Выбор патогенетической терапии для пациента с дорсалгией

1. de Luca K, Tavares P, Yang H, et al. Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey. Int J Environ Res Public Health. 2023;20(7):5369. DOI:10.3390/ijerph20075369
2. Zemedikun D, Kigozi J, Wynne-Jones G, et al. Methodological considerations in the assessment of direct and indirect costs of back pain: A systematic scoping review. PLoS One. 2021;16(5):e0251406. DOI:10.1371/journal.pone.0251406
3. Long H, Liu Q, Yin H, et al. Prevalence Trends of Site-Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019. Arthritis Rheumatol. 2022;74(7):1172-83. DOI:10.1002/art.42089 
4. Suri P, Hunter DJ, Rainville J, et al. Presence and extent of severe facet joint osteoarthritis are associated with back pain in older adults. Osteoart Cartil. 2013;21(9):1199-206. DOI:10.1016/j.joca.2013.05.013
5. Ko S, Vaccaro AR, Lee S, et al. The prevalence of lumbar spine facet joint osteoarthritis and its association with low back pain in selected Korean populations. Clin Orthop Surg. 2014;6(4):385-91. DOI:10.4055/cios.2014.6.4.385
6. Du R, Xu G, Bai X, Li Z. Facet Joint Syndrome: Pathophysiology, Diagnosis, and Treatment. J Pain Res. 2022:15:3689-710. DOI:10.2147/JPR.S389602
7. Calvo E, Palacios I, Delgado E, et al. Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis. Osteoarthritis Cartilage. 2004;12(11):878-86. DOI:10.1016/j.joca.2004.07.007
8. Perolat R, Kastler A, Nicot B, et al. Facet joint syndrome: from diagnosis to interventional management. Insights Imaging. 2018;9(5):773-89. DOI:10.1007/s13244-018-0638-x
9. Russo VM, Dhawan RT, Baudracco I, et al. Hybrid bone SPECT/CT imaging in evaluation of chronic low back pain: correlation with facet joint arthropathy. World Neurosurg. 2017;107:732-8. DOI:10.1016/j.wneu.2017.08.092 
10. Giles LG, Taylor JR. Human zygapophyseal joint capsule and synovial fold innervation. Br J Rheumatol. 1987;26(2):93-8. DOI:10.1093/ rheumatology/26.2.93
11. Kim JS, Ali MH, Wydra F, et al. Characterization of degenerative human facet joints and facet joint capsular tissues. Osteoart Cartil. 2015;23(12):2242-51. DOI:10.1016/j.joca.2015.06.009
12. Sakuma Y, Ohtori S, Miyagi M, et al. Up-regulation of p55 TNF alpha-receptor in dorsal root ganglia neurons following lumbar facet joint injury in rats. Eur Spine J. 2007;16(8):1273-8. DOI:10.1007/s00586-007-0365-3
13. Gómez Vega JC, Acevedo-González JC. Clinical diagnosis scale for pain lumbar of facet origin: systematic review of literature and pilot study. Neurocirugia. 2019;30(3):133-43. DOI:10.1016/j.neucir.2018.05.004
14. Bai R, Li Y, Zhang F. Osteopontin, a bridge links osteoarthritis and osteoporosis. Front Endocrinol (Lausanne). 2022;13:1012508. DOI:10.3389/fendo.2022.1012508
15. Dedrick D, Goldstein S, Brandt K, et al. A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheumatol. 1993;36(10):1460-7. DOI:10.1002/art.1780361019
16. Никитин А.С. Синдром оперированного позвоночника. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(5):112-8 [Nikitin AS. Failed back surgery syndrome. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2016;116(5):112-8 (in Russian)]. DOI:10.17116/jnevro201611651112-118
17. Баранцевич Е.Р., Зевахин С.В., Рачин С.А. Синдром оперированного позвоночника: современное состояние проблемы. Междисциплинарная неврология. 2018;1:38-44 [Barantsevich ER, Zevakhin SV, Rachin SA. Operated spine syndrome: the current state of the problem. Interdisciplinary Neurology. 2018;1:38-44 (in Russian)].
