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Известный и неизвестный гимекромон
Плотникова Е.Ю. Известный и неизвестный гимекромон. Consilium Medicum. 2024;26(5):324–330.
DOI: 10.26442/20751753.2024.5.202877
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
DOI: 10.26442/20751753.2024.5.202877
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
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Plotnikova EYu. Known and unknown hymecromone: A review. Consilium Medicum. 2024;26(5):324–330.
DOI: 10.26442/20751753.2024.5.202877
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Аннотация
Гимекромон (4-MU) является признанным средством, применяемым в настоящее время в клинической практике. С 1960 г. гимекромон используют во многих странах как холеретик и холеспазмолитик, это одобренный для применения у людей при патологии билиарного тракта препарат. В обзоре представлены как традиционные европейские и отечественные исследования селективного спазмолитического и желчегонного свойств гимекромона, благодаря которым гимекромон является препаратором выбора для лечения заболеваний желчевыводящих путей, так и новые фундаментальные и клинические исследования многочисленных плейотропных эффектов 4-MU, связанных с ингибированием гиалуроновой кислоты и многими другими свойствами этой интересной молекулы. К ним относятся антибактериальные, противовирусные и неспецифические противовоспалительные эффекты. Продемонстрированы положительные результаты при нарушениях углеводного и липидного обменах, при аутоиммунных заболеваниях, болезнях печени, сердца, почек. Представлены многочисленные исследования in vitro и in vivo при раках поджелудочной железы, предстательной железы, кожи, пищевода, молочной железы, печени, яичников, костей, при метастатических поражениях, лейкемии, аутоиммунных и воспалительных заболеваниях. Показано назначение гимекромона не только в качестве холеретика и холеспазмолитика, но и как холесептика при холангитах, хронических холециститах, в том числе при описторхозе, что не противоречит его инструкции. На отечественном фармацевтическом рынке представлен препарат с гимекромоном – Одекромон® (таблетки 200 мг), который «пришел» на смену оригинальному препарату и является его полноценным генериком.
Ключевые слова: гимекромон, холеретик, холеспазмолитик, дисфункция желчевыводящих путей, желчнокаменная болезнь, постхолецистэктомический синдром, гиалуроновая кислота
Ключевые слова: гимекромон, холеретик, холеспазмолитик, дисфункция желчевыводящих путей, желчнокаменная болезнь, постхолецистэктомический синдром, гиалуроновая кислота
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Hymecromone (4-MU) is a recognized agent currently used in clinical practice. Since 1960, hymecromone has been used in many countries as a choleretic and cholespasmolytic, a drug approved for use in humans with biliary tract disorders. The review presents both traditional European and Russian studies of the selective antispasmodic and choleretic properties of hymecromone, due to which hymecromone is the drug of choice for the treatment of biliary tract diseases, as well as new fundamental and clinical studies of numerous pleiotropic effects of 4-MU associated with inhibition of hyaluronic acid and many other properties of this exciting molecule. These include antibacterial, antiviral, and nonspecific anti-inflammatory effects. Positive results have been demonstrated in carbohydrate and lipid metabolism disorders, autoimmune diseases, as well as liver, heart, and kidney diseases. Numerous in vitro and in vivo studies have been presented in pancreatic, prostate, skin, esophagus, breast, liver, ovary, bone cancers, metastatic lesions, leukemia, autoimmune and inflammatory diseases. Hymecromone is indicated not only as a choleretic and cholespasmolytic but also as a choleseptic in cholangitis and chronic cholecystitis, including opisthorchiasis, which does not disagree with its label. Odecromone® (hymecromone, tablets 200 mg) is available on the Russian market; it replaced the originator drug and is its fully equivalent generic.
Keywords: hymecromone, choleretic, cholespasmolytic, biliary tract dysfunction, gallstone disease, postcholecystectomy syndrome, hyaluronic acid
Полный текст
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3. Garrett ER, Venitz J, Eberst K, Cerda JJ. Pharmacokinetics and bioavailabilities of hymecromone in human volunteers. Biopharm Drug Dispos. 1993;14(1):13-39. DOI:10.1002/bdd.2510140103
4. Nagy N, Kuipers HF, Frymoyer AR, et al. 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 2015;6:123. DOI:10.3389/fimmu.2015.00123
5. Hoffmann RM, Schwarz G, Pohl C, et al. Gallensäure-unabhängige Wirkung von Hymecromon auf die Gallesekretion und die Motilität der Gallenwege [Bile acid-independent effect of hymecromone on bile secretion and common bile duct motility]. Dtsch Med Wochenschr. 2005;130(34–35):1938-43 [Article in German]. DOI:10.1055/s-2005-872606
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12. Polenov AM, Pogromov AP. Gimekromon (odeston) v terapii bol'nykh s postkholetsistektomicheskoi disfunktsiei sfinktera Oddi. Eksperimental'naia i Klinicheskaia Gastroenterologiia. 2003;(5):163-4 (in Russian).
