LOX-1 в роли биологического маркера и терапевтической мишени при сердечно-сосудистой патологии (обзор литературы)

Алиева А.М., Байкова И.Е., Резник Е.В., Теплова Н.В., Валиев Р.К., Гызыева М.Х., Султангалиева А.Б., Котикова И.А., Новикова Н.А., Корвяков С.А., Никитин И.Г. LOX-1 в роли биологического маркера и терапевтической мишени при сердечно-сосудистой патологии (обзор литературы). Consilium Medicum. 2024;26(10):666–673. DOI: 10.26442/20751753.2024.10.202945

© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.

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Alieva AM, Baykova IE, Reznik EV, Teplova NV, Valiev RK, Gyzyeva MKh, Sultangalieva AB, Kotikova IA, Novikova NA, Korvyakov SA, Nikitin IG. LOX-1 as a biological marker and therapeutic target in cardiovascular pathology (literature review). Consilium Medicum. 2024;26(10):666–673. DOI: 10.26442/20751753.2024.10.202945

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Аннотация

Сердечно-сосудистые заболевания (ССЗ) представляют собой глобальную медицинскую, социальную и экономическую проблему. В настоящее время продолжаются поиск и изучение новых биологических маркеров, способных обеспечить раннюю диагностику ССЗ, служить лабораторным инструментом оценки эффективности проводимого лечения или использоваться в качестве прогностических маркеров и критериев стратификации риска. Интерес ученых сосредоточен на изучении лектиноподобного рецептора 1-го типа для окисленных липопротеидов низкой плотности (LOX-1) в качестве диагностического и прогностического маркера при ССЗ. В представленном литературном обзоре подчеркивается потенциальная значимость исследования LOX-1 как диагностического и прогностического лабораторного инструмента при ССЗ. Предполагается, что будущие клинические и экспериментальные исследования подтвердят возможность применения LOX-1 в качестве дополнительного неинвазивного инструмента для диагностики и оценки прогноза у пациентов с ССЗ. Модуляция уровней и экспрессии LOX-1 с использованием фармакологических препаратов может оказаться перспективным направлением для терапии ССЗ.

Ключевые слова: сердечно-сосудистые заболевания, атеросклероз, ишемическая болезнь сердца, биологический маркер, окисленные липопротеиды низкой плотности, LOX-1

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Cardiovascular diseases (CVD) are a global medical, social and economic problem. Currently, the search and study of new biological markers that can provide early diagnosis of CVD, serve as a laboratory tool for evaluating the effectiveness of treatment or be used as prognostic markers and criteria for risk stratification continues. The interest of scientists is focused on the study of the type 1 lectin-like receptor for oxidized low-density lipoproteins (LOX-1) as a diagnostic and prognostic marker in CVD. The presented literature review highlights the potential significance of the LOX-1 study as a diagnostic and prognostic laboratory tool in CVD. It is expected that future clinical and experimental studies will confirm the possibility of using LOX-1 as an additional non-invasive tool for diagnosis and prognosis assessment in patients with CVD. Modulation of LOX-1 levels and expression using pharmacological drugs may prove to be a promising direction for the treatment of CVD.

Keywords: cardiovascular diseases, atherosclerosis, coronary heart disease, biological marker, ox-LDL, LOX-1

