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Взаимосвязь анемии с когнитивными и тревожно-депрессивными расстройствами
Взаимосвязь анемии с когнитивными и тревожно-депрессивными расстройствами
Петрова М.М., Шимохина Н.Ю., Суворова А.А. Взаимосвязь анемии с когнитивными и тревожно-депрессивными расстройствами. Consilium Medicum. 2026;28(2):113–118. DOI: 10.26442/20751753.2026.2.203554
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Аннотация
Анемия, когнитивные нарушения и тревожно-депрессивные расстройства представляют собой серьезную медико-социальную и экономическую проблему, частота встречаемости которой увеличивается с возрастом пациента. Данные состояния существенно снижают качество жизни больных, повышают риск развития сопутствующих заболеваний и увеличивают вероятность преждевременной смертности. Несмотря на высокий уровень распространения и значительное влияние на здоровье населения, причины возникновения и клиническое значение сочетания всех указанных состояний требуют дальнейшего изучения. Возможными механизмами взаимозависимости анемии, когнитивной дисфункции и тревоги с депрессией могут выступать общие этиопатогенетические факторы, включающие низкий социальный и экономический статус, недостаточный образовательный уровень и гиподинамию. Дополнительно отмечается сходство молекулярных механизмов патологического процесса, проявляющееся возрастзависимой патологией (например, воспалением, оксидативным стрессом, нейродегенерацией тканей мозга и органов-мишеней), недостаточностью микронутриентов (дефицитом железа, витаминов группы B, фолатов) и эндокринологическими нарушениями (гипотиреозом, андрогенным дефицитом). Кроме того, указанные патологии характеризуются низкой частотой диагностики и, соответственно, отсутствием адекватного лечения, что усугубляет течение каждого заболевания и ухудшает прогноз для пациентов. Комплексное изучение природы связи между анемией, когнитивным снижением и тревожными депрессивными симптомами имеет важное значение для разработки эффективных диагностических подходов и оптимальных схем терапии, направленных на улучшение качества жизни и снижение уровня инвалидизации среди пожилых лиц и пациентов с хроническими заболеваниями. Целью исследования является систематизация современных научных представлений о механизмах взаимодействия и клинических последствиях совместного течения анемии, когнитивного дефицита и психоэмоциональных нарушений. Проведен критический анализ доступной научной литературы, посвященной изучению особенностей взаимосвязи указанных состояний в реальной клинической практике. Обзорная статья представляет интерес для врачей разных специальностей, исследователей и организаторов здравоохранения, заинтересованных в повышении эффективности профилактики, диагностики и лечения комплексных медицинских проблем пожилого возраста и хронических болезней.
Ключевые слова: анемия, когнитивные нарушения, тревожные расстройства, депрессивные расстройства, витамин В12
Keywords: anemia, cognitive impairment, anxiety disorders, depressive disorder, vitamin B12 deficiency
Ключевые слова: анемия, когнитивные нарушения, тревожные расстройства, депрессивные расстройства, витамин В12
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Keywords: anemia, cognitive impairment, anxiety disorders, depressive disorder, vitamin B12 deficiency
Полный текст
Список литературы
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2. Park GN, Kim JO, Oh JW, Lee S. Association between anemia and depression: The 2014, 2016, and 2018 Korea National Health and Nutrition Examination Survey. J Affect Disord. 2022;312:86-91. DOI:10.1016/j.jad.2022.06.015
3. Oh J, Lee T, Chung ES et al. Development of depression detection algorithm using text scripts of routine psychiatric interview. Front Psychiatry. 2024;14:1256571. DOI:10.3389/fpsyt.2023.1256571
4. Kim GE, Jo MW, Shin YW. Increased prevalence of depression in South Korea from 2002 to 2013. Sci Rep. 2020;10(1):16979. DOI:10.1038/s41598-020-74119-4
5. Kaegi-Braun N, Mueller M, Schuetz P et al. Evaluation of nutritional support and in-hospital mortality in patients with malnutrition. JAMA Netw Open. 2021;4(1):e2033433. DOI:10.1001/jamanetworkopen.2020.33433
6. Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci. 2019;1450(1):15-31. DOI:10.1111/nyas.14092