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16. Melliou E, Magiatis P, Mitaku S, et al. Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. J Nat Prod. 2005;68(1):78-82. DOI:10.1021/np0497447
17. Kawase M, Varu B, Shah A, et al. Antimicrobial activity of new coumarin derivatives. Arzneimittelforschung. 2001;51(1):67-71. DOI:10.1055/s-0031-1300004
18. El-Attar MS, Sadeek SA, Abd El-Hamid SM, Elshafie HS. Spectroscopic Analyses and Antimicrobial Activity of Novel Ciprofloxacin and 7-Hydroxy-4-methylcoumarin, the Plant-Based Natural Benzopyrone Derivative. Int J Mol Sci. 2022;23(14):8019. DOI:10.3390/ijms23148019
19. Singh LK, Priyanka, Singh V, Katiyar D. Design, synthesis and biological evaluation of some new coumarin derivatives as potential antimicrobial agents. Med Chem.
2015;11(2):128-34. DOI:10.2174/1573406410666140902110452
20. McKallip RJ, Ban H, Uchakina ON. Treatment with the hyaluronic Acid synthesis inhibitor 4-methylumbelliferone suppresses LPS-induced lung inflammation. Inflammation. 2015;38(3):1250-9. DOI:10.1007/s10753-014-0092-y
21. Barnes HW, Demirdjian S, Haddock NL, et al. Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection. Matrix Biol. 2023;116:49-66. DOI:10.1016/j.matbio.2023.02.001
22. McKallip RJ, Hagele HF, Uchakina ON. Treatment with the hyaluronic acid synthesis inhibitor 4-methylumbelliferone suppresses SEB-induced lung inflammation. Toxins (Basel). 2013;5(10):1814-26. DOI:10.3390/toxins5101814
23. Arai E, Nishida Y, Wasa J, et al. Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. Br J Cancer. 2011;105(12):1839-49. DOI:10.1038/bjc.2011.459
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2017;174(19):3284-301. DOI:10.1111/bph.13947
25. Collum SD, Molina JG, Hanmandlu A, et al. Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema. Dis Model Mech. 2019;12(5):dmm038711. DOI:10.1242/dmm.038711
26. Yang S, Ling Y, Zhao F, et al. Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression. Signal Transduct Target Ther. 2022;7(1):91. DOI:10.1038/s41392-022-00952-w
27. Jiang D, Liang J, Noble PW. Hyaluronan as an immune regulator in human diseases. Physiol Rev. 2011;91(1):221-64. DOI:10.1152/physrev.00052.2009
28. Itano N, Atsumi F, Sawai T, et al. Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proc Natl Acad Sci U S A. 2002;99(6):3609-14. DOI:10.1073/pnas.052026799
29. Ruppert SM, Hawn TR, Arrigoni A, et al. Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation. Immunol Res.
2014;58(2-3):186-92. DOI:10.1007/s12026-014-8495-2
30. Stern R, Asari AA, Sugahara KN. Hyaluronan fragments: an information-rich system. Eur J Cell Biol. 2006;85(8):699-715. DOI:10.1016/j.ejcb.2006.05.009
31. Laurent TC, Laurent UB, Fraser JR. The structure and function of hyaluronan: An overview. Immunol Cell Biol. 1996;74(2):A1-7. DOI:10.1038/icb.1996.32
32. Scott JE. Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues. FASEB J. 1992;6(9):2639-45.
33. Tasanarong A, Khositseth S, Thitiarchakul S. The mechanism of increased vascular permeability in renal ischemic reperfusion injury: potential role of angiopoietin-1 and hyaluronan. J Med Assoc Thai. 2009;92(9):1150-8.
34. Khan AI, Kerfoot SM, Heit B, et al. Role of CD44 and hyaluronan in neutrophil recruitment. J Immunol. 2004;173(12):7594-601. DOI:10.4049/jimmunol.173.12.7594
35. Evanko SP, Potter-Perigo S, Bollyky PL, et al. Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration. Matrix Biol. 2012;31(2):90-100. DOI:10.1016/j.matbio.2011.10.004
36. Powell JD, Horton MR. Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal. Immunol Res. 2005;31(3):207-18. DOI:10.1385/IR:31:3:207
37. Tesar BM, Jiang D, Liang J, et al. The role of hyaluronan degradation products as innate alloimmune agonists. Am J Transplant. 2006;6(11):2622-35.
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Авторы
Е.Ю. Плотникова*
ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия
*eka-pl@rambler.ru
ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия
*eka-pl@rambler.ru
________________________________________________
Ekaterina Yu. Plotnikova*
Kemerovo State Medical University, Kemerovo, Russia
*eka-pl@rambler.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.