18. Djuric N, Lafeber GCM, Li W, et al. Exploring macrophage differentiation and its relation to Modic changes in human herniated disc tissue. Brain Spine. 2022;2:101698. DOI:10.1016/j.bas.2022.101698
19. Cunha C, Silva AJ, Pereira P, et al. The inflammatory response in the regression of lumbar disc herniation. Arthritis Res Ther. 2018;20(1):251. DOI:10.1186/s13075-018-1743-4
20. Woods BI, Hilibrand AS. Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment. J Spinal Disord Tech. 2015;28(5):E251-9.
21. Новикова А.В., Правдюк Н.Г., Саклакова В.С., и др. Дегенеративная болезнь диска у молодых: цитокиновый профиль и факторы ангиогенеза. Вестник РГМУ. 2021;6:80-7 [Novikova AV, Pravdyuk NG, Saklakova VS, et al. Degenerative disc disease in young people: cytokine profile and angiogenesis factors. Bulletin of the RSMU. 2021;6:80-7 (in Russian)]. DOI:10.24075/brsmu.2021.061
22. Тян А.А., Чурюканов М.В., Медведева Л.А., Загорулько О.И. Немедикаментозные методы лечения неспецифической боли в спине. Современное состояние проблемы. Российский журнал боли. 2019;18(2):5-13 [Tyan AA, Churyukanov MV, Medvedeva LA, Zagorulko OI. Non-medicamental methods for treatment of non-specific low back pain. Present condition of the problem. Russian Journal of Pain. 2019;18(2):5-13 (in Russian)]. DOI:10.25731/RASP.2019.02.14
23. Sabrina S, Farooqui S, Khan MA, et al. Effectiveness of Evidence Based Physical Therapy Management Approaches in Sacroiliac Joint Dysfunction: A Meta-analysis. J Coll Physicians Surg Pak. 2023;33(5):572-7. DOI:10.29271/jcpsp.2023.05.572
24. Барулин А.Е., Курушина О.В., Пучков А.Е. Комплексное лечение острой неспецифической боли в нижней части спины. Неврология, нейропсихиатрия, психосоматика. 2014;6(3):38-42 [Barulin AE, Kurushina OV, Puchkov AE. Combination treatment for acute non-specific low back pain. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(3):38-42 (in Russian)]. DOI:10.14412/2074-2711-2014-3-38-42
25. Парфенов В.А., Парфенова Е.В. Персонализированный подход к ведению пациентов с хронической неспецифической болью в спине. Медицинский совет.
2022;(11):48-53 [Parfenov VA, Parfenova EV. A personalized approach to the management of patients with chronic nonspecific back pain. Meditsinskiy sovet = Medical Council.
2022;(11):48-53 (in Russian)]. DOI:10.21518/2079-701X-2022-16-11-48-53
26. Каратеев А.Е., Лила А.М., Дыдыкина И.С., и др. Персонификация применения нестероидных противовоспалительных препаратов при скелетномышечных заболеваниях. Резолюция по результатам совещания экспертов от 13 декабря 2017 года. Медицинский совет. 2018;(18):76-84 [Karateev AE, Lila AM, Dydykina IS, et al. Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017. Meditsinskiy sovet = Medical Council. 2018;(18):76-84 (in Russian)]. DOI:10.21518/2079-701X-2018-18-76-84
27. Камчатнов П.Р. Повышение эффективности и безопасности лечения пациентов с поясничной болью. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(10):28-33 [Kamchatnov PR. Improving the efficiency and safety of treatment of patients with lumbar pain. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2016;116(10):28-33 (in Russian)]. DOI:10.17116/jnevro201611610128-33 
28. Камчатнов П.Р., Чугунов А.В., Ашалмагомедова З.А., Шемшединова А.М. Проблемы безопасности лечения пациентов с дорсалгией. РМЖ. 2021;29(6):48-52 [Kamchatnov PR, Chugunov AV, Ashalmagomedova ZA, Shemshedinova AM. Problems of safety in the treatment of patients with dorsalgia. RMZh. 2021;29(6):48-52 (in Russian)].