7. Michalak SS, Sterna W. Coexistence and clinical implications of anemia and depression in the elderly population. Psychiatr Pol. 2023;57(3):517-28. DOI:10.12740/PP/147079
8. Albert KM, Newhouse PA. Estrogen, stress, and depression: Cognitive and biological interactions. Annu Rev Clin Psychol. 2019;15:399-423. DOI:10.1146/annurev-clinpsy-050718-095557
9. Wang J, Wang C, Li X et al. Association of anemia with cognitive function and dementia among older adults: The role of inflammation. J Alzheimers Dis. 2023;96(1):125-34. DOI:10.3233/JAD-230483
10. Knezevic E, Nenic K, Milanovic V, Knezevic NN. The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells. 2023;12(23):2726. DOI:10.3390/cells12232726
11. Lee YJ, Kim HB. Association between anaemia and adult depression: A systematic review and meta-analysis of observational studies. J Epidemiol Community Health. 2020;74(7):565-72. DOI:10.1136/jech-2020-213842
12. Hidese S, Saito K, Asano S, Kunugi H. Association between iron-deficiency anemia and depression: A web-based Japanese investigation. Psychiatry Clin Neurosci. 2018;72(7):513-21. DOI:10.1111/pcn.12656
13. Lever-van Milligen BA, Vogelzangs N, Smit JH, Penninx BW. Hemoglobin levels in persons with depressive and/or anxiety disorders. J Psychosom Res. 2014;76(4):317-21. DOI:10.1016/j.jpsychores.2014.01.004
14. Kang SY, Kim HB, Sunwoo S. Association between anemia and maternal depression: A systematic review and meta-analysis. J Psychiatr Res. 2020;122:88-96. DOI:10.1016/j.jpsychires.2020.01.001
15. Ahmed T, Lamoureux-Lamarche C, Berbiche D, Vasiliadis HM. The association between anemia and depression in older adults and the role of treating anemia. Brain Behav. 2023;13(5):e2973. DOI:10.1002/brb3.2973
16. Si T, Ma X, Zhu W, Zhou Y. Comment on: Association between anemia and depression: results from NHANES 2005–2018 and Mendelian randomization analyses. Ann Hematol. 2024;103(2):689-91. DOI:10.1007/s00277-023-05496-9
17. Costantini L, Pasquarella C, Odone A et al. Screening for depression in primary care with Patient Health Questionnaire-9 (PHQ-9): A systematic review. J Affect Disord. 2021;279:473-83. DOI:10.1016/j.jad.2020.09.131
18. Bekhbat M, Neigh GN. Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety. Brain Behav Immun. 2018;67:1-12. DOI:10.1016/j.bbi.2017.02.006
19. Morssinkhof MWL, van Wylick DW, Priester-Vink S, et al. Associations between sex hormones, sleep problems and depression: A systematic review. Neurosci Biobehav Rev. 2020;118:669-80. DOI:10.1016/j.neubiorev.2020.08.006
20. Wassef A, Nguyen QD, St-André M. Anaemia and depletion of iron stores as risk factors for postpartum depression: A literature review. J Psychosom Obstet Gynaecol. 2019;40(1):19-28. DOI:10.1080/0167482X.2018.1427725
21. Kunugi H. Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psychiatry Clin Neurosci. 2023;77(8):420-33. DOI:10.1111/pcn.13551
22. Peskovets RD, Shtarik SY, Evsyukov AA. Prevalence of anxiety disorders in general medical network and their relationship with risk factors of cardiovascular diseases. Siberian Medical Review. 2019;(6):73-9 (in Russian). DOI:10.20333/2500136-2019-6-73-79
23. Shimokhina NY, Savchenko AA, Petrova MM. Peculiarities of platelet metabolism in patients with acute coronary syndrome with anxiety-depressive disorders and informativity of enzymes in the forecast of development of cardiovascular complications. Pharmaceuticals (Basel). 2020;13(8):169. DOI:10.3390/ph13080169
24. Ovsyannikov ES, Drobysheva ES, Tokmachev RE. Study of the severity of anxiety and depression in patients with chronic heart failure combined with anemia. Russian Cardiology Bulletin. 2022;17(2-2):87 (in Russian).
25. Lin PY, Li LC, Wang LJ et al. Lack of association between erythropoietin treatment and risk of depression in patients with end-stage kidney disease on maintenance dialysis: A nationwide database study in Taiwan. Ther Adv Chronic Dis. 2021;12:2040622321995690. DOI:10.1177/2040622321995690
26. Liu M, He E, Fu X et al. Cerebral blood flow self-regulation in depression. J Affect Disord. 2022;302:324-31. DOI:10.1016/j.jad.2022.01.057
27. Chiappelli J, Adhikari BM, Kvarta MD et al. Depression, stress and regional cerebral blood flow. J Cereb Blood Flow Metab. 2023;43(5):791-800. DOI:10.1177/0271678X221148979
