/14767058.2016.1263295
23. Sibai BM, Gordon T, Thom E, et al. Risk factors for pre-eclampsia in healthy nulliparous women: a prospective multicenter study. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstetrics Gynecol. 1995;172(2 Pt. 1):642-8. DOI:10.1016/0002-9378(95)90586-3
24. Ohkuchi A, Iwasaki R, Suzuki H, et al. Normal and high-normal blood pressures, but not body mass index, are risk factors for the subsequent occurrence of both pre-eclampsia and gestational hypertension: a retrospective cohort study. Hypertens Res. 2006;29(3):161-7. DOI:10.1291/hypres.29.161
25. Thadhani R, Stampfer MJ, Hunter DJ, et al. High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancy. Obstet Gynecol. 1999;94(4):543-50.
DOI:10.1016/s0029-7844(99)00400-7
26. O’Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of pre-eclampsia: a systematic overview. Epidemiology. 2003;14(3):368-74.
DOI:10.1097/00001648-200305000-00020
27. Bustamante Helfrich B, Chilukuri N, He H, et al. Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort. Placenta. 2017;52:106-13. DOI:10.1016/j.placenta.2017.02.016
28. Melchiorre K, Sutherland GR, Liberati M, Thilaganathan B. Maternal cardiovascular impairment in pregnancies complicated by severe fetal growth restriction. J Hypertens. 2012;60(2):437-43. DOI:10.1161/HYPERTENSIONAHA.112.194159
29. Cnossen JS, Vollebregt KC, de Vrieze N, et al. Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: systematic review and meta-analysis. BMJ. 2008;336(7653):1117-20. DOI:10.1136/bmj.39540.522049.BE
30. Rokоtyanskаya EA, Panova IA, Malyshkina AI, et al. Technologies for Prediction of Preeclampsia. Sovremennye tehnologii v medicine. 2020;12(5):78-86 (in Russian). DOI:10.17691/stm2020.12.5.09
31. North RA, McCowan LM, Dekker GA, et al. Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. BMJ. 2011;342:d1875. DOI:10.1136/bmj.d1875
32. LeFevre ML; U.S. Preventive Services Task Force. Low-dose aspirin use for the prevention of morbidity and mortality from pre-eclampsia: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;161(11):819-26. DOI:10.7326/M14-1884
33. Sun T, Xu М. Body weight and gestational outcomes in women with high normotension during pregnancy. Zhejiang Da XueXue Bao Yi Xue Ban. 2019;48(2):174-9. DOI:10.3785/j.issn.1008-9292.2019.04.08
34. Sutton EF, Hauspurg A, Caritis SN, et al. Maternal Outcomes Associated With Lower Range Stage 1 Hypertension. Obstet Gynecol. 2018;132(4):843-9. DOI:10.1097/AOG.0000000000002870
35. Bartsch E, Medcalf KE, Park AL, et al. High Risk of Pre-eclampsia Identification Group. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 2016;353:i1753. DOI:10.1136/bmj.i1753
36. Fox NS, Roman AS, Hastings J, et al. Blood pressure changes across gestation in patients with twin pregnancies. J Matern Fetal Neonatal Med. 2013;27(9):898-903. DOI:10.3109/14767058.2013.845660
37. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-104. DOI:10.1093/eurheartj/ehy339
2. Mabuchi A, Yamamoto R, Ishii K, et al. Significance of high-normal blood pressure during early second trimester for predicting the onset of hypertensive disorders in pregnancy. Hypertens Pregnancy. 2016;35(2):234-41. DOI:10.3109/10641955.2016.1139719
3. The National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE guideline [NG136], 2019. Available at: www.nice.org.uk/guidance/ng136. Аccessed: 02.09.2022.
4. Hypertension in Pregnancy. Report of the American College of Obstetricians and Gynecologists’. Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122-31.