29. Yang Z, Mathieson S, Kobayashi S, et al. Prevalence of non-steroidal anti-inflammatory drugs prescribed osteoarthritis: systematic review and meta-analysis of observational studies. Arthritis Care Res (Hoboken). 2023;75(11):2345-58. DOI:10.1002/acr.25157 
30. Caiazzo E, Ialenti A, Cicala C. The relatively selective cyclooxygenase-2 inhibitor nimesulide: What's going on? Eur J Pharmacol. 2019;848:10511. DOI:10.1016/j.ejphar.2019.01.044. 
31. Pohjolainen T, Jekunen A, Autio L, Vuorela H. Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen. Spine. 2000;25(12):1579-85. 
32. Шихкеримов Р.К. Применение нимесулида у пациентов с поясничной болью. Журнал неврологи и психиатрии им. С.С. Корсакова. 2016;116(5):28-32 [Shikhkerimov RK. The use of nimesulide in patients with lumbar pain. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2016;116(5):28-32 (in Russian)].
33. Камчатнов П.Р., Казаков А.Ю., Чугунов А.В. Эффективность и безопасность применения нимесулида для лечения пациентов с дорсопатией. Consilium Medicum. 2016;18(9):116-21 [Kamchatnov PR, Kazakov AYu, Chugunov AV. Efficacy and safety of nimesulide for the treatment of patients with dorsopathy. Consilium Medicum. 2016;18(9):116-21 (in Russian)].
34. Roberto G, Bartolini C, Rea F, et al. Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE). NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease. Eur J Clin Pharmacol. 2018;74(5):637-43. DOI:10.1007/s00228-018-2411-y
35. Zhou L, Pang X, Jiang J, et al. Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. Drug Metab Dispos. 2017;45(5):441-8. DOI:10.1124/dmd.116.074104
36. Kwon J, Kim S, Yoo H, Lee E. Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis. PLoS One. 2019;14(1):e0209264. DOI:10.1371/journal.pone.0209264
37. Low EXS, Zheng Q, Chan E, Lim SG. Drug induced liver injury: East versus West – a systematic review and meta-analysis. Clin Mol Hepatol. 2020;26(2):142-54. DOI:10.3350/cmh.2019.1003
38. Venegoni M, Da Cas R, Menniti-Ippolito F, Traversa G. Effects of the European restrictive actions concerning nimesulide prescription: a simulation study on hepatopathies and gastrointestinal bleedings in Italy. Ann Ist Super Sanita. 2010;46(2):153-7. DOI:0.4415/ANN_10_02_08
39. Süleyman H, Demircan B, Karagöz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep. 2007;59(3):247-58.
40. Koizumi S, Odashima M, Otaka M, et al. Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. J Gastroenterol. 2009;44:419-25. DOI:10.1007/s00535-009-0028-8
41. Zak MY, Klymenko MO, Iakovenko NO, Grischenko GV. Medico-social value of osteoarthritis. Secondary prevention and treatment of osteoarthritis in comorbidity with chronic gastritis. Wiad Lek. 2019;72(5 cz 2):1064-7. 
42. Castellsague J, Riera-Guardia N, Calingaert B, et al. Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012;35(12):1127-46. DOI:10.2165/11633470-000000000-00000
43. Алексеева Л.И., Каратеев А.Е., Попкова Т.В., и др. Эффективность и безопасность длительного применения нимесулида у больных остеоартрозом: результаты 12-месячного открытого контролируемого исследования ДИНАМО (Длительное Использование Нимесулида при Артрозе Многофакторная Оценка). Научно-практическая ревматология. 2009;4:64-72 [Alekseeva LI, Karateev AE, Popkova TV, et al. Efficacy and safety of long-term use of nimesulide in patients with osteoarthritis: results of a 12-month open controlled study of DYNAMO (Long-term Use of nimesulide in Arthrosis Multifactorial Assessment). Rheumatology Science and Practice. 2009;4:64-72 (in Russian)].