28. Oh J, Chae JH, Kim TS. Age-specific association between body mass index and depression: The Korea National Health and Nutrition Examination Survey 2014. Int J Obes (Lond). 2018;42(3):327-33. DOI:10.1038/ijo.2017.234
29. Yu B, Zhang X, Wang C et al. Trends in depression among adults in the United States, NHANES 2005–2016. J Affect Disord. 2020;263:609-20. DOI:10.1016/j.jad.2019.11.036
30. Bruserud Ø, Vo AK, Rekvam H. Hematopoiesis, inflammation and aging-the biological background and clinical impact of anemia and increased c-reactive protein levels on elderly individuals. J Clin Med. 2022;11(3):706. DOI:10.3390/jcm11030706
31. Xie J, Van Hoecke L, Vandenbroucke RE. The impact of systemic inflammation on Alzheimer's disease pathology. Front Immunol. 2022;12:796867. DOI:10.3389/fimmu.2021.796867
32. Chen YH, Karimi M, Rutten-van Mölken MPMH. The disease burden of multimorbidity and its interaction with educational level. PLoS One. 2020;15(12):e0243275. DOI:10.1371/journal.pone.0243275
33. Girelli D, Marchi G, Camaschella C. Anemia in the elderly. Hemasphere. 2018;2(3):e40. DOI:10.1097/HS9.0000000000000040
34. Grande G, Marengoni A, Vetrano DL et al. Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. Alzheimers Dement. 2021;17(5):768-76. DOI:10.1002/alz.12237
35. Burtscher J, Mallet RT, Burtscher M, Millet GP. Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Res Rev. 2021;68:101343. DOI:10.1016/j.arr.2021.101343
36. Kung WM, Yuan SP, Lin MS, et al. Anemia and the risk of cognitive impairment: An updated systematic review and meta-analysis. Brain Sci. 2021;11(6):777. DOI:10.3390/brainsci11060777
37. Shobatake R, Ota H, Takahashi N et al. The impact of intermittent hypoxia on metabolism and cognition. Int J Mol Sci. 2022;23(21):12957. DOI:10.3390/ijms232112957
38. Thakur S, Dhapola R, Sarma P et al. Neuroinflammation in Alzheimer's disease: Current progress in molecular signaling and therapeutics. Inflammation. 2023;46(1):1-17. DOI:10.1007/s10753-022-01721-1
39. Wang M, Pan W, Xu Y et al. Microglia-mediated neuroinflammation: A potential target for the treatment of cardiovascular diseases. J Inflamm Res. 2022;15:3083-94. DOI:10.2147/JIR.S350109
40. Fabrício DM, Chagas MHN, Diniz BS. Frailty and cognitive decline. Transl Res. 2020;221:58-64. DOI:10.1016/j.trsl.2020.01.002
41. Guo L, Tian J, Du H. Mitochondrial dysfunction and synaptic transmission failure in Alzheimer's disease. J Alzheimers Dis. 2017;57(4):1071-86. DOI:10.3233/JAD-160702
42. Wang Z, Zhu W, Xing Y et al. B vitamins and prevention of cognitive decline and incident dementia: A systematic review and meta-analysis. Nutr Rev. 2022;80(4):931-49. DOI:10.1093/nutrit/nuab057
43. Teleanu DM, Niculescu AG, Lungu II et al. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int J Mol Sci. 2022;23(11):5938. DOI:10.3390/ijms23115938
44. Lauer AA, Grimm HS, Apel B et al. Mechanistic link between vitamin B12 and Alzheimer's disease. Biomolecules. 2022;12(1):129. DOI:10.3390/biom12010129.4
45. Gao W, Zhu WW, Yu YH, Wang J. Plasma homocysteine level, estradiol level, and brain atrophy: A Mendelian randomization study. Cereb Cortex. 2024;34(3):bhae112. DOI:10.1093/cercor/bhae112
46. Qiang YX, Deng YT, Zhang YR et al. Associations of blood cell indices and anemia with risk of incident dementia: A prospective cohort study of 313,448 participants. Alzheimers Dement. 2023;19(9):3965-76. DOI:10.1002/alz.13088
47. Jatoi S, Hafeez A, Riaz SU et al. Low vitamin B12 levels: An underestimated cause of minimal cognitive impairment and dementia. Cureus. 2020;12(2):e6976. DOI:10.7759/cureus.6976
48. Green R, Miller JW. Vitamin B12 deficiency. Vitam Horm. 2022;119:405-39. DOI:10.1016/bs.vh.2022.02.003
49. Luzzi S, Cherubini V, Falsetti L et al. Homocysteine, cognitive functions, and degenerative dementias: State of the art. Biomedicines. 2022;10(11):2741. DOI:10.3390/biomedicines10112741
50. Gyawali P, Bhatt RD, Karmacharya RM et al. High burden of vitamin B12 deficiency among adults and elderly. J Nepal Health Res Counc. 2023;20(3):702-7. DOI:10.33314/jnhrc.v20i3.4407
51. Kılcı C, Olcay L. A common problem in infants: Vitamin B12 deficiency. Turk J Pediatr. 2023;65(6):931-8. DOI:10.24953/turkjped.2022.399