DOI:10.1097/01.AOG.0000437382.03963.88
5. Преэклампсия. Эклампсия. Отеки, протеинурия и гипертензивные расстройства во время беременности, в родах и послеродовом периоде. Клинические рекомендации. М., 2021. Режим доступа: https://roag-portal.ru/recommendations_obstetrics. Ссылка активна на 02.09.2022 [Preeklampsiia. Eklampsiia. Oteki, proteinuriia i gipertenzivnye rasstroistva vo vremia beremennosti, v rodakh i poslerodovom periode. Klinicheskie rekomendatsii. Moscow, 2021. Available at: https://roag-portal.ru/recommendations_obstetrics. Accessed: 02.09.2022 (in Russian)].
6. Кобалава Ж.Д., Конради А.О., Недогода С.В., и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(3):3786 [Kobalava ZD, Konradi AO, Nedogoda SV, et al. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020;25(3):3786 (in Russian)]. DOI:10.15829/1560-4071-2020-3-3786
7. Khalil A. Your essential revision guide: MRCOG part one: the official companion to the Royal College of Obstetricians and Gynecologists revision course. Chapter 31. Fiander A, Thilaganathan B, editors. London: Cambridge University Press, 2010.
8. Blackburn ST. Maternal, fetal, & neonatal physiology. A clinical perspective. Chapter 9. 4th ed. Philadelphia: Elsevier Saunders, 2013.
9. O’Donoghue K. Obstetrics by Ten Teachers. Chapter 3. 19th ed. Baker PN, Kenny LC, editors. London: CRC Press, 2011. DOI:10.1201/b13484
10. Duvekot JJ, Peeters LLH. Very early changes in cardiovascular physiology. Chamberlain G, Broughton-Pipkin F, editors. Clinical physiology in obstetrics. 3rd Ed. Malden, MA: Blackwell Science, 1998.
11. Wilson M, Morganti AA, Zervoudakis I, et al. Blood pressure, the renin-aldosterone system and sex steroids throughout normal pregnancy. Am J Med. 1980;68(1):97-104. DOI:10.1016/0002-9343(80)90178-3
12. Loerup L, Pullon RM, Birks J, et al. Trends of blood pressure and heart rate in normal pregnancies: a systematic review and meta-analysis. BMC Med. 2019;17(1):1-12. DOI:10.1186/s12916-019-1399-1
13. Wartolowska KA, Gerry S, Feakins BG, et al. A meta-analysis of temporal changes of response in the placebo arm of surgical randomized controlled trials: an update. Trials. 2017;18(1):323. DOI:10.1186/s13063-017-2070-9
14. Ishak KJ, Platt RW, Joseph L, et al. Meta-analysis of longitudinal studies. Clin Trials.2007;4(5):525-39. DOI:10.1177/1740774507083567
15. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Hypertens. 2017;71(6):1269-324. DOI:10.1161/HYP.0000000000000066
16. Рогоза А.Н., Агальцов М.В., Сергеева М.В. Суточное мониторирование артериального давления: варианты врачебных заключений и комментарии. Н. Новгород: Салют, 2005 [Rogoza AN, Agal'tsov MV, Sergeeva MV. Sutochnoe monitorirovanie arterial'nogo davleniia: varianty vrachebnykh zakliuchenii i kommentarii. Nizhny Novgorod: Saliut, 2005 (in Russian)].
17. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction and adults at risk of atherosclerosis. Lancet. 2002;340:1111-5.