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Список литературы

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12. Munno M, Mallia A, Greco A, et al. Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process. Antioxidants (Basel). 2024;13(5):583. DOI:10.3390/antiox13050583
13. Barreto J, Karathanasis SK, Remaley A, et al. Role of LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1) as a Cardiovascular Risk Predictor: Mechanistic Insight and Potential Clinical Use. Arterioscler Thromb Vasc Biol. 2021;41(1):153-66. DOI:10.1161/ATVBAHA.120.315421
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2015;57(2):151-5. DOI:10.3164/jcbn.15-27
18. Zhang Q, Chu Y, Jin G, et al. Association Between LOX-1, LAL, and ACAT1 Gene Single Nucleotide Polymorphisms and Carotid Plaque in a Northern Chinese Population. Genet Test Mol Biomarkers. 2020;24(3):138-44. DOI:10.1089/gtmb.2019.0209
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2. Deng P, Fu Y, Chen M, et al. Temporal trends in inequalities of the burden of cardiovascular disease across 186 countries and territories. Int J Equity Health. 2023;22(1):164. DOI:10.1186/s12939-023-01988-2
3. Silva S, Fatumo S, Nitsch D. Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis. Syst Rev. 2024;13(1):29.
DOI:10.1186/s13643-023-02442-8
4. Alieva AM, Teplova NV, Batov MA, et al. Pentraxin-3 – a promising biological marker in heart failure: literature review. Consilium Medicum. 2022;24(1):53-9 (in Russian). DOI:10.26442/20751753.2022.1.201382
5. Alieva AM, Reznik EV, Pinchuk TV, et al. Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure. The Russian Archives of Internal Medicine. 2023;13(1):14-23 (in Russian). DOI:10.20514/2226-6704-2023-13-1-14-23
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DOI:10.18565/therapy.2022.1.60-70
7. Lubrano V, Balzan S, Papa A. LOX-1 variants modulate the severity of cardiovascular disease: state of the art and future directions. Mol Cell Biochem. Epub 2023 Oct 3. DOI:10.1007/s11010-023-04859-0
8. Sánchez-León ME, Loaeza-Reyes KJ, Matias-Cervantes CA, et al. LOX-1 in Cardiovascular Disease: A Comprehensive Molecular and Clinical Review. Int J Mol Sci. 2024;25(10):5276. DOI:10.3390/ijms25105276
9. Bagheri B, Khatibiyan Feyzabadi Z, Nouri A, et al. Atherosclerosis and Toll-Like Receptor4 (TLR4), Lectin-Like Oxidized Low-Density Lipoprotein-1 (LOX-1), and Proprotein Convertase Subtilisin/Kexin Type9 (PCSK9). Mediators Inflamm. 2024;2024:5830491. DOI:10.1155/2024/5830491
10. Truthe S, Klassert TE, Schmelz S, et al. Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions. J Innate Immun. 2024;16(1):105-32. DOI:10.1159/000535793
11. Pyrpyris N, Dimitriadis K, Beneki E, et al. LOX-1 Receptor: A Diagnostic Tool and Therapeutic Target in Atherogenesis. Curr Probl Cardiol. 2024;49(1 Pt. C):102117. DOI:10.1016/j.cpcardiol.2023.102117
12. Munno M, Mallia A, Greco A, et al. Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process. Antioxidants (Basel). 2024;13(5):583. DOI:10.3390/antiox13050583
13. Barreto J, Karathanasis SK, Remaley A, et al. Role of LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1) as a Cardiovascular Risk Predictor: Mechanistic Insight and Potential Clinical Use. Arterioscler Thromb Vasc Biol. 2021;41(1):153-66. DOI:10.1161/ATVBAHA.120.315421
14. Inoue N, Okamura T, Kokubo Y, et al. LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem. 2010;56(4):550-8. DOI:10.1373/clinchem.2009.140707
15. Markstad H, Edsfeldt A, Yao Mattison I, et al. High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke. J Am Heart Assoc. 2019;8(4):e009874. DOI:10.1161/JAHA.118.009874
16. Skarpengland T, Skjelland M, Kong XY, et al. Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack. J Am Heart Assoc. 2018;7(2):e006479. DOI:10.1161/JAHA.117.006479
17. Otsuki T, Maeda S, Mukai J, et al. Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals. J Clin Biochem Nutr.
2015;57(2):151-5. DOI:10.3164/jcbn.15-27
18. Zhang Q, Chu Y, Jin G, et al. Association Between LOX-1, LAL, and ACAT1 Gene Single Nucleotide Polymorphisms and Carotid Plaque in a Northern Chinese Population. Genet Test Mol Biomarkers. 2020;24(3):138-44. DOI:10.1089/gtmb.2019.0209
19. Salehipour P, Rezagholizadeh F, Mahdiannasser M, et al. Association of OLR1 gene polymorphisms with the risk of coronary artery disease: A systematic review and meta-analysis. Heart Lung. 2021;50(2):334-43. DOI:10.1016/j.hrtlng.2021.01.015
20. Xu X, Hou X, Liang Y, et al. The gene polymorphism of LOX1 predicts the incidence of LVH in patients with essential hypertension. Cell Physiol Biochem. 2014;33(1):88-96. DOI:10.1159/000356652
21. Sheikh MSA. Circulatory soluble LOX-1 is a novel predictor for coronary artery disease patients. Cardiovasc J Afr. 2023;34(2):104-8. DOI:10.5830/CVJA-2022-038
22. Md Sayed AS, Zhao Z, Guo L, et al. Serum lectin-like oxidized-low density lipoprotein receptor-1 and adiponectin levels are associated with coronary artery disease accompanied with metabolic syndrome. Iran Red Crescent Med J. 2014;16(8):e12106. DOI:10.5812/ircmj.12106
23. Kobayashi N, Hata N, Kume N, et al. Soluble lectin-like oxidized low-density lipoprotein receptor-1 as an early biomarker for ST elevation myocardial infarction: time-dependent comparison with other biomarkers: time-dependent comparison with other biomarkers. Circ J. 2011;75(6):1433-9. DOI:10.1253/circj. cj-10-0913
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Авторы

А.М. Алиева*¹, И.Е. Байкова¹, Е.В. Резник¹, Н.В. Теплова¹, Р.К. Валиев², М.Х. Гызыева³, А.Б. Султангалиева¹, И.А. Котикова¹, Н.А. Новикова⁴, С.А. Корвяков⁴, И.Г. Никитин¹

¹ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
²ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» Департамента здравоохранения г. Москвы, Москва, Россия;
³Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России, Пятигорск, Россия;
⁴ФГБНУ «Российский научный центр хирургии им. акад. Б.В. Петровского», Москва, Россия
*amisha_alieva@mail.ru

________________________________________________

Amina M. Alieva*¹, Irina E. Baykova¹, Elena V. Reznik¹, Natalia V. Teplova¹, Ramiz K. Valiev², Malika Kh. Gyzyeva³, Albina B. Sultangalieva¹, Irina A. Kotikova¹, Natalia A. Novikova⁴, Sergey A. Korvyakov⁴, Igor G. Nikitin¹

¹Pirogov Russian National Research Medical University, Moscow, Russia;
²Loginov Moscow Clinical Scientific Center, Moscow, Russia;
³Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University, Pyatigorsk, Russia;
⁴Petrovsky National Research Centre of Surgery, Moscow, Russia
*amisha_alieva@mail.ru

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