52. Sahu P, Thippeswamy H, Chaturvedi SK. Neuropsychiatric manifestations in vitamin B12 deficiency. Vitam Horm. 2022;119:457-70. DOI:10.1016/bs.vh.2022.01.001
53. Siddique M, Parvez MA, Zafar H et al. Prevalence of vitamin B12 deficiency in hypothyroid patients. Annals of Punjab Medical College. 2017;11(3):252-6. DOI:10.29054/apmc/2017.206
54. Couderc AL, Camalet J, Schneider S, et al. Cobalamin deficiency in the elderly: Aetiology and management: A study of 125 patients in a geriatric hospital. J Nutr Health Aging. 2015;19(2):234-9. DOI:10.1007/s12603-014-0525-1
55. Yang W, Cai X, Wu H, Ji L. Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: A meta-analysis. J Diabetes. 2019;11(9):729-43. DOI:10.1111/1753-0407.12900
56. Spence JD. Metabolic vitamin B12 deficiency: A missed opportunity to prevent dementia and stroke. Nutr Res. 2016;36(2):109-16. DOI:10.1016/j.nutres.2015.10.003
57. Wong CW. Vitamin B12 deficiency in the elderly: Is it worth screening? Hong Kong Med J. 2015;21(2):155-64. DOI:10.12809/hkmj144383
58. Resolution of the Advisory Board "Deficiency/Deficit of vitamin B12 in clinical practice". Russian Journal of Preventive Medicine. 2023;26(1):109-13 (in Russian). DOI:10.17116/profmed202326011109
2. Park GN, Kim JO, Oh JW, Lee S. Association between anemia and depression: The 2014, 2016, and 2018 Korea National Health and Nutrition Examination Survey. J Affect Disord. 2022;312:86-91. DOI:10.1016/j.jad.2022.06.015
3. Oh J, Lee T, Chung ES et al. Development of depression detection algorithm using text scripts of routine psychiatric interview. Front Psychiatry. 2024;14:1256571. DOI:10.3389/fpsyt.2023.1256571
4. Kim GE, Jo MW, Shin YW. Increased prevalence of depression in South Korea from 2002 to 2013. Sci Rep. 2020;10(1):16979. DOI:10.1038/s41598-020-74119-4
5. Kaegi-Braun N, Mueller M, Schuetz P et al. Evaluation of nutritional support and in-hospital mortality in patients with malnutrition. JAMA Netw Open. 2021;4(1):e2033433. DOI:10.1001/jamanetworkopen.2020.33433
6. Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci. 2019;1450(1):15-31. DOI:10.1111/nyas.14092
7. Michalak SS, Sterna W. Coexistence and clinical implications of anemia and depression in the elderly population. Psychiatr Pol. 2023;57(3):517-28. DOI:10.12740/PP/147079
8. Albert KM, Newhouse PA. Estrogen, stress, and depression: Cognitive and biological interactions. Annu Rev Clin Psychol. 2019;15:399-423. DOI:10.1146/annurev-clinpsy-050718-095557
9. Wang J, Wang C, Li X et al. Association of anemia with cognitive function and dementia among older adults: The role of inflammation. J Alzheimers Dis. 2023;96(1):125-34. DOI:10.3233/JAD-230483
10. Knezevic E, Nenic K, Milanovic V, Knezevic NN. The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells. 2023;12(23):2726. DOI:10.3390/cells12232726
11. Lee YJ, Kim HB. Association between anaemia and adult depression: A systematic review and meta-analysis of observational studies. J Epidemiol Community Health. 2020;74(7):565-72. DOI:10.1136/jech-2020-213842
12. Hidese S, Saito K, Asano S, Kunugi H. Association between iron-deficiency anemia and depression: A web-based Japanese investigation. Psychiatry Clin Neurosci. 2018;72(7):513-21. DOI:10.1111/pcn.12656
13. Lever-van Milligen BA, Vogelzangs N, Smit JH, Penninx BW. Hemoglobin levels in persons with depressive and/or anxiety disorders. J Psychosom Res. 2014;76(4):317-21. DOI:10.1016/j.jpsychores.2014.01.004
14. Kang SY, Kim HB, Sunwoo S. Association between anemia and maternal depression: A systematic review and meta-analysis. J Psychiatr Res. 2020;122:88-96. DOI:10.1016/j.jpsychires.2020.01.001
15. Ahmed T, Lamoureux-Lamarche C, Berbiche D, Vasiliadis HM. The association between anemia and depression in older adults and the role of treating anemia. Brain Behav. 2023;13(5):e2973. DOI:10.1002/brb3.2973
16. Si T, Ma X, Zhu W, Zhou Y. Comment on: Association between anemia and depression: results from NHANES 2005–2018 and Mendelian randomization analyses. Ann Hematol. 2024;103(2):689-91. DOI:10.1007/s00277-023-05496-9
17. Costantini L, Pasquarella C, Odone A et al. Screening for depression in primary care with Patient Health Questionnaire-9 (PHQ-9): A systematic review. J Affect Disord. 2021;279:473-83. DOI:10.1016/j.jad.2020.09.131