DOI:10.1016/0140-6736(92)93147-f
18. Konukoglu D, Uzun H. Endothelial Dysfunction and Hypertension. Adv Exp Med Biol. 2017;956:511-40. DOI:10.1007/5584_2016_90
19. Macdonald-Wallis C, Silverwood RJ, Fraser A, et al. Gestational-age-specific reference ranges for blood pressure in pregnancy: findings from a prospective cohort. J Hypertens. 2015;33(1):96-105. DOI:10.1097/HJH.0000000000000368
20. Липатов И.С., Тезиков Ю.В., Кутузова О.А., и др. Клинико-патогенетические варианты дезадаптации беременных на ранних сроках гестации. Акушерство, Гинекология и Репродукция. 2017;11(1):5-13 [Lipatov IS, Tezikov YuV, Kutuzova OA, et al. Clinical and pathogenetic variants of maladaptation to pregnancy at early stages of gestation. Obstetrics, Gynecology and Reproduction. 2017;11(1):5-13 (in Russian)]. DOI:10.17749/2313-7347.2017.11.1.005-013
21. He D, Wu S, Zhao H, et al. High normal blood pressure in early pregnancy also contribute to early onset pre-eclampsia and severe pre-eclampsia. Clin Exp Hypertens. 2017;40(6):539-46. DOI:10.1080/10641963.2017.1407330
22. van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset pre-eclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30(23):2789-94. DOI:10.1080/14767058.2016.1263295
23. Sibai BM, Gordon T, Thom E, et al. Risk factors for pre-eclampsia in healthy nulliparous women: a prospective multicenter study. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstetrics Gynecol. 1995;172(2 Pt. 1):642-8. DOI:10.1016/0002-9378(95)90586-3
24. Ohkuchi A, Iwasaki R, Suzuki H, et al. Normal and high-normal blood pressures, but not body mass index, are risk factors for the subsequent occurrence of both pre-eclampsia and gestational hypertension: a retrospective cohort study. Hypertens Res. 2006;29(3):161-7. DOI:10.1291/hypres.29.161
25. Thadhani R, Stampfer MJ, Hunter DJ, et al. High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancy. Obstet Gynecol. 1999;94(4):543-50.
DOI:10.1016/s0029-7844(99)00400-7
26. O’Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of pre-eclampsia: a systematic overview. Epidemiology. 2003;14(3):368-74.
DOI:10.1097/00001648-200305000-00020
27. Bustamante Helfrich B, Chilukuri N, He H, et al. Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort. Placenta. 2017;52:106-13. DOI:10.1016/j.placenta.2017.02.016
28. Melchiorre K, Sutherland GR, Liberati M, Thilaganathan B. Maternal cardiovascular impairment in pregnancies complicated by severe fetal growth restriction. J Hypertens. 2012;60(2):437-43. DOI:10.1161/HYPERTENSIONAHA.112.194159
29. Cnossen JS, Vollebregt KC, de Vrieze N, et al. Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: systematic review and meta-analysis. BMJ. 2008;336(7653):1117-20. DOI:10.1136/bmj.39540.522049.BE
30. Рокотянская Е.А., Панова И.А., Малышкина А.И., и др. Технологии прогнозирования преэклампсии. Современные технологии в медицине. 2020;12(5):78-86 [Rokоtyanskаya EA, Panova IA, Malyshkina AI, et al. Technologies for Prediction of Preeclampsia. Sovremennye tehnologii v medicine. 2020;12(5):78-86 (in Russian)]. DOI:10.17691/stm2020.12.5.09
31. North RA, McCowan LM, Dekker GA, et al. Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. BMJ. 2011;342:d1875. DOI:10.1136/bmj.d1875
32. LeFevre ML; U.S. Preventive Services Task Force. Low-dose aspirin use for the prevention of morbidity and mortality from pre-eclampsia: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;161(11):819-26. DOI:10.7326/M14-1884
33. Sun T, Xu М. Body weight and gestational outcomes in women with high normotension during pregnancy. Zhejiang Da XueXue Bao Yi Xue Ban. 2019;48(2):174-9. DOI:10.3785/j.issn.1008-9292.2019.04.08
34. Sutton EF, Hauspurg A, Caritis SN, et al. Maternal Outcomes Associated With Lower Range Stage 1 Hypertension. Obstet Gynecol. 2018;132(4):843-9. DOI:10.1097/AOG.0000000000002870
35. Bartsch E, Medcalf KE, Park AL, et al. High Risk of Pre-eclampsia Identification Group. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 2016;353:i1753. DOI:10.1136/bmj.i1753
36. Fox NS, Roman AS, Hastings J, et al. Blood pressure changes across gestation in patients with twin pregnancies. J Matern Fetal Neonatal Med. 2013;27(9):898-903. DOI:10.3109/14767058.2013.845660
37. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-104. DOI:10.1093/eurheartj/ehy339
________________________________________________
2. Mabuchi A, Yamamoto R, Ishii K, et al. Significance of high-normal blood pressure during early second trimester for predicting the onset of hypertensive disorders in pregnancy. Hypertens Pregnancy. 2016;35(2):234-41. DOI:10.3109/10641955.2016.1139719
3. The National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE guideline [NG136], 2019. Available at: www.nice.org.uk/guidance/ng136. Аccessed: 02.09.2022.