44. Fanelli A, Ghisi D, Aprile PL, Lapi F. Cardiovascular and cerebrovascular risk with nonsteroidal anti-inflammatory drugs and cyclooxygenase 2 inhibitors: latest evidence and clinical implications. Ther Adv Drug Saf. 2017;8:173-82. DOI:10.1177/2042098617690485
45. Masclee GMC, Straatman H, Arfè A, et al. Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project. PLoS One. 2018;13(11):e0204746. DOI:10.1371/journal.pone.0204746
46. Schink T, Kollhorst B, Varas Lorenzo C, et al. Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project. PLoS One. 2018;13(9):e0203362. DOI:10.1371/journal.pone.0203362
47. Mason L, Moore A, Edwards J, Derry S. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet Disord. 2004;5:28. DOI:10.1186/1471-2474-5-28

________________________________________________

1. de Luca K, Tavares P, Yang H, et al. Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey. Int J Environ Res Public Health. 2023;20(7):5369. DOI:10.3390/ijerph20075369
2. Zemedikun D, Kigozi J, Wynne-Jones G, et al. Methodological considerations in the assessment of direct and indirect costs of back pain: A systematic scoping review. PLoS One. 2021;16(5):e0251406. DOI:10.1371/journal.pone.0251406
3. Long H, Liu Q, Yin H, et al. Prevalence Trends of Site-Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019. Arthritis Rheumatol. 2022;74(7):1172-83. DOI:10.1002/art.42089 
4. Suri P, Hunter DJ, Rainville J, et al. Presence and extent of severe facet joint osteoarthritis are associated with back pain in older adults. Osteoart Cartil. 2013;21(9):1199-206. DOI:10.1016/j.joca.2013.05.013
5. Ko S, Vaccaro AR, Lee S, et al. The prevalence of lumbar spine facet joint osteoarthritis and its association with low back pain in selected Korean populations. Clin Orthop Surg. 2014;6(4):385-91. DOI:10.4055/cios.2014.6.4.385
6. Du R, Xu G, Bai X, Li Z. Facet Joint Syndrome: Pathophysiology, Diagnosis, and Treatment. J Pain Res. 2022:15:3689-710. DOI:10.2147/JPR.S389602
7. Calvo E, Palacios I, Delgado E, et al. Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis. Osteoarthritis Cartilage. 2004;12(11):878-86. DOI:10.1016/j.joca.2004.07.007
8. Perolat R, Kastler A, Nicot B, et al. Facet joint syndrome: from diagnosis to interventional management. Insights Imaging. 2018;9(5):773-89. DOI:10.1007/s13244-018-0638-x
9. Russo VM, Dhawan RT, Baudracco I, et al. Hybrid bone SPECT/CT imaging in evaluation of chronic low back pain: correlation with facet joint arthropathy. World Neurosurg. 2017;107:732-8. DOI:10.1016/j.wneu.2017.08.092 
10. Giles LG, Taylor JR. Human zygapophyseal joint capsule and synovial fold innervation. Br J Rheumatol. 1987;26(2):93-8. DOI:10.1093/ rheumatology/26.2.93
11. Kim JS, Ali MH, Wydra F, et al. Characterization of degenerative human facet joints and facet joint capsular tissues. Osteoart Cartil. 2015;23(12):2242-51. DOI:10.1016/j.joca.2015.06.009
12. Sakuma Y, Ohtori S, Miyagi M, et al. Up-regulation of p55 TNF alpha-receptor in dorsal root ganglia neurons following lumbar facet joint injury in rats. Eur Spine J. 2007;16(8):1273-8. DOI:10.1007/s00586-007-0365-3
13. Gómez Vega JC, Acevedo-González JC. Clinical diagnosis scale for pain lumbar of facet origin: systematic review of literature and pilot study. Neurocirugia. 2019;30(3):133-43. DOI:10.1016/j.neucir.2018.05.004
14. Bai R, Li Y, Zhang F. Osteopontin, a bridge links osteoarthritis and osteoporosis. Front Endocrinol (Lausanne). 2022;13:1012508. DOI:10.3389/fendo.2022.1012508
15. Dedrick D, Goldstein S, Brandt K, et al. A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheumatol. 1993;36(10):1460-7. DOI:10.1002/art.1780361019
16. Nikitin AS. Failed back surgery syndrome. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2016;116(5):112-8 (in Russian). DOI:10.17116/jnevro201611651112-118
17. Barantsevich ER, Zevakhin SV, Rachin SA. Operated spine syndrome: the current state of the problem. Interdisciplinary Neurology. 2018;1:38-44 (in Russian).