18. Bekhbat M, Neigh GN. Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety. Brain Behav Immun. 2018;67:1-12. DOI:10.1016/j.bbi.2017.02.006
19. Morssinkhof MWL, van Wylick DW, Priester-Vink S, et al. Associations between sex hormones, sleep problems and depression: A systematic review. Neurosci Biobehav Rev. 2020;118:669-80. DOI:10.1016/j.neubiorev.2020.08.006
20. Wassef A, Nguyen QD, St-André M. Anaemia and depletion of iron stores as risk factors for postpartum depression: A literature review. J Psychosom Obstet Gynaecol. 2019;40(1):19-28. DOI:10.1080/0167482X.2018.1427725
21. Kunugi H. Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psychiatry Clin Neurosci. 2023;77(8):420-33. DOI:10.1111/pcn.13551
22. Песковец РД, Штарик СЮ, Евсюков АА. Распространенность тревожных расстройств в общемедицинской сети и их связь с сердечно-сосудистыми заболеваниями. Сибирское медицинское обозрение. 2019;(6):73-9 [Peskovets RD, Shtarik SY, Evsyukov AA. Prevalence of anxiety disorders in general medical network and their relationship with risk factors of cardiovascular diseases. Siberian Medical Review. 2019;(6):73-9 (in Russian)]. DOI:10.20333/2500136-2019-6-73-79
23. Shimokhina NY, Savchenko AA, Petrova MM. Peculiarities of platelet metabolism in patients with acute coronary syndrome with anxiety-depressive disorders and informativity of enzymes in the forecast of development of cardiovascular complications. Pharmaceuticals (Basel). 2020;13(8):169. DOI:10.3390/ph13080169
24. Овсянников Е.С., Дробышева Е.С., Токмачев Р.Е. Исследование выраженности тревоги и депрессии у больных хронической сердечной недостаточностью в сочетании с анемией. Кардиологический вестник. 2022;17(2-2):87 [Ovsyannikov ES, Drobysheva ES, Tokmachev RE. Study of the severity of anxiety and depression in patients with chronic heart failure combined with anemia. Russian Cardiology Bulletin. 2022;17(2-2):87 (in Russian)].
25. Lin PY, Li LC, Wang LJ et al. Lack of association between erythropoietin treatment and risk of depression in patients with end-stage kidney disease on maintenance dialysis: A nationwide database study in Taiwan. Ther Adv Chronic Dis. 2021;12:2040622321995690. DOI:10.1177/2040622321995690
26. Liu M, He E, Fu X et al. Cerebral blood flow self-regulation in depression. J Affect Disord. 2022;302:324-31. DOI:10.1016/j.jad.2022.01.057
27. Chiappelli J, Adhikari BM, Kvarta MD et al. Depression, stress and regional cerebral blood flow. J Cereb Blood Flow Metab. 2023;43(5):791-800. DOI:10.1177/0271678X221148979
28. Oh J, Chae JH, Kim TS. Age-specific association between body mass index and depression: The Korea National Health and Nutrition Examination Survey 2014. Int J Obes (Lond). 2018;42(3):327-33. DOI:10.1038/ijo.2017.234
29. Yu B, Zhang X, Wang C et al. Trends in depression among adults in the United States, NHANES 2005–2016. J Affect Disord. 2020;263:609-20. DOI:10.1016/j.jad.2019.11.036
30. Bruserud Ø, Vo AK, Rekvam H. Hematopoiesis, inflammation and aging-the biological background and clinical impact of anemia and increased c-reactive protein levels on elderly individuals. J Clin Med. 2022;11(3):706. DOI:10.3390/jcm11030706
31. Xie J, Van Hoecke L, Vandenbroucke RE. The impact of systemic inflammation on Alzheimer's disease pathology. Front Immunol. 2022;12:796867. DOI:10.3389/fimmu.2021.796867
32. Chen YH, Karimi M, Rutten-van Mölken MPMH. The disease burden of multimorbidity and its interaction with educational level. PLoS One. 2020;15(12):e0243275. DOI:10.1371/journal.pone.0243275
33. Girelli D, Marchi G, Camaschella C. Anemia in the elderly. Hemasphere. 2018;2(3):e40. DOI:10.1097/HS9.0000000000000040
34. Grande G, Marengoni A, Vetrano DL et al. Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. Alzheimers Dement. 2021;17(5):768-76. DOI:10.1002/alz.12237
35. Burtscher J, Mallet RT, Burtscher M, Millet GP. Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Res Rev. 2021;68:101343. DOI:10.1016/j.arr.2021.101343
36. Kung WM, Yuan SP, Lin MS, et al. Anemia and the risk of cognitive impairment: An updated systematic review and meta-analysis. Brain Sci. 2021;11(6):777. DOI:10.3390/brainsci11060777