4. Hypertension in Pregnancy. Report of the American College of Obstetricians and Gynecologists’. Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122-31.
DOI:10.1097/01.AOG.0000437382.03963.88
5. Preeklampsiia. Eklampsiia. Oteki, proteinuriia i gipertenzivnye rasstroistva vo vremia beremennosti, v rodakh i poslerodovom periode. Klinicheskie rekomendatsii. Moscow, 2021. Available at: https://roag-portal.ru/recommendations_obstetrics. Accessed: 02.09.2022 (in Russian).
6. Kobalava ZD, Konradi AO, Nedogoda SV, et al. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020;25(3):3786 (in Russian). DOI:10.15829/1560-4071-2020-3-3786
7. Khalil A. Your essential revision guide: MRCOG part one: the official companion to the Royal College of Obstetricians and Gynecologists revision course. Chapter 31. Fiander A, Thilaganathan B, editors. London: Cambridge University Press, 2010.
8. Blackburn ST. Maternal, fetal, & neonatal physiology. A clinical perspective. Chapter 9. 4th ed. Philadelphia: Elsevier Saunders, 2013.
9. O’Donoghue K. Obstetrics by Ten Teachers. Chapter 3. 19th ed. Baker PN, Kenny LC, editors. London: CRC Press, 2011. DOI:10.1201/b13484
10. Duvekot JJ, Peeters LLH. Very early changes in cardiovascular physiology. Chamberlain G, Broughton-Pipkin F, editors. Clinical physiology in obstetrics. 3rd Ed. Malden, MA: Blackwell Science, 1998.
11. Wilson M, Morganti AA, Zervoudakis I, et al. Blood pressure, the renin-aldosterone system and sex steroids throughout normal pregnancy. Am J Med. 1980;68(1):97-104. DOI:10.1016/0002-9343(80)90178-3
12. Loerup L, Pullon RM, Birks J, et al. Trends of blood pressure and heart rate in normal pregnancies: a systematic review and meta-analysis. BMC Med. 2019;17(1):1-12. DOI:10.1186/s12916-019-1399-1
13. Wartolowska KA, Gerry S, Feakins BG, et al. A meta-analysis of temporal changes of response in the placebo arm of surgical randomized controlled trials: an update. Trials. 2017;18(1):323. DOI:10.1186/s13063-017-2070-9
14. Ishak KJ, Platt RW, Joseph L, et al. Meta-analysis of longitudinal studies. Clin Trials.2007;4(5):525-39. DOI:10.1177/1740774507083567
15. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Hypertens. 2017;71(6):1269-324. DOI:10.1161/HYP.0000000000000066
16. Rogoza AN, Agal'tsov MV, Sergeeva MV. Sutochnoe monitorirovanie arterial'nogo davleniia: varianty vrachebnykh zakliuchenii i kommentarii. Nizhny Novgorod: Saliut, 2005 (in Russian).
17. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction and adults at risk of atherosclerosis. Lancet. 2002;340:1111-5.