18. Djuric N, Lafeber GCM, Li W, et al. Exploring macrophage differentiation and its relation to Modic changes in human herniated disc tissue. Brain Spine. 2022;2:101698. DOI:10.1016/j.bas.2022.101698
19. Cunha C, Silva AJ, Pereira P, et al. The inflammatory response in the regression of lumbar disc herniation. Arthritis Res Ther. 2018;20(1):251. DOI:10.1186/s13075-018-1743-4
20. Woods BI, Hilibrand AS. Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment. J Spinal Disord Tech. 2015;28(5):E251-9.
21. Novikova AV, Pravdyuk NG, Saklakova VS, et al. Degenerative disc disease in young people: cytokine profile and angiogenesis factors. Bulletin of the RSMU. 2021;6:80-7 (in Russian). DOI:10.24075/brsmu.2021.061
22. Tyan AA, Churyukanov MV, Medvedeva LA, Zagorulko OI. Non-medicamental methods for treatment of non-specific low back pain. Present condition of the problem. Russian Journal of Pain. 2019;18(2):5-13 (in Russian). DOI:10.25731/RASP.2019.02.14
23. Sabrina S, Farooqui S, Khan MA, et al. Effectiveness of Evidence Based Physical Therapy Management Approaches in Sacroiliac Joint Dysfunction: A Meta-analysis. J Coll Physicians Surg Pak. 2023;33(5):572-7. DOI:10.29271/jcpsp.2023.05.572
24. Barulin AE, Kurushina OV, Puchkov AE. Combination treatment for acute non-specific low back pain. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(3):38-42 (in Russian). DOI:10.14412/2074-2711-2014-3-38-42
25. Parfenov VA, Parfenova EV. A personalized approach to the management of patients with chronic nonspecific back pain. Meditsinskiy sovet = Medical Council. 2022;(11):48-53 (in Russian). DOI:10.21518/2079-701X-2022-16-11-48-53
26. Karateev AE, Lila AM, Dydykina IS, et al. Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017. Meditsinskiy sovet = Medical Council. 2018;(18):76-84 (in Russian). DOI:10.21518/2079-701X-2018-18-76-84
27. Kamchatnov PR. Improving the efficiency and safety of treatment of patients with lumbar pain. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2016;116(10):28-33 (in Russian). DOI:10.17116/jnevro201611610128-33 
28. Kamchatnov PR, Chugunov AV, Ashalmagomedova ZA, Shemshedinova AM. Problems of safety in the treatment of patients with dorsalgia. RMZh. 2021;29(6):48-52 (in Russian).
29. Yang Z, Mathieson S, Kobayashi S, et al. Prevalence of non-steroidal anti-inflammatory drugs prescribed osteoarthritis: systematic review and meta-analysis of observational studies. Arthritis Care Res (Hoboken). 2023;75(11):2345-58. DOI:10.1002/acr.25157 
30. Caiazzo E, Ialenti A, Cicala C. The relatively selective cyclooxygenase-2 inhibitor nimesulide: What's going on? Eur J Pharmacol. 2019;848:10511. DOI:10.1016/j.ejphar.2019.01.044. 
31. Pohjolainen T, Jekunen A, Autio L, Vuorela H. Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen. Spine. 2000;25(12):1579-85. 
32. Shikhkerimov RK. The use of nimesulide in patients with lumbar pain. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2016;116(5):28-32 (in Russian).
33. Kamchatnov PR, Kazakov AYu, Chugunov AV. Efficacy and safety of nimesulide for the treatment of patients with dorsopathy. Consilium Medicum. 2016;18(9):116-21 (in Russian).