37. Shobatake R, Ota H, Takahashi N et al. The impact of intermittent hypoxia on metabolism and cognition. Int J Mol Sci. 2022;23(21):12957. DOI:10.3390/ijms232112957
38. Thakur S, Dhapola R, Sarma P et al. Neuroinflammation in Alzheimer's disease: Current progress in molecular signaling and therapeutics. Inflammation. 2023;46(1):1-17. DOI:10.1007/s10753-022-01721-1
39. Wang M, Pan W, Xu Y et al. Microglia-mediated neuroinflammation: A potential target for the treatment of cardiovascular diseases. J Inflamm Res. 2022;15:3083-94. DOI:10.2147/JIR.S350109
40. Fabrício DM, Chagas MHN, Diniz BS. Frailty and cognitive decline. Transl Res. 2020;221:58-64. DOI:10.1016/j.trsl.2020.01.002
41. Guo L, Tian J, Du H. Mitochondrial dysfunction and synaptic transmission failure in Alzheimer's disease. J Alzheimers Dis. 2017;57(4):1071-86. DOI:10.3233/JAD-160702
42. Wang Z, Zhu W, Xing Y et al. B vitamins and prevention of cognitive decline and incident dementia: A systematic review and meta-analysis. Nutr Rev. 2022;80(4):931-49. DOI:10.1093/nutrit/nuab057
43. Teleanu DM, Niculescu AG, Lungu II et al. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int J Mol Sci. 2022;23(11):5938. DOI:10.3390/ijms23115938
44. Lauer AA, Grimm HS, Apel B et al. Mechanistic link between vitamin B12 and Alzheimer's disease. Biomolecules. 2022;12(1):129. DOI:10.3390/biom12010129.4
45. Gao W, Zhu WW, Yu YH, Wang J. Plasma homocysteine level, estradiol level, and brain atrophy: A Mendelian randomization study. Cereb Cortex. 2024;34(3):bhae112. DOI:10.1093/cercor/bhae112
46. Qiang YX, Deng YT, Zhang YR et al. Associations of blood cell indices and anemia with risk of incident dementia: A prospective cohort study of 313,448 participants. Alzheimers Dement. 2023;19(9):3965-76. DOI:10.1002/alz.13088
47. Jatoi S, Hafeez A, Riaz SU et al. Low vitamin B12 levels: An underestimated cause of minimal cognitive impairment and dementia. Cureus. 2020;12(2):e6976. DOI:10.7759/cureus.6976
48. Green R, Miller JW. Vitamin B12 deficiency. Vitam Horm. 2022;119:405-39. DOI:10.1016/bs.vh.2022.02.003
49. Luzzi S, Cherubini V, Falsetti L et al. Homocysteine, cognitive functions, and degenerative dementias: State of the art. Biomedicines. 2022;10(11):2741. DOI:10.3390/biomedicines10112741
50. Gyawali P, Bhatt RD, Karmacharya RM et al. High burden of vitamin B12 deficiency among adults and elderly. J Nepal Health Res Counc. 2023;20(3):702-7. DOI:10.33314/jnhrc.v20i3.4407
51. Kılcı C, Olcay L. A common problem in infants: Vitamin B12 deficiency. Turk J Pediatr. 2023;65(6):931-8. DOI:10.24953/turkjped.2022.399
52. Sahu P, Thippeswamy H, Chaturvedi SK. Neuropsychiatric manifestations in vitamin B12 deficiency. Vitam Horm. 2022;119:457-70. DOI:10.1016/bs.vh.2022.01.001
53. Siddique M, Parvez MA, Zafar H et al. Prevalence of vitamin B12 deficiency in hypothyroid patients. Annals of Punjab Medical College. 2017;11(3):252-6. DOI:10.29054/apmc/2017.206
54. Couderc AL, Camalet J, Schneider S, et al. Cobalamin deficiency in the elderly: Aetiology and management: A study of 125 patients in a geriatric hospital. J Nutr Health Aging. 2015;19(2):234-9. DOI:10.1007/s12603-014-0525-1
55. Yang W, Cai X, Wu H, Ji L. Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: A meta-analysis. J Diabetes. 2019;11(9):729-43. DOI:10.1111/1753-0407.12900
56. Spence JD. Metabolic vitamin B12 deficiency: A missed opportunity to prevent dementia and stroke. Nutr Res. 2016;36(2):109-16. DOI:10.1016/j.nutres.2015.10.003
57. Wong CW. Vitamin B12 deficiency in the elderly: Is it worth screening? Hong Kong Med J. 2015;21(2):155-64. DOI:10.12809/hkmj144383
58. Резолюция совета экспертов «Недостаточность/дефицит витамина В12 в клинической практике». Профилактическая медицина. 2023;26(1):109-13 [Resolution of the Advisory Board "Deficiency/Deficit of vitamin B12 in clinical practice". Russian Journal of Preventive Medicine. 2023;26(1):109-13 (in Russian)]. DOI:10.17116/profmed202326011109
________________________________________________
2. Park GN, Kim JO, Oh JW, Lee S. Association between anemia and depression: The 2014, 2016, and 2018 Korea National Health and Nutrition Examination Survey. J Affect Disord. 2022;312:86-91. DOI:10.1016/j.jad.2022.06.015