DOI:10.1016/0140-6736(92)93147-f
18. Konukoglu D, Uzun H. Endothelial Dysfunction and Hypertension. Adv Exp Med Biol. 2017;956:511-40. DOI:10.1007/5584_2016_90
19. Macdonald-Wallis C, Silverwood RJ, Fraser A, et al. Gestational-age-specific reference ranges for blood pressure in pregnancy: findings from a prospective cohort. J Hypertens. 2015;33(1):96-105. DOI:10.1097/HJH.0000000000000368
20. Lipatov IS, Tezikov YuV, Kutuzova OA, et al. Clinical and pathogenetic variants of maladaptation to pregnancy at early stages of gestation. Obstetrics, Gynecology and Reproduction. 2017;11(1):5-13 (in Russian). DOI:10.17749/2313-7347.2017.11.1.005-013
21. He D, Wu S, Zhao H, et al. High normal blood pressure in early pregnancy also contribute to early onset pre-eclampsia and severe pre-eclampsia. Clin Exp Hypertens. 2017;40(6):539-46. DOI:10.1080/10641963.2017.1407330
22. van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset pre-eclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30(23):2789-94. DOI:10.1080/14767058.2016.1263295
23. Sibai BM, Gordon T, Thom E, et al. Risk factors for pre-eclampsia in healthy nulliparous women: a prospective multicenter study. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstetrics Gynecol. 1995;172(2 Pt. 1):642-8. DOI:10.1016/0002-9378(95)90586-3
24. Ohkuchi A, Iwasaki R, Suzuki H, et al. Normal and high-normal blood pressures, but not body mass index, are risk factors for the subsequent occurrence of both pre-eclampsia and gestational hypertension: a retrospective cohort study. Hypertens Res. 2006;29(3):161-7. DOI:10.1291/hypres.29.161
25. Thadhani R, Stampfer MJ, Hunter DJ, et al. High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancy. Obstet Gynecol. 1999;94(4):543-50.
DOI:10.1016/s0029-7844(99)00400-7
26. O’Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of pre-eclampsia: a systematic overview. Epidemiology. 2003;14(3):368-74.
DOI:10.1097/00001648-200305000-00020
27. Bustamante Helfrich B, Chilukuri N, He H, et al. Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort. Placenta. 2017;52:106-13. DOI:10.1016/j.placenta.2017.02.016
28. Melchiorre K, Sutherland GR, Liberati M, Thilaganathan B. Maternal cardiovascular impairment in pregnancies complicated by severe fetal growth restriction. J Hypertens. 2012;60(2):437-43. DOI:10.1161/HYPERTENSIONAHA.112.194159
29. Cnossen JS, Vollebregt KC, de Vrieze N, et al. Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: systematic review and meta-analysis. BMJ. 2008;336(7653):1117-20. DOI:10.1136/bmj.39540.522049.BE
30. Rokоtyanskаya EA, Panova IA, Malyshkina AI, et al. Technologies for Prediction of Preeclampsia. Sovremennye tehnologii v medicine. 2020;12(5):78-86 (in Russian). DOI:10.17691/stm2020.12.5.09
31. North RA, McCowan LM, Dekker GA, et al. Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. BMJ. 2011;342:d1875. DOI:10.1136/bmj.d1875
32. LeFevre ML; U.S. Preventive Services Task Force. Low-dose aspirin use for the prevention of morbidity and mortality from pre-eclampsia: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;161(11):819-26. DOI:10.7326/M14-1884
33. Sun T, Xu М. Body weight and gestational outcomes in women with high normotension during pregnancy. Zhejiang Da XueXue Bao Yi Xue Ban. 2019;48(2):174-9. DOI:10.3785/j.issn.1008-9292.2019.04.08
34. Sutton EF, Hauspurg A, Caritis SN, et al. Maternal Outcomes Associated With Lower Range Stage 1 Hypertension. Obstet Gynecol. 2018;132(4):843-9. DOI:10.1097/AOG.0000000000002870
35. Bartsch E, Medcalf KE, Park AL, et al. High Risk of Pre-eclampsia Identification Group. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 2016;353:i1753. DOI:10.1136/bmj.i1753
36. Fox NS, Roman AS, Hastings J, et al. Blood pressure changes across gestation in patients with twin pregnancies. J Matern Fetal Neonatal Med. 2013;27(9):898-903. DOI:10.3109/14767058.2013.845660
37. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-104. DOI:10.1093/eurheartj/ehy339
Авторы
Н.М. Подзолкова, М.Ю. Скворцова, Ю.В. Денисова*, Т.В. Денисова
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*yuliya.sheveleva.97@mail.ru
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*yuliya.sheveleva.97@mail.ru
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*yuliya.sheveleva.97@mail.ru
________________________________________________
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*yuliya.sheveleva.97@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.