34. Roberto G, Bartolini C, Rea F, et al. Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE). NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease. Eur J Clin Pharmacol. 2018;74(5):637-43. DOI:10.1007/s00228-018-2411-y
35. Zhou L, Pang X, Jiang J, et al. Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. Drug Metab Dispos. 2017;45(5):441-8. DOI:10.1124/dmd.116.074104
36. Kwon J, Kim S, Yoo H, Lee E. Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis. PLoS One. 2019;14(1):e0209264. DOI:10.1371/journal.pone.0209264
37. Low EXS, Zheng Q, Chan E, Lim SG. Drug induced liver injury: East versus West – a systematic review and meta-analysis. Clin Mol Hepatol. 2020;26(2):142-54. DOI:10.3350/cmh.2019.1003
38. Venegoni M, Da Cas R, Menniti-Ippolito F, Traversa G. Effects of the European restrictive actions concerning nimesulide prescription: a simulation study on hepatopathies and gastrointestinal bleedings in Italy. Ann Ist Super Sanita. 2010;46(2):153-7. DOI:0.4415/ANN_10_02_08
39. Süleyman H, Demircan B, Karagöz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep. 2007;59(3):247-58.
40. Koizumi S, Odashima M, Otaka M, et al. Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. J Gastroenterol. 2009;44:419-25. DOI:10.1007/s00535-009-0028-8
41. Zak MY, Klymenko MO, Iakovenko NO, Grischenko GV. Medico-social value of osteoarthritis. Secondary prevention and treatment of osteoarthritis in comorbidity with chronic gastritis. Wiad Lek. 2019;72(5 cz 2):1064-7. 
42. Castellsague J, Riera-Guardia N, Calingaert B, et al. Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012;35(12):1127-46. DOI:10.2165/11633470-000000000-00000
43. Alekseeva LI, Karateev AE, Popkova TV, et al. Efficacy and safety of long-term use of nimesulide in patients with osteoarthritis: results of a 12-month open controlled study of DYNAMO (Long-term Use of nimesulide in Arthrosis Multifactorial Assessment). Rheumatology Science and Practice. 2009;4:64-72 (in Russian).
44. Fanelli A, Ghisi D, Aprile PL, Lapi F. Cardiovascular and cerebrovascular risk with nonsteroidal anti-inflammatory drugs and cyclooxygenase 2 inhibitors: latest evidence and clinical implications. Ther Adv Drug Saf. 2017;8:173-82. DOI:10.1177/2042098617690485
45. Masclee GMC, Straatman H, Arfè A, et al. Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project. PLoS One. 2018;13(11):e0204746. DOI:10.1371/journal.pone.0204746
46. Schink T, Kollhorst B, Varas Lorenzo C, et al. Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project. PLoS One. 2018;13(9):e0203362. DOI:10.1371/journal.pone.0203362
47. Mason L, Moore A, Edwards J, Derry S. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet Disord. 2004;5:28. DOI:10.1186/1471-2474-5-28

П.Р. Камчатнов*^1,2, Р.А. Черемин³, Л.А. Скипетрова³, А.В. Чугунов¹, С.В. Приказчиков<sup>4

1</sup>ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
²ГБУЗ «Городская клиническая больница им. В.М. Буянова» Департамента здравоохранения г. Москвы, Москва, Россия;
³ГБУЗ «Центр патологии речи и нейрореабилитации» Департамента здравоохранения г. Москвы, Москва, Россия;
⁴ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента» Департамента здравоохранения г. Москвы, Москва, Россия
*pavkam7@gmail.com

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Pavel R. Kamchatnov*^1,2, Roman A. Cheremin³, Liudmila A. Skipetrova³, Alexandr V. Chugunov¹, Sergei V. Prikazchikov<sup>4

1</sup>Pirogov Russian National Research Medical University, Moscow, Russia;
²Buyanov City Clinical Hospital, Moscow, Russia;
³Center for the Dissemination of Speech and Neurorehabilitation, Moscow, Russia;
⁴Scientific Research Institute of Health and Medical Management, Moscow, Russia
*pavkam7@gmail.com