Цель. Оценить оригинальную методику эндовидеоскопической уретросберегающей аденомэктомии (ЭУА) для лечения пациентов с доброкачественной гиперплазией предстательной железы. Материалы и методы. С января 2021 по сентябрь 2022 г. 8 пациентам выполнена ЭУА внебрюшинным доступом. Оценены исходные данные пациентов, периоперационные и послеоперационные исходы, послеоперационные осложнения, опрос по шкалам IPSS и МИЭФ-5 и эякуляторная функция. Принципы оперативного пособия заимствованы у Ping Wang, Dan Xia, SunYi Ye, DeBo Kong, Jie Qin, TaiLe Jing, YeQing Mao, HongZhou Meng, Shuo Wang (2018 г.). Результаты. Семь (87,5%) пациентов успешно перенесли ЭУА, 1 (12,5%) пациенту потребовалась конверсия в стандартную аденомэктомию. Среднее время операции составило 171 мин (150–185), медианная кровопотеря – 232 мл (180–300). В 2 (25%) случаях потребовалась реконструкция уретры из-за ее повреждения. Среднее время катетеризации составило 1,5 дня (1–4). Сообщалось об осложнениях по Clavien–Dindo (2004 г.): 2 осложнения легкой степени (1 или 2-я группа), 1 осложнение 3а (выраженная гематурия, требующая промывания мочевого пузыря). Средняя продолжительность наблюдения составила 8,4 мес (6–11). Послеоперационный опросник показал, что показатели IPSS (p<0,1) и качества жизни (p<0,1) значительно улучшились после операции. Всего у 4 пациентов отмечалось сохранение эректильной функции, у 3 из которых отмечена нормальная эякуляция, а у 1 – ретроградная эякуляция. Заключение. ЭУА технически выполнима для пациентов с доброкачественной гиперплазией предстательной железы. Пациенты имеют короткое время катетеризации, приемлемый профиль риска, значительное улучшение функции мочеиспускания и сохранения антеградной эякуляции.
Aim. To evaluate the efficacy of endovideoscopic urethra-sparing simple prostatectomy via an extraperitoneal approach (EUSP) for patients with benign prostatic hyperplasia. Materials and methods. In the period from January 2021 until September 2022 8 patients underwent EUSP. Initial clinical datas, perioperative and postoperative outcomes, implications, IPSS questionnaires, IIEF-5 and ejaculatory datas have been evaluated. The technique of the present method was adopted from Ping Wang, Dan Xia, SunYi Ye, DeBo Kong, Jie Qin, TaiLe Jing, YeQing Mao, HongZhou Meng, Shuo Wang (2018). Results. Seven (87.5%) patients underwent EUSP successfully, 1 (12.5%) patient needed conversion into open simple prostatectomy. Mean time of operation was 171 minutes (150–185), mean blood loss was 232 ml (180–300). In 2 (25%) cases urethral reconstruction after damage was needed. Mean catheterization time was 1.5 days (1–4). According to Clavien–Dindo classification (2004) such complications were found: low degree – 2 (1 or 2 group), 3а group – 1 (severe hematuria, when bladder infusion is needed). Mean management time was 8.4 months (6–11). Results from post-operative questionnaire IPSS (p<0.1) и QoL (p<0.1) significantly improved. Totally 4 patients had secure erectile function: 3 of them had normal erection, the last one (1) – retrograde ejaculation. Conclusion. EUSP is technically applicable for patients with benign prostatic hyperplasia. Patients have shorter time of catheterization, risk profile, significant improvement of urination и support of antegrade ejaculation.
Keywords: benign prostatic hyperplasia, clinical analysis, urology, simple prostatectomy, surgery
1. Wang P, Xia D, Ye S, et al. Robotic-assisted Urethra-sparing Simple Prostatectomy Via an Extraperitoneal Approach. Urology. 2018;119:85-90. DOI:10.1016/j.urology.2018.06.005
2. Meier DE, Tarpley JL, Imediegwu OO, et al. The outcome of suprapubic prostatectomy: a contemporary series in the developing world. Urology. 1995;46(1):40-4.