3. Oh J, Lee T, Chung ES et al. Development of depression detection algorithm using text scripts of routine psychiatric interview. Front Psychiatry. 2024;14:1256571. DOI:10.3389/fpsyt.2023.1256571
4. Kim GE, Jo MW, Shin YW. Increased prevalence of depression in South Korea from 2002 to 2013. Sci Rep. 2020;10(1):16979. DOI:10.1038/s41598-020-74119-4
5. Kaegi-Braun N, Mueller M, Schuetz P et al. Evaluation of nutritional support and in-hospital mortality in patients with malnutrition. JAMA Netw Open. 2021;4(1):e2033433. DOI:10.1001/jamanetworkopen.2020.33433
6. Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci. 2019;1450(1):15-31. DOI:10.1111/nyas.14092
7. Michalak SS, Sterna W. Coexistence and clinical implications of anemia and depression in the elderly population. Psychiatr Pol. 2023;57(3):517-28. DOI:10.12740/PP/147079
8. Albert KM, Newhouse PA. Estrogen, stress, and depression: Cognitive and biological interactions. Annu Rev Clin Psychol. 2019;15:399-423. DOI:10.1146/annurev-clinpsy-050718-095557
9. Wang J, Wang C, Li X et al. Association of anemia with cognitive function and dementia among older adults: The role of inflammation. J Alzheimers Dis. 2023;96(1):125-34. DOI:10.3233/JAD-230483
10. Knezevic E, Nenic K, Milanovic V, Knezevic NN. The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells. 2023;12(23):2726. DOI:10.3390/cells12232726
11. Lee YJ, Kim HB. Association between anaemia and adult depression: A systematic review and meta-analysis of observational studies. J Epidemiol Community Health. 2020;74(7):565-72. DOI:10.1136/jech-2020-213842
12. Hidese S, Saito K, Asano S, Kunugi H. Association between iron-deficiency anemia and depression: A web-based Japanese investigation. Psychiatry Clin Neurosci. 2018;72(7):513-21. DOI:10.1111/pcn.12656
13. Lever-van Milligen BA, Vogelzangs N, Smit JH, Penninx BW. Hemoglobin levels in persons with depressive and/or anxiety disorders. J Psychosom Res. 2014;76(4):317-21. DOI:10.1016/j.jpsychores.2014.01.004
14. Kang SY, Kim HB, Sunwoo S. Association between anemia and maternal depression: A systematic review and meta-analysis. J Psychiatr Res. 2020;122:88-96. DOI:10.1016/j.jpsychires.2020.01.001
15. Ahmed T, Lamoureux-Lamarche C, Berbiche D, Vasiliadis HM. The association between anemia and depression in older adults and the role of treating anemia. Brain Behav. 2023;13(5):e2973. DOI:10.1002/brb3.2973
16. Si T, Ma X, Zhu W, Zhou Y. Comment on: Association between anemia and depression: results from NHANES 2005–2018 and Mendelian randomization analyses. Ann Hematol. 2024;103(2):689-91. DOI:10.1007/s00277-023-05496-9
17. Costantini L, Pasquarella C, Odone A et al. Screening for depression in primary care with Patient Health Questionnaire-9 (PHQ-9): A systematic review. J Affect Disord. 2021;279:473-83. DOI:10.1016/j.jad.2020.09.131
18. Bekhbat M, Neigh GN. Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety. Brain Behav Immun. 2018;67:1-12. DOI:10.1016/j.bbi.2017.02.006
19. Morssinkhof MWL, van Wylick DW, Priester-Vink S, et al. Associations between sex hormones, sleep problems and depression: A systematic review. Neurosci Biobehav Rev. 2020;118:669-80. DOI:10.1016/j.neubiorev.2020.08.006
20. Wassef A, Nguyen QD, St-André M. Anaemia and depletion of iron stores as risk factors for postpartum depression: A literature review. J Psychosom Obstet Gynaecol. 2019;40(1):19-28. DOI:10.1080/0167482X.2018.1427725
21. Kunugi H. Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psychiatry Clin Neurosci. 2023;77(8):420-33. DOI:10.1111/pcn.13551
22. Peskovets RD, Shtarik SY, Evsyukov AA. Prevalence of anxiety disorders in general medical network and their relationship with risk factors of cardiovascular diseases. Siberian Medical Review. 2019;(6):73-9 (in Russian). DOI:10.20333/2500136-2019-6-73-79
23. Shimokhina NY, Savchenko AA, Petrova MM. Peculiarities of platelet metabolism in patients with acute coronary syndrome with anxiety-depressive disorders and informativity of enzymes in the forecast of development of cardiovascular complications. Pharmaceuticals (Basel). 2020;13(8):169. DOI:10.3390/ph13080169
24. Ovsyannikov ES, Drobysheva ES, Tokmachev RE. Study of the severity of anxiety and depression in patients with chronic heart failure combined with anemia. Russian Cardiology Bulletin. 2022;17(2-2):87 (in Russian).
