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        • №5 Гастроэнтерология
        • Неалкогольная жировая болезнь печени: от понимания факторов риска к поиску оптимальных схем терапии

        Неалкогольная жировая болезнь печени: от понимания факторов риска к поиску оптимальных схем терапии

        Теплюк Д.А., Кайсина А.А., Ибрагимова Ш.И., Беставашвили А.А., Тинькова И.О., Пашкова Е.Ю., Кайбуллаева Д.А., Нерсесов А.В., Павлов Ч.С. Неалкогольная жировая болезнь печени: от понимания факторов риска к поиску оптимальных схем терапии. Consilium Medicum. 2023;25(5):325–332.
        DOI: 10.26442/20751753.2023.5.202272

        © ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.

        ________________________________________________

        Teplyuk DA, Kaisina AA, Ibragimova ShI, Bestavashvili AA, Tinkova IO, Pashkova EIu, Kaibullayeva JA, Nersesov AV, Pavlov ChS. Non-alcoholic fatty liver disease: from understanding risk factors to finding optimal treatment regimens: A review. Consilium Medicum. 2023;25(5): 325–332 . DOI: 10.26442/20751753.2023.5.202272

        Неалкогольная жировая болезнь печени: от понимания факторов риска к поиску оптимальных схем терапии

        Теплюк Д.А., Кайсина А.А., Ибрагимова Ш.И., Беставашвили А.А., Тинькова И.О., Пашкова Е.Ю., Кайбуллаева Д.А., Нерсесов А.В., Павлов Ч.С. Неалкогольная жировая болезнь печени: от понимания факторов риска к поиску оптимальных схем терапии. Consilium Medicum. 2023;25(5):325–332.
        DOI: 10.26442/20751753.2023.5.202272

        © ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.

        ________________________________________________

        Teplyuk DA, Kaisina AA, Ibragimova ShI, Bestavashvili AA, Tinkova IO, Pashkova EIu, Kaibullayeva JA, Nersesov AV, Pavlov ChS. Non-alcoholic fatty liver disease: from understanding risk factors to finding optimal treatment regimens: A review. Consilium Medicum. 2023;25(5): 325–332 . DOI: 10.26442/20751753.2023.5.202272

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          Неалкогольная жировая болезнь печени: от понимания факторов риска к поиску оптимальных схем терапии

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        • Аннотация
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        • Список литературы
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        Аннотация
        Неалкогольная жировая болезнь печени (НАЖБП) в настоящее время является одним из основных факторов риска смерти среди пациентов с заболеванием печени. На данный момент в арсенале современного клинициста есть лекарственные средства, влияющие в первую очередь на суррогатные маркеры НАЖБП. Однако ни один из этих препаратов не оказал значимого влияния на течение стеатогепатита и фиброгенез. Поиск наиболее актуальных программ модификации образа жизни по-прежнему стоит на первом месте комплексного лечения пациента. Представлен клинический случай динамического наблюдения коморбидного больного. Несмотря на комплексное лечение, добиться регресса заболевания не удалось. Терапия НАЖБП остается значимой проблемой. Необходимы поиск новых путей воздействия на течение НАЖБП и индивидуализация подходов к лечению.

        Ключевые слова: неалкогольная жировая болезнь печени, коморбидность, гепатопротекторы, лечение

        ________________________________________________

        Non-alcoholic fatty liver disease (NAFLD) is now a major risk factor for death among patients with liver disease. Currently, drugs that primarily affect surrogate markers of NAFLD are available. However, none of these drugs showed a significant effect on the course of steatohepatitis and fibrogenesis. The search for the most relevant lifestyle modification programs is still a priority in comprehensive treatment. A clinical case of follow-up of a comorbid patient is presented. Despite comprehensive treatment, disease regression was not achieved. NAFLD therapy remains a relevant issue. Finding new ways to affect the NAFLD course and individualize treatment approaches is necessary.

        Keywords: non-alcoholic fatty liver disease, comorbidity, hepatoprotective agents, treatment

        Полный текст

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        DOI:10.1016/S1499-3872(17)60019-5

        Авторы
        Д.А. Теплюк*1, А.А. Кайсина2, Ш.И. Ибрагимова1, А.А. Беставашвили1, И.О. Тинькова3, Е.Ю. Пашкова3, Д.А. Кайбуллаева2, А.В. Нерсесов2, Ч.С. Павлов1

        1 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
        2 НАО «Казахский национальный медицинский университет им. С.Д. Асфендиярова», Алматы, Казахстан;
        3 ГБУЗ «Государственная клиническая больница им. С.П. Боткина» Департамента здравоохранения г. Москвы, Москва, Россия
        *teplyouk@gmail.com

        ________________________________________________

        Daria A. Teplyuk*1, Aliya A. Kaisina2, Shabnam I. Ibragimova1, Afina A. Bestavashvili1, Irina O. Tinkova3, Evgeniia Iu. Pashkova3, Jamilya A. Kaibullayeva2, Alexander V. Nersesov2, Chavdar S. Pavlov1

        1 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
        2 Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan;
        3 Botkin State Clinical Hospital, Moscow, Russia
        *teplyouk@gmail.com


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