DOI:10.1016/S0090-4295(99)80156-3
3. Varkarakis I, Kyriakakis Z, Delis A, et al. Long-term results of open transvesical prostatectomy from a contemporary series of patients. Urology. 2004;64(2):306-10. DOI:10.1016/j.urology.2004.03.033
4. Liu C, Zheng S, Li H, Xu K. Transurethral enucleation and resection of prostate in patients with benign prostatic hyperplasia by plasma kinetics. J Urol. 2010;184(6):2440-45. DOI:10.1016/j.juro.2010.08.037
5. Xie L, Mao Q, Chen H, et al. Transurethral vapor enucleation and resection of the prostate with plasma vaporization button electrode for the treatment of benign prostatic hyperplasia: a feasibility study. J Endourol. 2012;26(10):1264-6. DOI:10.1089/end.2012.0125
6. Giulianelli R, Gentile B, Albanesi L, et al. Bipolar Button Transurethral Enucleation of Prostate in Benign Prostate Hypertrophy Treatment: A New Surgical Technique. Urology. 2015;86(2):407-13. DOI:10.1016/j.urology.2015.03.045
7. Naspro R, Gomez Sancha F, Manica M, et al. From "gold standard" resection to reproducible "future standard" endoscopic enucleation of the prostate: what we know about anatomical enucleation. Minerva Urol Nefrol. 2017;69(5):446-58. DOI:10.23736/S0393-2249.17.02834-X
8. Kuntz RM, Lehrich K, Ahyai SA. Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol. 2008;53(1):160-6. DOI:10.1016/j.eururo.2007.08.036
9. Mariano MB, Graziottin TM, Tefilli MV. Laparoscopic Prostatectomy With Vascular Control for Benign Prostatic Hyperplasia. J Urol. 2002;167(6):2528-9.
DOI:10.1016/s0022-5347(05)65025-2
10. Leslie S, Abreu AL, Chopra S, et al. Transvesical robotic simple prostatectomy: initial clinical experience. Eur Urol. 2014;66(2):321-9. DOI:10.1016/j.eururo.2013.12.020
11. Stolzenburg JU, Kallidonis P, Qazi H, et al. Extraperitoneal approach for robotic-assisted simple prostatectomy. Urology. 2014;84(5):1099-105. DOI:10.1016/j.urology.2014.06.045
12. Pokorny M, Novara G, Geurts N, et al. Robot-assisted simple prostatectomy for treatment of lower urinary tract symptoms secondary to benign prostatic enlargement: surgical technique and outcomes in a high-volume robotic centre. Eur Urol. 2015;68(3):451-7. DOI:10.1016/j.eururo.2015.03.003
13. Pavan N, Zargar H, Sanchez-Salas R, et al. Robot-assisted Versus Standard Laparoscopy for Simple Prostatectomy: Multicenter Comparative Outcomes. Urology. 2016;91:104-10. DOI:10.1016/j.urology.2016.02.032
14. Sorokin I, Sundaram V, Singla N, et al. Robot-assisted versus open simple prostatectomy for benign prostatic hyperplasia in large glands: a propensity score-matched comparison of perioperative and short term outcomes. J Endourol. 2017;31:1164-9.
15. Dixon AR, Lord PH, Madigan MR, et al. The Madigan prostatectomy. J Urol. 1990;144:1401-3.
16. Quan C, Chang W, Chen J, et al. Laparoscopic Madigan prostatectomy. J Endourol. 2011;25(12):1879-82. DOI:10.1089/end.2011.0117
17. Abrams P, Chapple C, Khoury S, et al. International Scientific Committee. Evaluation and treatment of lower urinary tract symptoms in older men. J Urol. 2009;181(4):1779-87. DOI:10.1016/j.juro.2008.11.127
18. McVary KT, Roehrborn CG, Avins AL, et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol. 2011;185(5):1793-803. DOI:10.1016/j.juro.2011.01.074
19. Rosen RC, Cappelleri JC, Smith MD, et al. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11(6):319-26. DOI:10.1038/sj.ijir.3900472
20. Friedlander DF, Alemozaffar M, Hevelone ND, et al. Stepwise description and outcomes of bladder neck sparing during robot-assisted laparoscopic radical prostatectomy. J Urol. 2012;188(5):1754-60. DOI:10.1016/j.juro.2012.07.045
21. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. DOI:10.1097/01.sla.0000133083.54934.ae
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1. Wang P, Xia D, Ye S, et al. Robotic-assisted Urethra-sparing Simple Prostatectomy Via an Extraperitoneal Approach. Urology. 2018;119:85-90. DOI:10.1016/j.urology.2018.06.005
2. Meier DE, Tarpley JL, Imediegwu OO, et al. The outcome of suprapubic prostatectomy: a contemporary series in the developing world. Urology. 1995;46(1):40-4.