25. Lin PY, Li LC, Wang LJ et al. Lack of association between erythropoietin treatment and risk of depression in patients with end-stage kidney disease on maintenance dialysis: A nationwide database study in Taiwan. Ther Adv Chronic Dis. 2021;12:2040622321995690. DOI:10.1177/2040622321995690
26. Liu M, He E, Fu X et al. Cerebral blood flow self-regulation in depression. J Affect Disord. 2022;302:324-31. DOI:10.1016/j.jad.2022.01.057
27. Chiappelli J, Adhikari BM, Kvarta MD et al. Depression, stress and regional cerebral blood flow. J Cereb Blood Flow Metab. 2023;43(5):791-800. DOI:10.1177/0271678X221148979
28. Oh J, Chae JH, Kim TS. Age-specific association between body mass index and depression: The Korea National Health and Nutrition Examination Survey 2014. Int J Obes (Lond). 2018;42(3):327-33. DOI:10.1038/ijo.2017.234
29. Yu B, Zhang X, Wang C et al. Trends in depression among adults in the United States, NHANES 2005–2016. J Affect Disord. 2020;263:609-20. DOI:10.1016/j.jad.2019.11.036
30. Bruserud Ø, Vo AK, Rekvam H. Hematopoiesis, inflammation and aging-the biological background and clinical impact of anemia and increased c-reactive protein levels on elderly individuals. J Clin Med. 2022;11(3):706. DOI:10.3390/jcm11030706
31. Xie J, Van Hoecke L, Vandenbroucke RE. The impact of systemic inflammation on Alzheimer's disease pathology. Front Immunol. 2022;12:796867. DOI:10.3389/fimmu.2021.796867
32. Chen YH, Karimi M, Rutten-van Mölken MPMH. The disease burden of multimorbidity and its interaction with educational level. PLoS One. 2020;15(12):e0243275. DOI:10.1371/journal.pone.0243275
33. Girelli D, Marchi G, Camaschella C. Anemia in the elderly. Hemasphere. 2018;2(3):e40. DOI:10.1097/HS9.0000000000000040
34. Grande G, Marengoni A, Vetrano DL et al. Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. Alzheimers Dement. 2021;17(5):768-76. DOI:10.1002/alz.12237
35. Burtscher J, Mallet RT, Burtscher M, Millet GP. Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Res Rev. 2021;68:101343. DOI:10.1016/j.arr.2021.101343
36. Kung WM, Yuan SP, Lin MS, et al. Anemia and the risk of cognitive impairment: An updated systematic review and meta-analysis. Brain Sci. 2021;11(6):777. DOI:10.3390/brainsci11060777
37. Shobatake R, Ota H, Takahashi N et al. The impact of intermittent hypoxia on metabolism and cognition. Int J Mol Sci. 2022;23(21):12957. DOI:10.3390/ijms232112957
38. Thakur S, Dhapola R, Sarma P et al. Neuroinflammation in Alzheimer's disease: Current progress in molecular signaling and therapeutics. Inflammation. 2023;46(1):1-17. DOI:10.1007/s10753-022-01721-1
39. Wang M, Pan W, Xu Y et al. Microglia-mediated neuroinflammation: A potential target for the treatment of cardiovascular diseases. J Inflamm Res. 2022;15:3083-94. DOI:10.2147/JIR.S350109
40. Fabrício DM, Chagas MHN, Diniz BS. Frailty and cognitive decline. Transl Res. 2020;221:58-64. DOI:10.1016/j.trsl.2020.01.002
41. Guo L, Tian J, Du H. Mitochondrial dysfunction and synaptic transmission failure in Alzheimer's disease. J Alzheimers Dis. 2017;57(4):1071-86. DOI:10.3233/JAD-160702
42. Wang Z, Zhu W, Xing Y et al. B vitamins and prevention of cognitive decline and incident dementia: A systematic review and meta-analysis. Nutr Rev. 2022;80(4):931-49. DOI:10.1093/nutrit/nuab057
43. Teleanu DM, Niculescu AG, Lungu II et al. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int J Mol Sci. 2022;23(11):5938. DOI:10.3390/ijms23115938
44. Lauer AA, Grimm HS, Apel B et al. Mechanistic link between vitamin B12 and Alzheimer's disease. Biomolecules. 2022;12(1):129. DOI:10.3390/biom12010129.4
45. Gao W, Zhu WW, Yu YH, Wang J. Plasma homocysteine level, estradiol level, and brain atrophy: A Mendelian randomization study. Cereb Cortex. 2024;34(3):bhae112. DOI:10.1093/cercor/bhae112
46. Qiang YX, Deng YT, Zhang YR et al. Associations of blood cell indices and anemia with risk of incident dementia: A prospective cohort study of 313,448 participants. Alzheimers Dement. 2023;19(9):3965-76. DOI:10.1002/alz.13088
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Авторы
М.М. Петрова*, Н.Ю. Шимохина, А.А. Суворова
ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск, Российская Федерация
*stk99@yandex.ru
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
*stk99@yandex.ru
ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск, Российская Федерация
*stk99@yandex.ru
________________________________________________
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
*stk99@yandex.ru
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