DOI:10.1016/S0090-4295(99)80156-3
3. Varkarakis I, Kyriakakis Z, Delis A, et al. Long-term results of open transvesical prostatectomy from a contemporary series of patients. Urology. 2004;64(2):306-10. DOI:10.1016/j.urology.2004.03.033
4. Liu C, Zheng S, Li H, Xu K. Transurethral enucleation and resection of prostate in patients with benign prostatic hyperplasia by plasma kinetics. J Urol. 2010;184(6):2440-45. DOI:10.1016/j.juro.2010.08.037
5. Xie L, Mao Q, Chen H, et al. Transurethral vapor enucleation and resection of the prostate with plasma vaporization button electrode for the treatment of benign prostatic hyperplasia: a feasibility study. J Endourol. 2012;26(10):1264-6. DOI:10.1089/end.2012.0125
6. Giulianelli R, Gentile B, Albanesi L, et al. Bipolar Button Transurethral Enucleation of Prostate in Benign Prostate Hypertrophy Treatment: A New Surgical Technique. Urology. 2015;86(2):407-13. DOI:10.1016/j.urology.2015.03.045
7. Naspro R, Gomez Sancha F, Manica M, et al. From "gold standard" resection to reproducible "future standard" endoscopic enucleation of the prostate: what we know about anatomical enucleation. Minerva Urol Nefrol. 2017;69(5):446-58. DOI:10.23736/S0393-2249.17.02834-X
8. Kuntz RM, Lehrich K, Ahyai SA. Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol. 2008;53(1):160-6. DOI:10.1016/j.eururo.2007.08.036
9. Mariano MB, Graziottin TM, Tefilli MV. Laparoscopic Prostatectomy With Vascular Control for Benign Prostatic Hyperplasia. J Urol. 2002;167(6):2528-9.
DOI:10.1016/s0022-5347(05)65025-2
10. Leslie S, Abreu AL, Chopra S, et al. Transvesical robotic simple prostatectomy: initial clinical experience. Eur Urol. 2014;66(2):321-9. DOI:10.1016/j.eururo.2013.12.020
11. Stolzenburg JU, Kallidonis P, Qazi H, et al. Extraperitoneal approach for robotic-assisted simple prostatectomy. Urology. 2014;84(5):1099-105. DOI:10.1016/j.urology.2014.06.045
12. Pokorny M, Novara G, Geurts N, et al. Robot-assisted simple prostatectomy for treatment of lower urinary tract symptoms secondary to benign prostatic enlargement: surgical technique and outcomes in a high-volume robotic centre. Eur Urol. 2015;68(3):451-7. DOI:10.1016/j.eururo.2015.03.003
13. Pavan N, Zargar H, Sanchez-Salas R, et al. Robot-assisted Versus Standard Laparoscopy for Simple Prostatectomy: Multicenter Comparative Outcomes. Urology. 2016;91:104-10. DOI:10.1016/j.urology.2016.02.032
14. Sorokin I, Sundaram V, Singla N, et al. Robot-assisted versus open simple prostatectomy for benign prostatic hyperplasia in large glands: a propensity score-matched comparison of perioperative and short term outcomes. J Endourol. 2017;31:1164-9.
15. Dixon AR, Lord PH, Madigan MR, et al. The Madigan prostatectomy. J Urol. 1990;144:1401-3.
16. Quan C, Chang W, Chen J, et al. Laparoscopic Madigan prostatectomy. J Endourol. 2011;25(12):1879-82. DOI:10.1089/end.2011.0117
17. Abrams P, Chapple C, Khoury S, et al. International Scientific Committee. Evaluation and treatment of lower urinary tract symptoms in older men. J Urol. 2009;181(4):1779-87. DOI:10.1016/j.juro.2008.11.127
18. McVary KT, Roehrborn CG, Avins AL, et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol. 2011;185(5):1793-803. DOI:10.1016/j.juro.2011.01.074
19. Rosen RC, Cappelleri JC, Smith MD, et al. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11(6):319-26. DOI:10.1038/sj.ijir.3900472
20. Friedlander DF, Alemozaffar M, Hevelone ND, et al. Stepwise description and outcomes of bladder neck sparing during robot-assisted laparoscopic radical prostatectomy. J Urol. 2012;188(5):1754-60. DOI:10.1016/j.juro.2012.07.045
21. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. DOI:10.1097/01.sla.0000133083.54934.ae
1ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия; 2ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
*iceberg1995@mail.ru
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Stanislav N. Volkov1, Vitaliy I. Tereshchenko1, Vladimir S. Stepanchenko1, Robert K. Mikheev*1, Olga R. Grigoryan1, Elena N. Andreeva1,2, Konstantin B. Kolontarev2
1Endocrinology Research Centre, Moscow, Russia; 2Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*iceberg1995@mail.ru